MTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.02914747
2axon ensheathment in central nervous system (GO:0032291)6.71477449
3central nervous system myelination (GO:0022010)6.71477449
4fusion of sperm to egg plasma membrane (GO:0007342)6.64171986
5multicellular organism reproduction (GO:0032504)6.51666507
6cilium or flagellum-dependent cell motility (GO:0001539)6.05711569
7axonemal dynein complex assembly (GO:0070286)6.01379956
8negative regulation of inclusion body assembly (GO:0090084)5.89451462
9male meiosis (GO:0007140)5.82924714
10sperm motility (GO:0030317)5.76784162
11regulation of podosome assembly (GO:0071801)5.73427066
12reproduction (GO:0000003)5.39287280
13synaptonemal complex organization (GO:0070193)5.35179384
14acrosome reaction (GO:0007340)5.32448746
15synaptonemal complex assembly (GO:0007130)5.32243501
16positive regulation of chemokine biosynthetic process (GO:0045080)5.30194316
17response to peptidoglycan (GO:0032494)5.24690355
18regulation of cilium movement (GO:0003352)5.20153873
19negative regulation of interleukin-12 production (GO:0032695)5.06697243
20acrosome assembly (GO:0001675)5.04390319
21regulation of chronic inflammatory response (GO:0002676)5.02795988
22epithelial cilium movement (GO:0003351)5.02517233
23sperm-egg recognition (GO:0035036)4.96790025
24positive regulation by symbiont of host defense response (GO:0052509)4.91848473
25modulation by symbiont of host defense response (GO:0052031)4.91848473
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.91848473
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.91848473
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.91848473
29modulation by symbiont of host immune response (GO:0052553)4.91848473
30plasma membrane fusion (GO:0045026)4.83094568
31cell wall macromolecule metabolic process (GO:0044036)4.81671742
32cell wall macromolecule catabolic process (GO:0016998)4.81671742
33spermatid development (GO:0007286)4.76649243
34negative regulation of T-helper cell differentiation (GO:0045623)4.75046126
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.75046126
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.69495523
37macrophage activation involved in immune response (GO:0002281)4.61117246
38cell-cell recognition (GO:0009988)4.58764776
39male meiosis I (GO:0007141)4.58646532
40regulation of vitamin D biosynthetic process (GO:0060556)4.58420818
41DNA methylation involved in gamete generation (GO:0043046)4.57811010
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.55599338
43cilium movement (GO:0003341)4.51766359
44defense response to protozoan (GO:0042832)4.46581734
45regulation of chemokine biosynthetic process (GO:0045073)4.45775786
46response to protozoan (GO:0001562)4.32357590
47motile cilium assembly (GO:0044458)4.27321717
48monoubiquitinated protein deubiquitination (GO:0035520)4.24892065
49positive regulation of gamma-delta T cell activation (GO:0046645)4.20441061
50meiotic cell cycle (GO:0051321)4.18805103
51fertilization (GO:0009566)4.18612205
52binding of sperm to zona pellucida (GO:0007339)4.17495947
53single fertilization (GO:0007338)4.15674549
54regulation of interferon-beta biosynthetic process (GO:0045357)4.12487742
55ensheathment of neurons (GO:0007272)4.10956624
56axon ensheathment (GO:0008366)4.10956624
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.10766849
58T-helper cell differentiation (GO:0042093)4.01126983
59CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.01126983
60protein polyglutamylation (GO:0018095)4.00655749
61myelination (GO:0042552)3.99916656
62meiosis I (GO:0007127)3.94641246
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.94305970
64regulation of RNA export from nucleus (GO:0046831)3.90736193
65sperm capacitation (GO:0048240)3.88850536
66microtubule severing (GO:0051013)3.88459413
67negative regulation of neurotransmitter secretion (GO:0046929)3.87728333
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.84122307
69regulation of MHC class II biosynthetic process (GO:0045346)3.83180440
70fatty acid elongation (GO:0030497)3.80884570
71neutrophil activation involved in immune response (GO:0002283)3.79781086
72meiotic nuclear division (GO:0007126)3.77969142
73centriole replication (GO:0007099)3.76904973
74photoreceptor cell differentiation (GO:0046530)3.74109975
75eye photoreceptor cell differentiation (GO:0001754)3.74109975
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73624610
77protein K11-linked deubiquitination (GO:0035871)3.71316663
78cellular extravasation (GO:0045123)3.69879071
79positive regulation of isotype switching (GO:0045830)3.68934308
80regulation of interferon-alpha production (GO:0032647)3.65046407
81immunoglobulin mediated immune response (GO:0016064)3.62696888
82germinal center formation (GO:0002467)3.61597661
83regulation of nucleobase-containing compound transport (GO:0032239)3.57036617
84regulation of inclusion body assembly (GO:0090083)3.55615513
85spermatogenesis (GO:0007283)3.55577636
86male gamete generation (GO:0048232)3.54240500
87detection of molecule of bacterial origin (GO:0032490)3.53557603
88glycerophospholipid catabolic process (GO:0046475)3.49488617
89detection of other organism (GO:0098543)3.48646436
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48299219
91response to host immune response (GO:0052572)3.48299219
92regulation of T-helper cell differentiation (GO:0045622)3.48210448
93gamete generation (GO:0007276)3.47374117
94negative regulation of nitric oxide biosynthetic process (GO:0045019)3.43750525
95regulation of immunoglobulin secretion (GO:0051023)3.42708281
96leukocyte aggregation (GO:0070486)3.40012761
97regulation of vitamin metabolic process (GO:0030656)3.39233890
98alpha-beta T cell differentiation involved in immune response (GO:0002293)3.39053001
99alpha-beta T cell activation involved in immune response (GO:0002287)3.39053001
100T cell differentiation involved in immune response (GO:0002292)3.39053001
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.38900584
102positive regulation of interferon-alpha production (GO:0032727)3.38424616
103negative regulation of cell killing (GO:0031342)3.38277911
104negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38277911
105T-helper 1 type immune response (GO:0042088)3.35682799
106positive regulation of interleukin-10 production (GO:0032733)3.32393593
107response to methylmercury (GO:0051597)3.28609511
108long-chain fatty acid biosynthetic process (GO:0042759)3.28412956
109negative regulation of alpha-beta T cell activation (GO:0046636)3.27418829
110cellular response to type I interferon (GO:0071357)3.26141322
111type I interferon signaling pathway (GO:0060337)3.26141322
112NIK/NF-kappaB signaling (GO:0038061)3.25676558
113microglial cell activation (GO:0001774)3.25141383
114protein localization to endosome (GO:0036010)3.25076077
115chromosome organization involved in meiosis (GO:0070192)3.23453501
116response to type I interferon (GO:0034340)3.23002099
117regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.22220078
118regulation of microtubule-based movement (GO:0060632)3.21313430
119positive regulation of DNA recombination (GO:0045911)3.20372353
120macrophage activation (GO:0042116)3.20361849
121response to muramyl dipeptide (GO:0032495)3.18890911
122response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18888225
123response to host (GO:0075136)3.18888225
124response to host defenses (GO:0052200)3.18888225
125positive regulation of granulocyte differentiation (GO:0030854)3.18830089
126cytokine production involved in immune response (GO:0002367)3.18711472
127positive regulation of NF-kappaB import into nucleus (GO:0042346)3.17542960
128microtubule polymerization or depolymerization (GO:0031109)3.17090349
129positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.16825592
130regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.16825592
131granulocyte activation (GO:0036230)3.16736259
132regulation of gamma-delta T cell activation (GO:0046643)3.15987707
133detection of bacterium (GO:0016045)3.15729232
134positive regulation of mRNA 3-end processing (GO:0031442)3.14863047
135regulation of isotype switching to IgG isotypes (GO:0048302)3.14597024
136negative regulation of alpha-beta T cell differentiation (GO:0046639)3.11540737
137interferon-gamma-mediated signaling pathway (GO:0060333)3.10536600
138detection of external biotic stimulus (GO:0098581)3.07864394
139gene silencing by RNA (GO:0031047)3.06900032
140cytoplasmic mRNA processing body assembly (GO:0033962)3.06455576
141regulation of T-helper 1 cell differentiation (GO:0045625)3.06367605
142myeloid cell activation involved in immune response (GO:0002275)3.06266868
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05812135
144positive regulation of B cell proliferation (GO:0030890)3.05654949
145regulation of meiosis I (GO:0060631)3.05419774
146regulation of T-helper 2 cell differentiation (GO:0045628)3.05123036
147ventricular system development (GO:0021591)3.04603033
148positive regulation of B cell mediated immunity (GO:0002714)3.04501312
149positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04501312
150positive regulation of toll-like receptor signaling pathway (GO:0034123)3.04050827
151neutrophil activation (GO:0042119)3.02589561
152regulation of isotype switching (GO:0045191)3.02347646
153regulation of interleukin-8 biosynthetic process (GO:0045414)3.02047753
154positive regulation of type 2 immune response (GO:0002830)3.01825449
155positive regulation of immunoglobulin production (GO:0002639)3.01159897
156creatine metabolic process (GO:0006600)3.01085155
157myelin maintenance (GO:0043217)3.00848553
158T cell lineage commitment (GO:0002360)2.99973995
159cellular response to arsenic-containing substance (GO:0071243)2.98976197
160T cell activation involved in immune response (GO:0002286)2.98474721
161regulation of DNA methylation (GO:0044030)2.97176217
162CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.97149987
163production of molecular mediator involved in inflammatory response (GO:0002532)2.96834024
164regulation of mRNA 3-end processing (GO:0031440)2.96312740
165microtubule depolymerization (GO:0007019)2.96225339
166production of molecular mediator of immune response (GO:0002440)2.94916023
167regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.94091157
168positive regulation of interferon-beta production (GO:0032728)2.93928037
169antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93581615
170regulation of exit from mitosis (GO:0007096)2.93249497
171negative regulation of cytokine production involved in immune response (GO:0002719)2.92791045
172cellular process involved in reproduction in multicellular organism (GO:0022412)2.92640200
173positive regulation of cytokine biosynthetic process (GO:0042108)2.92311300
174sphingosine metabolic process (GO:0006670)2.90862386
175regulation of interleukin-12 production (GO:0032655)2.89271780
176neutrophil mediated immunity (GO:0002446)2.88851588
177centriole assembly (GO:0098534)2.84337104
178germ cell development (GO:0007281)2.84046893
179female gamete generation (GO:0007292)2.83269544
180negative regulation of organelle assembly (GO:1902116)2.83101594
181positive regulation of macroautophagy (GO:0016239)2.76450301
182negative regulation of neurotransmitter transport (GO:0051589)2.72332473
183asymmetric protein localization (GO:0008105)2.68682470
184positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.67037282
185regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.67037282
186regulation of cilium assembly (GO:1902017)2.66522450
187multicellular organismal reproductive process (GO:0048609)2.64068146
188regulation of spindle checkpoint (GO:0090231)2.63642168
189mitochondrion degradation (GO:0000422)2.63434415
190positive regulation of chromosome segregation (GO:0051984)2.60500344
191oligodendrocyte differentiation (GO:0048709)2.60242391
192labyrinthine layer development (GO:0060711)2.60154863
193cellular response to gamma radiation (GO:0071480)2.59297242
194regulation of meiosis (GO:0040020)2.59271836
195positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.58634041
196apical protein localization (GO:0045176)2.58433807
197protein palmitoylation (GO:0018345)2.57592038
198amyloid precursor protein metabolic process (GO:0042982)2.55980602
199inner cell mass cell proliferation (GO:0001833)2.54372568
200spermatid nucleus differentiation (GO:0007289)2.51091292

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.73152875
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.02048354
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.66748829
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.22800298
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.74738112
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73815236
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.69539806
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65284572
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56435183
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31974512
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.23564346
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20933171
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19223426
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.15549364
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15030886
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02981187
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.96399289
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83905738
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.78720994
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49319382
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.48394733
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41338644
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38938400
24* VDR_24787735_ChIP-Seq_THP-1_Human2.36382607
25* VDR_24763502_ChIP-Seq_THP-1_Human2.19834753
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18053689
27RUNX_20019798_ChIP-Seq_JUKART_Human2.16879391
28* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.16808734
29* SPI1_23127762_ChIP-Seq_K562_Human2.16359366
30* SPI1_23547873_ChIP-Seq_NB4_Human2.15456120
31MYB_26560356_Chip-Seq_TH2_Human2.11348220
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97194977
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96356595
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95859599
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85860332
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85350392
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.83376876
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.83357779
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.77079897
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75369714
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.75185212
42* MAF_26560356_Chip-Seq_TH1_Human1.73116736
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68336613
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66534923
45* VDR_21846776_ChIP-Seq_THP-1_Human1.65776481
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64066931
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60980053
48MYB_26560356_Chip-Seq_TH1_Human1.59324798
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56549633
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.55207587
51SCL_19346495_ChIP-Seq_HPC-7_Human1.50932128
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50227655
53PU_27001747_Chip-Seq_BMDM_Mouse1.46143497
54FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46000482
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45074759
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41478633
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.37433223
58TCF7_22412390_ChIP-Seq_EML_Mouse1.37046813
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33875272
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32578447
61STAT1_17558387_ChIP-Seq_HELA_Human1.32413465
62* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.31894328
63* NFYB_21822215_ChIP-Seq_K562_Human1.31272782
64MYC_22102868_ChIP-Seq_BL_Human1.31019833
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30319311
66* TBL1_22424771_ChIP-Seq_293T_Human1.29837284
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29689329
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.29675687
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28980685
70* UTX_26944678_Chip-Seq_JUKART_Human1.28518296
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28365055
72GATA1_19941826_ChIP-Seq_K562_Human1.28270420
73GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.28238915
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27143778
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25917345
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25795592
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25741879
78GATA1_19941827_ChIP-Seq_MEL86_Mouse1.24217754
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24011722
80* PHF8_20622853_ChIP-Seq_HELA_Human1.23144882
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22716567
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22492300
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.21945286
84GATA3_27048872_Chip-Seq_THYMUS_Human1.20790588
85RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19608474
86VDR_22108803_ChIP-Seq_LS180_Human1.19470544
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.19211851
88GF1_26923725_Chip-Seq_HPCs_Mouse1.19113083
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19109195
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19056060
91AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18252820
92KDM2B_26808549_Chip-Seq_DND41_Human1.17859268
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17411878
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17228633
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17219379
96GATA1_22025678_ChIP-Seq_K562_Human1.16781059
97* NFYA_21822215_ChIP-Seq_K562_Human1.16712916
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15842123
99* MAF_26560356_Chip-Seq_TH2_Human1.13717836
100TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12223728
101GATA3_26560356_Chip-Seq_TH1_Human1.11907334
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11891854
103* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11769883
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11664211
105* GATA6_21074721_ChIP-Seq_CACO-2_Human1.10181979
106TFEB_21752829_ChIP-Seq_HELA_Human1.09732584
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09684873
108* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09640731
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08873532
110* HNFA_21074721_ChIP-Seq_CACO-2_Human1.08413701
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.08030883
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07509678
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07062312
114KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06966877
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06841946
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06593548
117GATA3_21867929_ChIP-Seq_TH1_Mouse1.05232668
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05031588
119SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04202481
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04157170
121SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03696610
122* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03664646
123FOXA1_25552417_ChIP-Seq_VCAP_Human1.03361229
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.03199617
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03008071
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02838985
127* NANOG_20526341_ChIP-Seq_ESCs_Human1.02596866
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01688699
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01345014
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.00801631
131STAT3_23295773_ChIP-Seq_U87_Human1.00649120
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.99259093
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.99144177
134* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98054607
135CDX2_22108803_ChIP-Seq_LS180_Human0.97977484
136LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.97675020
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96955472
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95614300
139CBP_21632823_ChIP-Seq_H3396_Human0.95437200
140SMRT_27268052_Chip-Seq_Bcells_Human0.95420235
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.94988544
142KLF4_18555785_Chip-Seq_ESCs_Mouse0.94565292
143LXR_22158963_ChIP-Seq_LIVER_Mouse0.94516326
144* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94468380
145* RBPJ_21746931_ChIP-Seq_IB4_Human0.94463973
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94415393
147* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94138887
148* ETV1_20927104_ChIP-Seq_GIST48_Human0.93661901
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93330179
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92511337
151* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92420965
152SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92384057
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92384057
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.92146095
155* GATA3_26560356_Chip-Seq_TH2_Human0.92115712
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92061367
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91817045
158GATA2_19941826_ChIP-Seq_K562_Human0.91348635
159OCT1_27270436_Chip-Seq_PROSTATE_Human0.90708537
160GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90179582
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89883965
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89540374
163SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89284335
164ESET_19884257_ChIP-Seq_ESCs_Mouse0.88393269
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.88297097
166TAL1_26923725_Chip-Seq_HPCs_Mouse0.87927886
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87759151
168CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87100026
169SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86821922
170GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86417446
171SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85609565
172KLF4_19829295_ChIP-Seq_ESCs_Human0.85269879
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84625093
174TCF4_23295773_ChIP-Seq_U87_Human0.84582245
175STAT1_20625510_ChIP-Seq_HELA_Human0.83941448
176ER_23166858_ChIP-Seq_MCF-7_Human0.83059712
177FOXA2_19822575_ChIP-Seq_HepG2_Human0.82985387
178Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82755254
179ESR2_21235772_ChIP-Seq_MCF-7_Human0.82734682
180FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81506533
181ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81060533
182* ELK3_25401928_ChIP-Seq_HUVEC_Human0.78957937
183ESR1_20079471_ChIP-ChIP_T-47D_Human0.76099350
184* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75943100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.86086997
2MP0008877_abnormal_DNA_methylation4.11844211
3MP0003950_abnormal_plasma_membrane3.77318797
4MP0001835_abnormal_antigen_presentation3.71262802
5MP0003436_decreased_susceptibility_to3.61368537
6MP0001929_abnormal_gametogenesis3.59480806
7MP0003724_increased_susceptibility_to3.52632120
8MP0009785_altered_susceptibility_to3.16525668
9MP0003698_abnormal_male_reproductive3.12629464
10MP0002148_abnormal_hypersensitivity_rea3.03398644
11MP0002877_abnormal_melanocyte_morpholog2.94186189
12MP0000920_abnormal_myelination2.86304499
13MP0001790_abnormal_immune_system2.85253810
14MP0005387_immune_system_phenotype2.85253810
15MP0005000_abnormal_immune_tolerance2.78629527
16MP0002419_abnormal_innate_immunity2.75020504
17MP0005451_abnormal_body_composition2.71667814
18MP0002653_abnormal_ependyma_morphology2.68649558
19MP0003718_maternal_effect2.68390835
20MP0004185_abnormal_adipocyte_glucose2.66969696
21MP0005025_abnormal_response_to2.62163449
22MP0003656_abnormal_erythrocyte_physiolo2.53511304
23MP0001800_abnormal_humoral_immune2.50554522
24MP0005671_abnormal_response_to2.49432823
25MP0008057_abnormal_DNA_replication2.44124725
26MP0005310_abnormal_salivary_gland2.40857721
27MP0002210_abnormal_sex_determination2.40097130
28MP0003300_gastrointestinal_ulcer2.35260299
29MP0000685_abnormal_immune_system2.34117082
30MP0002452_abnormal_antigen_presenting2.32712373
31MP0002723_abnormal_immune_serum2.30729263
32MP0001145_abnormal_male_reproductive2.15000897
33MP0000653_abnormal_sex_gland2.06578918
34MP0009764_decreased_sensitivity_to2.06569518
35MP0002161_abnormal_fertility/fecundity2.03937766
36MP0004947_skin_inflammation2.02383841
37MP0009278_abnormal_bone_marrow1.97550971
38MP0002420_abnormal_adaptive_immunity1.97100781
39MP0001819_abnormal_immune_cell1.95918562
40MP0001873_stomach_inflammation1.90260751
41MP0001533_abnormal_skeleton_physiology1.88567949
42MP0003172_abnormal_lysosome_physiology1.85401344
43MP0001851_eye_inflammation1.84066559
44MP0002405_respiratory_system_inflammati1.82260235
45MP0009840_abnormal_foam_cell1.81737904
46MP0003191_abnormal_cellular_cholesterol1.81599977
47MP0004270_analgesia1.75867492
48MP0001845_abnormal_inflammatory_respons1.71415439
49MP0008260_abnormal_autophagy1.71104036
50MP0010155_abnormal_intestine_physiology1.63798408
51MP0005397_hematopoietic_system_phenotyp1.55758409
52MP0001545_abnormal_hematopoietic_system1.55758409
53MP0001853_heart_inflammation1.54892178
54MP0008469_abnormal_protein_level1.53655095
55MP0002229_neurodegeneration1.51956101
56MP0002332_abnormal_exercise_endurance1.50689238
57MP0002138_abnormal_hepatobiliary_system1.49755353
58MP0003075_altered_response_to1.48128899
59MP0008004_abnormal_stomach_pH1.47827800
60MP0001346_abnormal_lacrimal_gland1.47812631
61* MP0000716_abnormal_immune_system1.45317128
62MP0005166_decreased_susceptibility_to1.44088307
63MP0003646_muscle_fatigue1.43196449
64MP0003329_amyloid_beta_deposits1.41559504
65MP0003828_pulmonary_edema1.39155337
66MP0004145_abnormal_muscle_electrophysio1.38841091
67MP0003448_altered_tumor_morphology1.37690972
68MP0001529_abnormal_vocalization1.37580294
69MP0005167_abnormal_blood-brain_barrier1.36877645
70MP0003634_abnormal_glial_cell1.36677026
71MP0003195_calcinosis1.36613008
72MP0004147_increased_porphyrin_level1.35376700
73MP0002398_abnormal_bone_marrow1.34969633
74MP0003868_abnormal_feces_composition1.34555415
75MP0003693_abnormal_embryo_hatching1.34491286
76MP0002998_abnormal_bone_remodeling1.33328389
77MP0003632_abnormal_nervous_system1.31407901
78MP0000343_altered_response_to1.30414031
79MP0001661_extended_life_span1.30300523
80MP0005551_abnormal_eye_electrophysiolog1.26394099
81MP0003183_abnormal_peptide_metabolism1.25894963
82MP0003763_abnormal_thymus_physiology1.22573856
83MP0000858_altered_metastatic_potential1.22233836
84MP0005464_abnormal_platelet_physiology1.20206550
85MP0000579_abnormal_nail_morphology1.20081285
86MP0003699_abnormal_female_reproductive1.20022634
87MP0001730_embryonic_growth_arrest1.20013778
88MP0005164_abnormal_response_to1.19976737
89MP0004264_abnormal_extraembryonic_tissu1.18285210
90MP0000747_muscle_weakness1.16689949
91* MP0002429_abnormal_blood_cell1.13392293
92MP0003111_abnormal_nucleus_morphology1.10479560
93MP0005395_other_phenotype1.10450749
94MP0000689_abnormal_spleen_morphology1.07622611
95MP0005408_hypopigmentation1.07421776
96MP0005623_abnormal_meninges_morphology1.06723397
97MP0002006_tumorigenesis1.06580584
98MP0004883_abnormal_blood_vessel1.06011582
99MP0004808_abnormal_hematopoietic_stem1.04757232
100MP0004043_abnormal_pH_regulation1.04555148
101MP0002139_abnormal_hepatobiliary_system1.04198474
102MP0000003_abnormal_adipose_tissue1.04174821
103MP0001485_abnormal_pinna_reflex1.02237699
104MP0003091_abnormal_cell_migration1.01806977
105MP0009046_muscle_twitch1.01681466
106MP0002722_abnormal_immune_system1.01287591
107MP0005666_abnormal_adipose_tissue1.00034921
108MP0005375_adipose_tissue_phenotype0.96575112
109MP0010352_gastrointestinal_tract_polyps0.95730457
110MP0005365_abnormal_bile_salt0.93680173
111MP0000569_abnormal_digit_pigmentation0.93511617
112MP0005076_abnormal_cell_differentiation0.93178453
113MP0004742_abnormal_vestibular_system0.92847030
114MP0001905_abnormal_dopamine_level0.92797071
115MP0000462_abnormal_digestive_system0.92148004
116MP0003221_abnormal_cardiomyocyte_apopto0.91671826
117MP0005058_abnormal_lysosome_morphology0.91506497
118MP0002269_muscular_atrophy0.90917394
119MP0004510_myositis0.90651190
120MP0002254_reproductive_system_inflammat0.89019173
121MP0001663_abnormal_digestive_system0.88457262
122MP0003690_abnormal_glial_cell0.87653086
123MP0002277_abnormal_respiratory_mucosa0.86691647
124MP0002163_abnormal_gland_morphology0.86284567
125MP0005379_endocrine/exocrine_gland_phen0.84908775
126MP0004957_abnormal_blastocyst_morpholog0.83121579
127MP0003045_fibrosis0.82455640
128MP0003453_abnormal_keratinocyte_physiol0.81275894
129MP0001348_abnormal_lacrimal_gland0.81183909
130MP0001299_abnormal_eye_distance/0.79860898
131MP0002837_dystrophic_cardiac_calcinosis0.78714269
132MP0000604_amyloidosis0.77704685
133* MP0009763_increased_sensitivity_to0.77494752
134MP0003077_abnormal_cell_cycle0.77045372
135MP0002166_altered_tumor_susceptibility0.76995053
136MP0005621_abnormal_cell_physiology0.76583148
137MP0001727_abnormal_embryo_implantation0.76495822
138MP0001697_abnormal_embryo_size0.76072977
139MP0001765_abnormal_ion_homeostasis0.75630210
140* MP0009765_abnormal_xenobiotic_induced0.74986912
141MP0004381_abnormal_hair_follicle0.74307075
142MP0006082_CNS_inflammation0.73088721
143MP0005390_skeleton_phenotype0.71521876
144MP0002132_abnormal_respiratory_system0.71309658
145MP0004036_abnormal_muscle_relaxation0.71141703
146MP0004885_abnormal_endolymph0.70240676
147MP0002084_abnormal_developmental_patter0.68659688
148MP0002118_abnormal_lipid_homeostasis0.67988235
149MP0000465_gastrointestinal_hemorrhage0.67584761
150MP0010678_abnormal_skin_adnexa0.66932335
151MP0005195_abnormal_posterior_eye0.65710446
152MP0000703_abnormal_thymus_morphology0.65574485
153MP0002971_abnormal_brown_adipose0.65494257
154MP0000350_abnormal_cell_proliferation0.65293966
155MP0000249_abnormal_blood_vessel0.63792436
156MP0003880_abnormal_central_pattern0.63191078
157MP0001216_abnormal_epidermal_layer0.63052478
158MP0008995_early_reproductive_senescence0.62897584
159MP0000647_abnormal_sebaceous_gland0.62065740
160MP0003806_abnormal_nucleotide_metabolis0.62052964
161MP0001672_abnormal_embryogenesis/_devel0.60953429
162MP0005380_embryogenesis_phenotype0.60953429
163MP0000371_diluted_coat_color0.60840376
164MP0010094_abnormal_chromosome_stability0.60820917
165MP0002085_abnormal_embryonic_tissue0.59508132
166MP0009703_decreased_birth_body0.59428388
167MP0005023_abnormal_wound_healing0.59211877
168MP0003795_abnormal_bone_structure0.58512340
169MP0008874_decreased_physiological_sensi0.58173328
170MP0003984_embryonic_growth_retardation0.56959100
171MP0009672_abnormal_birth_weight0.56469393
172MP0009333_abnormal_splenocyte_physiolog0.56120889
173MP0000639_abnormal_adrenal_gland0.55745399
174MP0003631_nervous_system_phenotype0.55485819
175MP0003866_abnormal_defecation0.55287795
176MP0002092_abnormal_eye_morphology0.55014987
177MP0003303_peritoneal_inflammation0.54921603
178MP0000015_abnormal_ear_pigmentation0.54378836
179MP0002693_abnormal_pancreas_physiology0.53413242

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.96797673
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.37381693
3Absent/shortened dynein arms (HP:0200106)6.37381693
4Abnormal respiratory motile cilium physiology (HP:0012261)6.00815428
5Stomatitis (HP:0010280)5.55518937
6Recurrent bacterial skin infections (HP:0005406)5.44984504
7Male infertility (HP:0003251)5.40450958
8Abnormality of macrophages (HP:0004311)5.36930570
9Retrobulbar optic neuritis (HP:0100654)5.32526442
10Optic neuritis (HP:0100653)5.32526442
11Chronic bronchitis (HP:0004469)5.24950946
12Eczematoid dermatitis (HP:0000976)5.21540129
13Orchitis (HP:0100796)5.20860186
14Rhinitis (HP:0012384)4.98376847
15Recurrent abscess formation (HP:0002722)4.86247803
16Myositis (HP:0100614)4.78948547
17Abnormal respiratory epithelium morphology (HP:0012253)4.74769051
18Abnormal respiratory motile cilium morphology (HP:0005938)4.74769051
19Abnormal ciliary motility (HP:0012262)4.55999465
20Infertility (HP:0000789)4.47557693
21Mediastinal lymphadenopathy (HP:0100721)4.37132725
22Sensory axonal neuropathy (HP:0003390)4.32948324
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.20717338
24Degeneration of the lateral corticospinal tracts (HP:0002314)4.20717338
25Elevated erythrocyte sedimentation rate (HP:0003565)3.97791601
26Peripheral hypomyelination (HP:0007182)3.96426966
27Recurrent gram-negative bacterial infections (HP:0005420)3.79832991
28Keratoconjunctivitis sicca (HP:0001097)3.78884248
29Slow saccadic eye movements (HP:0000514)3.77528155
30Keratoconjunctivitis (HP:0001096)3.38409243
31Recurrent fungal infections (HP:0002841)3.31918767
32Increased cerebral lipofuscin (HP:0011813)3.30639100
33Loss of speech (HP:0002371)3.30494474
34Urticaria (HP:0001025)3.24093046
35Increased IgE level (HP:0003212)3.23907424
36Nasal polyposis (HP:0100582)3.22706305
37Vacuolated lymphocytes (HP:0001922)3.22219101
38Bronchiectasis (HP:0002110)3.19524756
39Recurrent skin infections (HP:0001581)3.17524312
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.14253435
41Vasculitis (HP:0002633)3.11853855
42Abnormality of the corticospinal tract (HP:0002492)3.10207620
43Abnormal gallbladder physiology (HP:0012438)3.09250958
44Cholecystitis (HP:0001082)3.09250958
45Autoimmune thrombocytopenia (HP:0001973)3.04960745
46Pulmonary infiltrates (HP:0002113)3.03819919
47Gastrointestinal infarctions (HP:0005244)3.03758509
48Fatigue (HP:0012378)3.03502142
49Neurofibrillary tangles (HP:0002185)2.98006032
50Disinhibition (HP:0000734)2.95483312
51Hemoptysis (HP:0002105)2.95367499
52Gingivitis (HP:0000230)2.94340926
53Dysostosis multiplex (HP:0000943)2.92366459
54Gangrene (HP:0100758)2.89456955
55Abnormal spermatogenesis (HP:0008669)2.84939803
56Bronchitis (HP:0012387)2.78690810
57Mutism (HP:0002300)2.67712872
58Recurrent viral infections (HP:0004429)2.67376587
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.66819319
60Azoospermia (HP:0000027)2.63942726
61Episodic fever (HP:0001954)2.59387473
62Abnormality of midbrain morphology (HP:0002418)2.59134655
63Molar tooth sign on MRI (HP:0002419)2.59134655
64Meningitis (HP:0001287)2.59061261
65Spastic tetraparesis (HP:0001285)2.57471403
66Leukocytosis (HP:0001974)2.55550906
67Polyneuropathy (HP:0001271)2.54945398
68Amyloidosis (HP:0011034)2.53865892
69Dyschromatopsia (HP:0007641)2.51728029
70Dysmetria (HP:0001310)2.51165708
71Encephalitis (HP:0002383)2.49409091
72Acanthocytosis (HP:0001927)2.49171193
73Malnutrition (HP:0004395)2.44077045
74Increased serum ferritin (HP:0003281)2.43125831
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42728561
76Abnormality of polysaccharide metabolism (HP:0011012)2.42728561
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42728561
78Obstructive lung disease (HP:0006536)2.42265553
79Chronic obstructive pulmonary disease (HP:0006510)2.42265553
80Anorexia (HP:0002039)2.41274769
81Arterial thrombosis (HP:0004420)2.40773207
82Spastic gait (HP:0002064)2.39885909
83Adrenal hypoplasia (HP:0000835)2.39461658
84Spontaneous hematomas (HP:0007420)2.38407305
85Papillary thyroid carcinoma (HP:0002895)2.38250334
86Recurrent cutaneous fungal infections (HP:0011370)2.37436402
87Chronic mucocutaneous candidiasis (HP:0002728)2.37436402
88Genetic anticipation (HP:0003743)2.37402230
89Abnormality of saccadic eye movements (HP:0000570)2.36286824
90Hematochezia (HP:0002573)2.36203869
91Heterotopia (HP:0002282)2.33285158
92T lymphocytopenia (HP:0005403)2.32463487
93Abnormal delayed hypersensitivity skin test (HP:0002963)2.32081272
94Abnormality of macular pigmentation (HP:0008002)2.31260698
95Recurrent otitis media (HP:0000403)2.30875655
96Abnormality of T cell number (HP:0011839)2.30025488
97Mucopolysacchariduria (HP:0008155)2.25183260
98Urinary glycosaminoglycan excretion (HP:0003541)2.25183260
99Impulsivity (HP:0100710)2.24345764
100Increased IgM level (HP:0003496)2.23724720
101Nephronophthisis (HP:0000090)2.22401961
102Abnormality of the endocardium (HP:0004306)2.22183497
103Onion bulb formation (HP:0003383)2.19933105
104Abnormality of the nasal mucosa (HP:0000433)2.16524573
105Hypergammaglobulinemia (HP:0010702)2.13667521
106Spontaneous abortion (HP:0005268)2.12590172
107Amaurosis fugax (HP:0100576)2.11900564
108Termporal pattern (HP:0011008)2.11724023
109Insidious onset (HP:0003587)2.11724023
110Neuronal loss in central nervous system (HP:0002529)2.10887788
111Pustule (HP:0200039)2.09413992
112Congenital ichthyosiform erythroderma (HP:0007431)2.09101766
113Abnormality of the pleura (HP:0002103)2.06282871
114Systemic lupus erythematosus (HP:0002725)2.05899890
115Autoimmune hemolytic anemia (HP:0001890)2.05822168
116Cerebral inclusion bodies (HP:0100314)2.05571304
117Abnormality of lateral ventricle (HP:0030047)2.01699890
118Abnormal auditory evoked potentials (HP:0006958)2.01458487
119Hyporeflexia of lower limbs (HP:0002600)2.01191352
120Parakeratosis (HP:0001036)2.01063678
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00969477
122Muscle fiber splitting (HP:0003555)1.99583747
123Chest pain (HP:0100749)1.98864720
124Akinesia (HP:0002304)1.98769919
125Medial flaring of the eyebrow (HP:0010747)1.98163875
126Myocardial infarction (HP:0001658)1.97977791
127Keratitis (HP:0000491)1.96702682
128Abnormality of iron homeostasis (HP:0011031)1.94935963
129Anteriorly placed anus (HP:0001545)1.94861180
130Vertigo (HP:0002321)1.94805797
131Cerebral hypomyelination (HP:0006808)1.94582617
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93474658
133Hyperkalemia (HP:0002153)1.93364670
134Decreased central vision (HP:0007663)1.92993402
135Poikilocytosis (HP:0004447)1.92872601
136Recurrent bronchitis (HP:0002837)1.91928523
137Chronic otitis media (HP:0000389)1.90968641
138Cone-rod dystrophy (HP:0000548)1.88171156
139Apathy (HP:0000741)1.88157777
140Interstitial pulmonary disease (HP:0006530)1.87657598
141Osteomyelitis (HP:0002754)1.87626270
142Intention tremor (HP:0002080)1.86927318
143Urinary bladder sphincter dysfunction (HP:0002839)1.86686250
144Arthralgia (HP:0002829)1.86647023
145Eosinophilia (HP:0001880)1.86406347
146Bony spicule pigmentary retinopathy (HP:0007737)1.85829351
147Joint swelling (HP:0001386)1.85182609
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83935507
149Abnormality of the pericardium (HP:0001697)1.83381857
150Agnosia (HP:0010524)1.82806802
151Abnormality of the peritoneum (HP:0002585)1.81917438
152Spastic paraparesis (HP:0002313)1.81695309
153Diminished motivation (HP:0000745)1.81373696
154Basal ganglia calcification (HP:0002135)1.80956801
155Granulocytopenia (HP:0001913)1.79580957
156Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79017652
157Inappropriate behavior (HP:0000719)1.78981617
158Gowers sign (HP:0003391)1.78594924
159Gingival bleeding (HP:0000225)1.78360770
160Generalized myoclonic seizures (HP:0002123)1.76940365
161Insulin-resistant diabetes mellitus (HP:0000831)1.76259480
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75295956
163Birth length less than 3rd percentile (HP:0003561)1.74495376
164Recurrent sinusitis (HP:0011108)1.73777524
165Secondary amenorrhea (HP:0000869)1.72496730
166Decreased motor nerve conduction velocity (HP:0003431)1.70990669
167Gaze-evoked nystagmus (HP:0000640)1.69927029
168Thickened helices (HP:0000391)1.69876536
169Poor coordination (HP:0002370)1.69693557
170Supranuclear gaze palsy (HP:0000605)1.64939737
171Abnormality of glycolipid metabolism (HP:0010969)1.64291525
172Abnormality of liposaccharide metabolism (HP:0010968)1.64291525
173Abnormality of glycosphingolipid metabolism (HP:0004343)1.64291525
174Scanning speech (HP:0002168)1.60889244
175Ectopic kidney (HP:0000086)1.59726788
176Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58308707
177Oculomotor apraxia (HP:0000657)1.57302128
178Progressive neurologic deterioration (HP:0002344)1.57195729
179Morphological abnormality of the pyramidal tract (HP:0002062)1.56565589
180Villous atrophy (HP:0011473)1.55356482
181Abnormality of small intestinal villus morphology (HP:0011472)1.55356482
182Ileus (HP:0002595)1.55317353
183Clonus (HP:0002169)1.55050174
184Depressed nasal tip (HP:0000437)1.55036901
185Intrahepatic cholestasis (HP:0001406)1.52811599
186Dysmetric saccades (HP:0000641)1.50854543
187Polycythemia (HP:0001901)1.50589435
188Aplasia/Hypoplasia involving the musculature (HP:0001460)1.50227119
189Ureteral duplication (HP:0000073)1.47386330
190Facial hemangioma (HP:0000329)1.47025537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.44667551
2IRAK34.35971798
3RIPK43.49062088
4LATS13.36981102
5EPHB13.22798699
6PRKD33.05577067
7MAP3K142.99446328
8IRAK42.93506048
9ICK2.77130248
10PDK32.54964971
11PDK42.54964971
12BLK2.51656891
13TYK22.37043329
14TAOK12.33558657
15TAOK32.33057682
16IKBKE2.27701826
17CDK122.26335492
18MAP3K32.21025390
19OXSR12.17344933
20IKBKB2.15933204
21MATK2.13742379
22MAP2K32.09280433
23PRPF4B2.02087132
24WNK42.00538603
25MAP3K61.99277142
26TBK11.97458829
27WNK11.96726432
28SIK31.95192061
29PLK41.95090927
30GRK71.85266187
31PBK1.78663496
32STK31.75487197
33TAOK21.71994238
34BRAF1.68626337
35PNCK1.66592975
36JAK31.65626350
37MAPK151.60833640
38ZAP701.59349077
39CHUK1.51305530
40MUSK1.50029043
41ERN11.48347361
42PKN11.42520146
43DDR21.41598701
44MAP3K111.41136489
45TYRO31.39190000
46PDK21.38951734
47MET1.37112912
48NEK21.35714553
49JAK11.34193694
50LATS21.30975297
51TESK21.30937815
52DMPK1.30924639
53MAP3K51.27240161
54STK38L1.25205488
55TESK11.24315050
56MAP3K131.22924913
57CDC71.19090033
58IRAK21.18869911
59MAP3K11.18292046
60PIK3CG1.15897526
61ERBB41.14456498
62PAK61.13684943
63TXK1.11810789
64NEK61.11207394
65CDC42BPA1.10646220
66STK101.09620316
67CHEK21.06101337
68MELK1.05502018
69TTK1.04162855
70JAK21.03706297
71BRSK21.02880269
72MOS1.02841975
73PRKD20.98786490
74SYK0.98493383
75MAPKAPK50.97924080
76CSF1R0.97044481
77NLK0.96949235
78LYN0.96643284
79HCK0.95652988
80CSNK1G10.95225601
81HIPK20.94565951
82PDK10.93197734
83CSNK1A1L0.92109670
84TNIK0.91613168
85PDPK10.91058023
86AKT30.90746112
87STK240.89719332
88TNK20.89019600
89CAMK1D0.88183584
90ABL20.87234567
91MARK20.82887190
92CSNK1G20.81869848
93SIK20.78925927
94MAP3K90.78257997
95CSNK1G30.77628858
96ACVR1B0.76709777
97BTK0.76400853
98STK380.75864251
99PRKCQ0.75822116
100TGFBR20.75392919
101LCK0.74359918
102ADRBK20.73332163
103MAP3K20.71366677
104PTK2B0.70713699
105PIM10.69532505
106SGK30.68527068
107EPHA30.67938819
108CHEK10.66389075
109LIMK10.65843298
110KSR20.65750553
111RIPK10.64909731
112KIT0.64157260
113PIM20.63678552
114MAP2K20.63095935
115PRKAA10.62884088
116BRD40.62718755
117CLK10.62313185
118MAPK100.61502164
119FES0.61214622
120STK110.60039869
121CAMK1G0.59938007
122ARAF0.59338660
123PRKAA20.58385704
124TRPM70.57939638
125CSNK1D0.57127836
126ITK0.57066702
127NUAK10.55858906
128KSR10.55247813
129SGK20.54412662
130NEK90.53958293
131SIK10.53099730
132MTOR0.53038724
133CDK90.52686706
134PDGFRB0.51181633
135ALK0.50801559
136BMPR20.48648369
137ROCK20.47783739
138SRPK10.47475754
139YES10.46529634
140ABL10.46036462
141STK40.46027789
142FGR0.45434695
143DYRK30.45203199
144GRK60.44715784
145CAMK2B0.44635940
146MST40.44445818
147TLK10.43955736
148SGK2230.43909562
149SGK4940.43909562
150TEC0.43303907
151CSK0.42533247
152RPS6KA10.42398248
153ATM0.42098834
154NME20.41971752
155CDK30.41727131
156PAK30.41025312
157CAMK2D0.39841922
158NTRK10.39214858
159RPS6KL10.38451341
160RPS6KC10.38451341
161MAP4K10.38280715
162CDK60.37633531
163IRAK10.36964472
164PAK10.36196045
165MARK30.35034361
166PRKD10.34616714
167PRKCH0.34406583
168RPS6KA60.33654335

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.52870149
2Basal transcription factors_Homo sapiens_hsa030223.39658816
3Allograft rejection_Homo sapiens_hsa053303.15939201
4Asthma_Homo sapiens_hsa053102.95692206
5Leishmaniasis_Homo sapiens_hsa051402.85047829
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.82026951
7Dorso-ventral axis formation_Homo sapiens_hsa043202.80674843
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.79795146
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.73325244
10Ether lipid metabolism_Homo sapiens_hsa005652.65497027
11Autoimmune thyroid disease_Homo sapiens_hsa053202.63214844
12Osteoclast differentiation_Homo sapiens_hsa043802.62219803
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60199440
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.55299112
15Linoleic acid metabolism_Homo sapiens_hsa005912.49635358
16Steroid biosynthesis_Homo sapiens_hsa001002.43823936
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41366972
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.34376572
19NF-kappa B signaling pathway_Homo sapiens_hsa040642.31481320
20Legionellosis_Homo sapiens_hsa051342.25225046
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22958015
22Glycerophospholipid metabolism_Homo sapiens_hsa005642.07140935
23TNF signaling pathway_Homo sapiens_hsa046682.06853693
24Graft-versus-host disease_Homo sapiens_hsa053322.02674944
25Tuberculosis_Homo sapiens_hsa051522.00880913
26Staphylococcus aureus infection_Homo sapiens_hsa051502.00845133
27Malaria_Homo sapiens_hsa051441.98216872
28Renal cell carcinoma_Homo sapiens_hsa052111.92892086
29Sphingolipid metabolism_Homo sapiens_hsa006001.90373494
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87367826
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83630314
32Rheumatoid arthritis_Homo sapiens_hsa053231.81884390
33Measles_Homo sapiens_hsa051621.81713442
34Influenza A_Homo sapiens_hsa051641.79969879
35Hematopoietic cell lineage_Homo sapiens_hsa046401.78316156
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67930223
37Type I diabetes mellitus_Homo sapiens_hsa049401.60410456
38African trypanosomiasis_Homo sapiens_hsa051431.58942334
39Fatty acid elongation_Homo sapiens_hsa000621.58887773
40Pertussis_Homo sapiens_hsa051331.55063162
41Toxoplasmosis_Homo sapiens_hsa051451.52993650
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45640956
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45107604
44Sulfur metabolism_Homo sapiens_hsa009201.41342299
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38706555
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38546546
47Salmonella infection_Homo sapiens_hsa051321.36558179
48RNA degradation_Homo sapiens_hsa030181.31603284
49Acute myeloid leukemia_Homo sapiens_hsa052211.29533330
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26629760
51Phototransduction_Homo sapiens_hsa047441.26553318
52Hepatitis C_Homo sapiens_hsa051601.26150891
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25598986
54Histidine metabolism_Homo sapiens_hsa003401.24483562
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22654885
56Hepatitis B_Homo sapiens_hsa051611.22393971
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18363836
58Endocytosis_Homo sapiens_hsa041441.17056638
59ABC transporters_Homo sapiens_hsa020101.15459490
60Inositol phosphate metabolism_Homo sapiens_hsa005621.14738381
61Regulation of autophagy_Homo sapiens_hsa041401.12579479
62Pentose phosphate pathway_Homo sapiens_hsa000301.11605858
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08938052
64Ovarian steroidogenesis_Homo sapiens_hsa049131.08125015
65Phagosome_Homo sapiens_hsa041451.07562700
66Glycosaminoglycan degradation_Homo sapiens_hsa005311.05914037
67Antigen processing and presentation_Homo sapiens_hsa046121.02826001
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02611976
69Viral myocarditis_Homo sapiens_hsa054161.01018248
70Shigellosis_Homo sapiens_hsa051310.99066693
71Oocyte meiosis_Homo sapiens_hsa041140.96667028
72Apoptosis_Homo sapiens_hsa042100.95344486
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94928826
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92898724
75Cell cycle_Homo sapiens_hsa041100.89629474
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89138379
77Pancreatic cancer_Homo sapiens_hsa052120.88853691
78Lysine degradation_Homo sapiens_hsa003100.88200800
79Protein export_Homo sapiens_hsa030600.87871947
80Glycerolipid metabolism_Homo sapiens_hsa005610.86830991
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.83522130
82RNA transport_Homo sapiens_hsa030130.83447858
83Fanconi anemia pathway_Homo sapiens_hsa034600.82845436
84Amoebiasis_Homo sapiens_hsa051460.82369945
85Circadian rhythm_Homo sapiens_hsa047100.81185244
86Primary immunodeficiency_Homo sapiens_hsa053400.79828134
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79124500
88Epstein-Barr virus infection_Homo sapiens_hsa051690.78701009
89Choline metabolism in cancer_Homo sapiens_hsa052310.77495762
90Type II diabetes mellitus_Homo sapiens_hsa049300.73335863
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71879026
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.71756881
93Lysosome_Homo sapiens_hsa041420.69509314
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69406139
95Bladder cancer_Homo sapiens_hsa052190.68399657
96ErbB signaling pathway_Homo sapiens_hsa040120.68262386
97Prostate cancer_Homo sapiens_hsa052150.67775979
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67122698
99Nitrogen metabolism_Homo sapiens_hsa009100.67002646
100Folate biosynthesis_Homo sapiens_hsa007900.66776941
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.65661179
102VEGF signaling pathway_Homo sapiens_hsa043700.65402934
103Chronic myeloid leukemia_Homo sapiens_hsa052200.65274609
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62949487
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.61652951
106Fructose and mannose metabolism_Homo sapiens_hsa000510.61590183
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.61197711
108Tight junction_Homo sapiens_hsa045300.59704940
109Fatty acid biosynthesis_Homo sapiens_hsa000610.59000494
110MAPK signaling pathway_Homo sapiens_hsa040100.56471461
111Prolactin signaling pathway_Homo sapiens_hsa049170.55566962
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55199469
113Arginine and proline metabolism_Homo sapiens_hsa003300.55165749
114p53 signaling pathway_Homo sapiens_hsa041150.54906981
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54102288
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.53779127
117B cell receptor signaling pathway_Homo sapiens_hsa046620.52557377
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52062554
119Homologous recombination_Homo sapiens_hsa034400.51957803
120Viral carcinogenesis_Homo sapiens_hsa052030.50918818
121mTOR signaling pathway_Homo sapiens_hsa041500.49780882
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.49416627
123Arachidonic acid metabolism_Homo sapiens_hsa005900.49318420
124Insulin resistance_Homo sapiens_hsa049310.48811193
125T cell receptor signaling pathway_Homo sapiens_hsa046600.48389540
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46835177
127Non-homologous end-joining_Homo sapiens_hsa034500.46436831
128RNA polymerase_Homo sapiens_hsa030200.45684309
129mRNA surveillance pathway_Homo sapiens_hsa030150.44899214
130HIF-1 signaling pathway_Homo sapiens_hsa040660.44746066
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44615445
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.44468055
133Prion diseases_Homo sapiens_hsa050200.44408964
134Platelet activation_Homo sapiens_hsa046110.44306835
135Ras signaling pathway_Homo sapiens_hsa040140.43681016
136Selenocompound metabolism_Homo sapiens_hsa004500.42980005
137Other glycan degradation_Homo sapiens_hsa005110.42422310
138Collecting duct acid secretion_Homo sapiens_hsa049660.42285229
139Glutathione metabolism_Homo sapiens_hsa004800.41522259
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40185694
141Endometrial cancer_Homo sapiens_hsa052130.38540845
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38143096
143HTLV-I infection_Homo sapiens_hsa051660.36143519
144Chemokine signaling pathway_Homo sapiens_hsa040620.35226136
145Herpes simplex infection_Homo sapiens_hsa051680.35046642
146FoxO signaling pathway_Homo sapiens_hsa040680.33906615
147Notch signaling pathway_Homo sapiens_hsa043300.33800418
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33648534
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33536321
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32392124
151MicroRNAs in cancer_Homo sapiens_hsa052060.32343373
152Mineral absorption_Homo sapiens_hsa049780.31907354
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31833189
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31626064
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31112367
156GnRH signaling pathway_Homo sapiens_hsa049120.30864193
157AMPK signaling pathway_Homo sapiens_hsa041520.30790789
158Non-small cell lung cancer_Homo sapiens_hsa052230.28746328
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27799551
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27050735
161Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25797681
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24857394
163Glucagon signaling pathway_Homo sapiens_hsa049220.24701537
164Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24626823
165Olfactory transduction_Homo sapiens_hsa047400.24028246
166Small cell lung cancer_Homo sapiens_hsa052220.21996123

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