MTND5P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.86944917
2positive regulation of gamma-delta T cell activation (GO:0046645)5.81626781
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.78417485
4microglial cell activation (GO:0001774)5.63322301
5cellular response to ethanol (GO:0071361)5.45096706
6positive regulation by symbiont of host defense response (GO:0052509)5.25145600
7modulation by symbiont of host defense response (GO:0052031)5.25145600
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.25145600
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.25145600
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.25145600
11modulation by symbiont of host immune response (GO:0052553)5.25145600
12regulation of B cell receptor signaling pathway (GO:0050855)4.85658936
13macrophage activation involved in immune response (GO:0002281)4.81018463
14regulation of interferon-beta biosynthetic process (GO:0045357)4.46581564
15macrophage activation (GO:0042116)4.45302735
16regulation of gamma-delta T cell activation (GO:0046643)4.44313900
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.37374793
18response to host immune response (GO:0052572)4.37374793
19histone H3-K36 demethylation (GO:0070544)4.23039377
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.13638368
21regulation of gamma-delta T cell differentiation (GO:0045586)4.12705203
22negative regulation of interleukin-12 production (GO:0032695)4.08978682
23detection of external biotic stimulus (GO:0098581)4.05728219
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.03345012
25response to host (GO:0075136)4.03345012
26response to host defenses (GO:0052200)4.03345012
27negative regulation of cell killing (GO:0031342)3.95484806
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95484806
29positive regulation of interferon-alpha production (GO:0032727)3.93592952
30cellular extravasation (GO:0045123)3.90495762
31myeloid leukocyte mediated immunity (GO:0002444)3.89660982
32regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.88850387
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87363047
34positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.87307313
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.83810732
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82097520
37regulation of interferon-alpha production (GO:0032647)3.69901519
38protein K48-linked deubiquitination (GO:0071108)3.64785244
39neutrophil mediated immunity (GO:0002446)3.59547763
40B cell receptor signaling pathway (GO:0050853)3.59103935
41hepatocyte apoptotic process (GO:0097284)3.57868877
42detection of other organism (GO:0098543)3.55310112
43protein K11-linked deubiquitination (GO:0035871)3.50761767
44response to type I interferon (GO:0034340)3.50538091
45detection of biotic stimulus (GO:0009595)3.44186693
46interferon-gamma-mediated signaling pathway (GO:0060333)3.43105741
47positive regulation of interferon-beta production (GO:0032728)3.42941525
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.40955448
49cellular response to type I interferon (GO:0071357)3.40315941
50type I interferon signaling pathway (GO:0060337)3.40315941
51negative T cell selection (GO:0043383)3.39837015
52myeloid cell activation involved in immune response (GO:0002275)3.37548716
53negative thymic T cell selection (GO:0045060)3.36934670
54regulation of necroptotic process (GO:0060544)3.31952383
55histone mRNA catabolic process (GO:0071044)3.30730951
56dosage compensation (GO:0007549)3.30170501
57response to peptidoglycan (GO:0032494)3.26761207
58protein K63-linked deubiquitination (GO:0070536)3.22130087
59T-helper 1 type immune response (GO:0042088)3.20356718
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18504175
61neutrophil activation involved in immune response (GO:0002283)3.18147648
62positive T cell selection (GO:0043368)3.16418228
63T cell migration (GO:0072678)3.15483427
64monoubiquitinated protein deubiquitination (GO:0035520)3.14971572
65immunoglobulin mediated immune response (GO:0016064)3.11576107
66positive thymic T cell selection (GO:0045059)3.10482275
67negative regulation of immunoglobulin mediated immune response (GO:0002890)3.10290898
68negative regulation of B cell mediated immunity (GO:0002713)3.10290898
69positive regulation of granulocyte differentiation (GO:0030854)3.08595617
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.07273530
71negative regulation of T cell mediated immunity (GO:0002710)3.06867462
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.06725598
73negative regulation of B cell proliferation (GO:0030889)3.04721150
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04689744
75production of molecular mediator involved in inflammatory response (GO:0002532)3.04355328
76regulation of MHC class I biosynthetic process (GO:0045343)3.03991455
77defense response to protozoan (GO:0042832)3.01861755
78negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.00885367
79histone H3-K4 trimethylation (GO:0080182)2.94003982
80phagocytosis, recognition (GO:0006910)2.92021104
81regulation of interferon-beta production (GO:0032648)2.91738292
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89336163
83establishment of protein localization to Golgi (GO:0072600)2.82006341
84interferon-gamma secretion (GO:0072643)2.80201948
85regulation of regulatory T cell differentiation (GO:0045589)2.80140721
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79674061
87response to interferon-alpha (GO:0035455)2.79605219
88negative regulation of interleukin-17 production (GO:0032700)2.79276038
89eosinophil chemotaxis (GO:0048245)2.77705242
90detection of bacterium (GO:0016045)2.76881005
91regulation of T-helper 2 cell differentiation (GO:0045628)2.76736483
92negative regulation of complement activation (GO:0045916)2.75451768
93regulation of RIG-I signaling pathway (GO:0039535)2.75206625
94regulation of hypersensitivity (GO:0002883)2.74729858
95cytokine secretion (GO:0050663)2.74204930
96mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.70788095
97positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.70788095
98protein targeting to Golgi (GO:0000042)2.70340072
99B cell mediated immunity (GO:0019724)2.69223975
100necrotic cell death (GO:0070265)2.68298587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.85868656
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03347158
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.00369878
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97661899
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.96283872
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.53723977
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25351366
8GATA1_22025678_ChIP-Seq_K562_Human3.05971686
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.94653517
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93520848
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85464614
12RUNX_20019798_ChIP-Seq_JUKART_Human2.77778709
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69702985
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.69420959
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56272012
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38255798
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23997066
18MYB_26560356_Chip-Seq_TH2_Human2.23098084
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19652501
20SCL_19346495_ChIP-Seq_HPC-7_Human2.12705008
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11378328
22SPI1_23127762_ChIP-Seq_K562_Human1.89402739
23VDR_24787735_ChIP-Seq_THP-1_Human1.84769876
24MYB_26560356_Chip-Seq_TH1_Human1.80287641
25SPI1_23547873_ChIP-Seq_NB4_Human1.78023450
26GATA3_27048872_Chip-Seq_THYMUS_Human1.68380081
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61108897
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56162092
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53645735
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51457054
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.51000089
32GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48091907
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46953299
34PU_27001747_Chip-Seq_BMDM_Mouse1.45186591
35AR_21572438_ChIP-Seq_LNCaP_Human1.40487939
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38938982
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.38172716
38VDR_24763502_ChIP-Seq_THP-1_Human1.37518936
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36705590
40GATA3_26560356_Chip-Seq_TH2_Human1.34606755
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33343611
42MAF_26560356_Chip-Seq_TH1_Human1.29889294
43TP53_16413492_ChIP-PET_HCT116_Human1.22721670
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.20933987
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20917629
46GATA2_19941826_ChIP-Seq_K562_Human1.20435432
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.20265666
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.19757901
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19417293
50ER_23166858_ChIP-Seq_MCF-7_Human1.18856651
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.16931675
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16486805
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15629128
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12692500
55GATA1_19941826_ChIP-Seq_K562_Human1.12260111
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.11018055
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10901518
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10369212
59GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10302304
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09472960
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08940356
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08854899
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.08686037
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07600827
65SMRT_27268052_Chip-Seq_Bcells_Human1.07048570
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02927173
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02792161
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02127786
69RUNX1_22412390_ChIP-Seq_EML_Mouse0.96676780
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95990172
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95494475
72KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95236928
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94546900
74TAF15_26573619_Chip-Seq_HEK293_Human0.93193419
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92979062
76EZH2_27294783_Chip-Seq_NPCs_Mouse0.92919090
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92261732
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92261732
79STAT3_23295773_ChIP-Seq_U87_Human0.92066519
80UTX_26944678_Chip-Seq_JUKART_Human0.91831189
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91499942
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.91152049
83TCF7_22412390_ChIP-Seq_EML_Mouse0.90406050
84MAF_26560356_Chip-Seq_TH2_Human0.89219968
85SALL4_22934838_ChIP-ChIP_CD34+_Human0.86304264
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86002614
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85651536
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84814280
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84734636
90TP63_23658742_ChIP-Seq_EP156T_Human0.84673860
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84663792
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83781691
93CBP_20019798_ChIP-Seq_JUKART_Human0.79477094
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79477094
95GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78644527
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78031798
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77784457
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77123853
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.77052732
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76923535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.65940329
2MP0003724_increased_susceptibility_to4.54965505
3MP0008260_abnormal_autophagy3.92591326
4MP0001835_abnormal_antigen_presentation3.65559269
5MP0003787_abnormal_imprinting2.67214113
6MP0003172_abnormal_lysosome_physiology2.60089648
7MP0003656_abnormal_erythrocyte_physiolo2.49759398
8MP0001800_abnormal_humoral_immune2.49655741
9MP0005174_abnormal_tail_pigmentation2.43963158
10MP0009785_altered_susceptibility_to2.35210221
11MP0000015_abnormal_ear_pigmentation2.33266361
12MP0000685_abnormal_immune_system2.32473621
13MP0005451_abnormal_body_composition2.28688251
14MP0008877_abnormal_DNA_methylation2.23864748
15MP0008057_abnormal_DNA_replication2.19563452
16MP0004381_abnormal_hair_follicle2.17391072
17MP0003303_peritoneal_inflammation2.15967882
18MP0002419_abnormal_innate_immunity2.10699649
19MP0002166_altered_tumor_susceptibility2.06719654
20MP0006082_CNS_inflammation2.05396926
21MP0002452_abnormal_antigen_presenting2.01947444
22MP0005025_abnormal_response_to2.01894462
23MP0002723_abnormal_immune_serum2.01351985
24MP0005000_abnormal_immune_tolerance2.00064459
25MP0004883_abnormal_blood_vessel1.99357891
26MP0003221_abnormal_cardiomyocyte_apopto1.97364392
27MP0005310_abnormal_salivary_gland1.92394498
28MP0005671_abnormal_response_to1.89143026
29MP0001790_abnormal_immune_system1.87383806
30MP0005387_immune_system_phenotype1.87383806
31MP0003191_abnormal_cellular_cholesterol1.83307838
32MP0002420_abnormal_adaptive_immunity1.82045688
33MP0001819_abnormal_immune_cell1.80599177
34MP0003436_decreased_susceptibility_to1.78904720
35MP0002148_abnormal_hypersensitivity_rea1.71179531
36MP0003763_abnormal_thymus_physiology1.68351184
37MP0002332_abnormal_exercise_endurance1.63676126
38MP0002398_abnormal_bone_marrow1.57487437
39MP0005164_abnormal_response_to1.55327289
40MP0003183_abnormal_peptide_metabolism1.53665842
41MP0000716_abnormal_immune_system1.52459440
42MP0004484_altered_response_of1.51278984
43MP0002396_abnormal_hematopoietic_system1.48456276
44MP0005075_abnormal_melanosome_morpholog1.46380585
45MP0002006_tumorigenesis1.40781588
46MP0005464_abnormal_platelet_physiology1.40542769
47MP0003828_pulmonary_edema1.37681600
48MP0003690_abnormal_glial_cell1.37273519
49MP0002405_respiratory_system_inflammati1.36881953
50MP0005397_hematopoietic_system_phenotyp1.33665914
51MP0001545_abnormal_hematopoietic_system1.33665914
52MP0004808_abnormal_hematopoietic_stem1.33417345
53MP0000689_abnormal_spleen_morphology1.29881160
54MP0002722_abnormal_immune_system1.27860559
55MP0001845_abnormal_inflammatory_respons1.27674909
56MP0004947_skin_inflammation1.26694023
57MP0003632_abnormal_nervous_system1.26550323
58MP0003300_gastrointestinal_ulcer1.21157170
59MP0006054_spinal_hemorrhage1.20799299
60MP0002429_abnormal_blood_cell1.17039770
61MP0003091_abnormal_cell_migration1.14949584
62MP0000703_abnormal_thymus_morphology1.13714547
63MP0009764_decreased_sensitivity_to1.13525247
64MP0009278_abnormal_bone_marrow1.10022197
65MP0001533_abnormal_skeleton_physiology1.07279659
66MP0000604_amyloidosis1.07132767
67MP0004130_abnormal_muscle_cell0.99633241
68MP0005076_abnormal_cell_differentiation0.97904005
69MP0000371_diluted_coat_color0.97714532
70MP0003646_muscle_fatigue0.93030436
71MP0000858_altered_metastatic_potential0.92888345
72MP0002277_abnormal_respiratory_mucosa0.92474974
73MP0008469_abnormal_protein_level0.90680038
74MP0003866_abnormal_defecation0.86106973
75MP0002009_preneoplasia0.85315473
76MP0002909_abnormal_adrenal_gland0.85297830
77MP0000427_abnormal_hair_cycle0.84662419
78MP0003195_calcinosis0.83832780
79MP0005376_homeostasis/metabolism_phenot0.82857165
80MP0010155_abnormal_intestine_physiology0.81869424
81MP0005266_abnormal_metabolism0.78329261
82MP0009765_abnormal_xenobiotic_induced0.77943071
83MP0002132_abnormal_respiratory_system0.76868323
84MP0009763_increased_sensitivity_to0.76430174
85MP0002998_abnormal_bone_remodeling0.74107677
86MP0008874_decreased_physiological_sensi0.74015214
87MP0010307_abnormal_tumor_latency0.72112856
88MP0005621_abnormal_cell_physiology0.69265480
89MP0003121_genomic_imprinting0.68175161
90MP0001851_eye_inflammation0.67278529
91MP0000249_abnormal_blood_vessel0.67084234
92MP0004043_abnormal_pH_regulation0.66643047
93MP0003045_fibrosis0.66075389
94MP0003631_nervous_system_phenotype0.65534848
95MP0005584_abnormal_enzyme/coenzyme_acti0.64514544
96MP0003329_amyloid_beta_deposits0.62792226
97MP0003448_altered_tumor_morphology0.62546575
98MP0005410_abnormal_fertilization0.62251319
99MP0002019_abnormal_tumor_incidence0.61928891
100MP0005409_darkened_coat_color0.61666931

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.61182654
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.41767644
3Recurrent abscess formation (HP:0002722)5.41299012
4Postural instability (HP:0002172)4.64646302
5T lymphocytopenia (HP:0005403)4.62536883
6Abnormality of T cell number (HP:0011839)4.57938667
7Optic neuritis (HP:0100653)4.54665011
8Retrobulbar optic neuritis (HP:0100654)4.54665011
9Gastrointestinal infarctions (HP:0005244)4.43401574
10Recurrent skin infections (HP:0001581)4.29837131
11Eczematoid dermatitis (HP:0000976)4.24665827
12Orchitis (HP:0100796)4.10999295
13Chronic mucocutaneous candidiasis (HP:0002728)4.10086604
14Recurrent cutaneous fungal infections (HP:0011370)4.10086604
15Gingivitis (HP:0000230)4.04923757
16Peritonitis (HP:0002586)3.98765849
17Recurrent fungal infections (HP:0002841)3.95781318
18Myositis (HP:0100614)3.91570147
19Genetic anticipation (HP:0003743)3.87522870
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.56844140
21Resting tremor (HP:0002322)3.41474893
22Visual hallucinations (HP:0002367)3.34284233
23Gingival bleeding (HP:0000225)3.28171345
24Arterial thrombosis (HP:0004420)3.22844441
25Keratoconjunctivitis sicca (HP:0001097)3.15460446
26Recurrent viral infections (HP:0004429)3.10543366
27Recurrent gram-negative bacterial infections (HP:0005420)3.02240035
28Periodontitis (HP:0000704)3.01633446
29Abnormality of T cells (HP:0002843)2.99165573
30Encephalitis (HP:0002383)2.97606959
31Slow saccadic eye movements (HP:0000514)2.83136454
32Keratoconjunctivitis (HP:0001096)2.80938202
33Mediastinal lymphadenopathy (HP:0100721)2.80198414
34Stomatitis (HP:0010280)2.75632673
35Meningitis (HP:0001287)2.75078257
36Hemoptysis (HP:0002105)2.73563057
37Abnormality of the fingertips (HP:0001211)2.70380031
38Chest pain (HP:0100749)2.65465947
39Progressive cerebellar ataxia (HP:0002073)2.61890334
40Viral hepatitis (HP:0006562)2.61760010
41Colitis (HP:0002583)2.60890359
42Inflammation of the large intestine (HP:0002037)2.58938295
43Recurrent bronchitis (HP:0002837)2.53850193
44Gaze-evoked nystagmus (HP:0000640)2.51729541
45Acute hepatic failure (HP:0006554)2.51152133
46Abnormality of macrophages (HP:0004311)2.50336462
47Leukocytosis (HP:0001974)2.49853005
48Elevated erythrocyte sedimentation rate (HP:0003565)2.49285453
49Vasculitis (HP:0002633)2.47257556
50Spontaneous hematomas (HP:0007420)2.47086912
51Abnormality of the peritoneum (HP:0002585)2.45395505
52Autoimmune thrombocytopenia (HP:0001973)2.44551881
53Acute myeloid leukemia (HP:0004808)2.42897984
54Autoimmune hemolytic anemia (HP:0001890)2.41145965
55Poikilocytosis (HP:0004447)2.40644978
56Pustule (HP:0200039)2.35265122
57Panhypogammaglobulinemia (HP:0003139)2.32821203
58Gastrointestinal inflammation (HP:0004386)2.31079919
59Urticaria (HP:0001025)2.29575776
60Epistaxis (HP:0000421)2.28417757
61Eosinophilia (HP:0001880)2.26290360
62Dysmetric saccades (HP:0000641)2.19953748
63Abnormality of the endocardium (HP:0004306)2.18565780
64Subacute progressive viral hepatitis (HP:0006572)2.17886157
65Pulmonary infiltrates (HP:0002113)2.14854417
66Cellulitis (HP:0100658)2.13140066
67IgA deficiency (HP:0002720)2.09079326
68Truncal obesity (HP:0001956)2.08829629
69Abnormality of T cell physiology (HP:0011840)2.08518251
70Neoplasm of the tracheobronchial system (HP:0100552)2.07712544
71Chronic otitis media (HP:0000389)2.07633216
72Cheilitis (HP:0100825)2.06444341
73Anorexia (HP:0002039)2.05814802
74Cerebral inclusion bodies (HP:0100314)2.01121850
75Gangrene (HP:0100758)1.93795155
76Obstructive lung disease (HP:0006536)1.93267990
77Chronic obstructive pulmonary disease (HP:0006510)1.93267990
78Granulocytopenia (HP:0001913)1.92901187
79Ocular albinism (HP:0001107)1.91482999
80Tinnitus (HP:0000360)1.88156409
81Urinary bladder sphincter dysfunction (HP:0002839)1.86625304
82Fatigue (HP:0012378)1.86192943
83Pulmonary embolism (HP:0002204)1.86023553
84Stomach cancer (HP:0012126)1.84753862
85Prolonged bleeding time (HP:0003010)1.84503177
86Bradykinesia (HP:0002067)1.83703309
87Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81920203
88Prominent nose (HP:0000448)1.81135159
89Abnormality of eosinophils (HP:0001879)1.79443344
90Amyotrophic lateral sclerosis (HP:0007354)1.77242358
91Osteomyelitis (HP:0002754)1.75525489
92Hyperkalemia (HP:0002153)1.71797840
93Keratitis (HP:0000491)1.71791031
94Dysautonomia (HP:0002459)1.70699034
95Chronic diarrhea (HP:0002028)1.70133888
96Absent speech (HP:0001344)1.70060241
97Papillary thyroid carcinoma (HP:0002895)1.68266802
98Choroideremia (HP:0001139)1.68023234
99Conjunctival telangiectasia (HP:0000524)1.67948033
100Myocardial infarction (HP:0001658)1.67656589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.22478855
2RIPK43.39546388
3FGR2.46117700
4IKBKE2.43651898
5FRK2.38085212
6JAK12.31683395
7GRK62.27406492
8IRAK42.23218366
9CSK2.19512626
10JAK32.09610997
11PIK3CG2.08722729
12WNK12.06034124
13CDK122.04453955
14TYK21.95618591
15MAP3K141.93458757
16TXK1.92230144
17SYK1.89447197
18PTK2B1.75046892
19MAP2K31.69321723
20FES1.65198690
21FGFR31.61991310
22ACVR1B1.60697351
23BMPR21.57188730
24MAP4K11.53457559
25MAP3K61.52387417
26MAP3K21.48495632
27BTK1.46764096
28TAOK31.45431437
29TEC1.45153598
30SGK21.41396574
31IRAK11.38919018
32STK41.31565266
33JAK21.29198738
34ERBB21.27395416
35GRK51.22829459
36LYN1.20398726
37CAMK1D1.20213354
38KSR11.16539224
39ITK1.15952910
40CAMK1G1.14393720
41ZAP701.12815166
42KIT1.12420722
43HCK1.07367966
44PLK21.05795786
45FGFR41.05395111
46YES11.01527633
47SGK30.98470440
48MAP3K10.98254952
49IRAK20.97078003
50TRPM70.96272178
51MAP3K130.96033242
52LCK0.90614257
53LRRK20.90075624
54TBK10.89851859
55EPHA30.89511735
56CAMKK20.85935625
57IKBKB0.84101952
58CSF1R0.83450672
59NLK0.82996462
60BCR0.82840895
61AKT30.80638033
62PKN20.80363403
63CDC42BPA0.79049400
64KSR20.77345572
65SGK2230.76142397
66SGK4940.76142397
67MARK20.75747492
68PIM10.74107391
69CHUK0.72464481
70MATK0.70086600
71NEK60.65191954
72SGK10.63219839
73BRD40.60041267
74TNK20.59264393
75MARK30.58761932
76STK380.57729280
77MAP3K50.57436093
78RET0.55197033
79EGFR0.55095753
80BMPR1B0.54539936
81EPHB10.53407390
82MAP2K40.53205677
83RAF10.52623839
84MELK0.52139440
85DYRK1A0.50204909
86CLK10.48052815
87ADRBK10.47711967
88PDK10.47466168
89CDK40.46317721
90PRKAA20.45557763
91CAMK40.45421782
92TRIB30.42910234
93FYN0.41655531
94STK110.40717224
95MAP2K60.39406384
96CDK60.38883292
97NEK90.37675824
98MAP3K40.37212731
99PDGFRB0.37051129
100CDK30.36092075

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.06477450
2Staphylococcus aureus infection_Homo sapiens_hsa051502.74735966
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.33122192
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.25141013
5B cell receptor signaling pathway_Homo sapiens_hsa046622.23839162
6Osteoclast differentiation_Homo sapiens_hsa043802.20570470
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17007152
8Graft-versus-host disease_Homo sapiens_hsa053322.13699158
9Tuberculosis_Homo sapiens_hsa051522.05429233
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97387623
11Allograft rejection_Homo sapiens_hsa053301.95440796
12Influenza A_Homo sapiens_hsa051641.92910472
13Measles_Homo sapiens_hsa051621.90995982
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83574016
15Autoimmune thyroid disease_Homo sapiens_hsa053201.82020722
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80508612
17Type I diabetes mellitus_Homo sapiens_hsa049401.77230206
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73756641
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62086264
20Chemokine signaling pathway_Homo sapiens_hsa040621.60836888
21Toxoplasmosis_Homo sapiens_hsa051451.58922817
22Non-small cell lung cancer_Homo sapiens_hsa052231.56091478
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.51666834
24T cell receptor signaling pathway_Homo sapiens_hsa046601.48151553
25Malaria_Homo sapiens_hsa051441.45307806
26Legionellosis_Homo sapiens_hsa051341.42718277
27Asthma_Homo sapiens_hsa053101.40962574
28Antigen processing and presentation_Homo sapiens_hsa046121.40846586
29Herpes simplex infection_Homo sapiens_hsa051681.39913395
30Primary immunodeficiency_Homo sapiens_hsa053401.37367203
31TNF signaling pathway_Homo sapiens_hsa046681.37268482
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.36290599
33Dorso-ventral axis formation_Homo sapiens_hsa043201.30080455
34Hematopoietic cell lineage_Homo sapiens_hsa046401.27670406
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26684228
36Hepatitis C_Homo sapiens_hsa051601.25601097
37Pancreatic cancer_Homo sapiens_hsa052121.20693233
38Hepatitis B_Homo sapiens_hsa051611.19967107
39Acute myeloid leukemia_Homo sapiens_hsa052211.16454053
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14477500
41Prolactin signaling pathway_Homo sapiens_hsa049171.13204583
42Platelet activation_Homo sapiens_hsa046111.11907448
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11321543
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06255210
45Phagosome_Homo sapiens_hsa041451.04026666
46Fatty acid biosynthesis_Homo sapiens_hsa000611.02906943
47Viral myocarditis_Homo sapiens_hsa054161.02445522
48FoxO signaling pathway_Homo sapiens_hsa040681.01593650
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93533642
50Inositol phosphate metabolism_Homo sapiens_hsa005620.92582351
51Apoptosis_Homo sapiens_hsa042100.91952131
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.89085013
53Renal cell carcinoma_Homo sapiens_hsa052110.85083138
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83276709
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81800359
56VEGF signaling pathway_Homo sapiens_hsa043700.81264921
57Chronic myeloid leukemia_Homo sapiens_hsa052200.80351188
58Rheumatoid arthritis_Homo sapiens_hsa053230.79914243
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78810394
60mTOR signaling pathway_Homo sapiens_hsa041500.75587687
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.73207780
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71544265
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69935502
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.69572848
65Epstein-Barr virus infection_Homo sapiens_hsa051690.66716889
66Endometrial cancer_Homo sapiens_hsa052130.66657513
67African trypanosomiasis_Homo sapiens_hsa051430.64853541
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64507501
69HIF-1 signaling pathway_Homo sapiens_hsa040660.64374768
70Insulin resistance_Homo sapiens_hsa049310.62151935
71ABC transporters_Homo sapiens_hsa020100.61934693
72Pertussis_Homo sapiens_hsa051330.59807155
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57806118
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55796643
75Type II diabetes mellitus_Homo sapiens_hsa049300.55761506
76Choline metabolism in cancer_Homo sapiens_hsa052310.55464665
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55191049
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.54044163
79Notch signaling pathway_Homo sapiens_hsa043300.52668042
80ErbB signaling pathway_Homo sapiens_hsa040120.52628646
81Prostate cancer_Homo sapiens_hsa052150.52135798
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51869166
83Lysine degradation_Homo sapiens_hsa003100.51074229
84Glioma_Homo sapiens_hsa052140.50291784
85Shigellosis_Homo sapiens_hsa051310.50145456
86Viral carcinogenesis_Homo sapiens_hsa052030.49599545
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47881502
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47226705
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46559783
90Small cell lung cancer_Homo sapiens_hsa052220.46141903
91GnRH signaling pathway_Homo sapiens_hsa049120.44334700
92Long-term potentiation_Homo sapiens_hsa047200.43584067
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42495863
94Circadian rhythm_Homo sapiens_hsa047100.42210069
95Salmonella infection_Homo sapiens_hsa051320.41623020
96Cholinergic synapse_Homo sapiens_hsa047250.40232409
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.39824913
98Systemic lupus erythematosus_Homo sapiens_hsa053220.38882809
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38323449
100MAPK signaling pathway_Homo sapiens_hsa040100.38141470

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