MT1JP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to zinc ion (GO:0010043)5.85898187
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.62962372
3L-phenylalanine catabolic process (GO:0006559)5.62962372
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.48501190
5L-phenylalanine metabolic process (GO:0006558)5.48501190
6response to cadmium ion (GO:0046686)4.52410318
7glucosamine-containing compound catabolic process (GO:1901072)4.47657582
8xenobiotic catabolic process (GO:0042178)3.96539357
9aromatic amino acid family catabolic process (GO:0009074)3.62111086
10cellular zinc ion homeostasis (GO:0006882)3.59698449
11regulation of mononuclear cell migration (GO:0071675)3.58557214
12eosinophil chemotaxis (GO:0048245)3.45556790
13regulation of sequestering of triglyceride (GO:0010889)3.32413572
14production of molecular mediator involved in inflammatory response (GO:0002532)3.31998923
15amino sugar catabolic process (GO:0046348)3.29842016
16negative regulation of execution phase of apoptosis (GO:1900118)3.24270077
17low-density lipoprotein particle clearance (GO:0034383)3.23219413
18lipid storage (GO:0019915)3.18761847
19response to nitrosative stress (GO:0051409)3.10955655
20eosinophil migration (GO:0072677)3.00670061
21regulation of triglyceride catabolic process (GO:0010896)3.00041572
22response to hydroperoxide (GO:0033194)2.94342454
23acute-phase response (GO:0006953)2.90619555
24arginine catabolic process (GO:0006527)2.88295185
25cellular response to arsenic-containing substance (GO:0071243)2.86758132
26positive regulation of lipid storage (GO:0010884)2.84856427
27positive regulation of triglyceride metabolic process (GO:0090208)2.77201294
28zinc ion homeostasis (GO:0055069)2.68875764
29regulation of phospholipase A2 activity (GO:0032429)2.67944898
30response to transition metal nanoparticle (GO:1990267)2.67393214
31triglyceride catabolic process (GO:0019433)2.61369677
32negative regulation of complement activation (GO:0045916)2.59844303
33cellular response to metal ion (GO:0071248)2.58217140
34lipid particle organization (GO:0034389)2.56963109
35positive regulation of chemokine secretion (GO:0090197)2.56394252
36cellular ketone body metabolic process (GO:0046950)2.54243580
37zinc ion transport (GO:0006829)2.53862456
38digestion (GO:0007586)2.50900588
39negative regulation of protein activation cascade (GO:2000258)2.49570652
40alanine transport (GO:0032328)2.47106133
41regulation of type B pancreatic cell apoptotic process (GO:2000674)2.44578452
42aromatic amino acid family metabolic process (GO:0009072)2.42685833
43cell wall macromolecule metabolic process (GO:0044036)2.42110456
44negative regulation of membrane potential (GO:0045837)2.41904714
45regulation of vitamin D biosynthetic process (GO:0060556)2.40850434
46positive regulation of triglyceride biosynthetic process (GO:0010867)2.40671308
47complement activation, alternative pathway (GO:0006957)2.40395114
48fatty acid homeostasis (GO:0055089)2.40339087
49negative regulation of viral entry into host cell (GO:0046597)2.39783022
50zinc ion transmembrane transport (GO:0071577)2.39421845
51C4-dicarboxylate transport (GO:0015740)2.38453730
52regulation of integrin-mediated signaling pathway (GO:2001044)2.38407708
53acylglycerol catabolic process (GO:0046464)2.37576384
54neutral lipid catabolic process (GO:0046461)2.37576384
55triglyceride homeostasis (GO:0070328)2.36525088
56acylglycerol homeostasis (GO:0055090)2.36525088
57lymphocyte chemotaxis (GO:0048247)2.35994388
58tyrosine metabolic process (GO:0006570)2.35908469
59negative regulation of lipid catabolic process (GO:0050995)2.35897289
60pyrimidine-containing compound salvage (GO:0008655)2.34958769
61pyrimidine nucleoside salvage (GO:0043097)2.34958769
62fibrinolysis (GO:0042730)2.29814482
63lipopolysaccharide biosynthetic process (GO:0009103)2.28864889
64fat-soluble vitamin biosynthetic process (GO:0042362)2.28772309
65regulation of transmission of nerve impulse (GO:0051969)2.28260051
66macrophage chemotaxis (GO:0048246)2.27840455
67opsonization (GO:0008228)2.27167136
68regulation of metalloenzyme activity (GO:0048552)2.26473605
69acute inflammatory response (GO:0002526)2.26131812
70regulation of macrophage chemotaxis (GO:0010758)2.25509048
71signal peptide processing (GO:0006465)2.24569061
72response to dietary excess (GO:0002021)2.23256599
73DNA deamination (GO:0045006)2.20557835
74regulation of chemokine secretion (GO:0090196)2.20487262
75cellular response to inorganic substance (GO:0071241)2.20112976
76negative regulation of lipase activity (GO:0060192)2.19586876
77dicarboxylic acid biosynthetic process (GO:0043650)2.18305123
78mannosylation (GO:0097502)2.17298995
79iron ion import (GO:0097286)2.17258609
80regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.15880512
81adhesion of symbiont to host cell (GO:0044650)2.15819930
82virion attachment to host cell (GO:0019062)2.15819930
83regulation of triglyceride biosynthetic process (GO:0010866)2.15814899
84regulation of triglyceride metabolic process (GO:0090207)2.14500378
85negative regulation of protein autophosphorylation (GO:0031953)2.14117213
86biotin metabolic process (GO:0006768)2.14050213
87vitamin biosynthetic process (GO:0009110)2.13984829
88regulation of chemokine biosynthetic process (GO:0045073)2.13427292
89transcytosis (GO:0045056)2.13303046
90ketone body metabolic process (GO:1902224)2.13247838
91negative regulation of focal adhesion assembly (GO:0051895)2.11592442
92negative regulation of cell junction assembly (GO:1901889)2.11592442
93negative regulation of adherens junction organization (GO:1903392)2.11592442
94glycerolipid catabolic process (GO:0046503)2.11308224
95glutathione derivative metabolic process (GO:1901685)2.11085805
96glutathione derivative biosynthetic process (GO:1901687)2.11085805
97negative regulation of lipid storage (GO:0010888)2.10879354
98cofactor catabolic process (GO:0051187)2.10161449
99cellular response to zinc ion (GO:0071294)16.4400810
100cellular response to cadmium ion (GO:0071276)10.7425624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.12046058
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00195170
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.94777315
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.85916553
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47799475
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.71701379
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57833153
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57099860
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.54223588
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.35604112
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35388148
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.27237553
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23435980
14ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.20275796
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13408153
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09155600
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96688556
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95346525
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94642168
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92755206
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89239635
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.85160811
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80678474
24SOX2_20726797_ChIP-Seq_SW620_Human1.78774004
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.69284608
26CJUN_26792858_Chip-Seq_BT549_Human1.67793238
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62249835
28BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.57867951
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54566807
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.53034119
31JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50305987
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.50007692
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44443541
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44259022
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43148154
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.42368689
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.42195338
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41734149
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37866217
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33643656
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33349711
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31912397
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28694197
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.27499018
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26716046
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25319560
47HTT_18923047_ChIP-ChIP_STHdh_Human1.23503061
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19383211
49STAT1_20625510_ChIP-Seq_HELA_Human1.16084319
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.15374613
51CLOCK_20551151_ChIP-Seq_293T_Human1.12709619
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12581231
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11920269
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11920269
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11398550
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.09720746
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09360432
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08596756
59CSB_26484114_Chip-Seq_FIBROBLAST_Human1.05793113
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.04060405
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03994573
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03637115
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00092988
64CBP_21632823_ChIP-Seq_H3396_Human0.99339543
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97969265
66STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97660053
67FOXH1_21741376_ChIP-Seq_EPCs_Human0.97187247
68RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96712163
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96340028
70RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94175877
71FOXA1_25329375_ChIP-Seq_VCAP_Human0.94133653
72FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94133653
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93267114
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91362005
75ATF3_27146783_Chip-Seq_COLON_Human0.88165340
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87977615
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87673832
78AR_20517297_ChIP-Seq_VCAP_Human0.86942581
79BCAT_22108803_ChIP-Seq_LS180_Human0.86527632
80MYC_19829295_ChIP-Seq_ESCs_Human0.84353898
81ESR1_20079471_ChIP-ChIP_T-47D_Human0.83393206
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83013482
83BCOR_27268052_Chip-Seq_Bcells_Human0.82431045
84GATA4_25053715_ChIP-Seq_YYC3_Human0.80839373
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80498871
86SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80063582
87CTCF_20526341_ChIP-Seq_ESCs_Human0.79870646
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.77747898
89TFEB_21752829_ChIP-Seq_HELA_Human0.77536945
90NCOR_22424771_ChIP-Seq_293T_Human0.76024606
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.75143071
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.74586522
93AHR_22903824_ChIP-Seq_MCF-7_Human0.73625715
94CDX2_22108803_ChIP-Seq_LS180_Human0.73573987
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.73287373
96SA1_27219007_Chip-Seq_Bcells_Human0.72958914
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72640435
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71975119
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71837150
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.71620211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.28731829
2MP0003195_calcinosis3.87669952
3MP0003806_abnormal_nucleotide_metabolis3.18200418
4MP0009785_altered_susceptibility_to3.02257652
5MP0002139_abnormal_hepatobiliary_system2.78966470
6MP0000343_altered_response_to2.73625297
7MP0004510_myositis2.65345854
8MP0009840_abnormal_foam_cell2.44544370
9MP0005670_abnormal_white_adipose2.36350938
10MP0003950_abnormal_plasma_membrane2.35371227
11MP0001853_heart_inflammation2.30529190
12MP0005058_abnormal_lysosome_morphology2.24101926
13MP0002148_abnormal_hypersensitivity_rea2.08513619
14MP0005332_abnormal_amino_acid2.05978116
15MP0008875_abnormal_xenobiotic_pharmacok2.04005173
16MP0003011_delayed_dark_adaptation2.01633235
17MP0005365_abnormal_bile_salt1.99046748
18MP0003075_altered_response_to1.95554013
19MP0005167_abnormal_blood-brain_barrier1.91835031
20MP0006082_CNS_inflammation1.88787552
21MP0002971_abnormal_brown_adipose1.88145566
22MP0009764_decreased_sensitivity_to1.86330019
23MP0003186_abnormal_redox_activity1.75499833
24MP0002909_abnormal_adrenal_gland1.60297083
25MP0001764_abnormal_homeostasis1.59936863
26MP0005023_abnormal_wound_healing1.56127191
27MP0005666_abnormal_adipose_tissue1.52388739
28MP0003436_decreased_susceptibility_to1.51022949
29MP0002254_reproductive_system_inflammat1.49593413
30MP0005164_abnormal_response_to1.47390731
31MP0010329_abnormal_lipoprotein_level1.44012296
32MP0000604_amyloidosis1.42826441
33MP0006036_abnormal_mitochondrial_physio1.38025200
34MP0008469_abnormal_protein_level1.36210693
35MP0005360_urolithiasis1.36183640
36MP0005584_abnormal_enzyme/coenzyme_acti1.33018162
37MP0005166_decreased_susceptibility_to1.30580396
38MP0004019_abnormal_vitamin_homeostasis1.30357690
39MP0001533_abnormal_skeleton_physiology1.28461421
40MP0003045_fibrosis1.27106090
41MP0006072_abnormal_retinal_apoptosis1.26058437
42MP0005595_abnormal_vascular_smooth1.25788637
43MP0005387_immune_system_phenotype1.24359716
44MP0001790_abnormal_immune_system1.24359716
45MP0008004_abnormal_stomach_pH1.23956138
46MP0001845_abnormal_inflammatory_respons1.23242154
47MP0002295_abnormal_pulmonary_circulatio1.23143984
48MP0010368_abnormal_lymphatic_system1.21747025
49MP0005535_abnormal_body_temperature1.19915523
50MP0002419_abnormal_innate_immunity1.17769449
51MP0001501_abnormal_sleep_pattern1.16723366
52MP0005334_abnormal_fat_pad1.15012179
53MP0002118_abnormal_lipid_homeostasis1.14815362
54MP0005000_abnormal_immune_tolerance1.13848868
55MP0005448_abnormal_energy_balance1.13374928
56MP0002693_abnormal_pancreas_physiology1.13045986
57MP0003633_abnormal_nervous_system1.12358628
58MP0003191_abnormal_cellular_cholesterol1.12138965
59MP0002970_abnormal_white_adipose1.11248547
60MP0005379_endocrine/exocrine_gland_phen1.09877210
61MP0005375_adipose_tissue_phenotype1.08985270
62MP0002998_abnormal_bone_remodeling1.07670222
63MP0009333_abnormal_splenocyte_physiolog1.07642839
64MP0001542_abnormal_bone_strength1.07436042
65MP0009643_abnormal_urine_homeostasis1.07054176
66MP0005410_abnormal_fertilization1.06536603
67MP0009763_increased_sensitivity_to1.06345576
68MP0005025_abnormal_response_to1.05259838
69MP0004883_abnormal_blood_vessel1.05071614
70MP0009046_muscle_twitch1.04236352
71MP0004947_skin_inflammation1.04036624
72MP0002168_other_aberrant_phenotype1.03837329
73MP0005319_abnormal_enzyme/_coenzyme1.01546330
74MP0003453_abnormal_keratinocyte_physiol1.01003848
75MP0010234_abnormal_vibrissa_follicle1.00576683
76MP0002078_abnormal_glucose_homeostasis0.99929025
77MP0000609_abnormal_liver_physiology0.97871736
78MP0000427_abnormal_hair_cycle0.97861382
79MP0003724_increased_susceptibility_to0.97376351
80MP0005165_increased_susceptibility_to0.95823651
81MP0010307_abnormal_tumor_latency0.95614091
82MP0005636_abnormal_mineral_homeostasis0.95137289
83MP0008775_abnormal_heart_ventricle0.91882373
84MP0005376_homeostasis/metabolism_phenot0.91521590
85MP0000685_abnormal_immune_system0.90633383
86MP0003303_peritoneal_inflammation0.90465870
87MP0005397_hematopoietic_system_phenotyp0.89528553
88MP0001545_abnormal_hematopoietic_system0.89528553
89MP0003448_altered_tumor_morphology0.88794014
90MP0010678_abnormal_skin_adnexa0.88517359
91MP0008438_abnormal_cutaneous_collagen0.87846650
92MP0003279_aneurysm0.86604075
93MP0009278_abnormal_bone_marrow0.84250782
94MP0001756_abnormal_urination0.82082790
95MP0005671_abnormal_response_to0.80725391
96MP0001944_abnormal_pancreas_morphology0.79436701
97MP0002138_abnormal_hepatobiliary_system0.79149827
98MP0001881_abnormal_mammary_gland0.78788920
99MP0003329_amyloid_beta_deposits0.78362746
100MP0009765_abnormal_xenobiotic_induced0.77010684

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.14924708
2Abnormality of liposaccharide metabolism (HP:0010968)4.17132525
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.17132525
4Abnormality of glycolipid metabolism (HP:0010969)4.17132525
5Systemic lupus erythematosus (HP:0002725)3.71055894
6Complement deficiency (HP:0004431)3.36445590
7Xanthomatosis (HP:0000991)3.21828410
8Vacuolated lymphocytes (HP:0001922)3.06719579
9Progressive neurologic deterioration (HP:0002344)3.03912120
10Renal Fanconi syndrome (HP:0001994)3.03652253
11Insulin-resistant diabetes mellitus (HP:0000831)2.98263768
12Hypokinesia (HP:0002375)2.87281844
13Abnormality of monocarboxylic acid metabolism (HP:0010996)2.81257025
14Opisthotonus (HP:0002179)2.79443136
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.72900098
16Abnormal protein N-linked glycosylation (HP:0012347)2.72900098
17Abnormal protein glycosylation (HP:0012346)2.72900098
18Abnormal glycosylation (HP:0012345)2.72900098
19Abnormality of complement system (HP:0005339)2.69906416
20Dysostosis multiplex (HP:0000943)2.64409020
21Hepatic necrosis (HP:0002605)2.64383290
223-Methylglutaconic aciduria (HP:0003535)2.59668289
23Hepatocellular necrosis (HP:0001404)2.56868199
24Acute hepatic failure (HP:0006554)2.51066465
25Axonal loss (HP:0003447)2.49276433
26Ketoacidosis (HP:0001993)2.47933578
27Vascular calcification (HP:0004934)2.46512054
28Bone cyst (HP:0012062)2.45256011
29Recurrent gram-negative bacterial infections (HP:0005420)2.43717811
30Symptomatic seizures (HP:0011145)2.40394661
31Hypertriglyceridemia (HP:0002155)2.39507988
32Mitochondrial inheritance (HP:0001427)2.38283504
33Epidermoid cyst (HP:0200040)2.37295672
34Abnormality of polysaccharide metabolism (HP:0011012)2.36985192
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36985192
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36985192
37Generalized aminoaciduria (HP:0002909)2.36029463
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32425776
39Glomerulonephritis (HP:0000099)2.31488164
40Hyperglycemia (HP:0003074)2.30560589
41Hematochezia (HP:0002573)2.29060261
42Hyperinsulinemic hypoglycemia (HP:0000825)2.28584073
43Insulin resistance (HP:0000855)2.26246502
44Ketosis (HP:0001946)2.26234866
45Horizontal nystagmus (HP:0000666)2.23609057
46Increased muscle lipid content (HP:0009058)2.22532177
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22040365
48Cardiovascular calcification (HP:0011915)2.21664006
49Increased CSF protein (HP:0002922)2.20427701
50Episodic fever (HP:0001954)2.18226778
51Mucopolysacchariduria (HP:0008155)2.16488045
52Urinary glycosaminoglycan excretion (HP:0003541)2.16488045
53Abnormality of renal resorption (HP:0011038)2.12637873
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12371719
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12371719
56Abnormality of macrophages (HP:0004311)2.11345011
57Hyperlipoproteinemia (HP:0010980)2.10668713
58Myocardial infarction (HP:0001658)2.08911192
59Craniofacial dystonia (HP:0012179)2.08236447
60Focal dystonia (HP:0004373)2.08187426
61Pancreatic islet-cell hyperplasia (HP:0004510)2.07854749
62Torticollis (HP:0000473)2.07038917
63Acute necrotizing encephalopathy (HP:0006965)2.06396168
64Hyperammonemia (HP:0001987)2.05968853
65Acanthosis nigricans (HP:0000956)2.04929921
66Hypoglycemic seizures (HP:0002173)2.04081851
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02894191
68Dicarboxylic aciduria (HP:0003215)1.99633954
69Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99633954
70Abnormality of the basal ganglia (HP:0002134)1.98128772
71Petechiae (HP:0000967)1.97252670
72Abnormality of alanine metabolism (HP:0010916)1.96627523
73Hyperalaninemia (HP:0003348)1.96627523
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96627523
75Abnormal mitochondria in muscle tissue (HP:0008316)1.96217718
76Prolonged neonatal jaundice (HP:0006579)1.94222415
77Severe visual impairment (HP:0001141)1.94122516
78Glucose intolerance (HP:0000833)1.91670674
79Conjugated hyperbilirubinemia (HP:0002908)1.91548244
80Progressive macrocephaly (HP:0004481)1.91134519
81Type I transferrin isoform profile (HP:0003642)1.90028834
82Hypoglycemic coma (HP:0001325)1.89671597
83Pendular nystagmus (HP:0012043)1.89403953
84Prolonged partial thromboplastin time (HP:0003645)1.89201059
85Glycosuria (HP:0003076)1.88574223
86Abnormality of urine glucose concentration (HP:0011016)1.88574223
87Abnormality of pyrimidine metabolism (HP:0004353)1.85153234
88Increased CSF lactate (HP:0002490)1.83748828
89Hemiparesis (HP:0001269)1.83642768
90Lipid accumulation in hepatocytes (HP:0006561)1.83506607
91CNS demyelination (HP:0007305)1.82258147
92Abnormality of the pancreatic islet cells (HP:0006476)1.81564444
93Abnormality of endocrine pancreas physiology (HP:0012093)1.81564444
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81492739
95Joint hemorrhage (HP:0005261)1.81190584
96Abnormality of the periventricular white matter (HP:0002518)1.79713367
97Ileus (HP:0002595)1.79043470
98Congenital sensorineural hearing impairment (HP:0008527)1.78650053
99Abnormal glucose tolerance (HP:0001952)1.77892761
100Malnutrition (HP:0004395)1.75984786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.51822624
2MUSK4.49957120
3MAP3K33.03381654
4FRK2.51193436
5IRAK32.41965565
6MAP4K22.16647582
7PDK22.10237383
8MAP3K132.08722176
9TESK12.06100300
10MYLK1.93255531
11ERBB41.92579748
12NME21.91981636
13KDR1.84543147
14MST41.84081435
15LIMK11.78493397
16MAP3K111.66384270
17ADRBK21.60712759
18GRK71.59667598
19TAOK21.57338529
20ERN11.56755416
21BLK1.53157296
22ABL21.51032462
23IKBKB1.48686694
24TGFBR21.46379829
25TESK21.38817661
26EIF2AK31.36054745
27FER1.34998603
28MAP3K91.31444268
29GSK3A1.30342266
30ARAF1.23696183
31TRPM71.23246922
32GRK11.20469414
33DDR21.18103301
34MOS1.15727122
35MAP3K11.14839685
36PHKG21.14101204
37PHKG11.14101204
38LMTK21.13821377
39PAK41.12697068
40ZAK1.11598177
41EPHA31.10459220
42PRKG21.07877810
43EPHB11.06966417
44IRAK11.04851699
45MARK31.02127494
46BCKDK1.00756365
47MAP3K141.00049060
48CLK10.99932523
49MAPKAPK30.98226727
50STK160.96551761
51PINK10.96239816
52DAPK20.91654076
53MAP3K50.88871087
54PIM20.88806610
55JAK10.86165878
56TAOK10.86130258
57ZAP700.86088795
58ADRBK10.85810585
59CSK0.85496465
60PRKAA20.83458172
61PKN10.80935663
62TBK10.78691411
63MAP3K20.77651058
64CAMK2G0.76931538
65AKT30.69710547
66IKBKE0.64980359
67CHUK0.64133384
68CAMK2D0.63927194
69EPHA20.62608232
70DAPK10.61975192
71MST1R0.60851443
72PTK20.60245978
73SCYL20.59891936
74BUB10.57934510
75TYK20.56403544
76CAMKK20.55978324
77PDK10.55229657
78TLK10.54252315
79PAK30.51058253
80ABL10.49972716
81BMPR20.47995978
82PAK10.47243608
83HIPK20.44197396
84FLT30.44134092
85MAP4K10.43214957
86ROCK10.42514833
87PRKCE0.40892404
88IGF1R0.39777923
89EPHB20.39716046
90JAK20.39014813
91PRKCI0.38809867
92DAPK30.38034164
93PRKACG0.37590502
94MAPK70.36501728
95CSF1R0.35457003
96AKT20.33472649
97PTK2B0.32737903
98CAMK2A0.32206043
99INSR0.32102533
100PRKCG0.30703175

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049785.44073277
2Fatty acid elongation_Homo sapiens_hsa000622.60487179
3Folate biosynthesis_Homo sapiens_hsa007902.42079383
4Complement and coagulation cascades_Homo sapiens_hsa046102.29275436
5Other glycan degradation_Homo sapiens_hsa005112.05973096
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.01600681
7Oxidative phosphorylation_Homo sapiens_hsa001901.99399226
8Collecting duct acid secretion_Homo sapiens_hsa049661.97616610
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93081882
10PPAR signaling pathway_Homo sapiens_hsa033201.84657302
11Butanoate metabolism_Homo sapiens_hsa006501.76637138
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75707692
13Sulfur metabolism_Homo sapiens_hsa009201.69914568
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68614105
15Proteasome_Homo sapiens_hsa030501.67998400
16Rheumatoid arthritis_Homo sapiens_hsa053231.63549112
17Pertussis_Homo sapiens_hsa051331.61711036
18Glutathione metabolism_Homo sapiens_hsa004801.59617761
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57933589
20Arginine biosynthesis_Homo sapiens_hsa002201.52489737
21Fatty acid degradation_Homo sapiens_hsa000711.47349937
22Lysosome_Homo sapiens_hsa041421.46333328
23Tyrosine metabolism_Homo sapiens_hsa003501.43823019
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40054645
25Tryptophan metabolism_Homo sapiens_hsa003801.38066168
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32777976
27Fatty acid biosynthesis_Homo sapiens_hsa000611.32120073
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29536231
29Glycerolipid metabolism_Homo sapiens_hsa005611.27646364
30Phenylalanine metabolism_Homo sapiens_hsa003601.27550635
31Chemical carcinogenesis_Homo sapiens_hsa052041.24135246
32Vitamin B6 metabolism_Homo sapiens_hsa007501.23555228
33Parkinsons disease_Homo sapiens_hsa050121.22746249
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21560316
35Protein export_Homo sapiens_hsa030601.21188991
36beta-Alanine metabolism_Homo sapiens_hsa004101.19033197
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15544355
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.13511182
39Caffeine metabolism_Homo sapiens_hsa002321.13211680
40Fructose and mannose metabolism_Homo sapiens_hsa000511.12259619
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10040365
42TNF signaling pathway_Homo sapiens_hsa046681.09305713
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.08766324
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.07643882
45Prion diseases_Homo sapiens_hsa050201.06618918
46N-Glycan biosynthesis_Homo sapiens_hsa005101.04325572
47Legionellosis_Homo sapiens_hsa051341.03860358
48Fat digestion and absorption_Homo sapiens_hsa049751.03341458
49Alzheimers disease_Homo sapiens_hsa050100.98555869
50Peroxisome_Homo sapiens_hsa041460.98433349
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98220328
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98191406
53Malaria_Homo sapiens_hsa051440.96311815
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96197159
55Retinol metabolism_Homo sapiens_hsa008300.94298597
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92580022
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89854135
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88634348
59Galactose metabolism_Homo sapiens_hsa000520.86632401
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86133711
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86085491
62Propanoate metabolism_Homo sapiens_hsa006400.83598763
63Fatty acid metabolism_Homo sapiens_hsa012120.80592313
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80570137
65Vibrio cholerae infection_Homo sapiens_hsa051100.73753041
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73680833
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72850753
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71926038
69Nitrogen metabolism_Homo sapiens_hsa009100.70961329
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.69953323
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69749889
72Protein digestion and absorption_Homo sapiens_hsa049740.69022695
73Salmonella infection_Homo sapiens_hsa051320.68129918
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62982119
75Sulfur relay system_Homo sapiens_hsa041220.62469232
76Carbon metabolism_Homo sapiens_hsa012000.60927553
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60255807
78African trypanosomiasis_Homo sapiens_hsa051430.60189508
79Shigellosis_Homo sapiens_hsa051310.58954698
80Linoleic acid metabolism_Homo sapiens_hsa005910.57843701
81Huntingtons disease_Homo sapiens_hsa050160.56924859
82Metabolic pathways_Homo sapiens_hsa011000.56633293
83Arachidonic acid metabolism_Homo sapiens_hsa005900.56608036
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56262665
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55361497
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55224103
87Staphylococcus aureus infection_Homo sapiens_hsa051500.54721272
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53290633
89Pyruvate metabolism_Homo sapiens_hsa006200.51882991
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51462075
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.49470298
92Pentose phosphate pathway_Homo sapiens_hsa000300.49357301
93Graft-versus-host disease_Homo sapiens_hsa053320.44461227
94Osteoclast differentiation_Homo sapiens_hsa043800.40876835
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40672012
96Ovarian steroidogenesis_Homo sapiens_hsa049130.39476662
97Bile secretion_Homo sapiens_hsa049760.38910458
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38687016
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.37753694
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.37633912

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