MTDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)4.73823672
2COPI coating of Golgi vesicle (GO:0048205)4.18137114
3Golgi transport vesicle coating (GO:0048200)4.18137114
4regulation of translational fidelity (GO:0006450)4.13716565
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.08221431
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08221431
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.08221431
8modulation by symbiont of host immune response (GO:0052553)4.08221431
9positive regulation by symbiont of host defense response (GO:0052509)4.08221431
10modulation by symbiont of host defense response (GO:0052031)4.08221431
11nuclear pore complex assembly (GO:0051292)3.89938902
12formation of translation preinitiation complex (GO:0001731)3.66906889
13nucleobase-containing small molecule interconversion (GO:0015949)3.66246467
14folic acid metabolic process (GO:0046655)3.55838537
15ribosome assembly (GO:0042255)3.55166602
16negative regulation of B cell proliferation (GO:0030889)3.48061301
17mitotic sister chromatid cohesion (GO:0007064)3.42233354
18folic acid-containing compound biosynthetic process (GO:0009396)3.29051164
19axon ensheathment in central nervous system (GO:0032291)3.24613541
20central nervous system myelination (GO:0022010)3.24613541
21regulation of translational termination (GO:0006449)3.24139146
22regulation of DNA endoreduplication (GO:0032875)3.22757249
23hemidesmosome assembly (GO:0031581)3.22104431
24ER overload response (GO:0006983)3.14018752
25nuclear pore organization (GO:0006999)3.13811104
26regulation of glucose import in response to insulin stimulus (GO:2001273)3.13352730
27microglial cell activation (GO:0001774)3.12974041
28pore complex assembly (GO:0046931)3.11767942
29glucocorticoid receptor signaling pathway (GO:0042921)3.11626270
30DNA duplex unwinding (GO:0032508)3.07725375
31DNA strand elongation involved in DNA replication (GO:0006271)3.04751928
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03797361
33COPII vesicle coating (GO:0048208)3.03409872
34negative regulation of DNA repair (GO:0045738)3.00914299
35B cell homeostasis (GO:0001782)2.98913484
36DNA strand elongation (GO:0022616)2.98463958
37pinocytosis (GO:0006907)2.96051706
38activated T cell proliferation (GO:0050798)2.95806487
39alternative mRNA splicing, via spliceosome (GO:0000380)2.95461957
40mitotic nuclear envelope disassembly (GO:0007077)2.94999004
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94932142
42mammary gland epithelial cell proliferation (GO:0033598)2.94624933
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92327505
44DNA topological change (GO:0006265)2.90168122
45DNA geometric change (GO:0032392)2.89472467
46neutrophil activation involved in immune response (GO:0002283)2.87024776
47sister chromatid segregation (GO:0000819)2.86882856
48protein localization to chromosome, centromeric region (GO:0071459)2.86686339
49protein localization to endosome (GO:0036010)2.83507694
50corticosteroid receptor signaling pathway (GO:0031958)2.83252403
51dosage compensation (GO:0007549)2.79300369
52telomere maintenance via semi-conservative replication (GO:0032201)2.76542952
53membrane disassembly (GO:0030397)2.76281059
54nuclear envelope disassembly (GO:0051081)2.76281059
55DNA unwinding involved in DNA replication (GO:0006268)2.75742866
56mitotic sister chromatid segregation (GO:0000070)2.75627171
57ribosomal small subunit biogenesis (GO:0042274)2.74437852
58Rap protein signal transduction (GO:0032486)2.73208564
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72075115
60telomere maintenance via recombination (GO:0000722)2.71590249
61mitotic recombination (GO:0006312)2.71164225
62ribosome biogenesis (GO:0042254)2.69780949
63DNA conformation change (GO:0071103)2.69146165
64protein export from nucleus (GO:0006611)2.68496546
65deoxyribonucleotide biosynthetic process (GO:0009263)2.66976344
66positive regulation of interleukin-17 production (GO:0032740)2.66684713
67ribonucleoprotein complex biogenesis (GO:0022613)2.66671185
68viral transcription (GO:0019083)2.66333016
69translational termination (GO:0006415)2.65484396
70kinetochore organization (GO:0051383)2.63897785
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63655640
72activation of Rac GTPase activity (GO:0032863)2.62773546
73regulation of sister chromatid cohesion (GO:0007063)2.62709631
74regulation of RNA export from nucleus (GO:0046831)2.62156031
75endoplasmic reticulum unfolded protein response (GO:0030968)2.61203757
76DNA replication initiation (GO:0006270)2.60745448
77hepatocyte apoptotic process (GO:0097284)2.60648650
78ER-nucleus signaling pathway (GO:0006984)2.59486218
79positive regulation of protein import into nucleus, translocation (GO:0033160)2.59276143
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.58860362
81regulation of translational elongation (GO:0006448)2.57935350
82protein N-linked glycosylation via asparagine (GO:0018279)2.57565880
83positive regulation of nuclease activity (GO:0032075)2.57249245
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56199094
85positive regulation of toll-like receptor signaling pathway (GO:0034123)2.55966137
86protein maturation by protein folding (GO:0022417)2.55669974
87positive regulation of mitotic sister chromatid separation (GO:1901970)2.54782032
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54782032
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54782032
90peptidyl-asparagine modification (GO:0018196)2.54341879
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53360503
92macrophage activation involved in immune response (GO:0002281)2.52479672
93response to muramyl dipeptide (GO:0032495)2.52403737
94chromosome condensation (GO:0030261)2.51340775
95histone H3-K4 trimethylation (GO:0080182)2.49163073
96B cell receptor signaling pathway (GO:0050853)2.48480887
97hypotonic response (GO:0006971)2.47426816
98ensheathment of neurons (GO:0007272)2.46109044
99axon ensheathment (GO:0008366)2.46109044
100protein retention in ER lumen (GO:0006621)2.45546062
101myelination (GO:0042552)2.45035736
102positive regulation of keratinocyte differentiation (GO:0045618)2.44459353
103respiratory burst (GO:0045730)2.44272276
104protein N-linked glycosylation (GO:0006487)2.43933153
105regulation of interferon-beta biosynthetic process (GO:0045357)2.43826694
106regulation of histone H3-K9 methylation (GO:0051570)2.43120545
107embryonic process involved in female pregnancy (GO:0060136)2.42554599
108regulation of protein export from nucleus (GO:0046825)2.41769988
109folic acid-containing compound metabolic process (GO:0006760)2.41605022
110cellular response to unfolded protein (GO:0034620)2.41030202
111vesicle coating (GO:0006901)2.40303259
112positive regulation of histone H3-K4 methylation (GO:0051571)2.39170699
113establishment of integrated proviral latency (GO:0075713)2.38665383
114regulation of nuclease activity (GO:0032069)2.38660139
115cytoplasmic mRNA processing body assembly (GO:0033962)2.38551626
116regulation of centriole replication (GO:0046599)2.37491828
117cell-substrate junction assembly (GO:0007044)2.36599081
118cell adhesion mediated by integrin (GO:0033627)2.36018162
119skin morphogenesis (GO:0043589)2.35530023
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.35295768
121regulation of histone H3-K27 methylation (GO:0061085)2.34565301
122DNA synthesis involved in DNA repair (GO:0000731)2.33780564
123DNA packaging (GO:0006323)2.33361932
124myeloid cell homeostasis (GO:0002262)2.33175276
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32347238
126response to host immune response (GO:0052572)2.32347238
127establishment of chromosome localization (GO:0051303)2.31007835
128negative regulation of mRNA metabolic process (GO:1903312)2.30724799
129negative regulation of neurotransmitter secretion (GO:0046929)2.30624955
130positive regulation of interferon-alpha production (GO:0032727)2.29892543
131nuclear envelope organization (GO:0006998)2.29768439
132mitotic metaphase plate congression (GO:0007080)2.29356769
133tetrahydrofolate metabolic process (GO:0046653)2.29186946
134regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.27586582
135positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.27586582
136neutrophil activation (GO:0042119)2.26770218
137germinal center formation (GO:0002467)2.26227141
138response to peptidoglycan (GO:0032494)2.24208775
139ribosomal large subunit biogenesis (GO:0042273)2.23597129
140regulation of interferon-alpha production (GO:0032647)2.22879262
141RNA stabilization (GO:0043489)2.22827663
142lymphoid progenitor cell differentiation (GO:0002320)2.22782774
143cotranslational protein targeting to membrane (GO:0006613)2.22692216
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.22638111
145negative regulation of translation, ncRNA-mediated (GO:0040033)2.22638111
146regulation of translation, ncRNA-mediated (GO:0045974)2.22638111
147definitive hemopoiesis (GO:0060216)2.22547664
148positive regulation of gamma-delta T cell activation (GO:0046645)2.22189139
149nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.22044490
150mRNA splice site selection (GO:0006376)2.21816714
151response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.20470652
152response to host (GO:0075136)2.20470652
153response to host defenses (GO:0052200)2.20470652
154DNA ligation (GO:0006266)2.19960631
155positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.19216043
156protein targeting to ER (GO:0045047)2.19152845
157positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.19098439
158leukocyte aggregation (GO:0070486)2.18929123
159establishment of protein localization to endoplasmic reticulum (GO:0072599)2.18462691
160I-kappaB phosphorylation (GO:0007252)2.18445012
161regulation of interleukin-17 production (GO:0032660)2.17517855
162regulation of mRNA 3-end processing (GO:0031440)2.17438721
163myeloid cell activation involved in immune response (GO:0002275)2.16453277
164SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.16323836
165T cell homeostasis (GO:0043029)2.16264810
166mature B cell differentiation (GO:0002335)2.16232789
167positive regulation of B cell differentiation (GO:0045579)2.14453580
168regulation of helicase activity (GO:0051095)2.13836684
169establishment of mitotic spindle orientation (GO:0000132)2.12824752
170positive regulation of defense response to virus by host (GO:0002230)2.12334315
171positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.11821567
172regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.11821567
173positive regulation of chromosome segregation (GO:0051984)2.09802748
174maturation of SSU-rRNA (GO:0030490)2.09304707
175granulocyte activation (GO:0036230)2.08740240
176regulation of nucleobase-containing compound transport (GO:0032239)2.08440014
177leukocyte homeostasis (GO:0001776)2.08283676
178histone H2B ubiquitination (GO:0033523)2.07677255
179regulation of mitotic spindle organization (GO:0060236)2.07034590
180protein localization to kinetochore (GO:0034501)2.06610736
181lymphocyte homeostasis (GO:0002260)2.05956075
182regulation of histone H3-K4 methylation (GO:0051569)2.04906269
183positive regulation of interleukin-1 beta secretion (GO:0050718)2.04486281
184establishment of mitotic spindle localization (GO:0040001)2.03926864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.37762788
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.55437686
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.50327820
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.96020738
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.56883170
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00820453
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.99803938
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89597794
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.88313779
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.82758064
11MYC_22102868_ChIP-Seq_BL_Human2.79257700
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.56565917
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48476198
14SCL_19346495_ChIP-Seq_HPC-7_Human2.45404415
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.32255855
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.30438632
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27498427
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.22989112
19FUS_26573619_Chip-Seq_HEK293_Human2.09404870
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06347616
21* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.04051867
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03464095
23ZNF263_19887448_ChIP-Seq_K562_Human2.01041646
24EWS_26573619_Chip-Seq_HEK293_Human2.00061743
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.99577638
26ELK1_19687146_ChIP-ChIP_HELA_Human1.98184903
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92321623
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92247283
29* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91101133
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90831259
31* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87388317
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83920421
33DCP1A_22483619_ChIP-Seq_HELA_Human1.83109860
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81727848
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81130100
36GATA1_22025678_ChIP-Seq_K562_Human1.77529506
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76560124
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75952090
39TP53_16413492_ChIP-PET_HCT116_Human1.73063348
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71281185
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70453670
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.64240380
43TFEB_21752829_ChIP-Seq_HELA_Human1.62033403
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61521442
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59778401
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58260451
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56965436
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55608232
49KDM5A_27292631_Chip-Seq_BREAST_Human1.55315415
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53339404
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52959208
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52300350
53SPI1_23547873_ChIP-Seq_NB4_Human1.50741024
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50217070
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48663568
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48404118
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47104015
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46666902
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45999873
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44205161
61MYB_26560356_Chip-Seq_TH2_Human1.43226945
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43154064
63AR_21909140_ChIP-Seq_LNCAP_Human1.41127906
64CHD1_26751641_Chip-Seq_LNCaP_Human1.40594093
65RUNX_20019798_ChIP-Seq_JUKART_Human1.40559986
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40555886
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37807721
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36290163
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.35702067
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35073629
71XRN2_22483619_ChIP-Seq_HELA_Human1.35020413
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34993732
73* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34856766
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.34720325
75* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34656127
76* CLOCK_20551151_ChIP-Seq_293T_Human1.33804384
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32879301
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29707796
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.29557504
80VDR_24763502_ChIP-Seq_THP-1_Human1.29343267
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29197834
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29036231
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28010734
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27783137
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27198499
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26549045
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26332556
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24503861
89* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24436511
90MYB_26560356_Chip-Seq_TH1_Human1.24109499
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.23605919
92* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22327086
93VDR_24787735_ChIP-Seq_THP-1_Human1.21710531
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21506549
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21334106
96TTF2_22483619_ChIP-Seq_HELA_Human1.20238445
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19931439
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19919394
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18544298
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18256755
101ATF3_27146783_Chip-Seq_COLON_Human1.18080313
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.17496266
103CIITA_25753668_ChIP-Seq_RAJI_Human1.16669426
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14102750
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13567913
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13256048
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12721045
108GABP_19822575_ChIP-Seq_HepG2_Human1.11870871
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11255160
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10957687
111PU_27001747_Chip-Seq_BMDM_Mouse1.09243956
112ER_23166858_ChIP-Seq_MCF-7_Human1.09187465
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08310979
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07799766
115* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07742372
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07397526
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06529226
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05179493
119* VDR_23849224_ChIP-Seq_CD4+_Human1.03454275
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01458263
121UBF1/2_26484160_Chip-Seq_HMECs_Human1.00920561
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00391244
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00383387
124TCF7_22412390_ChIP-Seq_EML_Mouse0.99911251
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99351505
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99033406
127TAF15_26573619_Chip-Seq_HEK293_Human0.98338620
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97906693
129THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97668998
130* BRD4_25478319_ChIP-Seq_HGPS_Human0.96087161
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.93813362
132VDR_21846776_ChIP-Seq_THP-1_Human0.92699717
133* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91094444
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88889724
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88621272
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88196488
137RUNX1_22412390_ChIP-Seq_EML_Mouse0.87396486
138* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86553843
139* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85725734
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85457203
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85457203
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.83927923
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.83867914
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.82871322
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.81891322
146SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81814767
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80796183
148* ELF5_23300383_ChIP-Seq_T47D_Human0.80091522
149* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78748478
150* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.78445351
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78020430
152NELFA_20434984_ChIP-Seq_ESCs_Mouse0.77967596
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77909713
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77605114
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76887162
156NFE2_27457419_Chip-Seq_LIVER_Mouse0.75880723
157* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75692159
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.75426046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.94465658
2MP0008057_abnormal_DNA_replication2.89479374
3MP0002009_preneoplasia2.69789640
4MP0003705_abnormal_hypodermis_morpholog2.61688829
5MP0002396_abnormal_hematopoietic_system2.61601688
6MP0000383_abnormal_hair_follicle2.52692114
7MP0010234_abnormal_vibrissa_follicle2.46407305
8MP0010678_abnormal_skin_adnexa2.27561074
9MP0005451_abnormal_body_composition2.27226981
10MP0001835_abnormal_antigen_presentation2.25007062
11MP0005171_absent_coat_pigmentation2.17430883
12MP0000920_abnormal_myelination2.04795134
13MP0003303_peritoneal_inflammation2.02571039
14MP0008438_abnormal_cutaneous_collagen1.98150237
15MP0002452_abnormal_antigen_presenting1.91114695
16MP0005000_abnormal_immune_tolerance1.89867977
17MP0001800_abnormal_humoral_immune1.89160343
18MP0003136_yellow_coat_color1.88461490
19MP0003566_abnormal_cell_adhesion1.81539902
20MP0004808_abnormal_hematopoietic_stem1.79919836
21MP0002060_abnormal_skin_morphology1.75100960
22MP0005387_immune_system_phenotype1.74926570
23MP0001790_abnormal_immune_system1.74926570
24MP0002419_abnormal_innate_immunity1.74277683
25MP0009697_abnormal_copulation1.73637904
26MP0002723_abnormal_immune_serum1.71796780
27MP0010307_abnormal_tumor_latency1.70977297
28MP0005409_darkened_coat_color1.66175579
29MP0009785_altered_susceptibility_to1.63692497
30MP0002420_abnormal_adaptive_immunity1.57017208
31MP0001819_abnormal_immune_cell1.55131058
32MP0004233_abnormal_muscle_weight1.54785989
33MP0000733_abnormal_muscle_development1.52737660
34MP0006082_CNS_inflammation1.52215153
35MP0005671_abnormal_response_to1.50598031
36MP0002148_abnormal_hypersensitivity_rea1.50378288
37MP0005025_abnormal_response_to1.49134231
38MP0010094_abnormal_chromosome_stability1.48166318
39MP0005174_abnormal_tail_pigmentation1.46763287
40MP0003763_abnormal_thymus_physiology1.41314680
41MP0004185_abnormal_adipocyte_glucose1.41291409
42MP0000685_abnormal_immune_system1.40749425
43MP0002398_abnormal_bone_marrow1.40008417
44MP0004134_abnormal_chest_morphology1.39622335
45MP0002796_impaired_skin_barrier1.39172422
46MP0010352_gastrointestinal_tract_polyps1.37836854
47MP0003950_abnormal_plasma_membrane1.35490676
48MP0003436_decreased_susceptibility_to1.34473465
49MP0003656_abnormal_erythrocyte_physiolo1.33653246
50MP0003091_abnormal_cell_migration1.31690596
51MP0001851_eye_inflammation1.29571893
52MP0000716_abnormal_immune_system1.29392402
53MP0002166_altered_tumor_susceptibility1.28247871
54MP0003077_abnormal_cell_cycle1.26920168
55MP0000627_abnormal_mammary_gland1.25698171
56MP0005501_abnormal_skin_physiology1.24900097
57MP0001730_embryonic_growth_arrest1.23446359
58MP0003300_gastrointestinal_ulcer1.23244008
59MP0003868_abnormal_feces_composition1.22970574
60MP0003111_abnormal_nucleus_morphology1.20837330
61MP0001881_abnormal_mammary_gland1.20152979
62MP0004947_skin_inflammation1.19329350
63MP0004381_abnormal_hair_follicle1.19117164
64MP0003448_altered_tumor_morphology1.19078216
65MP0000465_gastrointestinal_hemorrhage1.18952744
66MP0005464_abnormal_platelet_physiology1.18311417
67MP0002006_tumorigenesis1.17518345
68MP0000689_abnormal_spleen_morphology1.16843698
69MP0005621_abnormal_cell_physiology1.15688331
70MP0003191_abnormal_cellular_cholesterol1.15281662
71MP0009384_cardiac_valve_regurgitation1.14688067
72MP0000490_abnormal_crypts_of1.13839259
73MP0002722_abnormal_immune_system1.12357467
74MP0000703_abnormal_thymus_morphology1.09464183
75MP0002405_respiratory_system_inflammati1.09211994
76MP0002019_abnormal_tumor_incidence1.08896394
77MP0004957_abnormal_blastocyst_morpholog1.08524900
78MP0003984_embryonic_growth_retardation1.08134455
79MP0001697_abnormal_embryo_size1.07972586
80MP0009379_abnormal_foot_pigmentation1.07969824
81MP0005623_abnormal_meninges_morphology1.07617518
82MP0003937_abnormal_limbs/digits/tail_de1.06899043
83MP0003806_abnormal_nucleotide_metabolis1.06835516
84MP0005058_abnormal_lysosome_morphology1.06325929
85MP0001299_abnormal_eye_distance/1.04951946
86MP0003690_abnormal_glial_cell1.04707594
87MP0000015_abnormal_ear_pigmentation1.04371485
88MP0002088_abnormal_embryonic_growth/wei1.03821142
89MP0002933_joint_inflammation1.03691483
90MP0002086_abnormal_extraembryonic_tissu1.02650607
91MP0001873_stomach_inflammation1.02613068
92MP0008007_abnormal_cellular_replicative1.02515343
93MP0002429_abnormal_blood_cell1.02181740
94MP0002080_prenatal_lethality1.00695673
95MP0001672_abnormal_embryogenesis/_devel1.00599623
96MP0005380_embryogenesis_phenotype1.00599623
97MP0005408_hypopigmentation1.00443663
98MP0001533_abnormal_skeleton_physiology0.97687639
99MP0003453_abnormal_keratinocyte_physiol0.97529090
100MP0000372_irregular_coat_pigmentation0.97037617
101MP0000569_abnormal_digit_pigmentation0.96682686
102MP0001661_extended_life_span0.96481310
103MP0004264_abnormal_extraembryonic_tissu0.96259824
104MP0001545_abnormal_hematopoietic_system0.94112764
105MP0005397_hematopoietic_system_phenotyp0.94112764
106MP0002102_abnormal_ear_morphology0.94029589
107MP0001293_anophthalmia0.93592379
108MP0010155_abnormal_intestine_physiology0.92795809
109MP0001853_heart_inflammation0.92716186
110MP0005275_abnormal_skin_tensile0.92460748
111MP0002095_abnormal_skin_pigmentation0.92154462
112MP0000858_altered_metastatic_potential0.91985043
113MP0000350_abnormal_cell_proliferation0.90625948
114MP0005257_abnormal_intraocular_pressure0.90611639
115MP0000371_diluted_coat_color0.90547802
116MP0003828_pulmonary_edema0.90291177
117MP0000647_abnormal_sebaceous_gland0.90124740
118MP0005384_cellular_phenotype0.88779393
119MP0000313_abnormal_cell_death0.88763263
120MP0003941_abnormal_skin_development0.88461386
121MP0009333_abnormal_splenocyte_physiolog0.88342880
122MP0001348_abnormal_lacrimal_gland0.88215455
123MP0000377_abnormal_hair_follicle0.87480638
124MP0000432_abnormal_head_morphology0.87427897
125MP0008058_abnormal_DNA_repair0.85308882
126MP0002938_white_spotting0.85164979
127MP0003693_abnormal_embryo_hatching0.84439365
128MP0005076_abnormal_cell_differentiation0.84188910
129MP0005666_abnormal_adipose_tissue0.83386073
130MP0009931_abnormal_skin_appearance0.82650542
131MP0004272_abnormal_basement_membrane0.81935943
132MP0003172_abnormal_lysosome_physiology0.81043093
133MP0004742_abnormal_vestibular_system0.80601319
134MP0009278_abnormal_bone_marrow0.80134466
135MP0006054_spinal_hemorrhage0.79865417
136MP0001216_abnormal_epidermal_layer0.78994196
137MP0004782_abnormal_surfactant_physiolog0.78881519
138MP0001186_pigmentation_phenotype0.78620265
139MP0002998_abnormal_bone_remodeling0.77516461
140MP0003724_increased_susceptibility_to0.77083296
141MP0002092_abnormal_eye_morphology0.76606821
142MP0004197_abnormal_fetal_growth/weight/0.75734940
143MP0008932_abnormal_embryonic_tissue0.75581200
144MP0001915_intracranial_hemorrhage0.74912378
145MP0001191_abnormal_skin_condition0.73150416
146MP0005375_adipose_tissue_phenotype0.73066964
147MP0001727_abnormal_embryo_implantation0.71707511
148MP0000003_abnormal_adipose_tissue0.71377129
149MP0003786_premature_aging0.71287194
150MP0005023_abnormal_wound_healing0.70766519
151MP0002970_abnormal_white_adipose0.70532488
152MP0000358_abnormal_cell_content/0.69640877
153MP0005220_abnormal_exocrine_pancreas0.69429772
154MP0009250_abnormal_appendicular_skeleto0.69336928
155MP0005390_skeleton_phenotype0.69278099
156MP0003943_abnormal_hepatobiliary_system0.67955516

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)3.88309382
2Recurrent abscess formation (HP:0002722)3.03505930
3Absent frontal sinuses (HP:0002688)3.00786365
4Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.97449936
5Insidious onset (HP:0003587)2.90955513
6Termporal pattern (HP:0011008)2.90955513
7Small epiphyses (HP:0010585)2.88047143
8Degeneration of the lateral corticospinal tracts (HP:0002314)2.86385995
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.86385995
10Volvulus (HP:0002580)2.81005392
11Thick nail (HP:0001805)2.79998228
12Deep philtrum (HP:0002002)2.79833286
13Premature rupture of membranes (HP:0001788)2.78349494
14Chronic otitis media (HP:0000389)2.75036947
15Cellulitis (HP:0100658)2.70490197
16Abnormality of the frontal sinuses (HP:0002687)2.69429650
17Microglossia (HP:0000171)2.65653059
18Thrombocytosis (HP:0001894)2.64939966
19Recurrent bacterial skin infections (HP:0005406)2.63911809
20Fatigue (HP:0012378)2.63260052
21Osteolytic defects of the hand bones (HP:0009699)2.61535052
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.61535052
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55581668
24Missing ribs (HP:0000921)2.51157441
25Hematochezia (HP:0002573)2.48005697
26Onycholysis (HP:0001806)2.44232868
27Recurrent pneumonia (HP:0006532)2.41406859
28Ankyloglossia (HP:0010296)2.40671762
29Hyperacusis (HP:0010780)2.40606132
30Colitis (HP:0002583)2.38210702
31Viral hepatitis (HP:0006562)2.33761533
32Eczematoid dermatitis (HP:0000976)2.33641793
33Progressive muscle weakness (HP:0003323)2.33613017
34Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.32036858
35Reticulocytopenia (HP:0001896)2.31907206
36Asymmetry of the thorax (HP:0001555)2.31388512
37Abnormality of the intrinsic pathway (HP:0010989)2.28437837
38Selective tooth agenesis (HP:0001592)2.26168404
39Flat acetabular roof (HP:0003180)2.25605319
40Abnormality of oral frenula (HP:0000190)2.24767327
41Sparse lateral eyebrow (HP:0005338)2.22231579
42Vertebral compression fractures (HP:0002953)2.22131420
43Milia (HP:0001056)2.21655289
44Prostate neoplasm (HP:0100787)2.21291985
45Elbow flexion contracture (HP:0002987)2.20845933
46Short nail (HP:0001799)2.20518075
47Syringomyelia (HP:0003396)2.19114915
48Spinal cord lesions (HP:0100561)2.19114915
4911 pairs of ribs (HP:0000878)2.18829047
50Abnormal foot bone ossification (HP:0010675)2.18364732
51White forelock (HP:0002211)2.16951360
52Duplicated collecting system (HP:0000081)2.16063706
53Large earlobe (HP:0009748)2.15273485
54Abnormality of macrophages (HP:0004311)2.15174043
55Autoimmune hemolytic anemia (HP:0001890)2.15139862
56Overlapping toe (HP:0001845)2.15016090
57Osteomyelitis (HP:0002754)2.14701550
58Protrusio acetabuli (HP:0003179)2.14679545
59Achilles tendon contracture (HP:0001771)2.14028281
60Abnormality of the thoracic spine (HP:0100711)2.13868190
61Recurrent viral infections (HP:0004429)2.11304802
62Subacute progressive viral hepatitis (HP:0006572)2.10832462
63Lower limb hyperreflexia (HP:0002395)2.10304022
64Atrophic scars (HP:0001075)2.08477328
65Epiphyseal dysplasia (HP:0002656)2.08448395
66Hypokinesia (HP:0002375)2.08006375
67Acute lymphatic leukemia (HP:0006721)2.07279557
68Agammaglobulinemia (HP:0004432)2.05472877
69Disinhibition (HP:0000734)2.05309808
70Insomnia (HP:0100785)2.05028805
71Multiple enchondromatosis (HP:0005701)2.04800879
72Recurrent skin infections (HP:0001581)2.04486168
73Obstructive lung disease (HP:0006536)2.02851917
74Chronic obstructive pulmonary disease (HP:0006510)2.02851917
75Pallor (HP:0000980)2.02849384
76Broad face (HP:0000283)2.02475731
77Fragile skin (HP:0001030)2.01847920
78Abnormality of the columella (HP:0009929)2.00768159
79Myelodysplasia (HP:0002863)2.00266908
80Ectopic kidney (HP:0000086)1.97717454
81Ridged nail (HP:0001807)1.97688742
82Abnormality of the Achilles tendon (HP:0005109)1.96650730
83Patchy hypopigmentation of hair (HP:0011365)1.95103888
84Relative macrocephaly (HP:0004482)1.94534690
85Abnormality of the gastric mucosa (HP:0004295)1.94478977
86Capillary hemangiomas (HP:0005306)1.92578888
87Abnormality of the renal collecting system (HP:0004742)1.92500299
88Abnormality of nail color (HP:0100643)1.92059922
89Increased density of long bones (HP:0006392)1.92009950
90Chromsome breakage (HP:0040012)1.91311368
91Recurrent lower respiratory tract infections (HP:0002783)1.91054075
92B lymphocytopenia (HP:0010976)1.90727969
93Thoracic kyphosis (HP:0002942)1.90552516
94Blepharitis (HP:0000498)1.90213203
95Acute myeloid leukemia (HP:0004808)1.89898636
96Asplenia (HP:0001746)1.89591723
97Abnormality of incisor morphology (HP:0011063)1.88800072
98Sensory axonal neuropathy (HP:0003390)1.88246083
99Wormian bones (HP:0002645)1.87740737
100Periodontitis (HP:0000704)1.87632509
101Ulnar bowing (HP:0003031)1.86979395
102Nonimmune hydrops fetalis (HP:0001790)1.86969683
103Supernumerary ribs (HP:0005815)1.86892825
104Sandal gap (HP:0001852)1.85698692
105Thyroiditis (HP:0100646)1.85541303
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83833068
107Hypoplastic ischia (HP:0003175)1.83423862
108Micronodular cirrhosis (HP:0001413)1.83332137
109Stomatitis (HP:0010280)1.83287351
110IgM deficiency (HP:0002850)1.83185839
111Prominent nose (HP:0000448)1.82949227
112Chin dimple (HP:0010751)1.82660208
113Progressive external ophthalmoplegia (HP:0000590)1.81798844
114Reduced antithrombin III activity (HP:0001976)1.80906830
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.79854083
116Persistence of primary teeth (HP:0006335)1.79089553
117Ankle contracture (HP:0006466)1.78572170
118Microvesicular hepatic steatosis (HP:0001414)1.77356509
119Trismus (HP:0000211)1.77325718
120Limited elbow extension (HP:0001377)1.77064803
121Abnormality of the acetabulum (HP:0003170)1.77044598
122Meningitis (HP:0001287)1.75880091
123Spondylolisthesis (HP:0003302)1.75058434
124Agnosia (HP:0010524)1.74816599
125Septate vagina (HP:0001153)1.74592742
126Abnormality of the prostate (HP:0008775)1.73823332
127Mediastinal lymphadenopathy (HP:0100721)1.73076775
128Long clavicles (HP:0000890)1.71952282
129Hepatosplenomegaly (HP:0001433)1.71488495
130Premature skin wrinkling (HP:0100678)1.70853641
131Abnormality of the incisor (HP:0000676)1.70658229
132Supernumerary bones of the axial skeleton (HP:0009144)1.70162337
133Urethral obstruction (HP:0000796)1.69591054
134Esophageal atresia (HP:0002032)1.69443531
135Aplasia cutis congenita (HP:0001057)1.67814682
136Back pain (HP:0003418)1.66788044
137IgA deficiency (HP:0002720)1.66282730
138Abnormality of the common coagulation pathway (HP:0010990)1.65917433
139Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65775783
140Orthostatic hypotension (HP:0001278)1.63962114
141Gastrointestinal inflammation (HP:0004386)1.63727801
142Hepatitis (HP:0012115)1.63335008
143Recurrent fungal infections (HP:0002841)1.62886012
144Pseudobulbar signs (HP:0002200)1.62134255
145Increased nuchal translucency (HP:0010880)1.61812021
146Centrally nucleated skeletal muscle fibers (HP:0003687)1.61544831
147Abnormal cartilage morphology (HP:0002763)1.60156615
148Coarse hair (HP:0002208)1.60132565
149Spinal cord compression (HP:0002176)1.59569294
150Glossoptosis (HP:0000162)1.58539755
151Hypoplasia of the iris (HP:0007676)1.58392366
152Increased connective tissue (HP:0009025)1.58355313
153Abnormality of cells of the erythroid lineage (HP:0012130)1.58075598
154Reduced subcutaneous adipose tissue (HP:0003758)1.57990773
155Dysmetric saccades (HP:0000641)1.57116480
156Slender build (HP:0001533)1.56882429
157Gastrointestinal stroma tumor (HP:0100723)1.56551293
158Inflammation of the large intestine (HP:0002037)1.56354991
159Follicular hyperkeratosis (HP:0007502)1.56063392
160Cupped ear (HP:0000378)1.55575276
161Abnormality of the antihelix (HP:0009738)1.55502400
162Microtia (HP:0008551)1.55491710
163Heterotopia (HP:0002282)1.55195352
164Flared metaphyses (HP:0003015)1.55068683
165Alopecia of scalp (HP:0002293)1.54629313
166Hypoplastic pelvis (HP:0008839)1.52219309
167Abnormality of the 2nd finger (HP:0004100)1.52096615
168Abnormal auditory evoked potentials (HP:0006958)1.51216924
169Lymphopenia (HP:0001888)1.50512520
170Recurrent bronchitis (HP:0002837)1.50354261
171Chronic mucocutaneous candidiasis (HP:0002728)1.49273575
172Recurrent cutaneous fungal infections (HP:0011370)1.49273575
173Optic neuritis (HP:0100653)1.48853795
174Retrobulbar optic neuritis (HP:0100654)1.48853795
175Proximal placement of thumb (HP:0009623)1.48821103
176Abnormal platelet volume (HP:0011876)1.47721059
177Arterial tortuosity (HP:0005116)1.47236326
178Abnormality of primary teeth (HP:0006481)1.46546494
179Conical tooth (HP:0000698)1.45440995
180Myositis (HP:0100614)1.44837504
181Vasculitis (HP:0002633)1.44356252
182Deviation of the thumb (HP:0009603)1.44238761
183Scapular winging (HP:0003691)1.44236659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.07110287
2BRD42.79636187
3PBK2.73275849
4EIF2AK12.64228582
5STK392.44608681
6IRAK42.37727732
7MKNK12.23095570
8FGR2.18306342
9PRPF4B2.13734832
10RIPK42.09941438
11EPHB12.08936591
12TRIB32.07587244
13PNCK1.98724321
14MST41.96100681
15NEK91.91582675
16CDK121.82691367
17SMG11.82266229
18CSF1R1.80663725
19CDC71.78552416
20CLK11.66522438
21BMPR21.66412015
22MKNK21.57261190
23STK101.55337546
24JAK31.52131084
25ERN11.51523668
26SRPK11.50976277
27TSSK61.47164716
28KIT1.46500153
29BLK1.43429443
30MAP3K141.41588874
31NEK11.38926543
32SIK11.37946847
33BUB11.36135502
34STK41.34583126
35MUSK1.32696648
36ICK1.32622989
37FGFR21.31277136
38IKBKB1.25736046
39PKN11.23146664
40STK31.19786320
41PKN21.19773801
42RPS6KA51.19726165
43BRSK21.19665078
44NUAK11.18236753
45TEC1.18012798
46FES1.17065598
47PDGFRA1.16044415
48MAP3K101.14033605
49TRPM71.12485722
50TGFBR21.09597227
51MELK1.08532885
52RPS6KA41.08330425
53MAP4K11.07180149
54MAP3K131.06959993
55TLK11.05938082
56MAP2K31.05517054
57EPHA21.05322220
58MET1.04158491
59TNIK1.03367400
60RAF11.02321774
61BTK1.02300026
62LCK1.01697171
63NME21.00986221
64EIF2AK20.98348913
65LYN0.97672256
66TAF10.97057717
67MTOR0.96495592
68TTN0.94703083
69PIM20.94254657
70NEK20.93521366
71CDK40.92223034
72MAPKAPK50.91547589
73IKBKE0.91093677
74HCK0.91084671
75ZAK0.91035943
76CAMK1G0.90971681
77ARAF0.89194118
78CDK90.89024827
79TTK0.86822904
80ITK0.85502831
81CDK80.85307787
82EIF2AK30.85111877
83LATS10.83265936
84PDGFRB0.82724985
85RPS6KB20.82608290
86TXK0.81435506
87FLT30.80793091
88WEE10.80714922
89SCYL20.79687380
90CSK0.79185451
91TYK20.77667500
92IRAK30.76456400
93PRKCQ0.75885705
94OXSR10.75435542
95MARK30.71913296
96SYK0.71865727
97MAP3K80.71275353
98ABL20.71173822
99CDK60.70764275
100PAK40.69332728
101ATR0.69084541
102TBK10.68242620
103MAPK110.66808473
104CAMK1D0.66430726
105CSNK1A1L0.66234378
106ILK0.65757480
107ERBB40.65278741
108PAK20.64652872
109CHEK20.64610619
110MAP3K120.63953229
111ATM0.63127757
112CHUK0.62663956
113AURKB0.62526699
114YES10.62184993
115CSNK1D0.62083542
116PTK20.61858258
117VRK10.61690318
118IRAK10.60614910
119CHEK10.59752557
120CCNB10.59166823
121LRRK20.58922562
122PIM10.58921321
123IRAK20.58395498
124DMPK0.57925952
125MAP3K10.57382672
126INSR0.57062350
127CDK70.57018185
128EEF2K0.56535738
129SIK20.56173614
130FRK0.55822589
131GRK70.55557213
132ROCK20.54610555
133TAOK30.53334623
134TAOK20.53076640
135STK240.49996154
136ABL10.48701841
137PRKCI0.48648436
138JAK10.48644491
139AURKA0.48426527
140EGFR0.47479262
141LATS20.46001422
142MAP3K60.45768464
143PLK10.45211383
144CSNK2A20.40581520
145MOS0.39150429
146BRAF0.37502010
147CDK20.37220757
148MAP3K20.35515402
149TESK10.35304242
150ALK0.34797223
151KSR10.34744806
152CDK10.33837071

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.61158853
2One carbon pool by folate_Homo sapiens_hsa006702.10366043
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.01760646
4Systemic lupus erythematosus_Homo sapiens_hsa053221.86069848
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85080274
6B cell receptor signaling pathway_Homo sapiens_hsa046621.84045613
7Non-small cell lung cancer_Homo sapiens_hsa052231.80996691
8Non-homologous end-joining_Homo sapiens_hsa034501.77696868
9Thyroid cancer_Homo sapiens_hsa052161.67275051
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66775221
11Leishmaniasis_Homo sapiens_hsa051401.64354679
12Ribosome_Homo sapiens_hsa030101.63730761
13Ether lipid metabolism_Homo sapiens_hsa005651.59886302
14Osteoclast differentiation_Homo sapiens_hsa043801.58796907
15Steroid biosynthesis_Homo sapiens_hsa001001.54032595
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52701177
17N-Glycan biosynthesis_Homo sapiens_hsa005101.52595767
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50762818
19Measles_Homo sapiens_hsa051621.49123264
20Bladder cancer_Homo sapiens_hsa052191.48734148
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47043501
22Spliceosome_Homo sapiens_hsa030401.45580821
23Malaria_Homo sapiens_hsa051441.45247835
24Primary immunodeficiency_Homo sapiens_hsa053401.41179678
25Pyrimidine metabolism_Homo sapiens_hsa002401.40688504
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39640741
27Hematopoietic cell lineage_Homo sapiens_hsa046401.33722053
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33022029
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32891920
30Pentose phosphate pathway_Homo sapiens_hsa000301.30971026
31MicroRNAs in cancer_Homo sapiens_hsa052061.25768175
32Herpes simplex infection_Homo sapiens_hsa051681.23415105
33Viral carcinogenesis_Homo sapiens_hsa052031.22061475
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20253284
35Homologous recombination_Homo sapiens_hsa034401.19077683
36Small cell lung cancer_Homo sapiens_hsa052221.16074542
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.14464669
38Antigen processing and presentation_Homo sapiens_hsa046121.14162651
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12840605
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.12417272
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.12267761
42DNA replication_Homo sapiens_hsa030301.11391310
43Shigellosis_Homo sapiens_hsa051311.10233881
44Mismatch repair_Homo sapiens_hsa034301.09189856
45Pertussis_Homo sapiens_hsa051331.08868253
46Sphingolipid metabolism_Homo sapiens_hsa006001.07890756
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07129761
48Fanconi anemia pathway_Homo sapiens_hsa034601.06053727
49RNA transport_Homo sapiens_hsa030131.05328709
50T cell receptor signaling pathway_Homo sapiens_hsa046601.03653720
51Hepatitis B_Homo sapiens_hsa051611.03499154
52Tuberculosis_Homo sapiens_hsa051521.03071247
53ECM-receptor interaction_Homo sapiens_hsa045121.02015657
54Toxoplasmosis_Homo sapiens_hsa051451.01187165
55Protein export_Homo sapiens_hsa030601.00868542
56Endometrial cancer_Homo sapiens_hsa052131.00156514
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99363521
58Allograft rejection_Homo sapiens_hsa053300.99247217
59Cell cycle_Homo sapiens_hsa041100.99188580
60Legionellosis_Homo sapiens_hsa051340.98242817
61Salmonella infection_Homo sapiens_hsa051320.97684691
62RNA polymerase_Homo sapiens_hsa030200.97632385
63Platelet activation_Homo sapiens_hsa046110.97389565
64Basal transcription factors_Homo sapiens_hsa030220.96584212
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95578964
66Graft-versus-host disease_Homo sapiens_hsa053320.94069097
67Epstein-Barr virus infection_Homo sapiens_hsa051690.92792099
68Glioma_Homo sapiens_hsa052140.91954128
69TNF signaling pathway_Homo sapiens_hsa046680.91823222
70Viral myocarditis_Homo sapiens_hsa054160.91618723
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.91453882
72Influenza A_Homo sapiens_hsa051640.91122481
73Nucleotide excision repair_Homo sapiens_hsa034200.91072487
74Prostate cancer_Homo sapiens_hsa052150.91005684
75Asthma_Homo sapiens_hsa053100.89390385
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88781252
77RNA degradation_Homo sapiens_hsa030180.87595045
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86758705
79Chronic myeloid leukemia_Homo sapiens_hsa052200.86010405
80Renal cell carcinoma_Homo sapiens_hsa052110.85179276
81Colorectal cancer_Homo sapiens_hsa052100.84833105
82Rheumatoid arthritis_Homo sapiens_hsa053230.84496678
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83772150
84Pancreatic cancer_Homo sapiens_hsa052120.83615178
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.82887190
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82188896
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81716946
88African trypanosomiasis_Homo sapiens_hsa051430.81389004
89HTLV-I infection_Homo sapiens_hsa051660.78425246
90ErbB signaling pathway_Homo sapiens_hsa040120.77773813
91mRNA surveillance pathway_Homo sapiens_hsa030150.76754447
92p53 signaling pathway_Homo sapiens_hsa041150.76176554
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75507382
94Chemokine signaling pathway_Homo sapiens_hsa040620.75351594
95Prolactin signaling pathway_Homo sapiens_hsa049170.75227072
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74120173
97Apoptosis_Homo sapiens_hsa042100.73962889
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73697614
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73644649
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.73320060
101Autoimmune thyroid disease_Homo sapiens_hsa053200.72376316
102Base excision repair_Homo sapiens_hsa034100.71643965
103Phagosome_Homo sapiens_hsa041450.71497001
104Focal adhesion_Homo sapiens_hsa045100.71483787
105VEGF signaling pathway_Homo sapiens_hsa043700.71361920
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69299096
107Proteoglycans in cancer_Homo sapiens_hsa052050.69007549
108Biosynthesis of amino acids_Homo sapiens_hsa012300.67255026
109Other glycan degradation_Homo sapiens_hsa005110.67052262
110Hepatitis C_Homo sapiens_hsa051600.66857220
111mTOR signaling pathway_Homo sapiens_hsa041500.66417080
112Alcoholism_Homo sapiens_hsa050340.65745222
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64451724
114Sulfur metabolism_Homo sapiens_hsa009200.62145921
115Melanoma_Homo sapiens_hsa052180.62106000
116Lysine degradation_Homo sapiens_hsa003100.61667366
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61076393
118Acute myeloid leukemia_Homo sapiens_hsa052210.60500805
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60055987
120Carbon metabolism_Homo sapiens_hsa012000.59603699
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58059392
122Adherens junction_Homo sapiens_hsa045200.57820757
123TGF-beta signaling pathway_Homo sapiens_hsa043500.57185945
124Axon guidance_Homo sapiens_hsa043600.56076355
125Fructose and mannose metabolism_Homo sapiens_hsa000510.55753532
126Prion diseases_Homo sapiens_hsa050200.54317310
127Pathways in cancer_Homo sapiens_hsa052000.53276465
128Inositol phosphate metabolism_Homo sapiens_hsa005620.52056936
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51457554
130Notch signaling pathway_Homo sapiens_hsa043300.50046187
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48059259
132Proteasome_Homo sapiens_hsa030500.43433257
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41763014
134Insulin resistance_Homo sapiens_hsa049310.41094534
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.40730741
136Renin-angiotensin system_Homo sapiens_hsa046140.39673435
137Insulin signaling pathway_Homo sapiens_hsa049100.38423478
138Amoebiasis_Homo sapiens_hsa051460.36902663
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35750323
140Fatty acid biosynthesis_Homo sapiens_hsa000610.35070727

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