MTMR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dicarboxylic acid biosynthetic process (GO:0043650)4.07491785
2regulation of cholesterol esterification (GO:0010872)4.04679250
3histone H3-K36 demethylation (GO:0070544)4.03242390
4nuclear pore complex assembly (GO:0051292)3.98793103
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81258682
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81258682
7antigen processing and presentation of endogenous antigen (GO:0019883)3.68841668
8nuclear pore organization (GO:0006999)3.67622134
9regulation of histone H3-K27 methylation (GO:0061085)3.63753339
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49567634
11thymic T cell selection (GO:0045061)3.47451584
12regulation of RNA export from nucleus (GO:0046831)3.45207940
13kynurenine metabolic process (GO:0070189)3.45088974
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37607735
15B cell receptor signaling pathway (GO:0050853)3.35531752
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.35461158
17negative regulation of cell killing (GO:0031342)3.34302761
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34302761
19alpha-linolenic acid metabolic process (GO:0036109)3.32482711
20indole-containing compound catabolic process (GO:0042436)3.27948685
21indolalkylamine catabolic process (GO:0046218)3.27948685
22tryptophan catabolic process (GO:0006569)3.27948685
23aromatic amino acid family catabolic process (GO:0009074)3.27605990
24regulation of nucleobase-containing compound transport (GO:0032239)3.27003865
25T cell selection (GO:0045058)3.22911486
26positive regulation of gamma-delta T cell activation (GO:0046645)3.21918805
27L-phenylalanine catabolic process (GO:0006559)3.20132697
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.20132697
29positive thymic T cell selection (GO:0045059)3.18937812
30complement activation, alternative pathway (GO:0006957)3.18665370
31urea cycle (GO:0000050)3.15381989
32urea metabolic process (GO:0019627)3.15381989
33protein localization to endosome (GO:0036010)3.13832419
34growth hormone receptor signaling pathway (GO:0060396)3.11012494
35phospholipid efflux (GO:0033700)3.09414750
36positive T cell selection (GO:0043368)3.04936069
37hypotonic response (GO:0006971)3.04532135
38high-density lipoprotein particle remodeling (GO:0034375)3.03617629
39leukocyte aggregation (GO:0070486)3.02857017
40regulation of NFAT protein import into nucleus (GO:0051532)3.00775195
41tryptophan metabolic process (GO:0006568)3.00308007
42negative regulation of erythrocyte differentiation (GO:0045647)2.98706365
43valine metabolic process (GO:0006573)2.96976986
44activation of Rac GTPase activity (GO:0032863)2.95463219
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.94117028
46positive regulation of Cdc42 GTPase activity (GO:0043089)2.93923470
473-UTR-mediated mRNA stabilization (GO:0070935)2.91444084
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90711553
49L-phenylalanine metabolic process (GO:0006558)2.90711553
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.89383116
51RNA stabilization (GO:0043489)2.85404851
52mRNA stabilization (GO:0048255)2.85404851
53regulation of chromatin binding (GO:0035561)2.85088217
54histone H3-K4 trimethylation (GO:0080182)2.84653638
55regulation of interleukin-12 biosynthetic process (GO:0045075)2.84574738
56regulation of gamma-delta T cell differentiation (GO:0045586)2.84294902
57response to muramyl dipeptide (GO:0032495)2.82838796
58histone lysine demethylation (GO:0070076)2.82762162
59hepatocyte apoptotic process (GO:0097284)2.82454429
60bile acid biosynthetic process (GO:0006699)2.82223034
61cell-substrate adherens junction assembly (GO:0007045)2.80626499
62focal adhesion assembly (GO:0048041)2.80626499
63glutamate metabolic process (GO:0006536)2.80346271
64phospholipid homeostasis (GO:0055091)2.78177113
65positive regulation by symbiont of host defense response (GO:0052509)2.76972193
66modulation by symbiont of host defense response (GO:0052031)2.76972193
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76972193
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76972193
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.76972193
70modulation by symbiont of host immune response (GO:0052553)2.76972193
71negative thymic T cell selection (GO:0045060)2.76964289
72reverse cholesterol transport (GO:0043691)2.76047177
73regulation of glucose import in response to insulin stimulus (GO:2001273)2.75431146
74negative T cell selection (GO:0043383)2.74896859
75nitrogen cycle metabolic process (GO:0071941)2.73505252
762-oxoglutarate metabolic process (GO:0006103)2.73306173
77histone H3-K9 demethylation (GO:0033169)2.72805327
78mitotic chromosome condensation (GO:0007076)2.72579103
79regulation of triglyceride catabolic process (GO:0010896)2.72141246
80pore complex assembly (GO:0046931)2.72018160
81detection of other organism (GO:0098543)2.71631228
82regulation of protein activation cascade (GO:2000257)2.70300686
83regulation of ARF protein signal transduction (GO:0032012)2.69877643
84protein localization to microtubule (GO:0035372)2.69075579
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69072036
86positive regulation of B cell differentiation (GO:0045579)2.68260305
87response to laminar fluid shear stress (GO:0034616)2.67195588
88positive regulation of respiratory burst (GO:0060267)2.66556426
89protein-lipid complex remodeling (GO:0034368)2.65546591
90macromolecular complex remodeling (GO:0034367)2.65546591
91plasma lipoprotein particle remodeling (GO:0034369)2.65546591
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64553592
93T-helper cell differentiation (GO:0042093)2.64553592
94detection of bacterium (GO:0016045)2.64523447
95histone demethylation (GO:0016577)2.63485774
96maternal placenta development (GO:0001893)2.63100381
97positive regulation of lipid catabolic process (GO:0050996)2.62484411
98cytoplasmic mRNA processing body assembly (GO:0033962)2.61606417
99regulation of B cell receptor signaling pathway (GO:0050855)2.61155043
100cellular response to growth hormone stimulus (GO:0071378)2.60975286
101peptidyl-threonine modification (GO:0018210)2.59721893
102protein carboxylation (GO:0018214)2.59684465
103peptidyl-glutamic acid carboxylation (GO:0017187)2.59684465
104embryonic process involved in female pregnancy (GO:0060136)2.59466585
105regulation of defense response to virus by virus (GO:0050690)2.58987510
106peptidyl-threonine phosphorylation (GO:0018107)2.57730940
107cellular glucuronidation (GO:0052695)2.56936325
108negative regulation of histone methylation (GO:0031061)2.56570856
109lysine catabolic process (GO:0006554)2.55688422
110lysine metabolic process (GO:0006553)2.55688422
111negative regulation of T cell mediated immunity (GO:0002710)2.54809709
112regulation of gamma-delta T cell activation (GO:0046643)2.54522930
113regulation of complement activation (GO:0030449)2.53670889
114adherens junction assembly (GO:0034333)2.53323643
115mitotic sister chromatid cohesion (GO:0007064)2.51599965
116positive regulation of fatty acid beta-oxidation (GO:0032000)2.51103720
117antigen processing and presentation via MHC class Ib (GO:0002475)2.49482806
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49201608
119intracellular estrogen receptor signaling pathway (GO:0030520)2.49070034
120dosage compensation (GO:0007549)2.49049075
121negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48616068
122negative regulation of sterol transport (GO:0032372)2.48006413
123negative regulation of cholesterol transport (GO:0032375)2.48006413
124cysteine metabolic process (GO:0006534)2.46535431
125DNA unwinding involved in DNA replication (GO:0006268)2.44899249
126B cell homeostasis (GO:0001782)2.44811043
127plasma lipoprotein particle clearance (GO:0034381)2.44113739
128regulation of cholesterol transport (GO:0032374)2.43072086
129regulation of sterol transport (GO:0032371)2.43072086
130regulation of B cell differentiation (GO:0045577)2.42492033
131negative regulation of fibrinolysis (GO:0051918)2.42489770
132glyoxylate metabolic process (GO:0046487)2.42365139
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41581810
134bile acid metabolic process (GO:0008206)2.40910349
135cholesterol efflux (GO:0033344)2.40791701
136cell-substrate junction assembly (GO:0007044)2.39321946
137germinal center formation (GO:0002467)2.39182372
138cellular response to interleukin-15 (GO:0071350)2.38926526
139activation of JUN kinase activity (GO:0007257)2.38392222
140regulation of hypersensitivity (GO:0002883)2.38177812
141cellular modified amino acid catabolic process (GO:0042219)2.37993419
142negative regulation of lymphocyte mediated immunity (GO:0002707)2.37380019
143T cell homeostasis (GO:0043029)2.37348561
144negative regulation of histone modification (GO:0031057)2.36747653
145mammary gland epithelial cell proliferation (GO:0033598)2.36281342
146negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.36280536
147histone H4-K16 acetylation (GO:0043984)2.34631830
148corticosteroid receptor signaling pathway (GO:0031958)2.34558172
149regulation of water loss via skin (GO:0033561)2.33782153
150acylglycerol homeostasis (GO:0055090)2.33735997
151triglyceride homeostasis (GO:0070328)2.33735997
152homocysteine metabolic process (GO:0050667)2.33723925
153protein export from nucleus (GO:0006611)2.33538106
154tolerance induction (GO:0002507)2.33487372
155modulation by symbiont of host cellular process (GO:0044068)2.33052461
156histone H3-K4 methylation (GO:0051568)2.32794988
157positive regulation of keratinocyte differentiation (GO:0045618)2.31944616
158regulation of cholesterol homeostasis (GO:2000188)2.31746030
159glucocorticoid receptor signaling pathway (GO:0042921)2.31227245
160trophectodermal cell differentiation (GO:0001829)2.30998958
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30811471
162regulation of fibrinolysis (GO:0051917)2.30242120
163regulation of necroptotic process (GO:0060544)2.29640093
164sulfur amino acid catabolic process (GO:0000098)2.29249188
165protein dealkylation (GO:0008214)2.28094943
166regulation of fatty acid beta-oxidation (GO:0031998)2.26883858
167cytolysis (GO:0019835)2.26146225
168fatty acid transmembrane transport (GO:1902001)2.26008377
169response to interleukin-15 (GO:0070672)2.25860890
170alpha-beta T cell differentiation involved in immune response (GO:0002293)2.22763089
171alpha-beta T cell activation involved in immune response (GO:0002287)2.22763089
172T cell differentiation involved in immune response (GO:0002292)2.22763089
173regulation of cholesterol storage (GO:0010885)2.20441007
174cellular ketone body metabolic process (GO:0046950)2.18315207
175amino-acid betaine metabolic process (GO:0006577)2.18152631
176negative regulation of lipase activity (GO:0060192)2.17869085
177acute-phase response (GO:0006953)2.17739547
178positive regulation of fatty acid oxidation (GO:0046321)2.17513857
179low-density lipoprotein particle remodeling (GO:0034374)2.17075630
180plasma lipoprotein particle organization (GO:0071827)2.15823713
181positive regulation of cholesterol transport (GO:0032376)2.15778259
182positive regulation of sterol transport (GO:0032373)2.15778259
183mature B cell differentiation (GO:0002335)2.14776645
184interferon-gamma production (GO:0032609)2.14545194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51549109
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.97433536
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.70097559
4E2F7_22180533_ChIP-Seq_HELA_Human3.55967184
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45024513
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19681773
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.17780275
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.90776583
9GATA1_22025678_ChIP-Seq_K562_Human2.80678370
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.76971671
11VDR_21846776_ChIP-Seq_THP-1_Human2.67233522
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49523208
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.48726701
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34453392
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27962717
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.26568989
17RUNX_20019798_ChIP-Seq_JUKART_Human2.15675172
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07410145
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02235545
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00860652
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.00582161
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99164913
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.97495348
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97145492
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93351045
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.88162384
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84236941
28* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79258119
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73800862
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.73744091
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70743555
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67945927
33RACK7_27058665_Chip-Seq_MCF-7_Human1.66256208
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65065035
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63618765
36MAF_26560356_Chip-Seq_TH2_Human1.62374954
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60705107
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57717430
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57184486
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57083556
41KDM2B_26808549_Chip-Seq_K562_Human1.56587435
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56135155
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55631099
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52105827
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49631647
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45845148
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.43272929
48TCF7_22412390_ChIP-Seq_EML_Mouse1.39729648
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39326185
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39071733
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36940825
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36346658
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35824098
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.35536010
55VDR_24787735_ChIP-Seq_THP-1_Human1.35329134
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34755969
57MAF_26560356_Chip-Seq_TH1_Human1.33339163
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32815616
59LXR_22292898_ChIP-Seq_THP-1_Human1.32640317
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30619349
61CLOCK_20551151_ChIP-Seq_293T_Human1.29486754
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28659958
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28606548
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.28298380
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.27445036
66MYB_26560356_Chip-Seq_TH2_Human1.25975541
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.25534015
68GATA3_27048872_Chip-Seq_THYMUS_Human1.25270377
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25083806
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24953104
71SPI1_23547873_ChIP-Seq_NB4_Human1.23176949
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23154785
73* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21571264
74* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21571264
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19521677
76SCL_19346495_ChIP-Seq_HPC-7_Human1.19366656
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19097389
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18163642
79CIITA_25753668_ChIP-Seq_RAJI_Human1.17602525
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16796130
81NCOR1_26117541_ChIP-Seq_K562_Human1.16473961
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16453202
83* MYB_26560356_Chip-Seq_TH1_Human1.16132973
84CHD1_26751641_Chip-Seq_LNCaP_Human1.15673430
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14440116
86KDM2B_26808549_Chip-Seq_DND41_Human1.13869543
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13020109
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12778361
89DROSHA_22980978_ChIP-Seq_HELA_Human1.11785576
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11697869
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10883276
92EGR1_19032775_ChIP-ChIP_M12_Human1.10336848
93SPI1_23127762_ChIP-Seq_K562_Human1.10101158
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07959428
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.06475073
96EZH2_22144423_ChIP-Seq_EOC_Human1.06007220
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05832109
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05724091
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04980727
100ATF3_27146783_Chip-Seq_COLON_Human1.04352011
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03665721
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.03341581
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02624288
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02500438
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01874796
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01689995
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01228243
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00666025
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00045413
110TFEB_21752829_ChIP-Seq_HELA_Human0.99558001
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.99530477
112MYC_22102868_ChIP-Seq_BL_Human0.99161325
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.98950972
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98354643
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97981775
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97969062
117GATA2_19941826_ChIP-Seq_K562_Human0.97236168
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97017862
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96766087
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96544485
121VDR_24763502_ChIP-Seq_THP-1_Human0.95782991
122GATA1_19941826_ChIP-Seq_K562_Human0.94982983
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94317128
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94285622
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94285622
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.93647923
127PU_27001747_Chip-Seq_BMDM_Mouse0.93195232
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92091748
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91715077
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90372790
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89761998
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87631864
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87430640
134AR_21572438_ChIP-Seq_LNCaP_Human0.87252910
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87157263
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87039245
137BCAT_22108803_ChIP-Seq_LS180_Human0.86669894
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84693349
139TAF15_26573619_Chip-Seq_HEK293_Human0.83920084
140UTX_26944678_Chip-Seq_JUKART_Human0.82551076
141TP53_16413492_ChIP-PET_HCT116_Human0.81706441
142AR_25329375_ChIP-Seq_VCAP_Human0.80387767
143RXR_22108803_ChIP-Seq_LS180_Human0.80208778
144GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80144171
145RARB_27405468_Chip-Seq_BRAIN_Mouse0.79723991
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79455338
147GATA3_26560356_Chip-Seq_TH2_Human0.78580920
148CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77266538
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.76434533
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76408332
151TP53_18474530_ChIP-ChIP_U2OS_Human0.76317401
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.75979014
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.75979014
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.75634463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.72565871
2MP0002139_abnormal_hepatobiliary_system3.64539978
3MP0005365_abnormal_bile_salt3.14426019
4MP0001835_abnormal_antigen_presentation2.97482740
5MP0005085_abnormal_gallbladder_physiolo2.89879689
6MP0008057_abnormal_DNA_replication2.89156863
7MP0002166_altered_tumor_susceptibility2.84886599
8MP0000685_abnormal_immune_system2.73976683
9MP0010234_abnormal_vibrissa_follicle2.68392577
10MP0003300_gastrointestinal_ulcer2.62425905
11MP0002396_abnormal_hematopoietic_system2.58919454
12MP0005076_abnormal_cell_differentiation2.57235957
13MP0002138_abnormal_hepatobiliary_system2.50725913
14MP0002009_preneoplasia2.46601127
15MP0002254_reproductive_system_inflammat2.33893202
16MP0005451_abnormal_body_composition2.22921484
17MP0008875_abnormal_xenobiotic_pharmacok2.20234894
18MP0003252_abnormal_bile_duct2.14807729
19MP0003191_abnormal_cellular_cholesterol2.13238446
20MP0005409_darkened_coat_color2.11637318
21MP0010329_abnormal_lipoprotein_level2.11049700
22MP0003436_decreased_susceptibility_to2.07928905
23MP0001790_abnormal_immune_system2.05067728
24MP0005387_immune_system_phenotype2.05067728
25MP0002006_tumorigenesis2.02328090
26MP0004130_abnormal_muscle_cell1.96191186
27MP0003303_peritoneal_inflammation1.93454477
28MP0010352_gastrointestinal_tract_polyps1.91829328
29MP0002877_abnormal_melanocyte_morpholog1.88992188
30MP0003091_abnormal_cell_migration1.87595889
31MP0005671_abnormal_response_to1.86572665
32MP0004381_abnormal_hair_follicle1.84783619
33MP0009333_abnormal_splenocyte_physiolog1.78188805
34MP0001800_abnormal_humoral_immune1.76891472
35MP0003453_abnormal_keratinocyte_physiol1.74241296
36MP0000013_abnormal_adipose_tissue1.73783497
37MP0004808_abnormal_hematopoietic_stem1.72810613
38MP0003566_abnormal_cell_adhesion1.72545075
39MP0000703_abnormal_thymus_morphology1.70759689
40MP0000569_abnormal_digit_pigmentation1.68477993
41MP0004947_skin_inflammation1.67591059
42MP0000604_amyloidosis1.65370533
43MP0004510_myositis1.63768298
44MP0005501_abnormal_skin_physiology1.61753955
45MP0001348_abnormal_lacrimal_gland1.60923237
46MP0004233_abnormal_muscle_weight1.60233082
47MP0004264_abnormal_extraembryonic_tissu1.50862736
48MP0005000_abnormal_immune_tolerance1.50251414
49MP0002723_abnormal_immune_serum1.46461024
50MP0002419_abnormal_innate_immunity1.45746397
51MP0002452_abnormal_antigen_presenting1.45619441
52MP0000609_abnormal_liver_physiology1.45182641
53MP0005332_abnormal_amino_acid1.44879753
54MP0009785_altered_susceptibility_to1.43939904
55MP0005025_abnormal_response_to1.42898615
56MP0008260_abnormal_autophagy1.42774833
57MP0004859_abnormal_synaptic_plasticity1.34907976
58MP0001666_abnormal_nutrient_absorption1.34450746
59MP0005464_abnormal_platelet_physiology1.33289325
60MP0002118_abnormal_lipid_homeostasis1.32672907
61MP0000733_abnormal_muscle_development1.31911566
62MP0001819_abnormal_immune_cell1.30181505
63MP0002420_abnormal_adaptive_immunity1.29993036
64MP0002148_abnormal_hypersensitivity_rea1.29935819
65MP0001216_abnormal_epidermal_layer1.28732095
66MP0009840_abnormal_foam_cell1.27163796
67MP0009764_decreased_sensitivity_to1.25942406
68MP0006082_CNS_inflammation1.25399567
69MP0001873_stomach_inflammation1.24108784
70MP0000858_altered_metastatic_potential1.23958647
71MP0001730_embryonic_growth_arrest1.23635058
72MP0001853_heart_inflammation1.22351606
73MP0005584_abnormal_enzyme/coenzyme_acti1.21961986
74MP0002876_abnormal_thyroid_physiology1.19701798
75MP0004185_abnormal_adipocyte_glucose1.18208245
76MP0008961_abnormal_basal_metabolism1.16106644
77MP0005621_abnormal_cell_physiology1.13171133
78MP0005535_abnormal_body_temperature1.12713259
79MP0000350_abnormal_cell_proliferation1.12678383
80MP0005310_abnormal_salivary_gland1.11158876
81MP0003656_abnormal_erythrocyte_physiolo1.11069992
82MP0000377_abnormal_hair_follicle1.10810203
83MP0000490_abnormal_crypts_of1.09729690
84MP0008469_abnormal_protein_level1.09682848
85MP0001845_abnormal_inflammatory_respons1.07628640
86MP0002098_abnormal_vibrissa_morphology1.06789007
87MP0005319_abnormal_enzyme/_coenzyme1.06541455
88MP0001501_abnormal_sleep_pattern1.05817460
89MP0003763_abnormal_thymus_physiology1.03102187
90MP0002060_abnormal_skin_morphology1.02523303
91MP0001851_eye_inflammation1.02005045
92MP0003868_abnormal_feces_composition1.01690899
93MP0003705_abnormal_hypodermis_morpholog1.01485477
94MP0000579_abnormal_nail_morphology1.01017607
95MP0000716_abnormal_immune_system0.99954323
96MP0010678_abnormal_skin_adnexa0.99571178
97MP0003329_amyloid_beta_deposits0.99462451
98MP0002398_abnormal_bone_marrow0.99111651
99MP0005083_abnormal_biliary_tract0.97245508
100MP0002971_abnormal_brown_adipose0.95419347
101MP0003183_abnormal_peptide_metabolism0.95392314
102MP0010155_abnormal_intestine_physiology0.94271720
103MP0003111_abnormal_nucleus_morphology0.94017978
104MP0001849_ear_inflammation0.93787026
105MP0009931_abnormal_skin_appearance0.92663185
106MP0009278_abnormal_bone_marrow0.90607829
107MP0003075_altered_response_to0.90136462
108MP0009672_abnormal_birth_weight0.90071132
109MP0002086_abnormal_extraembryonic_tissu0.89917569
110MP0005166_decreased_susceptibility_to0.89664234
111MP0010307_abnormal_tumor_latency0.87636596
112MP0003045_fibrosis0.86845859
113MP0003077_abnormal_cell_cycle0.86469826
114MP0009763_increased_sensitivity_to0.85860688
115MP0003984_embryonic_growth_retardation0.85477451
116MP0002909_abnormal_adrenal_gland0.85290819
117MP0003828_pulmonary_edema0.85230331
118MP0005380_embryogenesis_phenotype0.84992412
119MP0001672_abnormal_embryogenesis/_devel0.84992412
120MP0003690_abnormal_glial_cell0.83610257
121MP0002088_abnormal_embryonic_growth/wei0.83195788
122MP0000689_abnormal_spleen_morphology0.80282299
123MP0002019_abnormal_tumor_incidence0.79550494
124MP0002796_impaired_skin_barrier0.77881335
125MP0003866_abnormal_defecation0.77456910
126MP0003195_calcinosis0.77159256
127MP0003172_abnormal_lysosome_physiology0.76891806
128MP0000627_abnormal_mammary_gland0.76561011
129MP0003221_abnormal_cardiomyocyte_apopto0.76376514
130MP0008874_decreased_physiological_sensi0.75866698
131MP0005334_abnormal_fat_pad0.75760038
132MP0005647_abnormal_sex_gland0.75616023
133MP0003633_abnormal_nervous_system0.75606504
134MP0002998_abnormal_bone_remodeling0.75529554
135MP0005666_abnormal_adipose_tissue0.75242010
136MP0000678_abnormal_parathyroid_gland0.74718607
137MP0005023_abnormal_wound_healing0.73615752
138MP0002722_abnormal_immune_system0.72978864
139MP0002405_respiratory_system_inflammati0.71464101
140MP0005275_abnormal_skin_tensile0.70545843
141MP0002429_abnormal_blood_cell0.70448034
142MP0001533_abnormal_skeleton_physiology0.70442788
143MP0005384_cellular_phenotype0.70231293
144MP0001346_abnormal_lacrimal_gland0.70119933
145MP0002080_prenatal_lethality0.69513448
146MP0004019_abnormal_vitamin_homeostasis0.69038412
147MP0004957_abnormal_blastocyst_morpholog0.68962108
148MP0005174_abnormal_tail_pigmentation0.68832285
149MP0000003_abnormal_adipose_tissue0.68532780
150MP0004782_abnormal_surfactant_physiolog0.68087032
151MP0002822_catalepsy0.67261679
152MP0001915_intracranial_hemorrhage0.67152371
153MP0003635_abnormal_synaptic_transmissio0.67141256
154MP0009745_abnormal_behavioral_response0.67090677
155MP0005375_adipose_tissue_phenotype0.65663236

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)4.54253795
2Deep venous thrombosis (HP:0002625)3.75778253
3Xanthomatosis (HP:0000991)3.32827800
4Myocardial infarction (HP:0001658)3.20942505
5Recurrent gram-negative bacterial infections (HP:0005420)3.08699598
6Eczematoid dermatitis (HP:0000976)3.02347301
7Recurrent bacterial skin infections (HP:0005406)2.99574340
8Complement deficiency (HP:0004431)2.99235575
9Abnormality of the common coagulation pathway (HP:0010990)2.96411780
10Epidermoid cyst (HP:0200040)2.89750920
11Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89274986
12Intrahepatic cholestasis (HP:0001406)2.74351804
13Broad face (HP:0000283)2.68266652
14Obstructive sleep apnea (HP:0002870)2.65118439
15Spinal cord lesions (HP:0100561)2.62812202
16Syringomyelia (HP:0003396)2.62812202
17Gingival bleeding (HP:0000225)2.60749985
18Ankyloglossia (HP:0010296)2.59173343
19Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56981669
20Cellulitis (HP:0100658)2.52322720
21Viral hepatitis (HP:0006562)2.48415201
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47873794
23Hyperlipoproteinemia (HP:0010980)2.45593384
24Flat acetabular roof (HP:0003180)2.44420080
25Mitral stenosis (HP:0001718)2.44037605
26Abnormality of the fingertips (HP:0001211)2.42740980
27Prolonged partial thromboplastin time (HP:0003645)2.41717047
28Joint hemorrhage (HP:0005261)2.41582451
29Abnormality of complement system (HP:0005339)2.35831754
30Hyperacusis (HP:0010780)2.35156575
31Recurrent abscess formation (HP:0002722)2.32936961
32Hypobetalipoproteinemia (HP:0003563)2.32820673
33Heterotopia (HP:0002282)2.32266279
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32166372
35Arterial thrombosis (HP:0004420)2.30024564
36Asymmetry of the thorax (HP:0001555)2.27567671
37Recurrent viral infections (HP:0004429)2.26042960
38Hypoalphalipoproteinemia (HP:0003233)2.24516768
39Abnormality of oral frenula (HP:0000190)2.24342945
40Disinhibition (HP:0000734)2.22281000
41Selective tooth agenesis (HP:0001592)2.21990350
42Verrucae (HP:0200043)2.20831482
43Papilloma (HP:0012740)2.20831482
44Entropion (HP:0000621)2.20268231
45Recurrent fungal infections (HP:0002841)2.19776195
46Mediastinal lymphadenopathy (HP:0100721)2.18662377
47Hemorrhage of the eye (HP:0011885)2.17979718
48Hematochezia (HP:0002573)2.17071261
49Increased IgE level (HP:0003212)2.16451692
50Exercise-induced myalgia (HP:0003738)2.14641493
51Abnormal social behavior (HP:0012433)2.13451825
52Impaired social interactions (HP:0000735)2.13451825
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.12260331
54Conjunctival hamartoma (HP:0100780)2.11625348
55Pigmentary retinal degeneration (HP:0001146)2.11499410
56Skin nodule (HP:0200036)2.10783625
57Hypolipoproteinemia (HP:0010981)2.09769283
58Dysmetric saccades (HP:0000641)2.09626917
59Ketosis (HP:0001946)2.09157756
60Germ cell neoplasia (HP:0100728)2.08215342
61Arterial tortuosity (HP:0005116)2.07723724
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.07203964
63Osteolytic defects of the hand bones (HP:0009699)2.07203964
64Deep palmar crease (HP:0006191)2.05082132
65Neonatal hypoglycemia (HP:0001998)2.03948669
66Abnormality of nail color (HP:0100643)2.03654423
67Dislocated radial head (HP:0003083)2.03113588
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.02729928
69Recurrent skin infections (HP:0001581)2.02120159
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02091234
71Long palpebral fissure (HP:0000637)2.01154629
72Pulmonary embolism (HP:0002204)2.00939212
73Abnormality of sulfur amino acid metabolism (HP:0004339)1.98868243
74Myositis (HP:0100614)1.98866348
75Thrombophlebitis (HP:0004418)1.97412105
76Spontaneous abortion (HP:0005268)1.96580396
77Hepatocellular carcinoma (HP:0001402)1.96425283
78Hypoglycemic coma (HP:0001325)1.95535697
79Agammaglobulinemia (HP:0004432)1.95428198
80Poor eye contact (HP:0000817)1.95390744
81Thin bony cortex (HP:0002753)1.95240338
82Dilatation of the ascending aorta (HP:0005111)1.94326061
83Milia (HP:0001056)1.94285226
84Chronic otitis media (HP:0000389)1.93220513
85Macroorchidism (HP:0000053)1.93191771
86Autoimmune thrombocytopenia (HP:0001973)1.92676038
87Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91825975
88Abnormality of the radial head (HP:0003995)1.91280161
89Micronodular cirrhosis (HP:0001413)1.90974508
90Acanthocytosis (HP:0001927)1.90356162
91Colitis (HP:0002583)1.89872514
92Sparse lateral eyebrow (HP:0005338)1.89507129
93Poikiloderma (HP:0001029)1.88919829
94Fatigue (HP:0012378)1.87923356
95Amyloidosis (HP:0011034)1.87468170
96Abnormality of T cell number (HP:0011839)1.87173312
97Polycythemia (HP:0001901)1.86220616
98Inflammation of the large intestine (HP:0002037)1.85413230
99Abnormality of the thoracic spine (HP:0100711)1.84638882
100Chronic mucocutaneous candidiasis (HP:0002728)1.84637694
101Recurrent cutaneous fungal infections (HP:0011370)1.84637694
102Systemic lupus erythematosus (HP:0002725)1.84454278
103Abnormality of the left ventricular outflow tract (HP:0011103)1.84216874
104Subaortic stenosis (HP:0001682)1.84216874
105Inappropriate behavior (HP:0000719)1.83557941
106Distal lower limb amyotrophy (HP:0008944)1.83274454
107Lip pit (HP:0100267)1.83008950
108Vasculitis (HP:0002633)1.79968630
109Deep philtrum (HP:0002002)1.79911794
110Persistence of primary teeth (HP:0006335)1.79896912
111Lower limb hyperreflexia (HP:0002395)1.79888359
112Vascular tortuosity (HP:0004948)1.79825265
113Elevated erythrocyte sedimentation rate (HP:0003565)1.79741951
114Epistaxis (HP:0000421)1.79596138
115Death in childhood (HP:0003819)1.79061253
116Joint swelling (HP:0001386)1.78806501
117Abnormality of fatty-acid metabolism (HP:0004359)1.78668113
118Hypercholesterolemia (HP:0003124)1.78542248
119Osteomyelitis (HP:0002754)1.77877835
120Basal cell carcinoma (HP:0002671)1.77212015
121Cubitus valgus (HP:0002967)1.75908114
122Cerebral hemorrhage (HP:0001342)1.75840102
123Gastrointestinal infarctions (HP:0005244)1.75555459
124Abnormality of proline metabolism (HP:0010907)1.75411616
125Hydroxyprolinuria (HP:0003080)1.75411616
126Optic neuritis (HP:0100653)1.74946574
127Retrobulbar optic neuritis (HP:0100654)1.74946574
128Keratoconjunctivitis sicca (HP:0001097)1.74516370
129Gingivitis (HP:0000230)1.73987600
130Hyperammonemia (HP:0001987)1.73949895
131Orchitis (HP:0100796)1.73414475
132Slow saccadic eye movements (HP:0000514)1.73403097
133Pulmonary infiltrates (HP:0002113)1.72998102
134Fat malabsorption (HP:0002630)1.71885534
135Abnormality of the distal phalanges of the toes (HP:0010182)1.71763458
136Abnormal platelet volume (HP:0011876)1.71709861
137Mitral valve prolapse (HP:0001634)1.71673691
138Interstitial pulmonary disease (HP:0006530)1.71611088
139Absent frontal sinuses (HP:0002688)1.71306106
140Subacute progressive viral hepatitis (HP:0006572)1.71079341
141Urticaria (HP:0001025)1.70964319
142Periodontitis (HP:0000704)1.70779109
143Gastrointestinal stroma tumor (HP:0100723)1.69702507
144Frequent falls (HP:0002359)1.69623117
145Gastrointestinal inflammation (HP:0004386)1.69308114
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68638786
147Meningitis (HP:0001287)1.67671895
148Vertebral arch anomaly (HP:0008438)1.67527194
149Neonatal onset (HP:0003623)1.67485874
150Coarse hair (HP:0002208)1.66986769
151Septate vagina (HP:0001153)1.66841337
152Hemiplegia (HP:0002301)1.66652312
153Long eyelashes (HP:0000527)1.66097306
154Hypoplasia of the thymus (HP:0000778)1.65895410
155T lymphocytopenia (HP:0005403)1.65862949
156Thick nail (HP:0001805)1.65431580
157Abnormality of the salivary glands (HP:0010286)1.64088153
158Ridged nail (HP:0001807)1.64026981
159Sandal gap (HP:0001852)1.62206947
160Short nail (HP:0001799)1.60523732
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59553304
162Panhypogammaglobulinemia (HP:0003139)1.58993681
163Transitional cell carcinoma of the bladder (HP:0006740)1.58445016
164Abnormal foot bone ossification (HP:0010675)1.58063496
165Abnormality of the columella (HP:0009929)1.57870091
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.57329167
167Segmental peripheral demyelination/remyelination (HP:0003481)1.57243781
168Chest pain (HP:0100749)1.56684044
169Bladder carcinoma (HP:0002862)1.56308860
170Bladder neoplasm (HP:0009725)1.56308860
171Deviation of the thumb (HP:0009603)1.54011564
172Ulnar bowing (HP:0003031)1.54010284
173Renal cell carcinoma (HP:0005584)1.53319742
174Leiomyosarcoma (HP:0100243)1.52439474
175Uterine leiomyosarcoma (HP:0002891)1.52439474
176Abnormality of chromosome segregation (HP:0002916)1.51569976
177Disproportionate tall stature (HP:0001519)1.50743104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.43790145
2CDK123.49080051
3TRIB32.90158095
4SMG12.87305658
5MAP3K142.74956610
6RIPK42.52859759
7MAP4K12.44345527
8MAP3K132.23442647
9ICK2.05996725
10FGFR42.05434708
11JAK12.03532054
12PKN22.03252189
13FRK2.02213362
14JAK31.96683222
15TYK21.94073123
16FGFR31.91174615
17SIK11.78127308
18RIPK11.67898350
19MAP3K71.56676899
20FGFR21.52762523
21TXK1.51862247
22TBK11.51822709
23GRK61.48651847
24IRAK21.47963494
25SYK1.45359293
26MAP2K41.44900482
27BRD41.43361767
28CSF1R1.41439081
29JAK21.39556732
30FLT31.37649206
31ERN11.37381318
32SIK21.36955812
33TTN1.36808764
34CDK61.35981999
35CAMKK11.35941604
36ZAP701.35878193
37DAPK21.34745477
38MAP2K31.33767194
39EPHA41.30909160
40IRAK31.27302815
41PDK11.19357172
42PDGFRA1.16909533
43RET1.16653251
44SIK31.14053199
45TNK21.13421615
46FES1.13120036
47TAOK31.11647168
48IKBKE1.09656184
49SCYL21.08750922
50IRAK41.07918298
51RPS6KB21.04607980
52NTRK31.04489730
53CDK91.02108009
54MAP3K101.01441580
55MARK21.01089917
56ITK1.01042132
57IKBKB1.00989256
58TGFBR21.00584613
59MTOR1.00418220
60KIT0.99521666
61INSRR0.99254004
62SGK30.97091027
63PTK60.94551400
64DMPK0.90981665
65CAMK1D0.89337261
66PRKCQ0.89242414
67LRRK20.84585420
68YES10.83883746
69EPHA20.83148013
70PRKAA20.82783614
71MAPK110.80707536
72BMPR20.79461105
73TAOK10.79222308
74PDPK10.78785777
75LCK0.78508691
76MAPK120.78332500
77PRKCH0.78083884
78TAOK20.77741451
79MST1R0.76566784
80CAMK1G0.76513073
81PINK10.75307902
82EEF2K0.74594291
83CHUK0.74274135
84CSK0.74044205
85HCK0.73539366
86BTK0.73462066
87MAP3K20.71679675
88BCKDK0.70894816
89TRPM70.68798468
90EPHB10.68526267
91CDC42BPA0.68023354
92MAP3K30.67806133
93BMX0.67753663
94PIK3CG0.67670013
95CDK70.67647015
96HIPK20.67087581
97STK110.66408466
98CAMKK20.66162935
99SGK10.65801776
100MELK0.65041525
101MAPK70.64701254
102PIK3CA0.64097090
103BLK0.63091567
104SGK20.62881855
105IRAK10.62003393
106KSR10.61742731
107STK240.61244643
108WNK10.60900436
109PDGFRB0.59185423
110FGR0.55771180
111MAP3K90.54751147
112NEK60.53555934
113NEK90.52035974
114STK380.52019436
115STK100.51790476
116MAP3K80.51776001
117MAP3K60.51501065
118MINK10.50991064
119CDK40.50163842
120TEC0.50078556
121CDK50.47438478
122KSR20.46773401
123MAP2K60.45105891
124MAPK40.44891793
125MAP3K10.44539579
126TYRO30.43744171
127MAP3K50.43465457
128RPS6KA20.42957900
129RPS6KB10.41123752
130MAPK100.40132196
131RPS6KA40.40054204
132RAF10.39422460
133RPS6KC10.37220072
134RPS6KL10.37220072
135MET0.37056636
136MAP2K20.35270611

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.50219974
2Nitrogen metabolism_Homo sapiens_hsa009103.43036520
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.83719377
4Arginine biosynthesis_Homo sapiens_hsa002202.47102947
5Renal cell carcinoma_Homo sapiens_hsa052111.88006256
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86703890
7Endometrial cancer_Homo sapiens_hsa052131.83288055
8Complement and coagulation cascades_Homo sapiens_hsa046101.69250201
9Staphylococcus aureus infection_Homo sapiens_hsa051501.69180605
10Thyroid cancer_Homo sapiens_hsa052161.68871930
11ABC transporters_Homo sapiens_hsa020101.49199393
12Fatty acid degradation_Homo sapiens_hsa000711.49027375
13Tryptophan metabolism_Homo sapiens_hsa003801.46440065
14Prostate cancer_Homo sapiens_hsa052151.43783765
15Colorectal cancer_Homo sapiens_hsa052101.43036800
16ErbB signaling pathway_Homo sapiens_hsa040121.41556323
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39977310
18PPAR signaling pathway_Homo sapiens_hsa033201.39375952
19Notch signaling pathway_Homo sapiens_hsa043301.36969185
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36731053
21B cell receptor signaling pathway_Homo sapiens_hsa046621.33804369
22Bile secretion_Homo sapiens_hsa049761.28851945
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28442230
24Osteoclast differentiation_Homo sapiens_hsa043801.28049603
25Small cell lung cancer_Homo sapiens_hsa052221.23072822
26Leishmaniasis_Homo sapiens_hsa051401.17236890
27Choline metabolism in cancer_Homo sapiens_hsa052311.16915655
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.16907855
29Caffeine metabolism_Homo sapiens_hsa002321.16071339
30* Inositol phosphate metabolism_Homo sapiens_hsa005621.16051890
31Hepatitis C_Homo sapiens_hsa051601.15031444
32MicroRNAs in cancer_Homo sapiens_hsa052061.14857481
33Insulin resistance_Homo sapiens_hsa049311.12349868
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09507132
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07953256
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07754386
37Bladder cancer_Homo sapiens_hsa052191.04047319
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03839503
39Herpes simplex infection_Homo sapiens_hsa051681.03675935
40Viral myocarditis_Homo sapiens_hsa054161.03622850
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03396693
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03361047
43Viral carcinogenesis_Homo sapiens_hsa052031.03170594
44Apoptosis_Homo sapiens_hsa042101.02474172
45Sphingolipid signaling pathway_Homo sapiens_hsa040711.02358213
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.02268495
47T cell receptor signaling pathway_Homo sapiens_hsa046601.01639472
48HTLV-I infection_Homo sapiens_hsa051661.01571459
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01406043
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01054016
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.00242556
52Estrogen signaling pathway_Homo sapiens_hsa049151.00006424
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99772915
54Adherens junction_Homo sapiens_hsa045200.99397488
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.99337695
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99293401
57Graft-versus-host disease_Homo sapiens_hsa053320.98743189
58FoxO signaling pathway_Homo sapiens_hsa040680.98705413
59Fatty acid metabolism_Homo sapiens_hsa012120.95139491
60Proteoglycans in cancer_Homo sapiens_hsa052050.94044726
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92895424
62Peroxisome_Homo sapiens_hsa041460.92726644
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91981584
64Dorso-ventral axis formation_Homo sapiens_hsa043200.89411857
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.88786857
66Propanoate metabolism_Homo sapiens_hsa006400.87521859
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87132887
68Non-small cell lung cancer_Homo sapiens_hsa052230.86741887
69Primary immunodeficiency_Homo sapiens_hsa053400.85834442
70Type II diabetes mellitus_Homo sapiens_hsa049300.83006820
71Focal adhesion_Homo sapiens_hsa045100.82863118
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82027085
73Chemokine signaling pathway_Homo sapiens_hsa040620.81385106
74Starch and sucrose metabolism_Homo sapiens_hsa005000.81360409
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78997647
76Lysine degradation_Homo sapiens_hsa003100.77503964
77Shigellosis_Homo sapiens_hsa051310.77244521
78Toxoplasmosis_Homo sapiens_hsa051450.77188242
79Long-term potentiation_Homo sapiens_hsa047200.75136753
80Epstein-Barr virus infection_Homo sapiens_hsa051690.74780414
81Butanoate metabolism_Homo sapiens_hsa006500.74307472
82Tuberculosis_Homo sapiens_hsa051520.73244168
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72905596
84TNF signaling pathway_Homo sapiens_hsa046680.72329520
85AMPK signaling pathway_Homo sapiens_hsa041520.72325575
86Autoimmune thyroid disease_Homo sapiens_hsa053200.72080039
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72072152
88HIF-1 signaling pathway_Homo sapiens_hsa040660.71890758
89Platelet activation_Homo sapiens_hsa046110.71455372
90Renin secretion_Homo sapiens_hsa049240.71402162
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70765374
92mRNA surveillance pathway_Homo sapiens_hsa030150.70717955
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70563454
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70544135
95beta-Alanine metabolism_Homo sapiens_hsa004100.69631359
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69367519
97Measles_Homo sapiens_hsa051620.68864572
98Amoebiasis_Homo sapiens_hsa051460.68154105
99Pertussis_Homo sapiens_hsa051330.67634978
100Endocytosis_Homo sapiens_hsa041440.67540602
101Phenylalanine metabolism_Homo sapiens_hsa003600.67532908
102Cell cycle_Homo sapiens_hsa041100.67108474
103African trypanosomiasis_Homo sapiens_hsa051430.66795351
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65725132
105Fatty acid biosynthesis_Homo sapiens_hsa000610.65689966
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65060279
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64732861
108Glioma_Homo sapiens_hsa052140.64016700
109VEGF signaling pathway_Homo sapiens_hsa043700.63822572
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.62075497
111* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62048929
112MAPK signaling pathway_Homo sapiens_hsa040100.61813594
113Antigen processing and presentation_Homo sapiens_hsa046120.60997716
114Histidine metabolism_Homo sapiens_hsa003400.59825614
115Pathways in cancer_Homo sapiens_hsa052000.59816473
116Acute myeloid leukemia_Homo sapiens_hsa052210.59305264
117GABAergic synapse_Homo sapiens_hsa047270.58891531
118Glutamatergic synapse_Homo sapiens_hsa047240.57785828
119Circadian entrainment_Homo sapiens_hsa047130.57747836
120Oxytocin signaling pathway_Homo sapiens_hsa049210.57001903
121Cholinergic synapse_Homo sapiens_hsa047250.55435589
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55159642
123Gastric acid secretion_Homo sapiens_hsa049710.54928982
124Pancreatic cancer_Homo sapiens_hsa052120.54040694
125Glycerolipid metabolism_Homo sapiens_hsa005610.53997022
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.53676811
127Melanoma_Homo sapiens_hsa052180.53666180
128Morphine addiction_Homo sapiens_hsa050320.53380820
129Rap1 signaling pathway_Homo sapiens_hsa040150.53343206
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51170807
131Glucagon signaling pathway_Homo sapiens_hsa049220.51025467
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50670111
133Chronic myeloid leukemia_Homo sapiens_hsa052200.50526744
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.49401070
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.49261133
136Olfactory transduction_Homo sapiens_hsa047400.48498215
137mTOR signaling pathway_Homo sapiens_hsa041500.48312585
138Hematopoietic cell lineage_Homo sapiens_hsa046400.48092557
139Fat digestion and absorption_Homo sapiens_hsa049750.48090474
140Chemical carcinogenesis_Homo sapiens_hsa052040.47185506
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46887156
142Prion diseases_Homo sapiens_hsa050200.46619271
143Salivary secretion_Homo sapiens_hsa049700.46420865
144Hepatitis B_Homo sapiens_hsa051610.46010416
145Prolactin signaling pathway_Homo sapiens_hsa049170.44710212
146Influenza A_Homo sapiens_hsa051640.43668025
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43325902
148Insulin signaling pathway_Homo sapiens_hsa049100.42989731
149GnRH signaling pathway_Homo sapiens_hsa049120.42411709
150Allograft rejection_Homo sapiens_hsa053300.42148126
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41480036
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41465832

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