MTHFD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.53143905
2L-serine metabolic process (GO:0006563)4.52417316
3protein localization to kinetochore (GO:0034501)4.22441218
4mitotic sister chromatid cohesion (GO:0007064)4.03922974
5mitotic metaphase plate congression (GO:0007080)4.02940347
6mitotic nuclear envelope disassembly (GO:0007077)3.90764727
7purine nucleobase biosynthetic process (GO:0009113)3.86847638
8DNA strand elongation involved in DNA replication (GO:0006271)3.84837161
9protein complex localization (GO:0031503)3.71098324
10nuclear pore organization (GO:0006999)3.70839259
11DNA replication initiation (GO:0006270)3.70530606
12DNA strand elongation (GO:0022616)3.65958692
13nuclear envelope disassembly (GO:0051081)3.64940986
14membrane disassembly (GO:0030397)3.64940986
15cellular protein complex localization (GO:0034629)3.64735648
16telomere maintenance via semi-conservative replication (GO:0032201)3.59805257
17DNA unwinding involved in DNA replication (GO:0006268)3.59394438
18formation of translation preinitiation complex (GO:0001731)3.58458668
19protein localization to chromosome, centromeric region (GO:0071459)3.55703199
20nuclear pore complex assembly (GO:0051292)3.55249681
21DNA replication-dependent nucleosome organization (GO:0034723)3.54957134
22DNA replication-dependent nucleosome assembly (GO:0006335)3.54957134
23DNA replication checkpoint (GO:0000076)3.52892365
24establishment of viral latency (GO:0019043)3.52439247
25non-recombinational repair (GO:0000726)3.51498270
26double-strand break repair via nonhomologous end joining (GO:0006303)3.51498270
27attachment of spindle microtubules to kinetochore (GO:0008608)3.49489496
28* folic acid-containing compound biosynthetic process (GO:0009396)3.48411403
29mitotic sister chromatid segregation (GO:0000070)3.39937175
30telomere maintenance via recombination (GO:0000722)3.39909985
31maturation of SSU-rRNA (GO:0030490)3.36260797
32nucleobase-containing small molecule interconversion (GO:0015949)3.35864305
33metaphase plate congression (GO:0051310)3.35679745
34establishment of chromosome localization (GO:0051303)3.34240691
35mitotic chromosome condensation (GO:0007076)3.33623091
36meiotic chromosome segregation (GO:0045132)3.31340501
37regulation of translational termination (GO:0006449)3.23281015
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23073675
39ribosomal small subunit assembly (GO:0000028)3.22003174
40mitotic recombination (GO:0006312)3.21688282
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.20468966
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20468966
43proteasome assembly (GO:0043248)3.17309416
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14508370
45chromatin remodeling at centromere (GO:0031055)3.13242023
46CENP-A containing nucleosome assembly (GO:0034080)3.11476499
47regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11099653
48regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11099653
49protein K6-linked ubiquitination (GO:0085020)3.08511963
50IMP biosynthetic process (GO:0006188)3.07421676
51sister chromatid segregation (GO:0000819)3.06595281
52regulation of spindle organization (GO:0090224)3.06436434
53serine family amino acid biosynthetic process (GO:0009070)3.04735278
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.03355536
55ribosome assembly (GO:0042255)3.03106571
56regulation of translational elongation (GO:0006448)3.01899083
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.01828954
58isotype switching (GO:0045190)3.01828954
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.01828954
60somatic recombination of immunoglobulin gene segments (GO:0016447)3.01389281
61negative regulation of ligase activity (GO:0051352)3.00713723
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00713723
63mitotic spindle assembly checkpoint (GO:0007094)2.98649646
64regulation of sister chromatid segregation (GO:0033045)2.97734205
65regulation of mitotic sister chromatid separation (GO:0010965)2.97734205
66regulation of mitotic sister chromatid segregation (GO:0033047)2.97734205
67DNA replication-independent nucleosome assembly (GO:0006336)2.97057090
68DNA replication-independent nucleosome organization (GO:0034724)2.97057090
69DNA ligation (GO:0006266)2.96248323
70spindle assembly checkpoint (GO:0071173)2.95228770
71DNA catabolic process, exonucleolytic (GO:0000738)2.93379186
72telomere maintenance via telomere lengthening (GO:0010833)2.91398459
73* tetrahydrofolate metabolic process (GO:0046653)2.90617114
74RNA-dependent DNA replication (GO:0006278)2.89721713
75kinetochore organization (GO:0051383)2.87778354
76ribosomal large subunit biogenesis (GO:0042273)2.87368320
77pore complex assembly (GO:0046931)2.80234203
78ribosome biogenesis (GO:0042254)2.80050479
79chromosome segregation (GO:0007059)2.78234265
80nuclear envelope organization (GO:0006998)2.77352853
81nucleobase biosynthetic process (GO:0046112)2.72877704
82ribonucleoprotein complex biogenesis (GO:0022613)2.72745823
83regulation of centrosome cycle (GO:0046605)2.72320539
84regulation of mitotic spindle organization (GO:0060236)2.72151343
85translational initiation (GO:0006413)2.71497475
86IMP metabolic process (GO:0046040)2.70236634
87maturation of 5.8S rRNA (GO:0000460)2.69578635
88translational termination (GO:0006415)2.67522481
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67470389
90regulation of double-strand break repair via homologous recombination (GO:0010569)2.66416371
91viral transcription (GO:0019083)2.65336115
92protein localization to chromosome (GO:0034502)2.65111146
93regulation of centriole replication (GO:0046599)2.65036290
94histone exchange (GO:0043486)2.61963919
95chromatin assembly or disassembly (GO:0006333)2.61862335
96spindle checkpoint (GO:0031577)2.61598391
97ribosomal small subunit biogenesis (GO:0042274)2.59128720
98G1/S transition of mitotic cell cycle (GO:0000082)2.58969850
99cell cycle G1/S phase transition (GO:0044843)2.58969850
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58862835
101tRNA aminoacylation for protein translation (GO:0006418)2.57226927
102heterochromatin organization (GO:0070828)2.56803413
103T cell apoptotic process (GO:0070231)2.56025927
104natural killer cell mediated immunity (GO:0002228)2.55152629
105natural killer cell mediated cytotoxicity (GO:0042267)2.55152629
106regulation of translational fidelity (GO:0006450)2.54425546
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54034815
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53954759
109translational elongation (GO:0006414)2.53333047
110positive regulation of chromosome segregation (GO:0051984)2.52215232
111rRNA processing (GO:0006364)2.52209240
112regulation of chromosome segregation (GO:0051983)2.50945225
113protein targeting to ER (GO:0045047)2.50612374
114cotranslational protein targeting to membrane (GO:0006613)2.49486493
115DNA duplex unwinding (GO:0032508)2.47623164
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47438071
117mitotic cell cycle (GO:0000278)2.47368578
118DNA geometric change (GO:0032392)2.46702702
119tRNA aminoacylation (GO:0043039)2.45792998
120amino acid activation (GO:0043038)2.45792998
121NIK/NF-kappaB signaling (GO:0038061)2.45553816
122negative regulation of chromosome segregation (GO:0051985)2.43978639
123kinetochore assembly (GO:0051382)2.43777638
124mitotic spindle checkpoint (GO:0071174)2.43230342
125transcription-coupled nucleotide-excision repair (GO:0006283)2.43079278
126rRNA metabolic process (GO:0016072)2.42708795
127regulation of protein heterodimerization activity (GO:0043497)2.42585341
128telomere maintenance (GO:0000723)2.42382699
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42182409
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41807935
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41807935
132negative regulation of sister chromatid segregation (GO:0033046)2.41807935
133negative regulation of mitotic sister chromatid separation (GO:2000816)2.41807935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.61990351
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04821349
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.88657753
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45413126
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35887193
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15377212
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.75006067
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73266089
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.71007887
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67070135
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.65643556
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52568970
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48797718
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.39239563
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33547096
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26458222
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25306980
18XRN2_22483619_ChIP-Seq_HELA_Human2.14051203
19VDR_23849224_ChIP-Seq_CD4+_Human2.10464732
20AR_21909140_ChIP-Seq_LNCAP_Human2.08964219
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.06660900
22DCP1A_22483619_ChIP-Seq_HELA_Human2.02590892
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95493477
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88132401
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85795361
26ELK1_19687146_ChIP-ChIP_HELA_Human1.82620846
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82018823
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81791982
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78622834
30MYC_22102868_ChIP-Seq_BL_Human1.72122478
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71815290
32FOXP3_21729870_ChIP-Seq_TREG_Human1.71326207
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71197859
34GABP_19822575_ChIP-Seq_HepG2_Human1.70808413
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70706989
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70438756
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69008860
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.65268989
39* TTF2_22483619_ChIP-Seq_HELA_Human1.63894613
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61591333
41TFEB_21752829_ChIP-Seq_HELA_Human1.58121877
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57166427
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56252581
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54714960
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.53254199
46* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53020623
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52425465
48KDM5A_27292631_Chip-Seq_BREAST_Human1.45408608
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41839232
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41317073
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39459272
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39322723
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39008416
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36764459
55* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34424323
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33930718
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28670557
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27885369
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25905616
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23243116
61CIITA_25753668_ChIP-Seq_RAJI_Human1.21721365
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21309744
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20716517
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20492916
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19220170
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18170780
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17502483
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17169669
69* SPI1_23547873_ChIP-Seq_NB4_Human1.13064623
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.10864160
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10477626
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10297788
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10016158
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.09529347
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.09405433
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07345045
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06574550
78ZNF263_19887448_ChIP-Seq_K562_Human1.06498508
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02594880
80VDR_21846776_ChIP-Seq_THP-1_Human1.02292164
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.02173093
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01817234
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00364448
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.00270930
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.99395011
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98840526
87MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98195639
88* MYB_26560356_Chip-Seq_TH2_Human0.98037200
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97907237
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.97029929
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96140878
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95277336
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95270359
94* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95121844
95MYC_18940864_ChIP-ChIP_HL60_Human0.92411261
96CHD1_26751641_Chip-Seq_LNCaP_Human0.91665070
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90481469
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89751051
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89088026
100MYB_26560356_Chip-Seq_TH1_Human0.89055721
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89023928
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88386599
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87418506
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87233060
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.86789696
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86451582
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85022905
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84425713
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84425713
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84425713
111MAF_26560356_Chip-Seq_TH1_Human0.83993190
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83976531
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83172212
114* ATF3_27146783_Chip-Seq_COLON_Human0.82624848
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82214847
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82120951
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80033234
118* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79873715
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78567661
120ELF5_23300383_ChIP-Seq_T47D_Human0.75334473
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73880669
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72676811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.55387149
2MP0010094_abnormal_chromosome_stability3.60777024
3MP0004957_abnormal_blastocyst_morpholog3.59619571
4MP0003111_abnormal_nucleus_morphology3.39693741
5MP0003077_abnormal_cell_cycle3.39061702
6MP0008057_abnormal_DNA_replication2.92357167
7MP0003941_abnormal_skin_development2.67512781
8MP0008007_abnormal_cellular_replicative2.45658646
9MP0010352_gastrointestinal_tract_polyps2.24642315
10MP0008058_abnormal_DNA_repair2.22011373
11MP0008932_abnormal_embryonic_tissue2.21900053
12MP0010307_abnormal_tumor_latency2.21748772
13MP0001835_abnormal_antigen_presentation2.08195931
14MP0009697_abnormal_copulation2.06585680
15MP0000350_abnormal_cell_proliferation2.03895530
16MP0005076_abnormal_cell_differentiation2.02932491
17MP0002877_abnormal_melanocyte_morpholog1.93759315
18MP0003123_paternal_imprinting1.91945949
19MP0003806_abnormal_nucleotide_metabolis1.87178558
20MP0001730_embryonic_growth_arrest1.82528805
21MP0000685_abnormal_immune_system1.79578103
22MP0002254_reproductive_system_inflammat1.77632515
23MP0009333_abnormal_splenocyte_physiolog1.77492828
24MP0003436_decreased_susceptibility_to1.70642375
25MP0002163_abnormal_gland_morphology1.70042711
26MP0001348_abnormal_lacrimal_gland1.67444015
27MP0004233_abnormal_muscle_weight1.62514647
28MP0000490_abnormal_crypts_of1.57152786
29MP0010234_abnormal_vibrissa_follicle1.57000245
30MP0003763_abnormal_thymus_physiology1.51460458
31MP0009672_abnormal_birth_weight1.48532302
32MP0005671_abnormal_response_to1.47577637
33MP0000858_altered_metastatic_potential1.46743561
34MP0008877_abnormal_DNA_methylation1.44064122
35MP0002019_abnormal_tumor_incidence1.42920882
36MP0002398_abnormal_bone_marrow1.40653424
37MP0003718_maternal_effect1.40557164
38* MP0001697_abnormal_embryo_size1.37515555
39MP0005387_immune_system_phenotype1.35577059
40MP0001790_abnormal_immune_system1.35577059
41MP0001661_extended_life_span1.34326617
42MP0005000_abnormal_immune_tolerance1.34018269
43MP0009785_altered_susceptibility_to1.31455552
44MP0001672_abnormal_embryogenesis/_devel1.30098587
45MP0005380_embryogenesis_phenotype1.30098587
46MP0004185_abnormal_adipocyte_glucose1.27489148
47MP0000313_abnormal_cell_death1.27340489
48MP0006035_abnormal_mitochondrial_morpho1.27132534
49MP0002452_abnormal_antigen_presenting1.26562710
50MP0002405_respiratory_system_inflammati1.24603653
51MP0001800_abnormal_humoral_immune1.24520081
52MP0002396_abnormal_hematopoietic_system1.23922504
53MP0002148_abnormal_hypersensitivity_rea1.23676494
54MP0004808_abnormal_hematopoietic_stem1.22270030
55* MP0002080_prenatal_lethality1.21278645
56MP0003705_abnormal_hypodermis_morpholog1.20092122
57MP0003786_premature_aging1.19954950
58MP0003448_altered_tumor_morphology1.19345436
59MP0003984_embryonic_growth_retardation1.18188378
60MP0002796_impaired_skin_barrier1.17597341
61MP0000703_abnormal_thymus_morphology1.17194189
62MP0005501_abnormal_skin_physiology1.17055713
63MP0003566_abnormal_cell_adhesion1.16745814
64MP0001819_abnormal_immune_cell1.16380963
65MP0002085_abnormal_embryonic_tissue1.15980034
66MP0002420_abnormal_adaptive_immunity1.15327139
67MP0002088_abnormal_embryonic_growth/wei1.14843720
68MP0002722_abnormal_immune_system1.13829662
69MP0002723_abnormal_immune_serum1.12802938
70MP0005451_abnormal_body_composition1.11656853
71MP0004197_abnormal_fetal_growth/weight/1.11628251
72MP0003221_abnormal_cardiomyocyte_apopto1.10772983
73MP0002084_abnormal_developmental_patter1.10599663
74MP0000689_abnormal_spleen_morphology1.10296825
75MP0002009_preneoplasia1.09239491
76MP0000716_abnormal_immune_system1.07725208
77MP0005023_abnormal_wound_healing1.07459055
78MP0002429_abnormal_blood_cell1.06903825
79MP0008438_abnormal_cutaneous_collagen1.01943612
80MP0003186_abnormal_redox_activity1.00840407
81MP0005621_abnormal_cell_physiology1.00499879
82MP0002086_abnormal_extraembryonic_tissu0.97817977
83MP0005310_abnormal_salivary_gland0.96941062
84MP0002060_abnormal_skin_morphology0.96796930
85MP0003303_peritoneal_inflammation0.96117295
86MP0001873_stomach_inflammation0.96040071
87MP0002166_altered_tumor_susceptibility0.96028976
88MP0005025_abnormal_response_to0.94856046
89MP0003937_abnormal_limbs/digits/tail_de0.94137633
90MP0002933_joint_inflammation0.93988672
91MP0002006_tumorigenesis0.91147959
92MP0003890_abnormal_embryonic-extraembry0.90530303
93MP0005408_hypopigmentation0.89413731
94MP0003950_abnormal_plasma_membrane0.89237899
95MP0001915_intracranial_hemorrhage0.88985991
96MP0003656_abnormal_erythrocyte_physiolo0.88684850
97MP0005384_cellular_phenotype0.88333240
98MP0001727_abnormal_embryo_implantation0.87869262
99MP0002653_abnormal_ependyma_morphology0.86913085
100MP0002210_abnormal_sex_determination0.86769910
101MP0010030_abnormal_orbit_morphology0.85328777
102MP0009703_decreased_birth_body0.85275795
103MP0000627_abnormal_mammary_gland0.85196901
104MP0001881_abnormal_mammary_gland0.84810224
105MP0003567_abnormal_fetal_cardiomyocyte0.84785398
106MP0002419_abnormal_innate_immunity0.83020376
107MP0001119_abnormal_female_reproductive0.82327504
108MP0006082_CNS_inflammation0.82027327
109MP0001853_heart_inflammation0.81988266
110MP0000733_abnormal_muscle_development0.81763286
111MP0001216_abnormal_epidermal_layer0.81108759
112MP0002102_abnormal_ear_morphology0.79604742
113MP0000358_abnormal_cell_content/0.78904695
114MP0004264_abnormal_extraembryonic_tissu0.77906692
115MP0001533_abnormal_skeleton_physiology0.77801386
116MP0006054_spinal_hemorrhage0.77453663
117MP0005257_abnormal_intraocular_pressure0.76947653
118MP0001346_abnormal_lacrimal_gland0.75031459
119MP0003121_genomic_imprinting0.74239102
120MP0001145_abnormal_male_reproductive0.73472164
121MP0003315_abnormal_perineum_morphology0.73273352
122MP0003091_abnormal_cell_migration0.72354119
123MP0004510_myositis0.71132449
124MP0001293_anophthalmia0.70810471
125MP0002697_abnormal_eye_size0.69086350
126MP0005390_skeleton_phenotype0.68969874
127MP0001845_abnormal_inflammatory_respons0.68741030
128MP0003453_abnormal_keratinocyte_physiol0.68542080
129MP0002138_abnormal_hepatobiliary_system0.68471674
130MP0002111_abnormal_tail_morphology0.67532255
131MP0001545_abnormal_hematopoietic_system0.67083172
132MP0005397_hematopoietic_system_phenotyp0.67083172
133MP0006036_abnormal_mitochondrial_physio0.66881746
134MP0001929_abnormal_gametogenesis0.64108160
135MP0001243_abnormal_dermal_layer0.62932227
136MP0004782_abnormal_surfactant_physiolog0.62244927
137MP0000537_abnormal_urethra_morphology0.61513289
138MP0001286_abnormal_eye_development0.59939080
139MP0000377_abnormal_hair_follicle0.57792255
140MP0010678_abnormal_skin_adnexa0.54545966
141MP0000653_abnormal_sex_gland0.54377345
142MP0001191_abnormal_skin_condition0.54165603

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.91002204
2Multiple enchondromatosis (HP:0005701)3.78625045
3Irregular epiphyses (HP:0010582)3.63517133
4Degeneration of anterior horn cells (HP:0002398)3.48269164
5Abnormality of the anterior horn cell (HP:0006802)3.48269164
6Microvesicular hepatic steatosis (HP:0001414)3.31106333
7Chromsome breakage (HP:0040012)3.19621593
8Nephroblastoma (Wilms tumor) (HP:0002667)3.19077568
9Carpal bone hypoplasia (HP:0001498)3.17254963
10Embryonal renal neoplasm (HP:0011794)3.02888436
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96035606
12Reticulocytopenia (HP:0001896)2.95383085
13Progressive external ophthalmoplegia (HP:0000590)2.94974868
14Patellar aplasia (HP:0006443)2.85697604
15Breast hypoplasia (HP:0003187)2.84704205
16Increased nuchal translucency (HP:0010880)2.83950262
17Abnormality of glycolysis (HP:0004366)2.77513125
18Flat capital femoral epiphysis (HP:0003370)2.71651229
19Aplasia/Hypoplasia of the patella (HP:0006498)2.64789997
20Small epiphyses (HP:0010585)2.61423647
21Abnormal lung lobation (HP:0002101)2.59702409
22Ependymoma (HP:0002888)2.55439055
23Abnormality of methionine metabolism (HP:0010901)2.54475466
24Squamous cell carcinoma (HP:0002860)2.53527041
25Abnormality of chromosome stability (HP:0003220)2.50361576
26Thrombocytosis (HP:0001894)2.49305632
27Metaphyseal cupping (HP:0003021)2.44524969
28Abnormality of the duodenum (HP:0002246)2.41271912
29Amaurosis fugax (HP:0100576)2.41270624
30Abnormality of the carotid arteries (HP:0005344)2.40423357
31Spastic diplegia (HP:0001264)2.40174672
32Abnormality of the calcaneus (HP:0008364)2.36546722
33Myelodysplasia (HP:0002863)2.35238800
34Short middle phalanx of the 5th finger (HP:0004220)2.34605674
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.33982454
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.33739028
37Absent epiphyses (HP:0010577)2.33739028
38Increased serum pyruvate (HP:0003542)2.33410513
3911 pairs of ribs (HP:0000878)2.32304237
40Selective tooth agenesis (HP:0001592)2.30198341
41Abnormality of the umbilical cord (HP:0010881)2.29920414
42Agnosia (HP:0010524)2.29919467
43Aplastic anemia (HP:0001915)2.27026741
44Progressive muscle weakness (HP:0003323)2.26945108
45Glossoptosis (HP:0000162)2.25506419
46Rough bone trabeculation (HP:0100670)2.24896344
47Neoplasm of the colon (HP:0100273)2.24455600
48Horseshoe kidney (HP:0000085)2.23062405
49Cortical dysplasia (HP:0002539)2.22527205
50Trismus (HP:0000211)2.21535668
51Cervical subluxation (HP:0003308)2.21511640
52Abnormal gallbladder physiology (HP:0012438)2.21310394
53Cholecystitis (HP:0001082)2.21310394
54Meckel diverticulum (HP:0002245)2.20263503
55Spinal muscular atrophy (HP:0007269)2.18206152
56Abnormality of the preputium (HP:0100587)2.16908559
57Deep philtrum (HP:0002002)2.16362832
58Abnormality of T cell number (HP:0011839)2.15866664
59Homocystinuria (HP:0002156)2.14107653
60Abnormality of homocysteine metabolism (HP:0010919)2.14107653
61Ectopic kidney (HP:0000086)2.10526249
62Premature graying of hair (HP:0002216)2.09569404
63IgA deficiency (HP:0002720)2.09448692
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08747397
65Epiphyseal dysplasia (HP:0002656)2.08501854
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07624845
67Eczematoid dermatitis (HP:0000976)2.06894748
68Abnormality of the ileum (HP:0001549)2.03962725
69Septate vagina (HP:0001153)2.00820206
70Postnatal microcephaly (HP:0005484)2.00699620
71Aseptic necrosis (HP:0010885)2.00358734
72Abnormality of cells of the erythroid lineage (HP:0012130)2.00033075
73Asymmetry of the thorax (HP:0001555)1.99623776
74Absent thumb (HP:0009777)1.98755205
75Increased hepatocellular lipid droplets (HP:0006565)1.97888638
76Vertebral compression fractures (HP:0002953)1.97867484
77Type I transferrin isoform profile (HP:0003642)1.96026183
78Uterine neoplasm (HP:0010784)1.95877029
79Overlapping toe (HP:0001845)1.95619153
80Abnormality of femoral epiphyses (HP:0006499)1.95495734
81Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.95495734
82Abnormalities of placenta or umbilical cord (HP:0001194)1.94998094
83Absent radius (HP:0003974)1.94902040
84Macrocytic anemia (HP:0001972)1.94621422
85Glioma (HP:0009733)1.94110760
86Sensory axonal neuropathy (HP:0003390)1.93965864
87Increased IgM level (HP:0003496)1.93874795
88Choanal atresia (HP:0000453)1.93360679
89Recurrent abscess formation (HP:0002722)1.92696873
90Colon cancer (HP:0003003)1.91831219
91Oral leukoplakia (HP:0002745)1.91721183
92Abnormality of the proximal phalanges of the hand (HP:0009834)1.91097697
93Breast carcinoma (HP:0003002)1.90655780
94Bone marrow hypocellularity (HP:0005528)1.89254559
95Microglossia (HP:0000171)1.88212091
96Cleft eyelid (HP:0000625)1.87398854
97Genu varum (HP:0002970)1.86974101
98Abnormality of the epiphysis of the femoral head (HP:0010574)1.86968333
99Abnormal trabecular bone morphology (HP:0100671)1.86959165
100Abnormality of the fetal cardiovascular system (HP:0010948)1.86155844
101Abnormal umbilical cord blood vessels (HP:0011403)1.86155844
102Single umbilical artery (HP:0001195)1.86155844
103Clubbing of toes (HP:0100760)1.85280467
104Increased density of long bones (HP:0006392)1.85111520
105Sloping forehead (HP:0000340)1.85003240
106Missing ribs (HP:0000921)1.84700583
107Abnormality of the labia minora (HP:0012880)1.84679142
108T lymphocytopenia (HP:0005403)1.84652747
109Arteriovenous malformation (HP:0100026)1.84335673
110Cutaneous melanoma (HP:0012056)1.83603352
111Cupped ribs (HP:0000887)1.83129101
112Neoplasm of the adrenal gland (HP:0100631)1.82510059
113Hypoplasia of the pons (HP:0012110)1.81241898
114Pancytopenia (HP:0001876)1.81225187
115Reduced antithrombin III activity (HP:0001976)1.80903264
116Biliary tract neoplasm (HP:0100574)1.80871887
117Flattened epiphyses (HP:0003071)1.80628634
118Small intestinal stenosis (HP:0012848)1.80606358
119Duodenal stenosis (HP:0100867)1.80606358
120Megaloblastic anemia (HP:0001889)1.80542389
121Pallor (HP:0000980)1.80260474
122Pulmonary fibrosis (HP:0002206)1.79881947
123Acute myeloid leukemia (HP:0004808)1.79790381
124Deviation of the thumb (HP:0009603)1.78675271
125Neuroblastic tumors (HP:0004376)1.78114082
126Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.78114082
127Neuroblastoma (HP:0003006)1.78114082
128Primitive neuroectodermal tumor (HP:0030065)1.78114082
129Gastrointestinal infarctions (HP:0005244)1.77985964
130Medulloblastoma (HP:0002885)1.77246405
131Absent forearm bone (HP:0003953)1.76653993
132Aplasia involving forearm bones (HP:0009822)1.76653993
133Abnormality of T cells (HP:0002843)1.76651207
134Delayed epiphyseal ossification (HP:0002663)1.76466037
135Abnormal number of erythroid precursors (HP:0012131)1.75394990
136Embryonal neoplasm (HP:0002898)1.75373716
137Slender long bone (HP:0003100)1.74277293
138Rib fusion (HP:0000902)1.73942233
139Hand muscle atrophy (HP:0009130)1.73821538
140Poor head control (HP:0002421)1.73486310
141Lipid accumulation in hepatocytes (HP:0006561)1.73094388
142Cafe-au-lait spot (HP:0000957)1.72789334
143Abnormality of the femoral head (HP:0003368)1.72604208
144Symptomatic seizures (HP:0011145)1.71581680
145Recurrent viral infections (HP:0004429)1.71580955
146Neoplasm of the pancreas (HP:0002894)1.71579576
147Thin ribs (HP:0000883)1.71220742
148Ovarian neoplasm (HP:0100615)1.71001845
149Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67975027
150Lymphoma (HP:0002665)1.67802274
151Tracheoesophageal fistula (HP:0002575)1.67778513
152Autoimmune thrombocytopenia (HP:0001973)1.67669977
153Rhabdomyosarcoma (HP:0002859)1.66876737
154Upper limb muscle weakness (HP:0003484)1.65460785
155Secondary amenorrhea (HP:0000869)1.65195948
156Abnormality of the pons (HP:0007361)1.64678077
157Recurrent bacterial skin infections (HP:0005406)1.63783457
158Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63666553
159Vertebral hypoplasia (HP:0008417)1.63666553
160Mild short stature (HP:0003502)1.63489624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.85590133
2BUB13.33370617
3EIF2AK13.10943870
4PLK42.40430091
5NEK22.39382749
6WEE12.25883789
7TTK2.04754412
8TAF12.00335318
9EEF2K2.00084053
10NME21.99509773
11RPS6KA41.99311252
12EIF2AK31.95686791
13ZAK1.93108786
14PBK1.85144815
15PIM21.84782732
16VRK21.83206159
17STK101.77730220
18TESK21.77247738
19JAK31.77121787
20TRIM281.75750101
21BRSK21.70885486
22PASK1.68814452
23MAP3K141.61153924
24PLK11.61038254
25NEK11.60906232
26SMG11.60857266
27ACVR1B1.60189841
28TESK11.60036458
29CDK121.58809275
30TLK11.55766867
31MAP3K81.54428308
32NME11.48554590
33IRAK31.47039668
34SRPK11.42654031
35AURKB1.41183973
36PIM11.35860768
37PLK31.31058815
38ATR1.30918015
39TSSK61.28264551
40VRK11.26507965
41STK41.24175381
42NEK91.22516803
43IKBKB1.21730925
44RPS6KB21.16408519
45SCYL21.16325285
46MAP4K11.15553124
47MAP3K101.14451725
48CHEK11.10593742
49CHUK1.09811952
50CDK71.07180599
51STK161.04987215
52LATS21.04239856
53CDK41.02948696
54STK31.02203965
55TYK21.02081260
56BRSK11.01875011
57CHEK21.01689060
58CLK11.00451692
59MST1R0.99396633
60STK38L0.99341717
61AURKA0.98543562
62MAP3K30.98489689
63EPHA20.97036597
64TBK10.96708010
65PKN20.94045676
66MST40.91350348
67ZAP700.90591247
68MELK0.89866018
69BRAF0.88694558
70LRRK20.86562585
71BRD40.85652575
72PAK40.84805813
73NUAK10.83653415
74MOS0.82853613
75LIMK10.81876497
76SIK30.80608967
77TAOK30.79394423
78FLT30.79252493
79MKNK10.78516874
80IRAK40.76777918
81EIF2AK20.76384710
82ATM0.76023003
83ERBB40.75201054
84PAK10.73164945
85MAP3K110.71594901
86TRIB30.70291529
87MAPKAPK30.67968192
88BLK0.67365897
89LATS10.66469353
90ALK0.66317839
91CDK20.64935760
92CDK60.64579167
93RPS6KA50.60499857
94BCR0.58791936
95TRPM70.58707780
96TGFBR10.58426316
97BMX0.58076181
98ABL20.54157782
99DYRK20.53739786
100FGFR10.53689552
101CDK80.53415823
102MAPKAPK20.51873457
103RAF10.50585323
104CSNK2A20.50356792
105MAP2K30.49216737
106TXK0.49187542
107MARK30.48871381
108MAP3K50.48817732
109ERBB30.48020910
110MAP3K120.47989549
111IKBKE0.45978841
112TNIK0.45348720
113DYRK30.44406419
114CSNK2A10.44182206
115PDK20.43287371
116CDK10.42453193
117STK240.42292364
118PRKCI0.41095832
119NLK0.39181792
120MKNK20.39076170
121ARAF0.38539774
122CCNB10.38272333
123STK390.38158480
124BMPR20.36997421
125CSNK1E0.35682557
126PAK20.34455766
127AKT20.33353482
128CDK90.29348339
129MET0.29256154
130DAPK10.29025966
131PDGFRA0.27098569
132ILK0.26971631
133PRKDC0.26829917
134BMPR1B0.26422984
135MAP3K90.25564072
136PLK20.23825822
137YES10.23556221

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80078795
2Mismatch repair_Homo sapiens_hsa034303.17741095
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94887486
4Proteasome_Homo sapiens_hsa030502.75375287
5RNA transport_Homo sapiens_hsa030132.58243322
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52954028
7Cell cycle_Homo sapiens_hsa041102.48756599
8Base excision repair_Homo sapiens_hsa034102.42021942
9Homologous recombination_Homo sapiens_hsa034402.37897611
10* One carbon pool by folate_Homo sapiens_hsa006702.31044004
11Spliceosome_Homo sapiens_hsa030402.30490495
12RNA polymerase_Homo sapiens_hsa030202.25391608
13Ribosome_Homo sapiens_hsa030102.24827755
14Nucleotide excision repair_Homo sapiens_hsa034202.19482842
15Vitamin B6 metabolism_Homo sapiens_hsa007502.13873148
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93746241
17p53 signaling pathway_Homo sapiens_hsa041151.81137680
18RNA degradation_Homo sapiens_hsa030181.71293410
19Fanconi anemia pathway_Homo sapiens_hsa034601.68937934
20Allograft rejection_Homo sapiens_hsa053301.68906050
21Pyrimidine metabolism_Homo sapiens_hsa002401.68309520
22Basal transcription factors_Homo sapiens_hsa030221.58458608
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57174390
24Non-homologous end-joining_Homo sapiens_hsa034501.56820910
25Protein export_Homo sapiens_hsa030601.50430784
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44522431
27Graft-versus-host disease_Homo sapiens_hsa053321.41179629
28Legionellosis_Homo sapiens_hsa051341.40780508
29Herpes simplex infection_Homo sapiens_hsa051681.39377926
30Type I diabetes mellitus_Homo sapiens_hsa049401.39012604
31Epstein-Barr virus infection_Homo sapiens_hsa051691.36857238
32mRNA surveillance pathway_Homo sapiens_hsa030151.34556339
33Antigen processing and presentation_Homo sapiens_hsa046121.32890574
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.28479401
35Viral carcinogenesis_Homo sapiens_hsa052031.26548336
36Carbon metabolism_Homo sapiens_hsa012001.26400382
37Measles_Homo sapiens_hsa051621.26207766
38Apoptosis_Homo sapiens_hsa042101.18093267
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09687255
40Leishmaniasis_Homo sapiens_hsa051401.08379043
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.05826041
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05061058
43Pyruvate metabolism_Homo sapiens_hsa006201.03257021
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02380867
45Pentose phosphate pathway_Homo sapiens_hsa000301.01534955
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00400757
47Influenza A_Homo sapiens_hsa051640.99950815
48Autoimmune thyroid disease_Homo sapiens_hsa053200.98594574
49HTLV-I infection_Homo sapiens_hsa051660.98590142
50Hepatitis B_Homo sapiens_hsa051610.90685148
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90631197
52Shigellosis_Homo sapiens_hsa051310.90387071
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90124368
54Steroid biosynthesis_Homo sapiens_hsa001000.89899426
55Systemic lupus erythematosus_Homo sapiens_hsa053220.88436974
56Viral myocarditis_Homo sapiens_hsa054160.87788351
57Small cell lung cancer_Homo sapiens_hsa052220.86894949
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86371885
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85833015
60MicroRNAs in cancer_Homo sapiens_hsa052060.85574646
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80816427
62Primary immunodeficiency_Homo sapiens_hsa053400.80219980
63TNF signaling pathway_Homo sapiens_hsa046680.77986248
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77737771
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75508482
66N-Glycan biosynthesis_Homo sapiens_hsa005100.74069691
67Asthma_Homo sapiens_hsa053100.73383680
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71786325
69Chronic myeloid leukemia_Homo sapiens_hsa052200.71378250
70Toxoplasmosis_Homo sapiens_hsa051450.71311860
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70460289
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69768736
73Glutathione metabolism_Homo sapiens_hsa004800.68868283
74Purine metabolism_Homo sapiens_hsa002300.68729684
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67963220
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.66230906
77Selenocompound metabolism_Homo sapiens_hsa004500.65951960
78Pancreatic cancer_Homo sapiens_hsa052120.65635872
79Thyroid cancer_Homo sapiens_hsa052160.65581045
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.64931871
81TGF-beta signaling pathway_Homo sapiens_hsa043500.64346534
82Bladder cancer_Homo sapiens_hsa052190.62911182
83Malaria_Homo sapiens_hsa051440.61808586
84Oocyte meiosis_Homo sapiens_hsa041140.58581016
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57993613
86Hematopoietic cell lineage_Homo sapiens_hsa046400.56439757
87Fatty acid elongation_Homo sapiens_hsa000620.56355475
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54992905
89Propanoate metabolism_Homo sapiens_hsa006400.53252898
90HIF-1 signaling pathway_Homo sapiens_hsa040660.50727632
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50503430
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49986282
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49937941
94Prostate cancer_Homo sapiens_hsa052150.49625437
95Colorectal cancer_Homo sapiens_hsa052100.49554821
96Tuberculosis_Homo sapiens_hsa051520.48566292
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48547079
98Acute myeloid leukemia_Homo sapiens_hsa052210.47747524
99Prolactin signaling pathway_Homo sapiens_hsa049170.46013373
100Osteoclast differentiation_Homo sapiens_hsa043800.45790361
101T cell receptor signaling pathway_Homo sapiens_hsa046600.45186258
102Fructose and mannose metabolism_Homo sapiens_hsa000510.43887340
103Folate biosynthesis_Homo sapiens_hsa007900.41376071
104Sulfur metabolism_Homo sapiens_hsa009200.40206516
105Adherens junction_Homo sapiens_hsa045200.39444078
106Galactose metabolism_Homo sapiens_hsa000520.39395309
107Other glycan degradation_Homo sapiens_hsa005110.38582467
108Pertussis_Homo sapiens_hsa051330.38002949
109Biosynthesis of amino acids_Homo sapiens_hsa012300.37892845
110Hippo signaling pathway_Homo sapiens_hsa043900.35443616
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35124276
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34973377
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33885047
114Rheumatoid arthritis_Homo sapiens_hsa053230.33849983
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.33712497
116Huntingtons disease_Homo sapiens_hsa050160.33564003
117Notch signaling pathway_Homo sapiens_hsa043300.32731159
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32597297
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.32255493
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32245257
121Lysine degradation_Homo sapiens_hsa003100.32090615
122Salmonella infection_Homo sapiens_hsa051320.31475625
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31128821
124Phagosome_Homo sapiens_hsa041450.30860561
125Chemokine signaling pathway_Homo sapiens_hsa040620.30634434
126B cell receptor signaling pathway_Homo sapiens_hsa046620.29793724
127Parkinsons disease_Homo sapiens_hsa050120.28353465
128* Metabolic pathways_Homo sapiens_hsa011000.26901420
129Proteoglycans in cancer_Homo sapiens_hsa052050.19989706
130Arginine and proline metabolism_Homo sapiens_hsa003300.19603681
131Melanoma_Homo sapiens_hsa052180.19544208
132Alcoholism_Homo sapiens_hsa050340.19177605
133Oxidative phosphorylation_Homo sapiens_hsa001900.18174789
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16037400
135Fatty acid metabolism_Homo sapiens_hsa012120.11545537
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11371445
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08078453

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