MTFR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)4.89914465
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.83887556
3pore complex assembly (GO:0046931)4.49451219
4mitotic sister chromatid segregation (GO:0000070)4.31804674
5sister chromatid segregation (GO:0000819)4.16289193
6glycine metabolic process (GO:0006544)4.15848938
7ribosome assembly (GO:0042255)4.04842176
8mitotic sister chromatid cohesion (GO:0007064)4.03163849
9cysteine metabolic process (GO:0006534)3.92320514
10metaphase plate congression (GO:0051310)3.89310232
11Golgi transport vesicle coating (GO:0048200)3.88175340
12COPI coating of Golgi vesicle (GO:0048205)3.88175340
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.85830395
14L-phenylalanine metabolic process (GO:0006558)3.85830395
15aromatic amino acid family catabolic process (GO:0009074)3.81292848
16serine family amino acid biosynthetic process (GO:0009070)3.79560713
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78290923
18L-phenylalanine catabolic process (GO:0006559)3.78290923
19indole-containing compound catabolic process (GO:0042436)3.78193901
20indolalkylamine catabolic process (GO:0046218)3.78193901
21tryptophan catabolic process (GO:0006569)3.78193901
22kynurenine metabolic process (GO:0070189)3.76140051
23folic acid metabolic process (GO:0046655)3.75160298
24regulation of centriole replication (GO:0046599)3.74249834
25serine family amino acid catabolic process (GO:0009071)3.72908395
26serine family amino acid metabolic process (GO:0009069)3.68426026
27tryptophan metabolic process (GO:0006568)3.61958241
28sulfur amino acid catabolic process (GO:0000098)3.61799019
29folic acid-containing compound biosynthetic process (GO:0009396)3.60704718
30glyoxylate metabolic process (GO:0046487)3.59702324
31establishment of integrated proviral latency (GO:0075713)3.57642749
32lysine metabolic process (GO:0006553)3.56308322
33lysine catabolic process (GO:0006554)3.56308322
34positive regulation of chromosome segregation (GO:0051984)3.50834452
35chromosome condensation (GO:0030261)3.48185993
36regulation of translational fidelity (GO:0006450)3.44555748
37regulation of mitotic spindle organization (GO:0060236)3.44026938
38regulation of RNA export from nucleus (GO:0046831)3.42197363
39establishment of chromosome localization (GO:0051303)3.41997556
40homocysteine metabolic process (GO:0050667)3.36296712
41regulation of spindle organization (GO:0090224)3.31465718
42amino-acid betaine metabolic process (GO:0006577)3.30740070
43regulation of chromosome segregation (GO:0051983)3.29721852
44tetrahydrofolate metabolic process (GO:0046653)3.26909703
45negative regulation of DNA repair (GO:0045738)3.26248137
46protein complex localization (GO:0031503)3.22611368
47CENP-A containing nucleosome assembly (GO:0034080)3.16878693
48urea metabolic process (GO:0019627)3.14781524
49urea cycle (GO:0000050)3.14781524
50telomere maintenance via semi-conservative replication (GO:0032201)3.12414783
51cellular protein complex localization (GO:0034629)3.11363485
52DNA packaging (GO:0006323)3.10803004
53heterochromatin organization (GO:0070828)3.09744464
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.08423880
55negative regulation of fibrinolysis (GO:0051918)3.06355209
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.04691060
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04691060
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04691060
59non-recombinational repair (GO:0000726)3.04675630
60double-strand break repair via nonhomologous end joining (GO:0006303)3.04675630
61purine nucleobase biosynthetic process (GO:0009113)3.03799587
62bile acid biosynthetic process (GO:0006699)3.02654426
63nucleobase biosynthetic process (GO:0046112)3.02240714
64spindle checkpoint (GO:0031577)3.01825508
65nucleobase-containing small molecule interconversion (GO:0015949)3.01070956
66regulation of centrosome cycle (GO:0046605)3.00734472
67chromatin remodeling at centromere (GO:0031055)3.00120751
68folic acid-containing compound metabolic process (GO:0006760)3.00053668
69negative regulation of fatty acid biosynthetic process (GO:0045717)2.99232914
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.97653131
71regulation of sister chromatid cohesion (GO:0007063)2.96630690
72chromosome segregation (GO:0007059)2.96501832
73alpha-linolenic acid metabolic process (GO:0036109)2.94127148
74L-serine metabolic process (GO:0006563)2.94017892
75urate metabolic process (GO:0046415)2.93295225
76one-carbon metabolic process (GO:0006730)2.93007714
77aromatic amino acid family metabolic process (GO:0009072)2.92094929
78nitrogen cycle metabolic process (GO:0071941)2.88581745
79mitotic spindle checkpoint (GO:0071174)2.87801719
80DNA topological change (GO:0006265)2.85912013
81DNA replication-dependent nucleosome assembly (GO:0006335)2.84480879
82DNA replication-dependent nucleosome organization (GO:0034723)2.84480879
83regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82108764
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82108764
85alpha-amino acid catabolic process (GO:1901606)2.81572039
86protein localization to chromosome (GO:0034502)2.80924958
87protein carboxylation (GO:0018214)2.80737864
88peptidyl-glutamic acid carboxylation (GO:0017187)2.80737864
89negative regulation of chromosome segregation (GO:0051985)2.80512572
90DNA duplex unwinding (GO:0032508)2.80289915
91COPII vesicle coating (GO:0048208)2.78370112
92nuclear envelope organization (GO:0006998)2.78266836
93mitotic recombination (GO:0006312)2.78057715
94telomere maintenance via recombination (GO:0000722)2.77861359
95DNA conformation change (GO:0071103)2.77595908
96kinetochore organization (GO:0051383)2.77376854
97protoporphyrinogen IX metabolic process (GO:0046501)2.75753034
98formation of translation preinitiation complex (GO:0001731)2.73963361
99regulation of mitotic sister chromatid separation (GO:0010965)2.73642217
100regulation of mitotic sister chromatid segregation (GO:0033047)2.73642217
101regulation of sister chromatid segregation (GO:0033045)2.73642217
102regulation of protein activation cascade (GO:2000257)2.73389528
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72620779
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71971816
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.71971816
106negative regulation of sister chromatid segregation (GO:0033046)2.71971816
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71971816
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71971816
109imidazole-containing compound metabolic process (GO:0052803)2.71189197
110DNA ligation (GO:0006266)2.70834944
111regulation of nucleobase-containing compound transport (GO:0032239)2.70723690
112nuclear pore organization (GO:0006999)2.70661565
113DNA geometric change (GO:0032392)2.70473450
114nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.70295933
115protein localization to kinetochore (GO:0034501)2.70213464
116regulation of fibrinolysis (GO:0051917)2.69221714
117mitotic spindle assembly checkpoint (GO:0007094)2.68776217
118pteridine-containing compound biosynthetic process (GO:0042559)2.66051155
119spindle assembly checkpoint (GO:0071173)2.64419254
120DNA deamination (GO:0045006)2.63898806
121cellular amino acid catabolic process (GO:0009063)2.63861063
122tRNA aminoacylation for protein translation (GO:0006418)2.63728778
123carnitine metabolic process (GO:0009437)2.63088877
124paraxial mesoderm development (GO:0048339)2.61565033
125histone exchange (GO:0043486)2.61299379
126drug transmembrane transport (GO:0006855)2.61149073
127protoporphyrinogen IX biosynthetic process (GO:0006782)2.60901755
128pteridine-containing compound metabolic process (GO:0042558)2.60901213
129mitotic nuclear envelope disassembly (GO:0007077)2.60897512
130regulation of centrosome duplication (GO:0010824)2.60733726
131DNA replication initiation (GO:0006270)2.60125074
132indolalkylamine metabolic process (GO:0006586)2.58997193
133valine metabolic process (GO:0006573)2.58211188
134sulfur amino acid biosynthetic process (GO:0000097)2.57640126
135high-density lipoprotein particle remodeling (GO:0034375)2.57179413
136DNA replication-independent nucleosome organization (GO:0034724)2.57099120
137DNA replication-independent nucleosome assembly (GO:0006336)2.57099120
138protein localization to chromosome, centromeric region (GO:0071459)2.56562353
139regulation of complement activation (GO:0030449)2.56403355
140tRNA aminoacylation (GO:0043039)2.56129983
141amino acid activation (GO:0043038)2.56129983
142cellular modified amino acid catabolic process (GO:0042219)2.55963138
143DNA replication checkpoint (GO:0000076)2.55771619
144establishment of viral latency (GO:0019043)2.55771128
145nuclear pore complex assembly (GO:0051292)2.54986398
146bile acid metabolic process (GO:0008206)2.54856289
147regulation of triglyceride catabolic process (GO:0010896)2.54827575
148DNA strand elongation involved in DNA replication (GO:0006271)2.54373443
149DNA unwinding involved in DNA replication (GO:0006268)2.53730083
150proline biosynthetic process (GO:0006561)2.52866308
151heme transport (GO:0015886)2.52010149
152IMP biosynthetic process (GO:0006188)2.50712078
153nucleoside salvage (GO:0043174)2.49680922
154proline metabolic process (GO:0006560)2.49246851
155attachment of spindle microtubules to kinetochore (GO:0008608)2.49009996
156protein export from nucleus (GO:0006611)2.48568561
157chaperone-mediated protein complex assembly (GO:0051131)2.47869443
158complement activation, alternative pathway (GO:0006957)2.47284847
159cellular glucuronidation (GO:0052695)2.47067509
160cellular biogenic amine catabolic process (GO:0042402)2.46814334
161amine catabolic process (GO:0009310)2.46814334
162ethanol oxidation (GO:0006069)2.46532499
163DNA synthesis involved in DNA repair (GO:0000731)2.46465955
164benzene-containing compound metabolic process (GO:0042537)2.46265933
165ATP-dependent chromatin remodeling (GO:0043044)2.46084545
166acylglycerol homeostasis (GO:0055090)2.45674412
167triglyceride homeostasis (GO:0070328)2.45674412
168aspartate family amino acid catabolic process (GO:0009068)2.44670205
169spindle assembly involved in mitosis (GO:0090307)2.41975304
170mitotic metaphase plate congression (GO:0007080)2.41818336
171coenzyme catabolic process (GO:0009109)2.41634293
172mitotic spindle organization (GO:0007052)2.41477219
173DNA strand elongation (GO:0022616)2.41476710
174nucleotide-sugar biosynthetic process (GO:0009226)2.41397646
175sulfur amino acid metabolic process (GO:0000096)2.41230662
176tyrosine metabolic process (GO:0006570)2.39683652
177mitotic cytokinesis (GO:0000281)2.38844390
178nuclear envelope disassembly (GO:0051081)2.38250025
179membrane disassembly (GO:0030397)2.38250025
180bile acid and bile salt transport (GO:0015721)2.37885322
181ribosome biogenesis (GO:0042254)2.35072896
182organic cation transport (GO:0015695)2.34719125
183drug transport (GO:0015893)2.34664168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.78854663
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.60660804
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20493101
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.13847800
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.11361613
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97104102
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85565090
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.76878876
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.61527619
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.54755375
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48274913
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43428101
13PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.40708012
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.25204443
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.20660796
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20078473
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19789865
18AR_21909140_ChIP-Seq_LNCAP_Human2.15691676
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.14635961
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13086464
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03921531
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02331024
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00176389
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95517173
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90923720
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.89765895
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.85378998
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83476716
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80632182
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78374880
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.77429497
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74208698
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73619229
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70132069
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68265345
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66385917
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62893149
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62821705
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59915032
40* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59630152
41XRN2_22483619_ChIP-Seq_HELA_Human1.55045486
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48438626
43DCP1A_22483619_ChIP-Seq_HELA_Human1.46034109
44VDR_23849224_ChIP-Seq_CD4+_Human1.45921229
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45089993
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43933431
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40642773
48SOX17_20123909_ChIP-Seq_XEN_Mouse1.39107376
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38889862
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38718163
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38256260
52GABP_19822575_ChIP-Seq_HepG2_Human1.37664849
53CHD1_26751641_Chip-Seq_LNCaP_Human1.37643798
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35176691
55FOXP3_21729870_ChIP-Seq_TREG_Human1.34245028
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32257852
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.30843351
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28960986
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27908770
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24484975
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21478231
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.19622550
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14447994
64* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13869090
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12946142
66KDM5A_27292631_Chip-Seq_BREAST_Human1.12238808
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.11761109
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11084401
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10957981
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10746993
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10500167
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10381351
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10089884
74* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09852407
75* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09433129
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08974920
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07580183
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07247713
79* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05996036
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04299205
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03938556
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02671376
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02671376
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02432353
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02327963
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02005505
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02005505
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02005505
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00857515
90TTF2_22483619_ChIP-Seq_HELA_Human1.00839488
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00490315
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00274754
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99764749
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98332859
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97346056
96MYC_22102868_ChIP-Seq_BL_Human0.95628608
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94236510
98ATF3_27146783_Chip-Seq_COLON_Human0.94085865
99* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93955721
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91947671
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91677244
102YY1_21170310_ChIP-Seq_MESCs_Mouse0.91550077
103TP63_17297297_ChIP-ChIP_HaCaT_Human0.91213335
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90866808
105* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90273597
106* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89932232
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89803247
108* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89744009
109ELK1_19687146_ChIP-ChIP_HELA_Human0.89737519
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89678983
111GATA6_25053715_ChIP-Seq_YYC3_Human0.89630741
112ELF5_23300383_ChIP-Seq_T47D_Human0.89471455
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89397704
114GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89280623
115TFEB_21752829_ChIP-Seq_HELA_Human0.87311396
116ZNF263_19887448_ChIP-Seq_K562_Human0.87135982
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85953099
118* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85402108
119* NANOG_21062744_ChIP-ChIP_HESCs_Human0.85241561
120THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84415004
121TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84246910
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84186775
123RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83920873
124* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82943866
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82676018
126* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80889533
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80746755
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80655194
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.80570890
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.79384138
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79371450
132NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79113972
133CLOCK_20551151_ChIP-Seq_293T_Human0.78956176
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78424097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.25788180
2MP0005360_urolithiasis4.37494485
3MP0003806_abnormal_nucleotide_metabolis4.22668266
4MP0005085_abnormal_gallbladder_physiolo3.77825585
5MP0005365_abnormal_bile_salt3.62013589
6MP0010234_abnormal_vibrissa_follicle2.98647658
7MP0008875_abnormal_xenobiotic_pharmacok2.69708045
8MP0002877_abnormal_melanocyte_morpholog2.66571781
9MP0003693_abnormal_embryo_hatching2.59940355
10MP0003011_delayed_dark_adaptation2.51808831
11MP0004957_abnormal_blastocyst_morpholog2.25816275
12MP0003252_abnormal_bile_duct2.21885169
13MP0004233_abnormal_muscle_weight2.14218880
14MP0010094_abnormal_chromosome_stability2.04581742
15MP0003111_abnormal_nucleus_morphology2.00418440
16MP0009840_abnormal_foam_cell1.97500018
17MP0003950_abnormal_plasma_membrane1.95227028
18MP0005083_abnormal_biliary_tract1.91792519
19MP0003705_abnormal_hypodermis_morpholog1.83829719
20MP0003656_abnormal_erythrocyte_physiolo1.82334472
21MP0005332_abnormal_amino_acid1.79498030
22MP0003186_abnormal_redox_activity1.77061250
23MP0003077_abnormal_cell_cycle1.76821490
24MP0010329_abnormal_lipoprotein_level1.72904205
25MP0010352_gastrointestinal_tract_polyps1.72040866
26MP0004019_abnormal_vitamin_homeostasis1.70081345
27MP0001666_abnormal_nutrient_absorption1.66035488
28MP0004272_abnormal_basement_membrane1.51768567
29MP0001764_abnormal_homeostasis1.48203953
30MP0000609_abnormal_liver_physiology1.47873473
31MP0002138_abnormal_hepatobiliary_system1.47739808
32MP0005076_abnormal_cell_differentiation1.46714737
33MP0001661_extended_life_span1.45770086
34MP0004185_abnormal_adipocyte_glucose1.45187748
35MP0003195_calcinosis1.43966366
36MP0008057_abnormal_DNA_replication1.43680643
37MP0005319_abnormal_enzyme/_coenzyme1.39082578
38MP0008058_abnormal_DNA_repair1.38618441
39MP0005410_abnormal_fertilization1.36931349
40MP0003191_abnormal_cellular_cholesterol1.31737171
41MP0004264_abnormal_extraembryonic_tissu1.27204044
42MP0002697_abnormal_eye_size1.26688766
43MP0002009_preneoplasia1.26238959
44MP0003453_abnormal_keratinocyte_physiol1.19644742
45MP0000537_abnormal_urethra_morphology1.19317160
46MP0008007_abnormal_cellular_replicative1.18888614
47MP0001730_embryonic_growth_arrest1.18677214
48MP0005670_abnormal_white_adipose1.14823484
49MP0010678_abnormal_skin_adnexa1.14816682
50MP0003718_maternal_effect1.13562784
51MP0009643_abnormal_urine_homeostasis1.13428306
52MP0003937_abnormal_limbs/digits/tail_de1.11817085
53MP0005623_abnormal_meninges_morphology1.10854080
54MP0000762_abnormal_tongue_morphology1.09967723
55MP0008932_abnormal_embryonic_tissue1.06001843
56MP0002234_abnormal_pharynx_morphology1.05699454
57MP0009697_abnormal_copulation1.05421474
58MP0000598_abnormal_liver_morphology1.04814140
59MP0005380_embryogenesis_phenotype1.04273108
60MP0001672_abnormal_embryogenesis/_devel1.04273108
61MP0008438_abnormal_cutaneous_collagen1.03837901
62MP0000627_abnormal_mammary_gland1.02906581
63MP0003221_abnormal_cardiomyocyte_apopto1.02465954
64MP0005451_abnormal_body_composition1.00521598
65MP0008260_abnormal_autophagy0.99035913
66MP0004147_increased_porphyrin_level0.98731848
67MP0003984_embryonic_growth_retardation0.97988482
68MP0000350_abnormal_cell_proliferation0.97628176
69MP0002088_abnormal_embryonic_growth/wei0.97244072
70MP0002118_abnormal_lipid_homeostasis0.96861106
71MP0001216_abnormal_epidermal_layer0.96072856
72MP0003890_abnormal_embryonic-extraembry0.95791283
73MP0005023_abnormal_wound_healing0.94516650
74MP0005636_abnormal_mineral_homeostasis0.93085460
75MP0006036_abnormal_mitochondrial_physio0.92701007
76MP0005621_abnormal_cell_physiology0.90855633
77MP0001929_abnormal_gametogenesis0.90063377
78MP0009053_abnormal_anal_canal0.89947390
79MP0003868_abnormal_feces_composition0.88382514
80MP0005266_abnormal_metabolism0.88311623
81MP0002092_abnormal_eye_morphology0.88130450
82MP0002269_muscular_atrophy0.87751588
83MP0000428_abnormal_craniofacial_morphol0.86929566
84MP0002653_abnormal_ependyma_morphology0.86691861
85MP0005408_hypopigmentation0.86670848
86MP0009703_decreased_birth_body0.85480629
87MP0010307_abnormal_tumor_latency0.85385230
88MP0001881_abnormal_mammary_gland0.84703207
89MP0005384_cellular_phenotype0.83884479
90MP0001697_abnormal_embryo_size0.83506020
91MP0003786_premature_aging0.83328666
92MP0002086_abnormal_extraembryonic_tissu0.83328541
93MP0010030_abnormal_orbit_morphology0.82880702
94MP0000377_abnormal_hair_follicle0.82200278
95MP0004782_abnormal_surfactant_physiolog0.81821127
96MP0002080_prenatal_lethality0.80983923
97MP0004197_abnormal_fetal_growth/weight/0.79436402
98MP0002019_abnormal_tumor_incidence0.79431547
99MP0005501_abnormal_skin_physiology0.78838912
100MP0000467_abnormal_esophagus_morphology0.78509475
101MP0002396_abnormal_hematopoietic_system0.78223018
102MP0000490_abnormal_crypts_of0.77258281
103MP0005647_abnormal_sex_gland0.77150484
104MP0002132_abnormal_respiratory_system0.76372016
105MP0002796_impaired_skin_barrier0.76354792
106MP0006035_abnormal_mitochondrial_morpho0.75905301
107MP0009672_abnormal_birth_weight0.75881098
108MP0000579_abnormal_nail_morphology0.75846748
109MP0000733_abnormal_muscle_development0.75121410
110MP0003385_abnormal_body_wall0.75109065
111MP0003755_abnormal_palate_morphology0.74959728
112MP0002098_abnormal_vibrissa_morphology0.74516130
113MP0005257_abnormal_intraocular_pressure0.74267376
114MP0003699_abnormal_female_reproductive0.73741019
115MP0005075_abnormal_melanosome_morpholog0.73014253
116MP0001145_abnormal_male_reproductive0.72821196
117MP0002210_abnormal_sex_determination0.71137692
118MP0001286_abnormal_eye_development0.71086901
119MP0002111_abnormal_tail_morphology0.70862337
120MP0000358_abnormal_cell_content/0.69894760
121MP0003315_abnormal_perineum_morphology0.69778627
122MP0005584_abnormal_enzyme/coenzyme_acti0.68576086
123MP0003935_abnormal_craniofacial_develop0.68552138
124MP0005220_abnormal_exocrine_pancreas0.68192389
125MP0002085_abnormal_embryonic_tissue0.67222867
126MP0005248_abnormal_Harderian_gland0.67107718
127MP0000647_abnormal_sebaceous_gland0.66836357
128MP0005376_homeostasis/metabolism_phenot0.66170724
129MP0002233_abnormal_nose_morphology0.66136923
130MP0002160_abnormal_reproductive_system0.64342177
131MP0003566_abnormal_cell_adhesion0.63818947
132MP0005395_other_phenotype0.63602544
133MP0001853_heart_inflammation0.63037743
134MP0000653_abnormal_sex_gland0.63014463
135MP0002084_abnormal_developmental_patter0.61426325
136MP0001293_anophthalmia0.61256553
137MP0001243_abnormal_dermal_layer0.60844393
138MP0002254_reproductive_system_inflammat0.60828793
139* MP0000313_abnormal_cell_death0.60444889
140MP0009763_increased_sensitivity_to0.60150543
141MP0003941_abnormal_skin_development0.59475720
142MP0001915_intracranial_hemorrhage0.58245640
143MP0005389_reproductive_system_phenotype0.57178913
144MP0002060_abnormal_skin_morphology0.57129579
145MP0005397_hematopoietic_system_phenotyp0.56588637

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.16695908
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.12828576
3Hypobetalipoproteinemia (HP:0003563)4.34303655
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.16763049
5Chromsome breakage (HP:0040012)3.85735106
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85594623
7Deep venous thrombosis (HP:0002625)3.82067656
8Xanthomatosis (HP:0000991)3.73752488
9Abnormality of pyrimidine metabolism (HP:0004353)3.63638958
10Hyperammonemia (HP:0001987)3.52995544
11Abnormality of sulfur amino acid metabolism (HP:0004339)3.52189704
12Hyperglycinuria (HP:0003108)3.45410855
13Hypolipoproteinemia (HP:0010981)3.42696279
14Abnormality of methionine metabolism (HP:0010901)3.29819683
15Prolonged partial thromboplastin time (HP:0003645)3.23942310
16Hypochromic microcytic anemia (HP:0004840)3.23574251
17Hyperglycinemia (HP:0002154)3.22844711
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.20838304
19Abnormality of serine family amino acid metabolism (HP:0010894)3.10650822
20Abnormality of glycine metabolism (HP:0010895)3.10650822
21Hypoglycemic coma (HP:0001325)3.07559965
22Hypoalphalipoproteinemia (HP:0003233)3.00032860
23Abnormality of nucleobase metabolism (HP:0010932)2.94531797
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.87954854
25Ketosis (HP:0001946)2.85451609
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.83940491
27Hyperbilirubinemia (HP:0002904)2.81840602
28Fat malabsorption (HP:0002630)2.79410786
29Abnormality of the intrinsic pathway (HP:0010989)2.78196603
30Gout (HP:0001997)2.77589662
31Multiple enchondromatosis (HP:0005701)2.76549707
32Poikilocytosis (HP:0004447)2.71798050
33Hyperlipoproteinemia (HP:0010980)2.69600572
34Ankyloglossia (HP:0010296)2.68960811
35Abnormal cartilage morphology (HP:0002763)2.67345467
36Microglossia (HP:0000171)2.65840349
37Abnormality of purine metabolism (HP:0004352)2.59978216
38Epidermoid cyst (HP:0200040)2.59198403
39Abnormality of fatty-acid metabolism (HP:0004359)2.55922478
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.54134640
41Abnormality of serum amino acid levels (HP:0003112)2.53362186
42Hepatocellular carcinoma (HP:0001402)2.52182401
43Increased serum pyruvate (HP:0003542)2.47978804
44Dicarboxylic aciduria (HP:0003215)2.47644832
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47644832
46Increased nuchal translucency (HP:0010880)2.47011484
47Oral leukoplakia (HP:0002745)2.46492725
48Abnormality of glycolysis (HP:0004366)2.44583037
49Abnormality of the common coagulation pathway (HP:0010990)2.44097184
50Increased purine levels (HP:0004368)2.42237246
51Hyperuricemia (HP:0002149)2.42237246
52Overlapping toe (HP:0001845)2.37736345
53Right ventricular cardiomyopathy (HP:0011663)2.35824470
54Termporal pattern (HP:0011008)2.32342340
55Insidious onset (HP:0003587)2.32342340
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31500113
57Steatorrhea (HP:0002570)2.30439397
58Abnormality of chromosome stability (HP:0003220)2.29761158
59Papillary thyroid carcinoma (HP:0002895)2.28303307
60Acanthocytosis (HP:0001927)2.27989494
61Asymmetry of the thorax (HP:0001555)2.27935391
62Nephroblastoma (Wilms tumor) (HP:0002667)2.26641195
63Complement deficiency (HP:0004431)2.25949049
64Proximal tubulopathy (HP:0000114)2.24113176
65Spastic diplegia (HP:0001264)2.23313993
66Abnormality of the preputium (HP:0100587)2.22653196
67Metaphyseal cupping (HP:0003021)2.21555429
68Flat acetabular roof (HP:0003180)2.19718114
69Lethargy (HP:0001254)2.18738234
70Deviation of the thumb (HP:0009603)2.18690509
71Progressive muscle weakness (HP:0003323)2.17822461
72Malnutrition (HP:0004395)2.17018869
73Hypercholesterolemia (HP:0003124)2.16423390
74Premature rupture of membranes (HP:0001788)2.13874404
75Septate vagina (HP:0001153)2.12379274
76Delayed CNS myelination (HP:0002188)2.12226343
77Deep philtrum (HP:0002002)2.11843798
78Progressive external ophthalmoplegia (HP:0000590)2.10362733
79Nausea (HP:0002018)2.10306820
80Impulsivity (HP:0100710)2.09945873
81Abnormality of oral frenula (HP:0000190)2.09816658
82Embryonal renal neoplasm (HP:0011794)2.09683089
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.05684935
84Osteolytic defects of the hand bones (HP:0009699)2.05684935
85Carpal bone hypoplasia (HP:0001498)2.03097267
86Sparse lateral eyebrow (HP:0005338)2.02498207
87Cholelithiasis (HP:0001081)2.02180712
88Birth length less than 3rd percentile (HP:0003561)2.01615447
89Missing ribs (HP:0000921)2.01554502
90Metabolic acidosis (HP:0001942)2.01323192
91Ketoacidosis (HP:0001993)2.01154061
92Abnormality of the umbilical cord (HP:0010881)2.00472772
93Abnormality of transition element cation homeostasis (HP:0011030)2.00105917
94Selective tooth agenesis (HP:0001592)1.99783171
95Rhabdomyolysis (HP:0003201)1.99168474
96Generalized aminoaciduria (HP:0002909)1.97251118
97Breast hypoplasia (HP:0003187)1.97150341
98Abnormality of iron homeostasis (HP:0011031)1.95232064
99Meckel diverticulum (HP:0002245)1.95210610
100Uterine leiomyosarcoma (HP:0002891)1.95110245
101Leiomyosarcoma (HP:0100243)1.95110245
102Reticulocytosis (HP:0001923)1.94172570
103Joint hemorrhage (HP:0005261)1.94100681
104Proximal placement of thumb (HP:0009623)1.93931259
105Abnormal gallbladder morphology (HP:0012437)1.93451393
106Tongue fasciculations (HP:0001308)1.92460129
107Short nail (HP:0001799)1.92071661
108Vascular calcification (HP:0004934)1.91225520
109Microvesicular hepatic steatosis (HP:0001414)1.90135319
110Capillary hemangiomas (HP:0005306)1.89492370
111Abnormal foot bone ossification (HP:0010675)1.89192877
112Abnormalities of placenta or umbilical cord (HP:0001194)1.88923780
113Abnormal umbilical cord blood vessels (HP:0011403)1.88329754
114Single umbilical artery (HP:0001195)1.88329754
115Abnormality of the fetal cardiovascular system (HP:0010948)1.88329754
116Cholecystitis (HP:0001082)1.86454461
117Abnormal gallbladder physiology (HP:0012438)1.86454461
118Abnormal spermatogenesis (HP:0008669)1.85425465
119Abnormality of complement system (HP:0005339)1.84288047
120Abnormal enzyme/coenzyme activity (HP:0012379)1.81453307
121Reduced antithrombin III activity (HP:0001976)1.81278478
122Duodenal stenosis (HP:0100867)1.80227918
123Small intestinal stenosis (HP:0012848)1.80227918
124Hyperinsulinemic hypoglycemia (HP:0000825)1.79768688
125Chorioretinal atrophy (HP:0000533)1.79656182
126Muscle fibrillation (HP:0010546)1.77468290
127Abnormality of the ileum (HP:0001549)1.77018190
128Abnormal lung lobation (HP:0002101)1.74471116
129Megaloblastic anemia (HP:0001889)1.74328265
130Abnormality of reticulocytes (HP:0004312)1.73211919
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.72935240
132Myelodysplasia (HP:0002863)1.72321838
133Rhabdomyosarcoma (HP:0002859)1.71136913
134Cardiovascular calcification (HP:0011915)1.70327889
135Curly hair (HP:0002212)1.70312545
136Cutaneous melanoma (HP:0012056)1.70015626
137Increased serum ferritin (HP:0003281)1.69337716
138Malignant gastrointestinal tract tumors (HP:0006749)1.69309137
139Gastrointestinal carcinoma (HP:0002672)1.69309137
140Late onset (HP:0003584)1.68751802
141Uterine neoplasm (HP:0010784)1.68291791
142Heterotopia (HP:0002282)1.68117673
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67126097
144Degeneration of anterior horn cells (HP:0002398)1.66822138
145Abnormality of the anterior horn cell (HP:0006802)1.66822138
146Abnormality of alkaline phosphatase activity (HP:0004379)1.66545989
147Abnormality of the gallbladder (HP:0005264)1.66433768
148Ependymoma (HP:0002888)1.66114530
149Sparse eyelashes (HP:0000653)1.65932954
150Abnormal tarsal ossification (HP:0008369)1.65590592
151Unilateral renal agenesis (HP:0000122)1.65565516
152Cafe-au-lait spot (HP:0000957)1.65125141
153Abnormal biliary tract physiology (HP:0012439)1.63912701
154Bile duct proliferation (HP:0001408)1.63912701
155Absent radius (HP:0003974)1.62921956
156Secondary amenorrhea (HP:0000869)1.62348252
157Neoplasm of the liver (HP:0002896)1.62312764
158Breast carcinoma (HP:0003002)1.61678947
159Spinal cord lesions (HP:0100561)1.60285804
160Syringomyelia (HP:0003396)1.60285804
161Renal cortical cysts (HP:0000803)1.59385731
162Volvulus (HP:0002580)1.58922850
163Pendular nystagmus (HP:0012043)1.56940581
164Glossoptosis (HP:0000162)1.56136659
165Entropion (HP:0000621)1.55753077
166Ankle contracture (HP:0006466)1.54889280
167Renal cell carcinoma (HP:0005584)1.54666423
168Conjugated hyperbilirubinemia (HP:0002908)1.53332415
169Transitional cell carcinoma of the bladder (HP:0006740)1.52636895
170Astrocytoma (HP:0009592)1.51469113
171Abnormality of the astrocytes (HP:0100707)1.51469113
172Choanal atresia (HP:0000453)1.49668388
173Abnormality of the phalanges of the hallux (HP:0010057)1.49519512
174Facial cleft (HP:0002006)1.48260705
175Thyroid carcinoma (HP:0002890)1.46742578
17611 pairs of ribs (HP:0000878)1.46716143
177Absent forearm bone (HP:0003953)1.46411588
178Aplasia involving forearm bones (HP:0009822)1.46411588
179Orthostatic hypotension (HP:0001278)1.45765750
180Pterygium (HP:0001059)1.44766627
181Trismus (HP:0000211)1.44641736
182Advanced eruption of teeth (HP:0006288)1.44636788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.22936334
2EIF2AK13.03253984
3BUB12.82600422
4WEE12.72919584
5PDK32.61303193
6PDK42.61303193
7EPHA22.33827897
8TTK2.22157501
9CDC72.02463139
10NEK21.98916375
11ERN11.96411432
12NEK11.94750477
13PDK21.92457056
14CDK121.84697575
15ACVR1B1.77368943
16BRSK21.65381465
17TESK11.65325421
18STK101.64937101
19NME21.55075405
20FLT31.51887940
21DYRK31.49561775
22STK31.45932629
23SMG11.45781978
24STK38L1.44921597
25LATS21.43268745
26PASK1.42936327
27RPS6KA41.42913347
28LATS11.42306095
29EIF2AK31.42097373
30PLK11.39826027
31PLK41.37289209
32TESK21.34172852
33RPS6KB21.32239293
34CDK71.28535960
35ZAK1.26614988
36SRPK11.26476248
37TAOK21.25717286
38MAP3K31.23508567
39AURKB1.23231134
40PDGFRA1.20694261
41BRAF1.19743664
42PNCK1.18014223
43MAP3K81.16873794
44PKN21.15888384
45STK41.11441046
46TGFBR11.08245340
47NEK91.05178929
48CDK41.05111904
49MAP2K31.04049827
50TBK11.02663588
51FGFR41.02275604
52KDR1.01881685
53PIM21.00109718
54MAP3K90.99921306
55BRD40.99473774
56CHEK20.98812840
57VRK20.98776330
58TAF10.98404182
59PIM10.97824137
60TLK10.96837608
61ATR0.96299506
62PBK0.92437371
63MKNK10.92295825
64ERBB30.91599868
65AURKA0.90063581
66MAPK110.89763380
67MST1R0.88689595
68PTK20.86902849
69CDK60.86443690
70GRK60.83528017
71CHEK10.82998530
72LMTK20.82421285
73PAK40.82212901
74MAP3K100.81838629
75DYRK1B0.78976825
76TRIB30.78341491
77SIK10.77861281
78NEK60.77690869
79TTN0.76402591
80GRK10.76347542
81MAPKAPK30.75846598
82STK160.75449157
83CDK80.75408823
84STK240.70231621
85LRRK20.67160041
86MTOR0.66858114
87ERBB40.66159935
88CDK90.64238572
89MAP3K120.63330224
90TYK20.62905069
91MAP3K110.62875736
92PLK30.61321790
93EEF2K0.61027393
94MET0.60147809
95ABL20.59543531
96TRIM280.59407975
97BRSK10.58921069
98PINK10.58897485
99ICK0.58847966
100CDK10.58635732
101VRK10.57385835
102TAOK30.57000851
103ATM0.56511599
104FGFR10.56278931
105PAK20.55939404
106ARAF0.55319804
107KSR10.55180896
108TSSK60.55033102
109MELK0.54212597
110KSR20.53390085
111STK390.52813880
112AKT20.51079059
113IRAK30.50978489
114ILK0.50857497
115MST40.50259010
116EIF2AK20.49515887
117RAF10.49177524
118MKNK20.48762586
119CLK10.48018785
120CSNK2A10.47648518
121YES10.46670762
122CDK20.45713857
123CCNB10.45498743
124DMPK0.45025310
125AKT30.44970512
126TGFBR20.42834619
127CSNK1E0.42555743
128PRKCI0.41232567
129EPHA30.40348156
130MAPK70.40116274
131SCYL20.40054145
132CSNK2A20.39853156
133BCR0.38421482
134RPS6KA50.38401933
135MAP2K60.35054449
136PRKAA10.34321622
137IKBKB0.33633992

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.68871479
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41816230
3One carbon pool by folate_Homo sapiens_hsa006702.31914588
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28360212
5Selenocompound metabolism_Homo sapiens_hsa004502.24417347
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24257104
7DNA replication_Homo sapiens_hsa030302.14702755
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11463959
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00576317
10Tryptophan metabolism_Homo sapiens_hsa003801.93624749
11Fatty acid degradation_Homo sapiens_hsa000711.93473504
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84989044
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.78589617
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76736926
15Arginine biosynthesis_Homo sapiens_hsa002201.74952506
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72628072
17Vitamin B6 metabolism_Homo sapiens_hsa007501.72159718
18Thyroid cancer_Homo sapiens_hsa052161.71365677
19Propanoate metabolism_Homo sapiens_hsa006401.71193441
20Biosynthesis of amino acids_Homo sapiens_hsa012301.66343289
21Mismatch repair_Homo sapiens_hsa034301.65275341
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58509836
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.58469472
24Proteasome_Homo sapiens_hsa030501.56388639
25Carbon metabolism_Homo sapiens_hsa012001.55869565
26Folate biosynthesis_Homo sapiens_hsa007901.55277310
27Pyruvate metabolism_Homo sapiens_hsa006201.53344169
28Nitrogen metabolism_Homo sapiens_hsa009101.52647932
29Peroxisome_Homo sapiens_hsa041461.50273590
30Complement and coagulation cascades_Homo sapiens_hsa046101.49552719
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46592670
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45042481
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43756288
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41555704
35Chemical carcinogenesis_Homo sapiens_hsa052041.39582405
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38371648
37Pentose phosphate pathway_Homo sapiens_hsa000301.38130146
38Caffeine metabolism_Homo sapiens_hsa002321.37581353
39RNA transport_Homo sapiens_hsa030131.36991717
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32897348
41Retinol metabolism_Homo sapiens_hsa008301.31662376
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29929986
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.29398901
44Fatty acid metabolism_Homo sapiens_hsa012121.25608582
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25319540
46Base excision repair_Homo sapiens_hsa034101.21836721
47Adherens junction_Homo sapiens_hsa045201.21682334
48Sulfur relay system_Homo sapiens_hsa041221.21259026
49Pyrimidine metabolism_Homo sapiens_hsa002401.20804069
50PPAR signaling pathway_Homo sapiens_hsa033201.20683455
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18333203
52beta-Alanine metabolism_Homo sapiens_hsa004101.16721967
53Glutathione metabolism_Homo sapiens_hsa004801.16528693
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.14484755
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10814715
56Homologous recombination_Homo sapiens_hsa034401.10404871
57Nucleotide excision repair_Homo sapiens_hsa034201.10151779
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.09804037
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.05221945
60Butanoate metabolism_Homo sapiens_hsa006501.05042249
61Fructose and mannose metabolism_Homo sapiens_hsa000511.03725349
62Cell cycle_Homo sapiens_hsa041101.03165949
63Phenylalanine metabolism_Homo sapiens_hsa003601.03091541
64Histidine metabolism_Homo sapiens_hsa003401.02123481
65Ribosome_Homo sapiens_hsa030101.01125108
66RNA polymerase_Homo sapiens_hsa030201.00326810
67Small cell lung cancer_Homo sapiens_hsa052221.00301166
68Fat digestion and absorption_Homo sapiens_hsa049750.97920421
69Spliceosome_Homo sapiens_hsa030400.97237318
70Starch and sucrose metabolism_Homo sapiens_hsa005000.95479796
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95284580
72Sulfur metabolism_Homo sapiens_hsa009200.95102405
73Arginine and proline metabolism_Homo sapiens_hsa003300.93178743
74Oocyte meiosis_Homo sapiens_hsa041140.91525240
75Chronic myeloid leukemia_Homo sapiens_hsa052200.87029169
76N-Glycan biosynthesis_Homo sapiens_hsa005100.86731502
77Tyrosine metabolism_Homo sapiens_hsa003500.86481637
78Fanconi anemia pathway_Homo sapiens_hsa034600.85981654
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84582540
80Systemic lupus erythematosus_Homo sapiens_hsa053220.83418108
81MicroRNAs in cancer_Homo sapiens_hsa052060.82357651
82Vitamin digestion and absorption_Homo sapiens_hsa049770.82199393
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80476045
84Pancreatic cancer_Homo sapiens_hsa052120.79371788
85Protein export_Homo sapiens_hsa030600.79099677
86Bladder cancer_Homo sapiens_hsa052190.77601197
87Galactose metabolism_Homo sapiens_hsa000520.77577127
88Steroid biosynthesis_Homo sapiens_hsa001000.76064537
89Lysine degradation_Homo sapiens_hsa003100.73682999
90p53 signaling pathway_Homo sapiens_hsa041150.72770457
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71805154
92ABC transporters_Homo sapiens_hsa020100.71767922
93Hippo signaling pathway_Homo sapiens_hsa043900.71011133
94Prostate cancer_Homo sapiens_hsa052150.70917914
95TGF-beta signaling pathway_Homo sapiens_hsa043500.69126517
96Endometrial cancer_Homo sapiens_hsa052130.65107414
97Proteoglycans in cancer_Homo sapiens_hsa052050.64200854
98Metabolic pathways_Homo sapiens_hsa011000.61381158
99Basal transcription factors_Homo sapiens_hsa030220.61237259
100Renal cell carcinoma_Homo sapiens_hsa052110.60838083
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60774594
102Bile secretion_Homo sapiens_hsa049760.59993992
103RNA degradation_Homo sapiens_hsa030180.59923739
104Staphylococcus aureus infection_Homo sapiens_hsa051500.59548491
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59189535
106Non-small cell lung cancer_Homo sapiens_hsa052230.58821137
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53256576
108Purine metabolism_Homo sapiens_hsa002300.51560308
109Fatty acid elongation_Homo sapiens_hsa000620.50953892
110Tight junction_Homo sapiens_hsa045300.50730700
111Non-homologous end-joining_Homo sapiens_hsa034500.50472981
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50458590
113Linoleic acid metabolism_Homo sapiens_hsa005910.49473367
114Colorectal cancer_Homo sapiens_hsa052100.49311655
115Glycerolipid metabolism_Homo sapiens_hsa005610.47883266
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47590582
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45734226
118Sphingolipid metabolism_Homo sapiens_hsa006000.45731292
119Insulin signaling pathway_Homo sapiens_hsa049100.44906985
120Focal adhesion_Homo sapiens_hsa045100.40847325
121AMPK signaling pathway_Homo sapiens_hsa041520.40076362
122Melanoma_Homo sapiens_hsa052180.37558472
123mTOR signaling pathway_Homo sapiens_hsa041500.37145097
124ECM-receptor interaction_Homo sapiens_hsa045120.36422773
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35602204
126Viral carcinogenesis_Homo sapiens_hsa052030.35281716
127mRNA surveillance pathway_Homo sapiens_hsa030150.34482146
128Fatty acid biosynthesis_Homo sapiens_hsa000610.32872673
129Antigen processing and presentation_Homo sapiens_hsa046120.31233656
130Legionellosis_Homo sapiens_hsa051340.27982839
131Arachidonic acid metabolism_Homo sapiens_hsa005900.27190631
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26080960
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24983659

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