MTG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.62322117
2proteasome assembly (GO:0043248)5.23364553
3positive regulation of histone deacetylation (GO:0031065)5.12434646
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.62616041
5rRNA catabolic process (GO:0016075)4.34862613
6daunorubicin metabolic process (GO:0044597)4.28122920
7polyketide metabolic process (GO:0030638)4.28122920
8doxorubicin metabolic process (GO:0044598)4.28122920
9DNA damage response, signal transduction resulting in transcription (GO:0042772)4.25241240
10telomere maintenance via semi-conservative replication (GO:0032201)4.16691475
11positive regulation of protein deacetylation (GO:0090312)4.02784903
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98983245
13tRNA methylation (GO:0030488)3.89581583
14positive regulation by host of viral transcription (GO:0043923)3.89174279
15rRNA modification (GO:0000154)3.83782844
16sphingosine metabolic process (GO:0006670)3.83517125
17telomere maintenance via recombination (GO:0000722)3.76664698
18behavioral response to nicotine (GO:0035095)3.74375116
19termination of RNA polymerase III transcription (GO:0006386)3.67218342
20transcription elongation from RNA polymerase III promoter (GO:0006385)3.67218342
21opioid receptor signaling pathway (GO:0038003)3.61957921
22negative regulation of DNA-templated transcription, elongation (GO:0032785)3.61173078
23ribosomal small subunit assembly (GO:0000028)3.60734019
24N-acetylneuraminate metabolic process (GO:0006054)3.57608685
25deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.54632577
26positive regulation of triglyceride biosynthetic process (GO:0010867)3.53362030
27negative regulation of telomere maintenance (GO:0032205)3.52466689
28phosphatidylglycerol biosynthetic process (GO:0006655)3.50400063
29tRNA modification (GO:0006400)3.49831642
30regulation of hippo signaling (GO:0035330)3.46725312
31protein K6-linked ubiquitination (GO:0085020)3.45986332
32cellular response to interferon-beta (GO:0035458)3.44758680
33ubiquinone biosynthetic process (GO:0006744)3.43013451
34diol metabolic process (GO:0034311)3.41830195
35positive regulation of T cell apoptotic process (GO:0070234)3.41487884
36kynurenine metabolic process (GO:0070189)3.39773862
37DNA strand elongation involved in DNA replication (GO:0006271)3.38554981
38telomere maintenance via telomere lengthening (GO:0010833)3.38443340
39DNA strand elongation (GO:0022616)3.35413993
40negative regulation of histone acetylation (GO:0035067)3.35164529
41misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.34364832
42sphingoid metabolic process (GO:0046519)3.33397796
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.33010703
44pseudouridine synthesis (GO:0001522)3.28757903
45mitotic recombination (GO:0006312)3.28753744
46DNA integration (GO:0015074)3.28395936
47rRNA methylation (GO:0031167)3.27953424
48regulation of triglyceride biosynthetic process (GO:0010866)3.27884635
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.26006241
50metallo-sulfur cluster assembly (GO:0031163)3.25815910
51iron-sulfur cluster assembly (GO:0016226)3.25815910
52mitochondrial RNA metabolic process (GO:0000959)3.25411202
53respiratory chain complex IV assembly (GO:0008535)3.22542262
54ncRNA 3-end processing (GO:0043628)3.18089275
55mannosylation (GO:0097502)3.17795920
56folic acid metabolic process (GO:0046655)3.17690290
57negative regulation of B cell apoptotic process (GO:0002903)3.16635663
58viral mRNA export from host cell nucleus (GO:0046784)3.14938330
59tRNA processing (GO:0008033)3.14858071
60regulation of histone deacetylation (GO:0031063)3.13980518
61DNA replication initiation (GO:0006270)3.13136588
62deoxyribonucleotide biosynthetic process (GO:0009263)3.12702923
63tryptophan catabolic process (GO:0006569)3.11677195
64indole-containing compound catabolic process (GO:0042436)3.11677195
65indolalkylamine catabolic process (GO:0046218)3.11677195
66protein complex biogenesis (GO:0070271)3.10674335
67mitochondrial calcium ion transport (GO:0006851)3.08895569
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08540340
69tryptophan metabolic process (GO:0006568)3.07977512
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07540317
71cellular response to exogenous dsRNA (GO:0071360)3.06181385
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06079419
73positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05047264
74CENP-A containing nucleosome assembly (GO:0034080)3.04256257
75phosphatidylethanolamine biosynthetic process (GO:0006646)3.03966600
76response to misfolded protein (GO:0051788)3.03736213
77peptidyl-histidine modification (GO:0018202)3.03661188
78response to interferon-beta (GO:0035456)3.03418512
79interferon-gamma secretion (GO:0072643)3.03028468
80transcription-coupled nucleotide-excision repair (GO:0006283)3.02703040
81negative regulation of execution phase of apoptosis (GO:1900118)3.02571515
82regulation of defense response to virus by host (GO:0050691)3.02108183
83DNA-dependent DNA replication (GO:0006261)3.01250695
84kinetochore assembly (GO:0051382)3.00580307
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.00487356
86* regulation of mitochondrial translation (GO:0070129)3.00446526
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98422877
882-deoxyribonucleotide biosynthetic process (GO:0009265)2.97458991
89deoxyribose phosphate biosynthetic process (GO:0046385)2.97458991
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96986898
91DNA catabolic process, exonucleolytic (GO:0000738)2.96701666
92termination of RNA polymerase I transcription (GO:0006363)2.96210266
93cytochrome complex assembly (GO:0017004)2.95877871
94positive regulation of lymphocyte apoptotic process (GO:0070230)2.95391593
95RNA methylation (GO:0001510)2.93534205
96mitochondrial DNA replication (GO:0006264)2.93487489
97negative regulation of cell size (GO:0045792)2.92932177
98regulation of hydrogen peroxide metabolic process (GO:0010310)2.92342225
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91221621
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91221621
101telomere maintenance (GO:0000723)2.90618257
102telomere organization (GO:0032200)2.90418235
103DNA methylation involved in gamete generation (GO:0043046)2.90043882
104mitochondrial respiratory chain complex assembly (GO:0033108)2.89537993
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88238176
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.88238176
107NADH dehydrogenase complex assembly (GO:0010257)2.88238176
108positive regulation of CREB transcription factor activity (GO:0032793)2.88164723
109positive regulation of defense response to virus by host (GO:0002230)2.88089821
110transcription from RNA polymerase I promoter (GO:0006360)2.87642070
111lipopolysaccharide biosynthetic process (GO:0009103)2.87568615
112chromatin remodeling at centromere (GO:0031055)2.87325994
113transcription elongation from RNA polymerase I promoter (GO:0006362)2.87153177
114negative regulation of cAMP-mediated signaling (GO:0043951)2.86932959
115negative regulation of viral release from host cell (GO:1902187)2.86768730
116GDP-mannose metabolic process (GO:0019673)2.86052055
117pyrimidine-containing compound salvage (GO:0008655)2.85698189
118pyrimidine nucleoside salvage (GO:0043097)2.85698189
119negative regulation of cell cycle arrest (GO:0071157)2.83106965
120piRNA metabolic process (GO:0034587)2.82971332
121snRNA transcription (GO:0009301)2.81860424
122nucleobase biosynthetic process (GO:0046112)2.79290859
123spliceosomal snRNP assembly (GO:0000387)2.79223506
124amino acid salvage (GO:0043102)2.78943914
125L-methionine salvage (GO:0071267)2.78943914
126L-methionine biosynthetic process (GO:0071265)2.78943914
127maturation of SSU-rRNA (GO:0030490)2.76146810
128regulation of translational fidelity (GO:0006450)2.75721785
1297-methylguanosine mRNA capping (GO:0006370)2.75655400
130DNA replication checkpoint (GO:0000076)2.75330071
131quinone biosynthetic process (GO:1901663)2.75310451
132DNA damage response, detection of DNA damage (GO:0042769)2.74419898
133negative regulation of mast cell activation (GO:0033004)2.74113479
134maturation of 5.8S rRNA (GO:0000460)2.72958405
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.72833076
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71260369
137tRNA metabolic process (GO:0006399)2.71222247
138purine nucleobase biosynthetic process (GO:0009113)2.70794149
139RNA capping (GO:0036260)2.70693164
1407-methylguanosine RNA capping (GO:0009452)2.70693164
141basic amino acid transport (GO:0015802)2.70235744
142ubiquinone metabolic process (GO:0006743)2.70180170
143pantothenate metabolic process (GO:0015939)2.69147348
144rRNA processing (GO:0006364)2.68652720
145GPI anchor biosynthetic process (GO:0006506)2.67602414
146snRNA metabolic process (GO:0016073)2.66145291
147signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65832826
148signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65832826
149signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65832826
150aminoglycoside antibiotic metabolic process (GO:0030647)2.63937751
151* ribosome biogenesis (GO:0042254)2.63284331
152RNA modification (GO:0009451)2.63128550
153base-excision repair, AP site formation (GO:0006285)2.62944766
154transcription from mitochondrial promoter (GO:0006390)2.62684983
155deoxyribonucleotide metabolic process (GO:0009262)2.62613358
156regulation of T cell mediated cytotoxicity (GO:0001914)2.62095420
157phosphatidylethanolamine metabolic process (GO:0046337)2.61952579
158kinetochore organization (GO:0051383)2.60619398
159snRNA processing (GO:0016180)2.60543918
160indolalkylamine metabolic process (GO:0006586)2.59373054
161negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59057431
162cellular ketone body metabolic process (GO:0046950)2.58816188
163positive regulation of fatty acid oxidation (GO:0046321)2.58701879
164protein K63-linked ubiquitination (GO:0070534)2.58528630
165rRNA metabolic process (GO:0016072)2.57538416
166DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.56880707
167ncRNA processing (GO:0034470)2.56225248
168intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55429386
169signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55429386
1702-deoxyribonucleotide metabolic process (GO:0009394)2.55349379
171preassembly of GPI anchor in ER membrane (GO:0016254)2.54583981
172centriole assembly (GO:0098534)2.54038442
173positive regulation of protein homooligomerization (GO:0032464)2.53694565
174poly(A)+ mRNA export from nucleus (GO:0016973)2.53129493
175proline biosynthetic process (GO:0006561)2.53112578
176positive regulation of histone acetylation (GO:0035066)2.52822169
177adenosine metabolic process (GO:0046085)2.52534652
178signal transduction involved in cell cycle checkpoint (GO:0072395)2.52477073
179cardiolipin metabolic process (GO:0032048)2.52305683
180autophagic vacuole fusion (GO:0000046)2.51102919
181motile cilium assembly (GO:0044458)2.49998525
182adaptation of signaling pathway (GO:0023058)2.48257841
183cellular response to ATP (GO:0071318)2.46882432
184lipopolysaccharide metabolic process (GO:0008653)2.46200777
185regulation of viral release from host cell (GO:1902186)2.44779584
186cytokine biosynthetic process (GO:0042089)2.40354460
187modulation by symbiont of host defense response (GO:0052031)2.40182757
188modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.40182757
189positive regulation by organism of defense response of other organism involved in symbiotic interact2.40182757
190modulation by symbiont of host immune response (GO:0052553)2.40182757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88356282
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.07999481
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.85500935
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78991023
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.63595378
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.57298844
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.30846189
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26290094
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.13192939
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.78356486
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73935190
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.72046899
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71595995
14VDR_21846776_ChIP-Seq_THP-1_Human2.67061683
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.60476263
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55569728
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52804961
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52063988
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51621716
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39961819
21P68_20966046_ChIP-Seq_HELA_Human2.39927846
22VDR_23849224_ChIP-Seq_CD4+_Human2.38838233
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36134870
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27512253
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27034604
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21423079
27MYC_22102868_ChIP-Seq_BL_Human2.21345792
28LXR_22292898_ChIP-Seq_THP-1_Human2.21213751
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14044340
30FOXP3_21729870_ChIP-Seq_TREG_Human2.10253712
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.06476435
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04498974
33BCOR_27268052_Chip-Seq_Bcells_Human2.01568339
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01506509
35BCL6_27268052_Chip-Seq_Bcells_Human1.99781295
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97439073
37KDM5A_27292631_Chip-Seq_BREAST_Human1.96289758
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.96042979
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94717586
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90195654
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89296602
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88227540
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86729030
44ELK1_19687146_ChIP-ChIP_HELA_Human1.84695038
45E2F1_20622854_ChIP-Seq_HELA_Human1.83644763
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.83586715
47DCP1A_22483619_ChIP-Seq_HELA_Human1.83563212
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82450611
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80275653
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.79833309
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79614103
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79412838
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78897066
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78209672
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.77189371
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76842526
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76041133
58PHF8_20622854_ChIP-Seq_HELA_Human1.73109228
59SMC4_20622854_ChIP-Seq_HELA_Human1.72020173
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71217722
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68982530
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68513928
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68487424
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66402558
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.66137561
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.65305071
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64418613
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63650902
69IRF1_19129219_ChIP-ChIP_H3396_Human1.61281281
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61271689
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59657580
72GABP_19822575_ChIP-Seq_HepG2_Human1.56233346
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55388831
74MAF_26560356_Chip-Seq_TH2_Human1.54781692
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54744892
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54514717
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52731350
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.52541181
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50796636
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.50049141
81RACK7_27058665_Chip-Seq_MCF-7_Human1.49590837
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.48651503
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48207428
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.46351694
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45531402
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45292604
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45004387
88CTCF_20526341_ChIP-Seq_ESCs_Human1.42914385
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.42799192
90RARB_24833708_ChIP-Seq_LIVER_Mouse1.42378516
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41487329
92XRN2_22483619_ChIP-Seq_HELA_Human1.41313570
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41079756
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.41054099
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40962406
96SA1_27219007_Chip-Seq_Bcells_Human1.40174458
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39438051
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39382309
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38633393
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37538642
101P300_27268052_Chip-Seq_Bcells_Human1.36450118
102RAC3_21632823_ChIP-Seq_H3396_Human1.36330515
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36009759
104MAF_26560356_Chip-Seq_TH1_Human1.33072445
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31408309
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.31379700
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31097378
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.31019632
109FOXP1_21924763_ChIP-Seq_HESCs_Human1.28094384
110TTF2_22483619_ChIP-Seq_HELA_Human1.27902897
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27902565
112MYC_18940864_ChIP-ChIP_HL60_Human1.27402110
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27160451
114CIITA_25753668_ChIP-Seq_RAJI_Human1.26461641
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25618124
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25543667
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25062987
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24530552
119TP53_22127205_ChIP-Seq_IMR90_Human1.23309799
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22534235
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22430659
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21416710
123TP63_22573176_ChIP-Seq_HFKS_Human1.20443247
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19285696
125ERA_21632823_ChIP-Seq_H3396_Human1.18694199
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18439310
127PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17781997
128CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15464413
129ETS1_21867929_ChIP-Seq_TH2_Mouse1.15204832
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14565826
131UTX_26944678_Chip-Seq_JUKART_Human1.14409314
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13309512
133KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13075953
134KDM2B_26808549_Chip-Seq_DND41_Human1.12881579
135VDR_24763502_ChIP-Seq_THP-1_Human1.12154220
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10833566
137SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09756245
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08930680
139E2F1_21310950_ChIP-Seq_MCF-7_Human1.08037931
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07777940
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07672263
142TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07477022
143CREB1_26743006_Chip-Seq_LNCaP_Human1.07472023
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07015280
145OCT4_19829295_ChIP-Seq_ESCs_Human1.06353733
146STAT1_20625510_ChIP-Seq_HELA_Human1.04943099
147BP1_19119308_ChIP-ChIP_Hs578T_Human1.04740402
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04025244
149EZH2_27294783_Chip-Seq_NPCs_Mouse1.03357499
150RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02544721
151ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01922492
152STAT3_18555785_Chip-Seq_ESCs_Mouse1.01890207
153PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01110342
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00607893
155SCL_19346495_ChIP-Seq_HPC-7_Human1.00534331
156STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99787278
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95635252
158SPI1_23547873_ChIP-Seq_NB4_Human0.94704240
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90515354
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.89196551
161ZFX_18555785_Chip-Seq_ESCs_Mouse0.88773908
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87609131
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86043190
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.84613957
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.83663775
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83272048
167ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81009726
168NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80855013
169SMAD1_18555785_Chip-Seq_ESCs_Mouse0.80411096
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80325508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.10098392
2MP0008058_abnormal_DNA_repair3.66326037
3MP0002132_abnormal_respiratory_system3.49505365
4MP0000566_synostosis3.41228023
5MP0006292_abnormal_olfactory_placode3.32752415
6MP0001873_stomach_inflammation3.05514984
7MP0008057_abnormal_DNA_replication3.01894122
8MP0003693_abnormal_embryo_hatching2.66398370
9MP0010094_abnormal_chromosome_stability2.62492314
10MP0001661_extended_life_span2.53430624
11MP0002139_abnormal_hepatobiliary_system2.52184342
12MP0005451_abnormal_body_composition2.43541268
13MP0005075_abnormal_melanosome_morpholog2.40302165
14MP0001188_hyperpigmentation2.40265729
15MP0002396_abnormal_hematopoietic_system2.28173376
16MP0005083_abnormal_biliary_tract2.28166954
17MP0005671_abnormal_response_to2.17145373
18MP0003941_abnormal_skin_development2.13316651
19MP0009697_abnormal_copulation2.09384306
20MP0009379_abnormal_foot_pigmentation2.07280888
21MP0002653_abnormal_ependyma_morphology2.07088724
22MP0004130_abnormal_muscle_cell2.04976331
23MP0003786_premature_aging2.04767139
24MP0000015_abnormal_ear_pigmentation2.02607351
25MP0005379_endocrine/exocrine_gland_phen2.02052081
26MP0003191_abnormal_cellular_cholesterol2.02012994
27MP0004381_abnormal_hair_follicle1.93712263
28MP0008872_abnormal_physiological_respon1.92416394
29MP0003763_abnormal_thymus_physiology1.91792892
30MP0004185_abnormal_adipocyte_glucose1.87750171
31MP0001986_abnormal_taste_sensitivity1.87447673
32MP0005174_abnormal_tail_pigmentation1.86828595
33MP0004233_abnormal_muscle_weight1.86282164
34MP0003111_abnormal_nucleus_morphology1.86155900
35MP0003123_paternal_imprinting1.85010431
36MP0003136_yellow_coat_color1.79853112
37MP0001835_abnormal_antigen_presentation1.77588121
38MP0002277_abnormal_respiratory_mucosa1.76927028
39MP0005171_absent_coat_pigmentation1.75235365
40MP0005409_darkened_coat_color1.74874371
41MP0006035_abnormal_mitochondrial_morpho1.74684722
42MP0003077_abnormal_cell_cycle1.70012615
43MP0009785_altered_susceptibility_to1.67801793
44MP0008007_abnormal_cellular_replicative1.66896251
45MP0008875_abnormal_xenobiotic_pharmacok1.65217514
46MP0004043_abnormal_pH_regulation1.64321521
47MP0003436_decreased_susceptibility_to1.63904363
48MP0005360_urolithiasis1.60808854
49MP0000427_abnormal_hair_cycle1.58542871
50MP0003724_increased_susceptibility_to1.57431515
51MP0003718_maternal_effect1.57108710
52MP0000003_abnormal_adipose_tissue1.55411923
53MP0003186_abnormal_redox_activity1.53224538
54MP0003183_abnormal_peptide_metabolism1.52385679
55MP0001346_abnormal_lacrimal_gland1.51093887
56MP0002095_abnormal_skin_pigmentation1.49441134
57MP0001853_heart_inflammation1.49216445
58MP0003195_calcinosis1.48064581
59MP0002876_abnormal_thyroid_physiology1.45109902
60MP0002148_abnormal_hypersensitivity_rea1.40761971
61MP0002970_abnormal_white_adipose1.35144131
62MP0000749_muscle_degeneration1.35080092
63MP0002638_abnormal_pupillary_reflex1.34537393
64MP0001764_abnormal_homeostasis1.34226456
65MP0000470_abnormal_stomach_morphology1.32200077
66MP0002163_abnormal_gland_morphology1.28381300
67MP0001348_abnormal_lacrimal_gland1.28025674
68MP0008260_abnormal_autophagy1.27000725
69MP0004957_abnormal_blastocyst_morpholog1.26799672
70MP0005025_abnormal_response_to1.26486386
71MP0003806_abnormal_nucleotide_metabolis1.25870378
72MP0000372_irregular_coat_pigmentation1.25542313
73MP0005058_abnormal_lysosome_morphology1.24634227
74MP0003879_abnormal_hair_cell1.24019777
75MP0000685_abnormal_immune_system1.23737581
76MP0006036_abnormal_mitochondrial_physio1.22970861
77MP0005645_abnormal_hypothalamus_physiol1.22881476
78MP0000750_abnormal_muscle_regeneration1.20818128
79MP0005319_abnormal_enzyme/_coenzyme1.20402649
80MP0001800_abnormal_humoral_immune1.18272083
81MP0008877_abnormal_DNA_methylation1.17929959
82MP0000490_abnormal_crypts_of1.12857119
83MP0002723_abnormal_immune_serum1.12381555
84MP0005389_reproductive_system_phenotype1.11160666
85MP0005076_abnormal_cell_differentiation1.10955792
86MP0002938_white_spotting1.10677211
87MP0002420_abnormal_adaptive_immunity1.10474934
88MP0000013_abnormal_adipose_tissue1.09919290
89MP0002102_abnormal_ear_morphology1.08868171
90MP0000358_abnormal_cell_content/1.08541733
91MP0001819_abnormal_immune_cell1.08468071
92MP0001529_abnormal_vocalization1.07431586
93MP0003787_abnormal_imprinting1.06519244
94MP0001119_abnormal_female_reproductive1.06495512
95MP0002398_abnormal_bone_marrow1.06433903
96MP0001919_abnormal_reproductive_system1.06093564
97MP0002452_abnormal_antigen_presenting1.05035034
98MP0003045_fibrosis1.03605318
99MP0008789_abnormal_olfactory_epithelium1.03309449
100MP0002160_abnormal_reproductive_system1.03264329
101MP0000689_abnormal_spleen_morphology1.03153861
102MP0005266_abnormal_metabolism1.00888149
103MP0003172_abnormal_lysosome_physiology1.00011712
104MP0000681_abnormal_thyroid_gland0.98649889
105MP0004858_abnormal_nervous_system0.98300616
106MP0002269_muscular_atrophy0.97326643
107MP0001790_abnormal_immune_system0.97080134
108MP0005387_immune_system_phenotype0.97080134
109MP0009333_abnormal_splenocyte_physiolog0.96289930
110MP0005647_abnormal_sex_gland0.95531336
111MP0000716_abnormal_immune_system0.95488163
112MP0008932_abnormal_embryonic_tissue0.94485599
113MP0002419_abnormal_innate_immunity0.94174494
114MP0009053_abnormal_anal_canal0.91915931
115MP0001186_pigmentation_phenotype0.91819084
116MP0005000_abnormal_immune_tolerance0.91487815
117MP0005365_abnormal_bile_salt0.90728760
118MP0005084_abnormal_gallbladder_morpholo0.90547701
119MP0005551_abnormal_eye_electrophysiolog0.89715208
120MP0001664_abnormal_digestion0.89712312
121MP0002429_abnormal_blood_cell0.89624373
122MP0004782_abnormal_surfactant_physiolog0.88978095
123MP0000609_abnormal_liver_physiology0.88880860
124MP0005334_abnormal_fat_pad0.88033006
125MP0005375_adipose_tissue_phenotype0.87876768
126MP0002405_respiratory_system_inflammati0.87638362
127MP0002722_abnormal_immune_system0.87521018
128MP0009643_abnormal_urine_homeostasis0.87381279
129MP0000703_abnormal_thymus_morphology0.87070312
130MP0002210_abnormal_sex_determination0.86843675
131MP0002693_abnormal_pancreas_physiology0.85947826
132MP0003950_abnormal_plasma_membrane0.85041842
133MP0009278_abnormal_bone_marrow0.82110760
134MP0000467_abnormal_esophagus_morphology0.81927774
135MP0000613_abnormal_salivary_gland0.81144506
136MP0005332_abnormal_amino_acid0.80980345
137MP0002249_abnormal_larynx_morphology0.80962589
138MP0000371_diluted_coat_color0.80134984
139MP0010386_abnormal_urinary_bladder0.79924013
140MP0005310_abnormal_salivary_gland0.79810830
141MP0009840_abnormal_foam_cell0.79606104
142MP0005220_abnormal_exocrine_pancreas0.79275100
143MP0002075_abnormal_coat/hair_pigmentati0.79212660
144MP0005646_abnormal_pituitary_gland0.78553895
145MP0001765_abnormal_ion_homeostasis0.78514968
146MP0004147_increased_porphyrin_level0.77243918
147MP0001905_abnormal_dopamine_level0.76002131
148MP0000678_abnormal_parathyroid_gland0.74129565
149MP0000858_altered_metastatic_potential0.73695962
150MP0008995_early_reproductive_senescence0.72321136
151MP0008469_abnormal_protein_level0.71976269
152MP0005670_abnormal_white_adipose0.71877578
153MP0002019_abnormal_tumor_incidence0.71669379
154MP0000313_abnormal_cell_death0.71076951
155MP0004145_abnormal_muscle_electrophysio0.70519605

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.83518915
2Chromsome breakage (HP:0040012)4.46738685
3Type II lissencephaly (HP:0007260)3.78702323
43-Methylglutaconic aciduria (HP:0003535)3.62022191
5Type I transferrin isoform profile (HP:0003642)3.58228431
6Concave nail (HP:0001598)3.46022645
7Partial agenesis of the corpus callosum (HP:0001338)3.44443301
8Clumsiness (HP:0002312)3.29110784
9Asymmetry of the thorax (HP:0001555)3.26046220
10Duplicated collecting system (HP:0000081)3.24817583
11Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21676112
12Birth length less than 3rd percentile (HP:0003561)3.18158394
13Type 2 muscle fiber atrophy (HP:0003554)3.17379134
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16811129
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16811129
16Fibular aplasia (HP:0002990)3.11446761
17Increased hepatocellular lipid droplets (HP:0006565)3.11392066
18Reduced antithrombin III activity (HP:0001976)3.06354693
19Abnormality of the preputium (HP:0100587)3.05710550
20Microvesicular hepatic steatosis (HP:0001414)3.05111149
21Bilateral microphthalmos (HP:0007633)3.00177857
22Reticulocytopenia (HP:0001896)2.99989246
23Entropion (HP:0000621)2.98013116
24Unilateral renal agenesis (HP:0000122)2.97307585
25Large for gestational age (HP:0001520)2.97082822
26Abnormality of the renal collecting system (HP:0004742)2.92767551
27Poikiloderma (HP:0001029)2.90377453
28Thoracic kyphosis (HP:0002942)2.87646898
29Testicular atrophy (HP:0000029)2.86579784
30Broad distal phalanx of finger (HP:0009836)2.85652432
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84065501
32Meckel diverticulum (HP:0002245)2.80457893
33Cerebellar dysplasia (HP:0007033)2.75191437
34Mitochondrial inheritance (HP:0001427)2.74532349
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.73202323
36Acute necrotizing encephalopathy (HP:0006965)2.73024936
37Squamous cell carcinoma (HP:0002860)2.72361993
38Severe combined immunodeficiency (HP:0004430)2.71407972
39Abnormality of the ileum (HP:0001549)2.69424600
40Muscle fiber atrophy (HP:0100295)2.68052659
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.63473021
42Lipid accumulation in hepatocytes (HP:0006561)2.63469154
43Increased serum lactate (HP:0002151)2.63369002
44Renal Fanconi syndrome (HP:0001994)2.60712144
45Natal tooth (HP:0000695)2.59109572
46Hepatocellular necrosis (HP:0001404)2.58756396
47Congenital stationary night blindness (HP:0007642)2.57335178
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57037847
49Ketosis (HP:0001946)2.54631937
50Abnormal mitochondria in muscle tissue (HP:0008316)2.54611296
51Abnormality of chromosome stability (HP:0003220)2.52053939
52Increased CSF lactate (HP:0002490)2.49983106
53Severe muscular hypotonia (HP:0006829)2.49800739
54Abnormality of liposaccharide metabolism (HP:0010968)2.48718309
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.48718309
56Abnormality of glycolipid metabolism (HP:0010969)2.48718309
57Abnormality of the thoracic spine (HP:0100711)2.43803885
58Increased serum ferritin (HP:0003281)2.43687285
59Aplastic anemia (HP:0001915)2.42500228
60Abnormal glycosylation (HP:0012345)2.41729578
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41729578
62Abnormal protein N-linked glycosylation (HP:0012347)2.41729578
63Abnormal protein glycosylation (HP:0012346)2.41729578
64Ketoacidosis (HP:0001993)2.41624075
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40750011
66Hepatic necrosis (HP:0002605)2.38713241
67Renal cortical cysts (HP:0000803)2.37410158
68Dry hair (HP:0011359)2.35355671
69Abnormality of pyrimidine metabolism (HP:0004353)2.34937797
70Progressive microcephaly (HP:0000253)2.34075089
71Abnormality of DNA repair (HP:0003254)2.33343769
72Hyperthyroidism (HP:0000836)2.32196451
73Hypochromic anemia (HP:0001931)2.31693573
74Abnormality of transition element cation homeostasis (HP:0011030)2.31334770
75Ragged-red muscle fibers (HP:0003200)2.29722340
76Hypoplasia of the fovea (HP:0007750)2.27749972
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.27749972
78Exertional dyspnea (HP:0002875)2.27097442
79Tubular atrophy (HP:0000092)2.26542626
80Abnormality of placental membranes (HP:0011409)2.25254111
81Amniotic constriction ring (HP:0009775)2.25254111
82Retinal dysplasia (HP:0007973)2.25195734
83Parakeratosis (HP:0001036)2.24944334
84Clubbing of toes (HP:0100760)2.24571717
85Cerebral palsy (HP:0100021)2.24495641
86Bone marrow hypocellularity (HP:0005528)2.21823023
87J-shaped sella turcica (HP:0002680)2.21321120
88Rough bone trabeculation (HP:0100670)2.20329338
89Abnormality of alanine metabolism (HP:0010916)2.19052897
90Hyperalaninemia (HP:0003348)2.19052897
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19052897
92Acute encephalopathy (HP:0006846)2.18904029
93Exercise intolerance (HP:0003546)2.16851609
94Increased cerebral lipofuscin (HP:0011813)2.15357362
95Lactic acidosis (HP:0003128)2.14667145
96Premature graying of hair (HP:0002216)2.12280762
97Abnormality of renal resorption (HP:0011038)2.11008558
98Granulocytopenia (HP:0001913)2.09294146
99Abnormality of the renal cortex (HP:0011035)2.07788843
100Fibular hypoplasia (HP:0003038)2.07573344
101Autoimmune thrombocytopenia (HP:0001973)2.07353838
102Combined immunodeficiency (HP:0005387)2.06822078
103Abnormality of iron homeostasis (HP:0011031)2.06300071
104Ectopic kidney (HP:0000086)2.04056291
105Mesangial abnormality (HP:0001966)2.02327679
106True hermaphroditism (HP:0010459)2.02055658
107Pancreatic cysts (HP:0001737)2.01531042
108Increased intramyocellular lipid droplets (HP:0012240)2.00623572
109Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00496188
110Abnormality of subcutaneous fat tissue (HP:0001001)1.98992843
111Microretrognathia (HP:0000308)1.98360527
112Reticulocytosis (HP:0001923)1.97941498
113Patellar aplasia (HP:0006443)1.97225474
114Pancytopenia (HP:0001876)1.96047314
115Myopathic facies (HP:0002058)1.95524844
116Small intestinal stenosis (HP:0012848)1.95492179
117Duodenal stenosis (HP:0100867)1.95492179
118Patchy hypopigmentation of hair (HP:0011365)1.95430703
119Oral leukoplakia (HP:0002745)1.95270245
120Progressive macrocephaly (HP:0004481)1.92965994
121Triphalangeal thumb (HP:0001199)1.92660870
122Truncus arteriosus (HP:0001660)1.92110096
123Prostate neoplasm (HP:0100787)1.89956499
124Attenuation of retinal blood vessels (HP:0007843)1.89016196
125Decreased subcutaneous fat (HP:0001002)1.88848646
126Stridor (HP:0010307)1.88825165
127Elevated erythrocyte sedimentation rate (HP:0003565)1.87678739
128Abnormality of cells of the erythroid lineage (HP:0012130)1.86296571
129Amelogenesis imperfecta (HP:0000705)1.85090226
130IgG deficiency (HP:0004315)1.84796203
131Pancreatic fibrosis (HP:0100732)1.84400426
132Pendular nystagmus (HP:0012043)1.83880200
133Aplasia/Hypoplasia of the patella (HP:0006498)1.82808638
134Cystic liver disease (HP:0006706)1.82240335
135Cheilitis (HP:0100825)1.82053376
136Optic neuritis (HP:0100653)1.82031409
137Retrobulbar optic neuritis (HP:0100654)1.82031409
138Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81954556
139Dicarboxylic aciduria (HP:0003215)1.81954556
140Progressive muscle weakness (HP:0003323)1.79769003
141Breast hypoplasia (HP:0003187)1.77904467
142Increased muscle lipid content (HP:0009058)1.77564337
143Abnormality of the prostate (HP:0008775)1.77316224
144Abnormal drinking behavior (HP:0030082)1.76939692
145Polydipsia (HP:0001959)1.76939692
146Absent/shortened dynein arms (HP:0200106)1.75315947
147Dynein arm defect of respiratory motile cilia (HP:0012255)1.75315947
148Absent thumb (HP:0009777)1.74994823
149Abnormal number of erythroid precursors (HP:0012131)1.74618069
150Cellular immunodeficiency (HP:0005374)1.74035782
151Abnormal spermatogenesis (HP:0008669)1.73200180
152Hypokinesia (HP:0002375)1.72972997
153Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72849334
154Methylmalonic aciduria (HP:0012120)1.72154165
155Flat capital femoral epiphysis (HP:0003370)1.71083250
156Conjugated hyperbilirubinemia (HP:0002908)1.70803302
157Respiratory difficulties (HP:0002880)1.70067156
158Progressive external ophthalmoplegia (HP:0000590)1.70022468
159Diaphragmatic weakness (HP:0009113)1.69555215
160Sparse eyelashes (HP:0000653)1.69063164
161Fair hair (HP:0002286)1.68490917
162Pallor (HP:0000980)1.68181687
163Severe visual impairment (HP:0001141)1.67683534
164Progressive inability to walk (HP:0002505)1.67596419
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67235460
166Myelodysplasia (HP:0002863)1.66289076
167Proximal tubulopathy (HP:0000114)1.65412509
168Opisthotonus (HP:0002179)1.65342023
169Chronic hepatic failure (HP:0100626)1.65050704
170Cerebral edema (HP:0002181)1.64866832
171Prolonged neonatal jaundice (HP:0006579)1.64419086
172Abnormal trabecular bone morphology (HP:0100671)1.64156918
173Mediastinal lymphadenopathy (HP:0100721)1.64053445
174Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63683617
175Dysostosis multiplex (HP:0000943)1.63032042
176Stomatitis (HP:0010280)1.62351018
177Tented upper lip vermilion (HP:0010804)1.61224797
178Sparse lateral eyebrow (HP:0005338)1.60467931
179Brittle hair (HP:0002299)1.59970269
180Hyperglycinuria (HP:0003108)1.59780176
181Abnormality of T cell physiology (HP:0011840)1.58750790
182Abnormality of the pons (HP:0007361)1.58745323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.86519828
2STK163.73038475
3SMG13.37671570
4ERN13.22172875
5MUSK3.07835185
6ZAK3.03932696
7IRAK32.96484545
8ICK2.85430644
9BUB12.82851725
10IRAK42.75602954
11TXK2.54137866
12ADRBK22.53721316
13SRPK12.53044853
14PLK42.50276375
15EPHA22.39779921
16VRK22.29152325
17CASK2.10669478
18TESK22.04975740
19MAPKAPK32.04623540
20EEF2K1.96298406
21VRK11.85056971
22NME21.78007678
23EIF2AK11.77142002
24MAP3K121.76832148
25NEK21.74443449
26FRK1.71977444
27MKNK21.70540799
28SIK21.67035048
29TNIK1.64145764
30YES11.64075261
31SIK31.62120251
32WNK41.54290074
33SIK11.51894831
34EIF2AK31.48317484
35WEE11.45489325
36PRKG21.42134512
37BRD41.41683549
38EIF2AK21.41481036
39MAP2K31.39392379
40MAP3K141.32751806
41AKT31.32611140
42MAPK111.32569810
43IKBKB1.31278880
44PRKD21.30985731
45GRK61.29525715
46CCNB11.26886995
47PRPF4B1.25135888
48INSRR1.24202723
49GRK11.21588054
50HIPK21.18410556
51CAMK1D1.17281281
52IRAK21.16051107
53MAP2K21.16022871
54RPS6KB21.15307160
55TEC1.15156100
56MKNK11.14999837
57ATR1.12583003
58BCKDK1.10825252
59TLK11.09816428
60BMPR21.07821315
61MAP3K31.05228026
62MST1R1.03952143
63MAP2K71.02475393
64MAP4K10.99133409
65CDK70.98584240
66PIM20.98121394
67PHKG20.97653524
68PHKG10.97653524
69IKBKE0.94273896
70GRK70.93665973
71IRAK10.93199531
72TBK10.91444210
73PRKAA20.90462290
74TSSK60.88083082
75CDK120.86980815
76DYRK30.86808620
77CHEK20.86557438
78PINK10.85597444
79STK38L0.85119292
80RPS6KA60.84743427
81BRAF0.84392540
82CDK80.82508194
83MAPKAPK50.81438762
84MAP3K70.79875384
85PLK10.79625006
86PRKAA10.77091926
87PDPK10.76821672
88TIE10.75974286
89TAOK30.74365019
90NUAK10.71999609
91PTK60.71983623
92ACVR1B0.71756939
93STK40.71751026
94TYK20.70091498
95PBK0.69752407
96MYLK0.69123284
97CHUK0.68158735
98DYRK20.67982349
99RIPK40.67970272
100NLK0.66624611
101TTK0.65356490
102MAP2K10.64836545
103CAMKK10.63388355
104LYN0.62709307
105RPS6KL10.62435620
106RPS6KC10.62435620
107MELK0.62002823
108RPS6KA50.61238820
109BTK0.60898824
110CSNK2A10.60805287
111KIT0.60723350
112TAOK20.59670192
113MARK30.58322924
114HCK0.58164012
115CDC70.58057465
116BLK0.57757996
117SGK20.57119132
118NME10.56128325
119PIM10.55939208
120PLK30.55850097
121OBSCN0.55366133
122TAOK10.54896905
123NEK60.54727027
124KDR0.54216263
125SYK0.53892812
126CLK10.53856926
127CDK30.52684759
128CDK40.52668427
129PTK2B0.52593884
130LIMK10.52190148
131PDK10.52024626
132MST40.51485359
133CAMK40.51300603
134PRKD30.51295440
135AURKB0.50585268
136ABL20.50539563
137AURKA0.50525924
138RPS6KA20.50484623
139STK110.50285505
140ZAP700.50212017
141BMPR1B0.49169226
142MTOR0.48989950
143BRSK20.48711159
144LMTK20.47431459
145MAPKAPK20.47084902
146RPS6KA40.46192855
147ATM0.45690137
148PRKCI0.45253575
149TNK20.43575094
150MAP2K60.42894828
151ADRBK10.42056488
152MAPK130.41726631
153CSNK2A20.41510608
154CHEK10.40246862
155MAPK120.39014254
156MAP3K110.38791700
157MATK0.38146624
158JAK30.36598556
159ERBB30.33307418
160MAPK70.32376028
161NEK90.28015057

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.71922642
2Homologous recombination_Homo sapiens_hsa034403.23963380
3Mismatch repair_Homo sapiens_hsa034303.22017551
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.20982300
5Proteasome_Homo sapiens_hsa030503.19529147
6RNA polymerase_Homo sapiens_hsa030203.19522523
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.13326469
8Base excision repair_Homo sapiens_hsa034103.00638908
9Ribosome_Homo sapiens_hsa030102.97274867
10Fanconi anemia pathway_Homo sapiens_hsa034602.94220287
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86345098
12Pyrimidine metabolism_Homo sapiens_hsa002402.68863786
13Non-homologous end-joining_Homo sapiens_hsa034502.44147020
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24654960
15Nucleotide excision repair_Homo sapiens_hsa034202.22242347
16Spliceosome_Homo sapiens_hsa030402.16379901
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12256420
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04194113
19Oxidative phosphorylation_Homo sapiens_hsa001901.97970978
20Basal transcription factors_Homo sapiens_hsa030221.93581576
21One carbon pool by folate_Homo sapiens_hsa006701.92322431
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90600791
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74221721
24Purine metabolism_Homo sapiens_hsa002301.68091524
25Lysine degradation_Homo sapiens_hsa003101.64923451
26Parkinsons disease_Homo sapiens_hsa050121.64236156
27Protein export_Homo sapiens_hsa030601.63835049
28Primary immunodeficiency_Homo sapiens_hsa053401.62330633
29RNA degradation_Homo sapiens_hsa030181.61052835
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.58785482
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57242187
32RNA transport_Homo sapiens_hsa030131.39150555
33Huntingtons disease_Homo sapiens_hsa050161.38494241
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25333084
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.24669706
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23891865
37Glycerolipid metabolism_Homo sapiens_hsa005611.17256234
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16168824
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.15817784
40Fatty acid biosynthesis_Homo sapiens_hsa000611.14900257
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13604083
42Graft-versus-host disease_Homo sapiens_hsa053321.13502211
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.11504027
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.11121163
45Notch signaling pathway_Homo sapiens_hsa043301.09294132
46Ovarian steroidogenesis_Homo sapiens_hsa049131.08018147
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07748312
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07040434
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03553858
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01064846
51Cell cycle_Homo sapiens_hsa041100.99312018
52Lysosome_Homo sapiens_hsa041420.99200021
53Alzheimers disease_Homo sapiens_hsa050100.96815845
54Allograft rejection_Homo sapiens_hsa053300.95640982
55T cell receptor signaling pathway_Homo sapiens_hsa046600.94269161
56Tryptophan metabolism_Homo sapiens_hsa003800.93903963
57mTOR signaling pathway_Homo sapiens_hsa041500.90663841
58Folate biosynthesis_Homo sapiens_hsa007900.90198438
59Herpes simplex infection_Homo sapiens_hsa051680.88623332
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87277821
61Biosynthesis of amino acids_Homo sapiens_hsa012300.86522732
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85758367
63Arachidonic acid metabolism_Homo sapiens_hsa005900.85623688
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83147869
65Autoimmune thyroid disease_Homo sapiens_hsa053200.81470684
66Peroxisome_Homo sapiens_hsa041460.80081431
67p53 signaling pathway_Homo sapiens_hsa041150.79358375
68B cell receptor signaling pathway_Homo sapiens_hsa046620.79193859
69Measles_Homo sapiens_hsa051620.78866829
70Vitamin B6 metabolism_Homo sapiens_hsa007500.78508933
71Insulin resistance_Homo sapiens_hsa049310.76370183
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76019695
73Other glycan degradation_Homo sapiens_hsa005110.75817067
74Phototransduction_Homo sapiens_hsa047440.75326486
75Acute myeloid leukemia_Homo sapiens_hsa052210.75061575
76VEGF signaling pathway_Homo sapiens_hsa043700.74006515
77Metabolic pathways_Homo sapiens_hsa011000.73944556
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73283213
79Arginine biosynthesis_Homo sapiens_hsa002200.71199618
80Vitamin digestion and absorption_Homo sapiens_hsa049770.71055394
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69970527
82Hematopoietic cell lineage_Homo sapiens_hsa046400.68540114
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68214934
84Epstein-Barr virus infection_Homo sapiens_hsa051690.67698568
85Bladder cancer_Homo sapiens_hsa052190.67282749
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67176289
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66971605
88Sulfur relay system_Homo sapiens_hsa041220.66753146
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64569257
90Osteoclast differentiation_Homo sapiens_hsa043800.64543571
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.64215628
92Regulation of autophagy_Homo sapiens_hsa041400.63833600
93Ether lipid metabolism_Homo sapiens_hsa005650.63590325
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.62479416
95AMPK signaling pathway_Homo sapiens_hsa041520.61813302
96Fatty acid elongation_Homo sapiens_hsa000620.61571951
97Nitrogen metabolism_Homo sapiens_hsa009100.61306821
98Hepatitis C_Homo sapiens_hsa051600.60735157
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.58767798
100Pentose phosphate pathway_Homo sapiens_hsa000300.56080036
101beta-Alanine metabolism_Homo sapiens_hsa004100.53569293
102mRNA surveillance pathway_Homo sapiens_hsa030150.52749490
103Glutathione metabolism_Homo sapiens_hsa004800.52037787
104Retinol metabolism_Homo sapiens_hsa008300.51789342
105TNF signaling pathway_Homo sapiens_hsa046680.50594845
106Systemic lupus erythematosus_Homo sapiens_hsa053220.50431568
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49942633
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49740199
109African trypanosomiasis_Homo sapiens_hsa051430.48277071
110Selenocompound metabolism_Homo sapiens_hsa004500.47706509
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47574563
112Apoptosis_Homo sapiens_hsa042100.46840489
113Rheumatoid arthritis_Homo sapiens_hsa053230.46090409
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46005878
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45849420
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45285292
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.44189967
118Chronic myeloid leukemia_Homo sapiens_hsa052200.44016149
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43426969
120Viral carcinogenesis_Homo sapiens_hsa052030.43027467
121Linoleic acid metabolism_Homo sapiens_hsa005910.42725946
122Asthma_Homo sapiens_hsa053100.42686783
123Caffeine metabolism_Homo sapiens_hsa002320.42069056
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41823882
125Influenza A_Homo sapiens_hsa051640.41061164
126Butanoate metabolism_Homo sapiens_hsa006500.39239840
127Non-small cell lung cancer_Homo sapiens_hsa052230.37446731
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36614478
129Sphingolipid metabolism_Homo sapiens_hsa006000.36121529
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34325965
131Arginine and proline metabolism_Homo sapiens_hsa003300.33714257
132Chemical carcinogenesis_Homo sapiens_hsa052040.33482757
133Insulin signaling pathway_Homo sapiens_hsa049100.32637988
134Legionellosis_Homo sapiens_hsa051340.32123415
135Antigen processing and presentation_Homo sapiens_hsa046120.31211499
136N-Glycan biosynthesis_Homo sapiens_hsa005100.31176344
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29324799
138Phenylalanine metabolism_Homo sapiens_hsa003600.29219138
139Fructose and mannose metabolism_Homo sapiens_hsa000510.29211309
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27932546
141Tyrosine metabolism_Homo sapiens_hsa003500.26549001
142Propanoate metabolism_Homo sapiens_hsa006400.26069135
143Taste transduction_Homo sapiens_hsa047420.25867703
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.25365466
145ABC transporters_Homo sapiens_hsa020100.22582590
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22279136

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