MTO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)6.33430486
2behavioral response to nicotine (GO:0035095)5.66096967
3folic acid-containing compound biosynthetic process (GO:0009396)5.47832435
4cysteine metabolic process (GO:0006534)5.34579786
5primary amino compound metabolic process (GO:1901160)5.12488029
6indole-containing compound catabolic process (GO:0042436)4.95516768
7indolalkylamine catabolic process (GO:0046218)4.95516768
8tryptophan catabolic process (GO:0006569)4.95516768
9sulfur amino acid catabolic process (GO:0000098)4.87768885
10microtubule nucleation (GO:0007020)4.84039623
11kynurenine metabolic process (GO:0070189)4.82173676
12white fat cell differentiation (GO:0050872)4.54593881
13tRNA methylation (GO:0030488)4.49068317
14regulation of plasminogen activation (GO:0010755)4.47752921
15DNA deamination (GO:0045006)4.29873931
16tryptophan metabolic process (GO:0006568)4.29079395
17indolalkylamine metabolic process (GO:0006586)4.25599886
18epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.21428543
19indole-containing compound metabolic process (GO:0042430)3.78591320
20protein-cofactor linkage (GO:0018065)3.78512693
21negative regulation of DNA biosynthetic process (GO:2000279)3.71141569
22organic cation transport (GO:0015695)3.70916858
23regulation of sequestering of triglyceride (GO:0010889)3.69046223
24inner ear receptor cell development (GO:0060119)3.61333257
25superoxide anion generation (GO:0042554)3.56026961
26fucose catabolic process (GO:0019317)3.55149618
27L-fucose metabolic process (GO:0042354)3.55149618
28L-fucose catabolic process (GO:0042355)3.55149618
29sulfur amino acid biosynthetic process (GO:0000097)3.54542538
30phosphatidylglycerol biosynthetic process (GO:0006655)3.46843778
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.46687955
32pteridine-containing compound biosynthetic process (GO:0042559)3.43348628
33meiotic chromosome segregation (GO:0045132)3.42142785
34cilium or flagellum-dependent cell motility (GO:0001539)3.37584662
35positive regulation of oligodendrocyte differentiation (GO:0048714)3.36172979
36telomere maintenance via semi-conservative replication (GO:0032201)3.35064872
37alternative mRNA splicing, via spliceosome (GO:0000380)3.29995860
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.28542087
39purine nucleotide salvage (GO:0032261)3.28527605
40positive regulation of fatty acid oxidation (GO:0046321)3.28092818
41* tRNA modification (GO:0006400)3.27540160
42histone H4-K12 acetylation (GO:0043983)3.23162430
43DNA integration (GO:0015074)3.19067425
44negative regulation of keratinocyte proliferation (GO:0010839)3.18500507
45pseudouridine synthesis (GO:0001522)3.18414157
46acrosome assembly (GO:0001675)3.17627013
47nucleotide transmembrane transport (GO:1901679)3.16901731
48CENP-A containing nucleosome assembly (GO:0034080)3.15626121
49cochlea development (GO:0090102)3.11124045
50protein-chromophore linkage (GO:0018298)3.11051409
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.10450417
52sulfation (GO:0051923)3.09053153
53tetrahydrofolate metabolic process (GO:0046653)3.06071392
54DNA synthesis involved in DNA repair (GO:0000731)3.06064652
55detection of light stimulus involved in visual perception (GO:0050908)3.05539535
56detection of light stimulus involved in sensory perception (GO:0050962)3.05539535
57telomere maintenance via recombination (GO:0000722)3.05517645
58cellular ketone body metabolic process (GO:0046950)3.05055521
59behavioral defense response (GO:0002209)3.05007045
60behavioral fear response (GO:0001662)3.05007045
61positive regulation of endothelial cell differentiation (GO:0045603)3.04709398
62RNA methylation (GO:0001510)3.01725203
63kinetochore assembly (GO:0051382)2.99515686
64negative regulation of interleukin-1 beta production (GO:0032691)2.99328223
65DNA replication initiation (GO:0006270)2.97774864
66chromatin remodeling at centromere (GO:0031055)2.97586645
67rRNA methylation (GO:0031167)2.97028551
68mismatch repair (GO:0006298)2.95657958
69amino acid salvage (GO:0043102)2.95555316
70L-methionine salvage (GO:0071267)2.95555316
71L-methionine biosynthetic process (GO:0071265)2.95555316
72negative regulation of mast cell activation (GO:0033004)2.95445345
73adaptation of signaling pathway (GO:0023058)2.93829193
74respiratory chain complex IV assembly (GO:0008535)2.93001467
75DNA strand renaturation (GO:0000733)2.92868071
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92214422
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92214422
78kinetochore organization (GO:0051383)2.90469079
79* tRNA processing (GO:0008033)2.89199683
80adult feeding behavior (GO:0008343)2.88752180
81rRNA modification (GO:0000154)2.83919195
82folic acid-containing compound metabolic process (GO:0006760)2.83696001
83serine family amino acid catabolic process (GO:0009071)2.82678055
84NAD biosynthetic process (GO:0009435)2.82180672
85deoxyribonucleotide biosynthetic process (GO:0009263)2.81808203
86cellular biogenic amine catabolic process (GO:0042402)2.81803017
87amine catabolic process (GO:0009310)2.81803017
88preassembly of GPI anchor in ER membrane (GO:0016254)2.81635968
89protein K6-linked ubiquitination (GO:0085020)2.81529025
90microtubule depolymerization (GO:0007019)2.80293361
91telomere maintenance via telomere lengthening (GO:0010833)2.79726261
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79096475
93quinone biosynthetic process (GO:1901663)2.78903502
94ubiquinone biosynthetic process (GO:0006744)2.78903502
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78529934
96isotype switching (GO:0045190)2.78529934
97somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78529934
98cartilage morphogenesis (GO:0060536)2.78477940
99methionine biosynthetic process (GO:0009086)2.77438992
100centriole assembly (GO:0098534)2.77263997
101S-adenosylmethionine metabolic process (GO:0046500)2.76751345
102aromatic amino acid family catabolic process (GO:0009074)2.76570161
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76415382
104replicative senescence (GO:0090399)2.75538487
105mitotic recombination (GO:0006312)2.74983086
106polyketide metabolic process (GO:0030638)2.74375485
107doxorubicin metabolic process (GO:0044598)2.74375485
108daunorubicin metabolic process (GO:0044597)2.74375485
109regulation of gonadotropin secretion (GO:0032276)2.74278245
110DNA catabolic process, exonucleolytic (GO:0000738)2.74095222
111DNA strand elongation (GO:0022616)2.73534934
112sulfur amino acid metabolic process (GO:0000096)2.72943534
113regulation of mitochondrial translation (GO:0070129)2.72739798
114regulation of endothelial cell differentiation (GO:0045601)2.72648337
115negative regulation of telomere maintenance (GO:0032205)2.72623032
116negative regulation of Ras GTPase activity (GO:0034261)2.70296673
117benzene-containing compound metabolic process (GO:0042537)2.69472984
118gamma-aminobutyric acid signaling pathway (GO:0007214)2.69285791
119DNA strand elongation involved in DNA replication (GO:0006271)2.67909777
120gamma-aminobutyric acid transport (GO:0015812)2.67816489
121regulation of vitamin D biosynthetic process (GO:0060556)2.67548768
122GPI anchor biosynthetic process (GO:0006506)2.67474646
123fear response (GO:0042596)2.67123558
124one-carbon metabolic process (GO:0006730)2.67059844
125cytochrome complex assembly (GO:0017004)2.67055002
126ketone body metabolic process (GO:1902224)2.66887905
127positive regulation of protein homodimerization activity (GO:0090073)2.65691274
128negative regulation of granulocyte differentiation (GO:0030853)2.65186822
129negative regulation of transcription by competitive promoter binding (GO:0010944)2.64872542
130negative regulation of interleukin-1 production (GO:0032692)2.64522541
131protein heterotetramerization (GO:0051290)2.63849357
132heme transport (GO:0015886)2.63343123
133ubiquinone metabolic process (GO:0006743)2.62005556
134nucleoside transmembrane transport (GO:1901642)2.61956675
135deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.61715430
136regulation of sarcomere organization (GO:0060297)2.61124736
137L-serine metabolic process (GO:0006563)2.58838983
138viral mRNA export from host cell nucleus (GO:0046784)2.57708012
139DNA ligation (GO:0006266)2.57630301
140protein K11-linked deubiquitination (GO:0035871)2.57502610
141mitochondrial respiratory chain complex assembly (GO:0033108)2.56059973
142DNA methylation involved in gamete generation (GO:0043046)2.54770107
143response to caffeine (GO:0031000)2.54397507
144reciprocal DNA recombination (GO:0035825)2.53375334
145reciprocal meiotic recombination (GO:0007131)2.53375334
146cellular response to interferon-beta (GO:0035458)2.52880552
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.52636762
148serotonin metabolic process (GO:0042428)2.52588389
149positive regulation of T cell mediated cytotoxicity (GO:0001916)2.51403364
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.49379317
151NADH dehydrogenase complex assembly (GO:0010257)2.49379317
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49379317
153regulation of DNA endoreduplication (GO:0032875)2.48387063
154neutrophil mediated immunity (GO:0002446)2.48314860
155hepatocyte differentiation (GO:0070365)2.48309028
156platelet dense granule organization (GO:0060155)2.48072056
157mannosylation (GO:0097502)2.47382166
158energy homeostasis (GO:0097009)2.46722363
159natural killer cell activation involved in immune response (GO:0002323)2.45868677
160* tRNA metabolic process (GO:0006399)2.45867626
161androgen biosynthetic process (GO:0006702)2.43135871
162DNA demethylation (GO:0080111)2.42636225
163telomere maintenance (GO:0000723)2.39428697
164antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.39154629
165telomere organization (GO:0032200)2.39106378
166B cell activation involved in immune response (GO:0002312)2.38881397
167proteasome assembly (GO:0043248)2.38384312
168synapsis (GO:0007129)2.38286685
169response to folic acid (GO:0051593)2.37841780
170G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.37430322
171detection of other organism (GO:0098543)2.37094036
172intra-S DNA damage checkpoint (GO:0031573)2.36820191
173lymphoid progenitor cell differentiation (GO:0002320)2.36812230
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.36285935
175termination of RNA polymerase III transcription (GO:0006386)2.36285935
176protein complex biogenesis (GO:0070271)2.35305532
177phospholipid scrambling (GO:0017121)2.35221738
178endosome to melanosome transport (GO:0035646)2.35077122
179endosome to pigment granule transport (GO:0043485)2.35077122
180GPI anchor metabolic process (GO:0006505)2.34080051
181negative regulation of execution phase of apoptosis (GO:1900118)2.32821421
182regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32593844
183* RNA modification (GO:0009451)2.31079568
184* adenosine metabolic process (GO:0046085)2.29408329
185DNA replication-independent nucleosome organization (GO:0034724)2.28792210
186DNA replication-independent nucleosome assembly (GO:0006336)2.28792210
187exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.26057747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.05284700
2VDR_22108803_ChIP-Seq_LS180_Human3.87152022
3ZNF274_21170338_ChIP-Seq_K562_Hela3.76709497
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.14860056
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10972121
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.02364232
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.73262227
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66835390
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59380578
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53522156
11EZH2_22144423_ChIP-Seq_EOC_Human2.51031463
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.50857310
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36565376
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32257689
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.29685089
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.28113691
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26916219
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20202684
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.18447583
20FUS_26573619_Chip-Seq_HEK293_Human2.14584606
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.13630245
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.08695965
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07646799
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07171153
25SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03347676
26ER_23166858_ChIP-Seq_MCF-7_Human2.01610609
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00853801
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99351889
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98742416
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.94565512
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.89541234
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87777360
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.87384692
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87191365
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84800546
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82809274
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.82427301
38P300_19829295_ChIP-Seq_ESCs_Human1.81349202
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80511711
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79850944
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79087284
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78927462
43TP53_22573176_ChIP-Seq_HFKS_Human1.78766627
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77607940
45GBX2_23144817_ChIP-Seq_PC3_Human1.75929493
46STAT3_23295773_ChIP-Seq_U87_Human1.75708262
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75593294
48IGF1R_20145208_ChIP-Seq_DFB_Human1.74489667
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73145660
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68534616
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68116754
52BCAT_22108803_ChIP-Seq_LS180_Human1.67483934
53IRF1_19129219_ChIP-ChIP_H3396_Human1.64118457
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62444203
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62219373
56SCL_19346495_ChIP-Seq_HPC-7_Human1.61721901
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60659518
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57995572
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57856921
60VDR_23849224_ChIP-Seq_CD4+_Human1.56415465
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54546801
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.54201541
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.49896992
64CDX2_22108803_ChIP-Seq_LS180_Human1.49678060
65* MYC_18555785_ChIP-Seq_MESCs_Mouse1.48702047
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48300074
67NMYC_18555785_Chip-Seq_ESCs_Mouse1.47891645
68* FOXP3_21729870_ChIP-Seq_TREG_Human1.45864935
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45226005
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44694399
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43512046
72NCOR_22424771_ChIP-Seq_293T_Human1.43021505
73CBP_20019798_ChIP-Seq_JUKART_Human1.42900270
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42900270
75RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42511192
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.41666386
77TCF4_23295773_ChIP-Seq_U87_Human1.41400868
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38858862
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37001827
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35131147
81P53_22387025_ChIP-Seq_ESCs_Mouse1.35056427
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.34768757
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.33863746
84ZFX_18555785_Chip-Seq_ESCs_Mouse1.32957630
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32457522
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32333392
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31569784
88RUNX2_22187159_ChIP-Seq_PCA_Human1.31421418
89P300_18555785_Chip-Seq_ESCs_Mouse1.31297285
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.31120605
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31120605
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31071393
93* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30822580
94MYC_18940864_ChIP-ChIP_HL60_Human1.30731279
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30427308
96* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30193654
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.30184136
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30097685
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30090221
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29585307
101AR_25329375_ChIP-Seq_VCAP_Human1.27403923
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.26672271
103PU1_27457419_Chip-Seq_LIVER_Mouse1.26457472
104TCF4_22108803_ChIP-Seq_LS180_Human1.25920557
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25732004
106SOX2_19829295_ChIP-Seq_ESCs_Human1.25526563
107NANOG_19829295_ChIP-Seq_ESCs_Human1.25526563
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25429331
109SMAD4_21799915_ChIP-Seq_A2780_Human1.25148963
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.24921754
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24340355
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.24243915
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24007777
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.23974050
115ETS1_20019798_ChIP-Seq_JURKAT_Human1.22713643
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.22453241
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.22445466
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22249903
119SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21591951
120ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21515000
121HOXB7_26014856_ChIP-Seq_BT474_Human1.21400723
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20090826
123OCT1_27270436_Chip-Seq_PROSTATE_Human1.19531371
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18592302
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18578656
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18420120
127* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17694876
128KAP1_22055183_ChIP-Seq_ESCs_Mouse1.17114411
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17041308
130E2F1_21310950_ChIP-Seq_MCF-7_Human1.16946062
131TAF15_26573619_Chip-Seq_HEK293_Human1.16833600
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16534685
133SOX2_18555785_Chip-Seq_ESCs_Mouse1.16331986
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16312205
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.15009994
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.14379641
137DCP1A_22483619_ChIP-Seq_HELA_Human1.13284882
138GATA3_21878914_ChIP-Seq_MCF-7_Human1.13167140
139ELK1_19687146_ChIP-ChIP_HELA_Human1.12930730
140TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12451167
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11997695
142EWS_26573619_Chip-Seq_HEK293_Human1.11128093
143CTCF_18555785_Chip-Seq_ESCs_Mouse1.10964489
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10810047
145* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09485768
146CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09266802
147BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08709090
148AR_20517297_ChIP-Seq_VCAP_Human1.08299445
149TP53_16413492_ChIP-PET_HCT116_Human1.07212277
150REST_21632747_ChIP-Seq_MESCs_Mouse1.06811093
151CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06507088
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06333787
153* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05838099
154PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04917694
155TAL1_26923725_Chip-Seq_HPCs_Mouse1.04676093
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04410809
157ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03716842
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03565387
159GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03445665
160GATA3_26560356_Chip-Seq_TH2_Human1.03376234
161TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01336556
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01196899
163KDM2B_26808549_Chip-Seq_REH_Human1.00001071
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.98870311
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.98518407
166TAF2_19829295_ChIP-Seq_ESCs_Human0.96372648
167PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95845265
168GATA3_26560356_Chip-Seq_TH1_Human0.95605216
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95306806
170OCT4_20526341_ChIP-Seq_ESCs_Human0.94857103
171FOXH1_21741376_ChIP-Seq_ESCs_Human0.94849627
172AR_21572438_ChIP-Seq_LNCaP_Human0.94583096
173DROSHA_22980978_ChIP-Seq_HELA_Human0.94043111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.60720155
2MP0008058_abnormal_DNA_repair3.60454512
3MP0006292_abnormal_olfactory_placode3.37054503
4MP0008057_abnormal_DNA_replication3.16667746
5MP0001188_hyperpigmentation3.01222055
6MP0002396_abnormal_hematopoietic_system2.99291923
7MP0004147_increased_porphyrin_level2.71648179
8MP0002102_abnormal_ear_morphology2.61283531
9MP0002736_abnormal_nociception_after2.59811785
10MP0001835_abnormal_antigen_presentation2.59141369
11MP0005075_abnormal_melanosome_morpholog2.50588753
12MP0004043_abnormal_pH_regulation2.49539328
13MP0004885_abnormal_endolymph2.46586794
14MP0010094_abnormal_chromosome_stability2.41347725
15MP0009697_abnormal_copulation2.36575790
16MP0001968_abnormal_touch/_nociception2.34604581
17MP0002132_abnormal_respiratory_system2.31711481
18MP0000015_abnormal_ear_pigmentation2.31138203
19MP0008872_abnormal_physiological_respon2.26912829
20MP0004381_abnormal_hair_follicle2.22926622
21MP0003195_calcinosis2.21319150
22MP0002938_white_spotting2.21221728
23MP0008260_abnormal_autophagy2.16612590
24MP0004130_abnormal_muscle_cell2.14737329
25MP0003183_abnormal_peptide_metabolism2.09822390
26MP0003693_abnormal_embryo_hatching2.06691241
27MP0002138_abnormal_hepatobiliary_system2.03598334
28MP0001661_extended_life_span2.00385144
29MP0003111_abnormal_nucleus_morphology1.96900579
30MP0003724_increased_susceptibility_to1.94356078
31MP0005671_abnormal_response_to1.92257880
32MP0009785_altered_susceptibility_to1.90528180
33MP0000013_abnormal_adipose_tissue1.88953693
34MP0005174_abnormal_tail_pigmentation1.82743623
35MP0005379_endocrine/exocrine_gland_phen1.81083280
36MP0000566_synostosis1.79474207
37MP0002277_abnormal_respiratory_mucosa1.75948757
38MP0002148_abnormal_hypersensitivity_rea1.75525600
39MP0003136_yellow_coat_color1.73660273
40MP0005451_abnormal_body_composition1.73386499
41MP0005409_darkened_coat_color1.69904323
42MP0005332_abnormal_amino_acid1.65879244
43MP0003786_premature_aging1.63592321
44MP0005253_abnormal_eye_physiology1.63551646
45MP0002638_abnormal_pupillary_reflex1.61573556
46MP0005646_abnormal_pituitary_gland1.60268625
47MP0002419_abnormal_innate_immunity1.58068938
48MP0002095_abnormal_skin_pigmentation1.57719573
49MP0005025_abnormal_response_to1.56439838
50MP0005085_abnormal_gallbladder_physiolo1.55151207
51MP0008007_abnormal_cellular_replicative1.54017571
52MP0002735_abnormal_chemical_nociception1.53641356
53MP0008875_abnormal_xenobiotic_pharmacok1.52920599
54MP0003646_muscle_fatigue1.52919599
55MP0002160_abnormal_reproductive_system1.52774696
56MP0000490_abnormal_crypts_of1.49100963
57MP0002837_dystrophic_cardiac_calcinosis1.48791426
58MP0002876_abnormal_thyroid_physiology1.46140776
59MP0000631_abnormal_neuroendocrine_gland1.45205797
60MP0003077_abnormal_cell_cycle1.40259071
61MP0001764_abnormal_homeostasis1.39239941
62MP0003252_abnormal_bile_duct1.38802909
63MP0009745_abnormal_behavioral_response1.36915540
64MP0005387_immune_system_phenotype1.36112385
65MP0001790_abnormal_immune_system1.36112385
66MP0001853_heart_inflammation1.34998113
67MP0005367_renal/urinary_system_phenotyp1.34948736
68MP0000516_abnormal_urinary_system1.34948736
69MP0001984_abnormal_olfaction1.31413618
70MP0002723_abnormal_immune_serum1.31359230
71MP0006072_abnormal_retinal_apoptosis1.31231237
72MP0000372_irregular_coat_pigmentation1.31113372
73MP0005389_reproductive_system_phenotype1.30143685
74MP0001986_abnormal_taste_sensitivity1.30035512
75MP0001800_abnormal_humoral_immune1.28506834
76MP0002452_abnormal_antigen_presenting1.28143100
77MP0001485_abnormal_pinna_reflex1.25161121
78MP0000465_gastrointestinal_hemorrhage1.23370762
79MP0001819_abnormal_immune_cell1.22999689
80MP0002420_abnormal_adaptive_immunity1.22415363
81MP0003763_abnormal_thymus_physiology1.22029830
82MP0004133_heterotaxia1.21250310
83MP0000427_abnormal_hair_cycle1.21026639
84MP0001919_abnormal_reproductive_system1.20996061
85MP0009046_muscle_twitch1.20813957
86MP0000647_abnormal_sebaceous_gland1.18265432
87MP0001486_abnormal_startle_reflex1.17956480
88MP0003186_abnormal_redox_activity1.16915897
89MP0001501_abnormal_sleep_pattern1.15395681
90MP0002398_abnormal_bone_marrow1.13334192
91MP0001186_pigmentation_phenotype1.13304881
92MP0005000_abnormal_immune_tolerance1.12883424
93MP0000716_abnormal_immune_system1.09737132
94MP0003045_fibrosis1.09475826
95MP0000689_abnormal_spleen_morphology1.09430295
96MP0005410_abnormal_fertilization1.03749343
97MP0009764_decreased_sensitivity_to1.03274580
98MP0005670_abnormal_white_adipose1.02428263
99MP0008877_abnormal_DNA_methylation1.00110288
100MP0002075_abnormal_coat/hair_pigmentati0.99043731
101MP0009333_abnormal_splenocyte_physiolog0.97876503
102MP0004742_abnormal_vestibular_system0.97716138
103MP0002429_abnormal_blood_cell0.97473691
104MP0003806_abnormal_nucleotide_metabolis0.96573388
105MP0006036_abnormal_mitochondrial_physio0.94723532
106MP0008995_early_reproductive_senescence0.93653278
107MP0002722_abnormal_immune_system0.93466894
108MP0005171_absent_coat_pigmentation0.93342575
109MP0004782_abnormal_surfactant_physiolog0.93039820
110MP0003172_abnormal_lysosome_physiology0.90582449
111MP0002272_abnormal_nervous_system0.89069606
112MP0002009_preneoplasia0.88875803
113MP0000685_abnormal_immune_system0.87570148
114MP0000538_abnormal_urinary_bladder0.86721970
115MP0001119_abnormal_female_reproductive0.84720325
116MP0001756_abnormal_urination0.83479959
117MP0002928_abnormal_bile_duct0.83217652
118MP0000230_abnormal_systemic_arterial0.82349546
119MP0003698_abnormal_male_reproductive0.82137779
120MP0006082_CNS_inflammation0.81454090
121MP0001502_abnormal_circadian_rhythm0.81402564
122MP0005464_abnormal_platelet_physiology0.80993383
123MP0004142_abnormal_muscle_tone0.80242267
124MP0003890_abnormal_embryonic-extraembry0.80024138
125MP0009643_abnormal_urine_homeostasis0.79956480
126MP0005551_abnormal_eye_electrophysiolog0.79469690
127MP0004808_abnormal_hematopoietic_stem0.79018092
128MP0005645_abnormal_hypothalamus_physiol0.78883133
129MP0000569_abnormal_digit_pigmentation0.77971906
130MP0003718_maternal_effect0.77589015
131MP0005647_abnormal_sex_gland0.77178690
132MP0008469_abnormal_protein_level0.77075732
133MP0000383_abnormal_hair_follicle0.76782772
134MP0004019_abnormal_vitamin_homeostasis0.76693641
135MP0005195_abnormal_posterior_eye0.76036317
136MP0004145_abnormal_muscle_electrophysio0.75974930
137MP0001905_abnormal_dopamine_level0.75238922
138MP0003436_decreased_susceptibility_to0.74920140
139MP0005167_abnormal_blood-brain_barrier0.74448922
140MP0001529_abnormal_vocalization0.74255548
141MP0000653_abnormal_sex_gland0.73730090
142MP0000703_abnormal_thymus_morphology0.73598671
143MP0002405_respiratory_system_inflammati0.73478789
144MP0006276_abnormal_autonomic_nervous0.73446189
145MP0002229_neurodegeneration0.73161388
146MP0001944_abnormal_pancreas_morphology0.72968827
147MP0003828_pulmonary_edema0.72834781
148MP0001545_abnormal_hematopoietic_system0.72456056
149MP0005397_hematopoietic_system_phenotyp0.72456056
150MP0002693_abnormal_pancreas_physiology0.71226075
151MP0002210_abnormal_sex_determination0.70792817
152MP0001845_abnormal_inflammatory_respons0.70513720
153MP0002163_abnormal_gland_morphology0.70384327
154MP0005386_behavior/neurological_phenoty0.70165864
155MP0004924_abnormal_behavior0.70165864
156MP0001324_abnormal_eye_pigmentation0.69933386
157MP0008775_abnormal_heart_ventricle0.69775096
158MP0002572_abnormal_emotion/affect_behav0.69632995
159MP0002064_seizures0.68749152
160MP0001929_abnormal_gametogenesis0.68748577
161MP0002933_joint_inflammation0.68337271
162MP0000371_diluted_coat_color0.67319099
163MP0000026_abnormal_inner_ear0.66779795
164MP0001963_abnormal_hearing_physiology0.63278480

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.77052345
2Chromsome breakage (HP:0040012)6.40375219
3Congenital sensorineural hearing impairment (HP:0008527)5.19178197
4Constricted visual fields (HP:0001133)4.97486322
5Duplicated collecting system (HP:0000081)4.90070564
6Abnormality of the renal collecting system (HP:0004742)4.62155201
7Decreased electroretinogram (ERG) amplitude (HP:0000654)4.38385967
8Abnormality of DNA repair (HP:0003254)4.37643309
9Pancreatic cysts (HP:0001737)3.79665455
10Renal cortical cysts (HP:0000803)3.76447055
11Reticulocytopenia (HP:0001896)3.55609671
12Abnormality of the preputium (HP:0100587)3.51492752
13Chorioretinal atrophy (HP:0000533)3.50253165
14Abnormality of homocysteine metabolism (HP:0010919)3.45530457
15Homocystinuria (HP:0002156)3.45530457
16Abnormality of midbrain morphology (HP:0002418)3.30736862
17Molar tooth sign on MRI (HP:0002419)3.30736862
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.30329102
19Meckel diverticulum (HP:0002245)3.28983812
20Abnormality of the ileum (HP:0001549)3.24193999
21Pendular nystagmus (HP:0012043)3.23545378
22Abolished electroretinogram (ERG) (HP:0000550)3.15704371
23Progressive cerebellar ataxia (HP:0002073)3.15448708
24Abnormality of chromosome stability (HP:0003220)3.11416741
25Birth length less than 3rd percentile (HP:0003561)3.05635321
26Ectopic kidney (HP:0000086)3.05470182
27Clubbing of toes (HP:0100760)3.03868646
28Spontaneous hematomas (HP:0007420)2.93132245
29Upper limb muscle weakness (HP:0003484)2.89412015
30Abnormality of pyrimidine metabolism (HP:0004353)2.87760111
31Microvesicular hepatic steatosis (HP:0001414)2.80887110
32Genetic anticipation (HP:0003743)2.77415824
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.70007197
34Anorexia (HP:0002039)2.67546260
35Type I transferrin isoform profile (HP:0003642)2.65060489
36Reduced antithrombin III activity (HP:0001976)2.65059835
37Increased corneal curvature (HP:0100692)2.57170377
38Keratoconus (HP:0000563)2.57170377
39Pigmentary retinal degeneration (HP:0001146)2.57073502
40Pancytopenia (HP:0001876)2.56023137
41* Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52067709
42* Abnormality of alanine metabolism (HP:0010916)2.52067709
43* Hyperalaninemia (HP:0003348)2.52067709
44Bone marrow hypocellularity (HP:0005528)2.51675677
45Aplastic anemia (HP:0001915)2.46671782
46Gaze-evoked nystagmus (HP:0000640)2.46632452
47Nephronophthisis (HP:0000090)2.45480904
48Increased hepatocellular lipid droplets (HP:0006565)2.41281408
49Conjugated hyperbilirubinemia (HP:0002908)2.40344756
50Hypergonadotropic hypogonadism (HP:0000815)2.38123087
51Inability to walk (HP:0002540)2.33960686
52Esophageal varix (HP:0002040)2.30972605
53Abnormality of the renal cortex (HP:0011035)2.30273935
54Congenital stationary night blindness (HP:0007642)2.28399525
55Abnormality of the prostate (HP:0008775)2.28016078
56True hermaphroditism (HP:0010459)2.27540193
57Decreased circulating renin level (HP:0003351)2.26901076
58Hyperventilation (HP:0002883)2.26684607
59Cystic liver disease (HP:0006706)2.24024605
60Patchy hypopigmentation of hair (HP:0011365)2.23337923
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.23306464
62Abnormality of the renal medulla (HP:0100957)2.22029876
63Prolonged partial thromboplastin time (HP:0003645)2.21086633
64Lipid accumulation in hepatocytes (HP:0006561)2.19288499
653-Methylglutaconic aciduria (HP:0003535)2.19266980
66Septo-optic dysplasia (HP:0100842)2.18823363
67Small hand (HP:0200055)2.17833294
68Absent thumb (HP:0009777)2.17706227
69Duplication of thumb phalanx (HP:0009942)2.16959485
70Anencephaly (HP:0002323)2.16375567
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.16362422
72Dyskinesia (HP:0100660)2.13047725
73Action tremor (HP:0002345)2.11979461
74Exertional dyspnea (HP:0002875)2.11316781
75Chronic otitis media (HP:0000389)2.09701709
76Recurrent abscess formation (HP:0002722)2.09655877
77Duodenal stenosis (HP:0100867)2.08527901
78Small intestinal stenosis (HP:0012848)2.08527901
79Tubular atrophy (HP:0000092)2.07447885
80Myelodysplasia (HP:0002863)2.06821299
81Aplasia/Hypoplasia of the patella (HP:0006498)2.06419174
82Clumsiness (HP:0002312)2.06200290
83Patellar aplasia (HP:0006443)2.05680628
84Prostate neoplasm (HP:0100787)2.05045914
85Abnormality of the carotid arteries (HP:0005344)2.04876803
86Polydipsia (HP:0001959)2.04745494
87Abnormal drinking behavior (HP:0030082)2.04745494
88Prolonged bleeding time (HP:0003010)2.02298016
89Progressive inability to walk (HP:0002505)2.00300383
90Renal Fanconi syndrome (HP:0001994)1.99639900
91Abnormal rod and cone electroretinograms (HP:0008323)1.98962903
92Retrobulbar optic neuritis (HP:0100654)1.98737936
93Optic neuritis (HP:0100653)1.98737936
94* Increased serum lactate (HP:0002151)1.98086111
95Ketoacidosis (HP:0001993)1.98021269
96Medial flaring of the eyebrow (HP:0010747)1.97613309
97Decreased central vision (HP:0007663)1.97222606
98Fair hair (HP:0002286)1.96338505
99Pulmonary embolism (HP:0002204)1.95317808
100Mitochondrial inheritance (HP:0001427)1.92694923
101Generalized aminoaciduria (HP:0002909)1.92480984
102Increased CSF lactate (HP:0002490)1.92317191
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92199109
104Furrowed tongue (HP:0000221)1.91895592
105Abnormal biliary tract physiology (HP:0012439)1.91659684
106Bile duct proliferation (HP:0001408)1.91659684
107Type 2 muscle fiber atrophy (HP:0003554)1.91166882
108Hyperglycinemia (HP:0002154)1.89454730
109Ureteral duplication (HP:0000073)1.89391487
110Protruding tongue (HP:0010808)1.89161848
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88702697
112Abnormal protein N-linked glycosylation (HP:0012347)1.88702697
113Abnormal protein glycosylation (HP:0012346)1.88702697
114Abnormal glycosylation (HP:0012345)1.88702697
115Joint hemorrhage (HP:0005261)1.88592585
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88126475
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87382336
118Type II diabetes mellitus (HP:0005978)1.86563498
119Hepatocellular necrosis (HP:0001404)1.86107625
120Prolonged neonatal jaundice (HP:0006579)1.85580536
121Chronic obstructive pulmonary disease (HP:0006510)1.85246530
122Obstructive lung disease (HP:0006536)1.85246530
123Opisthotonus (HP:0002179)1.84084688
124Decreased subcutaneous fat (HP:0001002)1.83913585
125Large for gestational age (HP:0001520)1.82877094
126Hepatic necrosis (HP:0002605)1.82508047
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82063298
128Elevated erythrocyte sedimentation rate (HP:0003565)1.81178522
129Bony spicule pigmentary retinopathy (HP:0007737)1.80919434
130Ileus (HP:0002595)1.80212965
131Congenital, generalized hypertrichosis (HP:0004540)1.80015792
132Conjunctival telangiectasia (HP:0000524)1.79634255
133Triphalangeal thumb (HP:0001199)1.79302963
134Petechiae (HP:0000967)1.79044535
135Methylmalonic acidemia (HP:0002912)1.78932517
136Short tibia (HP:0005736)1.78928416
137Attenuation of retinal blood vessels (HP:0007843)1.78118371
138Abnormality of the fetal cardiovascular system (HP:0010948)1.78094664
139Abnormal umbilical cord blood vessels (HP:0011403)1.78094664
140Single umbilical artery (HP:0001195)1.78094664
141Abnormal respiratory epithelium morphology (HP:0012253)1.77241021
142Abnormal respiratory motile cilium morphology (HP:0005938)1.77241021
143Tubulointerstitial nephritis (HP:0001970)1.76350426
144Hypothermia (HP:0002045)1.76263286
145Type II lissencephaly (HP:0007260)1.76121318
146Acute necrotizing encephalopathy (HP:0006965)1.75689164
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74334420
148Oligohydramnios (HP:0001562)1.74229088
149Lissencephaly (HP:0001339)1.73483294
150Neutropenia (HP:0001875)1.73471330
151Encephalitis (HP:0002383)1.72906980
152Nephroblastoma (Wilms tumor) (HP:0002667)1.72273599
153Stomach cancer (HP:0012126)1.71060283
154Ketosis (HP:0001946)1.70710063
155Horseshoe kidney (HP:0000085)1.70459150
156Sclerocornea (HP:0000647)1.70111549
157Male pseudohermaphroditism (HP:0000037)1.68607481
158Nephrogenic diabetes insipidus (HP:0009806)1.68322723
159Chronic diarrhea (HP:0002028)1.67480438
160White forelock (HP:0002211)1.67357867
161Recurrent pneumonia (HP:0006532)1.67026532
162Epidermoid cyst (HP:0200040)1.66979093
163Toxemia of pregnancy (HP:0100603)1.66897158
164Chronic hepatic failure (HP:0100626)1.66735324
165Supernumerary spleens (HP:0009799)1.66008502
166Short thumb (HP:0009778)1.65331820
167Pallor (HP:0000980)1.64706089
168Anhidrosis (HP:0000970)1.63940033
169Sloping forehead (HP:0000340)1.63678451
170Dry hair (HP:0011359)1.63135620
171Respiratory difficulties (HP:0002880)1.63104824
172Abnormal mitochondria in muscle tissue (HP:0008316)1.62988274
173Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62977404
174Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62977404
175Abnormality of renal resorption (HP:0011038)1.62718121
176Increased intramyocellular lipid droplets (HP:0012240)1.62647276
177Abnormality of the duodenum (HP:0002246)1.62447429
178Recurrent bacterial skin infections (HP:0005406)1.61483812
179Pancreatic fibrosis (HP:0100732)1.61042945
180Embryonal renal neoplasm (HP:0011794)1.60169730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.74183371
2STK165.30719349
3ZAK3.43274193
4IRAK42.88978935
5TXK2.60752107
6TNIK2.56201895
7IRAK32.39733441
8EIF2AK22.37294358
9TEC2.15520942
10MAP3K142.05144628
11VRK12.01372437
12ADRBK21.82353786
13BLK1.81619735
14MAP2K31.76580494
15ADRBK11.65802144
16TIE11.61374672
17WNK41.60077428
18CASK1.59103643
19SRPK11.56197445
20MAP3K31.55947224
21MUSK1.55220777
22GRK11.51799252
23NEK61.50745099
24NUAK11.49563839
25PINK11.48172776
26MAP4K21.47893418
27SGK4941.46438153
28SGK2231.46438153
29TLK11.45830881
30EIF2AK31.43378139
31KIT1.42520662
32NTRK31.42391863
33INSRR1.40448745
34YES11.40022074
35EIF2AK11.38368193
36CDK91.34456165
37OXSR11.32555449
38PBK1.31732233
39FLT31.31689390
40NTRK21.31537199
41MKNK21.29449665
42TAOK31.26186011
43MAP4K11.23229276
44AKT31.22341036
45BRSK21.18006745
46RPS6KB21.17303069
47CDC71.14518771
48PLK41.12933246
49BMPR1B1.09993945
50ATR1.09468666
51BTK1.08257165
52BRAF1.07000613
53NME21.06944416
54MKNK11.03884960
55FGR1.03876194
56TGFBR10.97629719
57MAP2K70.96363774
58IRAK10.95518674
59JAK30.93921135
60IRAK20.93362975
61DAPK20.92649745
62MAP2K10.91631143
63CDK30.91526818
64PIK3CA0.88798406
65SIK30.87921263
66BMPR20.87373196
67DYRK30.86837956
68IKBKE0.84459146
69CCNB10.83546780
70TTK0.82350634
71MAP3K130.82047561
72GRK70.81305383
73IKBKB0.77491215
74MAP3K40.76653699
75ACVR1B0.73882884
76LYN0.73869775
77PRKCE0.73853260
78ITK0.73732611
79TRPM70.73207846
80WEE10.72970996
81NEK90.72205531
82NLK0.71821241
83PIM20.70964973
84STK390.70919336
85MAPK130.69481781
86PLK10.69424731
87CAMK10.69298607
88CLK10.68533138
89WNK30.67825478
90SGK20.65748548
91CSNK1A10.64530928
92SGK30.62947226
93OBSCN0.62522875
94CHEK20.62464617
95ERBB30.60940523
96RPS6KA50.60915873
97NEK20.60776976
98SYK0.60172537
99CDK70.59880856
100PKN10.59334858
101PRKAA20.57763821
102MAPK150.55582779
103ZAP700.55376339
104PASK0.55114097
105PRKCI0.54127822
106CAMKK20.52605704
107MAP2K60.52040826
108SGK10.51696234
109MAPKAPK30.51261844
110CDK80.49989037
111STK40.48926458
112PIM10.48368881
113AURKA0.46618839
114SIK20.46201092
115AURKB0.46153333
116RPS6KA60.45263503
117BUB10.44627002
118LCK0.44514409
119PHKG20.44410811
120PHKG10.44410811
121PLK20.43355003
122STK30.43188457
123ATM0.42469976
124PRKAA10.42329691
125MAPK70.42256467
126TYK20.42233965
127DYRK20.41950052
128STK110.41488655
129PAK30.40332809
130CAMK2A0.39852979
131BCKDK0.39749133
132PTK2B0.38904418
133STK38L0.38534878
134PRKCQ0.38473767
135MAPKAPK50.38442854
136PLK30.38244258
137CDK190.37257288
138PRKCG0.36677463
139RPS6KB10.36194360
140CSF1R0.36136576
141CAMK1D0.35858793
142PIK3CG0.35598962
143TAOK20.35576459
144BRD40.35509025
145TNK20.34928794
146PRKACA0.32441849
147PRKCA0.32255553
148TRIM280.31379212

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.38936653
2Fanconi anemia pathway_Homo sapiens_hsa034603.32137009
3Selenocompound metabolism_Homo sapiens_hsa004503.24944146
4Homologous recombination_Homo sapiens_hsa034403.04454011
5Mismatch repair_Homo sapiens_hsa034302.96334128
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.76689283
7Nitrogen metabolism_Homo sapiens_hsa009102.60284432
8Nicotine addiction_Homo sapiens_hsa050332.48165738
9Base excision repair_Homo sapiens_hsa034102.34727929
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25638347
11Pyrimidine metabolism_Homo sapiens_hsa002402.22880153
12Nucleotide excision repair_Homo sapiens_hsa034202.15518756
13RNA polymerase_Homo sapiens_hsa030202.10575309
14Morphine addiction_Homo sapiens_hsa050322.01719619
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.96515178
16One carbon pool by folate_Homo sapiens_hsa006701.95088519
17Non-homologous end-joining_Homo sapiens_hsa034501.94847164
18Butanoate metabolism_Homo sapiens_hsa006501.90322097
19Sulfur metabolism_Homo sapiens_hsa009201.90155626
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88591625
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83510217
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80752474
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76956784
24Arginine biosynthesis_Homo sapiens_hsa002201.72090361
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71621671
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67584126
27GABAergic synapse_Homo sapiens_hsa047271.59900208
28Collecting duct acid secretion_Homo sapiens_hsa049661.59407384
29Taste transduction_Homo sapiens_hsa047421.57257876
30Purine metabolism_Homo sapiens_hsa002301.54594617
31Protein export_Homo sapiens_hsa030601.53439841
32Other glycan degradation_Homo sapiens_hsa005111.47502134
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46819041
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44971836
35RNA degradation_Homo sapiens_hsa030181.43421170
36Fatty acid elongation_Homo sapiens_hsa000621.43382440
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.38676537
38Systemic lupus erythematosus_Homo sapiens_hsa053221.36655826
39Basal transcription factors_Homo sapiens_hsa030221.36424748
40Olfactory transduction_Homo sapiens_hsa047401.35174806
41Serotonergic synapse_Homo sapiens_hsa047261.33945374
42Primary immunodeficiency_Homo sapiens_hsa053401.33797604
43Ribosome_Homo sapiens_hsa030101.32109895
44Proteasome_Homo sapiens_hsa030501.28784859
45Asthma_Homo sapiens_hsa053101.24610268
46Hematopoietic cell lineage_Homo sapiens_hsa046401.23324838
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.22580134
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.20016286
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19745434
50Glutamatergic synapse_Homo sapiens_hsa047241.17011529
51Sulfur relay system_Homo sapiens_hsa041221.16597715
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16460216
53Graft-versus-host disease_Homo sapiens_hsa053321.14974155
54Autoimmune thyroid disease_Homo sapiens_hsa053201.14720017
55Measles_Homo sapiens_hsa051621.13132816
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12209677
57Arachidonic acid metabolism_Homo sapiens_hsa005901.11098760
58Allograft rejection_Homo sapiens_hsa053301.10432029
59ABC transporters_Homo sapiens_hsa020101.09833115
60Circadian entrainment_Homo sapiens_hsa047131.09579586
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08968465
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07923637
63Peroxisome_Homo sapiens_hsa041461.07574872
64Herpes simplex infection_Homo sapiens_hsa051681.04946583
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.03354685
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02729511
67Spliceosome_Homo sapiens_hsa030401.02074780
68Folate biosynthesis_Homo sapiens_hsa007901.02036781
69Cell cycle_Homo sapiens_hsa041101.00289002
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00138055
71Steroid biosynthesis_Homo sapiens_hsa001000.99825467
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98504698
73Sphingolipid metabolism_Homo sapiens_hsa006000.98328471
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95724190
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.95446354
76beta-Alanine metabolism_Homo sapiens_hsa004100.93833602
77Oxidative phosphorylation_Homo sapiens_hsa001900.93784948
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89023973
79Parkinsons disease_Homo sapiens_hsa050120.84737231
80Linoleic acid metabolism_Homo sapiens_hsa005910.78875853
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78411210
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78180464
83Vitamin digestion and absorption_Homo sapiens_hsa049770.78031707
84Glycerolipid metabolism_Homo sapiens_hsa005610.77966125
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76956454
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76688469
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75470274
88Propanoate metabolism_Homo sapiens_hsa006400.72617692
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.71580311
90Metabolic pathways_Homo sapiens_hsa011000.70870533
91Retinol metabolism_Homo sapiens_hsa008300.68980901
92Fatty acid biosynthesis_Homo sapiens_hsa000610.68555556
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67977331
94Dopaminergic synapse_Homo sapiens_hsa047280.67242721
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67158655
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66824447
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65660300
98Cholinergic synapse_Homo sapiens_hsa047250.65141413
99Huntingtons disease_Homo sapiens_hsa050160.64907101
100Regulation of autophagy_Homo sapiens_hsa041400.64335422
101Leishmaniasis_Homo sapiens_hsa051400.63861245
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63293202
103Caffeine metabolism_Homo sapiens_hsa002320.63291277
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62820675
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62513322
106Malaria_Homo sapiens_hsa051440.62324247
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61159754
108Fat digestion and absorption_Homo sapiens_hsa049750.61023958
109p53 signaling pathway_Homo sapiens_hsa041150.60631830
110Glutathione metabolism_Homo sapiens_hsa004800.58809361
111Calcium signaling pathway_Homo sapiens_hsa040200.58796815
112Staphylococcus aureus infection_Homo sapiens_hsa051500.56272491
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.55973465
114Ether lipid metabolism_Homo sapiens_hsa005650.54504351
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54297323
116Lysine degradation_Homo sapiens_hsa003100.54218478
117Starch and sucrose metabolism_Homo sapiens_hsa005000.53487033
118Arginine and proline metabolism_Homo sapiens_hsa003300.53044783
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52584167
120Vitamin B6 metabolism_Homo sapiens_hsa007500.52439690
121Chemical carcinogenesis_Homo sapiens_hsa052040.52321370
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.50851563
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50539155
124Influenza A_Homo sapiens_hsa051640.50407088
125Type I diabetes mellitus_Homo sapiens_hsa049400.50287254
126Legionellosis_Homo sapiens_hsa051340.50210809
127Tryptophan metabolism_Homo sapiens_hsa003800.48110937
128RNA transport_Homo sapiens_hsa030130.47045278
129Histidine metabolism_Homo sapiens_hsa003400.45999410
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.44724595
131Rheumatoid arthritis_Homo sapiens_hsa053230.42325054
132Phototransduction_Homo sapiens_hsa047440.41532203
133Alcoholism_Homo sapiens_hsa050340.40694047
134Ovarian steroidogenesis_Homo sapiens_hsa049130.38683368
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.38457477
136Insulin secretion_Homo sapiens_hsa049110.32543670
137Mineral absorption_Homo sapiens_hsa049780.32511289
138Salivary secretion_Homo sapiens_hsa049700.31681446
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30652277
140Dorso-ventral axis formation_Homo sapiens_hsa043200.26285705

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