MTFR1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.17983901
2sarcomere organization (GO:0045214)5.04791853
3actin-myosin filament sliding (GO:0033275)4.86413599
4muscle filament sliding (GO:0030049)4.86413599
5lysine catabolic process (GO:0006554)4.75160734
6lysine metabolic process (GO:0006553)4.75160734
7glyoxylate metabolic process (GO:0046487)4.72055637
82-oxoglutarate metabolic process (GO:0006103)4.55754363
9fatty acid beta-oxidation (GO:0006635)4.53936938
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.42726249
11L-phenylalanine metabolic process (GO:0006558)4.42726249
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.35175244
13L-phenylalanine catabolic process (GO:0006559)4.35175244
14branched-chain amino acid catabolic process (GO:0009083)4.33118825
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32321742
16cardiac myofibril assembly (GO:0055003)4.31487363
17regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.28830672
18carnitine shuttle (GO:0006853)4.24405119
19succinate metabolic process (GO:0006105)4.19076642
20heart contraction (GO:0060047)4.17557284
21heart process (GO:0003015)4.17557284
22carnitine metabolic process (GO:0009437)4.15839548
23regulation of skeletal muscle contraction (GO:0014819)4.14311892
24NADH metabolic process (GO:0006734)4.11573815
25fatty acid transmembrane transport (GO:1902001)4.09960829
26aspartate family amino acid catabolic process (GO:0009068)4.09512898
27fatty acid catabolic process (GO:0009062)4.07826718
28sarcoplasmic reticulum calcium ion transport (GO:0070296)4.05481844
29oxidative phosphorylation (GO:0006119)4.04629625
30alpha-linolenic acid metabolic process (GO:0036109)4.03437787
31tricarboxylic acid metabolic process (GO:0072350)4.03083891
32myofibril assembly (GO:0030239)4.02949091
33amino-acid betaine metabolic process (GO:0006577)4.02199210
34branched-chain amino acid metabolic process (GO:0009081)4.01944733
35valine metabolic process (GO:0006573)3.96425078
36cellular ketone body metabolic process (GO:0046950)3.92642388
37actin-mediated cell contraction (GO:0070252)3.90873417
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.90200262
39fatty acid oxidation (GO:0019395)3.88081752
40lipid oxidation (GO:0034440)3.81046175
41oxaloacetate metabolic process (GO:0006107)3.78728056
42regulation of relaxation of muscle (GO:1901077)3.78523664
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.78379063
44regulation of fatty acid oxidation (GO:0046320)3.78136331
45carnitine transmembrane transport (GO:1902603)3.71833966
46regulation of acyl-CoA biosynthetic process (GO:0050812)3.70880477
47negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.69843021
48cardiac muscle contraction (GO:0060048)3.68660393
49acetyl-CoA metabolic process (GO:0006084)3.68396915
50negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.67296397
51negative regulation of calcium ion transmembrane transport (GO:1903170)3.67296397
52monocarboxylic acid catabolic process (GO:0072329)3.65313112
53carnitine transport (GO:0015879)3.64597648
54amino-acid betaine transport (GO:0015838)3.64597648
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59421874
56response to mercury ion (GO:0046689)3.58364119
57neuronal action potential propagation (GO:0019227)3.54177018
58aromatic amino acid family catabolic process (GO:0009074)3.50046065
59negative regulation of heart rate (GO:0010459)3.47024607
60regulation of sequestering of triglyceride (GO:0010889)3.46988111
61ethanol oxidation (GO:0006069)3.44753422
62respiratory electron transport chain (GO:0022904)3.38661796
63regulation of coenzyme metabolic process (GO:0051196)3.38205760
64regulation of cofactor metabolic process (GO:0051193)3.38205760
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36438966
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35111457
67cardiac muscle cell development (GO:0055013)3.34177962
68regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33844469
69negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.32871143
70electron transport chain (GO:0022900)3.31500435
71kynurenine metabolic process (GO:0070189)3.31391591
72ketone body metabolic process (GO:1902224)3.29361195
73short-chain fatty acid metabolic process (GO:0046459)3.26292076
74actomyosin structure organization (GO:0031032)3.22667083
75cardiac muscle hypertrophy (GO:0003300)3.19616236
76negative regulation of potassium ion transmembrane transport (GO:1901380)3.19509871
77quaternary ammonium group transport (GO:0015697)3.17504691
78coenzyme catabolic process (GO:0009109)3.14033285
79ubiquinone metabolic process (GO:0006743)3.13852421
80protein neddylation (GO:0045116)3.11348073
81ATP synthesis coupled proton transport (GO:0015986)3.10597982
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10597982
83cardiac muscle tissue morphogenesis (GO:0055008)3.09771364
84regulation of fatty acid beta-oxidation (GO:0031998)3.08686307
85response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.08361661
86cardiac cell development (GO:0055006)3.08360116
87organic acid catabolic process (GO:0016054)3.07304494
88carboxylic acid catabolic process (GO:0046395)3.07304494
89negative regulation of protein localization to cell surface (GO:2000009)3.07152781
90regulation of cell communication by electrical coupling (GO:0010649)3.06475409
91striated muscle hypertrophy (GO:0014897)3.05139681
92ubiquinone biosynthetic process (GO:0006744)3.04204589
93quinone biosynthetic process (GO:1901663)3.04204589
94regulation of synapse structural plasticity (GO:0051823)3.03573247
95striated muscle contraction (GO:0006941)3.03544129
96alpha-amino acid catabolic process (GO:1901606)3.02652944
97regulation of triglyceride catabolic process (GO:0010896)3.01338058
98regulation of actin filament-based movement (GO:1903115)3.01075364
99detection of calcium ion (GO:0005513)3.00676331
100bile acid biosynthetic process (GO:0006699)3.00417245
101sulfur amino acid catabolic process (GO:0000098)3.00194382
102pyrimidine nucleobase catabolic process (GO:0006208)2.99138541
103regulation of striated muscle contraction (GO:0006942)2.95779084
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94990014
105regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.93557949
106triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.93159830
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91161464
108indole-containing compound catabolic process (GO:0042436)2.90988160
109indolalkylamine catabolic process (GO:0046218)2.90988160
110tryptophan catabolic process (GO:0006569)2.90988160
111cellular amino acid catabolic process (GO:0009063)2.90845805
112negative regulation of cation channel activity (GO:2001258)2.89764593
113calcium-mediated signaling using intracellular calcium source (GO:0035584)2.89408423
114positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88670200
115ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.86999555
116creatine metabolic process (GO:0006600)2.86679142
117positive regulation of fatty acid oxidation (GO:0046321)2.84959623
118regulation of integrin-mediated signaling pathway (GO:2001044)2.84535174
119aerobic respiration (GO:0009060)2.84303669
120aldehyde catabolic process (GO:0046185)2.83777328
121negative regulation of appetite (GO:0032099)2.83756199
122negative regulation of response to food (GO:0032096)2.83756199
123regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.82690645
124relaxation of muscle (GO:0090075)2.82612456
125acyl-CoA metabolic process (GO:0006637)2.82420052
126platelet dense granule organization (GO:0060155)2.77806596
127regulation of membrane repolarization (GO:0060306)2.77324452
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74709463
129regulation of cilium movement (GO:0003352)2.72043341
130positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.71609197
131amino acid salvage (GO:0043102)2.71293163
132L-methionine salvage (GO:0071267)2.71293163
133L-methionine biosynthetic process (GO:0071265)2.71293163
134relaxation of smooth muscle (GO:0044557)2.59322738
135actin filament-based movement (GO:0030048)2.58221122
136regulation of calcium ion transmembrane transporter activity (GO:1901019)2.55882935
137regulation of calcium ion transmembrane transport (GO:1903169)2.55882935
138positive regulation of action potential (GO:0045760)2.52439862
139nucleobase catabolic process (GO:0046113)2.51964503
140muscle contraction (GO:0006936)2.51353624
141membrane depolarization during action potential (GO:0086010)2.51145907
142muscle hypertrophy (GO:0014896)2.48657262
143positive regulation of mitochondrial fission (GO:0090141)2.48140569
144skeletal muscle contraction (GO:0003009)2.47009049
145positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.45621627
146postsynaptic membrane organization (GO:0001941)2.45415724
147relaxation of cardiac muscle (GO:0055119)2.44613901
148protein polyglutamylation (GO:0018095)2.43276029
149regulation of lipoprotein metabolic process (GO:0050746)2.41621535
150dopamine transport (GO:0015872)2.41427257
151blood coagulation, intrinsic pathway (GO:0007597)2.39547548
152C4-dicarboxylate transport (GO:0015740)2.39477732
153regulation of cardiac muscle contraction (GO:0055117)2.37041068
154xenobiotic catabolic process (GO:0042178)2.36699855
155muscle system process (GO:0003012)2.36538942
156regulation of the force of heart contraction (GO:0002026)2.34268404
157regulation of microtubule-based movement (GO:0060632)2.33690133
158response to inactivity (GO:0014854)2.33669558
159response to epinephrine (GO:0071871)2.31980731
160regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31582611
161muscle fiber development (GO:0048747)2.30297159
162ketone biosynthetic process (GO:0042181)2.29413429
163regulation of heart rate (GO:0002027)2.27485517
164cell communication by electrical coupling (GO:0010644)2.26959159
165muscle tissue morphogenesis (GO:0060415)2.25046064
166retinal cone cell development (GO:0046549)2.23707583
167regulation of ATPase activity (GO:0043462)2.23268333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.97627338
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.81981370
3EZH2_22144423_ChIP-Seq_EOC_Human5.34021639
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.55656688
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.14298319
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.65584523
7GBX2_23144817_ChIP-Seq_PC3_Human3.29511792
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.28838085
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.19611661
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.10405002
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.09912934
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74372615
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.70152627
14VDR_22108803_ChIP-Seq_LS180_Human2.33299049
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31633571
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.17350030
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14777803
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04633845
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04365471
20IGF1R_20145208_ChIP-Seq_DFB_Human1.93968125
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92966713
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91369745
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90149671
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89862960
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84859639
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83050931
27CLOCK_20551151_ChIP-Seq_293T_Human1.82957803
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77804247
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77436954
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.75067121
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.75067121
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74547190
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.70128638
34ZNF274_21170338_ChIP-Seq_K562_Hela1.70056349
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66938101
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62819118
37ZNF263_19887448_ChIP-Seq_K562_Human1.61239725
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59392499
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54688032
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.54629121
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54577315
42TAF15_26573619_Chip-Seq_HEK293_Human1.53154954
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51608354
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51574843
45GATA4_21415370_ChIP-Seq_HL-1_Mouse1.49485026
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46155292
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45107168
48REST_21632747_ChIP-Seq_MESCs_Mouse1.44111077
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42922239
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42287809
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.41196611
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.41052289
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38535836
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38358377
55BCL6_27268052_Chip-Seq_Bcells_Human1.37856861
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34667318
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34494423
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34131374
59DROSHA_22980978_ChIP-Seq_HELA_Human1.33661148
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.33006999
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.32676553
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30446296
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.30206570
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29983518
65SMAD4_21799915_ChIP-Seq_A2780_Human1.29496558
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29321647
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28983151
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27724343
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25594960
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25399064
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25365475
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25252339
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24495716
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24280221
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23922369
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23185316
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.23007290
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.20448325
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20188854
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19404099
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19035140
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16996710
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16959810
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16314161
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14736832
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12326723
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10459154
88TP53_22573176_ChIP-Seq_HFKS_Human1.09454294
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09258474
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.08624838
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08379569
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.07982403
93TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07861995
94AR_25329375_ChIP-Seq_VCAP_Human1.07105008
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06943863
96RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06939894
97P300_19829295_ChIP-Seq_ESCs_Human1.06786877
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06560025
99RNF2_27304074_Chip-Seq_NSC_Mouse1.05993186
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.05636009
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.05606915
102NANOG_19829295_ChIP-Seq_ESCs_Human1.05492478
103SOX2_19829295_ChIP-Seq_ESCs_Human1.05492478
104BCAT_22108803_ChIP-Seq_LS180_Human1.05290559
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03996194
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03202011
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02451030
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02346905
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01163632
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01016601
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00977573
112OCT4_20526341_ChIP-Seq_ESCs_Human1.00474143
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00418391
114ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00049450
115E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97620025
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97574022
117ERG_20517297_ChIP-Seq_VCAP_Human0.97398480
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97104871
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97044603
120TCF4_23295773_ChIP-Seq_U87_Human0.96136340
121BCOR_27268052_Chip-Seq_Bcells_Human0.95211563
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95095898
123STAT3_23295773_ChIP-Seq_U87_Human0.95006199
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.94097422
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93740843
126RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93740843
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93346483
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93015037
129MYC_19829295_ChIP-Seq_ESCs_Human0.92352084
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92315549
131ELF1_20517297_ChIP-Seq_JURKAT_Human0.92160586
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91419183
133GATA1_22025678_ChIP-Seq_K562_Human0.91042029
134NANOG_20526341_ChIP-Seq_ESCs_Human0.91035801
135YY1_21170310_ChIP-Seq_MESCs_Mouse0.90844166
136MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90302376
137GATA3_21878914_ChIP-Seq_MCF-7_Human0.89600376
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89390212
139CBP_20019798_ChIP-Seq_JUKART_Human0.88714369
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88714369
141AR_20517297_ChIP-Seq_VCAP_Human0.88602993
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.87860851
143CTCF_26484167_Chip-Seq_Bcells_Mouse0.87764984
144GABP_19822575_ChIP-Seq_HepG2_Human0.87710944
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87570221
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86625918
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86336884
148AR_21572438_ChIP-Seq_LNCaP_Human0.85404597
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85353062
150RARB_27405468_Chip-Seq_BRAIN_Mouse0.85332582
151TBL1_22424771_ChIP-Seq_293T_Human0.85321731
152CRX_20693478_ChIP-Seq_RETINA_Mouse0.85183220
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85163781
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85160212
155PHF8_20622853_ChIP-Seq_HELA_Human0.84102833
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83881609
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83797281
158SOX2_22085726_ChIP-Seq_NPCs_Mouse0.83579986
159ER_23166858_ChIP-Seq_MCF-7_Human0.83509403
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83123862
161CTCF_27219007_Chip-Seq_Bcells_Human0.82997608
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82242247
163KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82142634
164HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81547058
165E2F1_20622854_ChIP-Seq_HELA_Human0.80155305
166EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80012883
167RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79997436
168ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79798039
169PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79086621
170P68_20966046_ChIP-Seq_HELA_Human0.78640536
171CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78410763
172HTT_18923047_ChIP-ChIP_STHdh_Human0.77194591
173SOX2_21211035_ChIP-Seq_LN229_Human0.76789923
174ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.76548935
175P300_27268052_Chip-Seq_Bcells_Human0.75475727
176RARB_24833708_ChIP-Seq_LIVER_Mouse0.75094512
177SPI1_20517297_ChIP-Seq_HL60_Human0.74807387
178NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74792876
179CTCF_20526341_ChIP-Seq_ESCs_Human0.74769636
180CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74743564
181HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.74556725
182GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72345069
183GATA1_19941827_ChIP-Seq_MEL_Mouse0.71995709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.67508871
2MP0003646_muscle_fatigue4.63043032
3MP0003806_abnormal_nucleotide_metabolis3.91204132
4MP0004084_abnormal_cardiac_muscle3.89076151
5MP0002139_abnormal_hepatobiliary_system3.85142947
6MP0000749_muscle_degeneration3.69826742
7MP0000751_myopathy3.60986809
8MP0004036_abnormal_muscle_relaxation3.35235044
9MP0005360_urolithiasis3.29256994
10MP0005365_abnormal_bile_salt3.06355788
11MP0005085_abnormal_gallbladder_physiolo2.90279378
12MP0005670_abnormal_white_adipose2.84293435
13MP0004215_abnormal_myocardial_fiber2.82590968
14MP0005330_cardiomyopathy2.81042147
15MP0006036_abnormal_mitochondrial_physio2.79669844
16MP0004130_abnormal_muscle_cell2.45678250
17MP0003195_calcinosis2.25796887
18MP0008875_abnormal_xenobiotic_pharmacok2.23063851
19MP0004145_abnormal_muscle_electrophysio2.18758489
20MP0004087_abnormal_muscle_fiber2.16683988
21MP0002269_muscular_atrophy2.10718177
22MP0005451_abnormal_body_composition2.09291280
23MP0002972_abnormal_cardiac_muscle2.08371089
24MP0002102_abnormal_ear_morphology2.06619544
25MP0003880_abnormal_central_pattern1.95388991
26MP0005332_abnormal_amino_acid1.95329062
27MP0005620_abnormal_muscle_contractility1.93554673
28MP0005083_abnormal_biliary_tract1.93122154
29MP0006276_abnormal_autonomic_nervous1.86913699
30MP0000747_muscle_weakness1.82900938
31MP0008775_abnormal_heart_ventricle1.80884293
32MP0003252_abnormal_bile_duct1.80495970
33MP0005385_cardiovascular_system_phenoty1.77020086
34MP0001544_abnormal_cardiovascular_syste1.77020086
35MP0001968_abnormal_touch/_nociception1.76386220
36MP0002822_catalepsy1.72436681
37MP0003137_abnormal_impulse_conducting1.72288196
38MP0010329_abnormal_lipoprotein_level1.72280281
39MP0002106_abnormal_muscle_physiology1.72111001
40MP0003221_abnormal_cardiomyocyte_apopto1.71122746
41MP0005171_absent_coat_pigmentation1.69979869
42MP0000750_abnormal_muscle_regeneration1.67713412
43MP0004142_abnormal_muscle_tone1.65948503
44MP0010630_abnormal_cardiac_muscle1.63936053
45MP0005319_abnormal_enzyme/_coenzyme1.62831313
46MP0003186_abnormal_redox_activity1.62568919
47MP0009046_muscle_twitch1.62549936
48MP0002736_abnormal_nociception_after1.61314871
49MP0004859_abnormal_synaptic_plasticity1.59080416
50MP0005464_abnormal_platelet_physiology1.58635863
51MP0004147_increased_porphyrin_level1.58201386
52MP0009840_abnormal_foam_cell1.54413521
53MP0001529_abnormal_vocalization1.53063250
54MP0006035_abnormal_mitochondrial_morpho1.50394456
55MP0003136_yellow_coat_color1.45986194
56MP0006138_congestive_heart_failure1.45205945
57MP0002638_abnormal_pupillary_reflex1.44846026
58MP0002272_abnormal_nervous_system1.43734445
59MP0009745_abnormal_behavioral_response1.43099518
60MP0005584_abnormal_enzyme/coenzyme_acti1.43003632
61MP0000759_abnormal_skeletal_muscle1.41401493
62MP0009780_abnormal_chondrocyte_physiolo1.40884532
63MP0000372_irregular_coat_pigmentation1.40829684
64MP0002118_abnormal_lipid_homeostasis1.39601203
65MP0005369_muscle_phenotype1.38868598
66MP0000013_abnormal_adipose_tissue1.36524719
67MP0005666_abnormal_adipose_tissue1.34546735
68MP0005423_abnormal_somatic_nervous1.29931396
69MP0005646_abnormal_pituitary_gland1.29276444
70MP0010368_abnormal_lymphatic_system1.28317704
71MP0005551_abnormal_eye_electrophysiolog1.26764286
72MP0000343_altered_response_to1.26656780
73MP0002735_abnormal_chemical_nociception1.26355176
74MP0002733_abnormal_thermal_nociception1.26347802
75MP0002064_seizures1.26025738
76MP0002653_abnormal_ependyma_morphology1.25360305
77MP0004270_analgesia1.23936523
78MP0001970_abnormal_pain_threshold1.23773186
79MP0003635_abnormal_synaptic_transmissio1.23376107
80MP0009697_abnormal_copulation1.23120071
81MP0003191_abnormal_cellular_cholesterol1.22810219
82MP0001486_abnormal_startle_reflex1.22796075
83MP0001986_abnormal_taste_sensitivity1.22410147
84MP0001984_abnormal_olfaction1.21476881
85MP0001764_abnormal_homeostasis1.19328383
86MP0001905_abnormal_dopamine_level1.17242687
87MP0005410_abnormal_fertilization1.17222087
88MP0003656_abnormal_erythrocyte_physiolo1.14880546
89MP0009643_abnormal_urine_homeostasis1.13667026
90MP0004484_altered_response_of1.13039706
91MP0001666_abnormal_nutrient_absorption1.12859166
92MP0004233_abnormal_muscle_weight1.12792189
93MP0003950_abnormal_plasma_membrane1.11270047
94MP0008872_abnormal_physiological_respon1.10476489
95MP0002572_abnormal_emotion/affect_behav1.09887762
96MP0004085_abnormal_heartbeat1.08533164
97MP0003879_abnormal_hair_cell1.08523326
98MP0002734_abnormal_mechanical_nocicepti1.08326059
99MP0000609_abnormal_liver_physiology1.08295694
100MP0004924_abnormal_behavior1.02131713
101MP0005386_behavior/neurological_phenoty1.02131713
102MP0000230_abnormal_systemic_arterial1.00962729
103MP0002127_abnormal_cardiovascular_syste1.00065681
104MP0002063_abnormal_learning/memory/cond0.99609745
105MP0002067_abnormal_sensory_capabilities0.96892381
106MP0004782_abnormal_surfactant_physiolog0.96195468
107MP0005167_abnormal_blood-brain_barrier0.91556781
108MP0004043_abnormal_pH_regulation0.90703107
109MP0008569_lethality_at_weaning0.90505534
110MP0002332_abnormal_exercise_endurance0.89313764
111MP0008004_abnormal_stomach_pH0.89305847
112MP0005253_abnormal_eye_physiology0.88613193
113MP0005165_increased_susceptibility_to0.87290570
114MP0005266_abnormal_metabolism0.86260810
115MP0003828_pulmonary_edema0.82735104
116MP0002557_abnormal_social/conspecific_i0.81915709
117MP0003329_amyloid_beta_deposits0.81169834
118MP0003011_delayed_dark_adaptation0.80919055
119MP0005377_hearing/vestibular/ear_phenot0.78848423
120MP0003878_abnormal_ear_physiology0.78848423
121MP0005636_abnormal_mineral_homeostasis0.78476659
122MP0002078_abnormal_glucose_homeostasis0.78359580
123MP0002876_abnormal_thyroid_physiology0.77960458
124MP0008438_abnormal_cutaneous_collagen0.77870035
125MP0003279_aneurysm0.74549657
126MP0001661_extended_life_span0.72881265
127MP0003122_maternal_imprinting0.72586428
128MP0005084_abnormal_gallbladder_morpholo0.72303430
129MP0001958_emphysema0.71153194
130MP0002066_abnormal_motor_capabilities/c0.70787655
131MP0001502_abnormal_circadian_rhythm0.70013369
132MP0000598_abnormal_liver_morphology0.68248072
133MP0005375_adipose_tissue_phenotype0.68062549
134MP0004885_abnormal_endolymph0.67787899
135MP0009642_abnormal_blood_homeostasis0.65621799
136MP0002971_abnormal_brown_adipose0.65510226
137MP0005058_abnormal_lysosome_morphology0.65079227
138MP0005376_homeostasis/metabolism_phenot0.64929246
139MP0001756_abnormal_urination0.62402671
140MP0000266_abnormal_heart_morphology0.62170424
141MP0005334_abnormal_fat_pad0.60260703
142MP0003567_abnormal_fetal_cardiomyocyte0.59484860
143MP0005647_abnormal_sex_gland0.58367653
144MP0002128_abnormal_blood_circulation0.56281515
145MP0004019_abnormal_vitamin_homeostasis0.53416232
146MP0008469_abnormal_protein_level0.52975948
147MP0005535_abnormal_body_temperature0.52696269
148MP0008260_abnormal_autophagy0.52331865
149MP0000358_abnormal_cell_content/0.51919340
150MP0004510_myositis0.49728299
151MP0005595_abnormal_vascular_smooth0.49637463
152MP0002108_abnormal_muscle_morphology0.49388253
153MP0002295_abnormal_pulmonary_circulatio0.48940652
154MP0009763_increased_sensitivity_to0.45544807
155MP0002089_abnormal_postnatal_growth/wei0.43401351

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.78139140
2Myoglobinuria (HP:0002913)4.51199499
3Sudden death (HP:0001699)4.33417795
4Calf muscle hypertrophy (HP:0008981)4.20346967
5Exercise-induced muscle cramps (HP:0003710)4.18971725
6Muscle hypertrophy of the lower extremities (HP:0008968)3.89539127
7Abnormality of fatty-acid metabolism (HP:0004359)3.84880214
8Palpitations (HP:0001962)3.78557834
9Hepatic necrosis (HP:0002605)3.71095466
10Rhabdomyolysis (HP:0003201)3.65610524
11Abnormality of dicarboxylic acid metabolism (HP:0010995)3.64049108
12Dicarboxylic aciduria (HP:0003215)3.64049108
13Abnormal mitochondria in muscle tissue (HP:0008316)3.63508654
14Ventricular tachycardia (HP:0004756)3.62108325
15Neuroendocrine neoplasm (HP:0100634)3.58339314
16Pheochromocytoma (HP:0002666)3.57425621
17Acute necrotizing encephalopathy (HP:0006965)3.55275428
18Acute encephalopathy (HP:0006846)3.53559911
19Lipoatrophy (HP:0100578)3.50379617
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46071283
21Ketosis (HP:0001946)3.40778007
22Cerebral edema (HP:0002181)3.40776439
23Muscle fiber splitting (HP:0003555)3.37250560
24Hyperammonemia (HP:0001987)3.30375502
25Abnormality of the calf musculature (HP:0001430)3.29309616
26Ketoacidosis (HP:0001993)3.27298770
27Generalized aminoaciduria (HP:0002909)3.27241889
28Asymmetric septal hypertrophy (HP:0001670)3.26352768
29Hepatocellular necrosis (HP:0001404)3.23272305
30Hypoglycemic coma (HP:0001325)3.21823734
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16461062
32Atrial fibrillation (HP:0005110)3.13704188
33Dilated cardiomyopathy (HP:0001644)3.13644246
34Hyperglycinuria (HP:0003108)3.10548172
35Hyporeflexia of lower limbs (HP:0002600)2.99025954
36Increased muscle lipid content (HP:0009058)2.94037861
37Increased serum pyruvate (HP:0003542)2.92901481
38Abnormality of glycolysis (HP:0004366)2.92901481
39Mitochondrial inheritance (HP:0001427)2.90504195
40Frequent falls (HP:0002359)2.89780710
41Primary atrial arrhythmia (HP:0001692)2.89770991
42EMG: myopathic abnormalities (HP:0003458)2.88093626
43Increased CSF lactate (HP:0002490)2.87251855
44Abnormality of serine family amino acid metabolism (HP:0010894)2.86859723
45Abnormality of glycine metabolism (HP:0010895)2.86859723
46Lactic acidosis (HP:0003128)2.86334091
47Supraventricular tachycardia (HP:0004755)2.84037529
48Abnormality of the left ventricular outflow tract (HP:0011103)2.83682554
49Subaortic stenosis (HP:0001682)2.83682554
50Progressive macrocephaly (HP:0004481)2.78532333
51Supraventricular arrhythmia (HP:0005115)2.77849772
52Muscle stiffness (HP:0003552)2.77333207
53Left ventricular hypertrophy (HP:0001712)2.75442421
54Ragged-red muscle fibers (HP:0003200)2.70237115
55Myotonia (HP:0002486)2.69671870
56Lethargy (HP:0001254)2.68261524
57Deep venous thrombosis (HP:0002625)2.63332196
58Renal Fanconi syndrome (HP:0001994)2.62545065
59Metabolic acidosis (HP:0001942)2.62340251
60Distal arthrogryposis (HP:0005684)2.59506311
61Hyperlipoproteinemia (HP:0010980)2.51308988
62Respiratory failure (HP:0002878)2.50481100
63Hyperglycinemia (HP:0002154)2.49117518
64Myopathic facies (HP:0002058)2.47088395
65Prolonged bleeding time (HP:0003010)2.46622885
66Methylmalonic aciduria (HP:0012120)2.46481257
67Neck muscle weakness (HP:0000467)2.44228168
68Neoplasm of the adrenal gland (HP:0100631)2.43382376
69Increased intramyocellular lipid droplets (HP:0012240)2.43248883
70Polyphagia (HP:0002591)2.42362738
71Abnormality of serum amino acid levels (HP:0003112)2.38075734
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37965044
73Abnormality of alanine metabolism (HP:0010916)2.37965044
74Hyperalaninemia (HP:0003348)2.37965044
75Increased connective tissue (HP:0009025)2.37838276
76Abnormal atrioventricular conduction (HP:0005150)2.37186114
77Exercise intolerance (HP:0003546)2.35099565
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34138537
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34138537
80Vomiting (HP:0002013)2.32449974
81Xanthomatosis (HP:0000991)2.31095996
82Cerebral hemorrhage (HP:0001342)2.30491974
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.30469973
84Muscle fiber inclusion bodies (HP:0100299)2.29790430
85Menorrhagia (HP:0000132)2.28765142
86Hypobetalipoproteinemia (HP:0003563)2.24046285
87Petechiae (HP:0000967)2.23997838
88Abnormal EKG (HP:0003115)2.23271083
89Atonic seizures (HP:0010819)2.22922334
90Conjunctival hamartoma (HP:0100780)2.22298478
91Intrahepatic cholestasis (HP:0001406)2.21657910
92Ventricular fibrillation (HP:0001663)2.21164988
93Nausea (HP:0002018)2.20018424
94Right ventricular cardiomyopathy (HP:0011663)2.19450496
95Late onset (HP:0003584)2.19040588
96Proximal tubulopathy (HP:0000114)2.18815649
97Lipid accumulation in hepatocytes (HP:0006561)2.16340194
98Atrioventricular block (HP:0001678)2.15877837
99Hypoalphalipoproteinemia (HP:0003233)2.14795758
100Heart block (HP:0012722)2.14604250
101Increased serum lactate (HP:0002151)2.13425550
102Gout (HP:0001997)2.12788456
103Ventricular arrhythmia (HP:0004308)2.11604219
104Purpura (HP:0000979)2.09780322
105Rimmed vacuoles (HP:0003805)2.09417832
106Gait imbalance (HP:0002141)2.09386572
107Hypolipoproteinemia (HP:0010981)2.09340932
108Syncope (HP:0001279)2.08619758
109Bundle branch block (HP:0011710)2.08618504
110Hemiparesis (HP:0001269)2.08547792
111Medial flaring of the eyebrow (HP:0010747)2.08313237
112Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08252563
113Type 1 muscle fiber predominance (HP:0003803)2.08098044
114Nemaline bodies (HP:0003798)2.07994342
115Round ear (HP:0100830)2.06063041
116Abnormal pupillary function (HP:0007686)2.03824517
117Prolonged QT interval (HP:0001657)2.03288433
118EMG: neuropathic changes (HP:0003445)2.02304951
119Focal motor seizures (HP:0011153)2.01520353
120Glycosuria (HP:0003076)2.00382761
121Abnormality of urine glucose concentration (HP:0011016)2.00382761
122Neoplasm of head and neck (HP:0012288)1.98632809
123Esophageal neoplasm (HP:0100751)1.98632809
124Neoplasm of the peripheral nervous system (HP:0100007)1.97177534
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.95636664
126Myokymia (HP:0002411)1.92177747
127Oligomenorrhea (HP:0000876)1.89479054
128Abnormality of skeletal muscle fiber size (HP:0012084)1.89017822
129Type 2 muscle fiber atrophy (HP:0003554)1.86558060
130Areflexia of lower limbs (HP:0002522)1.85808445
131Congenital stationary night blindness (HP:0007642)1.83480213
132Congenital primary aphakia (HP:0007707)1.82544767
133Generalized muscle weakness (HP:0003324)1.78942298
134Weak cry (HP:0001612)1.78043336
135Distal lower limb muscle weakness (HP:0009053)1.77051735
136Abnormality of lateral ventricle (HP:0030047)1.76683233
137Increased mean platelet volume (HP:0011877)1.75031208
138Febrile seizures (HP:0002373)1.74150013
139Increased variability in muscle fiber diameter (HP:0003557)1.73118291
140Absent phalangeal crease (HP:0006109)1.71564436
141Attenuation of retinal blood vessels (HP:0007843)1.68659151
142Increased hepatocellular lipid droplets (HP:0006565)1.67886493
143Respiratory insufficiency due to muscle weakness (HP:0002747)1.67835077
144Tongue fasciculations (HP:0001308)1.67684308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.87249639
2OBSCN4.14626389
3PDK44.14330572
4PDK34.14330572
5MYLK4.05683071
6TRIB33.55971614
7PHKG13.04673770
8PHKG23.04673770
9TTN2.94597320
10MARK12.76080350
11MKNK22.56703893
12MUSK2.41890323
13LMTK22.35872285
14MAP4K22.31010953
15PKN22.27056973
16PDK22.25910349
17PINK12.04876311
18TIE12.01678206
19TNIK2.01259513
20STK241.97715083
21MAPK131.96951429
22DAPK21.92531146
23PIK3CA1.90081226
24TESK11.67644562
25FRK1.62293931
26STK161.57083044
27ILK1.52747499
28MAPKAPK31.48938602
29MKNK11.47391317
30MAP3K41.40882042
31PLK21.37972282
32ERN11.36158772
33ADRBK21.34957736
34PAK61.32228991
35GRK11.29501791
36GRK51.27536047
37STK38L1.24241698
38PIK3CG1.18919300
39KDR1.16992987
40PKN11.16355086
41TRIM281.13107947
42LIMK11.12919041
43EPHA41.12735771
44CSNK1G21.12664740
45MAP3K121.12251131
46NTRK31.10864655
47NEK11.06685878
48WNK41.05192951
49CSNK1G31.02534923
50FGFR41.02018444
51MAP2K30.96110652
52CAMK2A0.95416635
53PRKCE0.93514269
54ADRBK10.92161591
55BMPR1B0.91902575
56MAPK150.90822105
57FLT30.89980711
58PRKD30.89962902
59SIK10.89332666
60MAPK120.84380707
61SIK30.83192369
62ERBB30.82688881
63KSR10.82526813
64TGFBR10.80382809
65TGFBR20.76522096
66TNK20.75788490
67RIPK10.75179202
68PRKCG0.74172923
69MAP2K60.73003005
70MINK10.72806465
71NTRK20.72201359
72TLK10.71706084
73CSNK1G10.71691648
74TAOK30.70170492
75BMX0.69448196
76MAPKAPK50.66913564
77WNK30.66146874
78DAPK30.62796019
79PAK30.61636673
80CSNK1A1L0.61548952
81FER0.60970335
82EPHB20.60857367
83DMPK0.60320030
84PRKG10.59964508
85CAMK2G0.59898359
86ZAP700.59336325
87CAMK2B0.59029956
88NEK90.58935614
89MAP3K70.58870016
90CCNB10.58535125
91CDK50.58191555
92ARAF0.57504538
93ROCK10.57322102
94MARK30.56931364
95TBK10.55917638
96PRKAA10.55569502
97EIF2AK10.54602854
98INSRR0.52583278
99ACVR1B0.52114553
100NUAK10.51125485
101PRKD10.51108975
102PIM20.50969534
103PRKAA20.50532087
104DYRK20.50208210
105PRKACB0.49776565
106PRKG20.48877258
107MAPK110.47842110
108DYRK1B0.46745403
109ZAK0.46496396
110CAMK2D0.45664914
111DYRK1A0.44665156
112MAP2K70.43914966
113UHMK10.43812826
114MAP3K30.42692309
115STK380.42685942
116NME20.42544565
117PNCK0.42156093
118SYK0.39362748
119PRKCZ0.39274858
120PRKCA0.38934546
121SGK4940.37167720
122SGK2230.37167720
123MAPK40.36821632
124PRKACG0.36387679
125TAOK20.35536311
126KIT0.34095493
127EPHB10.33928077
128LRRK20.32939507
129CAMK40.32352590
130GRK70.32336715
131MAP3K50.32020753
132EPHA30.29687706
133MAP2K40.29665809
134ABL20.27738923
135TRPM70.26514652
136MAP3K110.26302493
137SGK20.26234842
138PRKACA0.25879764
139SGK30.24750701
140MAP2K10.23668546
141PRPF4B0.23112336
142PTK60.21932794
143CAMK10.21850909
144NME10.19709572
145PDPK10.19408961
146BUB10.18657002
147PTK2B0.17920826
148TESK20.17801866
149RPS6KA20.16703367
150ICK0.16019408

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.42624981
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.59399298
3Propanoate metabolism_Homo sapiens_hsa006403.55536163
4Fatty acid degradation_Homo sapiens_hsa000713.37335528
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00699162
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.85692754
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71272613
8Fatty acid metabolism_Homo sapiens_hsa012122.64065657
9Pyruvate metabolism_Homo sapiens_hsa006202.57523790
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56755862
11Carbon metabolism_Homo sapiens_hsa012002.47116031
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.23298948
13Parkinsons disease_Homo sapiens_hsa050122.09630911
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07937896
15Butanoate metabolism_Homo sapiens_hsa006502.04280953
16Oxidative phosphorylation_Homo sapiens_hsa001902.00680717
17Fatty acid elongation_Homo sapiens_hsa000621.99143686
18Peroxisome_Homo sapiens_hsa041461.96095575
19Cardiac muscle contraction_Homo sapiens_hsa042601.84270088
20Tryptophan metabolism_Homo sapiens_hsa003801.84205353
21PPAR signaling pathway_Homo sapiens_hsa033201.83797514
22beta-Alanine metabolism_Homo sapiens_hsa004101.76504738
23Biosynthesis of amino acids_Homo sapiens_hsa012301.71644090
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68956104
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68929767
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55259304
27Arginine biosynthesis_Homo sapiens_hsa002201.54205697
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42371763
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40363183
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40052589
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37417848
32Phototransduction_Homo sapiens_hsa047441.35188162
33Collecting duct acid secretion_Homo sapiens_hsa049661.33745322
34GABAergic synapse_Homo sapiens_hsa047271.31831299
35Caffeine metabolism_Homo sapiens_hsa002321.31238807
36Synaptic vesicle cycle_Homo sapiens_hsa047211.29795379
37Huntingtons disease_Homo sapiens_hsa050161.27285125
38Circadian entrainment_Homo sapiens_hsa047131.27140711
39Arginine and proline metabolism_Homo sapiens_hsa003301.25406242
40Alzheimers disease_Homo sapiens_hsa050101.24253361
41Morphine addiction_Homo sapiens_hsa050321.21026986
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19212649
43Selenocompound metabolism_Homo sapiens_hsa004501.19047170
44Circadian rhythm_Homo sapiens_hsa047101.18579952
45Nitrogen metabolism_Homo sapiens_hsa009101.18495698
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17517943
47Insulin secretion_Homo sapiens_hsa049111.15388744
48Complement and coagulation cascades_Homo sapiens_hsa046101.13516111
49Starch and sucrose metabolism_Homo sapiens_hsa005001.12758362
50Calcium signaling pathway_Homo sapiens_hsa040201.12712950
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12615607
52Nicotine addiction_Homo sapiens_hsa050331.10422261
53Dilated cardiomyopathy_Homo sapiens_hsa054141.10045421
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09923599
55Pentose phosphate pathway_Homo sapiens_hsa000301.08563855
56Sulfur metabolism_Homo sapiens_hsa009201.04677081
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04006852
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02672493
59Sulfur relay system_Homo sapiens_hsa041221.01824597
60Chemical carcinogenesis_Homo sapiens_hsa052041.00966835
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99766236
62Folate biosynthesis_Homo sapiens_hsa007900.98181337
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.97918196
64Histidine metabolism_Homo sapiens_hsa003400.97759820
65Phenylalanine metabolism_Homo sapiens_hsa003600.97267510
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96206200
67Tyrosine metabolism_Homo sapiens_hsa003500.93436341
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.92203907
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90514923
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88119180
71Serotonergic synapse_Homo sapiens_hsa047260.86526529
72Proteasome_Homo sapiens_hsa030500.84736769
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83645258
74Glutamatergic synapse_Homo sapiens_hsa047240.83235003
75Taste transduction_Homo sapiens_hsa047420.82497279
76Amphetamine addiction_Homo sapiens_hsa050310.82320221
77Oxytocin signaling pathway_Homo sapiens_hsa049210.81842593
78Cocaine addiction_Homo sapiens_hsa050300.79264664
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78351800
80Metabolic pathways_Homo sapiens_hsa011000.76585166
81Platelet activation_Homo sapiens_hsa046110.75242193
82Glutathione metabolism_Homo sapiens_hsa004800.75064264
83Fructose and mannose metabolism_Homo sapiens_hsa000510.74939999
84Bile secretion_Homo sapiens_hsa049760.73438229
85Dopaminergic synapse_Homo sapiens_hsa047280.72899413
86Regulation of autophagy_Homo sapiens_hsa041400.69456135
87Gastric acid secretion_Homo sapiens_hsa049710.68667337
88Renin secretion_Homo sapiens_hsa049240.68664880
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.67453462
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67228732
91Fatty acid biosynthesis_Homo sapiens_hsa000610.67196927
92Olfactory transduction_Homo sapiens_hsa047400.66024954
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65519323
94Fat digestion and absorption_Homo sapiens_hsa049750.65050877
95Glycerolipid metabolism_Homo sapiens_hsa005610.64533876
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.64472824
97Galactose metabolism_Homo sapiens_hsa000520.64333437
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63305168
99Salivary secretion_Homo sapiens_hsa049700.62060492
100Glucagon signaling pathway_Homo sapiens_hsa049220.57589008
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56707749
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55647350
103Lysine degradation_Homo sapiens_hsa003100.54546132
104Vitamin B6 metabolism_Homo sapiens_hsa007500.50771232
105Cholinergic synapse_Homo sapiens_hsa047250.50698022
106cAMP signaling pathway_Homo sapiens_hsa040240.47935121
107Gap junction_Homo sapiens_hsa045400.47323684
108ABC transporters_Homo sapiens_hsa020100.47121916
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43777457
110Insulin resistance_Homo sapiens_hsa049310.43364947
111Insulin signaling pathway_Homo sapiens_hsa049100.40758004
112Retinol metabolism_Homo sapiens_hsa008300.38890321
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.36852064
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36279519
115Vitamin digestion and absorption_Homo sapiens_hsa049770.31285857
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.30693088
117Protein export_Homo sapiens_hsa030600.29022019
118AMPK signaling pathway_Homo sapiens_hsa041520.28781161
119Staphylococcus aureus infection_Homo sapiens_hsa051500.25995765
120Viral myocarditis_Homo sapiens_hsa054160.25724837
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24410985
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23756686
123Steroid biosynthesis_Homo sapiens_hsa001000.20841384
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20829389
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.19352808
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15419973
127Purine metabolism_Homo sapiens_hsa002300.15115722
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11968638
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11158815
130Linoleic acid metabolism_Homo sapiens_hsa005910.07430124
131Arachidonic acid metabolism_Homo sapiens_hsa005900.06480041
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.06168004
133Ovarian steroidogenesis_Homo sapiens_hsa049130.05675715
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05551459

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