MT1DP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)7.60478388
2actin nucleation (GO:0045010)7.43885329
3sequestering of actin monomers (GO:0042989)7.36399349
4response to pheromone (GO:0019236)6.68840124
5cytidine deamination (GO:0009972)5.91857495
6cytidine metabolic process (GO:0046087)5.91857495
7cytidine catabolic process (GO:0006216)5.91857495
8regulation of hexokinase activity (GO:1903299)5.69616584
9regulation of glucokinase activity (GO:0033131)5.69616584
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.22226940
11negative regulation of calcium ion transport into cytosol (GO:0010523)5.00324440
12pyrimidine ribonucleoside catabolic process (GO:0046133)4.93413803
13DNA deamination (GO:0045006)4.92358655
14positive regulation of lamellipodium assembly (GO:0010592)4.64194047
15natural killer cell differentiation (GO:0001779)4.62587247
16glycerol metabolic process (GO:0006071)4.56826715
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38070659
18regulation of gamma-delta T cell differentiation (GO:0045586)4.33114982
19regulation of natural killer cell differentiation (GO:0032823)4.27351909
20positive regulation of lamellipodium organization (GO:1902745)4.16202594
21myoblast migration (GO:0051451)4.07214565
22alditol metabolic process (GO:0019400)3.95835084
23cellular response to zinc ion (GO:0071294)3.87414173
24positive regulation of gamma-delta T cell activation (GO:0046645)3.67448505
25positive regulation of natural killer cell differentiation (GO:0032825)3.64610461
26regulation of regulatory T cell differentiation (GO:0045589)3.46546764
27deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.43238592
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41772058
29regulation of gamma-delta T cell activation (GO:0046643)3.36708997
30regulation of T cell tolerance induction (GO:0002664)3.35329259
31cellular response to cadmium ion (GO:0071276)3.29860690
32protein targeting to Golgi (GO:0000042)3.27262901
33positive regulation of tolerance induction (GO:0002645)3.25155767
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23910959
35negative regulation of T cell apoptotic process (GO:0070233)3.23841671
36phosphatidylethanolamine metabolic process (GO:0046337)3.18792974
37establishment of protein localization to Golgi (GO:0072600)3.18438481
38regulation of glucocorticoid secretion (GO:2000849)3.17971067
39regulation of interferon-beta biosynthetic process (GO:0045357)3.17152076
40endocrine pancreas development (GO:0031018)3.15293796
41keratinocyte development (GO:0003334)3.12276153
42regulation of lamellipodium assembly (GO:0010591)3.05974672
43protein neddylation (GO:0045116)3.03786884
44ATP synthesis coupled proton transport (GO:0015986)3.01851629
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.01851629
46regulation of T cell receptor signaling pathway (GO:0050856)3.00525144
47platelet dense granule organization (GO:0060155)2.96701726
48xenobiotic catabolic process (GO:0042178)2.95926052
49positive regulation of interleukin-17 production (GO:0032740)2.93128868
50T cell receptor signaling pathway (GO:0050852)2.86076922
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85136583
52L-phenylalanine catabolic process (GO:0006559)2.85136583
53regulation of activation of Janus kinase activity (GO:0010533)2.83781926
54positive T cell selection (GO:0043368)2.82522704
55regulation of rhodopsin mediated signaling pathway (GO:0022400)2.81520346
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79324837
57adaptation of signaling pathway (GO:0023058)2.79275332
58regulation of corticosteroid hormone secretion (GO:2000846)2.79166371
59retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78704326
60positive regulation of actin filament polymerization (GO:0030838)2.78012613
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77674261
62regulation of type B pancreatic cell apoptotic process (GO:2000674)2.76822915
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75619498
64L-phenylalanine metabolic process (GO:0006558)2.75619498
65piRNA metabolic process (GO:0034587)2.72289041
66lactate metabolic process (GO:0006089)2.72138011
67cytokine biosynthetic process (GO:0042089)2.71399378
68ribosomal small subunit assembly (GO:0000028)2.70853846
69positive regulation of calcium-mediated signaling (GO:0050850)2.69723262
70detection of light stimulus involved in sensory perception (GO:0050962)2.66074550
71detection of light stimulus involved in visual perception (GO:0050908)2.66074550
72regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.65699316
73ATP biosynthetic process (GO:0006754)2.65043387
74pyrimidine nucleoside catabolic process (GO:0046135)2.63155422
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.61550151
76regulation of lamellipodium organization (GO:1902743)2.61276004
77negative regulation of nitric-oxide synthase activity (GO:0051001)2.59692194
78regulation of tolerance induction (GO:0002643)2.59669502
79regulation of male gonad development (GO:2000018)2.58768627
80positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.57748744
81rhodopsin mediated signaling pathway (GO:0016056)2.57576107
82regulation of proton transport (GO:0010155)2.57420293
83positive regulation of natural killer cell mediated immunity (GO:0002717)2.55856132
84RNA destabilization (GO:0050779)2.53886523
85sperm motility (GO:0030317)2.53153113
86regulation of cholesterol esterification (GO:0010872)2.52849148
87purine deoxyribonucleotide catabolic process (GO:0009155)2.50604565
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49544991
89negative regulation of lymphocyte apoptotic process (GO:0070229)2.48797708
90negative regulation of Notch signaling pathway (GO:0045746)2.44950683
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.44873881
92regulation of secondary heart field cardioblast proliferation (GO:0003266)2.44626389
93regulation of cardioblast proliferation (GO:0003264)2.44626389
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.44409854
95regulation of T cell mediated cytotoxicity (GO:0001914)2.44157044
96electron transport chain (GO:0022900)2.42474920
97positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.42460648
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41511098
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.41307792
100adenine nucleotide transport (GO:0051503)2.39867852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat9.09150108
2VDR_22108803_ChIP-Seq_LS180_Human5.39242216
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.26227856
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99292364
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.92540335
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33974567
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.12642355
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35975304
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31301832
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15729821
11IRF1_19129219_ChIP-ChIP_H3396_Human1.97357869
12EZH2_22144423_ChIP-Seq_EOC_Human1.89246539
13BP1_19119308_ChIP-ChIP_Hs578T_Human1.86464039
14CBP_20019798_ChIP-Seq_JUKART_Human1.47167541
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47167541
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46115062
17PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.45338177
18MYB_26560356_Chip-Seq_TH2_Human1.43141190
19* NANOG_20526341_ChIP-Seq_ESCs_Human1.41211995
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35498262
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35031739
22ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34490721
23MYC_19829295_ChIP-Seq_ESCs_Human1.33995099
24TAF2_19829295_ChIP-Seq_ESCs_Human1.31488909
25AR_20517297_ChIP-Seq_VCAP_Human1.30371747
26RUNX_20019798_ChIP-Seq_JUKART_Human1.29527908
27GATA3_26560356_Chip-Seq_TH2_Human1.29342416
28TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27286725
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27119902
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25400826
31AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22354015
32TAF15_26573619_Chip-Seq_HEK293_Human1.22266974
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22029988
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21335567
35GBX2_23144817_ChIP-Seq_PC3_Human1.20777054
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19154665
37AR_25329375_ChIP-Seq_VCAP_Human1.19073546
38ER_23166858_ChIP-Seq_MCF-7_Human1.18210681
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17520474
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15100424
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14919856
42GATA3_27048872_Chip-Seq_THYMUS_Human1.13238942
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.11196307
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.11099089
45SMAD3_21741376_ChIP-Seq_ESCs_Human1.09179449
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07242761
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06913690
48BCL6_27268052_Chip-Seq_Bcells_Human1.06344148
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.05439850
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04028680
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03727887
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03687660
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03175732
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.00073693
55TAL1_26923725_Chip-Seq_HPCs_Mouse0.98872652
56* NCOR_22424771_ChIP-Seq_293T_Human0.98421448
57BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97918816
58RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97648738
59* NANOG_19829295_ChIP-Seq_ESCs_Human0.97526252
60* SOX2_19829295_ChIP-Seq_ESCs_Human0.97526252
61FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94732396
62FOXA1_25329375_ChIP-Seq_VCAP_Human0.94732396
63CDX2_22108803_ChIP-Seq_LS180_Human0.94421374
64TCF4_22108803_ChIP-Seq_LS180_Human0.92599605
65* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92070695
66MYB_26560356_Chip-Seq_TH1_Human0.90656315
67YY1_22570637_ChIP-Seq_MALME-3M_Human0.89458918
68P300_19829295_ChIP-Seq_ESCs_Human0.89158704
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88494045
70* ERA_21632823_ChIP-Seq_H3396_Human0.87688555
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86675689
72ERG_20517297_ChIP-Seq_VCAP_Human0.86213101
73ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85222669
74TP53_22573176_ChIP-Seq_HFKS_Human0.84640972
75PIAS1_25552417_ChIP-Seq_VCAP_Human0.84228586
76CBX2_27304074_Chip-Seq_ESCs_Mouse0.83540173
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80940477
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.80518477
79SMAD4_21741376_ChIP-Seq_EPCs_Human0.80056549
80ZNF274_21170338_ChIP-Seq_K562_Hela0.79963843
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.79483658
82ETV1_20927104_ChIP-Seq_GIST48_Human0.78414661
83FUS_26573619_Chip-Seq_HEK293_Human0.78110423
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.77428945
85MAF_26560356_Chip-Seq_TH2_Human0.77170070
86SA1_27219007_Chip-Seq_Bcells_Human0.77000305
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76778886
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.76772053
89HTT_18923047_ChIP-ChIP_STHdh_Human0.76335815
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75623295
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75623295
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75583930
93BCAT_22108803_ChIP-Seq_LS180_Human0.74867969
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74826361
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74308516
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73744598
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.73395035
98UTX_26944678_Chip-Seq_JUKART_Human0.72467396
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.71832813
100SMRT_27268052_Chip-Seq_Bcells_Human0.71813663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005379_endocrine/exocrine_gland_phen3.50692465
2MP0002638_abnormal_pupillary_reflex3.13546952
3MP0002837_dystrophic_cardiac_calcinosis3.07344738
4MP0009840_abnormal_foam_cell3.01494908
5MP0009333_abnormal_splenocyte_physiolog2.91760764
6MP0001661_extended_life_span2.80574700
7MP0005671_abnormal_response_to2.66120719
8MP0002102_abnormal_ear_morphology2.61153005
9MP0001348_abnormal_lacrimal_gland2.51365410
10MP0005410_abnormal_fertilization2.33265931
11MP0003195_calcinosis2.19784587
12MP0002138_abnormal_hepatobiliary_system2.09686299
13MP0002166_altered_tumor_susceptibility2.01844482
14MP0002139_abnormal_hepatobiliary_system2.01727491
15MP0003786_premature_aging1.99345645
16MP0008961_abnormal_basal_metabolism1.98365531
17MP0003879_abnormal_hair_cell1.97522419
18MP0009785_altered_susceptibility_to1.95306886
19MP0005670_abnormal_white_adipose1.86874648
20MP0002693_abnormal_pancreas_physiology1.84833116
21MP0004043_abnormal_pH_regulation1.80667674
22MP0001968_abnormal_touch/_nociception1.75943689
23MP0004134_abnormal_chest_morphology1.72895369
24MP0002148_abnormal_hypersensitivity_rea1.69764264
25MP0002909_abnormal_adrenal_gland1.66486669
26MP0004381_abnormal_hair_follicle1.66073754
27MP0005257_abnormal_intraocular_pressure1.64046020
28MP0002277_abnormal_respiratory_mucosa1.63784068
29MP0005000_abnormal_immune_tolerance1.63022968
30MP0005075_abnormal_melanosome_morpholog1.62586932
31MP0010329_abnormal_lipoprotein_level1.60660073
32MP0008872_abnormal_physiological_respon1.58503985
33MP0002006_tumorigenesis1.52905395
34MP0001790_abnormal_immune_system1.50552516
35MP0005387_immune_system_phenotype1.50552516
36MP0003806_abnormal_nucleotide_metabolis1.49606806
37MP0003718_maternal_effect1.48452189
38MP0004883_abnormal_blood_vessel1.47548527
39MP0001905_abnormal_dopamine_level1.45166102
40MP0005645_abnormal_hypothalamus_physiol1.42130060
41MP0005551_abnormal_eye_electrophysiolog1.41774081
42MP0000604_amyloidosis1.39243375
43MP0006072_abnormal_retinal_apoptosis1.36668206
44MP0002723_abnormal_immune_serum1.34273717
45MP0003646_muscle_fatigue1.30626852
46MP0001986_abnormal_taste_sensitivity1.28221312
47MP0005535_abnormal_body_temperature1.24253208
48MP0002933_joint_inflammation1.22175683
49MP0008877_abnormal_DNA_methylation1.22055544
50MP0001879_abnormal_lymphatic_vessel1.19548913
51MP0005025_abnormal_response_to1.19185957
52MP0001800_abnormal_humoral_immune1.16254779
53MP0002078_abnormal_glucose_homeostasis1.15419587
54MP0001944_abnormal_pancreas_morphology1.14913482
55MP0005164_abnormal_response_to1.09671084
56MP0003878_abnormal_ear_physiology1.08446626
57MP0005377_hearing/vestibular/ear_phenot1.08446626
58MP0009643_abnormal_urine_homeostasis1.07695561
59MP0005636_abnormal_mineral_homeostasis1.07516385
60MP0000372_irregular_coat_pigmentation1.07464909
61MP0003252_abnormal_bile_duct1.05415381
62MP0002420_abnormal_adaptive_immunity1.04858247
63MP0009697_abnormal_copulation1.04519442
64MP0003172_abnormal_lysosome_physiology1.04222462
65MP0001666_abnormal_nutrient_absorption1.04210125
66MP0010234_abnormal_vibrissa_follicle1.00664381
67MP0000685_abnormal_immune_system0.99182375
68MP0001819_abnormal_immune_cell0.97087772
69MP0005360_urolithiasis0.96805447
70MP0008007_abnormal_cellular_replicative0.94771731
71MP0001764_abnormal_homeostasis0.93931665
72MP0001984_abnormal_olfaction0.93841371
73MP0001845_abnormal_inflammatory_respons0.91589027
74MP0005253_abnormal_eye_physiology0.91267190
75MP0009745_abnormal_behavioral_response0.90486196
76MP0005448_abnormal_energy_balance0.90068343
77MP0001765_abnormal_ion_homeostasis0.89911893
78MP0003698_abnormal_male_reproductive0.89708975
79MP0000467_abnormal_esophagus_morphology0.89631898
80MP0002557_abnormal_social/conspecific_i0.89371986
81MP0002090_abnormal_vision0.88870054
82MP0005646_abnormal_pituitary_gland0.87999083
83MP0000230_abnormal_systemic_arterial0.87919141
84MP0001929_abnormal_gametogenesis0.87271239
85MP0001853_heart_inflammation0.86021583
86MP0008469_abnormal_protein_level0.85894856
87MP0006082_CNS_inflammation0.85804286
88MP0002452_abnormal_antigen_presenting0.85496714
89MP0000427_abnormal_hair_cycle0.84242378
90MP0000609_abnormal_liver_physiology0.83690654
91MP0002118_abnormal_lipid_homeostasis0.83635013
92MP0005376_homeostasis/metabolism_phenot0.81035408
93MP0005332_abnormal_amino_acid0.79094640
94MP0003011_delayed_dark_adaptation0.78909543
95MP0001756_abnormal_urination0.78184674
96MP0005084_abnormal_gallbladder_morpholo0.78121787
97MP0002970_abnormal_white_adipose0.77365056
98MP0002876_abnormal_thyroid_physiology0.77237105
99MP0005085_abnormal_gallbladder_physiolo0.77117448
100MP0001243_abnormal_dermal_layer0.76608837

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)6.33701923
2Ketoacidosis (HP:0001993)5.33589953
3Abnormality of the pancreatic islet cells (HP:0006476)4.73697157
4Abnormality of endocrine pancreas physiology (HP:0012093)4.73697157
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.35579474
6Generalized aminoaciduria (HP:0002909)4.19039579
7Ketosis (HP:0001946)4.18914349
8Symptomatic seizures (HP:0011145)4.05998616
9Abnormal rod and cone electroretinograms (HP:0008323)3.87220558
10Renal Fanconi syndrome (HP:0001994)3.79381455
11Abnormality of urine glucose concentration (HP:0011016)3.37324939
12Glycosuria (HP:0003076)3.37324939
13Hypoglycemic coma (HP:0001325)3.34956387
14Late onset (HP:0003584)3.32257393
15Severe visual impairment (HP:0001141)3.30268365
16Congenital stationary night blindness (HP:0007642)3.22849304
17Thyroiditis (HP:0100646)3.14421781
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05623036
19Recurrent corneal erosions (HP:0000495)2.99764118
20Mitochondrial inheritance (HP:0001427)2.96473950
21Hyperinsulinemic hypoglycemia (HP:0000825)2.93019295
22Prostate neoplasm (HP:0100787)2.87469951
23Alacrima (HP:0000522)2.85514618
24Abnormality of dental color (HP:0011073)2.82456582
25Aplasia of the musculature (HP:0100854)2.78924743
26Insulin-resistant diabetes mellitus (HP:0000831)2.78199963
27Orthostatic hypotension (HP:0001278)2.76530884
28Pancreatic islet-cell hyperplasia (HP:0004510)2.75620863
29Abnormality of chromosome stability (HP:0003220)2.75119813
30Hyperphosphaturia (HP:0003109)2.74959690
31Tubulointerstitial nephritis (HP:0001970)2.72707836
32T lymphocytopenia (HP:0005403)2.66888084
33Abnormality of T cell number (HP:0011839)2.66839641
34Increased hepatocellular lipid droplets (HP:0006565)2.65198572
35Abnormality of the fovea (HP:0000493)2.65147288
36Central scotoma (HP:0000603)2.54752841
37Acute necrotizing encephalopathy (HP:0006965)2.54085730
38Progressive macrocephaly (HP:0004481)2.52393174
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47678529
40Elevated erythrocyte sedimentation rate (HP:0003565)2.46543082
41Chorioretinal atrophy (HP:0000533)2.43986385
42Partial duplication of the phalanx of hand (HP:0009999)2.40607401
43Abnormality of renal resorption (HP:0011038)2.40271264
44Renal cortical cysts (HP:0000803)2.39431809
45Hepatic necrosis (HP:0002605)2.38273435
46Partial duplication of thumb phalanx (HP:0009944)2.34764500
47Abnormality of macular pigmentation (HP:0008002)2.29925562
48Spontaneous abortion (HP:0005268)2.28639438
49Lipid accumulation in hepatocytes (HP:0006561)2.27675595
50Hyperglycemia (HP:0003074)2.27319920
51Amyotrophic lateral sclerosis (HP:0007354)2.25510450
52Insulin resistance (HP:0000855)2.24989632
53Autoimmune hemolytic anemia (HP:0001890)2.24616537
54Complement deficiency (HP:0004431)2.23218758
55Abnormal urine phosphate concentration (HP:0012599)2.21803391
56Attenuation of retinal blood vessels (HP:0007843)2.20369674
57Decreased lacrimation (HP:0000633)2.15453222
58Hypophosphatemic rickets (HP:0004912)2.12098230
59Stomatitis (HP:0010280)2.11085855
60Chronic hepatic failure (HP:0100626)2.07118241
61Increased CSF lactate (HP:0002490)2.06137001
62Severe combined immunodeficiency (HP:0004430)2.05809151
63Abolished electroretinogram (ERG) (HP:0000550)2.04214162
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02740979
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02740979
66Pendular nystagmus (HP:0012043)2.00512107
67Facial shape deformation (HP:0011334)1.99914791
68Potter facies (HP:0002009)1.99914791
69Retinal atrophy (HP:0001105)1.99734707
70Metaphyseal dysplasia (HP:0100255)1.98707667
71Absent thumb (HP:0009777)1.97369366
72Male infertility (HP:0003251)1.97319464
73Abnormal mitochondria in muscle tissue (HP:0008316)1.97169971
74Abnormality of the preputium (HP:0100587)1.96983601
75Hyperlipoproteinemia (HP:0010980)1.96657237
76Exertional dyspnea (HP:0002875)1.96418422
77Increased intramyocellular lipid droplets (HP:0012240)1.94188785
78Small epiphyses (HP:0010585)1.93266211
79Acute encephalopathy (HP:0006846)1.88357687
80Abnormality of eosinophils (HP:0001879)1.87275904
81Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86548518
82Osteomalacia (HP:0002749)1.80186934
83Abnormal sex determination (HP:0012244)1.79982985
84Sex reversal (HP:0012245)1.79982985
85Brushfield spots (HP:0001088)1.79362488
86Decreased central vision (HP:0007663)1.78987889
87Increased muscle lipid content (HP:0009058)1.77771347
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.75993521
89Agitation (HP:0000713)1.75212511
90Leukocytosis (HP:0001974)1.75115096
91Azoospermia (HP:0000027)1.74421765
92Cerebral edema (HP:0002181)1.73636300
93Increased IgE level (HP:0003212)1.72516565
94Hypoplasia of the pons (HP:0012110)1.71002760
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.70392656
96Hypoplasia of the fovea (HP:0007750)1.70392656
97Sparse lateral eyebrow (HP:0005338)1.69724127
98Abnormality of the costochondral junction (HP:0000919)1.68243206
99Exocrine pancreatic insufficiency (HP:0001738)1.64597745
100Type I diabetes mellitus (HP:0100651)1.64097748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.24147768
2PASK3.89481675
3MAP3K123.66962268
4TLK13.57209107
5FRK3.27912120
6STK162.96343258
7PINK12.90299079
8ADRBK22.52489125
9TESK22.52462228
10PLK42.33692262
11TESK12.30687234
12BCKDK2.18879564
13ZAK2.13089999
14MST41.97503401
15LIMK11.94158377
16GRK71.88205829
17STK391.84745671
18INSRR1.79259766
19ACVR1B1.78199336
20MYLK1.75452333
21VRK11.66364416
22TAOK21.63498096
23NLK1.48641427
24EPHB11.42190843
25TIE11.39144663
26JAK11.33187282
27TBK11.30532360
28MAP4K21.26450039
29WNK41.23704685
30GRK11.18262984
31FES1.17687246
32SCYL21.14943017
33IKBKE1.12073214
34VRK21.10847745
35MAP3K31.06746980
36MAP3K111.06603605
37ITK1.01912202
38PRPF4B1.01690010
39ZAP701.00285607
40OBSCN0.99971857
41EPHA30.97672902
42ROCK10.93652520
43ADRBK10.91904383
44PRKCQ0.90100039
45TRPM70.88465750
46OXSR10.83671803
47AKT30.81949313
48STK240.80469752
49CAMKK10.80044206
50TNIK0.77888587
51PAK10.75479857
52CASK0.74681870
53PRKG20.72165006
54MAP3K10.70468045
55BMX0.70214785
56PLK20.68829749
57DAPK30.64140687
58FER0.62504350
59PAK30.59004099
60LCK0.58860923
61SGK20.58732442
62CSK0.58644857
63PTK2B0.58415586
64RPS6KA50.57448658
65PAK40.55901962
66BMPR1B0.55850205
67PIK3CG0.54241404
68HIPK20.53830330
69TAOK10.51989445
70IKBKB0.49470432
71TRIM280.49299042
72RPS6KA40.49205253
73SYK0.49131041
74AURKA0.48623965
75PRKCI0.40514503
76FGFR20.38966352
77WNK30.38899042
78FGFR30.38581230
79MAP3K90.38096925
80PDGFRB0.37343611
81PRKCA0.36853407
82SGK2230.36256778
83SGK4940.36256778
84GRK60.35456894
85LMTK20.33859196
86MAPKAPK50.33074914
87CAMK2A0.31690453
88DMPK0.29723728
89PKN10.27871883
90PRKCH0.27711375
91EGFR0.26301548
92CSNK1G30.26288046
93PRKACA0.25576509
94CSNK1G10.25058274
95TYK20.24769026
96PIM10.24479157
97BRD40.24263136
98AKT20.22922374
99PRKCE0.21749857
100PRKCG0.19956517

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.70360772
2Oxidative phosphorylation_Homo sapiens_hsa001903.63065533
3Proteasome_Homo sapiens_hsa030502.87627392
4Primary immunodeficiency_Homo sapiens_hsa053402.81452802
5Hematopoietic cell lineage_Homo sapiens_hsa046402.56037933
6Parkinsons disease_Homo sapiens_hsa050122.53524893
7Phototransduction_Homo sapiens_hsa047442.40245478
8Caffeine metabolism_Homo sapiens_hsa002322.17997703
9T cell receptor signaling pathway_Homo sapiens_hsa046602.14553403
10Protein export_Homo sapiens_hsa030602.09638508
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06794273
12Tryptophan metabolism_Homo sapiens_hsa003801.85743619
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84672398
14Alzheimers disease_Homo sapiens_hsa050101.82947742
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74550438
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69206272
17Complement and coagulation cascades_Homo sapiens_hsa046101.68489590
18Type I diabetes mellitus_Homo sapiens_hsa049401.63528689
19Peroxisome_Homo sapiens_hsa041461.63291163
20Butanoate metabolism_Homo sapiens_hsa006501.63267294
21Huntingtons disease_Homo sapiens_hsa050161.55341570
22Cardiac muscle contraction_Homo sapiens_hsa042601.51779637
23Retinol metabolism_Homo sapiens_hsa008301.39564319
24Chemical carcinogenesis_Homo sapiens_hsa052041.31173827
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31040652
26Collecting duct acid secretion_Homo sapiens_hsa049661.30778616
27Linoleic acid metabolism_Homo sapiens_hsa005911.26199898
28Phenylalanine metabolism_Homo sapiens_hsa003601.25234547
29Folate biosynthesis_Homo sapiens_hsa007901.24594502
30Fatty acid degradation_Homo sapiens_hsa000711.23653390
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21743270
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.20820049
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.14210545
34Insulin secretion_Homo sapiens_hsa049111.13942897
35Antigen processing and presentation_Homo sapiens_hsa046121.13756697
36Mineral absorption_Homo sapiens_hsa049781.13362814
37Prion diseases_Homo sapiens_hsa050201.11984792
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11931643
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07786041
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06960176
41Fatty acid biosynthesis_Homo sapiens_hsa000611.06086348
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01983240
43Fanconi anemia pathway_Homo sapiens_hsa034600.99472987
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.97762092
45Fat digestion and absorption_Homo sapiens_hsa049750.95495738
46Homologous recombination_Homo sapiens_hsa034400.90771831
47Autoimmune thyroid disease_Homo sapiens_hsa053200.88126468
48Graft-versus-host disease_Homo sapiens_hsa053320.86577536
49Sulfur metabolism_Homo sapiens_hsa009200.86222029
50Allograft rejection_Homo sapiens_hsa053300.84435002
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83162106
52Olfactory transduction_Homo sapiens_hsa047400.82817637
53Ribosome_Homo sapiens_hsa030100.82688382
54Measles_Homo sapiens_hsa051620.82322883
55Nitrogen metabolism_Homo sapiens_hsa009100.82013171
56Regulation of autophagy_Homo sapiens_hsa041400.80962316
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79876230
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79274720
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.76961642
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75761606
61PPAR signaling pathway_Homo sapiens_hsa033200.74684638
62Synaptic vesicle cycle_Homo sapiens_hsa047210.73988372
63Fatty acid metabolism_Homo sapiens_hsa012120.73487808
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71756498
65Arachidonic acid metabolism_Homo sapiens_hsa005900.71669330
66Rheumatoid arthritis_Homo sapiens_hsa053230.71603262
67Propanoate metabolism_Homo sapiens_hsa006400.70832607
68Tyrosine metabolism_Homo sapiens_hsa003500.70467570
69Vibrio cholerae infection_Homo sapiens_hsa051100.70404490
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.69000966
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68412965
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.65762996
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65712067
74Basal transcription factors_Homo sapiens_hsa030220.64133024
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61643196
76Systemic lupus erythematosus_Homo sapiens_hsa053220.61076202
77RNA polymerase_Homo sapiens_hsa030200.60987392
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.58997169
79Vitamin B6 metabolism_Homo sapiens_hsa007500.55068479
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51953588
81Base excision repair_Homo sapiens_hsa034100.51729867
82Malaria_Homo sapiens_hsa051440.49930984
83Taste transduction_Homo sapiens_hsa047420.48704479
84Fatty acid elongation_Homo sapiens_hsa000620.48313293
85Metabolic pathways_Homo sapiens_hsa011000.47326275
86Histidine metabolism_Homo sapiens_hsa003400.45789115
87Type II diabetes mellitus_Homo sapiens_hsa049300.45532271
88Salivary secretion_Homo sapiens_hsa049700.45338837
89Pancreatic secretion_Homo sapiens_hsa049720.43163759
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42868206
91Ether lipid metabolism_Homo sapiens_hsa005650.41468277
92Legionellosis_Homo sapiens_hsa051340.40605289
93ABC transporters_Homo sapiens_hsa020100.39060754
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38333318
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37704075
96Insulin resistance_Homo sapiens_hsa049310.36956854
97Bile secretion_Homo sapiens_hsa049760.36731595
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36307622
99Pertussis_Homo sapiens_hsa051330.35573955
100Renin secretion_Homo sapiens_hsa049240.35197608

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