MT1F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cellular response to cadmium ion (GO:0071276)9.01716125
2epoxygenase P450 pathway (GO:0019373)5.78555875
3fat-soluble vitamin biosynthetic process (GO:0042362)5.40997267
4L-phenylalanine metabolic process (GO:0006558)4.87114848
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.87114848
6L-phenylalanine catabolic process (GO:0006559)4.81044603
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81044603
8* response to zinc ion (GO:0010043)4.76186060
9omega-hydroxylase P450 pathway (GO:0097267)4.56598789
10angiotensin maturation (GO:0002003)4.38483222
11eosinophil chemotaxis (GO:0048245)4.26671852
12positive regulation of triglyceride lipase activity (GO:0061365)4.11225546
13positive regulation of lipoprotein lipase activity (GO:0051006)4.11225546
14regulation of mononuclear cell migration (GO:0071675)4.03683849
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.93199371
16vitamin biosynthetic process (GO:0009110)3.91491154
17aromatic amino acid family catabolic process (GO:0009074)3.88880913
18exogenous drug catabolic process (GO:0042738)3.87503863
19drug catabolic process (GO:0042737)3.84870142
20eosinophil migration (GO:0072677)3.75302471
21regulation of cholesterol esterification (GO:0010872)3.73712365
22drug metabolic process (GO:0017144)3.65613320
23phospholipid efflux (GO:0033700)3.64086120
24ethanol oxidation (GO:0006069)3.60208902
25* response to cadmium ion (GO:0046686)3.59375127
26regulation of macrophage chemotaxis (GO:0010758)3.51023454
27complement activation, alternative pathway (GO:0006957)3.49593752
28fructose metabolic process (GO:0006000)3.47290946
29regulation of triglyceride catabolic process (GO:0010896)3.40086797
30positive regulation of fatty acid biosynthetic process (GO:0045723)3.37534194
31acute-phase response (GO:0006953)3.33820086
32macromolecular complex remodeling (GO:0034367)3.24268449
33plasma lipoprotein particle remodeling (GO:0034369)3.24268449
34protein-lipid complex remodeling (GO:0034368)3.24268449
35negative regulation of cholesterol transport (GO:0032375)3.21589077
36negative regulation of sterol transport (GO:0032372)3.21589077
37L-ascorbic acid metabolic process (GO:0019852)3.20738872
38oligosaccharide catabolic process (GO:0009313)3.19270300
39high-density lipoprotein particle remodeling (GO:0034375)3.18001032
40cholesterol efflux (GO:0033344)3.12863757
41reverse cholesterol transport (GO:0043691)3.11675114
42acylglycerol homeostasis (GO:0055090)3.09974388
43triglyceride homeostasis (GO:0070328)3.09974388
44tryptophan catabolic process (GO:0006569)3.06957633
45indole-containing compound catabolic process (GO:0042436)3.06957633
46indolalkylamine catabolic process (GO:0046218)3.06957633
47xenobiotic catabolic process (GO:0042178)3.04440576
48regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.95263720
49glycosphingolipid catabolic process (GO:0046479)2.94776687
50urea metabolic process (GO:0019627)2.93210925
51uronic acid metabolic process (GO:0006063)2.89264391
52glucuronate metabolic process (GO:0019585)2.89264391
53phenylpropanoid metabolic process (GO:0009698)2.88523071
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.88434471
55nitrogen cycle metabolic process (GO:0071941)2.86990892
56vitamin D metabolic process (GO:0042359)2.85495725
57peptide hormone processing (GO:0016486)2.83287322
58glycolipid catabolic process (GO:0019377)2.82216340
59peptide catabolic process (GO:0043171)2.80310427
60glyoxylate metabolic process (GO:0046487)2.76921107
61cellular biogenic amine catabolic process (GO:0042402)2.74602168
62amine catabolic process (GO:0009310)2.74602168
63bile acid metabolic process (GO:0008206)2.73822346
64urea cycle (GO:0000050)2.72449692
65regulation of guanylate cyclase activity (GO:0031282)2.72107302
66ethanol metabolic process (GO:0006067)2.70583011
67cellular glucuronidation (GO:0052695)2.69904531
68bile acid and bile salt transport (GO:0015721)2.67225983
69membrane lipid catabolic process (GO:0046466)2.63820070
70hydrogen peroxide biosynthetic process (GO:0050665)2.61087160
71bile acid biosynthetic process (GO:0006699)2.60561100
72virion attachment to host cell (GO:0019062)2.59987540
73adhesion of symbiont to host cell (GO:0044650)2.59987540
74low-density lipoprotein particle remodeling (GO:0034374)2.59701309
75NADH metabolic process (GO:0006734)2.58832109
76positive regulation of cellular amine metabolic process (GO:0033240)2.58680571
77sphingolipid catabolic process (GO:0030149)2.58486817
78L-alpha-amino acid transmembrane transport (GO:1902475)2.56287190
79heme transport (GO:0015886)2.55079793
80regulation of fibrinolysis (GO:0051917)2.53999967
81fat-soluble vitamin metabolic process (GO:0006775)2.51604252
82regulation of cholesterol homeostasis (GO:2000188)2.51307186
83plasma lipoprotein particle organization (GO:0071827)2.50633969
84acute inflammatory response (GO:0002526)2.49687123
85positive regulation of triglyceride metabolic process (GO:0090208)2.48089977
86very-low-density lipoprotein particle assembly (GO:0034379)2.44909056
87lipoprotein metabolic process (GO:0042157)2.43600848
88aromatic amino acid family metabolic process (GO:0009072)2.43262024
89regulation of bile acid biosynthetic process (GO:0070857)2.43107654
90complement activation (GO:0006956)2.42449456
91water-soluble vitamin biosynthetic process (GO:0042364)2.41985041
92intestinal absorption (GO:0050892)2.41873621
93ceramide catabolic process (GO:0046514)2.41836332
94regulation of oxidative phosphorylation (GO:0002082)2.41680016
95protein-lipid complex subunit organization (GO:0071825)2.41174438
96regulation of protein activation cascade (GO:2000257)2.39889271
97cellular ketone body metabolic process (GO:0046950)2.39368320
98complement activation, classical pathway (GO:0006958)2.37820823
99positive regulation of icosanoid secretion (GO:0032305)2.37805868
100* cellular response to zinc ion (GO:0071294)12.2330107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.49292307
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.43556044
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.19323744
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.02118939
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96417308
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89826365
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.78728712
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.72367464
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.71681913
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.69601667
11* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64236537
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.63191498
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38819746
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33111279
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.28382670
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.27718963
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23870493
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13380091
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.01344835
20HTT_18923047_ChIP-ChIP_STHdh_Human1.76464142
21* SOX2_20726797_ChIP-Seq_SW620_Human1.73952649
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.72335514
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69819453
24BCOR_27268052_Chip-Seq_Bcells_Human1.55567572
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55382005
26LXR_22292898_ChIP-Seq_THP-1_Human1.53630391
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51376794
28BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.50423262
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50234206
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42576987
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41952937
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37286239
33GATA4_25053715_ChIP-Seq_YYC3_Human1.36722333
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35084984
35MYC_19829295_ChIP-Seq_ESCs_Human1.35081724
36STAT1_20625510_ChIP-Seq_HELA_Human1.30136824
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27263887
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26355485
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25106061
40BCL6_27268052_Chip-Seq_Bcells_Human1.21161195
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20121469
42SA1_27219007_Chip-Seq_Bcells_Human1.19914488
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19778906
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19710405
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16975000
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16677293
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16296403
48TAF2_19829295_ChIP-Seq_ESCs_Human1.15037503
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13848652
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12824643
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.12694649
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11630261
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10170749
54NANOG_20526341_ChIP-Seq_ESCs_Human1.08253406
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08231709
56AR_20517297_ChIP-Seq_VCAP_Human1.07950604
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07688995
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.06952567
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04821485
60CTCF_20526341_ChIP-Seq_ESCs_Human1.04728871
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.04115694
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02148971
63GATA3_21867929_ChIP-Seq_CD8_Mouse1.01940786
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01040520
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00371401
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98833928
67TRIM28_21343339_ChIP-Seq_HEK293_Human0.97960895
68ELF1_20517297_ChIP-Seq_JURKAT_Human0.97724185
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97447215
70CBP_21632823_ChIP-Seq_H3396_Human0.96210525
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95692409
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95453106
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94221533
74ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92676973
75PHF8_20622854_ChIP-Seq_HELA_Human0.92328975
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92133859
77P300_27268052_Chip-Seq_Bcells_Human0.91597946
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90797929
79* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90776520
80SOX2_21211035_ChIP-Seq_LN229_Human0.90180169
81ERG_20517297_ChIP-Seq_VCAP_Human0.89636346
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89517452
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89269450
84SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87942062
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86928117
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.86589440
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86589440
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85667392
89OCT4_20526341_ChIP-Seq_ESCs_Human0.85484752
90E2F1_20622854_ChIP-Seq_HELA_Human0.85247210
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84623746
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.84603081
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83875721
94ERA_21632823_ChIP-Seq_H3396_Human0.83342617
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83160385
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80975962
97CTCF_27219007_Chip-Seq_Bcells_Human0.79881591
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79342881
99GATA6_25053715_ChIP-Seq_YYC3_Human0.79290459
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79240313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.81149998
2MP0009840_abnormal_foam_cell4.20842538
3MP0003195_calcinosis4.13671573
4MP0005360_urolithiasis3.82808409
5MP0005365_abnormal_bile_salt3.66575996
6MP0005085_abnormal_gallbladder_physiolo3.10267148
7MP0004019_abnormal_vitamin_homeostasis2.93539435
8MP0003806_abnormal_nucleotide_metabolis2.88260315
9MP0009785_altered_susceptibility_to2.84177556
10MP0002837_dystrophic_cardiac_calcinosis2.70209130
11MP0001666_abnormal_nutrient_absorption2.52706773
12MP0008875_abnormal_xenobiotic_pharmacok2.51668090
13MP0005058_abnormal_lysosome_morphology2.25950191
14MP0010329_abnormal_lipoprotein_level2.17905855
15MP0005332_abnormal_amino_acid2.16132467
16MP0002138_abnormal_hepatobiliary_system2.07101950
17MP0003075_altered_response_to2.05826395
18MP0002148_abnormal_hypersensitivity_rea1.97578555
19MP0003879_abnormal_hair_cell1.90173212
20MP0006082_CNS_inflammation1.83756322
21MP0003191_abnormal_cellular_cholesterol1.80659562
22MP0003183_abnormal_peptide_metabolism1.79279116
23MP0005166_decreased_susceptibility_to1.76334613
24MP0003172_abnormal_lysosome_physiology1.71222588
25MP0009764_decreased_sensitivity_to1.67835330
26MP0004510_myositis1.65841683
27MP0003436_decreased_susceptibility_to1.64277599
28MP0005167_abnormal_blood-brain_barrier1.63670403
29MP0003011_delayed_dark_adaptation1.63248858
30MP0001764_abnormal_homeostasis1.54579345
31MP0000343_altered_response_to1.51208024
32MP0002909_abnormal_adrenal_gland1.48964072
33MP0009643_abnormal_urine_homeostasis1.47850402
34MP0002876_abnormal_thyroid_physiology1.46646808
35MP0005025_abnormal_response_to1.46538870
36MP0001845_abnormal_inflammatory_respons1.42889680
37MP0002254_reproductive_system_inflammat1.39764006
38MP0005636_abnormal_mineral_homeostasis1.39640962
39MP0008469_abnormal_protein_level1.39235254
40MP0005671_abnormal_response_to1.36638825
41MP0010155_abnormal_intestine_physiology1.34604701
42MP0002419_abnormal_innate_immunity1.34493827
43MP0003690_abnormal_glial_cell1.31299150
44MP0010386_abnormal_urinary_bladder1.31007607
45MP0002118_abnormal_lipid_homeostasis1.30939601
46MP0002277_abnormal_respiratory_mucosa1.30117353
47MP0000604_amyloidosis1.27281020
48MP0001756_abnormal_urination1.26979291
49MP0002693_abnormal_pancreas_physiology1.24588296
50MP0001853_heart_inflammation1.21407099
51MP0003252_abnormal_bile_duct1.17197936
52MP0010234_abnormal_vibrissa_follicle1.14688946
53MP0003186_abnormal_redox_activity1.13885797
54MP0005387_immune_system_phenotype1.13217546
55MP0001790_abnormal_immune_system1.13217546
56MP0005000_abnormal_immune_tolerance1.12913364
57MP0000609_abnormal_liver_physiology1.08456563
58MP0005379_endocrine/exocrine_gland_phen1.07354079
59MP0005319_abnormal_enzyme/_coenzyme1.07239574
60MP0001533_abnormal_skeleton_physiology1.05994827
61MP0005584_abnormal_enzyme/coenzyme_acti1.04905459
62MP0003868_abnormal_feces_composition1.02545883
63MP0005535_abnormal_body_temperature1.00220496
64MP0001765_abnormal_ion_homeostasis1.00109593
65MP0006036_abnormal_mitochondrial_physio0.98910848
66MP0004043_abnormal_pH_regulation0.97823384
67MP0000920_abnormal_myelination0.97384818
68MP0005448_abnormal_energy_balance0.96173160
69MP0002078_abnormal_glucose_homeostasis0.94456385
70MP0002998_abnormal_bone_remodeling0.93008026
71MP0005310_abnormal_salivary_gland0.88983386
72MP0003300_gastrointestinal_ulcer0.88956381
73MP0003638_abnormal_response/metabolism_0.88027030
74MP0001485_abnormal_pinna_reflex0.84775255
75MP0009642_abnormal_blood_homeostasis0.82329487
76MP0003866_abnormal_defecation0.82321739
77MP0003633_abnormal_nervous_system0.82172513
78MP0005670_abnormal_white_adipose0.81937347
79MP0009333_abnormal_splenocyte_physiolog0.81856977
80MP0001501_abnormal_sleep_pattern0.81353392
81MP0002136_abnormal_kidney_physiology0.80425480
82MP0009780_abnormal_chondrocyte_physiolo0.79479535
83MP0000685_abnormal_immune_system0.78997855
84MP0009763_increased_sensitivity_to0.78013600
85MP0004264_abnormal_extraembryonic_tissu0.75151079
86MP0009765_abnormal_xenobiotic_induced0.73301725
87MP0002090_abnormal_vision0.73261443
88MP0002723_abnormal_immune_serum0.72804238
89MP0009379_abnormal_foot_pigmentation0.71763591
90MP0002452_abnormal_antigen_presenting0.71566875
91MP0003953_abnormal_hormone_level0.71231680
92MP0001835_abnormal_antigen_presentation0.70596130
93MP0001944_abnormal_pancreas_morphology0.70575138
94MP0008004_abnormal_stomach_pH0.70354287
95MP0008874_decreased_physiological_sensi0.69042153
96MP0002064_seizures0.65972321
97MP0008872_abnormal_physiological_respon0.65558411
98MP0003303_peritoneal_inflammation0.64447931
99MP0002163_abnormal_gland_morphology0.62776290
100MP0003283_abnormal_digestive_organ0.62530562

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.53677610
2Systemic lupus erythematosus (HP:0002725)5.28523772
3Complement deficiency (HP:0004431)4.38191974
4Abnormality of glutamine family amino acid metabolism (HP:0010902)4.31980446
5Xanthomatosis (HP:0000991)3.88248994
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.86439231
7Malnutrition (HP:0004395)3.81396178
8Glomerulonephritis (HP:0000099)3.54200091
9Recurrent gram-negative bacterial infections (HP:0005420)3.51824798
10Abnormality of liposaccharide metabolism (HP:0010968)3.46216664
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.46216664
12Abnormality of glycolipid metabolism (HP:0010969)3.46216664
13Symptomatic seizures (HP:0011145)3.43751600
14Abnormality of complement system (HP:0005339)3.32586967
15Hypobetalipoproteinemia (HP:0003563)3.31460002
16Hydroxyprolinuria (HP:0003080)3.28286615
17Abnormality of proline metabolism (HP:0010907)3.28286615
18Hypoglycemic seizures (HP:0002173)3.14259453
19Generalized aminoaciduria (HP:0002909)3.08822435
20Prolonged partial thromboplastin time (HP:0003645)3.06406786
21Hypoglycemic coma (HP:0001325)3.00788156
22Vacuolated lymphocytes (HP:0001922)2.97112809
23Abnormality of macrophages (HP:0004311)2.94612721
24Abnormality of magnesium homeostasis (HP:0004921)2.89262340
25Hyperinsulinemic hypoglycemia (HP:0000825)2.88382750
26Abnormality of urine glucose concentration (HP:0011016)2.81071715
27Glycosuria (HP:0003076)2.81071715
28Recurrent abscess formation (HP:0002722)2.64697387
29Late onset (HP:0003584)2.62678259
30Ketoacidosis (HP:0001993)2.62542185
31Hypomagnesemia (HP:0002917)2.59428533
32Fat malabsorption (HP:0002630)2.56952671
33Steatorrhea (HP:0002570)2.53564248
34Ketosis (HP:0001946)2.53358278
35Abnormality of vitamin B metabolism (HP:0004340)2.53119199
36Retinal atrophy (HP:0001105)2.46398642
37Hyperphosphaturia (HP:0003109)2.45921578
38Eczematoid dermatitis (HP:0000976)2.44711512
39Hypophosphatemia (HP:0002148)2.41505943
40Recurrent bacterial skin infections (HP:0005406)2.38616126
41Abnormality of vitamin metabolism (HP:0100508)2.37907352
42Hyperlipoproteinemia (HP:0010980)2.33681159
43Hyperglycemia (HP:0003074)2.33395851
44Nausea (HP:0002018)2.32428973
45Mitochondrial inheritance (HP:0001427)2.32076133
46Metaphyseal irregularity (HP:0003025)2.31131285
47Increased cerebral lipofuscin (HP:0011813)2.29682868
48Acute necrotizing encephalopathy (HP:0006965)2.28668902
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26448161
50Abnormality of glycine metabolism (HP:0010895)2.26371600
51Abnormality of serine family amino acid metabolism (HP:0010894)2.26371600
52Abnormality of the vitamin B12 metabolism (HP:0004341)2.25369734
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.25021498
54Metabolic alkalosis (HP:0200114)2.24693003
55Irritability (HP:0000737)2.24595636
56Dysostosis multiplex (HP:0000943)2.21205751
57Acute encephalopathy (HP:0006846)2.20988745
58Increased serum ferritin (HP:0003281)2.20612136
59Mutism (HP:0002300)2.20435112
60Hepatic necrosis (HP:0002605)2.19761811
61Vascular calcification (HP:0004934)2.17945555
62Deep venous thrombosis (HP:0002625)2.17863552
63Increased circulating renin level (HP:0000848)2.17373330
64Progressive macrocephaly (HP:0004481)2.16779424
65Hyperglycinuria (HP:0003108)2.14642052
66Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13391335
67Nephritis (HP:0000123)2.12818780
68Abnormality of pyrimidine metabolism (HP:0004353)2.12646881
69Renal Fanconi syndrome (HP:0001994)2.12515767
70Prolonged neonatal jaundice (HP:0006579)2.11817379
71Purpura (HP:0000979)2.11582821
72Abnormality of polysaccharide metabolism (HP:0011012)2.10186532
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10186532
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10186532
75Progressive neurologic deterioration (HP:0002344)2.08786858
76Lethargy (HP:0001254)2.07632693
77Tetany (HP:0001281)2.07465800
78Petechiae (HP:0000967)2.06918226
79Alkalosis (HP:0001948)2.05780535
80Megaloblastic anemia (HP:0001889)2.05152659
81Abnormal mitochondria in muscle tissue (HP:0008316)2.04135394
82Abnormal urine phosphate concentration (HP:0012599)2.02839946
83Insulin-resistant diabetes mellitus (HP:0000831)2.01847053
84Hyperglycinemia (HP:0002154)2.00779064
85Widely patent fontanelles and sutures (HP:0004492)2.00092907
86Hypothermia (HP:0002045)1.98869925
87Axonal loss (HP:0003447)1.97665550
88Abnormality of iron homeostasis (HP:0011031)1.97094161
89Intrahepatic cholestasis (HP:0001406)1.96994617
90Joint hemorrhage (HP:0005261)1.95255793
91Loss of speech (HP:0002371)1.95017623
92Urinary glycosaminoglycan excretion (HP:0003541)1.94875103
93Mucopolysacchariduria (HP:0008155)1.94875103
94Hepatocellular necrosis (HP:0001404)1.94393581
95Cerebral edema (HP:0002181)1.92602428
96Hyperammonemia (HP:0001987)1.92551842
97Abnormality of nucleobase metabolism (HP:0010932)1.91050006
98Abnormality of sulfur amino acid metabolism (HP:0004339)1.90855058
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90699737
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90699737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.75857915
2MAP3K123.55138438
3TESK13.06474726
4MST42.91597925
5NME22.57719189
6RIPK42.34616729
7FRK2.18276070
8TESK22.12211058
9ERN12.09770904
10LIMK12.05216146
11PRKG22.02341204
12LMTK21.96958315
13PINK11.96119938
14STK161.94196379
15MAP3K111.88103221
16DAPK21.83797543
17KDR1.80465033
18TYK21.77088596
19OXSR11.76623622
20ABL21.75828735
21BLK1.71739518
22MAP2K61.67525162
23ADRBK21.67467751
24NTRK31.59635199
25MAP3K21.56829311
26WNK31.49835414
27DDR21.47713703
28TGFBR21.42356211
29MAP3K31.36953454
30GRK71.36489257
31MATK1.31975152
32DAPK11.28315236
33CSK1.28302280
34IKBKE1.27987019
35IRAK31.26033813
36MAP3K11.23529708
37TAOK11.19861189
38TNIK1.19045701
39NLK1.11099810
40VRK21.08872074
41INSRR1.05704437
42MAP4K11.04321435
43STK391.01741798
44TBK11.01307042
45PASK1.00058561
46IKBKB0.98601573
47FGR0.97738285
48GRK10.96177315
49BCKDK0.95572215
50TXK0.86569798
51TAOK30.85113226
52ARAF0.81382266
53CAMKK20.80127598
54PHKG10.79923803
55PHKG20.79923803
56PRKCG0.78424309
57MYLK0.77974517
58TNK20.77600253
59STK240.77300130
60CAMK2D0.75878945
61EPHA20.75245224
62FGFR20.68933417
63CSF1R0.68193534
64CAMK2G0.64754562
65LYN0.64350651
66MAP4K20.64215971
67PRKAA20.63309724
68PRKCA0.62977717
69PRKCI0.61808809
70ZAP700.59087990
71IRAK40.58015056
72TAOK20.56235213
73PAK40.55211006
74PAK30.54866682
75PRKCQ0.53249197
76PRKACG0.52287809
77MAPKAPK30.52201740
78PDPK10.48919417
79CSNK1A10.47839303
80CDC42BPA0.45601070
81NME10.44737920
82DAPK30.44026490
83FER0.41185295
84PRKCZ0.41101665
85JAK10.40683067
86PRKCD0.40539379
87BMPR20.39628634
88HIPK20.39192718
89PRKACA0.38981960
90CSNK1G10.37960936
91PDK10.37954251
92RIPK10.36538096
93BMX0.36147909
94EIF2AK30.33974668
95MAP3K90.33935231
96CSNK1G30.33050313
97PDK20.32773364
98WNK40.31071743
99PRKG10.31060369
100CAMK2A0.28890093

Predicted pathways (KEGG)

RankGene SetZ-score
1* Mineral absorption_Homo sapiens_hsa049783.89807470
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.86573631
3Caffeine metabolism_Homo sapiens_hsa002322.69837167
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.35094068
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31770630
6Histidine metabolism_Homo sapiens_hsa003402.17784124
7Retinol metabolism_Homo sapiens_hsa008302.16845892
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.16787356
9Chemical carcinogenesis_Homo sapiens_hsa052042.15324102
10Complement and coagulation cascades_Homo sapiens_hsa046102.14477995
11Sulfur metabolism_Homo sapiens_hsa009202.03278178
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01726647
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98641222
14Tryptophan metabolism_Homo sapiens_hsa003801.97532537
15Oxidative phosphorylation_Homo sapiens_hsa001901.95797490
16Fatty acid degradation_Homo sapiens_hsa000711.85583077
17Fat digestion and absorption_Homo sapiens_hsa049751.84587116
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.83897692
19Folate biosynthesis_Homo sapiens_hsa007901.75698392
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72024596
21Vitamin digestion and absorption_Homo sapiens_hsa049771.70863979
22Arginine biosynthesis_Homo sapiens_hsa002201.69142021
23Collecting duct acid secretion_Homo sapiens_hsa049661.66342531
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.58883097
25PPAR signaling pathway_Homo sapiens_hsa033201.53695439
26Other glycan degradation_Homo sapiens_hsa005111.53344993
27Staphylococcus aureus infection_Homo sapiens_hsa051501.48826247
28Rheumatoid arthritis_Homo sapiens_hsa053231.45118397
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38481467
30Linoleic acid metabolism_Homo sapiens_hsa005911.38422340
31Phenylalanine metabolism_Homo sapiens_hsa003601.37485101
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37447823
33Butanoate metabolism_Homo sapiens_hsa006501.32671396
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.32316747
35Starch and sucrose metabolism_Homo sapiens_hsa005001.32109091
36Renin-angiotensin system_Homo sapiens_hsa046141.31608954
37Lysosome_Homo sapiens_hsa041421.29996319
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29945104
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26399681
40Vitamin B6 metabolism_Homo sapiens_hsa007501.26365091
41Arachidonic acid metabolism_Homo sapiens_hsa005901.24504735
42Bile secretion_Homo sapiens_hsa049761.22762919
43Tyrosine metabolism_Homo sapiens_hsa003501.21179630
44Proteasome_Homo sapiens_hsa030501.20392572
45Galactose metabolism_Homo sapiens_hsa000521.13298879
46Fructose and mannose metabolism_Homo sapiens_hsa000511.12516888
47Pertussis_Homo sapiens_hsa051331.12292906
48Glutathione metabolism_Homo sapiens_hsa004801.07387160
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06765493
50Peroxisome_Homo sapiens_hsa041461.05087493
51Parkinsons disease_Homo sapiens_hsa050121.03703376
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00295668
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98432311
54beta-Alanine metabolism_Homo sapiens_hsa004100.92565416
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.89119851
56Type I diabetes mellitus_Homo sapiens_hsa049400.88694239
57Arginine and proline metabolism_Homo sapiens_hsa003300.88391406
58Prion diseases_Homo sapiens_hsa050200.87307284
59Vibrio cholerae infection_Homo sapiens_hsa051100.87071580
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84706212
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84701988
62Alzheimers disease_Homo sapiens_hsa050100.78516317
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76957649
64Insulin secretion_Homo sapiens_hsa049110.75803034
65Synaptic vesicle cycle_Homo sapiens_hsa047210.73541848
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70328105
67Glycerolipid metabolism_Homo sapiens_hsa005610.65611999
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65147056
69Protein digestion and absorption_Homo sapiens_hsa049740.62742595
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61706215
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60837845
72Legionellosis_Homo sapiens_hsa051340.59899563
73Salmonella infection_Homo sapiens_hsa051320.59666037
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58160181
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58000194
76Sphingolipid metabolism_Homo sapiens_hsa006000.57496409
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56909019
78Protein export_Homo sapiens_hsa030600.55173040
79Ether lipid metabolism_Homo sapiens_hsa005650.55158468
80Metabolic pathways_Homo sapiens_hsa011000.54452096
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54067932
82Fatty acid elongation_Homo sapiens_hsa000620.52601248
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45997688
84Huntingtons disease_Homo sapiens_hsa050160.45959559
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.44004916
86Pyruvate metabolism_Homo sapiens_hsa006200.43797535
87Phagosome_Homo sapiens_hsa041450.43502036
88Fatty acid metabolism_Homo sapiens_hsa012120.42512051
89Pancreatic secretion_Homo sapiens_hsa049720.40286685
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39874010
91Sulfur relay system_Homo sapiens_hsa041220.39820560
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37752023
93Tuberculosis_Homo sapiens_hsa051520.36731282
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35955631
95African trypanosomiasis_Homo sapiens_hsa051430.34353322
96Carbon metabolism_Homo sapiens_hsa012000.32589035
97Osteoclast differentiation_Homo sapiens_hsa043800.30812714
98TNF signaling pathway_Homo sapiens_hsa046680.28769385
99Hematopoietic cell lineage_Homo sapiens_hsa046400.28140412
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26972215

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