MTBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.44877755
2nuclear pore organization (GO:0006999)5.35041597
3DNA unwinding involved in DNA replication (GO:0006268)5.24219503
4* protein localization to kinetochore (GO:0034501)5.17531140
5mitotic sister chromatid cohesion (GO:0007064)4.57235126
6mitotic chromosome condensation (GO:0007076)4.55930595
7DNA replication initiation (GO:0006270)4.43352924
8mitotic nuclear envelope disassembly (GO:0007077)4.43251644
9* protein localization to chromosome, centromeric region (GO:0071459)4.38910735
10DNA strand elongation involved in DNA replication (GO:0006271)4.37630809
11replication fork processing (GO:0031297)4.33032210
12sister chromatid segregation (GO:0000819)4.24606578
13DNA strand elongation (GO:0022616)4.20192641
14mitotic sister chromatid segregation (GO:0000070)4.18793082
15regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.18109110
16regulation of mitotic spindle checkpoint (GO:1903504)4.18109110
17DNA replication-dependent nucleosome assembly (GO:0006335)4.15734672
18DNA replication-dependent nucleosome organization (GO:0034723)4.15734672
19pore complex assembly (GO:0046931)4.14741105
20membrane disassembly (GO:0030397)4.13590197
21nuclear envelope disassembly (GO:0051081)4.13590197
22mitotic metaphase plate congression (GO:0007080)4.03433120
23DNA double-strand break processing (GO:0000729)4.01903823
24chromatin remodeling at centromere (GO:0031055)3.94109532
25CENP-A containing nucleosome assembly (GO:0034080)3.90681741
26kinetochore organization (GO:0051383)3.90564157
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90510515
28DNA replication checkpoint (GO:0000076)3.90455191
29folic acid-containing compound biosynthetic process (GO:0009396)3.88670580
30telomere maintenance via semi-conservative replication (GO:0032201)3.87202719
31mitotic recombination (GO:0006312)3.82716156
32DNA duplex unwinding (GO:0032508)3.80670597
33regulation of RNA export from nucleus (GO:0046831)3.79087810
34DNA geometric change (GO:0032392)3.79013471
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.78674588
36telomere maintenance via recombination (GO:0000722)3.69855295
37DNA replication-independent nucleosome assembly (GO:0006336)3.68115817
38DNA replication-independent nucleosome organization (GO:0034724)3.68115817
39attachment of spindle microtubules to kinetochore (GO:0008608)3.66598946
40regulation of centriole replication (GO:0046599)3.66259386
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65454272
42regulation of spindle organization (GO:0090224)3.64602127
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.62264656
44regulation of sister chromatid cohesion (GO:0007063)3.61470168
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59999193
46metaphase plate congression (GO:0051310)3.54902424
47positive regulation of chromosome segregation (GO:0051984)3.54363236
48chromatin assembly (GO:0031497)3.53177268
49translesion synthesis (GO:0019985)3.52906406
50meiotic chromosome segregation (GO:0045132)3.51318295
51histone exchange (GO:0043486)3.50355540
52regulation of centrosome cycle (GO:0046605)3.49208851
53IMP biosynthetic process (GO:0006188)3.48728736
54cullin deneddylation (GO:0010388)3.48345817
55chromatin assembly or disassembly (GO:0006333)3.45961942
56synapsis (GO:0007129)3.45279904
57regulation of histone H3-K9 methylation (GO:0051570)3.42912309
58chromosome condensation (GO:0030261)3.38554415
59recombinational repair (GO:0000725)3.36767799
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.36486289
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.36486289
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.36486289
63DNA conformation change (GO:0071103)3.34148180
64double-strand break repair via homologous recombination (GO:0000724)3.34072213
65resolution of meiotic recombination intermediates (GO:0000712)3.33227464
66regulation of mitotic spindle organization (GO:0060236)3.32872616
67* protein localization to chromosome (GO:0034502)3.30845815
68heterochromatin organization (GO:0070828)3.30243496
69establishment of chromosome localization (GO:0051303)3.29081995
70telomere maintenance via telomere lengthening (GO:0010833)3.28033201
71formation of translation preinitiation complex (GO:0001731)3.27689429
72protein K6-linked ubiquitination (GO:0085020)3.26994790
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.24222176
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23327932
75nucleobase biosynthetic process (GO:0046112)3.22873354
76DNA topological change (GO:0006265)3.21512451
77regulation of chromosome segregation (GO:0051983)3.20553055
78DNA catabolic process, exonucleolytic (GO:0000738)3.20312009
79nuclear envelope organization (GO:0006998)3.18901619
80protein deneddylation (GO:0000338)3.15617602
81pseudouridine synthesis (GO:0001522)3.14791640
82dosage compensation (GO:0007549)3.13236469
83DNA packaging (GO:0006323)3.11514366
84centriole replication (GO:0007099)3.11303045
85chromosome segregation (GO:0007059)3.10691832
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10666783
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09637891
88postreplication repair (GO:0006301)3.09386088
89IMP metabolic process (GO:0046040)3.07865086
90regulation of centrosome duplication (GO:0010824)3.07127218
91ATP-dependent chromatin remodeling (GO:0043044)3.06558557
92ribosome assembly (GO:0042255)3.06312163
93respiratory chain complex IV assembly (GO:0008535)3.06009908
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05983232
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05983232
96isotype switching (GO:0045190)3.05983232
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02935472
98rRNA catabolic process (GO:0016075)3.02222860
99double-strand break repair via nonhomologous end joining (GO:0006303)3.01865441
100non-recombinational repair (GO:0000726)3.01865441
101telomere maintenance (GO:0000723)3.01233568
102kinetochore assembly (GO:0051382)3.00174837
103proteasome assembly (GO:0043248)2.98330287
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97695784
105telomere organization (GO:0032200)2.97689780
106DNA strand renaturation (GO:0000733)2.97053219
107negative regulation of chromosome segregation (GO:0051985)2.96291973
108negative regulation of histone methylation (GO:0031061)2.95289869
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.95167746
110somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95167746
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.94867880
112DNA ligation (GO:0006266)2.94163013
113maturation of SSU-rRNA (GO:0030490)2.94095119
114regulation of nucleobase-containing compound transport (GO:0032239)2.93984073
115regulation of DNA endoreduplication (GO:0032875)2.91335120
116maturation of 5.8S rRNA (GO:0000460)2.90657349
117* spindle checkpoint (GO:0031577)2.89936429
118microtubule depolymerization (GO:0007019)2.89173793
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.87752328
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87752328
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87752328
122negative regulation of sister chromatid segregation (GO:0033046)2.87752328
123mitochondrial RNA metabolic process (GO:0000959)2.87254892
124pre-miRNA processing (GO:0031054)2.85574146
125spindle assembly checkpoint (GO:0071173)2.85057879
126regulation of mitotic sister chromatid separation (GO:0010965)2.83865004
127regulation of mitotic sister chromatid segregation (GO:0033047)2.83865004
128regulation of sister chromatid segregation (GO:0033045)2.83865004
129purine nucleobase biosynthetic process (GO:0009113)2.81526042
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81418119
131reciprocal DNA recombination (GO:0035825)2.81022745
132reciprocal meiotic recombination (GO:0007131)2.81022745
133mismatch repair (GO:0006298)2.79284670
134somatic diversification of immunoglobulins (GO:0016445)2.79255799
135termination of RNA polymerase III transcription (GO:0006386)2.77549222
136transcription elongation from RNA polymerase III promoter (GO:0006385)2.77549222
137mitochondrial respiratory chain complex assembly (GO:0033108)2.74894078
138somatic recombination of immunoglobulin gene segments (GO:0016447)2.74110387
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70742739
140mitochondrial respiratory chain complex I assembly (GO:0032981)2.70742739
141NADH dehydrogenase complex assembly (GO:0010257)2.70742739
142protein complex biogenesis (GO:0070271)2.70622192
143DNA-dependent DNA replication (GO:0006261)2.70241642
144DNA recombination (GO:0006310)2.68951780
145double-strand break repair (GO:0006302)2.68937925
146negative regulation of DNA recombination (GO:0045910)2.68745745
147protein-cofactor linkage (GO:0018065)2.68119867
148protein prenylation (GO:0018342)2.66600971
149prenylation (GO:0097354)2.66600971
150DNA deamination (GO:0045006)2.66296574
151* mitotic spindle checkpoint (GO:0071174)2.65512178
152water-soluble vitamin biosynthetic process (GO:0042364)2.64455737
153cytochrome complex assembly (GO:0017004)2.63332398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.55127575
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.35370349
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67832103
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.59470573
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.35609904
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83079622
7ZNF274_21170338_ChIP-Seq_K562_Hela2.82960667
8AR_21909140_ChIP-Seq_LNCAP_Human2.80987592
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74519777
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55160778
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.47647855
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42508013
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41480285
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40479883
15VDR_22108803_ChIP-Seq_LS180_Human2.39428029
16EWS_26573619_Chip-Seq_HEK293_Human2.37660349
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25583980
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19228510
19FUS_26573619_Chip-Seq_HEK293_Human2.11984069
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07123407
21IGF1R_20145208_ChIP-Seq_DFB_Human2.05389196
22E2F7_22180533_ChIP-Seq_HELA_Human11.5425586
23MYC_22102868_ChIP-Seq_BL_Human1.98548683
24XRN2_22483619_ChIP-Seq_HELA_Human1.98165905
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.95096129
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94379153
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.84557499
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83434086
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79948415
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75861147
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.75433074
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72198268
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.71243468
34VDR_23849224_ChIP-Seq_CD4+_Human1.70995273
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67528660
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66550150
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66385183
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65159152
39TAF15_26573619_Chip-Seq_HEK293_Human1.63084729
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.61715892
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56778971
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.54812110
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52639812
44IRF1_19129219_ChIP-ChIP_H3396_Human1.51605204
45GBX2_23144817_ChIP-Seq_PC3_Human1.51420238
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50149445
47ELK1_19687146_ChIP-ChIP_HELA_Human1.49785657
48* GABP_17652178_ChIP-ChIP_JURKAT_Human1.47503767
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.46067426
50TTF2_22483619_ChIP-Seq_HELA_Human1.45957122
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45792872
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45705829
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44871726
54* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43372878
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42068508
56P300_19829295_ChIP-Seq_ESCs_Human1.41343580
57* DCP1A_22483619_ChIP-Seq_HELA_Human1.40781918
58CIITA_25753668_ChIP-Seq_RAJI_Human1.39910588
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39603899
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39346347
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39310480
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38304166
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37753219
64KDM5A_27292631_Chip-Seq_BREAST_Human1.37150406
65* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36398846
66GABP_19822575_ChIP-Seq_HepG2_Human1.36196301
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36005031
68ER_23166858_ChIP-Seq_MCF-7_Human1.34880304
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34225851
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34013106
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33602118
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33533582
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26733482
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25319027
75* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23080235
76* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21586411
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20999016
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20155050
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17987022
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17730117
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15977628
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15604498
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15565617
84TFEB_21752829_ChIP-Seq_HELA_Human1.15218839
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14857793
86VDR_21846776_ChIP-Seq_THP-1_Human1.14847581
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13862014
88TP53_22573176_ChIP-Seq_HFKS_Human1.13491326
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13186929
90* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11199015
91CBP_20019798_ChIP-Seq_JUKART_Human1.09874573
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09874573
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09448348
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09386733
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08475701
96* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08389669
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.06375886
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06090683
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05489398
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03597960
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03424207
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03124197
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01770851
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01347619
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.00892567
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00175928
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99719971
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97788023
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96775397
110SOX2_16153702_ChIP-ChIP_HESCs_Human0.96308490
111* FOXA1_25329375_ChIP-Seq_VCAP_Human0.95253051
112* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95253051
113STAT3_23295773_ChIP-Seq_U87_Human0.95082976
114* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94665466
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.93361982
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92885793
117MYC_18940864_ChIP-ChIP_HL60_Human0.92750601
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92143266
119SMAD4_21799915_ChIP-Seq_A2780_Human0.91257043
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90947807
121MYB_26560356_Chip-Seq_TH1_Human0.90132744
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89964180
123TCF4_22108803_ChIP-Seq_LS180_Human0.89636763
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89627489
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88039171
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87877294
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87517267
128SOX2_19829295_ChIP-Seq_ESCs_Human0.87362275
129NANOG_19829295_ChIP-Seq_ESCs_Human0.87362275
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86983863
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.86907425
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86855427
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85919568
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85705400
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84737781
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82616954
137MYB_26560356_Chip-Seq_TH2_Human0.82005373
138SPI1_23547873_ChIP-Seq_NB4_Human0.81505617
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.81114724
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79156719
141* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78834178
142UTX_26944678_Chip-Seq_JUKART_Human0.78463915
143CHD1_26751641_Chip-Seq_LNCaP_Human0.78331529
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75455788
145MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75267754
146TCF7_22412390_ChIP-Seq_EML_Mouse0.74903933
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74184383
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73222688
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.71509479
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71341456
151* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71293183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.64839547
2MP0010094_abnormal_chromosome_stability4.48082008
3MP0003693_abnormal_embryo_hatching3.86013578
4MP0003111_abnormal_nucleus_morphology3.85203618
5MP0003077_abnormal_cell_cycle3.58323596
6MP0004957_abnormal_blastocyst_morpholog3.49682527
7MP0010352_gastrointestinal_tract_polyps3.24049793
8MP0008007_abnormal_cellular_replicative2.77040801
9MP0006292_abnormal_olfactory_placode2.70402845
10MP0008058_abnormal_DNA_repair2.53316834
11MP0002102_abnormal_ear_morphology2.38841287
12MP0008877_abnormal_DNA_methylation2.31086824
13MP0003123_paternal_imprinting2.29017747
14MP0010307_abnormal_tumor_latency2.27657285
15MP0006072_abnormal_retinal_apoptosis2.24137688
16MP0008932_abnormal_embryonic_tissue2.18529669
17MP0002396_abnormal_hematopoietic_system2.15373527
18MP0001730_embryonic_growth_arrest2.13977152
19MP0000350_abnormal_cell_proliferation2.09126105
20MP0002938_white_spotting1.99988873
21MP0005076_abnormal_cell_differentiation1.97232539
22MP0003705_abnormal_hypodermis_morpholog1.92707734
23MP0003787_abnormal_imprinting1.92295745
24MP0004808_abnormal_hematopoietic_stem1.90643746
25MP0004147_increased_porphyrin_level1.84451637
26MP0005551_abnormal_eye_electrophysiolog1.79806564
27MP0002234_abnormal_pharynx_morphology1.76298360
28MP0000372_irregular_coat_pigmentation1.75423355
29MP0005380_embryogenesis_phenotype1.72906630
30MP0001672_abnormal_embryogenesis/_devel1.72906630
31MP0005253_abnormal_eye_physiology1.72710391
32MP0003136_yellow_coat_color1.69973365
33MP0003786_premature_aging1.68964619
34MP0001697_abnormal_embryo_size1.66861057
35MP0003121_genomic_imprinting1.65063202
36MP0000490_abnormal_crypts_of1.64559376
37MP0004197_abnormal_fetal_growth/weight/1.62149507
38MP0000383_abnormal_hair_follicle1.61698916
39MP0003984_embryonic_growth_retardation1.59922342
40MP0000427_abnormal_hair_cycle1.57108637
41MP0002088_abnormal_embryonic_growth/wei1.56919718
42MP0002084_abnormal_developmental_patter1.54526971
43MP0002085_abnormal_embryonic_tissue1.53135644
44MP0006054_spinal_hemorrhage1.51565004
45MP0002638_abnormal_pupillary_reflex1.48248993
46MP0000569_abnormal_digit_pigmentation1.48022508
47* MP0002080_prenatal_lethality1.46423709
48MP0002086_abnormal_extraembryonic_tissu1.45333012
49MP0000631_abnormal_neuroendocrine_gland1.40063684
50MP0001984_abnormal_olfaction1.39946199
51MP0008789_abnormal_olfactory_epithelium1.38997751
52MP0002837_dystrophic_cardiac_calcinosis1.35229653
53MP0000537_abnormal_urethra_morphology1.32843149
54MP0000313_abnormal_cell_death1.32359754
55MP0003763_abnormal_thymus_physiology1.28434138
56* MP0002019_abnormal_tumor_incidence1.27981732
57MP0003567_abnormal_fetal_cardiomyocyte1.26453714
58MP0010030_abnormal_orbit_morphology1.24731827
59MP0006035_abnormal_mitochondrial_morpho1.24714979
60MP0003880_abnormal_central_pattern1.18630154
61MP0002163_abnormal_gland_morphology1.18432533
62MP0000703_abnormal_thymus_morphology1.18375697
63MP0002095_abnormal_skin_pigmentation1.17758717
64MP0005646_abnormal_pituitary_gland1.17284909
65MP0000733_abnormal_muscle_development1.16759596
66MP0005075_abnormal_melanosome_morpholog1.16745197
67MP0002210_abnormal_sex_determination1.16552224
68MP0001529_abnormal_vocalization1.16332603
69MP0008995_early_reproductive_senescence1.15482168
70MP0009278_abnormal_bone_marrow1.15223319
71MP0003566_abnormal_cell_adhesion1.13879721
72MP0005084_abnormal_gallbladder_morpholo1.13104189
73MP0000647_abnormal_sebaceous_gland1.12992878
74MP0002751_abnormal_autonomic_nervous1.12440087
75MP0002160_abnormal_reproductive_system1.11583837
76MP0005023_abnormal_wound_healing1.10212132
77MP0005391_vision/eye_phenotype1.10204670
78MP0001929_abnormal_gametogenesis1.09426465
79MP0006276_abnormal_autonomic_nervous1.05468499
80MP0003890_abnormal_embryonic-extraembry1.05295957
81MP0001545_abnormal_hematopoietic_system1.05264010
82MP0005397_hematopoietic_system_phenotyp1.05264010
83MP0003195_calcinosis1.05140626
84MP0001145_abnormal_male_reproductive1.05081187
85MP0001286_abnormal_eye_development1.04482926
86MP0002398_abnormal_bone_marrow1.03296944
87MP0001293_anophthalmia1.03275151
88MP0010678_abnormal_skin_adnexa1.02656666
89MP0001915_intracranial_hemorrhage1.01665239
90MP0005389_reproductive_system_phenotype1.00905866
91MP0002009_preneoplasia1.00028536
92MP0009333_abnormal_splenocyte_physiolog0.99339863
93MP0002233_abnormal_nose_morphology0.95743951
94MP0004142_abnormal_muscle_tone0.95117360
95MP0005195_abnormal_posterior_eye0.93093756
96MP0002736_abnormal_nociception_after0.92617006
97MP0004133_heterotaxia0.92555701
98MP0003937_abnormal_limbs/digits/tail_de0.91481059
99MP0009672_abnormal_birth_weight0.91446800
100MP0002722_abnormal_immune_system0.90902302
101MP0001764_abnormal_homeostasis0.90654348
102MP0009046_muscle_twitch0.90416241
103MP0000653_abnormal_sex_gland0.89823245
104MP0009703_decreased_birth_body0.89767473
105MP0001324_abnormal_eye_pigmentation0.89649174
106MP0002166_altered_tumor_susceptibility0.88703791
107MP0008438_abnormal_cutaneous_collagen0.88096145
108MP0009053_abnormal_anal_canal0.87739468
109MP0005499_abnormal_olfactory_system0.87723124
110MP0005394_taste/olfaction_phenotype0.87723124
111MP0002006_tumorigenesis0.87616714
112MP0005174_abnormal_tail_pigmentation0.86989960
113MP0002877_abnormal_melanocyte_morpholog0.86780191
114MP0000689_abnormal_spleen_morphology0.86738380
115MP0005379_endocrine/exocrine_gland_phen0.86639432
116MP0008875_abnormal_xenobiotic_pharmacok0.83954561
117MP0005621_abnormal_cell_physiology0.83796119
118MP0001919_abnormal_reproductive_system0.82759416
119MP0002928_abnormal_bile_duct0.82349146
120MP0005171_absent_coat_pigmentation0.81874440
121MP0005623_abnormal_meninges_morphology0.81689656
122MP0002111_abnormal_tail_morphology0.81475045
123MP0005645_abnormal_hypothalamus_physiol0.80738164
124MP0008872_abnormal_physiological_respon0.80659486
125MP0000432_abnormal_head_morphology0.80559190
126MP0006036_abnormal_mitochondrial_physio0.79438013
127MP0009697_abnormal_copulation0.77490470
128MP0002925_abnormal_cardiovascular_devel0.77457725
129MP0002282_abnormal_trachea_morphology0.76975993
130MP0005384_cellular_phenotype0.76965277
131MP0002092_abnormal_eye_morphology0.76628699
132MP0000428_abnormal_craniofacial_morphol0.76218147
133MP0002429_abnormal_blood_cell0.72758049
134MP0001873_stomach_inflammation0.72259132
135MP0001119_abnormal_female_reproductive0.69839587
136MP0003115_abnormal_respiratory_system0.69328055
137MP0002752_abnormal_somatic_nervous0.68897669
138MP0003448_altered_tumor_morphology0.68062120
139MP0002697_abnormal_eye_size0.67735539
140MP0003806_abnormal_nucleotide_metabolis0.67619806
141MP0003646_muscle_fatigue0.67299255
142MP0001986_abnormal_taste_sensitivity0.67233929
143MP0001968_abnormal_touch/_nociception0.67202998
144MP0005395_other_phenotype0.67178654
145MP0003718_maternal_effect0.66857086
146MP0003011_delayed_dark_adaptation0.66599979
147MP0003935_abnormal_craniofacial_develop0.66453756
148MP0000371_diluted_coat_color0.65129513
149MP0000477_abnormal_intestine_morphology0.64326327
150MP0000716_abnormal_immune_system0.61614857
151MP0002405_respiratory_system_inflammati0.61410626
152MP0003943_abnormal_hepatobiliary_system0.61292489
153* MP0000858_altered_metastatic_potential0.61227795
154MP0002932_abnormal_joint_morphology0.61222073
155MP0003698_abnormal_male_reproductive0.58744308
156MP0000358_abnormal_cell_content/0.58624325
157MP0001849_ear_inflammation0.58482560
158MP0003119_abnormal_digestive_system0.58452723
159MP0002114_abnormal_axial_skeleton0.57769674
160MP0004233_abnormal_muscle_weight0.57463420
161MP0002075_abnormal_coat/hair_pigmentati0.56229342
162MP0003755_abnormal_palate_morphology0.55746776

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.18649310
2Selective tooth agenesis (HP:0001592)4.05498565
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84194732
4Pancreatic cysts (HP:0001737)3.69467487
5Volvulus (HP:0002580)3.58323091
6Birth length less than 3rd percentile (HP:0003561)3.49228166
7Pancreatic fibrosis (HP:0100732)3.40075311
8Abnormality of chromosome stability (HP:0003220)3.30447239
911 pairs of ribs (HP:0000878)3.29008220
10Molar tooth sign on MRI (HP:0002419)3.17947129
11Abnormality of midbrain morphology (HP:0002418)3.17947129
12Increased nuchal translucency (HP:0010880)3.14721957
13True hermaphroditism (HP:0010459)3.13032693
14Reticulocytopenia (HP:0001896)2.97865862
15Ectopic kidney (HP:0000086)2.90491922
16Deviation of the thumb (HP:0009603)2.84002463
17Nephronophthisis (HP:0000090)2.81233173
18Ependymoma (HP:0002888)2.79216277
19Proximal placement of thumb (HP:0009623)2.75836987
20Meckel diverticulum (HP:0002245)2.71726446
21Abnormality of the renal cortex (HP:0011035)2.60185938
22Abnormality of the ileum (HP:0001549)2.59260216
23Medial flaring of the eyebrow (HP:0010747)2.59209649
24Missing ribs (HP:0000921)2.59091457
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.58510027
26Medulloblastoma (HP:0002885)2.57339253
27Short 4th metacarpal (HP:0010044)2.57094645
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57094645
29Abnormality of the preputium (HP:0100587)2.48590657
30Myelodysplasia (HP:0002863)2.45412861
31Congenital stationary night blindness (HP:0007642)2.44244351
32Clubbing of toes (HP:0100760)2.43357575
33Abnormality of the renal medulla (HP:0100957)2.42337819
34Colon cancer (HP:0003003)2.41920819
35Oligodactyly (hands) (HP:0001180)2.41228504
36Increased CSF lactate (HP:0002490)2.38591025
37Duodenal stenosis (HP:0100867)2.37701301
38Small intestinal stenosis (HP:0012848)2.37701301
39Renal cortical cysts (HP:0000803)2.36931661
40Patellar aplasia (HP:0006443)2.35457988
41Cutaneous melanoma (HP:0012056)2.33905544
42Sloping forehead (HP:0000340)2.33667840
43Acute necrotizing encephalopathy (HP:0006965)2.31335719
44Increased hepatocellular lipid droplets (HP:0006565)2.29429878
45Lipid accumulation in hepatocytes (HP:0006561)2.28622369
46Impulsivity (HP:0100710)2.26341855
47Breast hypoplasia (HP:0003187)2.23721520
48Rhabdomyosarcoma (HP:0002859)2.20589213
49High pitched voice (HP:0001620)2.20218767
50Congenital primary aphakia (HP:0007707)2.19730704
51Aplasia/Hypoplasia of the patella (HP:0006498)2.16714290
52Acute encephalopathy (HP:0006846)2.15941904
53Abnormality of the pons (HP:0007361)2.15627159
54Abnormality of the astrocytes (HP:0100707)2.15183662
55Astrocytoma (HP:0009592)2.15183662
56Nephroblastoma (Wilms tumor) (HP:0002667)2.14674098
57Atresia of the external auditory canal (HP:0000413)2.14526308
58Type II lissencephaly (HP:0007260)2.14377302
59Mitochondrial inheritance (HP:0001427)2.13867231
60Agnosia (HP:0010524)2.12615973
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.12338097
62Hypoplasia of the pons (HP:0012110)2.11916501
63Syringomyelia (HP:0003396)2.11803444
64Spinal cord lesions (HP:0100561)2.11803444
65Absent radius (HP:0003974)2.11386848
66Cystic liver disease (HP:0006706)2.10946957
67Abnormality of the carotid arteries (HP:0005344)2.10578029
68Prominent nose (HP:0000448)2.10385496
69Gait imbalance (HP:0002141)2.09776809
70Sclerocornea (HP:0000647)2.08748119
71Abnormality of the labia minora (HP:0012880)2.07062409
72Postaxial foot polydactyly (HP:0001830)2.04953612
73Degeneration of anterior horn cells (HP:0002398)2.04765569
74Abnormality of the anterior horn cell (HP:0006802)2.04765569
75Chronic hepatic failure (HP:0100626)2.04128080
76Duplicated collecting system (HP:0000081)2.04054010
77Increased density of long bones (HP:0006392)2.03346518
78Triphalangeal thumb (HP:0001199)2.02884305
79Nephrogenic diabetes insipidus (HP:0009806)2.01873828
80Abnormality of the calcaneus (HP:0008364)2.01853064
81Embryonal renal neoplasm (HP:0011794)2.01414501
82Progressive macrocephaly (HP:0004481)2.01118195
83Long eyelashes (HP:0000527)2.00535408
84Abnormality of the fingertips (HP:0001211)2.00494949
85Absent thumb (HP:0009777)2.00360918
86Basal cell carcinoma (HP:0002671)1.99469571
87Abnormal mitochondria in muscle tissue (HP:0008316)1.98305684
88Cafe-au-lait spot (HP:0000957)1.97862880
89Pendular nystagmus (HP:0012043)1.97512729
90Preaxial hand polydactyly (HP:0001177)1.97485998
91Abnormality of the duodenum (HP:0002246)1.97369797
92Increased serum lactate (HP:0002151)1.96909584
93Aplasia involving forearm bones (HP:0009822)1.95802786
94Absent forearm bone (HP:0003953)1.95802786
95Astigmatism (HP:0000483)1.94458658
96Attenuation of retinal blood vessels (HP:0007843)1.93292319
97Cerebellar dysplasia (HP:0007033)1.93004816
98Abnormality of the renal collecting system (HP:0004742)1.92622581
99Congenital, generalized hypertrichosis (HP:0004540)1.92412934
100Tubulointerstitial nephritis (HP:0001970)1.92322016
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.92062285
102Abnormality of abdominal situs (HP:0011620)1.91953437
103Abdominal situs inversus (HP:0003363)1.91953437
104Abnormality of alanine metabolism (HP:0010916)1.91578135
105Hyperalaninemia (HP:0003348)1.91578135
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91578135
107Acute myeloid leukemia (HP:0004808)1.89310847
108Progressive inability to walk (HP:0002505)1.88775775
109Dislocated radial head (HP:0003083)1.88519294
110Deep philtrum (HP:0002002)1.87749471
111Genital tract atresia (HP:0001827)1.86944142
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.86216387
113Metaphyseal cupping (HP:0003021)1.86175835
114Ankle contracture (HP:0006466)1.85956861
115Gastrointestinal carcinoma (HP:0002672)1.85799210
116Malignant gastrointestinal tract tumors (HP:0006749)1.85799210
117Abnormal number of incisors (HP:0011064)1.85638489
118Subacute progressive viral hepatitis (HP:0006572)1.85511536
119Neoplasm of the pancreas (HP:0002894)1.84793042
120Heterotopia (HP:0002282)1.84645327
121Absent frontal sinuses (HP:0002688)1.84603431
122Tubular atrophy (HP:0000092)1.83626909
123Broad palm (HP:0001169)1.82507243
124Hepatocellular necrosis (HP:0001404)1.82476841
125Supernumerary spleens (HP:0009799)1.81490356
126Abnormal number of erythroid precursors (HP:0012131)1.81025413
127Sandal gap (HP:0001852)1.80957671
128Glioma (HP:0009733)1.80031136
129Abnormality of DNA repair (HP:0003254)1.79887278
130Vaginal atresia (HP:0000148)1.79738764
131Hepatic necrosis (HP:0002605)1.79710230
132Thrombocytosis (HP:0001894)1.79172567
133Squamous cell carcinoma (HP:0002860)1.78563914
134Neoplasm of the oral cavity (HP:0100649)1.78524923
135Methylmalonic acidemia (HP:0002912)1.77743071
136Protrusio acetabuli (HP:0003179)1.77251616
137Dandy-Walker malformation (HP:0001305)1.76133360
138Neoplasm of striated muscle (HP:0009728)1.76094545
139Lissencephaly (HP:0001339)1.75295970
140Intestinal atresia (HP:0011100)1.74985938
141Abnormal lung lobation (HP:0002101)1.74651878
142Hypoplastic pelvis (HP:0008839)1.74192696
143Short thumb (HP:0009778)1.74095362
144Anencephaly (HP:0002323)1.73903849
145Abnormality of the radial head (HP:0003995)1.73377204
146Facial hemangioma (HP:0000329)1.73215092
147Abnormality of the 4th metacarpal (HP:0010012)1.73192640
148Bone marrow hypocellularity (HP:0005528)1.73133110
149Shallow orbits (HP:0000586)1.72501739
150Small hand (HP:0200055)1.72441104
151Overlapping toe (HP:0001845)1.70662341
152Abnormal rod and cone electroretinograms (HP:0008323)1.70556672
153Constricted visual fields (HP:0001133)1.70198293
154Hyperacusis (HP:0010780)1.70044438
155Bifid tongue (HP:0010297)1.69937041
156Postaxial hand polydactyly (HP:0001162)1.69579025
157Oligodactyly (HP:0012165)1.69445023
158Breast carcinoma (HP:0003002)1.68908035
159Oligohydramnios (HP:0001562)1.67797232
160Carpal bone hypoplasia (HP:0001498)1.67206052
161Large for gestational age (HP:0001520)1.67088749
162Tracheoesophageal fistula (HP:0002575)1.67079924
163Truncal obesity (HP:0001956)1.66321396
164Cutis marmorata (HP:0000965)1.66049569
165Fibular hypoplasia (HP:0003038)1.65924271
166Biliary tract neoplasm (HP:0100574)1.65427510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.91032622
2WEE13.70455277
3FRK3.20497752
4NEK23.13726149
5CDK122.92794608
6BMPR1B2.72335434
7EEF2K2.58007735
8WNK32.57712723
9TTK2.56796563
10BUB12.50443828
11MAP4K22.49413120
12NUAK12.38009489
13STK102.25489196
14ATR2.18717526
15PLK42.06712526
16BRSK22.06625428
17SRPK12.00718313
18TRIM281.97377831
19MKNK11.87137404
20NEK11.86460886
21PLK11.82587383
22ACVR1B1.81598592
23TXK1.79866746
24RPS6KA41.79765578
25MAP3K101.77149402
26AURKB1.75275399
27VRK21.74492047
28PASK1.69053607
29CDK71.67575380
30CDK41.63940608
31STK161.61985835
32RPS6KB21.57967814
33MAP3K81.56080156
34TSSK61.53236910
35CHEK11.48562140
36MST41.46212644
37PLK31.45932059
38STK31.44879829
39CHEK21.43040802
40PKN21.42533405
41ADRBK21.42126789
42MAP3K41.38839243
43PBK1.38574430
44DYRK31.38026773
45EIF2AK11.35786081
46PNCK1.31441824
47LATS11.30991117
48BRD41.29997600
49PDK21.26920244
50CDK61.25644093
51MKNK21.21918535
52VRK11.19885471
53NME11.18940457
54ATM1.18762193
55EPHA21.17895577
56TTN1.17070700
57PIM11.15639884
58STK41.15378179
59NME21.15046110
60WNK41.14554594
61TESK21.13846038
62TAOK31.10133286
63SCYL21.09548742
64PAK41.09526305
65TLK11.07297879
66MAP4K11.06240306
67TNIK1.05359096
68TGFBR11.04065238
69ZAK1.02771294
70ERBB31.02325362
71BRSK11.00592675
72TAF11.00241624
73LRRK20.96669859
74CDK20.95925575
75GRK10.94575441
76MAP2K70.93286952
77ALK0.91185195
78MAPK130.90818779
79INSRR0.90508666
80PTK60.89876242
81CASK0.87668696
82STK390.87015133
83PLK20.86586748
84MELK0.86119862
85TESK10.81601301
86AURKA0.80436620
87PDK30.78015303
88PDK40.78015303
89MTOR0.76191202
90JAK30.73865885
91CDK10.73801649
92TRIB30.69596815
93PAK20.69579879
94BCR0.69386890
95OXSR10.69123652
96STK38L0.69107788
97BCKDK0.66387036
98MARK30.66172249
99CSNK1G10.63521201
100EIF2AK30.62313797
101GRK70.59494333
102PINK10.59372264
103CLK10.56679683
104FLT30.56489454
105BMX0.54323725
106CSNK1G30.53899610
107CCNB10.53171045
108NEK90.52902535
109PAK10.51786749
110DYRK20.51508169
111CHUK0.51159715
112TEC0.49527294
113RPS6KA50.49245353
114PRKDC0.47715638
115CSNK1G20.47418536
116CSF1R0.47309672
117CSNK2A20.46425384
118CSNK1D0.46254856
119PRKCG0.44076853
120PRKCI0.43907598
121ADRBK10.42927043
122TRPM70.41084129
123CSNK2A10.40965688
124MAPK140.40819808
125PRKCE0.40073191
126FGFR10.39322900
127CDK30.38912408
128ERBB40.37546565
129LATS20.36561460
130EIF2AK20.34258154
131AKT10.34114529
132CSNK1A1L0.33979859
133TYK20.33513854
134RPS6KB10.33328711
135MAPK10.32372702
136MAP3K50.30119410
137CDK80.29988689
138CDK90.29302782
139DDR20.29239174
140PDGFRA0.28355068
141MAPKAPK30.27928068
142CSNK1E0.26235042
143ZAP700.26176214
144PAK30.26006668
145ILK0.25679749
146MAPK110.24892952
147MAPKAPK50.24666773
148PRKACB0.24533665
149PKN10.21129951
150IGF1R0.18351674

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.78332095
2Mismatch repair_Homo sapiens_hsa034303.89431829
3Cell cycle_Homo sapiens_hsa041103.27428177
4RNA transport_Homo sapiens_hsa030133.08347878
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02611602
6Homologous recombination_Homo sapiens_hsa034402.92744499
7One carbon pool by folate_Homo sapiens_hsa006702.92038017
8Base excision repair_Homo sapiens_hsa034102.90222404
9Spliceosome_Homo sapiens_hsa030402.84817258
10Non-homologous end-joining_Homo sapiens_hsa034502.80784670
11Fanconi anemia pathway_Homo sapiens_hsa034602.65316150
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62636146
13Protein export_Homo sapiens_hsa030602.55133961
14Nucleotide excision repair_Homo sapiens_hsa034202.46149406
15RNA polymerase_Homo sapiens_hsa030202.04596132
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95760785
17Oxidative phosphorylation_Homo sapiens_hsa001901.91486491
18p53 signaling pathway_Homo sapiens_hsa041151.91111456
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89884293
20RNA degradation_Homo sapiens_hsa030181.87087723
21mRNA surveillance pathway_Homo sapiens_hsa030151.86231306
22Phototransduction_Homo sapiens_hsa047441.74296838
23Pyrimidine metabolism_Homo sapiens_hsa002401.71300357
24Propanoate metabolism_Homo sapiens_hsa006401.71255568
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69404219
26Ribosome_Homo sapiens_hsa030101.67130873
27Systemic lupus erythematosus_Homo sapiens_hsa053221.66620063
28Parkinsons disease_Homo sapiens_hsa050121.65327731
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64411897
30Basal transcription factors_Homo sapiens_hsa030221.59463060
31Viral carcinogenesis_Homo sapiens_hsa052031.54640356
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51204765
33Butanoate metabolism_Homo sapiens_hsa006501.48418193
34Huntingtons disease_Homo sapiens_hsa050161.30981027
35Nitrogen metabolism_Homo sapiens_hsa009101.30709042
36Selenocompound metabolism_Homo sapiens_hsa004501.27495829
37MicroRNAs in cancer_Homo sapiens_hsa052061.26002358
38Small cell lung cancer_Homo sapiens_hsa052221.25477063
39Epstein-Barr virus infection_Homo sapiens_hsa051691.23180758
40Antigen processing and presentation_Homo sapiens_hsa046121.19766697
41Proteasome_Homo sapiens_hsa030501.19461220
42Herpes simplex infection_Homo sapiens_hsa051681.17352984
43HTLV-I infection_Homo sapiens_hsa051661.14636548
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08099128
45Steroid biosynthesis_Homo sapiens_hsa001001.07800423
46Oocyte meiosis_Homo sapiens_hsa041141.06397786
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04463603
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01000140
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.00069504
50Chronic myeloid leukemia_Homo sapiens_hsa052200.95477034
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94315688
52Linoleic acid metabolism_Homo sapiens_hsa005910.90800306
53Alzheimers disease_Homo sapiens_hsa050100.86575366
54Tryptophan metabolism_Homo sapiens_hsa003800.86423579
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84398768
56Hepatitis B_Homo sapiens_hsa051610.82830670
57Peroxisome_Homo sapiens_hsa041460.81763601
58Purine metabolism_Homo sapiens_hsa002300.81215326
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80228392
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77441435
61Folate biosynthesis_Homo sapiens_hsa007900.76794603
62Measles_Homo sapiens_hsa051620.76703937
63Pyruvate metabolism_Homo sapiens_hsa006200.76400137
64Primary immunodeficiency_Homo sapiens_hsa053400.76265797
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75987272
66Lysine degradation_Homo sapiens_hsa003100.75235412
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.75133245
68Colorectal cancer_Homo sapiens_hsa052100.74767662
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74724570
70TGF-beta signaling pathway_Homo sapiens_hsa043500.73703997
71Thyroid cancer_Homo sapiens_hsa052160.70340007
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70258376
73Viral myocarditis_Homo sapiens_hsa054160.69660156
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69450861
75Biosynthesis of amino acids_Homo sapiens_hsa012300.69364194
76Caffeine metabolism_Homo sapiens_hsa002320.68845180
77Apoptosis_Homo sapiens_hsa042100.68605692
78Olfactory transduction_Homo sapiens_hsa047400.67819829
79Fatty acid elongation_Homo sapiens_hsa000620.67747625
80Ether lipid metabolism_Homo sapiens_hsa005650.67701200
81Legionellosis_Homo sapiens_hsa051340.67334998
82Hippo signaling pathway_Homo sapiens_hsa043900.65691155
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65394915
84Metabolic pathways_Homo sapiens_hsa011000.65198475
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64914354
86Adherens junction_Homo sapiens_hsa045200.64462156
87Pentose phosphate pathway_Homo sapiens_hsa000300.64121619
88Sulfur metabolism_Homo sapiens_hsa009200.63799975
89Pancreatic cancer_Homo sapiens_hsa052120.63751232
90Hedgehog signaling pathway_Homo sapiens_hsa043400.62902680
91Shigellosis_Homo sapiens_hsa051310.62057189
92Alcoholism_Homo sapiens_hsa050340.62049407
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61987001
94Nicotine addiction_Homo sapiens_hsa050330.61820232
95Prostate cancer_Homo sapiens_hsa052150.58136590
96Bladder cancer_Homo sapiens_hsa052190.57192681
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.56636608
98mTOR signaling pathway_Homo sapiens_hsa041500.55196431
99Proteoglycans in cancer_Homo sapiens_hsa052050.55125571
100Fatty acid metabolism_Homo sapiens_hsa012120.54867232
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54598565
102Taste transduction_Homo sapiens_hsa047420.54192879
103Basal cell carcinoma_Homo sapiens_hsa052170.52190278
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.51207464
105Acute myeloid leukemia_Homo sapiens_hsa052210.50832448
106Non-small cell lung cancer_Homo sapiens_hsa052230.48204193
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.48063130
108Pathways in cancer_Homo sapiens_hsa052000.47717876
109Influenza A_Homo sapiens_hsa051640.47329483
110Notch signaling pathway_Homo sapiens_hsa043300.47320245
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.47303091
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46631436
113HIF-1 signaling pathway_Homo sapiens_hsa040660.44788328
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44338521
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44072480
116Focal adhesion_Homo sapiens_hsa045100.43893100
117B cell receptor signaling pathway_Homo sapiens_hsa046620.43139006
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42263506
119Regulation of autophagy_Homo sapiens_hsa041400.41985821
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40836100
121ECM-receptor interaction_Homo sapiens_hsa045120.40668716
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.40593640
123Glutathione metabolism_Homo sapiens_hsa004800.40084032
124Toxoplasmosis_Homo sapiens_hsa051450.39423287
125N-Glycan biosynthesis_Homo sapiens_hsa005100.35664392
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35470533
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35338234
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35165877
129Chemical carcinogenesis_Homo sapiens_hsa052040.34923844
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34682987
131Retinol metabolism_Homo sapiens_hsa008300.34228830
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33820672
133Leishmaniasis_Homo sapiens_hsa051400.33781262
134Cardiac muscle contraction_Homo sapiens_hsa042600.32133110
135TNF signaling pathway_Homo sapiens_hsa046680.31869654
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31846430
137Endometrial cancer_Homo sapiens_hsa052130.31641762
138T cell receptor signaling pathway_Homo sapiens_hsa046600.31288548
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.30852464
140Hematopoietic cell lineage_Homo sapiens_hsa046400.30419670
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.29238655
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28529155
143beta-Alanine metabolism_Homo sapiens_hsa004100.28479809
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27670894
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27531202
146FoxO signaling pathway_Homo sapiens_hsa040680.27397489
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27187374
148Fatty acid biosynthesis_Homo sapiens_hsa000610.26797841
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26755952
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26614484
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26378049
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.26373375
153Fatty acid degradation_Homo sapiens_hsa000710.26349926
154Melanoma_Homo sapiens_hsa052180.25666617
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25349402
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24342600
157Wnt signaling pathway_Homo sapiens_hsa043100.24307507
158Vitamin digestion and absorption_Homo sapiens_hsa049770.22471679
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20703153
160Sulfur relay system_Homo sapiens_hsa041220.19652895
161Glycerolipid metabolism_Homo sapiens_hsa005610.19362890
162Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19233856
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19167800

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