MT1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cellular response to cadmium ion (GO:0071276)9.79240352
2epoxygenase P450 pathway (GO:0019373)6.81184351
3fat-soluble vitamin biosynthetic process (GO:0042362)5.92834265
4angiotensin maturation (GO:0002003)5.27547505
5omega-hydroxylase P450 pathway (GO:0097267)5.23488420
6positive regulation of triglyceride lipase activity (GO:0061365)4.98233944
7positive regulation of lipoprotein lipase activity (GO:0051006)4.98233944
8exogenous drug catabolic process (GO:0042738)4.94844244
9drug catabolic process (GO:0042737)4.83110487
10* response to zinc ion (GO:0010043)4.81077983
11complement activation, alternative pathway (GO:0006957)4.68615828
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59100281
13regulation of triglyceride catabolic process (GO:0010896)4.33879022
14ethanol oxidation (GO:0006069)4.32650578
15phospholipid efflux (GO:0033700)4.32534255
16drug metabolic process (GO:0017144)4.32454216
17negative regulation of cholesterol transport (GO:0032375)4.21788130
18negative regulation of sterol transport (GO:0032372)4.21788130
19urea metabolic process (GO:0019627)4.19969811
20eosinophil chemotaxis (GO:0048245)4.14632308
21regulation of macrophage chemotaxis (GO:0010758)4.13322365
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.06862857
23L-phenylalanine metabolic process (GO:0006558)4.06862857
24regulation of mononuclear cell migration (GO:0071675)4.04582249
25regulation of cholesterol esterification (GO:0010872)4.03159025
26* response to cadmium ion (GO:0046686)4.01643352
27nitrogen cycle metabolic process (GO:0071941)4.00177373
28peptide catabolic process (GO:0043171)3.99478873
29regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.95415676
30positive regulation of fatty acid biosynthetic process (GO:0045723)3.94862593
31fructose metabolic process (GO:0006000)3.93695273
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.93216332
33L-phenylalanine catabolic process (GO:0006559)3.93216332
34urea cycle (GO:0000050)3.89805992
35acute-phase response (GO:0006953)3.83063641
36plasma lipoprotein particle remodeling (GO:0034369)3.66933040
37protein-lipid complex remodeling (GO:0034368)3.66933040
38macromolecular complex remodeling (GO:0034367)3.66933040
39glycosphingolipid catabolic process (GO:0046479)3.65893202
40eosinophil migration (GO:0072677)3.65196712
41glucuronate metabolic process (GO:0019585)3.61812110
42uronic acid metabolic process (GO:0006063)3.61812110
43cellular glucuronidation (GO:0052695)3.57287114
44cholesterol efflux (GO:0033344)3.55553160
45glycolipid catabolic process (GO:0019377)3.55472455
46bile acid and bile salt transport (GO:0015721)3.53400776
47NADH metabolic process (GO:0006734)3.52372805
48intestinal absorption (GO:0050892)3.51936090
49vitamin biosynthetic process (GO:0009110)3.40063914
50very-low-density lipoprotein particle assembly (GO:0034379)3.36423006
51glyoxylate metabolic process (GO:0046487)3.34770172
52aromatic amino acid family catabolic process (GO:0009074)3.34674478
53ethanol metabolic process (GO:0006067)3.32724823
54adhesion of symbiont to host cell (GO:0044650)3.26368756
55virion attachment to host cell (GO:0019062)3.26368756
56bile acid metabolic process (GO:0008206)3.26221381
57negative regulation of myeloid cell apoptotic process (GO:0033033)3.25757814
58complement activation (GO:0006956)3.22002510
59regulation of vitamin metabolic process (GO:0030656)3.21172240
60high-density lipoprotein particle remodeling (GO:0034375)3.20745110
61regulation of protein activation cascade (GO:2000257)3.19000993
62complement activation, classical pathway (GO:0006958)3.15158442
63plasma lipoprotein particle assembly (GO:0034377)3.10829412
64regulation of fibrinolysis (GO:0051917)3.08124588
65neutrophil activation involved in immune response (GO:0002283)3.06672184
66regulation of complement activation (GO:0030449)3.06324915
67positive regulation of triglyceride metabolic process (GO:0090208)3.05408210
68low-density lipoprotein particle remodeling (GO:0034374)3.03003897
69reverse cholesterol transport (GO:0043691)3.01255638
70plasma lipoprotein particle organization (GO:0071827)3.00915216
71regulation of cholesterol homeostasis (GO:2000188)2.98185228
72protein activation cascade (GO:0072376)2.98033981
73lipoprotein metabolic process (GO:0042157)2.95208072
74positive regulation of lipid catabolic process (GO:0050996)2.94192455
75ceramide catabolic process (GO:0046514)2.92857258
76L-ascorbic acid metabolic process (GO:0019852)2.92656825
77membrane lipid catabolic process (GO:0046466)2.91406229
78fibrinolysis (GO:0042730)2.90556549
79triglyceride homeostasis (GO:0070328)2.88019212
80acylglycerol homeostasis (GO:0055090)2.88019212
81protein-lipid complex subunit organization (GO:0071825)2.87750656
82apoptotic cell clearance (GO:0043277)2.86793220
83regulation of apoptotic cell clearance (GO:2000425)2.86238838
84protein-lipid complex assembly (GO:0065005)2.85592809
85regulation of guanylate cyclase activity (GO:0031282)2.84284246
86indole-containing compound catabolic process (GO:0042436)2.82637275
87indolalkylamine catabolic process (GO:0046218)2.82637275
88tryptophan catabolic process (GO:0006569)2.82637275
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82374017
90hormone catabolic process (GO:0042447)2.82013256
91adhesion of symbiont to host (GO:0044406)2.80869044
92acute inflammatory response (GO:0002526)2.79561890
93sphingolipid catabolic process (GO:0030149)2.78989214
94cellular response to ethanol (GO:0071361)2.77803433
95negative regulation of hemostasis (GO:1900047)2.75741742
96negative regulation of blood coagulation (GO:0030195)2.75741742
97bile acid biosynthetic process (GO:0006699)2.73711384
98alkaloid metabolic process (GO:0009820)2.72426384
99negative regulation of coagulation (GO:0050819)2.72422965
100* cellular response to zinc ion (GO:0071294)12.6502014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.19386458
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.79218210
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.72719936
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.56873965
5* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.44821036
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35593990
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00897583
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99686797
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.91388592
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.83715666
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.73130673
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.62370830
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.32864119
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17561878
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17045073
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13665518
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.09478914
18LXR_22292898_ChIP-Seq_THP-1_Human2.07354671
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98416876
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92553188
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.89198844
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88757659
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.88374574
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85683108
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81944504
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74204004
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62944001
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61051173
29CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59913014
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59563153
31CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53213721
32BCOR_27268052_Chip-Seq_Bcells_Human1.51745785
33* SOX2_20726797_ChIP-Seq_SW620_Human1.43589982
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39225184
35BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.38814977
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38063946
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.35753156
38VDR_24763502_ChIP-Seq_THP-1_Human1.33950850
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33612756
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.33390822
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.32817323
42BCL6_27268052_Chip-Seq_Bcells_Human1.32811086
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31837012
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31122345
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30443689
46GATA4_25053715_ChIP-Seq_YYC3_Human1.29996834
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28370421
48SA1_27219007_Chip-Seq_Bcells_Human1.27860660
49GATA6_25053715_ChIP-Seq_YYC3_Human1.23942683
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22104751
51SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20622698
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18664619
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16954301
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16346671
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15844290
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.15572276
57GATA1_22025678_ChIP-Seq_K562_Human1.13572579
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12133105
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10158713
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.09935573
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09401070
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08892178
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08483981
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08199731
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07938519
66RACK7_27058665_Chip-Seq_MCF-7_Human1.07059366
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06433798
68OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06399455
69STAT1_20625510_ChIP-Seq_HELA_Human1.05546069
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05084991
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04793307
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.04020216
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03102794
74EGR1_19032775_ChIP-ChIP_M12_Human1.00858154
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00377140
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00173450
77SPI1_23547873_ChIP-Seq_NB4_Human0.98003060
78VDR_24787735_ChIP-Seq_THP-1_Human0.97659654
79GATA1_19941826_ChIP-Seq_K562_Human0.96985595
80SPI1_23127762_ChIP-Seq_K562_Human0.96815324
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96497439
82CLOCK_20551151_ChIP-Seq_293T_Human0.95249761
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94784374
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94370228
85TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93334383
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92926382
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92795860
88RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92716675
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92440836
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91834310
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.91371588
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91005129
93P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90476768
94FOXA2_19822575_ChIP-Seq_HepG2_Human0.89451484
95VDR_21846776_ChIP-Seq_THP-1_Human0.89421568
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88631057
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88236324
98PHF8_20622854_ChIP-Seq_HELA_Human0.87920327
99* YY1_22570637_ChIP-Seq_MALME-3M_Human0.87766614
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86438818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.33645939
2MP0005360_urolithiasis5.03376542
3MP0009840_abnormal_foam_cell4.88656474
4MP0005365_abnormal_bile_salt4.04582130
5MP0003195_calcinosis3.52460175
6MP0005085_abnormal_gallbladder_physiolo3.48071318
7MP0003806_abnormal_nucleotide_metabolis3.02650611
8MP0001666_abnormal_nutrient_absorption3.01369023
9MP0003191_abnormal_cellular_cholesterol2.92098072
10MP0009785_altered_susceptibility_to2.85653327
11MP0008875_abnormal_xenobiotic_pharmacok2.77940154
12MP0004019_abnormal_vitamin_homeostasis2.54912018
13MP0003436_decreased_susceptibility_to2.46018521
14MP0009764_decreased_sensitivity_to2.20799709
15MP0005058_abnormal_lysosome_morphology2.15991146
16MP0002148_abnormal_hypersensitivity_rea2.12049132
17MP0010329_abnormal_lipoprotein_level2.05138160
18MP0002837_dystrophic_cardiac_calcinosis2.02010159
19MP0002138_abnormal_hepatobiliary_system2.00148828
20MP0003183_abnormal_peptide_metabolism1.89956321
21MP0005332_abnormal_amino_acid1.88778768
22MP0003075_altered_response_to1.88349358
23MP0009278_abnormal_bone_marrow1.85204885
24MP0000343_altered_response_to1.82305511
25MP0005167_abnormal_blood-brain_barrier1.79854401
26MP0010155_abnormal_intestine_physiology1.74992841
27MP0000604_amyloidosis1.73409576
28MP0002419_abnormal_innate_immunity1.71385352
29MP0005166_decreased_susceptibility_to1.67592273
30MP0005025_abnormal_response_to1.56913962
31MP0002254_reproductive_system_inflammat1.53179199
32MP0006082_CNS_inflammation1.51375104
33MP0001853_heart_inflammation1.49829730
34MP0001845_abnormal_inflammatory_respons1.43421674
35MP0008469_abnormal_protein_level1.42017378
36MP0001764_abnormal_homeostasis1.40713693
37MP0001533_abnormal_skeleton_physiology1.38651588
38MP0003303_peritoneal_inflammation1.37438078
39MP0003868_abnormal_feces_composition1.35609942
40MP0008260_abnormal_autophagy1.33825327
41MP0005387_immune_system_phenotype1.31686064
42MP0001790_abnormal_immune_system1.31686064
43MP0002998_abnormal_bone_remodeling1.30612228
44MP0000609_abnormal_liver_physiology1.29971332
45MP0009643_abnormal_urine_homeostasis1.25418160
46MP0002118_abnormal_lipid_homeostasis1.23074307
47MP0005000_abnormal_immune_tolerance1.21715659
48MP0003252_abnormal_bile_duct1.20262358
49MP0003172_abnormal_lysosome_physiology1.19880977
50MP0004264_abnormal_extraembryonic_tissu1.16655237
51MP0003300_gastrointestinal_ulcer1.16050876
52MP0001545_abnormal_hematopoietic_system1.12944074
53MP0005397_hematopoietic_system_phenotyp1.12944074
54MP0009765_abnormal_xenobiotic_induced1.12757398
55MP0005319_abnormal_enzyme/_coenzyme1.12497411
56MP0003690_abnormal_glial_cell1.08394369
57MP0005670_abnormal_white_adipose1.07746677
58MP0004510_myositis1.07382991
59MP0005636_abnormal_mineral_homeostasis1.06627534
60MP0010234_abnormal_vibrissa_follicle1.06276986
61MP0009763_increased_sensitivity_to1.04587335
62MP0005584_abnormal_enzyme/coenzyme_acti1.03565022
63MP0005023_abnormal_wound_healing1.01822044
64MP0003186_abnormal_redox_activity1.01226652
65MP0003329_amyloid_beta_deposits0.96092901
66MP0003453_abnormal_keratinocyte_physiol0.94605252
67MP0003448_altered_tumor_morphology0.94427806
68MP0005671_abnormal_response_to0.93085508
69MP0005451_abnormal_body_composition0.92855680
70MP0002452_abnormal_antigen_presenting0.91405901
71MP0001849_ear_inflammation0.88058785
72MP0000858_altered_metastatic_potential0.86977966
73MP0000678_abnormal_parathyroid_gland0.85720133
74MP0001835_abnormal_antigen_presentation0.85308150
75MP0008874_decreased_physiological_sensi0.85053484
76MP0005464_abnormal_platelet_physiology0.84334482
77MP0003656_abnormal_erythrocyte_physiolo0.84253297
78MP0002723_abnormal_immune_serum0.81750403
79MP0000249_abnormal_blood_vessel0.80038120
80MP0000685_abnormal_immune_system0.76354064
81MP0000920_abnormal_myelination0.76104890
82MP0003638_abnormal_response/metabolism_0.75483230
83MP0009333_abnormal_splenocyte_physiolog0.75315771
84MP0003879_abnormal_hair_cell0.74518597
85MP0001663_abnormal_digestive_system0.72603901
86MP0002136_abnormal_kidney_physiology0.72446994
87MP0009642_abnormal_blood_homeostasis0.72177234
88MP0005310_abnormal_salivary_gland0.71963714
89MP0003828_pulmonary_edema0.71959891
90MP0001800_abnormal_humoral_immune0.71935859
91MP0003724_increased_susceptibility_to0.70109290
92MP0003878_abnormal_ear_physiology0.68664676
93MP0005377_hearing/vestibular/ear_phenot0.68664676
94MP0002896_abnormal_bone_mineralization0.68468518
95MP0001756_abnormal_urination0.66566622
96MP0004947_skin_inflammation0.66545048
97MP0001819_abnormal_immune_cell0.66539158
98MP0004043_abnormal_pH_regulation0.66167131
99MP0004883_abnormal_blood_vessel0.64974693
100MP0000490_abnormal_crypts_of0.64816448

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.65197641
2Complement deficiency (HP:0004431)6.17708877
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.72099686
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.41352397
5Abnormality of complement system (HP:0005339)5.08175720
6Malnutrition (HP:0004395)4.96231841
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.75227810
8Xanthomatosis (HP:0000991)4.75002423
9Recurrent gram-negative bacterial infections (HP:0005420)4.66641721
10Glomerulonephritis (HP:0000099)4.59419763
11Hypobetalipoproteinemia (HP:0003563)4.14832399
12Hydroxyprolinuria (HP:0003080)3.72998404
13Abnormality of proline metabolism (HP:0010907)3.72998404
14Prolonged partial thromboplastin time (HP:0003645)3.62782220
15Abnormality of pyrimidine metabolism (HP:0004353)3.60390953
16Abnormality of liposaccharide metabolism (HP:0010968)3.55421522
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.55421522
18Abnormality of glycolipid metabolism (HP:0010969)3.55421522
19Deep venous thrombosis (HP:0002625)3.50402977
20Eczematoid dermatitis (HP:0000976)3.47113967
21Fat malabsorption (HP:0002630)3.38329638
22Metaphyseal irregularity (HP:0003025)3.15871979
23Abnormality of macrophages (HP:0004311)3.12802129
24Steatorrhea (HP:0002570)3.10621195
25Nephritis (HP:0000123)3.05259357
26Nausea (HP:0002018)3.04276763
27Recurrent abscess formation (HP:0002722)3.00521503
28Generalized aminoaciduria (HP:0002909)2.94502691
29Widely patent fontanelles and sutures (HP:0004492)2.88644567
30Hypophosphatemia (HP:0002148)2.85945810
31Increased serum ferritin (HP:0003281)2.84515467
32Recurrent bacterial skin infections (HP:0005406)2.76263233
33Joint hemorrhage (HP:0005261)2.66310488
34Abnormal hemoglobin (HP:0011902)2.63288533
35Conjugated hyperbilirubinemia (HP:0002908)2.63236667
36Vacuolated lymphocytes (HP:0001922)2.62658691
37Hyperlipoproteinemia (HP:0010980)2.62017123
38Hypolipoproteinemia (HP:0010981)2.56343263
39Increased cerebral lipofuscin (HP:0011813)2.53392352
40Abnormality of iron homeostasis (HP:0011031)2.50550295
41Protuberant abdomen (HP:0001538)2.47944185
42Intrahepatic cholestasis (HP:0001406)2.44734208
43Thin bony cortex (HP:0002753)2.41166528
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.40132425
45Symptomatic seizures (HP:0011145)2.39654664
46Hyperammonemia (HP:0001987)2.38997828
47Retinal atrophy (HP:0001105)2.36972722
48Delayed epiphyseal ossification (HP:0002663)2.36945277
49Abnormality of nucleobase metabolism (HP:0010932)2.35701446
50Purpura (HP:0000979)2.34523071
51Abnormality of glycine metabolism (HP:0010895)2.31913876
52Abnormality of serine family amino acid metabolism (HP:0010894)2.31913876
53Loss of speech (HP:0002371)2.31702175
54Pancreatitis (HP:0001733)2.31429193
55Amyloidosis (HP:0011034)2.30828047
56Hemorrhage of the eye (HP:0011885)2.30468644
57Abnormal enzyme/coenzyme activity (HP:0012379)2.30167607
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25419175
59Abnormality of alkaline phosphatase activity (HP:0004379)2.25259018
60Elevated alkaline phosphatase (HP:0003155)2.25197419
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.25036422
62Hyperglycinuria (HP:0003108)2.24343285
63Metabolic alkalosis (HP:0200114)2.23193220
64Alkalosis (HP:0001948)2.21489076
65Bone pain (HP:0002653)2.20019411
66Abnormality of vitamin metabolism (HP:0100508)2.19775463
67Dysostosis multiplex (HP:0000943)2.18508832
68Abnormality of transition element cation homeostasis (HP:0011030)2.18228777
69Visceral angiomatosis (HP:0100761)2.16965236
70Confusion (HP:0001289)2.16807445
71Mutism (HP:0002300)2.16045341
72Petechiae (HP:0000967)2.14902102
73Myocardial infarction (HP:0001658)2.14522941
74Abnormality of vitamin B metabolism (HP:0004340)2.11755703
75Gingivitis (HP:0000230)2.10741030
76Neurofibrillary tangles (HP:0002185)2.09305529
77Abdominal distention (HP:0003270)2.08244765
78Spontaneous hematomas (HP:0007420)2.07778684
79Irritability (HP:0000737)2.07609577
80Pathologic fracture (HP:0002756)2.06693549
81Rickets (HP:0002748)2.06489734
82Premature loss of primary teeth (HP:0006323)2.05860605
83Ileus (HP:0002595)2.04977690
84Abnormality of urine glucose concentration (HP:0011016)2.04475313
85Glycosuria (HP:0003076)2.04475313
86Abnormality of sulfur amino acid metabolism (HP:0004339)2.04391562
87Nephrolithiasis (HP:0000787)2.03044814
88Hematochezia (HP:0002573)2.02644698
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01411677
90Bone cyst (HP:0012062)2.00628396
91Axonal loss (HP:0003447)1.98828545
92Hemangiomatosis (HP:0007461)1.94749062
93Abnormality of polysaccharide metabolism (HP:0011012)1.93334193
94Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93334193
95Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93334193
96Chronic diarrhea (HP:0002028)1.91805448
97Abnormality of the costochondral junction (HP:0000919)1.90507664
98Hyperactive renin-angiotensin system (HP:0000841)1.89916231
99Epidermoid cyst (HP:0200040)1.88975326
100Hypoalphalipoproteinemia (HP:0003233)1.88899110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.16169115
2ERN14.29361839
3NME23.76340142
4TGFBR23.00397375
5BLK2.86328938
6RIPK42.72418635
7DDR22.66874448
8MATK2.60361740
9PRKG22.48480270
10TYK22.35498850
11IRAK32.16597430
12TESK12.11197282
13ABL21.92857069
14RIPK11.90518967
15CSK1.84585789
16FGR1.81967479
17MAP3K111.79754613
18MAP3K31.79655718
19TESK21.64866597
20MAP3K131.58014324
21PDK21.54005841
22CSF1R1.49746254
23OXSR11.44701723
24MAP3K121.44124111
25LMTK21.33048484
26CDC42BPA1.30156833
27MAP3K11.29334774
28TAOK11.28415196
29LIMK11.27856531
30MAP3K141.22198313
31TAOK21.22087732
32EPHB21.21617748
33MAP2K61.20769017
34GRK71.19938223
35TBK11.17530924
36PRPF4B1.12349948
37ARAF1.11947604
38FGFR41.10091652
39PBK1.08836738
40MAP4K11.07991195
41TGFBR11.07391417
42DAPK21.02916274
43PAK41.02638221
44PDPK10.94942397
45LYN0.94492202
46MST1R0.92614937
47KSR20.92338098
48MAP3K20.87843787
49IKBKB0.84850946
50CAMKK20.84576917
51MST40.84496646
52PRKAA20.84389802
53IKBKE0.80452992
54ADRBK20.79034847
55KDR0.73383279
56IRAK40.72907370
57BCKDK0.70553472
58PRKACG0.70235329
59TYRO30.70050878
60ZAP700.69575680
61EPHA20.66602620
62CAMK1D0.66212938
63BMX0.65242015
64RPS6KL10.64728749
65RPS6KC10.64728749
66MAP2K30.64268513
67TNIK0.61449544
68RPS6KA20.60859178
69PTK60.59894994
70JAK30.56033322
71PDK10.51742129
72MYLK0.51157911
73RPS6KA60.50281579
74MAP3K80.49741467
75PRKCA0.49266498
76PRKCD0.47835954
77JAK10.45879410
78JAK20.45740837
79SMG10.45458814
80SRC0.43377361
81STK160.42769447
82PDGFRA0.42466153
83GRK60.41826362
84SYK0.38302972
85PRKCZ0.37390702
86IGF1R0.37111385
87EPHA30.37057330
88EEF2K0.36933207
89MAPK120.36429907
90CAMK2G0.35587691
91MAP2K40.35091576
92LCK0.33623110
93STK240.33352990
94PRKCG0.33179593
95MAPKAPK30.31568570
96BRAF0.31511726
97MAP2K20.31149106
98ALK0.29899158
99KIT0.29564417
100FYN0.29534395

Predicted pathways (KEGG)

RankGene SetZ-score
1* Mineral absorption_Homo sapiens_hsa049784.00272847
2Caffeine metabolism_Homo sapiens_hsa002323.19522801
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.95789619
4Complement and coagulation cascades_Homo sapiens_hsa046102.57248728
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50333209
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.44750641
7Fat digestion and absorption_Homo sapiens_hsa049752.44203183
8Retinol metabolism_Homo sapiens_hsa008302.42814672
9Chemical carcinogenesis_Homo sapiens_hsa052042.26905627
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.26738384
11Histidine metabolism_Homo sapiens_hsa003402.26328115
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23935847
13Arginine biosynthesis_Homo sapiens_hsa002202.17743365
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14806075
15Staphylococcus aureus infection_Homo sapiens_hsa051502.14161090
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03748277
17Vitamin digestion and absorption_Homo sapiens_hsa049772.00055601
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97371704
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.93554133
20Fatty acid degradation_Homo sapiens_hsa000711.90454692
21PPAR signaling pathway_Homo sapiens_hsa033201.80811940
22Renin-angiotensin system_Homo sapiens_hsa046141.78399939
23Tryptophan metabolism_Homo sapiens_hsa003801.75039424
24Phenylalanine metabolism_Homo sapiens_hsa003601.73353773
25Sulfur metabolism_Homo sapiens_hsa009201.69896935
26Linoleic acid metabolism_Homo sapiens_hsa005911.67139829
27Starch and sucrose metabolism_Homo sapiens_hsa005001.65443970
28Other glycan degradation_Homo sapiens_hsa005111.54551617
29Fructose and mannose metabolism_Homo sapiens_hsa000511.53565195
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.51877589
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48193929
32Tyrosine metabolism_Homo sapiens_hsa003501.43899350
33Arachidonic acid metabolism_Homo sapiens_hsa005901.38123268
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36711040
35Rheumatoid arthritis_Homo sapiens_hsa053231.35718199
36Bile secretion_Homo sapiens_hsa049761.35260982
37Prion diseases_Homo sapiens_hsa050201.33849991
38Pertussis_Homo sapiens_hsa051331.31328925
39Galactose metabolism_Homo sapiens_hsa000521.31111990
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25147641
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17434166
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13125155
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12485770
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11906092
45Lysosome_Homo sapiens_hsa041421.09665051
46Protein digestion and absorption_Homo sapiens_hsa049741.07552835
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00075585
48Arginine and proline metabolism_Homo sapiens_hsa003300.96672550
49Glutathione metabolism_Homo sapiens_hsa004800.82224012
50Glycerolipid metabolism_Homo sapiens_hsa005610.79751706
51Vitamin B6 metabolism_Homo sapiens_hsa007500.78526312
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.75980997
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74552543
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73784609
55Legionellosis_Homo sapiens_hsa051340.70967295
56Biosynthesis of amino acids_Homo sapiens_hsa012300.70735714
57Carbon metabolism_Homo sapiens_hsa012000.70215982
58Collecting duct acid secretion_Homo sapiens_hsa049660.69905239
59TNF signaling pathway_Homo sapiens_hsa046680.69221372
60Peroxisome_Homo sapiens_hsa041460.68809619
61Pentose phosphate pathway_Homo sapiens_hsa000300.68198650
62Asthma_Homo sapiens_hsa053100.66394587
63Folate biosynthesis_Homo sapiens_hsa007900.64680631
64Tuberculosis_Homo sapiens_hsa051520.63840458
65Osteoclast differentiation_Homo sapiens_hsa043800.63618555
66Phagosome_Homo sapiens_hsa041450.62668582
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60869269
68Leishmaniasis_Homo sapiens_hsa051400.59647260
69Butanoate metabolism_Homo sapiens_hsa006500.59167837
70Pyruvate metabolism_Homo sapiens_hsa006200.59107268
71Salmonella infection_Homo sapiens_hsa051320.58144299
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57387954
73Malaria_Homo sapiens_hsa051440.55047078
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.54654598
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51724695
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51366375
77beta-Alanine metabolism_Homo sapiens_hsa004100.49726518
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48890392
79Amoebiasis_Homo sapiens_hsa051460.44008478
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.43405180
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42686872
82Ether lipid metabolism_Homo sapiens_hsa005650.41561707
83Chemokine signaling pathway_Homo sapiens_hsa040620.41017679
84Pancreatic secretion_Homo sapiens_hsa049720.40062582
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38752387
86Sphingolipid metabolism_Homo sapiens_hsa006000.37245140
87Graft-versus-host disease_Homo sapiens_hsa053320.35021584
88Hematopoietic cell lineage_Homo sapiens_hsa046400.34691281
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34644034
90Sulfur relay system_Homo sapiens_hsa041220.34109638
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.34045744
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33227009
93Bladder cancer_Homo sapiens_hsa052190.32467873
94Allograft rejection_Homo sapiens_hsa053300.32278078
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31871351
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.31679861
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31021074
98Metabolic pathways_Homo sapiens_hsa011000.30350129
99African trypanosomiasis_Homo sapiens_hsa051430.27186913
100Type I diabetes mellitus_Homo sapiens_hsa049400.23137260

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