MTND4P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.33297567
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.20850962
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.82591233
4ATP synthesis coupled proton transport (GO:0015986)5.82591233
5respiratory electron transport chain (GO:0022904)5.57939784
6electron transport chain (GO:0022900)5.48591150
7intestinal absorption (GO:0050892)4.93544169
8respiratory chain complex IV assembly (GO:0008535)4.87250029
9NADH metabolic process (GO:0006734)4.86710597
10positive regulation of respiratory burst (GO:0060267)4.47403790
11oxidative phosphorylation (GO:0006119)4.20738068
12cytochrome complex assembly (GO:0017004)4.05760068
13cytidine deamination (GO:0009972)4.03968331
14cytidine metabolic process (GO:0046087)4.03968331
15cytidine catabolic process (GO:0006216)4.03968331
16regulation of guanylate cyclase activity (GO:0031282)3.99721300
17angiotensin maturation (GO:0002003)3.92506898
18signal transduction involved in regulation of gene expression (GO:0023019)3.75249780
19regulation of mesoderm development (GO:2000380)3.69588281
20hydrogen ion transmembrane transport (GO:1902600)3.65052826
21fucose catabolic process (GO:0019317)3.63042147
22L-fucose metabolic process (GO:0042354)3.63042147
23L-fucose catabolic process (GO:0042355)3.63042147
24ATP biosynthetic process (GO:0006754)3.55501940
25regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.50040965
26regulation of cellular extravasation (GO:0002691)3.46323743
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.45618201
28proton transport (GO:0015992)3.38948512
29epoxygenase P450 pathway (GO:0019373)3.38815598
30phenol-containing compound catabolic process (GO:0019336)3.36134739
31hydrogen transport (GO:0006818)3.31934042
32protein complex biogenesis (GO:0070271)3.17846798
33nodal signaling pathway (GO:0038092)3.17827439
34sulfation (GO:0051923)3.17749681
35aerobic respiration (GO:0009060)3.14918042
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.14252189
37sleep (GO:0030431)3.10558761
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10372034
39receptor guanylyl cyclase signaling pathway (GO:0007168)3.08913420
40mitochondrial respiratory chain complex assembly (GO:0033108)3.06158627
41positive regulation of glycoprotein biosynthetic process (GO:0010560)3.01708039
42regulation of vitamin metabolic process (GO:0030656)2.98367326
43negative regulation of hormone biosynthetic process (GO:0032353)2.96258969
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.96006489
45NADH dehydrogenase complex assembly (GO:0010257)2.96006489
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96006489
47anterior/posterior axis specification, embryo (GO:0008595)2.95987557
48sequestering of extracellular ligand from receptor (GO:0035581)2.91325656
49endoderm formation (GO:0001706)2.90440028
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89477535
51purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86857369
52DNA replication checkpoint (GO:0000076)2.85169599
53negative regulation of hormone metabolic process (GO:0032351)2.82472626
54phospholipid scrambling (GO:0017121)2.79784258
55regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.79193447
56endocrine process (GO:0050886)2.79193447
57regulation of systemic arterial blood pressure by hormone (GO:0001990)2.79193447
58kidney morphogenesis (GO:0060993)2.78356150
59positive regulation of guanylate cyclase activity (GO:0031284)2.75801779
60cellular ketone body metabolic process (GO:0046950)2.73546507
61regulation of systemic arterial blood pressure (GO:0003073)2.73045549
62cobalamin metabolic process (GO:0009235)2.70936465
63regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.69331052
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.67662084
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66912216
66oxaloacetate metabolic process (GO:0006107)2.66758229
67establishment of protein localization to mitochondrial membrane (GO:0090151)2.64124912
68peptide hormone processing (GO:0016486)2.63762703
69dopamine transport (GO:0015872)2.63760986
70fat-soluble vitamin biosynthetic process (GO:0042362)2.62146105
71fucosylation (GO:0036065)2.61738429
72cellular response to zinc ion (GO:0071294)2.61501818
73digestion (GO:0007586)2.59219396
74positive regulation of pseudopodium assembly (GO:0031274)2.58113757
75vitamin biosynthetic process (GO:0009110)2.55500412
76vitamin A metabolic process (GO:0006776)2.54001346
77positive regulation of antigen processing and presentation (GO:0002579)2.53263325
78protein neddylation (GO:0045116)2.52203011
79antigen processing and presentation of endogenous antigen (GO:0019883)2.51764116
80regulation of cGMP biosynthetic process (GO:0030826)2.51725954
81cGMP-mediated signaling (GO:0019934)2.50395577
82regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50165593
83regulation of pseudopodium assembly (GO:0031272)2.48883200
84water-soluble vitamin biosynthetic process (GO:0042364)2.48854719
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47684411
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47365590
87phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.47079390
88glutathione derivative biosynthetic process (GO:1901687)2.45513105
89glutathione derivative metabolic process (GO:1901685)2.45513105
90mesenchymal cell differentiation involved in renal system development (GO:2001012)2.45153812
91mesenchymal cell differentiation involved in kidney development (GO:0072161)2.45153812
92regulation of respiratory burst (GO:0060263)2.42607102
93alkaloid metabolic process (GO:0009820)2.42228330
94regulation of cGMP metabolic process (GO:0030823)2.42113242
95negative regulation of epidermal cell differentiation (GO:0045605)2.41631871
96cellular respiration (GO:0045333)2.40608386
97regulation of cellular respiration (GO:0043457)2.39338071
98thalamus development (GO:0021794)2.38288732
99response to histamine (GO:0034776)2.38014170
100ribonucleoside triphosphate biosynthetic process (GO:0009201)2.37105965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.76150094
2HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.25193565
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89084725
4CDX2_20551321_ChIP-Seq_CACO-2_Human2.88729603
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83311352
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.80536216
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.65805257
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.62744349
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.47580359
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40503795
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.40055968
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.36897010
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32870532
14GATA4_25053715_ChIP-Seq_YYC3_Human2.23094621
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20378141
16BCAT_22108803_ChIP-Seq_LS180_Human2.11524985
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04104236
18GATA1_22025678_ChIP-Seq_K562_Human1.93307245
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89401170
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86509162
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86054202
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78298780
23MYC_18940864_ChIP-ChIP_HL60_Human1.75964337
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73183966
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71343711
26E2F7_22180533_ChIP-Seq_HELA_Human1.63831935
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54883624
28FUS_26573619_Chip-Seq_HEK293_Human1.53766701
29NANOG_20526341_ChIP-Seq_ESCs_Human1.52503516
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51602946
31CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.48570478
32AR_20517297_ChIP-Seq_VCAP_Human1.47475969
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.44258627
34ZNF274_21170338_ChIP-Seq_K562_Hela1.42739090
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.42628181
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42628181
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40949315
38GATA6_25053715_ChIP-Seq_YYC3_Human1.39214363
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38486959
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37610011
41CDX2_22108803_ChIP-Seq_LS180_Human1.34693263
42EWS_26573619_Chip-Seq_HEK293_Human1.34330278
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33135402
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.32973729
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32312382
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32312382
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32312382
48P53_21459846_ChIP-Seq_SAOS-2_Human1.30633193
49MYC_19829295_ChIP-Seq_ESCs_Human1.28962120
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28668996
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.24165923
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23683544
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23513097
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22056794
55FOXP3_21729870_ChIP-Seq_TREG_Human1.20727926
56TTF2_22483619_ChIP-Seq_HELA_Human1.20395809
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.19632573
58RBPJ_21746931_ChIP-Seq_IB4_Human1.18931786
59PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17907817
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17734615
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15148741
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14917046
63ERG_20517297_ChIP-Seq_VCAP_Human1.14539834
64VDR_23849224_ChIP-Seq_CD4+_Human1.14512517
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13452321
66STAT1_20625510_ChIP-Seq_HELA_Human1.13120777
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12808790
68ETV1_20927104_ChIP-Seq_GIST48_Human1.11618612
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.10207642
70TAF2_19829295_ChIP-Seq_ESCs_Human1.09468970
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09274601
72GATA3_26560356_Chip-Seq_TH1_Human1.08648288
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08543344
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06617908
75NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06223802
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05755631
77FOXH1_21741376_ChIP-Seq_ESCs_Human1.05577925
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.05482870
79HOXB7_26014856_ChIP-Seq_BT474_Human1.05378416
80HNFA_21074721_ChIP-Seq_CACO-2_Human1.05041025
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04820572
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04806872
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04629349
84TP53_22573176_ChIP-Seq_HFKS_Human1.02940687
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02569841
86TCF4_22108803_ChIP-Seq_LS180_Human1.01901967
87P300_19829295_ChIP-Seq_ESCs_Human1.01327017
88NCOR_22424771_ChIP-Seq_293T_Human1.01209860
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.01065959
90AR_25329375_ChIP-Seq_VCAP_Human1.00172278
91NANOG_19829295_ChIP-Seq_ESCs_Human1.00106172
92SOX2_19829295_ChIP-Seq_ESCs_Human1.00106172
93NFYB_21822215_ChIP-Seq_K562_Human0.99965981
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99140502
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98863186
96PHF8_20622853_ChIP-Seq_HELA_Human0.98767478
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.98549656
98ELK1_19687146_ChIP-ChIP_HELA_Human0.97901558
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.97826187
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.97745091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.49097028
2MP0009379_abnormal_foot_pigmentation4.38995892
3MP0001666_abnormal_nutrient_absorption2.87274641
4MP0004043_abnormal_pH_regulation2.60753524
5MP0003283_abnormal_digestive_organ2.60493099
6MP0002837_dystrophic_cardiac_calcinosis2.56564869
7MP0002254_reproductive_system_inflammat2.51435648
8MP0004215_abnormal_myocardial_fiber2.41575458
9MP0002139_abnormal_hepatobiliary_system2.29845850
10MP0001188_hyperpigmentation2.27660931
11MP0003806_abnormal_nucleotide_metabolis2.23547422
12MP0001873_stomach_inflammation2.20673424
13MP0006072_abnormal_retinal_apoptosis2.17352903
14MP0006036_abnormal_mitochondrial_physio2.17232632
15MP0004019_abnormal_vitamin_homeostasis2.15043984
16MP0005332_abnormal_amino_acid2.05155769
17MP0002138_abnormal_hepatobiliary_system1.98261958
18MP0008872_abnormal_physiological_respon1.95307281
19MP0002876_abnormal_thyroid_physiology1.91237923
20MP0008775_abnormal_heart_ventricle1.89983022
21MP0010155_abnormal_intestine_physiology1.86477204
22MP0005671_abnormal_response_to1.82919904
23MP0000685_abnormal_immune_system1.77383680
24MP0000013_abnormal_adipose_tissue1.68794611
25MP0003890_abnormal_embryonic-extraembry1.68014401
26MP0010329_abnormal_lipoprotein_level1.67535754
27MP0001664_abnormal_digestion1.60370653
28MP0002396_abnormal_hematopoietic_system1.58860506
29MP0002166_altered_tumor_susceptibility1.58628155
30MP0003693_abnormal_embryo_hatching1.58243237
31MP0003567_abnormal_fetal_cardiomyocyte1.52791853
32MP0005365_abnormal_bile_salt1.51921588
33MP0005085_abnormal_gallbladder_physiolo1.46734787
34MP0003866_abnormal_defecation1.44830547
35MP0005387_immune_system_phenotype1.41686662
36MP0001790_abnormal_immune_system1.41686662
37MP0004145_abnormal_muscle_electrophysio1.37347189
38MP0000490_abnormal_crypts_of1.35869908
39MP0009643_abnormal_urine_homeostasis1.34914646
40MP0001835_abnormal_antigen_presentation1.34583456
41MP0005670_abnormal_white_adipose1.33795257
42MP0000477_abnormal_intestine_morphology1.31989115
43MP0005503_abnormal_tendon_morphology1.31605008
44MP0001765_abnormal_ion_homeostasis1.30945173
45MP0005645_abnormal_hypothalamus_physiol1.29441523
46MP0004147_increased_porphyrin_level1.29414466
47MP0003941_abnormal_skin_development1.25745751
48MP0005636_abnormal_mineral_homeostasis1.24288324
49MP0000230_abnormal_systemic_arterial1.21919055
50MP0002127_abnormal_cardiovascular_syste1.21913903
51MP0004957_abnormal_blastocyst_morpholog1.20086533
52MP0003718_maternal_effect1.19829759
53MP0000462_abnormal_digestive_system1.19625524
54MP0002693_abnormal_pancreas_physiology1.18808383
55MP0003137_abnormal_impulse_conducting1.16840720
56MP0001485_abnormal_pinna_reflex1.16041227
57MP0001756_abnormal_urination1.12056485
58MP0009333_abnormal_splenocyte_physiolog1.11668679
59MP0001544_abnormal_cardiovascular_syste1.11315701
60MP0005385_cardiovascular_system_phenoty1.11315701
61MP0000538_abnormal_urinary_bladder1.11212712
62MP0004085_abnormal_heartbeat1.10729000
63MP0002938_white_spotting1.10308661
64MP0005448_abnormal_energy_balance1.09114029
65MP0001661_extended_life_span1.08830219
66MP0003119_abnormal_digestive_system1.07747968
67MP0001764_abnormal_homeostasis1.06598338
68MP0005330_cardiomyopathy1.06115480
69MP0002006_tumorigenesis1.02116249
70MP0004264_abnormal_extraembryonic_tissu0.98786316
71MP0002909_abnormal_adrenal_gland0.96946199
72MP0000470_abnormal_stomach_morphology0.96522610
73MP0002277_abnormal_respiratory_mucosa0.95997527
74MP0005381_digestive/alimentary_phenotyp0.91746638
75MP0002078_abnormal_glucose_homeostasis0.89777959
76MP0000751_myopathy0.87171450
77MP0010352_gastrointestinal_tract_polyps0.85283034
78MP0009840_abnormal_foam_cell0.83152447
79MP0001944_abnormal_pancreas_morphology0.82871961
80MP0006138_congestive_heart_failure0.82352205
81MP0004885_abnormal_endolymph0.81820451
82MP0001663_abnormal_digestive_system0.81285375
83MP0002118_abnormal_lipid_homeostasis0.79061215
84MP0000631_abnormal_neuroendocrine_gland0.76111789
85MP0005620_abnormal_muscle_contractility0.75940211
86MP0001881_abnormal_mammary_gland0.75869209
87MP0009384_cardiac_valve_regurgitation0.74629762
88MP0002136_abnormal_kidney_physiology0.74027685
89MP0005174_abnormal_tail_pigmentation0.74009780
90MP0005535_abnormal_body_temperature0.72899926
91MP0003953_abnormal_hormone_level0.71552545
92MP0002933_joint_inflammation0.70453869
93MP0003195_calcinosis0.69540198
94MP0000678_abnormal_parathyroid_gland0.69220875
95MP0001800_abnormal_humoral_immune0.69143586
96MP0009642_abnormal_blood_homeostasis0.67496500
97MP0004484_altered_response_of0.66388711
98MP0002102_abnormal_ear_morphology0.64138087
99MP0004084_abnormal_cardiac_muscle0.63968435
100MP0002106_abnormal_muscle_physiology0.63958077

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42122414
2Decreased circulating renin level (HP:0003351)4.27681720
3Abnormality of vitamin B metabolism (HP:0004340)4.19801757
4Abnormality of the vitamin B12 metabolism (HP:0004341)3.88328021
5Acute necrotizing encephalopathy (HP:0006965)3.49259311
6Glycosuria (HP:0003076)3.47999153
7Abnormality of urine glucose concentration (HP:0011016)3.47999153
8Hydroxyprolinuria (HP:0003080)3.40543265
9Abnormality of proline metabolism (HP:0010907)3.40543265
10Hypoglycemic coma (HP:0001325)3.24299269
11Megaloblastic anemia (HP:0001889)3.22562431
12Mitochondrial inheritance (HP:0001427)3.13054661
13Hyperinsulinemic hypoglycemia (HP:0000825)3.11486511
14Congenital, generalized hypertrichosis (HP:0004540)3.11059084
15Acute encephalopathy (HP:0006846)3.04162020
16Abnormal mitochondria in muscle tissue (HP:0008316)2.97987554
17Abnormality of vitamin metabolism (HP:0100508)2.93318950
18Hepatic necrosis (HP:0002605)2.86554709
19Macrocytic anemia (HP:0001972)2.85922915
20Progressive macrocephaly (HP:0004481)2.83124936
21Abnormality of renin-angiotensin system (HP:0000847)2.79444902
22Increased CSF lactate (HP:0002490)2.74098804
23Malnutrition (HP:0004395)2.69290966
24Short hallux (HP:0010109)2.65871111
25Hypoglycemic seizures (HP:0002173)2.60449851
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59950235
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58518761
28Nausea (HP:0002018)2.57149315
29Metabolic alkalosis (HP:0200114)2.56469268
30Facial shape deformation (HP:0011334)2.54853962
31Potter facies (HP:0002009)2.54853962
32Hepatocellular necrosis (HP:0001404)2.53843259
33Congenital sensorineural hearing impairment (HP:0008527)2.53010210
34Dicarboxylic aciduria (HP:0003215)2.52656198
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52656198
36Lipid accumulation in hepatocytes (HP:0006561)2.50725627
37Symptomatic seizures (HP:0011145)2.49569552
38Abnormal number of erythroid precursors (HP:0012131)2.48188157
39Cerebral edema (HP:0002181)2.47109924
40Increased hepatocellular lipid droplets (HP:0006565)2.45531542
41Hyperuricemia (HP:0002149)2.43278295
42Increased purine levels (HP:0004368)2.43278295
43Aplasia/Hypoplasia of the hallux (HP:0008362)2.39628927
44Gout (HP:0001997)2.39453936
45Large for gestational age (HP:0001520)2.39421143
46Hyperglycinuria (HP:0003108)2.38087019
47Palpitations (HP:0001962)2.37018327
48Abnormality of homocysteine metabolism (HP:0010919)2.34670176
49Homocystinuria (HP:0002156)2.34670176
50Late onset (HP:0003584)2.32211382
51Congenital malformation of the right heart (HP:0011723)2.26632874
52Double outlet right ventricle (HP:0001719)2.26632874
53Widely patent fontanelles and sutures (HP:0004492)2.26056736
54Methylmalonic aciduria (HP:0012120)2.23363563
55Short middle phalanx of the 5th finger (HP:0004220)2.21997182
56Chronic diarrhea (HP:0002028)2.21895025
57Abnormality of T cell physiology (HP:0011840)2.21591568
58Alkalosis (HP:0001948)2.17008465
59Abnormal pancreas size (HP:0012094)2.15425595
60IgG deficiency (HP:0004315)2.14334464
61Confusion (HP:0001289)2.13393795
62Abnormality of cells of the erythroid lineage (HP:0012130)2.11367295
63Hyperglycemia (HP:0003074)2.11138238
64Abnormal albumin level (HP:0012116)2.10185005
65Hypoalbuminemia (HP:0003073)2.10185005
66Lethargy (HP:0001254)2.09403468
67Petechiae (HP:0000967)2.07055604
68Acanthocytosis (HP:0001927)2.05602405
69Cerebral palsy (HP:0100021)2.02656249
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02646650
71Limb dystonia (HP:0002451)2.02644213
72Tongue fasciculations (HP:0001308)2.02218142
73Exertional dyspnea (HP:0002875)1.99824703
74Ileus (HP:0002595)1.98915121
75Methylmalonic acidemia (HP:0002912)1.98271526
76Hyperphosphaturia (HP:0003109)1.95502032
77Hyperphosphatemia (HP:0002905)1.94959136
78Abnormality of glycine metabolism (HP:0010895)1.92516145
79Abnormality of serine family amino acid metabolism (HP:0010894)1.92516145
80Aplasia/hypoplasia of the uterus (HP:0008684)1.91092328
81Calf muscle hypertrophy (HP:0008981)1.90100872
82Atrial fibrillation (HP:0005110)1.88979844
83Lactic acidosis (HP:0003128)1.87404353
84Shawl scrotum (HP:0000049)1.86313566
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84556229
86Metabolic acidosis (HP:0001942)1.84317236
87Reticulocytopenia (HP:0001896)1.82601734
88Increased muscle lipid content (HP:0009058)1.82101085
89Proximal tubulopathy (HP:0000114)1.82066585
90Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81088604
91Unilateral renal agenesis (HP:0000122)1.80084739
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.79340040
93Gastrointestinal stroma tumor (HP:0100723)1.78968781
94Testicular atrophy (HP:0000029)1.78396952
95Rectal fistula (HP:0100590)1.78104752
96Rectovaginal fistula (HP:0000143)1.78104752
97Hypoplasia of the pons (HP:0012110)1.77853668
98Muscle hypertrophy of the lower extremities (HP:0008968)1.77432199
99Patent foramen ovale (HP:0001655)1.76688937
100Aplasia of the musculature (HP:0100854)1.75325850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.08221943
2TNIK3.73918885
3MYLK3.70978764
4AKT33.22036196
5TAOK33.20624624
6VRK22.41855376
7MST42.40096673
8PLK42.27847863
9NME12.18176581
10MAP3K122.08072250
11MAP4K12.07536063
12NUAK12.03347620
13ERN12.02013990
14BUB12.01215521
15BMPR1B1.94766605
16NLK1.91178722
17DMPK1.78699113
18CDK121.67024775
19FRK1.58646736
20GRK11.57181390
21STK241.53020319
22MAPK151.52061067
23MAP3K101.43833387
24ADRBK21.39256285
25PINK11.36217500
26PRKG21.30264039
27TLK11.29849660
28MKNK21.29563239
29TEC1.16242429
30MAP2K21.14143552
31MAP2K61.13657669
32TTK1.12981763
33FGFR41.08443682
34TXK1.07332194
35STK31.02053359
36RIPK41.01660212
37CDC70.98858628
38EPHA30.97591538
39MAPKAPK50.97411268
40BRSK20.96609446
41ITK0.94096955
42KIT0.91523561
43WEE10.90181779
44TAF10.87741387
45TRPM70.86149986
46OXSR10.85014177
47PHKG10.78909168
48PHKG20.78909168
49WNK30.75888915
50NEK20.75076800
51VRK10.75039284
52INSRR0.74537529
53MAPK70.70690639
54STK160.70675807
55FLT30.70235390
56PAK30.69341690
57ERBB40.68608410
58CDK80.67517328
59MAP4K20.65878950
60STK40.63288525
61CDK190.62305107
62FGFR20.60701674
63EIF2AK20.60681548
64CAMK2D0.60627712
65HIPK20.58572367
66EPHB10.57820246
67ADRBK10.57350068
68MAP3K140.56515105
69CDC42BPA0.54962474
70CDK40.52927762
71PTK60.52030200
72SYK0.51626805
73NEK10.51040988
74BRD40.50611953
75MELK0.50106949
76OBSCN0.48877635
77PDK20.48615323
78MST1R0.48190079
79MAP3K70.47928953
80PRKG10.45411014
81IKBKB0.44898856
82WNK40.44718141
83PNCK0.43707612
84CHEK20.43680471
85MAPK110.43536800
86ZAP700.43314792
87PRKAA20.42296094
88MAPKAPK30.42079081
89EPHB20.40752238
90PRKCQ0.40404917
91RPS6KA60.40190823
92MAPK120.39851490
93PRKCE0.36277831
94ZAK0.35998198
95PTK2B0.34555178
96MAPKAPK20.34293381
97DAPK20.34065430
98JAK30.33194928
99PRKCA0.30942490
100STK100.30687203

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.16144357
2Asthma_Homo sapiens_hsa053103.02103793
3Sulfur metabolism_Homo sapiens_hsa009203.01440741
4Vitamin digestion and absorption_Homo sapiens_hsa049773.00664325
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.86751978
6Fat digestion and absorption_Homo sapiens_hsa049752.85934743
7Oxidative phosphorylation_Homo sapiens_hsa001902.85591065
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.82994332
9Parkinsons disease_Homo sapiens_hsa050122.48949338
10Type I diabetes mellitus_Homo sapiens_hsa049402.31765263
11Allograft rejection_Homo sapiens_hsa053302.24527874
12Mineral absorption_Homo sapiens_hsa049782.09644685
13Autoimmune thyroid disease_Homo sapiens_hsa053202.08295528
14Renin-angiotensin system_Homo sapiens_hsa046142.02868205
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97036725
16Graft-versus-host disease_Homo sapiens_hsa053321.94579406
17Cardiac muscle contraction_Homo sapiens_hsa042601.82413907
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71329787
19Protein export_Homo sapiens_hsa030601.68244488
20Tryptophan metabolism_Homo sapiens_hsa003801.68005672
21Protein digestion and absorption_Homo sapiens_hsa049741.66278285
22Ribosome_Homo sapiens_hsa030101.59114743
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58484588
24Linoleic acid metabolism_Homo sapiens_hsa005911.57312550
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47344611
26Proteasome_Homo sapiens_hsa030501.46868532
27Alzheimers disease_Homo sapiens_hsa050101.44455841
28Folate biosynthesis_Homo sapiens_hsa007901.42157372
29Homologous recombination_Homo sapiens_hsa034401.36765606
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33925435
31Caffeine metabolism_Homo sapiens_hsa002321.25937579
32Huntingtons disease_Homo sapiens_hsa050161.24708433
33Glutathione metabolism_Homo sapiens_hsa004801.23842033
34Chemical carcinogenesis_Homo sapiens_hsa052041.23589100
35One carbon pool by folate_Homo sapiens_hsa006701.20886748
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17839853
37Retinol metabolism_Homo sapiens_hsa008301.17693929
38Fatty acid degradation_Homo sapiens_hsa000711.17002360
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15934537
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13088218
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11678836
42Primary immunodeficiency_Homo sapiens_hsa053401.10035175
43Arachidonic acid metabolism_Homo sapiens_hsa005901.09823996
44Arginine biosynthesis_Homo sapiens_hsa002201.08108377
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05037561
46Histidine metabolism_Homo sapiens_hsa003401.04803833
47Insulin secretion_Homo sapiens_hsa049110.99054084
48Butanoate metabolism_Homo sapiens_hsa006500.92674677
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92027363
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91536505
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90988650
52Fructose and mannose metabolism_Homo sapiens_hsa000510.90469757
53Antigen processing and presentation_Homo sapiens_hsa046120.87305944
54Starch and sucrose metabolism_Homo sapiens_hsa005000.86096654
55Glycerolipid metabolism_Homo sapiens_hsa005610.85438599
56Selenocompound metabolism_Homo sapiens_hsa004500.85229722
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82953532
58PPAR signaling pathway_Homo sapiens_hsa033200.82044670
59RNA degradation_Homo sapiens_hsa030180.75292697
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71806030
61Viral myocarditis_Homo sapiens_hsa054160.71333836
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.71030641
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69764790
64Arginine and proline metabolism_Homo sapiens_hsa003300.65577263
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65212124
66Propanoate metabolism_Homo sapiens_hsa006400.64594136
67Pyruvate metabolism_Homo sapiens_hsa006200.64155519
68Ether lipid metabolism_Homo sapiens_hsa005650.61564886
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.57997934
70Fatty acid metabolism_Homo sapiens_hsa012120.57415295
71Bile secretion_Homo sapiens_hsa049760.57091436
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56568113
73Renin secretion_Homo sapiens_hsa049240.55913582
74Mismatch repair_Homo sapiens_hsa034300.52953284
75Collecting duct acid secretion_Homo sapiens_hsa049660.52551406
76Pancreatic secretion_Homo sapiens_hsa049720.52044431
77Cocaine addiction_Homo sapiens_hsa050300.51609854
78RNA polymerase_Homo sapiens_hsa030200.51512691
79Rheumatoid arthritis_Homo sapiens_hsa053230.51240657
80Fatty acid elongation_Homo sapiens_hsa000620.48473280
81Purine metabolism_Homo sapiens_hsa002300.47023891
82Sulfur relay system_Homo sapiens_hsa041220.46353854
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.45880898
84Metabolic pathways_Homo sapiens_hsa011000.44325867
85Peroxisome_Homo sapiens_hsa041460.43979887
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41796827
87Nitrogen metabolism_Homo sapiens_hsa009100.39800106
88Thyroid hormone synthesis_Homo sapiens_hsa049180.38764252
89Serotonergic synapse_Homo sapiens_hsa047260.36279230
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35716580
91Galactose metabolism_Homo sapiens_hsa000520.35418261
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.32219764
93Leishmaniasis_Homo sapiens_hsa051400.31157634
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30242929
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.28921413
96Amphetamine addiction_Homo sapiens_hsa050310.28408305
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25308827
98DNA replication_Homo sapiens_hsa030300.24740870
99Staphylococcus aureus infection_Homo sapiens_hsa051500.23772494
100Spliceosome_Homo sapiens_hsa030400.23578132

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