MTFP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)5.19201592
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.01320806
3NADH metabolic process (GO:0006734)4.88034742
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.72570133
5DNA strand elongation involved in DNA replication (GO:0006271)4.69254789
6establishment of integrated proviral latency (GO:0075713)4.67187681
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62950675
8ATP synthesis coupled proton transport (GO:0015986)4.62950675
9DNA strand elongation (GO:0022616)4.51158748
10ribosomal small subunit assembly (GO:0000028)4.46035322
11respiratory electron transport chain (GO:0022904)4.43940501
12telomere maintenance via semi-conservative replication (GO:0032201)4.38013480
13ribosomal small subunit biogenesis (GO:0042274)4.35313418
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.34530414
15electron transport chain (GO:0022900)4.31901374
16succinate metabolic process (GO:0006105)4.30081359
17maturation of SSU-rRNA (GO:0030490)4.24077439
18establishment of viral latency (GO:0019043)4.20628926
19regulation of acyl-CoA biosynthetic process (GO:0050812)4.18728678
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.18416901
21oxaloacetate metabolic process (GO:0006107)4.13764581
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.09827564
23proteasome assembly (GO:0043248)4.09714490
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.09531525
25vocalization behavior (GO:0071625)4.08243373
26viral transcription (GO:0019083)4.07082658
27synaptic vesicle exocytosis (GO:0016079)4.05800570
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.04896061
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.04061856
30negative regulation of ligase activity (GO:0051352)4.04061856
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.02735115
32regulation of mitochondrial translation (GO:0070129)4.02004801
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.98598591
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98095754
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.97750602
36regulation of cofactor metabolic process (GO:0051193)3.95134278
37regulation of coenzyme metabolic process (GO:0051196)3.95134278
38formation of translation preinitiation complex (GO:0001731)3.92024647
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.91515433
40translational termination (GO:0006415)3.91369178
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88100936
42chaperone-mediated protein transport (GO:0072321)3.84738110
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.84200496
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82307137
45DNA replication checkpoint (GO:0000076)3.82074064
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81666487
47chromatin remodeling at centromere (GO:0031055)3.79934252
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.79723749
49CENP-A containing nucleosome assembly (GO:0034080)3.76995481
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76832045
51purine nucleobase biosynthetic process (GO:0009113)3.68155857
52cotranslational protein targeting to membrane (GO:0006613)3.67884726
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67221751
54protein targeting to ER (GO:0045047)3.65043597
55translational elongation (GO:0006414)3.65014160
56regulation of glutamate receptor signaling pathway (GO:1900449)3.64724048
57DNA unwinding involved in DNA replication (GO:0006268)3.63104895
58protein localization to synapse (GO:0035418)3.62601344
59ribosomal large subunit biogenesis (GO:0042273)3.62548745
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60470242
61glutamate secretion (GO:0014047)3.59524572
62telomere maintenance via recombination (GO:0000722)3.58067925
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57792845
64spliceosomal snRNP assembly (GO:0000387)3.57646805
65regulation of cellular amino acid metabolic process (GO:0006521)3.57638343
66oxidative phosphorylation (GO:0006119)3.56822756
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56615758
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56615758
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56615758
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.56296867
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.56296867
72rRNA modification (GO:0000154)3.55580036
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50422228
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.50422228
75regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.50218606
76nucleobase biosynthetic process (GO:0046112)3.50093272
77IMP biosynthetic process (GO:0006188)3.49641486
78ribonucleoprotein complex biogenesis (GO:0022613)3.48894362
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46400099
80protein targeting to mitochondrion (GO:0006626)3.46345748
81protein localization to endoplasmic reticulum (GO:0070972)3.45860188
82cell communication by electrical coupling (GO:0010644)3.45811881
83neurotransmitter-gated ion channel clustering (GO:0072578)3.45509550
84detection of calcium ion (GO:0005513)3.45227360
85mitotic recombination (GO:0006312)3.44910964
86signal transduction involved in cell cycle checkpoint (GO:0072395)3.43720371
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42793246
88translation (GO:0006412)3.42665931
89synaptic vesicle docking involved in exocytosis (GO:0016081)3.42107511
90cardiac muscle contraction (GO:0060048)3.41874586
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.41662040
92translational initiation (GO:0006413)3.40199034
93cardiac myofibril assembly (GO:0055003)3.39165466
94neuronal action potential propagation (GO:0019227)3.39001233
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35590374
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34448184
97inner mitochondrial membrane organization (GO:0007007)3.32898437
98establishment of protein localization to mitochondrion (GO:0072655)3.28869000
99rRNA processing (GO:0006364)3.28328498
100DNA replication initiation (GO:0006270)3.27596991
101pseudouridine synthesis (GO:0001522)3.26197488
102regulation of cell communication by electrical coupling (GO:0010649)3.25804209
103aspartate family amino acid catabolic process (GO:0009068)3.25696873
104L-serine metabolic process (GO:0006563)3.25606612
105ATP biosynthetic process (GO:0006754)3.25548917
106ATP hydrolysis coupled proton transport (GO:0015991)3.24176532
107energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.24176532
108positive regulation of ligase activity (GO:0051351)3.23057826
109regulation of oxidative phosphorylation (GO:0002082)3.22496184
110ribosome biogenesis (GO:0042254)3.22492222
111protein localization to kinetochore (GO:0034501)3.22108371
112neurotransmitter secretion (GO:0007269)3.19138695
113regulation of ubiquitin-protein transferase activity (GO:0051438)3.19040919
114cellular component biogenesis (GO:0044085)3.18537654
115viral life cycle (GO:0019058)3.18472641
116pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.17755186
117ribosome assembly (GO:0042255)3.17561771
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17185744
119protein localization to mitochondrion (GO:0070585)3.16508414
120ionotropic glutamate receptor signaling pathway (GO:0035235)3.16130222
121nucleobase-containing small molecule interconversion (GO:0015949)3.14897380
122termination of RNA polymerase III transcription (GO:0006386)3.13154170
123transcription elongation from RNA polymerase III promoter (GO:0006385)3.13154170
124DNA ligation (GO:0006266)3.12035700
125cell communication involved in cardiac conduction (GO:0086065)3.11578377
126cullin deneddylation (GO:0010388)3.11289401
127sarcomere organization (GO:0045214)3.10940438
128glutamate receptor signaling pathway (GO:0007215)3.10876328
129rRNA metabolic process (GO:0016072)3.10195424
130negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09965674
131pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.09564536
132regulation of ligase activity (GO:0051340)3.09155736
133nucleotide-excision repair, DNA gap filling (GO:0006297)3.08899716
134protein maturation by protein folding (GO:0022417)3.08831460
135regulation of sulfur metabolic process (GO:0042762)3.08615876
136iron-sulfur cluster assembly (GO:0016226)3.07562325
137metallo-sulfur cluster assembly (GO:0031163)3.07562325
138gamma-aminobutyric acid signaling pathway (GO:0007214)3.06969628
139neuron cell-cell adhesion (GO:0007158)3.06739360
140mitotic metaphase plate congression (GO:0007080)3.06208832
141transcription-coupled nucleotide-excision repair (GO:0006283)3.06035492
142dicarboxylic acid catabolic process (GO:0043649)3.05466864
143DNA replication-independent nucleosome assembly (GO:0006336)3.04221897
144DNA replication-independent nucleosome organization (GO:0034724)3.04221897
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04107204
146cellular protein complex disassembly (GO:0043624)3.04035996
147regulation of synaptic vesicle exocytosis (GO:2000300)3.03939617
148mitotic sister chromatid segregation (GO:0000070)3.03733397
149IMP metabolic process (GO:0046040)3.02967058
150DNA replication-dependent nucleosome organization (GO:0034723)3.02833675
151DNA replication-dependent nucleosome assembly (GO:0006335)3.02833675
152guanosine-containing compound biosynthetic process (GO:1901070)3.01496104
153neuron-neuron synaptic transmission (GO:0007270)3.01308904
154locomotory exploration behavior (GO:0035641)2.99539359
155negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.98920070
156regulation of synaptic vesicle transport (GO:1902803)2.98294093
157myofibril assembly (GO:0030239)2.97702363
158synaptic transmission, glutamatergic (GO:0035249)2.96119045
159sarcoplasmic reticulum calcium ion transport (GO:0070296)2.96090944
160lysine metabolic process (GO:0006553)2.95365650
161lysine catabolic process (GO:0006554)2.95365650
1622-oxoglutarate metabolic process (GO:0006103)2.92707703
163regulation of membrane repolarization (GO:0060306)2.89606933
164cellular ketone body metabolic process (GO:0046950)2.88746396
165regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87869241
166regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85931541
167positive regulation of synapse maturation (GO:0090129)2.84642444
168gluconeogenesis (GO:0006094)2.83912102
169protein complex biogenesis (GO:0070271)2.83126075
170positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82745863
171regulation of actin filament-based movement (GO:1903115)2.82228421
172gamma-aminobutyric acid transport (GO:0015812)2.79743825
173mitochondrial genome maintenance (GO:0000002)2.78034492
174negative regulation of potassium ion transmembrane transport (GO:1901380)2.77936658
175hydrogen ion transmembrane transport (GO:1902600)2.76270363
176G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75730342
177regulation of relaxation of muscle (GO:1901077)2.74564398
178regulation of calcium ion transmembrane transport (GO:1903169)2.73721186
179regulation of calcium ion transmembrane transporter activity (GO:1901019)2.73721186
180striated muscle contraction (GO:0006941)2.71868877
181regulation of postsynaptic membrane potential (GO:0060078)2.69277658
182response to histamine (GO:0034776)2.69055931
183cardiac muscle hypertrophy (GO:0003300)2.68546478
184purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.68412446
185purine nucleoside triphosphate biosynthetic process (GO:0009145)2.68202682
186aerobic respiration (GO:0009060)2.67797996
187positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.67166015
188mitochondrial respiratory chain complex assembly (GO:0033108)2.66940993
189cardiac muscle cell action potential (GO:0086001)2.66858663
190ventricular cardiac muscle cell action potential (GO:0086005)2.66404101
191synaptic vesicle maturation (GO:0016188)2.65814050
192hexose biosynthetic process (GO:0019319)2.65205405
193regulation of cellular respiration (GO:0043457)2.64972243
194dicarboxylic acid biosynthetic process (GO:0043650)2.64766145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48794052
2EZH2_22144423_ChIP-Seq_EOC_Human5.90591392
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.20681381
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03397505
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98790008
6GBX2_23144817_ChIP-Seq_PC3_Human3.94025556
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.75266518
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41352065
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.38203943
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.29814563
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18843442
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.16581393
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14155876
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12916590
15MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12465687
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.98195887
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88062145
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80320266
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71960426
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70108208
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69935447
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59678961
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.58543742
24REST_21632747_ChIP-Seq_MESCs_Mouse2.57732229
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56641901
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45402989
27XRN2_22483619_ChIP-Seq_HELA_Human2.44669234
28TAF15_26573619_Chip-Seq_HEK293_Human2.43365086
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41459211
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39094579
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.36168086
32JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36043747
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30365789
34RARB_27405468_Chip-Seq_BRAIN_Mouse2.28950228
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25439481
36DCP1A_22483619_ChIP-Seq_HELA_Human2.24031800
37VDR_23849224_ChIP-Seq_CD4+_Human2.12251733
38FOXP3_21729870_ChIP-Seq_TREG_Human2.07777061
39MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06894962
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06615761
41GABP_19822575_ChIP-Seq_HepG2_Human2.06184923
42JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05801542
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04980106
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02492051
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99802012
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96543242
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95032757
48TTF2_22483619_ChIP-Seq_HELA_Human1.93633662
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93575457
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93251553
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93251553
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91618895
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.91127853
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88639584
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88126626
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87398877
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.87205425
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83763811
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81529740
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80936106
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.78735996
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77925439
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.77358916
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73035736
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.71012818
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70652940
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69262818
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69046223
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68952808
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68486920
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68091486
72ZNF274_21170338_ChIP-Seq_K562_Hela1.67851424
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.66690532
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66348968
75ELK1_19687146_ChIP-ChIP_HELA_Human1.62232028
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62186904
77DROSHA_22980978_ChIP-Seq_HELA_Human1.61780806
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61180407
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58349448
80VDR_22108803_ChIP-Seq_LS180_Human1.58181249
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58129645
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56684011
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56576365
84SMAD4_21799915_ChIP-Seq_A2780_Human1.56208191
85* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55995226
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55489470
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52069376
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47077055
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43407302
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42831593
91AR_21572438_ChIP-Seq_LNCaP_Human1.39699771
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39592774
93KDM5A_27292631_Chip-Seq_BREAST_Human1.38587219
94IGF1R_20145208_ChIP-Seq_DFB_Human1.38000897
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37546641
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36751225
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.35008210
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32864271
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.29097737
100P300_19829295_ChIP-Seq_ESCs_Human1.28530690
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28279512
102AR_21909140_ChIP-Seq_LNCAP_Human1.27824341
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27759545
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27487088
105MYC_22102868_ChIP-Seq_BL_Human1.27143895
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26800746
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26214594
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26211822
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24997009
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23283664
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.22891373
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22654250
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.21616912
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.20994293
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19842675
116AR_25329375_ChIP-Seq_VCAP_Human1.19522287
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16308441
118FUS_26573619_Chip-Seq_HEK293_Human1.16286233
119CIITA_25753668_ChIP-Seq_RAJI_Human1.16074199
120HTT_18923047_ChIP-ChIP_STHdh_Human1.15480543
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15200326
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14792948
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14576370
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12961783
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.12666700
126ZNF263_19887448_ChIP-Seq_K562_Human1.11506473
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11031282
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10835768
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09759506
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09531957
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09119538
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08864621
133MYC_18940864_ChIP-ChIP_HL60_Human1.08721216
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08166047
135KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07117453
136DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05630498
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05437289
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04743327
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04227642
140ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04181693
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01690404
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.01154633
143SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00528654
144TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00466052
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98753695
146CBP_20019798_ChIP-Seq_JUKART_Human0.98753695
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97770340
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97409264
149CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97178944
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95185108
151AR_19668381_ChIP-Seq_PC3_Human0.95056703
152TFEB_21752829_ChIP-Seq_HELA_Human0.94892266
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94197603
154PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93966542
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93065571
156THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92965154
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92430422
158ER_23166858_ChIP-Seq_MCF-7_Human0.92230262
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92168223
160STAT3_23295773_ChIP-Seq_U87_Human0.91316367
161TCF4_23295773_ChIP-Seq_U87_Human0.91252951
162GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91247134
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90650987
164* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89619557
165CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89128521
166CTCF_27219007_Chip-Seq_Bcells_Human0.88677129
167VDR_21846776_ChIP-Seq_THP-1_Human0.88420810
168NOTCH1_21737748_ChIP-Seq_TLL_Human0.88192743
169OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87849544
170PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86785568
171KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86510528
172FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85893871
173LXR_22158963_ChIP-Seq_LIVER_Mouse0.85167030
174HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84890633
175ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84284190
176ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84220607
177TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84208568
178MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83132750
179CBX2_27304074_Chip-Seq_ESCs_Mouse0.83006233
180CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82213534
181BCAT_22108803_ChIP-Seq_LS180_Human0.81235208
182OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80907947
183TET1_21451524_ChIP-Seq_MESCs_Mouse0.80684724
184RING1B_27294783_Chip-Seq_ESCs_Mouse0.79636091
185CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79628629
186MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78580741
187PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76946072
188JUN_21703547_ChIP-Seq_K562_Human0.76502259
189E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76416860
190POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75818746
191TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75818746
192SMAD4_21741376_ChIP-Seq_HESCs_Human0.75475606
193SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74306958
194ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.73898381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02593404
2MP0002837_dystrophic_cardiac_calcinosis4.93862036
3MP0010094_abnormal_chromosome_stability4.67544584
4MP0004957_abnormal_blastocyst_morpholog4.41885972
5MP0004859_abnormal_synaptic_plasticity4.19802770
6MP0003111_abnormal_nucleus_morphology4.16627281
7MP0008058_abnormal_DNA_repair4.16247324
8MP0003646_muscle_fatigue3.79262519
9MP0003077_abnormal_cell_cycle3.72547853
10MP0003880_abnormal_central_pattern3.70665281
11MP0008932_abnormal_embryonic_tissue3.36387869
12MP0004215_abnormal_myocardial_fiber3.26150380
13MP0000751_myopathy3.21215876
14MP0008057_abnormal_DNA_replication2.88359279
15MP0003635_abnormal_synaptic_transmissio2.87440366
16MP0008007_abnormal_cellular_replicative2.78175740
17MP0009745_abnormal_behavioral_response2.64428987
18MP0003786_premature_aging2.53686795
19MP0009046_muscle_twitch2.51182673
20MP0004084_abnormal_cardiac_muscle2.50547769
21MP0002064_seizures2.47624160
22MP0004036_abnormal_muscle_relaxation2.38597817
23MP0003186_abnormal_redox_activity2.38558704
24MP0009333_abnormal_splenocyte_physiolog2.28510220
25MP0000749_muscle_degeneration2.24828206
26MP0002063_abnormal_learning/memory/cond2.22793180
27MP0005330_cardiomyopathy2.18452845
28MP0001968_abnormal_touch/_nociception2.17326414
29MP0002822_catalepsy2.15304704
30MP0002736_abnormal_nociception_after2.14264978
31MP0006036_abnormal_mitochondrial_physio2.14107225
32MP0002272_abnormal_nervous_system2.08504453
33MP0001730_embryonic_growth_arrest2.01514268
34MP0002572_abnormal_emotion/affect_behav2.00726339
35MP0004270_analgesia1.94041640
36MP0003137_abnormal_impulse_conducting1.93322938
37MP0002163_abnormal_gland_morphology1.93037985
38MP0000350_abnormal_cell_proliferation1.90762541
39MP0002735_abnormal_chemical_nociception1.90729293
40MP0010030_abnormal_orbit_morphology1.86914732
41MP0001501_abnormal_sleep_pattern1.84640671
42MP0004484_altered_response_of1.83481680
43MP0006035_abnormal_mitochondrial_morpho1.80183740
44MP0004130_abnormal_muscle_cell1.78160844
45MP0000490_abnormal_crypts_of1.77955618
46MP0004145_abnormal_muscle_electrophysio1.70545700
47MP0000313_abnormal_cell_death1.69769271
48MP0004085_abnormal_heartbeat1.67954989
49MP0001440_abnormal_grooming_behavior1.67087031
50MP0006292_abnormal_olfactory_placode1.67034894
51MP0009697_abnormal_copulation1.66447663
52MP0000372_irregular_coat_pigmentation1.65370814
53MP0003718_maternal_effect1.62284193
54MP0005671_abnormal_response_to1.61200638
55MP0002972_abnormal_cardiac_muscle1.59471670
56MP0005620_abnormal_muscle_contractility1.53803893
57MP0005085_abnormal_gallbladder_physiolo1.53769687
58MP0002909_abnormal_adrenal_gland1.53102212
59MP0001486_abnormal_startle_reflex1.52648984
60MP0002139_abnormal_hepatobiliary_system1.51289532
61MP0000358_abnormal_cell_content/1.50904959
62MP0009379_abnormal_foot_pigmentation1.50800389
63MP0001853_heart_inflammation1.50206110
64MP0002067_abnormal_sensory_capabilities1.49393851
65MP0002254_reproductive_system_inflammat1.46880969
66MP0002876_abnormal_thyroid_physiology1.44219541
67MP0002269_muscular_atrophy1.43813067
68MP0002734_abnormal_mechanical_nocicepti1.41170692
69MP0004924_abnormal_behavior1.40017034
70MP0005386_behavior/neurological_phenoty1.40017034
71MP0004043_abnormal_pH_regulation1.39614083
72MP0001529_abnormal_vocalization1.39165657
73MP0002019_abnormal_tumor_incidence1.38269189
74MP0004142_abnormal_muscle_tone1.38033620
75MP0001697_abnormal_embryo_size1.37651617
76MP0004087_abnormal_muscle_fiber1.37649851
77MP0002080_prenatal_lethality1.37407167
78MP0004233_abnormal_muscle_weight1.36942509
79MP0008875_abnormal_xenobiotic_pharmacok1.36280661
80MP0006276_abnormal_autonomic_nervous1.35297900
81MP0006138_congestive_heart_failure1.34925313
82MP0003329_amyloid_beta_deposits1.34777505
83MP0005360_urolithiasis1.32599942
84MP0005380_embryogenesis_phenotype1.31469880
85MP0001672_abnormal_embryogenesis/_devel1.31469880
86MP0003879_abnormal_hair_cell1.30377982
87MP0001293_anophthalmia1.29664337
88MP0003763_abnormal_thymus_physiology1.29604082
89MP0005451_abnormal_body_composition1.29003615
90MP0000747_muscle_weakness1.28194544
91MP0008775_abnormal_heart_ventricle1.24655934
92MP0003806_abnormal_nucleotide_metabolis1.22226820
93MP0002106_abnormal_muscle_physiology1.21056040
94MP0005646_abnormal_pituitary_gland1.19748555
95MP0005365_abnormal_bile_salt1.19173540
96MP0001544_abnormal_cardiovascular_syste1.18987942
97MP0005385_cardiovascular_system_phenoty1.18987942
98MP0009672_abnormal_birth_weight1.18921177
99MP0002332_abnormal_exercise_endurance1.18771973
100MP0004147_increased_porphyrin_level1.18542545
101MP0003567_abnormal_fetal_cardiomyocyte1.18442987
102MP0008569_lethality_at_weaning1.18352642
103MP0005535_abnormal_body_temperature1.17652658
104MP0009780_abnormal_chondrocyte_physiolo1.17632593
105MP0005551_abnormal_eye_electrophysiolog1.17549542
106MP0005332_abnormal_amino_acid1.16451659
107MP0010307_abnormal_tumor_latency1.11951247
108MP0001970_abnormal_pain_threshold1.10946015
109MP0002938_white_spotting1.09367149
110MP0002085_abnormal_embryonic_tissue1.08107686
111MP0002210_abnormal_sex_determination1.07955426
112MP0001727_abnormal_embryo_implantation1.07664039
113MP0003984_embryonic_growth_retardation1.07133970
114MP0003195_calcinosis1.07057686
115MP0001346_abnormal_lacrimal_gland1.05563343
116MP0002733_abnormal_thermal_nociception1.05388452
117MP0003123_paternal_imprinting1.05236566
118MP0008872_abnormal_physiological_respon1.04974883
119MP0000759_abnormal_skeletal_muscle1.03885502
120MP0005394_taste/olfaction_phenotype1.03713558
121MP0005499_abnormal_olfactory_system1.03713558
122MP0000703_abnormal_thymus_morphology1.02445128
123MP0003941_abnormal_skin_development1.02370352
124MP0002088_abnormal_embryonic_growth/wei1.01651418
125MP0002066_abnormal_motor_capabilities/c1.01158932
126MP0002557_abnormal_social/conspecific_i1.00126755
127MP0005075_abnormal_melanosome_morpholog0.99523000
128MP0008260_abnormal_autophagy0.98633357
129MP0001984_abnormal_olfaction0.98223150
130MP0003315_abnormal_perineum_morphology0.98110921
131MP0005369_muscle_phenotype0.96822361
132MP0001873_stomach_inflammation0.95427919
133MP0000013_abnormal_adipose_tissue0.95420604
134MP0000750_abnormal_muscle_regeneration0.94647561
135MP0003221_abnormal_cardiomyocyte_apopto0.94264216
136MP0008789_abnormal_olfactory_epithelium0.94058019
137MP0001905_abnormal_dopamine_level0.93916701
138MP0005266_abnormal_metabolism0.92980706
139MP0005423_abnormal_somatic_nervous0.92925569
140MP0008995_early_reproductive_senescence0.92382319
141MP0001502_abnormal_circadian_rhythm0.91806042
142MP0006072_abnormal_retinal_apoptosis0.91368419
143MP0005379_endocrine/exocrine_gland_phen0.90306136
144MP0010329_abnormal_lipoprotein_level0.89347358
145MP0002229_neurodegeneration0.88633280
146MP0000689_abnormal_spleen_morphology0.88591943
147MP0004185_abnormal_adipocyte_glucose0.88426384
148MP0002722_abnormal_immune_system0.87518127
149MP0002184_abnormal_innervation0.86875482
150MP0001764_abnormal_homeostasis0.86545227
151MP0005501_abnormal_skin_physiology0.86006553
152MP0003136_yellow_coat_color0.85997739
153MP0003633_abnormal_nervous_system0.85367661
154MP0002398_abnormal_bone_marrow0.84676090
155MP0000230_abnormal_systemic_arterial0.83875495
156MP0002429_abnormal_blood_cell0.79959598
157MP0004811_abnormal_neuron_physiology0.79220621
158MP0002078_abnormal_glucose_homeostasis0.79150589
159MP0001929_abnormal_gametogenesis0.77982104
160MP0002234_abnormal_pharynx_morphology0.77304117
161MP0008874_decreased_physiological_sensi0.77261669
162MP0001145_abnormal_male_reproductive0.76522559
163MP0003122_maternal_imprinting0.76439896
164MP0000685_abnormal_immune_system0.76288755
165MP0002882_abnormal_neuron_morphology0.75697876
166MP0001119_abnormal_female_reproductive0.75601839
167MP0001661_extended_life_span0.74559305
168MP0002111_abnormal_tail_morphology0.74432176
169MP0001919_abnormal_reproductive_system0.73731242
170MP0005670_abnormal_white_adipose0.73508296
171MP0002090_abnormal_vision0.72800037
172MP0010630_abnormal_cardiac_muscle0.72416322
173MP0002127_abnormal_cardiovascular_syste0.71407634
174MP0005384_cellular_phenotype0.71168608
175MP0005408_hypopigmentation0.70510623
176MP0000653_abnormal_sex_gland0.69384149
177MP0002084_abnormal_developmental_patter0.69006576
178MP0003937_abnormal_limbs/digits/tail_de0.66152517
179MP0002697_abnormal_eye_size0.62714381
180MP0000049_abnormal_middle_ear0.62069783
181MP0001881_abnormal_mammary_gland0.60091955
182MP0002132_abnormal_respiratory_system0.59993586
183MP0002277_abnormal_respiratory_mucosa0.58957022
184MP0002086_abnormal_extraembryonic_tissu0.58156085
185MP0000716_abnormal_immune_system0.57657050
186MP0002160_abnormal_reproductive_system0.57366745
187MP0008873_increased_physiological_sensi0.57108133
188MP0002796_impaired_skin_barrier0.54180392
189MP0004197_abnormal_fetal_growth/weight/0.54076115

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.67741236
2Acute necrotizing encephalopathy (HP:0006965)4.66150997
3Abnormal mitochondria in muscle tissue (HP:0008316)4.61356450
4Reticulocytopenia (HP:0001896)4.51711597
5Sudden death (HP:0001699)4.37530300
6Acute encephalopathy (HP:0006846)4.24317407
7Progressive macrocephaly (HP:0004481)4.02637999
8Mitochondrial inheritance (HP:0001427)3.97001143
9Hepatocellular necrosis (HP:0001404)3.83777459
10Microvesicular hepatic steatosis (HP:0001414)3.80129721
11Hepatic necrosis (HP:0002605)3.76364982
12Exercise-induced myalgia (HP:0003738)3.74489613
13Calf muscle hypertrophy (HP:0008981)3.71320094
14Increased CSF lactate (HP:0002490)3.68465971
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.67284799
16Muscle hypertrophy of the lower extremities (HP:0008968)3.58316098
17Hyperventilation (HP:0002883)3.48886223
18Cerebral edema (HP:0002181)3.48837903
19Myokymia (HP:0002411)3.42253739
20Epileptic encephalopathy (HP:0200134)3.40410790
21Atonic seizures (HP:0010819)3.35774993
22Atrial fibrillation (HP:0005110)3.27427684
23Syncope (HP:0001279)3.25026211
24Pheochromocytoma (HP:0002666)3.23946532
25Myoglobinuria (HP:0002913)3.21915120
26Colon cancer (HP:0003003)3.21481992
27Abnormal number of erythroid precursors (HP:0012131)3.18162900
28Lactic acidosis (HP:0003128)3.15240767
29Primary atrial arrhythmia (HP:0001692)3.14279631
30Neuroendocrine neoplasm (HP:0100634)3.12570126
31Abnormality of cells of the erythroid lineage (HP:0012130)3.12478910
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12252884
33Febrile seizures (HP:0002373)3.11406879
34Visual hallucinations (HP:0002367)3.11134191
35Exercise-induced muscle cramps (HP:0003710)3.10953740
36Supraventricular tachycardia (HP:0004755)3.09472330
37Absence seizures (HP:0002121)3.08334550
38Palpitations (HP:0001962)3.06209428
39Renal Fanconi syndrome (HP:0001994)3.05439835
40Focal seizures (HP:0007359)3.04211031
41Hyperalaninemia (HP:0003348)3.02935910
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02935910
43Abnormality of alanine metabolism (HP:0010916)3.02935910
44Type I transferrin isoform profile (HP:0003642)3.02339811
45Abnormality of glycolysis (HP:0004366)2.99819952
46Increased serum pyruvate (HP:0003542)2.99819952
47Supraventricular arrhythmia (HP:0005115)2.98037523
48Macrocytic anemia (HP:0001972)2.94843679
49Abnormality of the calf musculature (HP:0001430)2.88343646
50Birth length less than 3rd percentile (HP:0003561)2.86856618
51Ketoacidosis (HP:0001993)2.86446208
52Ventricular tachycardia (HP:0004756)2.83988711
53Multiple enchondromatosis (HP:0005701)2.83886552
54Dialeptic seizures (HP:0011146)2.78623803
55Increased intramyocellular lipid droplets (HP:0012240)2.71357605
56Progressive muscle weakness (HP:0003323)2.70585447
57Generalized tonic-clonic seizures (HP:0002069)2.69158427
58Increased muscle lipid content (HP:0009058)2.67382453
59Pancytopenia (HP:0001876)2.66154878
60Respiratory difficulties (HP:0002880)2.65901470
61Respiratory failure (HP:0002878)2.65890623
62Meckel diverticulum (HP:0002245)2.65316157
63Bundle branch block (HP:0011710)2.64300105
64Chromsome breakage (HP:0040012)2.64136972
65Exercise intolerance (HP:0003546)2.64063558
66Ragged-red muscle fibers (HP:0003200)2.61327546
67Abnormal gallbladder physiology (HP:0012438)2.58528832
68Cholecystitis (HP:0001082)2.58528832
69Optic disc pallor (HP:0000543)2.58524217
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.55747109
71Abnormal protein glycosylation (HP:0012346)2.54999959
72Abnormal glycosylation (HP:0012345)2.54999959
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54999959
74Abnormal protein N-linked glycosylation (HP:0012347)2.54999959
75Aplastic anemia (HP:0001915)2.54039452
76Ketosis (HP:0001946)2.53691495
77Abnormality of the ileum (HP:0001549)2.52358334
78Abnormality of the preputium (HP:0100587)2.50882588
79Prolonged QT interval (HP:0001657)2.48433593
80Increased serum lactate (HP:0002151)2.47494807
81Degeneration of anterior horn cells (HP:0002398)2.47070191
82Abnormality of the anterior horn cell (HP:0006802)2.47070191
833-Methylglutaconic aciduria (HP:0003535)2.46386042
84Dysdiadochokinesis (HP:0002075)2.45784676
85Reduced antithrombin III activity (HP:0001976)2.44915598
86Rough bone trabeculation (HP:0100670)2.41497470
87Athetosis (HP:0002305)2.38327922
88Ventricular fibrillation (HP:0001663)2.37895805
89Horseshoe kidney (HP:0000085)2.37191406
90Dysmetric saccades (HP:0000641)2.36866680
91Cleft eyelid (HP:0000625)2.34137250
92Ventricular arrhythmia (HP:0004308)2.33817591
93Rhabdomyolysis (HP:0003201)2.31493465
94Testicular atrophy (HP:0000029)2.30473036
95Lethargy (HP:0001254)2.29704823
96Cholelithiasis (HP:0001081)2.28073103
97Left ventricular hypertrophy (HP:0001712)2.27782212
98Lipid accumulation in hepatocytes (HP:0006561)2.27205177
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.24814206
100Lipoatrophy (HP:0100578)2.24321182
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23940503
102Dicarboxylic aciduria (HP:0003215)2.23940503
103Abnormal EKG (HP:0003115)2.23473498
104Exertional dyspnea (HP:0002875)2.23394369
105Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22409016
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22409016
107Heart block (HP:0012722)2.22258999
108Microretrognathia (HP:0000308)2.21449052
109Anxiety (HP:0000739)2.20783664
110Myotonia (HP:0002486)2.19287085
111Abnormality of fatty-acid metabolism (HP:0004359)2.18478441
112Leukodystrophy (HP:0002415)2.16806391
113Status epilepticus (HP:0002133)2.15962995
114Conjunctival hamartoma (HP:0100780)2.13882324
115Broad-based gait (HP:0002136)2.13091551
116Abnormality of methionine metabolism (HP:0010901)2.11637789
117Abnormal gallbladder morphology (HP:0012437)2.10945923
118Central scotoma (HP:0000603)2.10859389
119Increased hepatocellular lipid droplets (HP:0006565)2.09342743
120Dilated cardiomyopathy (HP:0001644)2.07820808
121Hyperammonemia (HP:0001987)2.07414605
122EMG: myopathic abnormalities (HP:0003458)2.06898730
123Abnormal social behavior (HP:0012433)2.06186996
124Impaired social interactions (HP:0000735)2.06186996
125Absent thumb (HP:0009777)2.06064723
126IgM deficiency (HP:0002850)2.05732691
127Atrioventricular block (HP:0001678)2.05492478
128Poor eye contact (HP:0000817)2.03547363
129Pallor (HP:0000980)2.03231248
130Unsteady gait (HP:0002317)2.02751592
131Hyperglycinemia (HP:0002154)2.02565049
132Hypoglycemic coma (HP:0001325)2.01585091
133Cellular immunodeficiency (HP:0005374)2.00600104
134Abnormality of chromosome stability (HP:0003220)2.00216439
135CNS demyelination (HP:0007305)2.00107338
136Abnormal trabecular bone morphology (HP:0100671)1.99947651
137Emotional lability (HP:0000712)1.99511804
138Facial cleft (HP:0002006)1.99399641
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98971525
140Progressive inability to walk (HP:0002505)1.98118950
141Methylmalonic aciduria (HP:0012120)1.97225674
142Abnormal atrioventricular conduction (HP:0005150)1.95642150
143Metabolic acidosis (HP:0001942)1.94822817
144Abnormal lung lobation (HP:0002101)1.94235459
145Progressive cerebellar ataxia (HP:0002073)1.92013529
146Squamous cell carcinoma (HP:0002860)1.90818236
147Oral leukoplakia (HP:0002745)1.86589351
148Abnormality of reticulocytes (HP:0004312)1.86096158
149Small intestinal stenosis (HP:0012848)1.86089932
150Duodenal stenosis (HP:0100867)1.86089932
151Carpal bone hypoplasia (HP:0001498)1.85876176
152Secondary amenorrhea (HP:0000869)1.85806669
153Abnormality of the labia minora (HP:0012880)1.84747272
154Abnormality of serum amino acid levels (HP:0003112)1.82258792
155Selective tooth agenesis (HP:0001592)1.81615800
156Progressive external ophthalmoplegia (HP:0000590)1.77429823
157Absent radius (HP:0003974)1.76457079
158Abnormality of the umbilical cord (HP:0010881)1.76200790
159Generalized aminoaciduria (HP:0002909)1.75081403
160Sparse eyelashes (HP:0000653)1.74387448
161Cerebral hypomyelination (HP:0006808)1.74203837
162Triphalangeal thumb (HP:0001199)1.73663307
163Hypoplasia of the pons (HP:0012110)1.71973924
164Poor head control (HP:0002421)1.71560965
165Myelodysplasia (HP:0002863)1.70357082
166Postnatal microcephaly (HP:0005484)1.68253430
167Nausea (HP:0002018)1.65417050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.36886426
2BUB15.01478301
3NME24.22017679
4MAP3K43.66822027
5CDC73.50757869
6EPHA43.46164405
7NTRK33.38918123
8MAP2K73.34712887
9SRPK13.05408957
10MAP3K122.97098792
11CASK2.93265452
12PDK42.65622432
13PDK32.65622432
14MAP2K42.64487185
15ZAK2.57669558
16VRK12.56866048
17TESK22.44889629
18MYLK2.25376648
19PBK2.24423596
20NEK12.19823473
21MUSK2.19210801
22TTK2.15179707
23NME12.14498065
24PRPF4B2.05136331
25EIF2AK12.01458379
26BCKDK2.00993587
27KDR2.00037283
28PHKG21.99974636
29PHKG11.99974636
30MAP3K91.99212416
31DAPK11.98231025
32SMG11.98176303
33PINK11.91992731
34LMTK21.86245623
35PLK41.85113228
36MST41.80769489
37DAPK21.79723125
38OBSCN1.68036112
39CAMKK21.67802206
40TAF11.66221711
41TTN1.62863036
42PLK31.52662285
43ARAF1.52081994
44PLK21.48233637
45WEE11.47124074
46TLK11.45504877
47EIF2AK31.43722411
48TRIM281.41720626
49MINK11.41688941
50IRAK31.38692570
51PDK21.37926194
52GRK51.36049668
53PLK11.34992701
54KSR21.31714848
55CAMK2A1.30833354
56CDK191.29316428
57CHEK21.26218584
58AURKA1.20872110
59PRKCG1.20650686
60PASK1.20501212
61CDK81.17402654
62AKT31.16293518
63AURKB1.15076541
64CCNB11.14351391
65CAMK2D1.13999875
66ATR1.13973101
67TNIK1.13759566
68RIPK41.09761811
69PNCK1.08054361
70PAK41.06961904
71CAMKK11.06795902
72CDK71.02821258
73GRK71.01624096
74STK41.00910165
75PIM20.99564924
76CAMK2B0.99564017
77TESK10.98212054
78TAOK20.97057248
79KSR10.95554755
80STK380.92309563
81CAMK10.91606807
82TSSK60.89034222
83CSNK1G30.88081912
84PTK2B0.87538161
85PAK60.86941671
86MAP3K80.85824159
87BRAF0.82927387
88SCYL20.82846999
89NTRK20.82241764
90CDK50.81608914
91CAMK2G0.81454668
92MKNK10.79985267
93CHEK10.79355958
94MAPK120.78501208
95MARK10.77236178
96RPS6KA50.76936589
97RPS6KA40.76679814
98LIMK10.76322474
99PAK30.76176327
100EIF2AK20.75267423
101CDK40.74735565
102NUAK10.74104492
103PIK3CA0.72457743
104DAPK30.70884392
105MAP3K130.69644541
106DYRK20.69581541
107PRKCE0.69108920
108PDPK10.68855400
109STK100.68274831
110INSRR0.67600359
111BRSK20.66880517
112CSNK1A1L0.65162312
113CDK30.64966655
114CSNK1G10.64494108
115MAP3K10.64080299
116OXSR10.62139696
117WNK40.62031976
118CLK10.61620776
119CSNK2A10.61579673
120WNK30.61522612
121SGK20.60812273
122CSNK2A20.60615211
123PAK10.60504395
124RAF10.59030598
125ILK0.57342344
126DYRK30.57325091
127PRKD30.56984640
128MAP3K100.56734343
129NTRK10.56614593
130LRRK20.56416206
131MAP3K70.56004470
132RPS6KB20.55393116
133STK160.54223471
134PRKACA0.53990254
135SGK2230.52426167
136SGK4940.52426167
137PDK10.52055728
138CAMK40.51717550
139MKNK20.49920738
140BCR0.49567414
141BMPR20.49191044
142MAP3K110.47279879
143FES0.47219637
144STK240.46433371
145NEK20.46163490
146SGK10.46117618
147CDC42BPA0.44630796
148ALK0.44411061
149EPHA30.44247097
150IRAK40.44002284
151MAP3K50.43864698
152BRSK10.43752111
153STK38L0.43497443
154ATM0.43456523
155CSNK1G20.43033385
156ERBB40.41969097
157PKN20.41414439
158PRKAA10.40541409
159MAP4K20.40029657
160PRKD10.38166821
161PRKCI0.37111778
162RPS6KA30.37068696
163PRKACG0.35833090
164PRKACB0.35598705
165CDK180.35580392
166PIM10.35121549
167CDK11A0.35061303
168CDK20.34834650
169ABL20.34761725
170GRK60.34609655
171PRKCA0.34469004
172STK110.34262751
173CDK150.33397084
174CDK10.31824341
175AKT20.31234545
176CDK140.28787631
177MAP4K10.28037872
178EPHA20.27919829
179CDK90.26208983
180SIK30.23515568
181MAPKAPK50.20209036

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.49328959
2DNA replication_Homo sapiens_hsa030304.21598024
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.04202123
4Ribosome_Homo sapiens_hsa030103.85329723
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.52532864
6Oxidative phosphorylation_Homo sapiens_hsa001903.46912837
7Mismatch repair_Homo sapiens_hsa034303.45618930
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.96626923
9Nicotine addiction_Homo sapiens_hsa050332.89951170
10Parkinsons disease_Homo sapiens_hsa050122.86233383
11Base excision repair_Homo sapiens_hsa034102.82532886
12Cardiac muscle contraction_Homo sapiens_hsa042602.66148186
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63934974
14RNA polymerase_Homo sapiens_hsa030202.61852226
15Spliceosome_Homo sapiens_hsa030402.43478526
16Homologous recombination_Homo sapiens_hsa034402.38533251
17Alzheimers disease_Homo sapiens_hsa050102.38243015
18Synaptic vesicle cycle_Homo sapiens_hsa047212.32295149
19Propanoate metabolism_Homo sapiens_hsa006402.18682322
20Pyruvate metabolism_Homo sapiens_hsa006202.14783650
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10082582
22Pyrimidine metabolism_Homo sapiens_hsa002402.09074744
23Sulfur relay system_Homo sapiens_hsa041222.00882597
24Collecting duct acid secretion_Homo sapiens_hsa049661.97020861
25Nucleotide excision repair_Homo sapiens_hsa034201.93661154
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93598298
27One carbon pool by folate_Homo sapiens_hsa006701.92577696
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90977641
29Huntingtons disease_Homo sapiens_hsa050161.89827684
30Non-homologous end-joining_Homo sapiens_hsa034501.87403416
31Carbon metabolism_Homo sapiens_hsa012001.84748957
32GABAergic synapse_Homo sapiens_hsa047271.83525807
33RNA transport_Homo sapiens_hsa030131.79376746
34Fanconi anemia pathway_Homo sapiens_hsa034601.70821469
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66937229
36Long-term potentiation_Homo sapiens_hsa047201.64636239
37Protein export_Homo sapiens_hsa030601.64160730
38Cell cycle_Homo sapiens_hsa041101.59595296
39Morphine addiction_Homo sapiens_hsa050321.59355859
40Circadian entrainment_Homo sapiens_hsa047131.57433459
41Olfactory transduction_Homo sapiens_hsa047401.56035539
42Butanoate metabolism_Homo sapiens_hsa006501.55867291
43Fatty acid degradation_Homo sapiens_hsa000711.52855261
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51527299
45Glutamatergic synapse_Homo sapiens_hsa047241.49143662
46Amphetamine addiction_Homo sapiens_hsa050311.47954481
47RNA degradation_Homo sapiens_hsa030181.42645185
48Arginine biosynthesis_Homo sapiens_hsa002201.39854152
49Insulin secretion_Homo sapiens_hsa049111.28128453
50Taste transduction_Homo sapiens_hsa047421.28026687
51Calcium signaling pathway_Homo sapiens_hsa040201.26235593
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26222538
53Fatty acid metabolism_Homo sapiens_hsa012121.24379954
54Dilated cardiomyopathy_Homo sapiens_hsa054141.24178418
55Purine metabolism_Homo sapiens_hsa002301.22923874
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22874240
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.20393247
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19525002
59Folate biosynthesis_Homo sapiens_hsa007901.17957968
60Biosynthesis of amino acids_Homo sapiens_hsa012301.17728638
61Vitamin B6 metabolism_Homo sapiens_hsa007501.17592359
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17016165
63Glutathione metabolism_Homo sapiens_hsa004801.16703036
64Salivary secretion_Homo sapiens_hsa049701.16215965
65Pentose phosphate pathway_Homo sapiens_hsa000301.15168769
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14855399
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.07838801
68Renin secretion_Homo sapiens_hsa049241.07063563
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07054513
70Dopaminergic synapse_Homo sapiens_hsa047281.06692725
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05730956
72Basal transcription factors_Homo sapiens_hsa030221.04328342
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04189015
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02287679
75Primary immunodeficiency_Homo sapiens_hsa053401.02101117
76Systemic lupus erythematosus_Homo sapiens_hsa053221.00720449
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99283141
78Fatty acid elongation_Homo sapiens_hsa000620.97848176
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97695381
80Oxytocin signaling pathway_Homo sapiens_hsa049210.94910303
81Vibrio cholerae infection_Homo sapiens_hsa051100.94853835
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94506547
83Gastric acid secretion_Homo sapiens_hsa049710.93063885
84Serotonergic synapse_Homo sapiens_hsa047260.90536207
85Glucagon signaling pathway_Homo sapiens_hsa049220.87745090
86Steroid biosynthesis_Homo sapiens_hsa001000.86722195
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85943814
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82267551
89beta-Alanine metabolism_Homo sapiens_hsa004100.78931651
90Phenylalanine metabolism_Homo sapiens_hsa003600.78822864
91mRNA surveillance pathway_Homo sapiens_hsa030150.77532369
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77527333
93p53 signaling pathway_Homo sapiens_hsa041150.77385184
94N-Glycan biosynthesis_Homo sapiens_hsa005100.76833603
95Peroxisome_Homo sapiens_hsa041460.76296883
96Fructose and mannose metabolism_Homo sapiens_hsa000510.76234191
97Epstein-Barr virus infection_Homo sapiens_hsa051690.74889611
98Tryptophan metabolism_Homo sapiens_hsa003800.72341228
99Cholinergic synapse_Homo sapiens_hsa047250.71513166
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71276466
101Bile secretion_Homo sapiens_hsa049760.69097030
102Selenocompound metabolism_Homo sapiens_hsa004500.64607309
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62750625
104Long-term depression_Homo sapiens_hsa047300.61244580
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.60657152
106Type II diabetes mellitus_Homo sapiens_hsa049300.60326345
107PPAR signaling pathway_Homo sapiens_hsa033200.59998845
108Sulfur metabolism_Homo sapiens_hsa009200.58528140
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56772105
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54992287
111cAMP signaling pathway_Homo sapiens_hsa040240.54534962
112Starch and sucrose metabolism_Homo sapiens_hsa005000.50893857
113Metabolic pathways_Homo sapiens_hsa011000.50442647
114GnRH signaling pathway_Homo sapiens_hsa049120.49680549
115Arginine and proline metabolism_Homo sapiens_hsa003300.49265549
116Circadian rhythm_Homo sapiens_hsa047100.49165996
117Nitrogen metabolism_Homo sapiens_hsa009100.48860665
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.48824154
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46072016
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45321542
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44846672
122Gap junction_Homo sapiens_hsa045400.44617417
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44283436
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.44256903
125Phototransduction_Homo sapiens_hsa047440.43744166
126Tyrosine metabolism_Homo sapiens_hsa003500.42300097
127Viral carcinogenesis_Homo sapiens_hsa052030.42277885
128Alcoholism_Homo sapiens_hsa050340.41573715
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40292659
130Galactose metabolism_Homo sapiens_hsa000520.39813805
131Insulin signaling pathway_Homo sapiens_hsa049100.39184711
132Antigen processing and presentation_Homo sapiens_hsa046120.38702541
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38352504
134Cocaine addiction_Homo sapiens_hsa050300.38200920
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37778727
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36608944
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36510240
138Herpes simplex infection_Homo sapiens_hsa051680.35720611
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35476580
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34452981
141Pancreatic secretion_Homo sapiens_hsa049720.33282774
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32267927
143Oocyte meiosis_Homo sapiens_hsa041140.31778613
144Fatty acid biosynthesis_Homo sapiens_hsa000610.29247991
145HTLV-I infection_Homo sapiens_hsa051660.27206273
146Glycerolipid metabolism_Homo sapiens_hsa005610.26487103
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.25230638
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24936393
149Shigellosis_Homo sapiens_hsa051310.24796318
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.23703021
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23005282
152ABC transporters_Homo sapiens_hsa020100.21797508
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21620870
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21461941
155Fat digestion and absorption_Homo sapiens_hsa049750.20603248
156Legionellosis_Homo sapiens_hsa051340.16966763
157NF-kappa B signaling pathway_Homo sapiens_hsa040640.13874360
158Apoptosis_Homo sapiens_hsa042100.11925293
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09173167
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06621166
161Bladder cancer_Homo sapiens_hsa052190.06039223
162HIF-1 signaling pathway_Homo sapiens_hsa040660.04992264
163Allograft rejection_Homo sapiens_hsa053300.04879849
164Basal cell carcinoma_Homo sapiens_hsa052170.04442742

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