MTHFD2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.27919631
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.01882910
3protein neddylation (GO:0045116)4.58081302
4epithelial cilium movement (GO:0003351)4.49775915
5axonemal dynein complex assembly (GO:0070286)4.39835273
6protein prenylation (GO:0018342)4.26276200
7prenylation (GO:0097354)4.26276200
8polyketide metabolic process (GO:0030638)4.25581950
9doxorubicin metabolic process (GO:0044598)4.25581950
10daunorubicin metabolic process (GO:0044597)4.25581950
11indole-containing compound catabolic process (GO:0042436)3.72061011
12indolalkylamine catabolic process (GO:0046218)3.72061011
13tryptophan catabolic process (GO:0006569)3.72061011
14motile cilium assembly (GO:0044458)3.70743230
15sperm motility (GO:0030317)3.70194024
16mesenchymal cell differentiation involved in renal system development (GO:2001012)3.68436081
17mesenchymal cell differentiation involved in kidney development (GO:0072161)3.68436081
18metanephric mesenchyme development (GO:0072075)3.50110192
19cell differentiation involved in metanephros development (GO:0072202)3.47823917
20facial nerve structural organization (GO:0021612)3.44238880
21cellular biogenic amine catabolic process (GO:0042402)3.41104908
22amine catabolic process (GO:0009310)3.41104908
23indolalkylamine metabolic process (GO:0006586)3.38722910
24protein polyglutamylation (GO:0018095)3.38304823
25L-fucose catabolic process (GO:0042355)3.35305583
26fucose catabolic process (GO:0019317)3.35305583
27L-fucose metabolic process (GO:0042354)3.35305583
28tryptophan metabolic process (GO:0006568)3.34566257
29ventricular system development (GO:0021591)3.34208152
30axoneme assembly (GO:0035082)3.32299947
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30320154
32NADH dehydrogenase complex assembly (GO:0010257)3.23027343
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23027343
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.23027343
35replication fork processing (GO:0031297)3.22326667
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22293169
37negative regulation of translation, ncRNA-mediated (GO:0040033)3.22293169
38regulation of translation, ncRNA-mediated (GO:0045974)3.22293169
39cranial nerve morphogenesis (GO:0021602)3.21408156
40regulation of cilium movement (GO:0003352)3.21239537
41negative regulation of mast cell activation (GO:0033004)3.19035600
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13355895
43kidney mesenchyme development (GO:0072074)3.13176158
44cilium morphogenesis (GO:0060271)3.12982367
45startle response (GO:0001964)3.08319522
46intraciliary transport (GO:0042073)3.03313246
47fusion of sperm to egg plasma membrane (GO:0007342)2.97587744
48urogenital system development (GO:0001655)2.96320898
49postsynaptic membrane organization (GO:0001941)2.95846219
50left/right axis specification (GO:0070986)2.90792681
51cranial nerve structural organization (GO:0021604)2.90754555
52glomerulus development (GO:0032835)2.89858438
53centriole replication (GO:0007099)2.89092624
54regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87842018
55photoreceptor cell maintenance (GO:0045494)2.87723393
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86851121
57pseudouridine synthesis (GO:0001522)2.85886991
58limb bud formation (GO:0060174)2.85619020
59cellular ketone body metabolic process (GO:0046950)2.85219186
60reciprocal meiotic recombination (GO:0007131)2.84921805
61reciprocal DNA recombination (GO:0035825)2.84921805
62double-strand break repair via homologous recombination (GO:0000724)2.84525942
63recombinational repair (GO:0000725)2.84268195
64mitochondrial respiratory chain complex assembly (GO:0033108)2.83607943
65rRNA modification (GO:0000154)2.82903801
66righting reflex (GO:0060013)2.81683930
67microtubule depolymerization (GO:0007019)2.81129866
68kynurenine metabolic process (GO:0070189)2.80838677
69cell differentiation involved in kidney development (GO:0061005)2.80593527
70ribosomal small subunit assembly (GO:0000028)2.80386257
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79903935
72regulation of pigment cell differentiation (GO:0050932)2.79799874
73presynaptic membrane assembly (GO:0097105)2.78234024
74nonmotile primary cilium assembly (GO:0035058)2.77843299
75kidney morphogenesis (GO:0060993)2.77663182
76DNA deamination (GO:0045006)2.77548184
77multicellular organism reproduction (GO:0032504)2.77507357
78intra-S DNA damage checkpoint (GO:0031573)2.75310723
79mesonephros development (GO:0001823)2.74681303
80attachment of spindle microtubules to kinetochore (GO:0008608)2.74597418
81atrial cardiac muscle cell action potential (GO:0086014)2.73581839
82dopamine transport (GO:0015872)2.73289842
83proteasome assembly (GO:0043248)2.72769886
84ganglion development (GO:0061548)2.72605049
85rRNA methylation (GO:0031167)2.72596626
86opioid receptor signaling pathway (GO:0038003)2.72587031
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72416429
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70860317
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70860317
90negative regulation of heart rate (GO:0010459)2.69450151
91resolution of meiotic recombination intermediates (GO:0000712)2.66166227
92cellular component assembly involved in morphogenesis (GO:0010927)2.65596816
93amino acid salvage (GO:0043102)2.64482332
94L-methionine salvage (GO:0071267)2.64482332
95L-methionine biosynthetic process (GO:0071265)2.64482332
96rhodopsin mediated signaling pathway (GO:0016056)2.64029086
97inner ear receptor stereocilium organization (GO:0060122)2.63888470
98tRNA methylation (GO:0030488)2.63793330
99regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63662125
100response to pheromone (GO:0019236)2.63238475
101superoxide anion generation (GO:0042554)2.62489224
102dentate gyrus development (GO:0021542)2.62461206
103detection of light stimulus involved in sensory perception (GO:0050962)2.62234207
104detection of light stimulus involved in visual perception (GO:0050908)2.62234207
105mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62203484
106adenosine metabolic process (GO:0046085)2.61731975
107negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.61365559
108signal peptide processing (GO:0006465)2.60692996
109reflex (GO:0060004)2.58321406
110establishment of protein localization to Golgi (GO:0072600)2.57973048
111DNA-dependent DNA replication (GO:0006261)2.56995140
112male meiosis (GO:0007140)2.55265954
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54376714
114ketone body metabolic process (GO:1902224)2.54239965
115termination of RNA polymerase III transcription (GO:0006386)2.53184005
116transcription elongation from RNA polymerase III promoter (GO:0006385)2.53184005
117regulation of timing of cell differentiation (GO:0048505)2.52024130
118microtubule anchoring (GO:0034453)2.52001031
119regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.51843039
120negative regulation of DNA-dependent DNA replication (GO:2000104)2.51807360
121centriole assembly (GO:0098534)2.51574627
122GPI anchor metabolic process (GO:0006505)2.50651105
123hindbrain development (GO:0030902)2.49977919
124regulation of development, heterochronic (GO:0040034)2.49400659
125organelle membrane fusion (GO:0090174)2.48771965
126aromatic amino acid family catabolic process (GO:0009074)2.48091104
127water-soluble vitamin biosynthetic process (GO:0042364)2.48075392
128extracellular regulation of signal transduction (GO:1900115)2.45625017
129extracellular negative regulation of signal transduction (GO:1900116)2.45625017
130sympathetic nervous system development (GO:0048485)2.43059168
131positive regulation of synapse assembly (GO:0051965)2.42912244
132positive regulation of protein homodimerization activity (GO:0090073)2.41808206
133cerebral cortex radially oriented cell migration (GO:0021799)2.41111824
134presynaptic membrane organization (GO:0097090)2.41097987
135aminoglycoside antibiotic metabolic process (GO:0030647)2.40351188
136viral protein processing (GO:0019082)2.39612947
137somite development (GO:0061053)2.39045343
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38552239
139GTP biosynthetic process (GO:0006183)2.38401022
140lymphoid progenitor cell differentiation (GO:0002320)2.36731482
141cilium assembly (GO:0042384)2.36433162
142energy homeostasis (GO:0097009)2.35718235
143protein complex biogenesis (GO:0070271)2.33185241
144negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.33083575
145generation of neurons (GO:0048699)2.32628014
146cell proliferation in forebrain (GO:0021846)2.32560955
147neuron cell-cell adhesion (GO:0007158)2.30686546
148histone H3-K4 trimethylation (GO:0080182)2.28909820
149DNA demethylation (GO:0080111)2.28048288
150positive regulation of gastrulation (GO:2000543)2.27375334
151spinal cord association neuron differentiation (GO:0021527)2.27338262
152cilium organization (GO:0044782)2.27309749
153developmental pigmentation (GO:0048066)2.26808200
154DNA dealkylation (GO:0035510)2.25243054
155mesenchymal cell differentiation (GO:0048762)2.25110238
156DNA double-strand break processing (GO:0000729)2.24799299
157negative regulation of axon guidance (GO:1902668)2.23967721
158regulation of synapse assembly (GO:0051963)2.22865733
159regulation of respiratory system process (GO:0044065)2.22732076
160platelet dense granule organization (GO:0060155)2.20901689
161positive regulation of cellular amide metabolic process (GO:0034250)2.20643800
162kinetochore assembly (GO:0051382)2.17520772
163histone H2A acetylation (GO:0043968)2.17289291
164regulation of mesenchymal cell apoptotic process (GO:2001053)2.16936002
165mannosylation (GO:0097502)2.16354446
166replicative senescence (GO:0090399)2.15425397
167pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.15199278
168smooth muscle tissue development (GO:0048745)2.14680470
169neural tube formation (GO:0001841)2.12828832
170axonal fasciculation (GO:0007413)2.12730119
171cilium movement (GO:0003341)2.12661995
172negative regulation of stem cell proliferation (GO:2000647)2.10962820
173neuron recognition (GO:0008038)2.10292153
174definitive hemopoiesis (GO:0060216)2.09760650
175cytochrome complex assembly (GO:0017004)2.09552509
176DNA catabolic process, exonucleolytic (GO:0000738)2.09441129
177specification of organ identity (GO:0010092)2.09236141
178viral mRNA export from host cell nucleus (GO:0046784)2.08450142
179respiratory chain complex IV assembly (GO:0008535)2.07985121
180mesenchymal-epithelial cell signaling (GO:0060638)2.07519732
181deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.07049603
182regulation of mitochondrial translation (GO:0070129)2.06811082
183regulation of mRNA splicing, via spliceosome (GO:0048024)2.06717942
184calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.05724309
185preassembly of GPI anchor in ER membrane (GO:0016254)2.05404783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.40496833
2EZH2_22144423_ChIP-Seq_EOC_Human4.07866893
3GBX2_23144817_ChIP-Seq_PC3_Human3.76321701
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74552401
5ZNF274_21170338_ChIP-Seq_K562_Hela2.74176855
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73078944
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.61833185
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56948983
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48911305
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48713615
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.46763104
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38205107
13IGF1R_20145208_ChIP-Seq_DFB_Human2.34166106
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.25423597
15FUS_26573619_Chip-Seq_HEK293_Human2.22344645
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.21364538
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.15220091
18TAF15_26573619_Chip-Seq_HEK293_Human2.13505174
19EWS_26573619_Chip-Seq_HEK293_Human2.06101140
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05845462
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.00012331
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98655058
23RNF2_27304074_Chip-Seq_NSC_Mouse1.98281701
24* P300_19829295_ChIP-Seq_ESCs_Human1.93742286
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.91126781
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90398742
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.88674608
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87108141
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82671196
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82210108
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81938305
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.79802589
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77693655
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76899898
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76732960
36GATA1_22025678_ChIP-Seq_K562_Human1.70214864
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68533553
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68028743
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64195978
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62419994
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.62112131
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61632622
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61574571
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.61459245
45STAT3_23295773_ChIP-Seq_U87_Human1.60956919
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.60554228
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59542756
48ER_23166858_ChIP-Seq_MCF-7_Human1.56753123
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.55796085
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55345282
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54260838
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53822025
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53474571
54CBP_20019798_ChIP-Seq_JUKART_Human1.53474571
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51262311
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.49814494
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.49496995
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47858332
59VDR_23849224_ChIP-Seq_CD4+_Human1.46856381
60P53_22387025_ChIP-Seq_ESCs_Mouse1.46465343
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45778866
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44327964
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44185801
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42059677
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40802295
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.39903131
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38368082
68TCF4_23295773_ChIP-Seq_U87_Human1.37245569
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.36460390
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.36270442
71TP53_22573176_ChIP-Seq_HFKS_Human1.35316899
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33165781
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32937145
74* NANOG_19829295_ChIP-Seq_ESCs_Human1.32770946
75* SOX2_19829295_ChIP-Seq_ESCs_Human1.32770946
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32506468
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32506468
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31533873
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.30544030
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.30459783
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.29940408
82SMAD4_21799915_ChIP-Seq_A2780_Human1.29887353
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28954764
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.28916507
85* BCAT_22108803_ChIP-Seq_LS180_Human1.27425509
86* TCF4_22108803_ChIP-Seq_LS180_Human1.26652498
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25479080
88P300_18555785_Chip-Seq_ESCs_Mouse1.24768358
89MYC_18940864_ChIP-ChIP_HL60_Human1.24360136
90TP53_18474530_ChIP-ChIP_U2OS_Human1.23617540
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23193299
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.22940591
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22259673
94AR_21572438_ChIP-Seq_LNCaP_Human1.22215312
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.21852555
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21675541
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.20575397
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19175794
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.18903266
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18029773
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17252396
102ELK1_19687146_ChIP-ChIP_HELA_Human1.16728350
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16467705
104VDR_22108803_ChIP-Seq_LS180_Human1.16018345
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15455721
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.14952433
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.14888015
108JUN_21703547_ChIP-Seq_K562_Human1.14653646
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.14531260
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13511283
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11786528
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11786528
113SOX9_26525672_Chip-Seq_HEART_Mouse1.11561244
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11297508
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09892266
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.09892266
117CDX2_22108803_ChIP-Seq_LS180_Human1.09671142
118ZFX_18555785_Chip-Seq_ESCs_Mouse1.08491687
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.07975581
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06962517
121RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06484412
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.05361364
123IRF1_19129219_ChIP-ChIP_H3396_Human1.05206916
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05181884
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05114834
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.04742569
127SOX2_16153702_ChIP-ChIP_HESCs_Human1.04239709
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03230969
129PU1_27457419_Chip-Seq_LIVER_Mouse1.03082517
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01757360
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01331399
132PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00960686
133KLF4_18555785_Chip-Seq_ESCs_Mouse1.00960208
134* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00753013
135* AR_25329375_ChIP-Seq_VCAP_Human0.99134686
136FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98713659
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97898489
138AR_20517297_ChIP-Seq_VCAP_Human0.97820346
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97703812
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97055327
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96600580
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96197417
143SALL4_22934838_ChIP-ChIP_CD34+_Human0.96149955
144CTCF_18555785_Chip-Seq_ESCs_Mouse0.94385663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.78264841
2MP0006292_abnormal_olfactory_placode3.61604359
3MP0002653_abnormal_ependyma_morphology3.16802580
4MP0000566_synostosis3.04677352
5MP0002938_white_spotting2.85325436
6MP0002638_abnormal_pupillary_reflex2.68908530
7MP0005171_absent_coat_pigmentation2.43890628
8MP0003195_calcinosis2.38787939
9MP0002837_dystrophic_cardiac_calcinosis2.38442140
10MP0008877_abnormal_DNA_methylation2.26770871
11MP0006276_abnormal_autonomic_nervous2.19360430
12MP0005645_abnormal_hypothalamus_physiol2.17687515
13MP0005409_darkened_coat_color2.11187832
14MP0003880_abnormal_central_pattern2.09816625
15MP0005410_abnormal_fertilization2.07248085
16MP0008789_abnormal_olfactory_epithelium2.06409862
17MP0003136_yellow_coat_color2.02147325
18MP0003718_maternal_effect2.01154919
19MP0005646_abnormal_pituitary_gland2.00724499
20MP0005253_abnormal_eye_physiology1.99661918
21MP0009379_abnormal_foot_pigmentation1.97030667
22MP0010030_abnormal_orbit_morphology1.96014334
23MP0000383_abnormal_hair_follicle1.88764208
24MP0003122_maternal_imprinting1.88056155
25MP0003941_abnormal_skin_development1.84646136
26MP0004147_increased_porphyrin_level1.84097566
27MP0008995_early_reproductive_senescence1.83403756
28MP0005464_abnormal_platelet_physiology1.82526531
29MP0009046_muscle_twitch1.81654445
30MP0000049_abnormal_middle_ear1.76449478
31MP0002102_abnormal_ear_morphology1.75828817
32MP0005423_abnormal_somatic_nervous1.73762855
33MP0010386_abnormal_urinary_bladder1.72409582
34MP0003787_abnormal_imprinting1.70641467
35MP0005499_abnormal_olfactory_system1.69345484
36MP0005394_taste/olfaction_phenotype1.69345484
37MP0002277_abnormal_respiratory_mucosa1.66702299
38MP0003121_genomic_imprinting1.65690891
39MP0005503_abnormal_tendon_morphology1.65613951
40MP0000678_abnormal_parathyroid_gland1.62913999
41MP0004215_abnormal_myocardial_fiber1.62900053
42MP0008872_abnormal_physiological_respon1.62273964
43MP0002234_abnormal_pharynx_morphology1.56519252
44MP0005174_abnormal_tail_pigmentation1.56109256
45MP0001529_abnormal_vocalization1.56048381
46MP0001986_abnormal_taste_sensitivity1.52857941
47MP0000569_abnormal_digit_pigmentation1.49334319
48MP0004142_abnormal_muscle_tone1.45154772
49MP0009250_abnormal_appendicular_skeleto1.45089514
50MP0000778_abnormal_nervous_system1.42986510
51MP0000026_abnormal_inner_ear1.41875801
52MP0001501_abnormal_sleep_pattern1.41526452
53MP0009697_abnormal_copulation1.39678253
54MP0000631_abnormal_neuroendocrine_gland1.39453364
55MP0000015_abnormal_ear_pigmentation1.39203699
56MP0002249_abnormal_larynx_morphology1.37483296
57MP0002163_abnormal_gland_morphology1.36577120
58MP0003806_abnormal_nucleotide_metabolis1.36552129
59MP0003011_delayed_dark_adaptation1.33629639
60MP0001929_abnormal_gametogenesis1.33252654
61MP0002132_abnormal_respiratory_system1.33207846
62MP0000681_abnormal_thyroid_gland1.32909681
63MP0003698_abnormal_male_reproductive1.30141776
64MP0003938_abnormal_ear_development1.29399031
65MP0001984_abnormal_olfaction1.28865227
66MP0000230_abnormal_systemic_arterial1.28502608
67MP0001346_abnormal_lacrimal_gland1.27188435
68MP0004133_heterotaxia1.26446748
69MP0001502_abnormal_circadian_rhythm1.25126483
70MP0002751_abnormal_autonomic_nervous1.24480439
71MP0000372_irregular_coat_pigmentation1.23734182
72MP0002557_abnormal_social/conspecific_i1.23198860
73MP0002735_abnormal_chemical_nociception1.22809246
74MP0003879_abnormal_hair_cell1.21731949
75MP0002177_abnormal_outer_ear1.20246765
76MP0008058_abnormal_DNA_repair1.19709506
77MP0006035_abnormal_mitochondrial_morpho1.19464209
78MP0002095_abnormal_skin_pigmentation1.18690361
79MP0001486_abnormal_startle_reflex1.18217609
80MP0003942_abnormal_urinary_system1.17327352
81MP0010094_abnormal_chromosome_stability1.16959347
82MP0000427_abnormal_hair_cycle1.16349009
83MP0001764_abnormal_homeostasis1.16140029
84MP0002184_abnormal_innervation1.16110829
85MP0006036_abnormal_mitochondrial_physio1.15181402
86MP0005379_endocrine/exocrine_gland_phen1.14831486
87MP0001968_abnormal_touch/_nociception1.14792420
88MP0004084_abnormal_cardiac_muscle1.14007035
89MP0008875_abnormal_xenobiotic_pharmacok1.11842332
90MP0004742_abnormal_vestibular_system1.11620204
91MP0004043_abnormal_pH_regulation1.10878503
92MP0008007_abnormal_cellular_replicative1.08807051
93MP0003385_abnormal_body_wall1.05493113
94MP0008057_abnormal_DNA_replication1.05481101
95MP0005389_reproductive_system_phenotype1.04741780
96MP0002233_abnormal_nose_morphology1.04247108
97MP0002210_abnormal_sex_determination1.03459434
98MP0003786_premature_aging1.02266846
99MP0005248_abnormal_Harderian_gland1.01345484
100MP0008775_abnormal_heart_ventricle1.00986201
101MP0010678_abnormal_skin_adnexa1.00246004
102MP0003937_abnormal_limbs/digits/tail_de0.99658334
103MP0005167_abnormal_blood-brain_barrier0.98648482
104MP0005187_abnormal_penis_morphology0.98335173
105MP0002272_abnormal_nervous_system0.97491729
106MP0002736_abnormal_nociception_after0.96927065
107MP0001286_abnormal_eye_development0.96701082
108MP0002733_abnormal_thermal_nociception0.96279193
109MP0001186_pigmentation_phenotype0.95647252
110MP0001963_abnormal_hearing_physiology0.95026016
111MP0001919_abnormal_reproductive_system0.94781441
112MP0003755_abnormal_palate_morphology0.94632539
113MP0001970_abnormal_pain_threshold0.92029803
114MP0005075_abnormal_melanosome_morpholog0.91946188
115MP0002116_abnormal_craniofacial_bone0.90984054
116MP0002876_abnormal_thyroid_physiology0.90545640
117MP0005266_abnormal_metabolism0.89884123
118MP0000653_abnormal_sex_gland0.89361499
119MP0003890_abnormal_embryonic-extraembry0.88575876
120MP0000647_abnormal_sebaceous_gland0.87281879
121MP0001485_abnormal_pinna_reflex0.87121085
122MP0002752_abnormal_somatic_nervous0.86371667
123MP0003186_abnormal_redox_activity0.85658488
124MP0002067_abnormal_sensory_capabilities0.83695376
125MP0003646_muscle_fatigue0.81824060
126MP0001905_abnormal_dopamine_level0.81629097
127MP0001270_distended_abdomen0.81509251
128MP0000358_abnormal_cell_content/0.81199669
129MP0005085_abnormal_gallbladder_physiolo0.81116896
130MP0002928_abnormal_bile_duct0.81017288
131MP0001145_abnormal_male_reproductive0.79550942
132MP0001293_anophthalmia0.78707999
133MP0009745_abnormal_behavioral_response0.78542592
134MP0002734_abnormal_mechanical_nocicepti0.78321053
135MP0002282_abnormal_trachea_morphology0.77382808
136MP0005195_abnormal_posterior_eye0.77316871
137MP0002109_abnormal_limb_morphology0.77300777
138MP0005551_abnormal_eye_electrophysiolog0.76830513
139MP0005391_vision/eye_phenotype0.76355633
140MP0002572_abnormal_emotion/affect_behav0.76179452
141MP0004134_abnormal_chest_morphology0.75898241
142MP0002932_abnormal_joint_morphology0.75381307
143MP0000537_abnormal_urethra_morphology0.74830756
144MP0005332_abnormal_amino_acid0.74495518
145MP0004085_abnormal_heartbeat0.73728721
146MP0003252_abnormal_bile_duct0.73628486
147MP0005670_abnormal_white_adipose0.73564545
148MP0005084_abnormal_gallbladder_morpholo0.72212417
149MP0002160_abnormal_reproductive_system0.69862850
150MP0003935_abnormal_craniofacial_develop0.68879685
151MP0000613_abnormal_salivary_gland0.66913199
152MP0002075_abnormal_coat/hair_pigmentati0.66158752
153MP0005508_abnormal_skeleton_morphology0.65401128
154MP0000538_abnormal_urinary_bladder0.64976496
155MP0006072_abnormal_retinal_apoptosis0.64972238
156MP0003878_abnormal_ear_physiology0.64875942
157MP0005377_hearing/vestibular/ear_phenot0.64875942
158MP0002148_abnormal_hypersensitivity_rea0.64407455

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal cortex (HP:0011035)3.74170506
2True hermaphroditism (HP:0010459)3.62114365
3Pancreatic fibrosis (HP:0100732)3.61028732
4Rhinitis (HP:0012384)3.47389393
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28082174
6Tubular atrophy (HP:0000092)3.23585373
7Hypothermia (HP:0002045)3.20984924
8Bile duct proliferation (HP:0001408)3.11847076
9Abnormal biliary tract physiology (HP:0012439)3.11847076
10Chromsome breakage (HP:0040012)2.90624963
11Abnormal hair whorl (HP:0010721)2.84611236
12Acute encephalopathy (HP:0006846)2.83785513
13Congenital stationary night blindness (HP:0007642)2.82794048
14Protruding tongue (HP:0010808)2.81715965
15Attenuation of retinal blood vessels (HP:0007843)2.79832924
16Polydipsia (HP:0001959)2.78086004
17Abnormal drinking behavior (HP:0030082)2.78086004
18Acute necrotizing encephalopathy (HP:0006965)2.76598959
19Abnormality of alanine metabolism (HP:0010916)2.68895414
20Hyperalaninemia (HP:0003348)2.68895414
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68895414
22Chronic hepatic failure (HP:0100626)2.67333209
23Pancreatic cysts (HP:0001737)2.59730627
24Preaxial hand polydactyly (HP:0001177)2.59713657
25Mitochondrial inheritance (HP:0001427)2.57422191
26Type II lissencephaly (HP:0007260)2.57045853
27Medial flaring of the eyebrow (HP:0010747)2.56986700
28Abnormality of the renal collecting system (HP:0004742)2.55966422
29Median cleft lip (HP:0000161)2.55700367
30Progressive macrocephaly (HP:0004481)2.51914622
31Abnormality of midbrain morphology (HP:0002418)2.48668170
32Molar tooth sign on MRI (HP:0002419)2.48668170
33Renal cortical cysts (HP:0000803)2.44248639
34Chronic bronchitis (HP:0004469)2.44078988
35Increased CSF lactate (HP:0002490)2.42177817
36Nephrogenic diabetes insipidus (HP:0009806)2.41596381
37Furrowed tongue (HP:0000221)2.39623924
38Abnormal ciliary motility (HP:0012262)2.39476646
39Abnormal rod and cone electroretinograms (HP:0008323)2.35399557
40Postaxial foot polydactyly (HP:0001830)2.34486193
41Optic nerve coloboma (HP:0000588)2.32196986
42Duplicated collecting system (HP:0000081)2.31118224
43Genetic anticipation (HP:0003743)2.30797345
44Abnormal mitochondria in muscle tissue (HP:0008316)2.28469474
45Congenital sensorineural hearing impairment (HP:0008527)2.27913451
46Hepatic necrosis (HP:0002605)2.27151210
47Type I transferrin isoform profile (HP:0003642)2.26737122
48Decreased central vision (HP:0007663)2.26555769
49Hypoplasia of the pons (HP:0012110)2.26269934
50Facial cleft (HP:0002006)2.25302869
51Septo-optic dysplasia (HP:0100842)2.24964647
52Prolonged bleeding time (HP:0003010)2.24297499
53Febrile seizures (HP:0002373)2.24206135
54Abolished electroretinogram (ERG) (HP:0000550)2.24006161
55Osteomalacia (HP:0002749)2.23760115
56Recurrent sinusitis (HP:0011108)2.23039404
57Abnormality of incisor morphology (HP:0011063)2.22813172
58Reticulocytopenia (HP:0001896)2.22700064
59Abnormality of the pons (HP:0007361)2.22007480
60Optic nerve hypoplasia (HP:0000609)2.21902571
61Severe visual impairment (HP:0001141)2.19962164
62Hepatocellular necrosis (HP:0001404)2.19125629
63Anencephaly (HP:0002323)2.18923973
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.17303373
65Gait imbalance (HP:0002141)2.16323787
66Abnormality of secondary sexual hair (HP:0009888)2.13354861
67Abnormality of the axillary hair (HP:0100134)2.13354861
68Abnormal respiratory motile cilium morphology (HP:0005938)2.10998552
69Abnormal respiratory epithelium morphology (HP:0012253)2.10998552
70Patchy hypopigmentation of hair (HP:0011365)2.10405338
71Congenital primary aphakia (HP:0007707)2.09881847
72Polyuria (HP:0000103)2.09174148
73Supernumerary spleens (HP:0009799)2.08757374
74Nephronophthisis (HP:0000090)2.08370483
75Hyperglycinemia (HP:0002154)2.08364997
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.08310591
77Dyschromatopsia (HP:0007641)2.06727654
78Absent eyebrow (HP:0002223)2.06681664
79White forelock (HP:0002211)2.06370087
80Meckel diverticulum (HP:0002245)2.04889913
81Bronchiectasis (HP:0002110)2.04429526
82Occipital encephalocele (HP:0002085)2.03860362
83Large for gestational age (HP:0001520)2.03224454
84Abnormal respiratory motile cilium physiology (HP:0012261)2.01130148
85Renal Fanconi syndrome (HP:0001994)2.00581049
86Abnormality of the parietal bone (HP:0002696)2.00218628
87Morphological abnormality of the middle ear (HP:0008609)1.99410143
88Congenital, generalized hypertrichosis (HP:0004540)1.97858778
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.97841580
90Absent/shortened dynein arms (HP:0200106)1.97841580
91Increased hepatocellular lipid droplets (HP:0006565)1.97022477
92Sclerocornea (HP:0000647)1.94953202
93Abnormality of the columella (HP:0009929)1.94868510
94Abnormality of the ileum (HP:0001549)1.93474118
95Progressive cerebellar ataxia (HP:0002073)1.93113829
96Cerebellar dysplasia (HP:0007033)1.92603655
97Cutaneous finger syndactyly (HP:0010554)1.92216886
98Duplication of thumb phalanx (HP:0009942)1.91656019
99Aplasia/Hypoplasia of the lens (HP:0008063)1.91071243
100Gaze-evoked nystagmus (HP:0000640)1.90985139
101Oculomotor apraxia (HP:0000657)1.90848065
102Lipid accumulation in hepatocytes (HP:0006561)1.89137189
103Abnormality of the nasolacrimal system (HP:0000614)1.89013223
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87647090
105Hyperventilation (HP:0002883)1.87103552
106Congenital hepatic fibrosis (HP:0002612)1.86827933
107Abnormality of the carotid arteries (HP:0005344)1.86236683
108Ectopic kidney (HP:0000086)1.85833204
109Cutaneous syndactyly (HP:0012725)1.85713763
110Abnormality of the nasal septum (HP:0000419)1.85338607
111Tubulointerstitial nephritis (HP:0001970)1.84506396
112Genital tract atresia (HP:0001827)1.82403914
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.80738198
114Aganglionic megacolon (HP:0002251)1.79238240
115Male pseudohermaphroditism (HP:0000037)1.79143730
116Increased serum lactate (HP:0002151)1.78580951
117Abnormality of the preputium (HP:0100587)1.77422799
118Postaxial hand polydactyly (HP:0001162)1.77253349
119Increased number of teeth (HP:0011069)1.76865158
120Abnormality of the lacrimal duct (HP:0011481)1.76433535
121Intestinal atresia (HP:0011100)1.75628541
122Retinal dysplasia (HP:0007973)1.74090967
123Abnormality of the phalanges of the hallux (HP:0010057)1.73797591
124Heterochromia iridis (HP:0001100)1.73788702
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73673655
1263-Methylglutaconic aciduria (HP:0003535)1.73303179
127Short middle phalanx of the 5th finger (HP:0004220)1.72757802
128Renal duplication (HP:0000075)1.72436404
129Prominent nasal bridge (HP:0000426)1.72380358
130Cerebral edema (HP:0002181)1.71919771
131Abnormality of the renal medulla (HP:0100957)1.71827157
132Lactic acidosis (HP:0003128)1.71563011
133Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71176483
134Volvulus (HP:0002580)1.70589092
135Cystic liver disease (HP:0006706)1.70402500
136Renal dysplasia (HP:0000110)1.69965848
137Fair hair (HP:0002286)1.69956351
138Bony spicule pigmentary retinopathy (HP:0007737)1.69105787
139Vaginal atresia (HP:0000148)1.69069624
140Abnormal urine output (HP:0012590)1.68831127
141Central scotoma (HP:0000603)1.68660046
142Hyperglycinuria (HP:0003108)1.68480228
143Abnormality of macular pigmentation (HP:0008002)1.67679627
144Aplasia cutis congenita (HP:0001057)1.67503538
145Abnormality of the incisor (HP:0000676)1.67030473
146Poor coordination (HP:0002370)1.66642452
147Nephroblastoma (Wilms tumor) (HP:0002667)1.66375569
148Colon cancer (HP:0003003)1.65350727
149Anophthalmia (HP:0000528)1.65344707
150Nasolacrimal duct obstruction (HP:0000579)1.65342555
151Thyroid-stimulating hormone excess (HP:0002925)1.63333289
152Clubbing of toes (HP:0100760)1.63133161
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62907875
154Elfin facies (HP:0004428)1.61815569
155Lissencephaly (HP:0001339)1.61722021
156Triphalangeal thumb (HP:0001199)1.60609114
157Abnormal number of incisors (HP:0011064)1.60187459
158Abnormality of the phalanges of the 5th finger (HP:0004213)1.59364112
159Embryonal renal neoplasm (HP:0011794)1.58798130
160Absent hair (HP:0002298)1.57762683
161Abnormality of the right ventricle (HP:0001707)1.57621591
162Abnormality of the septum pellucidum (HP:0007375)1.57416458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.97016875
2CASK4.19407767
3TNIK3.96096725
4ZAK3.42877862
5MAP4K23.03323504
6ERBB32.82471936
7VRK12.65135428
8SIK32.57419397
9SRPK12.34828725
10BMPR1B2.30297960
11MST42.20191652
12MAPK132.19819655
13TAOK32.13995989
14MKNK12.12964090
15IRAK42.02422231
16INSRR1.94611521
17IRAK31.93988830
18BRD41.93651649
19STK161.82096608
20MARK11.80461688
21EIF2AK21.79361844
22YES11.73667054
23MAP3K121.69166947
24ADRBK21.67773999
25MAP3K41.63211158
26TRIM281.60380309
27MAP2K71.58476644
28PNCK1.53607063
29MKNK21.50854546
30NTRK21.49775380
31TXK1.44118262
32PTK2B1.40180623
33NEK11.39521250
34PINK11.35883850
35CDK31.34295384
36BMPR21.33419889
37STK31.31455650
38BRSK21.31312275
39VRK21.29220298
40SGK21.28308324
41CDK81.24159973
42AKT31.23983695
43MAP3K141.21713637
44BCKDK1.15388730
45LIMK11.11056762
46IRAK21.09616146
47NTRK31.07644776
48DYRK21.06775144
49DYRK31.05754640
50TEC1.04342491
51PRPF4B1.03604806
52IRAK11.02135070
53STK390.96000846
54PLK30.93689350
55TIE10.93591074
56GRK10.93535039
57GRK70.91883954
58EIF2AK10.90727898
59EPHA30.90070186
60ATR0.88769538
61MAPK150.88254303
62TNK20.87909505
63MUSK0.87436364
64CCNB10.87051920
65BCR0.84951777
66CSNK1G10.84902478
67EIF2AK30.82352322
68WNK40.82052061
69PLK40.81679761
70TLK10.79738760
71TGFBR10.78509826
72CSNK1G30.76865243
73OXSR10.76078546
74SIK20.74069785
75TAOK20.73206589
76CSNK1G20.72334746
77WNK30.70865137
78PASK0.70563766
79NEK60.69662994
80SGK4940.68467556
81SGK2230.68467556
82ADRBK10.66750313
83PRKCE0.66529163
84CDC42BPA0.66057676
85RPS6KB10.65486939
86PIK3CG0.65243052
87STK38L0.64779729
88ACVR1B0.64099186
89NME10.63268916
90PIM20.61379427
91WEE10.61219138
92CAMKK20.60431548
93PLK20.60303496
94CHUK0.60062863
95BMX0.59374201
96CHEK20.52510029
97GRK50.52066838
98TSSK60.51482192
99DYRK1A0.51318271
100DAPK20.51108427
101OBSCN0.50733838
102STK240.48794861
103NUAK10.48395420
104CDC70.48289346
105KIT0.47148949
106CLK10.46919508
107FER0.45055957
108EPHB20.44181060
109ATM0.43625832
110ROCK10.41662842
111CDK190.41355509
112NLK0.40945484
113MAP3K50.40343917
114PRKCG0.39659536
115PLK10.39560812
116PAK30.39509434
117MAPKAPK50.39103554
118RPS6KA50.38841746
119UHMK10.38287070
120TAOK10.36642205
121IKBKB0.36468811
122PKN10.36461764
123CAMK40.36326559
124BTK0.35908726
125CSF1R0.35451743
126LATS10.34970541
127FLT30.34245577
128CAMK2A0.33644616
129CSNK1A1L0.32288096
130SGK30.31855827
131TAF10.31599339
132PBK0.31173742
133PRKCQ0.30820055
134CAMK10.30655612
135PHKG20.30250281
136PHKG10.30250281
137LYN0.29734270
138PIK3CA0.29709482
139SYK0.29492090
140PRKACA0.28932161
141CSNK2A10.28218055
142MYLK0.28033067
143AKT10.28019839
144PRKG10.27525006
145NEK90.25280928
146CAMK2B0.25119641
147SGK10.24454868

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.47634349
2Fanconi anemia pathway_Homo sapiens_hsa034602.34049317
3Butanoate metabolism_Homo sapiens_hsa006502.25208500
4Nitrogen metabolism_Homo sapiens_hsa009102.14240744
5Nicotine addiction_Homo sapiens_hsa050332.11307777
6Protein export_Homo sapiens_hsa030602.08722307
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03460587
8Propanoate metabolism_Homo sapiens_hsa006402.01122811
9Homologous recombination_Homo sapiens_hsa034401.95295214
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87932567
11Selenocompound metabolism_Homo sapiens_hsa004501.84407351
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.81990429
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81898373
14Linoleic acid metabolism_Homo sapiens_hsa005911.76921066
15RNA polymerase_Homo sapiens_hsa030201.74803048
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72909742
17Tryptophan metabolism_Homo sapiens_hsa003801.66592562
18Basal transcription factors_Homo sapiens_hsa030221.65560800
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65499079
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63948378
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63216471
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63044493
23Sulfur metabolism_Homo sapiens_hsa009201.61304504
24Spliceosome_Homo sapiens_hsa030401.61274267
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52001848
26Serotonergic synapse_Homo sapiens_hsa047261.47804185
27Pyrimidine metabolism_Homo sapiens_hsa002401.46217112
28Caffeine metabolism_Homo sapiens_hsa002321.45375178
29Non-homologous end-joining_Homo sapiens_hsa034501.44866893
30DNA replication_Homo sapiens_hsa030301.42241639
31Peroxisome_Homo sapiens_hsa041461.38336477
32Mismatch repair_Homo sapiens_hsa034301.35565633
33Base excision repair_Homo sapiens_hsa034101.35227549
34Taste transduction_Homo sapiens_hsa047421.33571152
35Oxidative phosphorylation_Homo sapiens_hsa001901.32902972
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30890937
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30735714
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.29843766
39Huntingtons disease_Homo sapiens_hsa050161.27819307
40Nucleotide excision repair_Homo sapiens_hsa034201.21429167
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18689962
42Ether lipid metabolism_Homo sapiens_hsa005651.16907055
43Parkinsons disease_Homo sapiens_hsa050121.13599339
44Morphine addiction_Homo sapiens_hsa050321.12455746
45RNA degradation_Homo sapiens_hsa030181.12053801
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11014860
47* One carbon pool by folate_Homo sapiens_hsa006701.10936999
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.10655179
49Axon guidance_Homo sapiens_hsa043601.10267407
50Purine metabolism_Homo sapiens_hsa002301.09815097
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09170924
52Systemic lupus erythematosus_Homo sapiens_hsa053221.09076625
53Alcoholism_Homo sapiens_hsa050341.07978866
54Chemical carcinogenesis_Homo sapiens_hsa052041.05146637
55ABC transporters_Homo sapiens_hsa020101.04372187
56Autoimmune thyroid disease_Homo sapiens_hsa053201.03425485
57Arachidonic acid metabolism_Homo sapiens_hsa005901.01016379
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00558543
59Basal cell carcinoma_Homo sapiens_hsa052170.98917607
60Phototransduction_Homo sapiens_hsa047440.98864977
61Steroid biosynthesis_Homo sapiens_hsa001000.97755677
62Allograft rejection_Homo sapiens_hsa053300.97638283
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94270594
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93565279
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91973860
66Retinol metabolism_Homo sapiens_hsa008300.89167935
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88384606
68Cell cycle_Homo sapiens_hsa041100.87522143
69mRNA surveillance pathway_Homo sapiens_hsa030150.87221496
70Sphingolipid metabolism_Homo sapiens_hsa006000.86738991
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86443139
72Proteasome_Homo sapiens_hsa030500.86349865
73Fatty acid elongation_Homo sapiens_hsa000620.86119963
74Herpes simplex infection_Homo sapiens_hsa051680.85647451
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85499200
76beta-Alanine metabolism_Homo sapiens_hsa004100.85290618
77Alzheimers disease_Homo sapiens_hsa050100.84421697
78Asthma_Homo sapiens_hsa053100.82188745
79Glycerolipid metabolism_Homo sapiens_hsa005610.81645206
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.81541043
81Type I diabetes mellitus_Homo sapiens_hsa049400.81017143
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80628649
83p53 signaling pathway_Homo sapiens_hsa041150.79964918
84RNA transport_Homo sapiens_hsa030130.79934555
85Cardiac muscle contraction_Homo sapiens_hsa042600.79266459
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78457702
87Graft-versus-host disease_Homo sapiens_hsa053320.77796852
88* Metabolic pathways_Homo sapiens_hsa011000.77542850
89Wnt signaling pathway_Homo sapiens_hsa043100.76986191
90Measles_Homo sapiens_hsa051620.75958678
91N-Glycan biosynthesis_Homo sapiens_hsa005100.75704372
92Rheumatoid arthritis_Homo sapiens_hsa053230.75369703
93Melanoma_Homo sapiens_hsa052180.73777455
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72148416
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.71986101
96Circadian entrainment_Homo sapiens_hsa047130.70853729
97Platelet activation_Homo sapiens_hsa046110.70633628
98Hedgehog signaling pathway_Homo sapiens_hsa043400.70182143
99Glutamatergic synapse_Homo sapiens_hsa047240.70157205
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69501116
101Glutathione metabolism_Homo sapiens_hsa004800.68869802
102Olfactory transduction_Homo sapiens_hsa047400.68185048
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.67968660
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66924768
105Hematopoietic cell lineage_Homo sapiens_hsa046400.65987097
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65759161
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64814791
108Circadian rhythm_Homo sapiens_hsa047100.64543485
109Insulin secretion_Homo sapiens_hsa049110.63843443
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62911613
111Fatty acid biosynthesis_Homo sapiens_hsa000610.61146791
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60573924
113GABAergic synapse_Homo sapiens_hsa047270.60404928
114Dorso-ventral axis formation_Homo sapiens_hsa043200.60171241
115Salivary secretion_Homo sapiens_hsa049700.58641046
116Cocaine addiction_Homo sapiens_hsa050300.58405540
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57654644
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53844360
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52906957
120Phagosome_Homo sapiens_hsa041450.52669406
121Notch signaling pathway_Homo sapiens_hsa043300.52566476
122Collecting duct acid secretion_Homo sapiens_hsa049660.52221940
123Prostate cancer_Homo sapiens_hsa052150.51425207
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50599294
125Fatty acid degradation_Homo sapiens_hsa000710.49269336
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48984351
127Fatty acid metabolism_Homo sapiens_hsa012120.48846673
128Cholinergic synapse_Homo sapiens_hsa047250.48219921
129Long-term depression_Homo sapiens_hsa047300.48000471
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47017770
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46837327
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46242408
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45058985
134Calcium signaling pathway_Homo sapiens_hsa040200.44252520
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44204542
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43608106
137Ras signaling pathway_Homo sapiens_hsa040140.43402900
138Influenza A_Homo sapiens_hsa051640.43298156
139Epstein-Barr virus infection_Homo sapiens_hsa051690.43073363
140Ovarian steroidogenesis_Homo sapiens_hsa049130.42755688
141Dopaminergic synapse_Homo sapiens_hsa047280.42322953
142Melanogenesis_Homo sapiens_hsa049160.41954653
143TNF signaling pathway_Homo sapiens_hsa046680.41926001
144Primary immunodeficiency_Homo sapiens_hsa053400.41664786
145Amphetamine addiction_Homo sapiens_hsa050310.41331506
146Regulation of autophagy_Homo sapiens_hsa041400.40354654
147MicroRNAs in cancer_Homo sapiens_hsa052060.40199934
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.38549986
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36221293
150Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35074348

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »