MT2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to cadmium ion (GO:0071276)9.28523679
2nucleobase-containing small molecule interconversion (GO:0015949)4.64907360
3membrane raft organization (GO:0031579)4.61617485
4type B pancreatic cell proliferation (GO:0044342)4.52932600
5hemidesmosome assembly (GO:0031581)4.49646927
6ribosomal small subunit biogenesis (GO:0042274)4.45077010
7regulation of metalloenzyme activity (GO:0048552)4.20103032
8response to cadmium ion (GO:0046686)4.12479062
9* response to zinc ion (GO:0010043)4.00379549
10protein maturation by protein folding (GO:0022417)3.96496635
11ribosomal large subunit biogenesis (GO:0042273)3.95228422
12negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.91100770
13pyrimidine nucleoside salvage (GO:0043097)3.77716588
14pyrimidine-containing compound salvage (GO:0008655)3.77716588
15negative regulation of response to reactive oxygen species (GO:1901032)3.68852625
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66480471
17fibrinolysis (GO:0042730)3.60059692
18protein heterotetramerization (GO:0051290)3.52649098
19nucleotide-sugar biosynthetic process (GO:0009226)3.44081744
20cell adhesion mediated by integrin (GO:0033627)3.43476993
21regulation of apoptotic process involved in morphogenesis (GO:1902337)3.41567615
22proteasome assembly (GO:0043248)3.31788048
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.30153381
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29180039
25protein targeting to ER (GO:0045047)3.28568340
26nucleoside salvage (GO:0043174)3.26146989
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25418623
28cotranslational protein targeting to membrane (GO:0006613)3.23616671
29regulation of plasminogen activation (GO:0010755)3.21886938
30viral transcription (GO:0019083)3.21723469
31regulation of hydrogen peroxide-induced cell death (GO:1903205)3.20581870
32skin morphogenesis (GO:0043589)3.19694100
33GDP-mannose metabolic process (GO:0019673)3.19154712
34membrane budding (GO:0006900)3.16346721
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16238229
36protein localization to endoplasmic reticulum (GO:0070972)3.15884632
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14840890
38regulation of integrin-mediated signaling pathway (GO:2001044)3.12964068
39response to redox state (GO:0051775)3.09251387
40chaperone-mediated protein transport (GO:0072321)3.08333107
41translational termination (GO:0006415)3.08094884
42regulation of vitamin D biosynthetic process (GO:0060556)3.06093386
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04306031
44ribonucleoprotein complex biogenesis (GO:0022613)3.00747912
45negative regulation of nitric-oxide synthase activity (GO:0051001)3.00715423
46cyclooxygenase pathway (GO:0019371)2.98588231
47protein localization to endosome (GO:0036010)2.98482010
48negative regulation of anoikis (GO:2000811)2.97011856
49nuclear envelope reassembly (GO:0031468)2.90223603
50mitotic nuclear envelope reassembly (GO:0007084)2.90223603
51regulation of mitotic spindle organization (GO:0060236)2.85556958
52translation (GO:0006412)2.83809578
53regulation of protein export from nucleus (GO:0046825)2.77823047
54endodermal cell differentiation (GO:0035987)2.77255810
55barbed-end actin filament capping (GO:0051016)2.72491321
56desmosome organization (GO:0002934)2.72342678
57regulation of vitamin metabolic process (GO:0030656)2.70720548
58viral life cycle (GO:0019058)2.69778320
59cellular response to interferon-alpha (GO:0035457)2.68335631
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67591297
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65411988
62cell-substrate junction assembly (GO:0007044)2.65128583
63regulation of spindle organization (GO:0090224)2.63300987
64establishment of viral latency (GO:0019043)2.61655686
65translational elongation (GO:0006414)2.60328476
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58630687
67establishment of integrated proviral latency (GO:0075713)2.58621151
68AMP metabolic process (GO:0046033)2.58474741
69nucleotide salvage (GO:0043173)2.58321883
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57454229
71negative regulation of ligase activity (GO:0051352)2.57454229
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56691425
73protein targeting to membrane (GO:0006612)2.56210941
74regulation of anoikis (GO:2000209)2.56060930
75negative regulation of nitric oxide biosynthetic process (GO:0045019)2.54453742
76translational initiation (GO:0006413)2.53717923
77negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.51846015
78pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.51437252
79UMP metabolic process (GO:0046049)2.51437252
80pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.51437252
81UMP biosynthetic process (GO:0006222)2.51437252
82ATP synthesis coupled proton transport (GO:0015986)2.50645089
83energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50645089
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47878784
85regulation of cellular amino acid metabolic process (GO:0006521)2.46957885
86protein targeting to mitochondrion (GO:0006626)2.46861630
872-deoxyribonucleotide biosynthetic process (GO:0009265)2.46652813
88deoxyribose phosphate biosynthetic process (GO:0046385)2.46652813
89negative regulation of fibrinolysis (GO:0051918)2.45134879
90response to copper ion (GO:0046688)2.44755237
91natural killer cell mediated immunity (GO:0002228)2.44739362
92natural killer cell mediated cytotoxicity (GO:0042267)2.44739362
93activation of protein kinase B activity (GO:0032148)2.43852871
94parturition (GO:0007567)2.43757160
95mitotic metaphase plate congression (GO:0007080)2.42745512
96rRNA modification (GO:0000154)2.42236540
97ribosome assembly (GO:0042255)2.40826207
98Golgi transport vesicle coating (GO:0048200)2.39737720
99COPI coating of Golgi vesicle (GO:0048205)2.39737720
100* cellular response to zinc ion (GO:0071294)13.6319213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.87450735
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.58260552
3* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.66726579
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82943650
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68401851
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66503329
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.58884398
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.43404490
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.37235308
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36564577
11* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.32767389
12AR_21909140_ChIP-Seq_LNCAP_Human2.31339707
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30586114
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.20280061
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20100000
16* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.04846840
17* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.04846840
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00516046
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94911459
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94404404
21* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87237431
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85476993
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85208276
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82477881
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81876671
26ZNF263_19887448_ChIP-Seq_K562_Human1.80187651
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78813033
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78508629
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.76915141
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.76797601
31HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.73605582
32ELK1_22589737_ChIP-Seq_MCF10A_Human1.73063129
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71117296
34DCP1A_22483619_ChIP-Seq_HELA_Human1.70953199
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.69812598
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68441379
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68426414
38* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67731037
39* ATF3_27146783_Chip-Seq_COLON_Human1.62875084
40CLOCK_20551151_ChIP-Seq_293T_Human1.60881759
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60600997
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.60390020
43* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59316639
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59108651
45* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57108979
46ELK1_19687146_ChIP-ChIP_HELA_Human1.50998232
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49954814
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48786285
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.48323947
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47495282
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45099758
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45007354
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44782243
54BRD4_25478319_ChIP-Seq_HGPS_Human1.44282267
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36568204
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34650909
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32264185
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30939946
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.28898517
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26876317
61* CJUN_26792858_Chip-Seq_BT549_Human1.26628613
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25940059
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23212691
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22003855
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20000414
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19567590
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18786413
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18260411
69XRN2_22483619_ChIP-Seq_HELA_Human1.17915383
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15897958
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14405858
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.13516748
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13211707
74TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12831241
75GABP_19822575_ChIP-Seq_HepG2_Human1.11832705
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11659703
77* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11017803
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09214009
79* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08930410
80TFEB_21752829_ChIP-Seq_HELA_Human1.07094520
81* RACK7_27058665_Chip-Seq_MCF-7_Human1.07024461
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06774151
83* GATA2_21666600_ChIP-Seq_HMVEC_Human1.06558674
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04620811
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02886265
86* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02031503
87EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01361428
88* SOX2_20726797_ChIP-Seq_SW620_Human1.01211327
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00849774
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00702381
91PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98571043
92EGR1_19374776_ChIP-ChIP_THP-1_Human0.98404989
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97536684
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97444224
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.97321309
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95554459
97ELF5_23300383_ChIP-Seq_T47D_Human0.94696820
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93486245
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.92784942
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92611065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.50955052
2MP0003950_abnormal_plasma_membrane4.96089044
3MP0003705_abnormal_hypodermis_morpholog4.22103079
4MP0010368_abnormal_lymphatic_system3.60792550
5MP0008438_abnormal_cutaneous_collagen3.51757059
6MP0005360_urolithiasis2.81807625
7MP0003566_abnormal_cell_adhesion2.65791354
8MP0003191_abnormal_cellular_cholesterol2.56611201
9MP0005023_abnormal_wound_healing2.51279886
10MP0009780_abnormal_chondrocyte_physiolo2.32865237
11MP0001853_heart_inflammation2.29876421
12MP0010030_abnormal_orbit_morphology2.28437837
13MP0004272_abnormal_basement_membrane2.27034130
14MP0005623_abnormal_meninges_morphology2.25834410
15MP0006054_spinal_hemorrhage2.22997190
16MP0004510_myositis2.15456158
17MP0001879_abnormal_lymphatic_vessel2.14057017
18MP0003941_abnormal_skin_development2.06167310
19MP0003186_abnormal_redox_activity1.96395876
20MP0003279_aneurysm1.95838200
21MP0002060_abnormal_skin_morphology1.90019354
22MP0003453_abnormal_keratinocyte_physiol1.71996969
23MP0009840_abnormal_foam_cell1.70367768
24MP0002877_abnormal_melanocyte_morpholog1.68400957
25MP0000858_altered_metastatic_potential1.65696252
26MP0000343_altered_response_to1.65550358
27MP0005257_abnormal_intraocular_pressure1.59279758
28MP0001542_abnormal_bone_strength1.56879549
29MP0003091_abnormal_cell_migration1.56254697
30MP0005164_abnormal_response_to1.55038849
31MP0009053_abnormal_anal_canal1.54369590
32MP0000750_abnormal_muscle_regeneration1.51338247
33MP0005275_abnormal_skin_tensile1.50455703
34MP0000762_abnormal_tongue_morphology1.48553096
35MP0005451_abnormal_body_composition1.43682711
36MP0008007_abnormal_cellular_replicative1.39765668
37MP0002295_abnormal_pulmonary_circulatio1.36753399
38MP0009697_abnormal_copulation1.34235057
39MP0003075_altered_response_to1.31815675
40MP0001216_abnormal_epidermal_layer1.31496542
41MP0008260_abnormal_autophagy1.18513303
42MP0001958_emphysema1.18163484
43MP0000678_abnormal_parathyroid_gland1.18038031
44MP0005501_abnormal_skin_physiology1.17519232
45MP0002332_abnormal_exercise_endurance1.15776554
46MP0005165_increased_susceptibility_to1.14869811
47MP0005330_cardiomyopathy1.13230865
48MP0005670_abnormal_white_adipose1.12368652
49MP0005595_abnormal_vascular_smooth1.11487901
50MP0003448_altered_tumor_morphology1.09478129
51MP0000733_abnormal_muscle_development1.07292332
52MP0002796_impaired_skin_barrier1.06979793
53MP0000749_muscle_degeneration1.06667470
54MP0004883_abnormal_blood_vessel1.04529295
55MP0009379_abnormal_foot_pigmentation1.01992813
56MP0004947_skin_inflammation1.00241326
57MP0003828_pulmonary_edema0.98864443
58MP0000013_abnormal_adipose_tissue0.98519690
59MP0002148_abnormal_hypersensitivity_rea0.97821728
60MP0001243_abnormal_dermal_layer0.97214932
61MP0001849_ear_inflammation0.94454315
62MP0005166_decreased_susceptibility_to0.93721928
63MP0001881_abnormal_mammary_gland0.90782008
64MP0002896_abnormal_bone_mineralization0.89950233
65MP0006036_abnormal_mitochondrial_physio0.88918137
66MP0010771_integument_phenotype0.85889810
67MP0010352_gastrointestinal_tract_polyps0.84622134
68MP0005375_adipose_tissue_phenotype0.82585306
69MP0000358_abnormal_cell_content/0.82489989
70MP0002234_abnormal_pharynx_morphology0.81026911
71MP0003077_abnormal_cell_cycle0.80396707
72MP0004233_abnormal_muscle_weight0.79200769
73MP0000579_abnormal_nail_morphology0.78906113
74MP0004957_abnormal_blastocyst_morpholog0.78033203
75MP0009785_altered_susceptibility_to0.76894388
76MP0005193_abnormal_anterior_eye0.73917463
77MP0005666_abnormal_adipose_tissue0.72956401
78MP0005621_abnormal_cell_physiology0.72825794
79MP0003011_delayed_dark_adaptation0.72365117
80MP0002938_white_spotting0.71101658
81MP0000767_abnormal_smooth_muscle0.70265858
82MP0009763_increased_sensitivity_to0.68300128
83MP0005058_abnormal_lysosome_morphology0.68101924
84MP0000350_abnormal_cell_proliferation0.68062850
85MP0005508_abnormal_skeleton_morphology0.66734713
86MP0005584_abnormal_enzyme/coenzyme_acti0.66523008
87MP0001851_eye_inflammation0.63618247
88MP0009931_abnormal_skin_appearance0.63174605
89MP0000759_abnormal_skeletal_muscle0.62340157
90MP0005197_abnormal_uvea_morphology0.61833691
91MP0000003_abnormal_adipose_tissue0.61792636
92MP0000627_abnormal_mammary_gland0.61382744
93MP0009250_abnormal_appendicular_skeleto0.60901440
94MP0003045_fibrosis0.60894901
95MP0005395_other_phenotype0.60744794
96MP0003786_premature_aging0.60191187
97MP0009764_decreased_sensitivity_to0.59981722
98MP0010234_abnormal_vibrissa_follicle0.59947105
99MP0008875_abnormal_xenobiotic_pharmacok0.59942364
100MP0005408_hypopigmentation0.59911352

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.95661243
2Atrophic scars (HP:0001075)3.88353964
3Reduced subcutaneous adipose tissue (HP:0003758)3.62516549
4Onycholysis (HP:0001806)3.41900021
5Ankle contracture (HP:0006466)3.33773375
6Axonal loss (HP:0003447)3.31076777
7Abnormality of the intrinsic pathway (HP:0010989)3.26420769
8Protrusio acetabuli (HP:0003179)3.20954148
9Fragile nails (HP:0001808)3.18282406
10Amniotic constriction ring (HP:0009775)3.14894864
11Abnormality of placental membranes (HP:0011409)3.14894864
12Milia (HP:0001056)3.12418058
13Vertebral compression fractures (HP:0002953)3.05972790
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.02185586
15Nail dystrophy (HP:0008404)3.01493376
16Follicular hyperkeratosis (HP:0007502)2.89732750
17Generalized amyotrophy (HP:0003700)2.75895554
18Acute necrotizing encephalopathy (HP:0006965)2.75030878
19Vascular tortuosity (HP:0004948)2.73324175
20Rough bone trabeculation (HP:0100670)2.71878923
21Fragile skin (HP:0001030)2.71328800
22Abnormal mitochondria in muscle tissue (HP:0008316)2.69668041
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65533082
24Natal tooth (HP:0000695)2.62416226
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62011898
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62011898
27Reduced antithrombin III activity (HP:0001976)2.58533122
28Abnormality of cells of the erythroid lineage (HP:0012130)2.56378188
29Alopecia of scalp (HP:0002293)2.55493255
30Lip pit (HP:0100267)2.54366143
31Decreased subcutaneous fat (HP:0001002)2.53692102
32Cardiovascular calcification (HP:0011915)2.50607453
33Congenital ichthyosiform erythroderma (HP:0007431)2.48789581
34Osteolytic defects of the hand bones (HP:0009699)2.44334843
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.44334843
36Cervical subluxation (HP:0003308)2.41306038
37Type I transferrin isoform profile (HP:0003642)2.40225444
38Vascular calcification (HP:0004934)2.38380533
39Short nail (HP:0001799)2.35241206
40Sparse eyelashes (HP:0000653)2.31727820
41Stenosis of the external auditory canal (HP:0000402)2.29677940
42Spinal cord compression (HP:0002176)2.29040797
43Spinal rigidity (HP:0003306)2.28438721
44Renal Fanconi syndrome (HP:0001994)2.25051181
45Glucose intolerance (HP:0000833)2.24728761
46Abnormalities of placenta or umbilical cord (HP:0001194)2.22921475
47Abnormal trabecular bone morphology (HP:0100671)2.22582960
48Progressive macrocephaly (HP:0004481)2.21092485
49Thick nail (HP:0001805)2.19429654
50Wormian bones (HP:0002645)2.18566223
51Posterior subcapsular cataract (HP:0007787)2.17453394
52Acute encephalopathy (HP:0006846)2.17011184
53Neoplasm of head and neck (HP:0012288)2.16996391
54Esophageal neoplasm (HP:0100751)2.16996391
55Prolonged partial thromboplastin time (HP:0003645)2.14564315
56Entropion (HP:0000621)2.13592918
57Trismus (HP:0000211)2.13553377
58Mitochondrial inheritance (HP:0001427)2.10597725
59Bone cyst (HP:0012062)2.09904077
60Elbow flexion contracture (HP:0002987)2.07541918
61Distal lower limb muscle weakness (HP:0009053)2.06890928
62Palpitations (HP:0001962)2.05681505
63Plantar hyperkeratosis (HP:0007556)2.02877965
64Abnormality of subcutaneous fat tissue (HP:0001001)2.01498765
65Distal lower limb amyotrophy (HP:0008944)2.00946958
66Achilles tendon contracture (HP:0001771)2.00562710
67Testicular atrophy (HP:0000029)2.00485261
68Macrocytic anemia (HP:0001972)2.00158045
69Hypertensive crisis (HP:0100735)1.99791212
70Renal duplication (HP:0000075)1.97317774
71Generalized aminoaciduria (HP:0002909)1.96954953
72Hypoplasia of dental enamel (HP:0006297)1.96339564
73Aortic aneurysm (HP:0004942)1.95574258
74Conjunctival hamartoma (HP:0100780)1.93866271
75Hyperparathyroidism (HP:0000843)1.93389405
76Acanthosis nigricans (HP:0000956)1.92771886
77Abnormality of methionine metabolism (HP:0010901)1.92242998
78Blue sclerae (HP:0000592)1.90769472
79Arterial tortuosity (HP:0005116)1.90559633
80Abnormality of the umbilical cord (HP:0010881)1.90247722
81Oral leukoplakia (HP:0002745)1.83797882
82Abnormal gallbladder physiology (HP:0012438)1.83245187
83Cholecystitis (HP:0001082)1.83245187
84Abnormality of the Achilles tendon (HP:0005109)1.83143043
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83045321
86Aortic dissection (HP:0002647)1.81215834
87Exercise intolerance (HP:0003546)1.78082608
88Insulin resistance (HP:0000855)1.77662522
89Chondrocalcinosis (HP:0000934)1.76867891
90Abnormality of complement system (HP:0005339)1.75310835
91Abnormality of carpal bone ossification (HP:0006257)1.75200075
92Poikiloderma (HP:0001029)1.74540893
93Exertional dyspnea (HP:0002875)1.74352829
94Bladder diverticulum (HP:0000015)1.73472934
95Abnormality of Sharpey fibers (HP:0100685)1.73242263
96Abnormal number of erythroid precursors (HP:0012131)1.73025927
97Brittle hair (HP:0002299)1.72963928
98Increased CSF lactate (HP:0002490)1.70201962
99Hypoplastic pelvis (HP:0008839)1.70088373
100Abnormal blistering of the skin (HP:0008066)1.69934625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF4.09242895
2NME23.62721309
3IRAK33.17401926
4MAP3K123.02071037
5BUB12.92723820
6PAK42.73862071
7PIM22.71345511
8NEK12.47797765
9TESK12.41014194
10PTK22.31262799
11MST1R2.28796646
12MST42.26980598
13LATS22.25143614
14MYLK2.22760079
15MAP3K32.21497534
16MOS2.21371339
17ABL22.15072434
18EPHA22.06776199
19TGFBR22.06540901
20LIMK12.02965176
21MET1.88403964
22EPHB21.87630305
23PDGFRA1.75302157
24ERBB41.73504603
25EIF2AK11.66573732
26RIPK11.66095542
27ILK1.62330334
28STK161.61411311
29LMTK21.54961927
30VRK21.52719750
31BRAF1.52585541
32PBK1.50658576
33FLT31.49404237
34NTRK11.34841424
35STK101.25980332
36ERN11.22778479
37DDR21.21038860
38TAOK21.20321821
39EIF2AK31.07447369
40PAK21.06508988
41EPHB10.98714871
42CLK10.97934587
43PRPF4B0.93085669
44PDK20.85075100
45PAK10.76706518
46PRKG20.76520625
47AURKA0.75528016
48GRK70.75013422
49CDK80.71334127
50MAP3K90.70253975
51MAP3K80.69014920
52RAF10.68733375
53TESK20.68357591
54PAK60.68196134
55MUSK0.67227456
56DMPK0.66211884
57TTN0.64925177
58PRKCI0.63047778
59ADRBK10.62640831
60STK240.62010646
61ROCK20.61812246
62STK380.60793597
63PTK2B0.58722495
64CCNB10.57172865
65MAP2K30.56421506
66MAP3K130.55799207
67CDK90.51036401
68GSK3A0.50377816
69PHKG10.49134919
70PHKG20.49134919
71DAPK30.49132317
72EIF2AK20.49107624
73AKT20.49077948
74CDC70.48756884
75BRSK10.47385964
76AURKB0.46961484
77CAMK2G0.46917236
78BMX0.43626836
79ROCK10.43556061
80NEK20.43174244
81TBK10.42800223
82BCKDK0.40963366
83PDGFRB0.40187460
84TRIB30.39011271
85NEK90.38117978
86SIK10.37887719
87NME10.36456994
88DAPK10.32785164
89PLK10.32449677
90GRK50.30115566
91MAPKAPK20.29604453
92MELK0.28241008
93STK40.27558963
94LRRK20.27319071
95SRPK10.24930430
96CSNK1A1L0.24161315
97CDC42BPA0.23665189
98PLK30.23607949
99PRKD20.22822933
100PTK60.22230879

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.53469454
2Proteasome_Homo sapiens_hsa030504.04222155
3* Mineral absorption_Homo sapiens_hsa049783.63166645
4Protein export_Homo sapiens_hsa030602.93772642
5Nucleotide excision repair_Homo sapiens_hsa034202.68453301
6Oxidative phosphorylation_Homo sapiens_hsa001902.67941425
7Sulfur metabolism_Homo sapiens_hsa009202.59017587
8Folate biosynthesis_Homo sapiens_hsa007902.11417638
9Parkinsons disease_Homo sapiens_hsa050122.05517565
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.95385740
11Glutathione metabolism_Homo sapiens_hsa004801.92301587
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86385592
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74398152
14Pyrimidine metabolism_Homo sapiens_hsa002401.71696077
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.70843982
16Alzheimers disease_Homo sapiens_hsa050101.70280845
17DNA replication_Homo sapiens_hsa030301.67306617
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66857974
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66656128
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63329367
21Huntingtons disease_Homo sapiens_hsa050161.55851701
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51857265
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49626059
24Shigellosis_Homo sapiens_hsa051311.48311424
25Mismatch repair_Homo sapiens_hsa034301.43859533
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40288019
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40157218
28Complement and coagulation cascades_Homo sapiens_hsa046101.38135076
29ECM-receptor interaction_Homo sapiens_hsa045121.35304606
30RNA polymerase_Homo sapiens_hsa030201.32010533
31Galactose metabolism_Homo sapiens_hsa000521.31377225
32Salmonella infection_Homo sapiens_hsa051321.29055525
33Fructose and mannose metabolism_Homo sapiens_hsa000511.26185201
34Chemical carcinogenesis_Homo sapiens_hsa052041.24243911
35Pentose phosphate pathway_Homo sapiens_hsa000301.19219082
36One carbon pool by folate_Homo sapiens_hsa006701.18403951
37Sulfur relay system_Homo sapiens_hsa041221.16920856
38Focal adhesion_Homo sapiens_hsa045101.12485098
39Vibrio cholerae infection_Homo sapiens_hsa051101.11374610
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11047126
41N-Glycan biosynthesis_Homo sapiens_hsa005101.03020515
42Prion diseases_Homo sapiens_hsa050200.99643749
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98954943
44p53 signaling pathway_Homo sapiens_hsa041150.95773105
45Proteoglycans in cancer_Homo sapiens_hsa052050.91689480
46Homologous recombination_Homo sapiens_hsa034400.83643476
47Small cell lung cancer_Homo sapiens_hsa052220.82603795
48Vitamin B6 metabolism_Homo sapiens_hsa007500.81356191
49Bladder cancer_Homo sapiens_hsa052190.81078271
50Pertussis_Homo sapiens_hsa051330.81063019
51Base excision repair_Homo sapiens_hsa034100.78580300
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74954323
53Malaria_Homo sapiens_hsa051440.74949803
54Tyrosine metabolism_Homo sapiens_hsa003500.70819724
55TNF signaling pathway_Homo sapiens_hsa046680.67783128
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67535793
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67171321
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66602744
59Phenylalanine metabolism_Homo sapiens_hsa003600.64867063
60Amoebiasis_Homo sapiens_hsa051460.64136746
61Legionellosis_Homo sapiens_hsa051340.64093157
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61547782
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59567359
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.59496840
65Renal cell carcinoma_Homo sapiens_hsa052110.58768431
66Circadian rhythm_Homo sapiens_hsa047100.58154875
67Basal transcription factors_Homo sapiens_hsa030220.56856830
68PPAR signaling pathway_Homo sapiens_hsa033200.56139952
69Carbon metabolism_Homo sapiens_hsa012000.55794335
70Biosynthesis of amino acids_Homo sapiens_hsa012300.54815441
71Apoptosis_Homo sapiens_hsa042100.54006097
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.52600201
73HIF-1 signaling pathway_Homo sapiens_hsa040660.52306824
74Endocytosis_Homo sapiens_hsa041440.50251830
75African trypanosomiasis_Homo sapiens_hsa051430.49296963
76Fatty acid elongation_Homo sapiens_hsa000620.48783505
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47505713
78Metabolic pathways_Homo sapiens_hsa011000.46567167
79Pyruvate metabolism_Homo sapiens_hsa006200.43200403
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42172756
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41827163
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41218721
83Rheumatoid arthritis_Homo sapiens_hsa053230.40945674
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40664320
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39976983
86Cardiac muscle contraction_Homo sapiens_hsa042600.39798459
87Cell cycle_Homo sapiens_hsa041100.37515157
88RNA transport_Homo sapiens_hsa030130.35853281
89Purine metabolism_Homo sapiens_hsa002300.35636556
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.35128789
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34663342
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33879304
93Fatty acid degradation_Homo sapiens_hsa000710.32816375
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32740438
95Arachidonic acid metabolism_Homo sapiens_hsa005900.31240048
96Adherens junction_Homo sapiens_hsa045200.31039570
97Lysosome_Homo sapiens_hsa041420.30998886
98Spliceosome_Homo sapiens_hsa030400.30372795
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30050594
100Starch and sucrose metabolism_Homo sapiens_hsa005000.29102602

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