MTND1P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of response to food (GO:0032095)6.16385839
2ATP synthesis coupled proton transport (GO:0015986)5.80410012
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.80410012
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.72891867
5cellular response to nitric oxide (GO:0071732)5.72235552
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.56781460
7ribosomal small subunit biogenesis (GO:0042274)4.98967075
8respiratory electron transport chain (GO:0022904)4.88409319
9cellular response to leptin stimulus (GO:0044320)4.83000230
10electron transport chain (GO:0022900)4.79443582
11regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.78661472
12negative regulation of appetite (GO:0032099)4.61147548
13negative regulation of response to food (GO:0032096)4.61147548
14response to leptin (GO:0044321)4.59096434
15neurofilament cytoskeleton organization (GO:0060052)4.52938074
16viral transcription (GO:0019083)4.52132655
17cellular response to oxygen radical (GO:0071450)4.46615892
18removal of superoxide radicals (GO:0019430)4.46615892
19cellular response to superoxide (GO:0071451)4.46615892
20cellular response to cadmium ion (GO:0071276)4.42518246
21translational termination (GO:0006415)4.32392006
22positive regulation of potassium ion transmembrane transport (GO:1901381)4.29295200
23chaperone-mediated protein transport (GO:0072321)4.27252323
24sterol catabolic process (GO:0016127)4.24761848
25cholesterol catabolic process (GO:0006707)4.24761848
26glutamate secretion (GO:0014047)4.16182264
27negative regulation of necrotic cell death (GO:0060547)4.14358325
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.11543965
29response to nitric oxide (GO:0071731)4.06250480
30protein complex biogenesis (GO:0070271)4.03937852
31astrocyte development (GO:0014002)4.01920982
32ATP biosynthetic process (GO:0006754)3.91350101
33cellular response to reactive nitrogen species (GO:1902170)3.86396922
34cellular zinc ion homeostasis (GO:0006882)3.85088269
35central nervous system myelination (GO:0022010)3.82805376
36axon ensheathment in central nervous system (GO:0032291)3.82805376
37synaptic vesicle exocytosis (GO:0016079)3.81566547
38regulation of protein glycosylation (GO:0060049)3.74835160
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70460738
40mitochondrial respiratory chain complex assembly (GO:0033108)3.64538823
41positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.62785718
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.60502246
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60088013
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.60088013
45NADH dehydrogenase complex assembly (GO:0010257)3.60088013
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.50826057
47activation of protein kinase B activity (GO:0032148)3.50723799
48translational elongation (GO:0006414)3.50658623
49relaxation of smooth muscle (GO:0044557)3.50032952
50response to superoxide (GO:0000303)3.46600218
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43005143
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.42828382
53negative regulation of reactive oxygen species metabolic process (GO:2000378)3.41551704
54protein targeting to ER (GO:0045047)3.37347810
55cotranslational protein targeting to membrane (GO:0006613)3.37087065
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35916033
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35855117
58behavioral response to cocaine (GO:0048148)3.34748591
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.34160279
60substrate-independent telencephalic tangential migration (GO:0021826)3.34160279
61sleep (GO:0030431)3.32980721
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32756326
63response to oxygen radical (GO:0000305)3.30294072
64cellular protein complex disassembly (GO:0043624)3.27221084
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25179833
66protein localization to endoplasmic reticulum (GO:0070972)3.22020602
67hydrogen ion transmembrane transport (GO:1902600)3.16468115
68zinc ion homeostasis (GO:0055069)3.13772418
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.13653667
70oxidative phosphorylation (GO:0006119)3.13148527
71positive regulation of potassium ion transport (GO:0043268)3.12270814
72neuronal action potential propagation (GO:0019227)3.11709382
73cellular potassium ion homeostasis (GO:0030007)3.11091117
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.10906390
75regulation of voltage-gated calcium channel activity (GO:1901385)3.10879466
76urinary tract smooth muscle contraction (GO:0014848)3.10568677
77regulation of sensory perception of pain (GO:0051930)3.10524288
78regulation of sensory perception (GO:0051931)3.10524288
79positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.09744036
80viral life cycle (GO:0019058)3.09719814
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05161862
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.97814243
83regulation of membrane repolarization (GO:0060306)2.97515500
84behavioral fear response (GO:0001662)2.97022952
85behavioral defense response (GO:0002209)2.97022952
86negative regulation of axon extension (GO:0030517)2.96524855
87membrane repolarization (GO:0086009)2.96230613
88regulation of potassium ion transmembrane transport (GO:1901379)2.94537553
89adaptation of signaling pathway (GO:0023058)2.93140581
90startle response (GO:0001964)2.92872963
91detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.90854818
92detection of temperature stimulus involved in sensory perception (GO:0050961)2.90854818
93regulation of appetite (GO:0032098)2.87637148
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87028892
95regulation of potassium ion transport (GO:0043266)2.83011099
96positive regulation of synapse maturation (GO:0090129)2.81411793
97behavioral response to nicotine (GO:0035095)2.80224003
98response to histamine (GO:0034776)2.80103180
99pyrimidine nucleotide catabolic process (GO:0006244)2.79806791
100fear response (GO:0042596)2.78665848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.21696277
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.36944705
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.01776859
4JARID2_20075857_ChIP-Seq_MESCs_Mouse2.91998422
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.86904626
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.80550328
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75115344
8REST_21632747_ChIP-Seq_MESCs_Mouse2.68987980
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61194975
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.60826198
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.60364917
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55114383
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45614436
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45614436
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43776671
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33054584
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.25375305
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16648057
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.15038807
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13881677
21GBX2_23144817_ChIP-Seq_PC3_Human2.12647054
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.12436437
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12002034
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11199384
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.99227931
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95487479
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92153173
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90097987
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85548165
30RNF2_27304074_Chip-Seq_NSC_Mouse1.83355711
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.80273894
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72701358
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71269395
34VDR_22108803_ChIP-Seq_LS180_Human1.67654168
35SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.55919620
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52740506
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52034871
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.51213654
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50891190
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.45578600
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44307871
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37130280
43TAF15_26573619_Chip-Seq_HEK293_Human1.35899301
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34876466
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34128326
46HTT_18923047_ChIP-ChIP_STHdh_Human1.32915402
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31761118
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29096594
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29024409
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27518683
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23216771
52CTCF_27219007_Chip-Seq_Bcells_Human1.21443432
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19581796
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19288193
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17945842
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15798628
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12824229
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12719319
59TAF2_19829295_ChIP-Seq_ESCs_Human1.12369924
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.10506005
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07440422
62FUS_26573619_Chip-Seq_HEK293_Human1.06491267
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.06039204
64CTCF_20526341_ChIP-Seq_ESCs_Human1.05143396
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04116508
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01640093
67MYC_18940864_ChIP-ChIP_HL60_Human0.98884860
68THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98554786
69YY1_21170310_ChIP-Seq_MESCs_Mouse0.97655487
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94613797
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94132176
72DROSHA_22980978_ChIP-Seq_HELA_Human0.93688462
73TP53_22573176_ChIP-Seq_HFKS_Human0.93524295
74P300_19829295_ChIP-Seq_ESCs_Human0.92895296
75EWS_26573619_Chip-Seq_HEK293_Human0.90289437
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.89858706
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88914831
78MYC_19829295_ChIP-Seq_ESCs_Human0.87341018
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.87320220
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85953918
81ERA_21632823_ChIP-Seq_H3396_Human0.85132023
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85071422
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84397969
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84078834
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.83313580
86NCOR_22424771_ChIP-Seq_293T_Human0.82919632
87JUN_21703547_ChIP-Seq_K562_Human0.82374573
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82114608
89RING1B_27294783_Chip-Seq_NPCs_Mouse0.81503277
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81466805
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81313900
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79850549
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78698705
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78650893
95NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78242813
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.78126041
97SMAD4_21799915_ChIP-Seq_A2780_Human0.77704335
98P53_21459846_ChIP-Seq_SAOS-2_Human0.77432593
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77397470
100AR_25329375_ChIP-Seq_VCAP_Human0.76989298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.27788732
2MP0009745_abnormal_behavioral_response3.16316118
3MP0009046_muscle_twitch3.03307736
4MP0002064_seizures3.02400133
5MP0004885_abnormal_endolymph2.91894853
6MP0003787_abnormal_imprinting2.90763462
7MP0003635_abnormal_synaptic_transmissio2.78737260
8MP0002272_abnormal_nervous_system2.67661802
9MP0004859_abnormal_synaptic_plasticity2.64659435
10MP0001188_hyperpigmentation2.57673330
11MP0001968_abnormal_touch/_nociception2.43844495
12MP0008877_abnormal_DNA_methylation2.43318777
13MP0003879_abnormal_hair_cell2.41895618
14MP0003880_abnormal_central_pattern2.34244314
15MP0005646_abnormal_pituitary_gland2.24744103
16MP0003123_paternal_imprinting2.22790807
17MP0006292_abnormal_olfactory_placode2.19269616
18MP0001485_abnormal_pinna_reflex2.04924017
19MP0001905_abnormal_dopamine_level2.01675743
20MP0001486_abnormal_startle_reflex1.99398045
21MP0010386_abnormal_urinary_bladder1.98367921
22MP0002733_abnormal_thermal_nociception1.97699706
23MP0002735_abnormal_chemical_nociception1.94740892
24MP0002063_abnormal_learning/memory/cond1.94521463
25MP0002736_abnormal_nociception_after1.91527151
26MP0005551_abnormal_eye_electrophysiolog1.88143373
27MP0002572_abnormal_emotion/affect_behav1.86287461
28MP0004270_analgesia1.85586179
29MP0005423_abnormal_somatic_nervous1.83421564
30MP0001970_abnormal_pain_threshold1.82027677
31MP0002837_dystrophic_cardiac_calcinosis1.70466192
32MP0001984_abnormal_olfaction1.70414328
33MP0002163_abnormal_gland_morphology1.67575449
34MP0001440_abnormal_grooming_behavior1.66467656
35MP0000955_abnormal_spinal_cord1.65151611
36MP0002234_abnormal_pharynx_morphology1.64877234
37MP0004043_abnormal_pH_regulation1.60983713
38MP0001501_abnormal_sleep_pattern1.57417318
39MP0002734_abnormal_mechanical_nocicepti1.51053824
40MP0000049_abnormal_middle_ear1.49565344
41MP0003011_delayed_dark_adaptation1.48575151
42MP0004742_abnormal_vestibular_system1.48267425
43MP0001963_abnormal_hearing_physiology1.42234341
44MP0006036_abnormal_mitochondrial_physio1.41818024
45MP0004145_abnormal_muscle_electrophysio1.41047207
46MP0002067_abnormal_sensory_capabilities1.34017190
47MP0002557_abnormal_social/conspecific_i1.32866760
48MP0002822_catalepsy1.30707272
49MP0000631_abnormal_neuroendocrine_gland1.27716852
50MP0004142_abnormal_muscle_tone1.24265999
51MP0002160_abnormal_reproductive_system1.19898016
52MP0002882_abnormal_neuron_morphology1.19476709
53MP0006276_abnormal_autonomic_nervous1.18351266
54MP0003633_abnormal_nervous_system1.18198386
55MP0004147_increased_porphyrin_level1.14758502
56MP0000026_abnormal_inner_ear1.13309777
57MP0003121_genomic_imprinting1.12496427
58MP0002638_abnormal_pupillary_reflex1.11718345
59MP0002184_abnormal_innervation1.11504706
60MP0002066_abnormal_motor_capabilities/c1.11186535
61MP0000678_abnormal_parathyroid_gland1.10266403
62MP0004811_abnormal_neuron_physiology1.08130484
63MP0004924_abnormal_behavior1.06382541
64MP0005386_behavior/neurological_phenoty1.06382541
65MP0002752_abnormal_somatic_nervous1.04996957
66MP0005636_abnormal_mineral_homeostasis1.02864111
67MP0001502_abnormal_circadian_rhythm1.02522165
68MP0002229_neurodegeneration1.01771737
69MP0008875_abnormal_xenobiotic_pharmacok1.01740153
70MP0008872_abnormal_physiological_respon0.97731002
71MP0000778_abnormal_nervous_system0.97607022
72MP0005389_reproductive_system_phenotype0.93940622
73MP0003938_abnormal_ear_development0.92489212
74MP0003631_nervous_system_phenotype0.91235894
75MP0003136_yellow_coat_color0.91134154
76MP0008569_lethality_at_weaning0.88671891
77MP0001919_abnormal_reproductive_system0.87399148
78MP0003186_abnormal_redox_activity0.86551858
79MP0005379_endocrine/exocrine_gland_phen0.85130828
80MP0006072_abnormal_retinal_apoptosis0.85001758
81MP0004133_heterotaxia0.84720892
82MP0005332_abnormal_amino_acid0.84689578
83MP0005377_hearing/vestibular/ear_phenot0.83726059
84MP0003878_abnormal_ear_physiology0.83726059
85MP0002277_abnormal_respiratory_mucosa0.81953036
86MP0002876_abnormal_thyroid_physiology0.81104947
87MP0004215_abnormal_myocardial_fiber0.80601984
88MP0003137_abnormal_impulse_conducting0.78183325
89MP0002095_abnormal_skin_pigmentation0.77117233
90MP0005499_abnormal_olfactory_system0.75182288
91MP0005394_taste/olfaction_phenotype0.75182288
92MP0002249_abnormal_larynx_morphology0.74301283
93MP0003122_maternal_imprinting0.74106974
94MP0005195_abnormal_posterior_eye0.72727180
95MP0001664_abnormal_digestion0.71944703
96MP0002152_abnormal_brain_morphology0.71625468
97MP0001765_abnormal_ion_homeostasis0.66258316
98MP0005535_abnormal_body_temperature0.65670463
99MP0009780_abnormal_chondrocyte_physiolo0.65454826
100MP0003646_muscle_fatigue0.65202322

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.72549205
2Myokymia (HP:0002411)4.70262959
3Abnormal mitochondria in muscle tissue (HP:0008316)4.64971638
4Progressive macrocephaly (HP:0004481)3.92937807
5Mitochondrial inheritance (HP:0001427)3.92810686
6Acute encephalopathy (HP:0006846)3.92419807
7Focal seizures (HP:0007359)3.90999902
8Focal motor seizures (HP:0011153)3.82902613
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74241996
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74241996
11Hyperthyroidism (HP:0000836)3.61491808
12Atonic seizures (HP:0010819)3.55223683
13Increased intramyocellular lipid droplets (HP:0012240)3.53831398
14Congenital malformation of the right heart (HP:0011723)3.45152854
15Double outlet right ventricle (HP:0001719)3.45152854
16Renal Fanconi syndrome (HP:0001994)3.39220049
17Action tremor (HP:0002345)3.36414526
18Absence seizures (HP:0002121)3.33905155
19Increased CSF lactate (HP:0002490)3.33356449
20Epileptic encephalopathy (HP:0200134)3.26086720
21Increased muscle lipid content (HP:0009058)3.15769042
22Dialeptic seizures (HP:0011146)3.13247010
23Febrile seizures (HP:0002373)3.10375562
24Increased hepatocellular lipid droplets (HP:0006565)3.04639180
25Ventricular fibrillation (HP:0001663)2.96746404
26Lipid accumulation in hepatocytes (HP:0006561)2.93441559
27Abnormality of renal resorption (HP:0011038)2.84919518
28Hypoplastic left heart (HP:0004383)2.83397283
29Cerebral edema (HP:0002181)2.79089235
30Molar tooth sign on MRI (HP:0002419)2.77003975
31Abnormality of midbrain morphology (HP:0002418)2.77003975
32Macrocytic anemia (HP:0001972)2.76951787
33Generalized tonic-clonic seizures (HP:0002069)2.66875237
34Truncus arteriosus (HP:0001660)2.59460484
35Sclerocornea (HP:0000647)2.48043490
36Limb dystonia (HP:0002451)2.45989895
37Hepatocellular necrosis (HP:0001404)2.45773529
38Leukodystrophy (HP:0002415)2.45465615
39Progressive cerebellar ataxia (HP:0002073)2.44571737
40Abnormality of cells of the erythroid lineage (HP:0012130)2.42273707
41Congenital stationary night blindness (HP:0007642)2.39539306
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.38861951
43Absent/shortened dynein arms (HP:0200106)2.38861951
443-Methylglutaconic aciduria (HP:0003535)2.36541518
45Pancreatic fibrosis (HP:0100732)2.35289916
46Abnormality of binocular vision (HP:0011514)2.35091986
47Diplopia (HP:0000651)2.35091986
48Amblyopia (HP:0000646)2.30082319
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29485934
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27542308
51Lactic acidosis (HP:0003128)2.27387642
52Hepatic necrosis (HP:0002605)2.25017086
53Respiratory failure (HP:0002878)2.24869789
54Status epilepticus (HP:0002133)2.22360626
55Hypoplastic heart (HP:0001961)2.21083901
56X-linked dominant inheritance (HP:0001423)2.16637503
57Agitation (HP:0000713)2.16623759
58Cerebral hypomyelination (HP:0006808)2.16366803
59Pigmentary retinal degeneration (HP:0001146)2.14707047
60Epileptiform EEG discharges (HP:0011182)2.14481984
61Abnormal number of erythroid precursors (HP:0012131)2.10585285
62Hyperphosphaturia (HP:0003109)2.10405837
63Exertional dyspnea (HP:0002875)2.09612749
64Periauricular skin pits (HP:0100277)2.08776861
65Preauricular pit (HP:0004467)2.08776861
66Glycosuria (HP:0003076)2.06699138
67Abnormality of urine glucose concentration (HP:0011016)2.06699138
68Syncope (HP:0001279)2.06306858
69Visual hallucinations (HP:0002367)2.05781871
70Nephronophthisis (HP:0000090)2.02586082
71Anxiety (HP:0000739)2.01597615
72Abnormal drinking behavior (HP:0030082)1.97860096
73Polydipsia (HP:0001959)1.97860096
74Exercise intolerance (HP:0003546)1.97831338
75Optic disc pallor (HP:0000543)1.97685358
76Pallor (HP:0000980)1.94105921
77Medial flaring of the eyebrow (HP:0010747)1.93169842
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93025947
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91536607
80True hermaphroditism (HP:0010459)1.90687438
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89163795
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.89163795
83Increased serum lactate (HP:0002151)1.89141698
84Septo-optic dysplasia (HP:0100842)1.88673864
85Type 2 muscle fiber atrophy (HP:0003554)1.86439019
86Abnormality of magnesium homeostasis (HP:0004921)1.85571983
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85021822
88Nonprogressive disorder (HP:0003680)1.84627863
89Hyperventilation (HP:0002883)1.83892036
90Hypoplasia of the uterus (HP:0000013)1.82507947
91Abnormal eating behavior (HP:0100738)1.82346318
92Respiratory difficulties (HP:0002880)1.79049829
93Abnormal number of incisors (HP:0011064)1.77841898
94Muscle fiber atrophy (HP:0100295)1.77520385
95Abnormal urine phosphate concentration (HP:0012599)1.77233678
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77066580
97Tetany (HP:0001281)1.75171423
98Abnormality of the aortic arch (HP:0012303)1.73724874
99Reticulocytopenia (HP:0001896)1.73560284
100Restlessness (HP:0000711)1.72874628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.45995641
2PINK13.25114976
3NME22.88432860
4NTRK32.68776716
5DMPK2.67125552
6PAK32.44283573
7WNK42.14016621
8PRKCG2.12381684
9CDC71.86316626
10NTRK21.75279291
11UHMK11.74489881
12CASK1.71914080
13DAPK21.68236791
14CAMKK21.67957727
15STK391.65100583
16MINK11.61843550
17EPHA41.59651568
18BUB11.58298586
19TNIK1.55830912
20CAMK2A1.51347996
21ADRBK21.46115449
22MARK11.43086484
23CAMK11.40508741
24GRK51.38438978
25MAP3K41.38364779
26PAK61.37438594
27FRK1.35551515
28CAMK2B1.30900904
29TAF11.27641541
30VRK21.22861355
31DAPK11.18755630
32MAP2K71.17430251
33SGK2231.13839640
34SGK4941.13839640
35PNCK1.13795479
36ABL21.13752300
37CAMK2G1.09381774
38IRAK21.08677562
39CAMKK11.06304304
40NUAK11.05681856
41CAMK2D1.05442359
42RIPK41.05229555
43BRAF1.04492142
44TAOK31.01926312
45PIK3CA1.00163082
46DYRK20.99318645
47GRK10.97474241
48CSNK1E0.96518726
49CSNK1G20.96093015
50CDK50.96091907
51PTK2B0.93918921
52MAP3K90.93447174
53PLK20.89644650
54CDK140.89284255
55TEC0.87953062
56SGK10.87331014
57TLK10.86018422
58BMPR1B0.84384978
59PRKCZ0.84328963
60CDK150.82266995
61PDK20.81256187
62PRKCQ0.80927039
63SGK20.80652930
64CDK11A0.80167137
65STK110.80133522
66MAP3K120.78157885
67MAPKAPK50.77729755
68PRKACA0.73371636
69CDK180.71903042
70AURKA0.71223267
71BCKDK0.71041739
72MAP2K40.70859381
73LIMK10.69268180
74MAPK130.69067798
75CSNK1G30.68739212
76OXSR10.67600958
77DYRK1A0.67042533
78PRKG10.65706706
79ADRBK10.64124020
80CSNK1A10.63646508
81PRKCA0.62430492
82PKN10.62273825
83CSNK2A20.62004926
84ARAF0.61469255
85MAPKAPK30.60718941
86ILK0.60708564
87RPS6KA30.60362812
88MAPK120.60023150
89PAK10.58977405
90CDK190.58225569
91INSRR0.57749375
92MAP3K110.56903880
93PRKCI0.55590975
94DAPK30.55204568
95PRKCD0.54629276
96CSNK1G10.52636060
97CAMK1G0.47838477
98WNK30.47625252
99PRKCH0.47245488
100MAPK100.46439014

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.73758643
2Ribosome_Homo sapiens_hsa030104.60837502
3Parkinsons disease_Homo sapiens_hsa050123.78282072
4Nicotine addiction_Homo sapiens_hsa050333.53874545
5Sulfur relay system_Homo sapiens_hsa041223.52822433
6Alzheimers disease_Homo sapiens_hsa050103.11024294
7Cardiac muscle contraction_Homo sapiens_hsa042602.96755383
8Huntingtons disease_Homo sapiens_hsa050162.48913734
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.44022297
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21444037
11Synaptic vesicle cycle_Homo sapiens_hsa047212.21421121
12Morphine addiction_Homo sapiens_hsa050321.99859156
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84587435
14GABAergic synapse_Homo sapiens_hsa047271.81314265
15Insulin secretion_Homo sapiens_hsa049111.78932160
16Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.78381561
17Folate biosynthesis_Homo sapiens_hsa007901.67350202
18Circadian entrainment_Homo sapiens_hsa047131.65667552
19Collecting duct acid secretion_Homo sapiens_hsa049661.64305246
20Phototransduction_Homo sapiens_hsa047441.53300700
21Amphetamine addiction_Homo sapiens_hsa050311.45983433
22Long-term potentiation_Homo sapiens_hsa047201.42587791
23Dopaminergic synapse_Homo sapiens_hsa047281.41655265
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37852676
25Salivary secretion_Homo sapiens_hsa049701.33688989
26RNA polymerase_Homo sapiens_hsa030201.31715156
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31494575
28Glutamatergic synapse_Homo sapiens_hsa047241.30001112
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25972492
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23425732
31Cocaine addiction_Homo sapiens_hsa050301.18627049
32Gastric acid secretion_Homo sapiens_hsa049711.16570362
33Serotonergic synapse_Homo sapiens_hsa047261.15449173
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.13939896
35Calcium signaling pathway_Homo sapiens_hsa040201.12448347
36Sulfur metabolism_Homo sapiens_hsa009201.11861906
37Cholinergic synapse_Homo sapiens_hsa047251.07974409
38Olfactory transduction_Homo sapiens_hsa047401.07871130
39Taste transduction_Homo sapiens_hsa047421.07471856
40Renin secretion_Homo sapiens_hsa049240.99782178
41Arginine and proline metabolism_Homo sapiens_hsa003300.93612614
42Oxytocin signaling pathway_Homo sapiens_hsa049210.90238076
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88972789
44Pancreatic secretion_Homo sapiens_hsa049720.84941961
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84465240
46Linoleic acid metabolism_Homo sapiens_hsa005910.83377769
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81693471
48Mineral absorption_Homo sapiens_hsa049780.76258555
49Protein export_Homo sapiens_hsa030600.75880904
50cAMP signaling pathway_Homo sapiens_hsa040240.71830164
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65300843
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.64233739
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63312645
54Pyrimidine metabolism_Homo sapiens_hsa002400.60815666
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57411949
56beta-Alanine metabolism_Homo sapiens_hsa004100.55845646
57Long-term depression_Homo sapiens_hsa047300.55761904
58Homologous recombination_Homo sapiens_hsa034400.53040770
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52541085
60Metabolic pathways_Homo sapiens_hsa011000.51395011
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50241961
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49700732
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.48032026
64Regulation of autophagy_Homo sapiens_hsa041400.47812389
65Phenylalanine metabolism_Homo sapiens_hsa003600.47544501
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46566064
67Butanoate metabolism_Homo sapiens_hsa006500.44375425
68Tyrosine metabolism_Homo sapiens_hsa003500.42865062
69Arachidonic acid metabolism_Homo sapiens_hsa005900.42426605
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41902627
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41831920
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40260397
73Tryptophan metabolism_Homo sapiens_hsa003800.38537822
74Chemical carcinogenesis_Homo sapiens_hsa052040.37963755
75Fat digestion and absorption_Homo sapiens_hsa049750.37359453
76Retinol metabolism_Homo sapiens_hsa008300.37271751
77Purine metabolism_Homo sapiens_hsa002300.37114714
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36459919
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36382292
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36326233
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35254926
82Peroxisome_Homo sapiens_hsa041460.35019932
83Asthma_Homo sapiens_hsa053100.31603242
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30844262
85Rheumatoid arthritis_Homo sapiens_hsa053230.30047914
86Histidine metabolism_Homo sapiens_hsa003400.28093927
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25663493
88Gap junction_Homo sapiens_hsa045400.23182620
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.22942595
90Ras signaling pathway_Homo sapiens_hsa040140.20741169
91Bile secretion_Homo sapiens_hsa049760.20380493
92Melanogenesis_Homo sapiens_hsa049160.19432543
93GnRH signaling pathway_Homo sapiens_hsa049120.18287163
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18249302
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16976253
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.15957031
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15687547
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15633357
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14994215
100Basal cell carcinoma_Homo sapiens_hsa052170.14789443

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