MTCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13936202
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13145957
3synaptic vesicle maturation (GO:0016188)4.98083506
4locomotory exploration behavior (GO:0035641)4.59104088
5positive regulation of synapse maturation (GO:0090129)4.48773604
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.47079538
7cellular potassium ion homeostasis (GO:0030007)4.23921946
8layer formation in cerebral cortex (GO:0021819)4.21159468
9regulation of synaptic vesicle exocytosis (GO:2000300)4.20004696
10regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.19583557
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.18387241
12response to pheromone (GO:0019236)4.18029149
13cerebellar Purkinje cell differentiation (GO:0021702)4.13011122
14synaptic vesicle exocytosis (GO:0016079)4.02407857
15vocalization behavior (GO:0071625)3.95088867
16neuronal action potential propagation (GO:0019227)3.89252127
17sodium ion export (GO:0071436)3.84821405
18cerebellar granule cell differentiation (GO:0021707)3.67761461
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67648950
20neurotransmitter secretion (GO:0007269)3.61940967
21neuromuscular process controlling posture (GO:0050884)3.61823682
22glutamate secretion (GO:0014047)3.61404843
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60797226
24regulation of synaptic vesicle transport (GO:1902803)3.52561312
25synaptic transmission, glutamatergic (GO:0035249)3.51223699
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46074518
27neuromuscular process controlling balance (GO:0050885)3.42771403
28protein localization to synapse (GO:0035418)3.38851626
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.37608461
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36797257
31regulation of synapse maturation (GO:0090128)3.35594606
32glutamate receptor signaling pathway (GO:0007215)3.30739741
33neuron-neuron synaptic transmission (GO:0007270)3.29785040
34paraxial mesoderm development (GO:0048339)3.24164084
35cell differentiation in hindbrain (GO:0021533)3.21649030
36cell communication by electrical coupling (GO:0010644)3.21015181
37membrane hyperpolarization (GO:0060081)3.18223530
38regulation of glutamate receptor signaling pathway (GO:1900449)3.17409744
39gamma-aminobutyric acid transport (GO:0015812)3.15664778
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13131176
41long-term memory (GO:0007616)3.09773973
42innervation (GO:0060384)3.09328484
43dendritic spine morphogenesis (GO:0060997)3.08565595
44prepulse inhibition (GO:0060134)3.07904209
45regulation of synapse structural plasticity (GO:0051823)3.05155461
46membrane depolarization during action potential (GO:0086010)3.04135011
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03873626
48cell migration in hindbrain (GO:0021535)3.03726568
49regulation of neuronal synaptic plasticity (GO:0048168)3.02901418
50potassium ion homeostasis (GO:0055075)3.01964046
51positive regulation of membrane potential (GO:0045838)3.01120960
52exploration behavior (GO:0035640)3.01105502
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00114228
54synaptic vesicle endocytosis (GO:0048488)2.98118191
55mating behavior (GO:0007617)2.95615832
56regulation of neurotransmitter secretion (GO:0046928)2.95189740
57planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93488995
58regulation of postsynaptic membrane potential (GO:0060078)2.93180376
59postsynaptic membrane organization (GO:0001941)2.92450677
60regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91149500
61auditory behavior (GO:0031223)2.90319640
62neurotransmitter transport (GO:0006836)2.88042186
63detection of calcium ion (GO:0005513)2.87251495
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.84875794
65regulation of voltage-gated calcium channel activity (GO:1901385)2.84720176
66axon extension (GO:0048675)2.84171663
67membrane repolarization (GO:0086009)2.83443780
68negative regulation of hormone biosynthetic process (GO:0032353)2.81297135
69negative regulation of hormone metabolic process (GO:0032351)2.81297135
70neuron cell-cell adhesion (GO:0007158)2.80977266
71phosphorelay signal transduction system (GO:0000160)2.80818439
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80275409
73neuromuscular process (GO:0050905)2.80273472
74positive regulation of neurotransmitter transport (GO:0051590)2.79683668
75neurotransmitter-gated ion channel clustering (GO:0072578)2.79602791
76chemosensory behavior (GO:0007635)2.78827547
77positive regulation of dendritic spine morphogenesis (GO:0061003)2.77733147
78neuronal ion channel clustering (GO:0045161)2.75936375
79response to auditory stimulus (GO:0010996)2.75315926
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74661724
81regulation of neurotransmitter transport (GO:0051588)2.73925454
82transmission of nerve impulse (GO:0019226)2.72541457
83pre-miRNA processing (GO:0031054)2.72261722
84axonal fasciculation (GO:0007413)2.72050075
85potassium ion import (GO:0010107)2.72008149
86adherens junction assembly (GO:0034333)2.71811226
87neuron recognition (GO:0008038)2.70036696
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.68362810
89neuron projection extension (GO:1990138)2.65870692
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65628379
91regulation of clathrin-mediated endocytosis (GO:2000369)2.63846706
92cerebellar Purkinje cell layer development (GO:0021680)2.63557536
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62667136
94bone trabecula formation (GO:0060346)2.62577911
95adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60834673
96establishment of nucleus localization (GO:0040023)2.60694375
97regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60656040
98neuromuscular synaptic transmission (GO:0007274)2.60131593
99activation of protein kinase A activity (GO:0034199)2.60090247
100protein heterotrimerization (GO:0070208)2.59231999
101myelination in peripheral nervous system (GO:0022011)2.59150928
102peripheral nervous system axon ensheathment (GO:0032292)2.59150928
103behavioral response to ethanol (GO:0048149)2.58470195
104dopamine receptor signaling pathway (GO:0007212)2.58206289
105membrane depolarization (GO:0051899)2.58172936
106striatum development (GO:0021756)2.56649746
107synapse assembly (GO:0007416)2.56568568
108regulation of axon extension involved in axon guidance (GO:0048841)2.54644523
109amino acid import (GO:0043090)2.54140870
110protein retention in ER lumen (GO:0006621)2.53758971
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.53727488
112positive regulation of neurotransmitter secretion (GO:0001956)2.53270352
113negative regulation of catenin import into nucleus (GO:0035414)2.53267232
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53248043
115regulation of posttranscriptional gene silencing (GO:0060147)2.50938739
116regulation of gene silencing by miRNA (GO:0060964)2.50938739
117regulation of gene silencing by RNA (GO:0060966)2.50938739
118regulation of neurotransmitter levels (GO:0001505)2.50639865
119regulation of calcium ion-dependent exocytosis (GO:0017158)2.50575221
120cell-substrate adherens junction assembly (GO:0007045)2.50543405
121focal adhesion assembly (GO:0048041)2.50543405
122adult walking behavior (GO:0007628)2.49901343
123semaphorin-plexin signaling pathway (GO:0071526)2.49208335
124collagen fibril organization (GO:0030199)2.47896475
125regulation of mitotic spindle organization (GO:0060236)2.46975150
126skin morphogenesis (GO:0043589)2.46024211
127establishment or maintenance of monopolar cell polarity (GO:0061339)2.44645668
128establishment of monopolar cell polarity (GO:0061162)2.44645668
129regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44347246
130membrane assembly (GO:0071709)2.43366366
131apical protein localization (GO:0045176)2.40535980
132notochord development (GO:0030903)2.40289260
133positive regulation of dendritic spine development (GO:0060999)2.37955422
134developmental cell growth (GO:0048588)2.37794637
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.37335509
136cell adhesion mediated by integrin (GO:0033627)2.36704125
137establishment of apical/basal cell polarity (GO:0035089)2.36453806
138positive regulation of synapse assembly (GO:0051965)2.35488293
139actin filament depolymerization (GO:0030042)2.34334752
140hippo signaling (GO:0035329)2.33887895
141cell-substrate junction assembly (GO:0007044)2.32921834
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31873543
143cell migration involved in sprouting angiogenesis (GO:0002042)2.31599358
144neural tube development (GO:0021915)2.29503731
145convergent extension (GO:0060026)2.29480144
146chondrocyte proliferation (GO:0035988)2.29293495
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26623559
148protein targeting to plasma membrane (GO:0072661)2.22818392
149kidney mesenchyme development (GO:0072074)2.21569151
150regulation of synaptic plasticity (GO:0048167)2.20629632
151positive regulation of dendrite development (GO:1900006)2.19616716
152polarized epithelial cell differentiation (GO:0030859)2.19350578
153hemidesmosome assembly (GO:0031581)2.18677635
154mesenchymal-epithelial cell signaling (GO:0060638)2.18213162
155activation of Rac GTPase activity (GO:0032863)2.17956959
156regulation of axon guidance (GO:1902667)2.16318392
157endothelial cell morphogenesis (GO:0001886)2.15393149
158positive regulation of axon extension (GO:0045773)2.15089404
159glucocorticoid receptor signaling pathway (GO:0042921)2.14001887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.56528142
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.10167010
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.05388278
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.67286109
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.66441782
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.63612038
7DROSHA_22980978_ChIP-Seq_HELA_Human2.55681432
8REST_21632747_ChIP-Seq_MESCs_Mouse2.54313027
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46076764
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24616379
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24472763
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24239330
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24239330
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20761623
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18512543
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.18410114
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16953363
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16323572
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11497338
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10739544
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.04375332
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95809999
23KDM2B_26808549_Chip-Seq_K562_Human1.94376854
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.93518246
25GBX2_23144817_ChIP-Seq_PC3_Human1.89787675
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89602161
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.87672885
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.85799749
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85072113
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83888301
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83303010
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.76882207
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.76659265
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73455750
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73441723
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71363492
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71363492
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71363492
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69450167
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.65708497
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63527829
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62743203
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62453567
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.59624853
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58578483
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57178076
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55284143
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54616758
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52820926
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50971993
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.50572566
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48922948
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.47899224
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47761468
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46175860
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43631294
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.43579455
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39520643
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38614113
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38383550
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38094293
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37658983
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35761355
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.35613097
65AR_19668381_ChIP-Seq_PC3_Human1.31290632
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31016901
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29528585
68SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29121977
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28227249
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28044085
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.27872917
72TP53_23651856_ChIP-Seq_MEFs_Mouse1.26758089
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26621958
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25700151
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25515544
76TP53_22127205_ChIP-Seq_IMR90_Human1.24739296
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24476004
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.23370213
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23336521
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22305777
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20215912
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.19587194
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17831901
84POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15970084
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15358126
86CLOCK_20551151_ChIP-Seq_293T_Human1.13969614
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13556951
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13526039
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11971199
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11139376
91TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10430535
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08823096
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08748503
94ZNF274_21170338_ChIP-Seq_K562_Hela1.08442585
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07844028
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07739903
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07518817
98LXR_22292898_ChIP-Seq_THP-1_Human1.07097981
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06494706
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.06153843
101TP53_18474530_ChIP-ChIP_U2OS_Human1.05706846
102BRD4_25478319_ChIP-Seq_HGPS_Human1.05674220
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04907907
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04369294
105RACK7_27058665_Chip-Seq_MCF-7_Human1.02726972
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.01611440
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00921620
108CTCF_27219007_Chip-Seq_Bcells_Human1.00213834
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.00103380
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00091859
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99683522
112ZNF263_19887448_ChIP-Seq_K562_Human0.99434947
113BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99302113
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.99243108
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98867281
116SMAD4_21799915_ChIP-Seq_A2780_Human0.98734735
117TP53_16413492_ChIP-PET_HCT116_Human0.97925404
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97396198
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.97125220
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.96282749
121STAT3_23295773_ChIP-Seq_U87_Human0.95994975
122CREB1_26743006_Chip-Seq_LNCaP_Human0.95860973
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.95046120
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94454014
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94370071
126AHR_22903824_ChIP-Seq_MCF-7_Human0.94266319
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92318035
128SOX9_26525672_Chip-Seq_HEART_Mouse0.91747957
129RNF2_27304074_Chip-Seq_NSC_Mouse0.90561301
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90186286
131KDM2B_26808549_Chip-Seq_DND41_Human0.90121789
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.89727868
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.89679085
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87955749
135UBF1/2_26484160_Chip-Seq_HMECs_Human0.87507180
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.83941406
137AR_21909140_ChIP-Seq_LNCAP_Human0.83931625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.26599463
2MP0008438_abnormal_cutaneous_collagen3.30780946
3MP0003635_abnormal_synaptic_transmissio3.10020641
4MP0003705_abnormal_hypodermis_morpholog3.09227130
5MP0004270_analgesia3.06481546
6MP0009046_muscle_twitch3.03244382
7MP0003283_abnormal_digestive_organ2.54113323
8MP0002653_abnormal_ependyma_morphology2.40132049
9MP0006072_abnormal_retinal_apoptosis2.38055454
10MP0005423_abnormal_somatic_nervous2.37014213
11MP0002063_abnormal_learning/memory/cond2.35499979
12MP0004272_abnormal_basement_membrane2.34563724
13MP0005257_abnormal_intraocular_pressure2.33557903
14MP0005551_abnormal_eye_electrophysiolog2.31449962
15MP0009745_abnormal_behavioral_response2.27946037
16MP0003880_abnormal_central_pattern2.23553818
17MP0002734_abnormal_mechanical_nocicepti2.19040852
18MP0002272_abnormal_nervous_system2.18479881
19MP0002064_seizures2.16661047
20MP0004858_abnormal_nervous_system2.15502364
21MP0001984_abnormal_olfaction2.07064448
22MP0001348_abnormal_lacrimal_gland2.06439076
23MP0001486_abnormal_startle_reflex2.03374360
24MP0002572_abnormal_emotion/affect_behav2.03333653
25MP0002822_catalepsy1.99670470
26MP0008569_lethality_at_weaning1.95740541
27MP0002184_abnormal_innervation1.92925982
28MP0001968_abnormal_touch/_nociception1.91041757
29MP0001299_abnormal_eye_distance/1.88234303
30MP0005503_abnormal_tendon_morphology1.82711462
31MP0002909_abnormal_adrenal_gland1.79280513
32MP0004145_abnormal_muscle_electrophysio1.72211981
33MP0005499_abnormal_olfactory_system1.68617021
34MP0005394_taste/olfaction_phenotype1.68617021
35MP0003279_aneurysm1.66485638
36MP0005253_abnormal_eye_physiology1.65484743
37MP0000751_myopathy1.65432346
38MP0002067_abnormal_sensory_capabilities1.64257550
39MP0006292_abnormal_olfactory_placode1.59108511
40MP0004885_abnormal_endolymph1.58459980
41MP0002733_abnormal_thermal_nociception1.56317130
42MP0003566_abnormal_cell_adhesion1.54903248
43MP0002557_abnormal_social/conspecific_i1.51477456
44MP0002882_abnormal_neuron_morphology1.50948237
45MP0000955_abnormal_spinal_cord1.50585896
46MP0001958_emphysema1.50146732
47MP0004811_abnormal_neuron_physiology1.49626636
48MP0003890_abnormal_embryonic-extraembry1.47119465
49MP0004233_abnormal_muscle_weight1.45727803
50MP0001970_abnormal_pain_threshold1.43686038
51MP0003941_abnormal_skin_development1.43117294
52MP0005623_abnormal_meninges_morphology1.40165774
53MP0000778_abnormal_nervous_system1.39016826
54MP0005275_abnormal_skin_tensile1.38852359
55MP0003942_abnormal_urinary_system1.37672060
56MP0001440_abnormal_grooming_behavior1.34947945
57MP0005409_darkened_coat_color1.32203481
58MP0002152_abnormal_brain_morphology1.30843354
59MP0003119_abnormal_digestive_system1.30189759
60MP0002735_abnormal_chemical_nociception1.29086333
61MP0003385_abnormal_body_wall1.26616054
62MP0001849_ear_inflammation1.25656683
63MP0001188_hyperpigmentation1.23512223
64MP0003787_abnormal_imprinting1.23212704
65MP0002638_abnormal_pupillary_reflex1.22303258
66MP0009780_abnormal_chondrocyte_physiolo1.22232500
67MP0002089_abnormal_postnatal_growth/wei1.20495066
68MP0002736_abnormal_nociception_after1.20391808
69MP0003879_abnormal_hair_cell1.20381310
70MP0005076_abnormal_cell_differentiation1.19721875
71MP0004133_heterotaxia1.19571352
72MP0002229_neurodegeneration1.19475965
73MP0000631_abnormal_neuroendocrine_gland1.19422968
74MP0010030_abnormal_orbit_morphology1.18827333
75MP0005386_behavior/neurological_phenoty1.18357407
76MP0004924_abnormal_behavior1.18357407
77MP0001502_abnormal_circadian_rhythm1.17834814
78MP0003091_abnormal_cell_migration1.17510477
79MP0002752_abnormal_somatic_nervous1.16721007
80MP0002066_abnormal_motor_capabilities/c1.13190586
81MP0001501_abnormal_sleep_pattern1.12919937
82MP0000579_abnormal_nail_morphology1.12417498
83MP0003861_abnormal_nervous_system1.12400464
84MP0003950_abnormal_plasma_membrane1.11654862
85MP0009250_abnormal_appendicular_skeleto1.10998498
86MP0003937_abnormal_limbs/digits/tail_de1.10349224
87MP0005645_abnormal_hypothalamus_physiol1.08687599
88MP0000013_abnormal_adipose_tissue1.07869563
89MP0005646_abnormal_pituitary_gland1.07834896
90MP0000003_abnormal_adipose_tissue1.07579460
91MP0008789_abnormal_olfactory_epithelium1.07215896
92MP0002249_abnormal_larynx_morphology1.06916366
93MP0000428_abnormal_craniofacial_morphol1.06362815
94MP0000049_abnormal_middle_ear1.05549590
95MP0009053_abnormal_anal_canal1.04905023
96MP0005187_abnormal_penis_morphology1.04563877
97MP0000733_abnormal_muscle_development1.04151965
98MP0003632_abnormal_nervous_system1.03292456
99MP0000762_abnormal_tongue_morphology1.02437382
100MP0010368_abnormal_lymphatic_system1.02298450
101MP0001485_abnormal_pinna_reflex0.99944712
102MP0000537_abnormal_urethra_morphology0.99885613
103MP0005195_abnormal_posterior_eye0.99418147
104MP0003123_paternal_imprinting0.97657330
105MP0002697_abnormal_eye_size0.97104655
106MP0002108_abnormal_muscle_morphology0.95577073
107MP0003122_maternal_imprinting0.93411570
108MP0005508_abnormal_skeleton_morphology0.92767818
109MP0009384_cardiac_valve_regurgitation0.92551038
110MP0008961_abnormal_basal_metabolism0.92535669
111MP0003755_abnormal_palate_morphology0.91513416
112MP0003115_abnormal_respiratory_system0.91475826
113MP0004043_abnormal_pH_regulation0.91311106
114MP0000462_abnormal_digestive_system0.90498624
115MP0002877_abnormal_melanocyte_morpholog0.88898289
116MP0000534_abnormal_ureter_morphology0.87692261
117MP0005391_vision/eye_phenotype0.86882558
118MP0010352_gastrointestinal_tract_polyps0.86575275
119MP0003631_nervous_system_phenotype0.85239485
120MP0008995_early_reproductive_senescence0.85222537
121MP0002060_abnormal_skin_morphology0.85179048
122MP0002896_abnormal_bone_mineralization0.84466153
123MP0002081_perinatal_lethality0.83821960
124MP0002090_abnormal_vision0.83242239
125MP0002116_abnormal_craniofacial_bone0.81764260
126MP0003935_abnormal_craniofacial_develop0.81104854
127MP0000432_abnormal_head_morphology0.80806690
128MP0004142_abnormal_muscle_tone0.80796078
129MP0004742_abnormal_vestibular_system0.79008827
130MP0003633_abnormal_nervous_system0.78770577
131MP0002234_abnormal_pharynx_morphology0.78082373
132MP0003045_fibrosis0.76854157
133MP0003121_genomic_imprinting0.76775774
134MP0005197_abnormal_uvea_morphology0.76749894
135MP0000759_abnormal_skeletal_muscle0.76363643
136MP0002114_abnormal_axial_skeleton0.75868632
137MP0010234_abnormal_vibrissa_follicle0.75771429
138MP0009672_abnormal_birth_weight0.75695989
139MP0001963_abnormal_hearing_physiology0.75000025
140MP0008877_abnormal_DNA_methylation0.74981053
141MP0000749_muscle_degeneration0.73396301
142MP0003634_abnormal_glial_cell0.73266287
143MP0002233_abnormal_nose_morphology0.72691403
144MP0006276_abnormal_autonomic_nervous0.71773808
145MP0002160_abnormal_reproductive_system0.71397274
146MP0003878_abnormal_ear_physiology0.71346803
147MP0005377_hearing/vestibular/ear_phenot0.71346803
148MP0002751_abnormal_autonomic_nervous0.70945624
149MP0002084_abnormal_developmental_patter0.70493169
150MP0001177_atelectasis0.69851696
151MP0010386_abnormal_urinary_bladder0.67187973
152MP0008872_abnormal_physiological_respon0.66977551
153MP0000569_abnormal_digit_pigmentation0.66642841
154MP0003329_amyloid_beta_deposits0.66288196

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.54792704
2Action tremor (HP:0002345)4.32438612
3Protrusio acetabuli (HP:0003179)4.22177859
4Myokymia (HP:0002411)4.17355295
5Congenital stationary night blindness (HP:0007642)3.90940627
6Focal motor seizures (HP:0011153)3.87066455
7Visual hallucinations (HP:0002367)3.78214003
8Progressive cerebellar ataxia (HP:0002073)3.75594722
9Focal seizures (HP:0007359)3.63652784
10Shallow orbits (HP:0000586)3.59215743
11Abnormality of the lower motor neuron (HP:0002366)3.54959194
12Febrile seizures (HP:0002373)3.35640050
13Gaze-evoked nystagmus (HP:0000640)3.09588649
14Dysdiadochokinesis (HP:0002075)3.02910871
15Epileptic encephalopathy (HP:0200134)3.00601950
16Bony spicule pigmentary retinopathy (HP:0007737)2.98182883
17Hemiparesis (HP:0001269)2.91970933
18Atonic seizures (HP:0010819)2.89619967
19Impaired smooth pursuit (HP:0007772)2.88868940
20Hemiplegia (HP:0002301)2.87095279
21Annular pancreas (HP:0001734)2.83799364
22Central scotoma (HP:0000603)2.82037593
23Ankle contracture (HP:0006466)2.82002784
24Atrophic scars (HP:0001075)2.78811790
25Vascular tortuosity (HP:0004948)2.77544263
26Ulnar bowing (HP:0003031)2.75408964
27Aortic dissection (HP:0002647)2.71537537
28Scotoma (HP:0000575)2.71429917
29Abnormality of ocular smooth pursuit (HP:0000617)2.69694644
30Scanning speech (HP:0002168)2.68320066
31Arterial tortuosity (HP:0005116)2.66221089
32Ependymoma (HP:0002888)2.63974827
33Dysmetric saccades (HP:0000641)2.62610984
34Abnormality of the astrocytes (HP:0100707)2.61028855
35Astrocytoma (HP:0009592)2.61028855
36Aortic aneurysm (HP:0004942)2.60387180
37Bowel diverticulosis (HP:0005222)2.59104665
38Abnormal rod and cone electroretinograms (HP:0008323)2.58623991
39Genetic anticipation (HP:0003743)2.58037294
40Absence seizures (HP:0002121)2.57924198
41Broad metatarsal (HP:0001783)2.54930875
42Bladder diverticulum (HP:0000015)2.52998706
43Abnormality of macular pigmentation (HP:0008002)2.51476935
44Obstructive sleep apnea (HP:0002870)2.48564874
45Abnormality of dentin (HP:0010299)2.47743415
46Cerebral aneurysm (HP:0004944)2.47415390
47Truncal ataxia (HP:0002078)2.45661771
48Depression (HP:0000716)2.43592607
49Fragile skin (HP:0001030)2.42763201
50Wormian bones (HP:0002645)2.41274346
51Pointed chin (HP:0000307)2.37841501
52Neoplasm of the heart (HP:0100544)2.35454730
53Neonatal short-limb short stature (HP:0008921)2.33930004
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31855671
55Lower limb amyotrophy (HP:0007210)2.31377104
56Morphological abnormality of the middle ear (HP:0008609)2.27005355
57Amblyopia (HP:0000646)2.26525582
58Ankle clonus (HP:0011448)2.26307634
59Coronal craniosynostosis (HP:0004440)2.26295153
60Mitral valve prolapse (HP:0001634)2.25349518
61Dialeptic seizures (HP:0011146)2.22150070
62Genu recurvatum (HP:0002816)2.21433709
63Pendular nystagmus (HP:0012043)2.20643416
64Poor eye contact (HP:0000817)2.20519808
65Broad face (HP:0000283)2.19596421
66Broad-based gait (HP:0002136)2.19330043
67Vertebral arch anomaly (HP:0008438)2.16568199
68Generalized tonic-clonic seizures (HP:0002069)2.16168395
69Spinal rigidity (HP:0003306)2.14299646
70Insomnia (HP:0100785)2.11845499
71Overgrowth (HP:0001548)2.11568512
72Soft skin (HP:0000977)2.11413272
73Turricephaly (HP:0000262)2.08480335
74Glioma (HP:0009733)2.08088383
75Mitral regurgitation (HP:0001653)2.07431769
76Resting tremor (HP:0002322)2.07166125
77Hypoventilation (HP:0002791)2.06376056
78Horizontal nystagmus (HP:0000666)2.04614163
79Severe visual impairment (HP:0001141)2.03988800
80Mildly elevated creatine phosphokinase (HP:0008180)2.03853807
81Hand muscle atrophy (HP:0009130)2.03330093
82Intention tremor (HP:0002080)2.01522521
83Dysmetria (HP:0001310)1.97890413
84Postural tremor (HP:0002174)1.97725960
85Abnormal social behavior (HP:0012433)1.96310506
86Impaired social interactions (HP:0000735)1.96310506
87Mild short stature (HP:0003502)1.95557828
88Aplasia involving bones of the extremities (HP:0009825)1.92682286
89Aplasia involving bones of the upper limbs (HP:0009823)1.92682286
90Aplasia of the phalanges of the hand (HP:0009802)1.92682286
91Upper limb amyotrophy (HP:0009129)1.89722612
92Distal upper limb amyotrophy (HP:0007149)1.89722612
93Wide anterior fontanel (HP:0000260)1.89303861
94Cervical subluxation (HP:0003308)1.85743897
95Decreased central vision (HP:0007663)1.85261593
96Abnormality of the labia minora (HP:0012880)1.82318997
97Distal lower limb amyotrophy (HP:0008944)1.80608575
98Type II diabetes mellitus (HP:0005978)1.80432929
99Ventricular fibrillation (HP:0001663)1.78742249
100Short nail (HP:0001799)1.78732698
101Bronchomalacia (HP:0002780)1.78072066
102Neoplasm of the oral cavity (HP:0100649)1.77443003
103Hammertoe (HP:0001765)1.77020870
104Urinary bladder sphincter dysfunction (HP:0002839)1.76586225
105Overriding aorta (HP:0002623)1.74878506
106Choroideremia (HP:0001139)1.74443966
107Renal duplication (HP:0000075)1.74315442
108Disproportionate tall stature (HP:0001519)1.73984972
109Hyperextensible skin (HP:0000974)1.73545162
110Megalencephaly (HP:0001355)1.72779545
111Aqueductal stenosis (HP:0002410)1.72591824
112Postural instability (HP:0002172)1.71330296
113Difficulty climbing stairs (HP:0003551)1.70950960
114Hyperacusis (HP:0010780)1.70948864
115Type 1 muscle fiber predominance (HP:0003803)1.69644257
116Shawl scrotum (HP:0000049)1.69467979
117Urethral obstruction (HP:0000796)1.69250907
118Aortic regurgitation (HP:0001659)1.69180919
119Supranuclear gaze palsy (HP:0000605)1.69035634
120Biconcave vertebral bodies (HP:0004586)1.68635893
121Flat cornea (HP:0007720)1.68059112
122Amyotrophic lateral sclerosis (HP:0007354)1.68019535
123Dyschromatopsia (HP:0007641)1.67758086
124Impaired vibration sensation in the lower limbs (HP:0002166)1.67281991
125Macroorchidism (HP:0000053)1.65582424
126Abnormality of the phalanges of the hallux (HP:0010057)1.65396725
127Cerebral inclusion bodies (HP:0100314)1.65196302
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.64872532
129EEG with generalized epileptiform discharges (HP:0011198)1.64766025
130Anxiety (HP:0000739)1.64737554
131Achilles tendon contracture (HP:0001771)1.64288233
132Follicular hyperkeratosis (HP:0007502)1.64080247
133Long palpebral fissure (HP:0000637)1.63870530
134Attenuation of retinal blood vessels (HP:0007843)1.62591755
135Limb dystonia (HP:0002451)1.62064737
136Epileptiform EEG discharges (HP:0011182)1.62063479
137Heterotopia (HP:0002282)1.61569972
138Diplopia (HP:0000651)1.61543337
139Abnormality of binocular vision (HP:0011514)1.61543337
140Elbow flexion contracture (HP:0002987)1.61324988
141Limb ataxia (HP:0002070)1.61295298
142Malignant neoplasm of the central nervous system (HP:0100836)1.60686478
143Tetraplegia (HP:0002445)1.60394716
144Specific learning disability (HP:0001328)1.59191492
145Neurofibrillary tangles (HP:0002185)1.59116606
146Blue sclerae (HP:0000592)1.58904785
147Joint laxity (HP:0001388)1.58691014
148Medulloblastoma (HP:0002885)1.58439252
149Renovascular hypertension (HP:0100817)1.57782376
150Obsessive-compulsive behavior (HP:0000722)1.57778610
151Bowing of the arm (HP:0006488)1.57663434
152Bowed forearm bones (HP:0003956)1.57663434
153Elfin facies (HP:0004428)1.56657120
154Absent speech (HP:0001344)1.56453302
155Increased connective tissue (HP:0009025)1.56241058
156Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55958304
157Absent frontal sinuses (HP:0002688)1.55906188
158Torticollis (HP:0000473)1.55175399
159Spastic gait (HP:0002064)1.54618088
160Thin ribs (HP:0000883)1.54429384
161Wrist flexion contracture (HP:0001239)1.53869908
162Ankyloglossia (HP:0010296)1.53195848
163Anophthalmia (HP:0000528)1.52859298
164Nervous tissue neoplasm (HP:0030060)1.52829697
165Neuroectodermal neoplasm (HP:0030061)1.52829697
166Neuroepithelial neoplasm (HP:0030063)1.52829697
167Stereotypic behavior (HP:0000733)1.52764117
168Broad long bones (HP:0005622)1.52741235
169Arnold-Chiari malformation (HP:0002308)1.52365573
170Hypsarrhythmia (HP:0002521)1.52296705
171Relative macrocephaly (HP:0004482)1.52293294
172Bradykinesia (HP:0002067)1.51050789
173Agitation (HP:0000713)1.50062636
174Long eyelashes (HP:0000527)1.49709855
175Mask-like facies (HP:0000298)1.49420393
176Posterior subcapsular cataract (HP:0007787)1.49186515
177Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.46683552
178Deviation of the hallux (HP:0010051)1.45951384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.91395005
2MAP3K93.27570631
3NTRK33.27446669
4EPHA42.42330351
5PRKD32.41691189
6MST1R2.31298678
7MAP3K42.25000098
8PAK62.13718764
9STK382.12824236
10TYRO32.11262235
11MET2.10431642
12AKT32.03080208
13DAPK22.02548270
14MINK12.00477888
15CDK121.98896464
16TTN1.97789289
17TRIB31.94244481
18ICK1.93032329
19PNCK1.91922118
20CAMKK11.82977999
21CAMKK21.76918667
22MYLK1.74572518
23CASK1.68383020
24KSR21.65777693
25MARK11.65246329
26NTRK21.64618928
27NTRK11.64441389
28PAK21.63181627
29PRPF4B1.55203015
30MAP3K21.42203179
31EPHA21.41950836
32ARAF1.41869841
33WNK11.39762376
34NEK11.37790013
35UHMK11.36638865
36ALK1.36515460
37GRK51.34605258
38EEF2K1.28739310
39LIMK11.23100383
40CDC42BPA1.14946488
41PIM21.09992085
42KSR11.09951116
43CDK51.07369782
44BRD41.06974151
45CAMK2B1.06739560
46DAPK11.06516583
47PDGFRA1.06090835
48MAP2K71.06042707
49SIK11.03377292
50TAOK11.02621370
51LATS11.02584745
52EPHB20.99738908
53SGK20.99287726
54PINK10.98892219
55ERBB40.98117160
56SGK4940.94943386
57SGK2230.94943386
58HIPK20.94414447
59MAP2K40.93908621
60LATS20.93555197
61LMTK20.91155292
62STK110.88178024
63SIK20.87700285
64DMPK0.87172857
65CAMK2G0.85308489
66CAMK40.85098011
67PHKG10.83837175
68PHKG20.83837175
69SCYL20.83527142
70PRKCG0.82969707
71SGK30.82838806
72CAMK1D0.81946704
73SMG10.80223126
74DYRK1A0.79958352
75DDR20.78846882
76CDK150.78253205
77CAMK1G0.77884558
78CDK180.75873944
79PRKD20.75649993
80BRAF0.74734039
81PTK20.73613316
82CDK140.70735977
83CAMK10.70383881
84ROCK10.68453409
85PRKCH0.68380603
86CDK11A0.68088748
87ROCK20.67003350
88PDGFRB0.66114504
89TESK10.65242019
90MARK20.65091001
91RET0.64129529
92MAPK100.61640535
93BRSK10.61319227
94FER0.61264185
95RPS6KA30.60379267
96CSNK1E0.59401605
97BMX0.58858618
98DAPK30.58756676
99MAPK130.58640063
100CAMK2D0.57478179
101GSK3B0.56920186
102WNK30.55699594
103SGK10.55316076
104PLK30.54604477
105RPS6KA20.52175139
106RAF10.50686045
107PLK20.48410336
108MAP3K60.48399570
109PRKCI0.48255712
110NEK20.47873805
111GRK10.47772975
112ERBB20.47752034
113MAP3K100.46330166
114CDK20.45369049
115MAPK140.44651166
116TAOK20.44517951
117CHEK10.44228518
118PRKDC0.43420796
119FGFR10.43200024
120MAP2K10.43101508
121MTOR0.42530012
122MAPK80.42390410
123TNIK0.42305592
124MOS0.41086830
125FGFR20.40932910
126CSNK1D0.40595613
127CDK10.40135450
128CDC70.39919167
129AURKA0.39876402
130MAP3K10.38874693
131CAMK2A0.38592937
132MELK0.38428812
133PAK40.37485917
134CDK80.37346707
135PAK30.37247954

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.05587971
2Phototransduction_Homo sapiens_hsa047442.82527768
3Synaptic vesicle cycle_Homo sapiens_hsa047212.80963474
4Olfactory transduction_Homo sapiens_hsa047402.62624754
5GABAergic synapse_Homo sapiens_hsa047272.58576297
6Circadian entrainment_Homo sapiens_hsa047132.52188981
7Glutamatergic synapse_Homo sapiens_hsa047242.43571823
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38335509
9Morphine addiction_Homo sapiens_hsa050322.32129416
10Long-term potentiation_Homo sapiens_hsa047202.31904820
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20294986
12Insulin secretion_Homo sapiens_hsa049112.18739423
13Dopaminergic synapse_Homo sapiens_hsa047282.00703286
14ECM-receptor interaction_Homo sapiens_hsa045121.95356158
15Amphetamine addiction_Homo sapiens_hsa050311.92851787
16Taste transduction_Homo sapiens_hsa047421.91711377
17Salivary secretion_Homo sapiens_hsa049701.82667261
18Cholinergic synapse_Homo sapiens_hsa047251.80337134
19Long-term depression_Homo sapiens_hsa047301.70473155
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66797643
21Focal adhesion_Homo sapiens_hsa045101.60232227
22Vitamin B6 metabolism_Homo sapiens_hsa007501.57511621
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51888806
24Gastric acid secretion_Homo sapiens_hsa049711.51393220
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44152360
26Type II diabetes mellitus_Homo sapiens_hsa049301.42153843
27Serotonergic synapse_Homo sapiens_hsa047261.41966685
28Oxytocin signaling pathway_Homo sapiens_hsa049211.41456289
29Gap junction_Homo sapiens_hsa045401.40059376
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38249623
31Renin secretion_Homo sapiens_hsa049241.36961298
32Cocaine addiction_Homo sapiens_hsa050301.33344859
33GnRH signaling pathway_Homo sapiens_hsa049121.27197954
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22623674
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21548563
36Calcium signaling pathway_Homo sapiens_hsa040201.20654475
37Oocyte meiosis_Homo sapiens_hsa041141.18558234
38cAMP signaling pathway_Homo sapiens_hsa040241.17858735
39Estrogen signaling pathway_Homo sapiens_hsa049151.16749759
40mTOR signaling pathway_Homo sapiens_hsa041501.15552114
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15053547
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14263704
43MicroRNAs in cancer_Homo sapiens_hsa052061.11535924
44Melanogenesis_Homo sapiens_hsa049161.05661775
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05249981
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04390300
47Alcoholism_Homo sapiens_hsa050341.03587099
48Pancreatic secretion_Homo sapiens_hsa049720.95066661
49Hedgehog signaling pathway_Homo sapiens_hsa043400.94614096
50Thyroid hormone synthesis_Homo sapiens_hsa049180.94161554
51Endometrial cancer_Homo sapiens_hsa052130.93183225
52Protein digestion and absorption_Homo sapiens_hsa049740.93007662
53Glioma_Homo sapiens_hsa052140.92391164
54Hippo signaling pathway_Homo sapiens_hsa043900.91911024
55TGF-beta signaling pathway_Homo sapiens_hsa043500.91528374
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90328989
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90117759
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.89995496
59ErbB signaling pathway_Homo sapiens_hsa040120.87877223
60Inositol phosphate metabolism_Homo sapiens_hsa005620.87626736
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87368015
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87238457
63Tight junction_Homo sapiens_hsa045300.86692936
64Dorso-ventral axis formation_Homo sapiens_hsa043200.86278462
65Circadian rhythm_Homo sapiens_hsa047100.85921042
66Basal cell carcinoma_Homo sapiens_hsa052170.82213302
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.81694154
68Wnt signaling pathway_Homo sapiens_hsa043100.81168875
69Axon guidance_Homo sapiens_hsa043600.80983528
70Lysine degradation_Homo sapiens_hsa003100.80474346
71Dilated cardiomyopathy_Homo sapiens_hsa054140.79352653
72Chronic myeloid leukemia_Homo sapiens_hsa052200.78536493
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78333322
74mRNA surveillance pathway_Homo sapiens_hsa030150.77613488
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75172891
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74967489
77Small cell lung cancer_Homo sapiens_hsa052220.74726949
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70129200
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.69246401
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69039271
81Biosynthesis of amino acids_Homo sapiens_hsa012300.68146730
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68058552
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.67855422
84MAPK signaling pathway_Homo sapiens_hsa040100.67143709
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65953537
86Colorectal cancer_Homo sapiens_hsa052100.65204383
87Prion diseases_Homo sapiens_hsa050200.64768844
88Rap1 signaling pathway_Homo sapiens_hsa040150.64590130
89Cell cycle_Homo sapiens_hsa041100.63759822
90Choline metabolism in cancer_Homo sapiens_hsa052310.62957822
91AMPK signaling pathway_Homo sapiens_hsa041520.62214754
92Amoebiasis_Homo sapiens_hsa051460.61963876
93Pathways in cancer_Homo sapiens_hsa052000.61060201
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.61035736
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60655090
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60214536
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59802234
98Cardiac muscle contraction_Homo sapiens_hsa042600.59453309
99Glucagon signaling pathway_Homo sapiens_hsa049220.58941905
100VEGF signaling pathway_Homo sapiens_hsa043700.57855237
101Bile secretion_Homo sapiens_hsa049760.57716625
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57669395
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57406673
104Collecting duct acid secretion_Homo sapiens_hsa049660.57230677
105Non-small cell lung cancer_Homo sapiens_hsa052230.54749222
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53386414
107Ras signaling pathway_Homo sapiens_hsa040140.53025726
108Vibrio cholerae infection_Homo sapiens_hsa051100.52349590
109Thyroid cancer_Homo sapiens_hsa052160.50101138
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49050420
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47969652
112Notch signaling pathway_Homo sapiens_hsa043300.46765832
113Insulin signaling pathway_Homo sapiens_hsa049100.45555541
114Renal cell carcinoma_Homo sapiens_hsa052110.44119644
115Adherens junction_Homo sapiens_hsa045200.44113671
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41851150
117Melanoma_Homo sapiens_hsa052180.41419453
118Mineral absorption_Homo sapiens_hsa049780.40834214
119Endocytosis_Homo sapiens_hsa041440.39820527
120Proteoglycans in cancer_Homo sapiens_hsa052050.39226295
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38476774
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37678592
123Bladder cancer_Homo sapiens_hsa052190.35224062

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