MT-ND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.62817810
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.96977697
3ATP synthesis coupled proton transport (GO:0015986)5.96977697
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.58915756
5* respiratory electron transport chain (GO:0022904)5.06434084
6* electron transport chain (GO:0022900)4.91184762
7neuronal action potential propagation (GO:0019227)4.90659037
8regulation of female receptivity (GO:0045924)4.76681266
9vocalization behavior (GO:0071625)4.66136873
10ribosomal small subunit biogenesis (GO:0042274)4.63742063
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59497298
12female mating behavior (GO:0060180)4.45483837
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44645095
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40885219
15cerebellar granule cell differentiation (GO:0021707)4.39772556
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.18669208
17locomotory exploration behavior (GO:0035641)4.14816034
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.01690523
19synaptic vesicle exocytosis (GO:0016079)4.00030772
20dendritic spine morphogenesis (GO:0060997)3.97286035
21creatine metabolic process (GO:0006600)3.89592577
22regulation of glutamate receptor signaling pathway (GO:1900449)3.87292718
23potassium ion homeostasis (GO:0055075)3.86191032
24neuron cell-cell adhesion (GO:0007158)3.85127834
25protein localization to synapse (GO:0035418)3.82206573
26negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.77029380
27synaptic vesicle maturation (GO:0016188)3.73036080
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72377795
29glutamate receptor signaling pathway (GO:0007215)3.70908101
30cellular sodium ion homeostasis (GO:0006883)3.69320513
31amino acid import (GO:0043090)3.59458730
32regulation of oxidative phosphorylation (GO:0002082)3.59335746
33layer formation in cerebral cortex (GO:0021819)3.50002351
34transmission of nerve impulse (GO:0019226)3.49307500
35regulation of synaptic vesicle exocytosis (GO:2000300)3.47058358
36neuron-neuron synaptic transmission (GO:0007270)3.46666338
37positive regulation of cellular amine metabolic process (GO:0033240)3.45735250
38viral transcription (GO:0019083)3.44608100
39ATP biosynthetic process (GO:0006754)3.43764316
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43700222
41glutamate secretion (GO:0014047)3.42277094
42synaptic transmission, glutamatergic (GO:0035249)3.42137426
43sleep (GO:0030431)3.40109328
44regulation of synapse maturation (GO:0090128)3.38945137
45exploration behavior (GO:0035640)3.37394132
46long-term memory (GO:0007616)3.37128922
47regulation of neuronal synaptic plasticity (GO:0048168)3.36604834
48oxidative phosphorylation (GO:0006119)3.36123450
49neurotransmitter secretion (GO:0007269)3.35580677
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35350771
51regulation of dendritic spine morphogenesis (GO:0061001)3.32781677
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23674550
53regulation of synapse structural plasticity (GO:0051823)3.23620621
54axon ensheathment in central nervous system (GO:0032291)3.22672356
55central nervous system myelination (GO:0022010)3.22672356
56neuron recognition (GO:0008038)3.22551782
57cellular potassium ion homeostasis (GO:0030007)3.22091936
58positive regulation of membrane potential (GO:0045838)3.21230429
59phosphate ion transmembrane transport (GO:0035435)3.20203191
60regulation of synaptic vesicle transport (GO:1902803)3.19505801
61L-phenylalanine metabolic process (GO:0006558)3.18371056
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.18371056
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16054123
64L-phenylalanine catabolic process (GO:0006559)3.16054123
65regulation of dopamine metabolic process (GO:0042053)3.15943886
66regulation of catecholamine metabolic process (GO:0042069)3.15943886
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15156720
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.12554873
69gamma-aminobutyric acid transport (GO:0015812)3.12337817
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07077150
71hydrogen ion transmembrane transport (GO:1902600)3.06892800
72translational termination (GO:0006415)3.06774606
73neurotransmitter transport (GO:0006836)3.05569016
74response to parathyroid hormone (GO:0071107)3.04500507
75neuromuscular process controlling posture (GO:0050884)2.99468088
76myelin maintenance (GO:0043217)2.97769613
77purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96794179
78regulation of early endosome to late endosome transport (GO:2000641)2.95504366
79peptidyl-tyrosine autophosphorylation (GO:0038083)2.95168358
80synaptic vesicle docking involved in exocytosis (GO:0016081)2.94822564
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94724501
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.94131908
83positive regulation of potassium ion transmembrane transport (GO:1901381)2.93906067
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92558586
85regulation of retinoic acid receptor signaling pathway (GO:0048385)2.92438997
86regulation of ARF protein signal transduction (GO:0032012)2.91082941
87positive regulation of dendritic spine development (GO:0060999)2.90478461
88detection of calcium ion (GO:0005513)2.90374308
89auditory behavior (GO:0031223)2.88890322
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87513357
91NADH metabolic process (GO:0006734)2.87034399
92behavioral response to cocaine (GO:0048148)2.86357511
93positive regulation of neurotransmitter secretion (GO:0001956)2.86061546
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.85331591
95regulation of postsynaptic membrane potential (GO:0060078)2.84832801
96regulation of voltage-gated calcium channel activity (GO:1901385)2.83965447
97cell communication by electrical coupling (GO:0010644)2.83267643
98membrane hyperpolarization (GO:0060081)2.83100130
99righting reflex (GO:0060013)2.82410282
100activation of protein kinase A activity (GO:0034199)2.81867045
101phosphate ion transport (GO:0006817)2.80338948
102dendritic spine organization (GO:0097061)2.79511475
103glycine transport (GO:0015816)2.77907061
104negative regulation of erythrocyte differentiation (GO:0045647)2.77752853
105sodium ion homeostasis (GO:0055078)2.77328869
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76186456
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.75946579
108sodium ion export (GO:0071436)2.74968681
109regulation of neurotransmitter levels (GO:0001505)2.73195440
110chaperone-mediated protein transport (GO:0072321)2.72246952
111regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.71901380
112mating behavior (GO:0007617)2.71124256
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.70967653
114positive regulation of neurotransmitter transport (GO:0051590)2.70905207
115regulation of dendritic spine development (GO:0060998)2.70540546
116response to histamine (GO:0034776)2.68468240
117positive regulation of potassium ion transport (GO:0043268)2.67874556
118cochlea development (GO:0090102)2.67715094
119L-amino acid import (GO:0043092)2.67112813
120regulation of vesicle fusion (GO:0031338)2.67101929
121regulation of membrane repolarization (GO:0060306)2.66900285
122neuronal ion channel clustering (GO:0045161)2.66160061
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65525190
124phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.65056648
125axonal fasciculation (GO:0007413)2.65027703
126potassium ion import (GO:0010107)2.62488835
127positive regulation of synapse maturation (GO:0090129)2.61062978
128neuromuscular process controlling balance (GO:0050885)2.60052846
129prepulse inhibition (GO:0060134)2.59666941
130regulation of synaptic plasticity (GO:0048167)2.58985000
131proton transport (GO:0015992)2.58801645
132behavioral fear response (GO:0001662)2.58682569
133behavioral defense response (GO:0002209)2.58682569
134ribonucleoside triphosphate biosynthetic process (GO:0009201)2.58221634
135positive regulation of protein dephosphorylation (GO:0035307)2.55783080
136startle response (GO:0001964)2.55560347
137cell communication involved in cardiac conduction (GO:0086065)2.55129310
138cellular protein complex disassembly (GO:0043624)2.54925148
139regulation of neurotransmitter secretion (GO:0046928)2.54776329
140regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.54102265
141positive regulation of sodium ion transport (GO:0010765)2.53299741
142relaxation of smooth muscle (GO:0044557)2.53036292
143regulation of sensory perception of pain (GO:0051930)2.51145139
144regulation of sensory perception (GO:0051931)2.51145139
145oxaloacetate metabolic process (GO:0006107)2.49857499
146cGMP-mediated signaling (GO:0019934)2.49737732
147synaptonemal complex organization (GO:0070193)2.49356888
148positive regulation of Rap GTPase activity (GO:0032854)2.47838496
149membrane repolarization (GO:0086009)2.46957918
150cardiac conduction (GO:0061337)2.44005265
151cardiac muscle adaptation (GO:0014887)2.42372953
152cardiac muscle hypertrophy in response to stress (GO:0014898)2.42372953
153muscle hypertrophy in response to stress (GO:0003299)2.42372953
154translational elongation (GO:0006414)2.40422634
155regulation of cellular respiration (GO:0043457)2.37748017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16110128
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.43149468
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.34834769
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15270664
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89422014
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86232593
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85512698
8GBX2_23144817_ChIP-Seq_PC3_Human2.85208972
9ZNF263_19887448_ChIP-Seq_K562_Human2.83623291
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.70502530
11LXR_22292898_ChIP-Seq_THP-1_Human2.65463054
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54077879
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54077879
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48720774
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47579094
16REST_21632747_ChIP-Seq_MESCs_Mouse2.47122631
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43891539
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40488088
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38078766
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32351815
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.23449060
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21063357
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09586156
24SRY_22984422_ChIP-ChIP_TESTIS_Rat2.09199223
25P68_20966046_ChIP-Seq_HELA_Human2.05986984
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.05054296
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.03970697
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02943013
29ESR2_21235772_ChIP-Seq_MCF-7_Human2.00947514
30TAF15_26573619_Chip-Seq_HEK293_Human1.99640344
31SMC4_20622854_ChIP-Seq_HELA_Human1.98981034
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.97262056
33VDR_22108803_ChIP-Seq_LS180_Human1.95467473
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.94199348
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92818021
36ZNF274_21170338_ChIP-Seq_K562_Hela1.92251816
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.91803923
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89218942
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88348231
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.88058423
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87444200
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.86186625
43KDM2B_26808549_Chip-Seq_K562_Human1.84869340
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83855089
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83169675
46CTCF_27219007_Chip-Seq_Bcells_Human1.80234536
47RACK7_27058665_Chip-Seq_MCF-7_Human1.77593780
48FUS_26573619_Chip-Seq_HEK293_Human1.74601766
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.71568955
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71412146
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70712857
52DROSHA_22980978_ChIP-Seq_HELA_Human1.68899803
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68232825
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67245524
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65783453
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.62836700
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62443233
58CREB1_26743006_Chip-Seq_LNCaP_Human1.60676774
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60569402
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58950419
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57466417
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57133992
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55350864
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54630767
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50121348
66VDR_21846776_ChIP-Seq_THP-1_Human1.48844099
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48202710
68STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.46449045
69CTCF_20526341_ChIP-Seq_ESCs_Human1.44825619
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.44614193
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44083698
72SA1_27219007_Chip-Seq_Bcells_Human1.43041335
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42524472
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42524472
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42524472
76RNF2_27304074_Chip-Seq_NSC_Mouse1.42229074
77BCOR_27268052_Chip-Seq_Bcells_Human1.42102369
78SMAD4_21799915_ChIP-Seq_A2780_Human1.38757330
79KDM2B_26808549_Chip-Seq_DND41_Human1.37526582
80P300_19829295_ChIP-Seq_ESCs_Human1.36584555
81OCT4_19829295_ChIP-Seq_ESCs_Human1.36483823
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34365760
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32695534
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32096023
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31159585
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31061705
87AR_21572438_ChIP-Seq_LNCaP_Human1.30474754
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.29396059
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29383088
90TCF7_22412390_ChIP-Seq_EML_Mouse1.28426721
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.27940101
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.26622188
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24506845
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24460399
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23577543
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22426260
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20381979
98BCL6_27268052_Chip-Seq_Bcells_Human1.19666547
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.19478853
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18100056
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.17559415
102TP63_22573176_ChIP-Seq_HFKS_Human1.17517387
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16866603
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16747780
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16566186
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16309583
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15959870
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13342900
109ER_23166858_ChIP-Seq_MCF-7_Human1.10747340
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10182459
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10057458
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09815375
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09425441
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.09158954
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09014973
116E2F1_20622854_ChIP-Seq_HELA_Human1.08443594
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.08171347
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06620964
119CTCF_26484167_Chip-Seq_Bcells_Mouse1.06589827
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06507658
121RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06499509
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04666268
123RUNX1_27514584_Chip-Seq_MCF-7_Human1.04290671
124STAT1_20625510_ChIP-Seq_HELA_Human1.03633575
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.03440258
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03307183
127PHF8_20622854_ChIP-Seq_HELA_Human1.02740054
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01999198
129ELK3_25401928_ChIP-Seq_HUVEC_Human1.01560514
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01322855
131JUN_21703547_ChIP-Seq_K562_Human1.00934153
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00435954
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00196590
134EWS_26573619_Chip-Seq_HEK293_Human0.99963576
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.99924221
136MYC_22102868_ChIP-Seq_BL_Human0.99849459
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99830827
138KLF4_19829295_ChIP-Seq_ESCs_Human0.99522171
139AR_25329375_ChIP-Seq_VCAP_Human0.98204212
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94454592
141RUNX2_22187159_ChIP-Seq_PCA_Human0.91620010
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91618364
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91081582
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90803671
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88796751
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88253255
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88253141
148STAT3_23295773_ChIP-Seq_U87_Human0.88196705
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87849413
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87648633
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87028127
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86139378
153TCF4_23295773_ChIP-Seq_U87_Human0.85508591
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.85051863
155HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84873112
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.84671681
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84244527
158IGF1R_20145208_ChIP-Seq_DFB_Human0.83634674
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83042226
160NANOG_18555785_Chip-Seq_ESCs_Mouse0.81653084
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80446680
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.80411496
163TP53_16413492_ChIP-PET_HCT116_Human0.80239633
164REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79583104
165SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79321062
166AR_19668381_ChIP-Seq_PC3_Human0.79122333
167SOX9_26525672_Chip-Seq_HEART_Mouse0.78938318
168EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78741846
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78675093
170EP300_21415370_ChIP-Seq_HL-1_Mouse0.78665253
171HTT_18923047_ChIP-ChIP_STHdh_Human0.78146682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.78546198
2MP0003880_abnormal_central_pattern4.58594222
3MP0003635_abnormal_synaptic_transmissio3.37102637
4MP0004270_analgesia2.86234316
5MP0009745_abnormal_behavioral_response2.85285277
6MP0005670_abnormal_white_adipose2.76888164
7MP0004215_abnormal_myocardial_fiber2.60301976
8MP0009046_muscle_twitch2.59229250
9MP0000678_abnormal_parathyroid_gland2.55630630
10MP0002064_seizures2.53127141
11MP0002063_abnormal_learning/memory/cond2.52000062
12MP0005423_abnormal_somatic_nervous2.49145373
13MP0001486_abnormal_startle_reflex2.44312780
14MP0002272_abnormal_nervous_system2.44300973
15MP0002822_catalepsy2.39192119
16MP0002734_abnormal_mechanical_nocicepti2.21136208
17MP0002572_abnormal_emotion/affect_behav2.17201513
18MP0001968_abnormal_touch/_nociception2.13248244
19MP0004043_abnormal_pH_regulation2.10536503
20MP0001529_abnormal_vocalization2.07524546
21MP0000751_myopathy2.05580427
22MP0004145_abnormal_muscle_electrophysio2.04010548
23MP0001440_abnormal_grooming_behavior2.00197569
24MP0002837_dystrophic_cardiac_calcinosis1.96278464
25MP0001501_abnormal_sleep_pattern1.95319674
26MP0004019_abnormal_vitamin_homeostasis1.76597513
27MP0001986_abnormal_taste_sensitivity1.74979803
28MP0004130_abnormal_muscle_cell1.66026099
29MP0002067_abnormal_sensory_capabilities1.65505561
30MP0005666_abnormal_adipose_tissue1.64729392
31MP0000566_synostosis1.63717069
32MP0001485_abnormal_pinna_reflex1.61792995
33MP0002184_abnormal_innervation1.59578017
34MP0004885_abnormal_endolymph1.55624227
35MP0003123_paternal_imprinting1.52671034
36MP0004142_abnormal_muscle_tone1.52480423
37MP0002736_abnormal_nociception_after1.51698439
38MP0006276_abnormal_autonomic_nervous1.51001244
39MP0008569_lethality_at_weaning1.50163069
40MP0001970_abnormal_pain_threshold1.49504751
41MP0003879_abnormal_hair_cell1.49047004
42MP0002249_abnormal_larynx_morphology1.48907625
43MP0008877_abnormal_DNA_methylation1.48675465
44MP0005386_behavior/neurological_phenoty1.48070784
45MP0004924_abnormal_behavior1.48070784
46MP0002735_abnormal_chemical_nociception1.47516873
47MP0004084_abnormal_cardiac_muscle1.47385685
48MP0003137_abnormal_impulse_conducting1.46446080
49MP0003646_muscle_fatigue1.45450670
50MP0004484_altered_response_of1.40841255
51MP0005360_urolithiasis1.40127972
52MP0004036_abnormal_muscle_relaxation1.36420567
53MP0002139_abnormal_hepatobiliary_system1.34696886
54MP0002733_abnormal_thermal_nociception1.34557655
55MP0000778_abnormal_nervous_system1.33339102
56MP0006036_abnormal_mitochondrial_physio1.32724875
57MP0002557_abnormal_social/conspecific_i1.31834521
58MP0004510_myositis1.29375146
59MP0002876_abnormal_thyroid_physiology1.28143549
60MP0001905_abnormal_dopamine_level1.27887525
61MP0010329_abnormal_lipoprotein_level1.27309946
62MP0003329_amyloid_beta_deposits1.26781391
63MP0002909_abnormal_adrenal_gland1.24552835
64MP0005365_abnormal_bile_salt1.22717722
65MP0002066_abnormal_motor_capabilities/c1.22368230
66MP0004085_abnormal_heartbeat1.21937889
67MP0009780_abnormal_chondrocyte_physiolo1.20487767
68MP0005375_adipose_tissue_phenotype1.20477037
69MP0001765_abnormal_ion_homeostasis1.20188815
70MP0001188_hyperpigmentation1.19378439
71MP0003690_abnormal_glial_cell1.19215981
72MP0001984_abnormal_olfaction1.18211517
73MP0005330_cardiomyopathy1.16820272
74MP0000955_abnormal_spinal_cord1.14821340
75MP0002102_abnormal_ear_morphology1.13113589
76MP0005646_abnormal_pituitary_gland1.12012477
77MP0002132_abnormal_respiratory_system1.09669464
78MP0004858_abnormal_nervous_system1.08062792
79MP0002882_abnormal_neuron_morphology1.07502404
80MP0008875_abnormal_xenobiotic_pharmacok1.05609011
81MP0003787_abnormal_imprinting1.01602959
82MP0004742_abnormal_vestibular_system1.00642447
83MP0005620_abnormal_muscle_contractility1.00292793
84MP0005464_abnormal_platelet_physiology0.99652487
85MP0004811_abnormal_neuron_physiology0.99430471
86MP0003122_maternal_imprinting0.99404096
87MP0005645_abnormal_hypothalamus_physiol0.99341338
88MP0003075_altered_response_to0.97825047
89MP0002638_abnormal_pupillary_reflex0.97787928
90MP0005166_decreased_susceptibility_to0.97327354
91MP0000747_muscle_weakness0.96354939
92MP0003183_abnormal_peptide_metabolism0.95715336
93MP0008872_abnormal_physiological_respon0.94733617
94MP0006072_abnormal_retinal_apoptosis0.94619867
95MP0003633_abnormal_nervous_system0.94522330
96MP0000013_abnormal_adipose_tissue0.94254712
97MP0001963_abnormal_hearing_physiology0.93977902
98MP0005409_darkened_coat_color0.93351575
99MP0008004_abnormal_stomach_pH0.92081436
100MP0008874_decreased_physiological_sensi0.91888064
101MP0003283_abnormal_digestive_organ0.91317294
102MP0005551_abnormal_eye_electrophysiolog0.90698630
103MP0006035_abnormal_mitochondrial_morpho0.89603976
104MP0008775_abnormal_heart_ventricle0.88405799
105MP0000681_abnormal_thyroid_gland0.88324074
106MP0000631_abnormal_neuroendocrine_gland0.87777158
107MP0005058_abnormal_lysosome_morphology0.87362005
108MP0001666_abnormal_nutrient_absorption0.87150346
109MP0002971_abnormal_brown_adipose0.86432152
110MP0002152_abnormal_brain_morphology0.86262552
111MP0002118_abnormal_lipid_homeostasis0.85827274
112MP0005187_abnormal_penis_morphology0.85710373
113MP0001346_abnormal_lacrimal_gland0.85676178
114MP0008995_early_reproductive_senescence0.85642972
115MP0002972_abnormal_cardiac_muscle0.85378698
116MP0002796_impaired_skin_barrier0.84312592
117MP0004147_increased_porphyrin_level0.83188374
118MP0002229_neurodegeneration0.82481929
119MP0009379_abnormal_foot_pigmentation0.82243989
120MP0001502_abnormal_circadian_rhythm0.81643402
121MP0002106_abnormal_muscle_physiology0.80904449
122MP0002234_abnormal_pharynx_morphology0.80352793
123MP0003315_abnormal_perineum_morphology0.80350530
124MP0003938_abnormal_ear_development0.80176486
125MP0002160_abnormal_reproductive_system0.78274704
126MP0005448_abnormal_energy_balance0.77585832
127MP0005636_abnormal_mineral_homeostasis0.77439861
128MP0005085_abnormal_gallbladder_physiolo0.77406062
129MP0005377_hearing/vestibular/ear_phenot0.77267658
130MP0003878_abnormal_ear_physiology0.77267658
131MP0002089_abnormal_postnatal_growth/wei0.75757470
132MP0006138_congestive_heart_failure0.74886369
133MP0000920_abnormal_myelination0.74840206
134MP0002752_abnormal_somatic_nervous0.74609606
135MP0005332_abnormal_amino_acid0.74598802
136MP0005369_muscle_phenotype0.73695908
137MP0003121_genomic_imprinting0.73695682
138MP0003953_abnormal_hormone_level0.72777336
139MP0001664_abnormal_digestion0.72623839
140MP0009672_abnormal_birth_weight0.71265440
141MP0000749_muscle_degeneration0.71170605
142MP0001177_atelectasis0.70586698
143MP0005535_abnormal_body_temperature0.70496483
144MP0001544_abnormal_cardiovascular_syste0.70258977
145MP0005385_cardiovascular_system_phenoty0.70258977
146MP0006292_abnormal_olfactory_placode0.69160210
147MP0010630_abnormal_cardiac_muscle0.67253401
148MP0004087_abnormal_muscle_fiber0.66717454
149MP0003631_nervous_system_phenotype0.66406874

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.82928874
2Myokymia (HP:0002411)5.11378913
3Acute necrotizing encephalopathy (HP:0006965)4.47483781
4Visual hallucinations (HP:0002367)4.26387289
5Obstructive sleep apnea (HP:0002870)4.25560461
6Abnormal mitochondria in muscle tissue (HP:0008316)4.09862963
7Focal seizures (HP:0007359)3.87842147
8Progressive macrocephaly (HP:0004481)3.86307566
9Acute encephalopathy (HP:0006846)3.63802517
10Mitochondrial inheritance (HP:0001427)3.57149650
11Ventricular fibrillation (HP:0001663)3.48199340
12Absence seizures (HP:0002121)3.41481945
13Atonic seizures (HP:0010819)3.34988103
14Broad-based gait (HP:0002136)3.26248594
15Diplopia (HP:0000651)3.16261598
16Abnormality of binocular vision (HP:0011514)3.16261598
17Truncus arteriosus (HP:0001660)3.14170630
18Increased CSF lactate (HP:0002490)3.13831241
19Generalized tonic-clonic seizures (HP:0002069)3.06318394
20Dialeptic seizures (HP:0011146)3.05688797
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99693705
22Hyperthyroidism (HP:0000836)2.99356048
23Torticollis (HP:0000473)2.97608446
24Epileptic encephalopathy (HP:0200134)2.94022715
25Progressive cerebellar ataxia (HP:0002073)2.89260960
26Hypercortisolism (HP:0001578)2.84409233
27Annular pancreas (HP:0001734)2.75013895
28Increased hepatocellular lipid droplets (HP:0006565)2.73277597
29Sudden death (HP:0001699)2.70382856
30Hepatocellular necrosis (HP:0001404)2.68488650
31Anxiety (HP:0000739)2.68216235
32Male infertility (HP:0003251)2.64769455
33Poor eye contact (HP:0000817)2.61645888
34Increased circulating renin level (HP:0000848)2.58236856
35Focal dystonia (HP:0004373)2.53400962
36Febrile seizures (HP:0002373)2.50318992
37Craniofacial dystonia (HP:0012179)2.50229824
38Muscle hypertrophy of the lower extremities (HP:0008968)2.46669310
39Dysdiadochokinesis (HP:0002075)2.45472698
40Rigidity (HP:0002063)2.44038468
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43357253
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43357253
43Myopathic facies (HP:0002058)2.42105594
44Lipid accumulation in hepatocytes (HP:0006561)2.41381821
45Metabolic alkalosis (HP:0200114)2.35764351
46Prolonged QT interval (HP:0001657)2.31133080
47Ankle clonus (HP:0011448)2.31031971
48Hepatic necrosis (HP:0002605)2.30845005
49Calf muscle hypertrophy (HP:0008981)2.30184174
50Abnormal social behavior (HP:0012433)2.28974366
51Impaired social interactions (HP:0000735)2.28974366
52Purpura (HP:0000979)2.28546132
53Action tremor (HP:0002345)2.27464180
54Syncope (HP:0001279)2.26333299
55Optic disc pallor (HP:0000543)2.25018871
56Leukodystrophy (HP:0002415)2.24695577
57Gaze-evoked nystagmus (HP:0000640)2.24599618
58Heart block (HP:0012722)2.23773078
59Neuronal loss in central nervous system (HP:0002529)2.23284775
60Dysmetria (HP:0001310)2.21405300
61Respiratory failure (HP:0002878)2.21337705
62Adrenal overactivity (HP:0002717)2.21274138
63Progressive inability to walk (HP:0002505)2.20981588
64Lip pit (HP:0100267)2.20482448
65Mutism (HP:0002300)2.20448581
66Increased intramyocellular lipid droplets (HP:0012240)2.18755330
67Hyperventilation (HP:0002883)2.18294588
68Cerebral edema (HP:0002181)2.17842564
69Abnormal EKG (HP:0003115)2.17025987
70Hyperlipoproteinemia (HP:0010980)2.15546246
71Lactic acidosis (HP:0003128)2.14374233
72X-linked dominant inheritance (HP:0001423)2.13555342
73Bundle branch block (HP:0011710)2.11340102
74Sleep apnea (HP:0010535)2.10336374
75Testicular atrophy (HP:0000029)2.10027022
76Bradykinesia (HP:0002067)2.08253592
77Exercise-induced myalgia (HP:0003738)2.07557089
78Abnormal atrioventricular conduction (HP:0005150)2.05625005
79Exercise intolerance (HP:0003546)2.04534233
80Dysmetric saccades (HP:0000641)2.04511763
81Tetraplegia (HP:0002445)2.04488762
82Hyperphosphatemia (HP:0002905)2.03815607
83Tetany (HP:0001281)2.02824840
84Hyperactive renin-angiotensin system (HP:0000841)2.01644123
85Unsteady gait (HP:0002317)2.01220766
86Prolonged bleeding time (HP:0003010)2.01212594
87Impaired vibration sensation in the lower limbs (HP:0002166)2.01065321
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00738337
89Dysphonia (HP:0001618)2.00637242
90Neurofibrillary tangles (HP:0002185)2.00385378
91Ileus (HP:0002595)1.97857316
92Congenital malformation of the right heart (HP:0011723)1.97305700
93Double outlet right ventricle (HP:0001719)1.97305700
94Renal Fanconi syndrome (HP:0001994)1.96848217
95Delusions (HP:0000746)1.96666549
96Papilledema (HP:0001085)1.95082541
97Abnormal eating behavior (HP:0100738)1.94914952
98Nasolacrimal duct obstruction (HP:0000579)1.94579889
99Split foot (HP:0001839)1.93955570
100Pheochromocytoma (HP:0002666)1.93126285
101Hypokalemic alkalosis (HP:0001949)1.92639429
102Cerebral inclusion bodies (HP:0100314)1.92416364
103Increased purine levels (HP:0004368)1.90640224
104Hyperuricemia (HP:0002149)1.90640224
105Hyperparathyroidism (HP:0000843)1.90176102
106Fetal akinesia sequence (HP:0001989)1.88363273
107Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87750256
108Ragged-red muscle fibers (HP:0003200)1.87712344
109Hypomagnesemia (HP:0002917)1.87613594
110Periauricular skin pits (HP:0100277)1.85396595
111Preauricular pit (HP:0004467)1.85396595
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85278826
113Abnormality of alanine metabolism (HP:0010916)1.85278826
114Hyperalaninemia (HP:0003348)1.85278826
115Status epilepticus (HP:0002133)1.85081703
116Retinal dysplasia (HP:0007973)1.84431754
117Depression (HP:0000716)1.84213739
118Transposition of the great arteries (HP:0001669)1.84141361
119Abnormal connection of the cardiac segments (HP:0011545)1.84141361
120Abnormal ventriculo-arterial connection (HP:0011563)1.84141361
121Muscle stiffness (HP:0003552)1.84078967
122Atrial fibrillation (HP:0005110)1.83817219
123Urinary urgency (HP:0000012)1.82758270
124Hemiparesis (HP:0001269)1.81896479
125Neuroendocrine neoplasm (HP:0100634)1.81158791
126Stereotypic behavior (HP:0000733)1.80921484
127Increased muscle lipid content (HP:0009058)1.80276152
128Abnormality of the calf musculature (HP:0001430)1.79872517
129Growth hormone excess (HP:0000845)1.79087951
130Choreoathetosis (HP:0001266)1.78857262
131Drooling (HP:0002307)1.76977159
132Excessive salivation (HP:0003781)1.76977159
133Primary atrial arrhythmia (HP:0001692)1.76197756
134Limb dystonia (HP:0002451)1.76044235
135Skin pits (HP:0100276)1.75496552
136Abnormality of the salivary glands (HP:0010286)1.75164028
137Muscle fiber splitting (HP:0003555)1.74863940
138Deep venous thrombosis (HP:0002625)1.73813419
139Ventricular arrhythmia (HP:0004308)1.72550288
140Athetosis (HP:0002305)1.72483750
141Supraventricular tachycardia (HP:0004755)1.71985914
142Peripheral hypomyelination (HP:0007182)1.71847931
143Bowel incontinence (HP:0002607)1.71431467
144Increased serum lactate (HP:0002151)1.71330394
145Renal salt wasting (HP:0000127)1.71136174
146Stridor (HP:0010307)1.71105923
147Inability to walk (HP:0002540)1.69707274
148Gout (HP:0001997)1.68865653
149Abnormality of saccadic eye movements (HP:0000570)1.68804688
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68616616
151Truncal ataxia (HP:0002078)1.68253710
152Hyporeflexia of lower limbs (HP:0002600)1.68019678
153Hypoplastic left heart (HP:0004383)1.67734445
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67026265
155Cerebral hypomyelination (HP:0006808)1.66103228
156Abnormality of cells of the erythroid lineage (HP:0012130)1.64408521
157Respiratory difficulties (HP:0002880)1.63618043
158Urinary bladder sphincter dysfunction (HP:0002839)1.62921548
159Supraventricular arrhythmia (HP:0005115)1.62597517
160Supranuclear gaze palsy (HP:0000605)1.62415566
161Postural instability (HP:0002172)1.61593892
162Hyperaldosteronism (HP:0000859)1.61508518
163Abnormality of renin-angiotensin system (HP:0000847)1.59883254
164Spastic gait (HP:0002064)1.59442496
165Abnormality of magnesium homeostasis (HP:0004921)1.58646048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.05976410
2NTRK33.52551294
3MARK12.62136276
4MAP3K92.58000425
5PRPF4B2.52525040
6MAP3K42.41075910
7PNCK2.34877260
8RIPK12.30396653
9NME12.18209460
10CDK122.17851898
11OXSR12.08488027
12MAP2K72.08376444
13NEK12.03260819
14MINK11.99443525
15ERN11.90862576
16TNIK1.79837620
17WNK41.79336670
18STK391.76096581
19TRIB31.76074485
20PAK61.74844113
21MAPK121.72630079
22WNK31.69474136
23NME21.66914346
24NTRK21.54842126
25RIPK41.54556717
26PRKD31.51773540
27TNK21.48171227
28MAP2K41.41673927
29CDK191.36206823
30DAPK21.35537631
31PLK21.33567955
32BMX1.32156468
33SIK11.31583613
34PHKG21.31103075
35PHKG11.31103075
36LATS21.30431329
37MUSK1.30047601
38ARAF1.25826105
39PDK11.25078619
40PRKCG1.24004241
41STK161.23341103
42MAP3K121.23302758
43CDK51.23165643
44KSR21.23163970
45CAMKK11.20367005
46PINK11.19661582
47WEE11.19344407
48MAPK131.17486634
49MARK21.16503037
50BRSK11.13650923
51PDK41.12354641
52PDK31.12354641
53LRRK21.12255165
54CAMK2A1.10095494
55OBSCN1.08622886
56UHMK11.07764046
57MAPK151.07657954
58CAMK2B1.06382148
59KSR11.03298209
60LMTK21.03275308
61TYRO31.01273079
62PAK30.99427781
63NTRK10.99256119
64SMG10.98177106
65CAMKK20.96578060
66CAMK10.94935275
67GRK50.94914815
68ICK0.92781393
69CAMK2D0.91635872
70PTK20.91406879
71STK110.90858068
72NEK60.90247598
73CASK0.89683363
74MAPKAPK30.89609479
75STK380.89556477
76MAP3K10.89356560
77TAOK20.86987427
78WNK10.86040012
79MAP2K60.85233467
80MAP2K20.84079909
81DYRK1A0.82623054
82CCNB10.80930455
83CDK140.80864644
84DAPK10.80840943
85PRKG20.79323759
86CDK150.77482807
87CAMK2G0.76704858
88EPHA20.75604707
89BUB10.75598218
90CDK180.75052862
91CDK11A0.74124522
92CSNK1G20.73738106
93BMPR20.70758801
94MKNK20.70583151
95STK240.68329467
96RAF10.67672003
97BCR0.67526980
98PRKCE0.66365295
99RET0.66058317
100MAP2K10.65644270
101PRKD10.65442690
102ILK0.64989854
103SIK20.64129871
104PLK30.64085776
105MAP3K70.62925383
106PAK10.62355653
107BRAF0.60386484
108CSNK1E0.58695960
109PDK20.58670703
110PIK3CA0.58066119
111GRK70.57852436
112FES0.57780526
113MYLK0.57650885
114PBK0.57513400
115PRKCH0.56899393
116ABL20.55891162
117BRSK20.54836382
118CDC70.54805618
119MAP3K20.53968154
120CDC42BPA0.53190756
121PRKACA0.52463359
122CSNK1G30.52346866
123MKNK10.50101966
124SGK10.49742594
125PTK2B0.49460787
126CSNK1A1L0.49129554
127AKT20.47076438
128PRKD20.46879576
129MTOR0.46580002
130PRKG10.45855981
131FGFR40.43665111
132CDK30.42709574
133EIF2AK10.42699169
134RPS6KA30.42690936
135ALK0.42548045
136MAPK100.42395979
137PKN10.42207099
138TAOK10.40104151
139PDPK10.40041958
140MAP3K130.38931862
141AURKA0.38565293
142MAPK110.38554553
143TESK10.36806098
144DMPK0.36751534
145GSK3B0.36651785

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69465508
2Oxidative phosphorylation_Homo sapiens_hsa001903.56888105
3Parkinsons disease_Homo sapiens_hsa050123.23140139
4Cardiac muscle contraction_Homo sapiens_hsa042603.14893278
5Vitamin B6 metabolism_Homo sapiens_hsa007502.86865056
6Alzheimers disease_Homo sapiens_hsa050102.61769083
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52358540
8GABAergic synapse_Homo sapiens_hsa047272.51699771
9Huntingtons disease_Homo sapiens_hsa050162.41504345
10Circadian entrainment_Homo sapiens_hsa047132.33222338
11Glutamatergic synapse_Homo sapiens_hsa047242.33198306
12Long-term potentiation_Homo sapiens_hsa047202.25563918
13Synaptic vesicle cycle_Homo sapiens_hsa047212.25433077
14Morphine addiction_Homo sapiens_hsa050322.22289925
15Amphetamine addiction_Homo sapiens_hsa050312.14134322
16Olfactory transduction_Homo sapiens_hsa047402.11211905
17Salivary secretion_Homo sapiens_hsa049701.91514335
18Phenylalanine metabolism_Homo sapiens_hsa003601.91503986
19Taste transduction_Homo sapiens_hsa047421.86953265
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80370568
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78262829
22Dopaminergic synapse_Homo sapiens_hsa047281.77928718
23Gastric acid secretion_Homo sapiens_hsa049711.76722072
24Insulin secretion_Homo sapiens_hsa049111.76005387
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70843564
26Arginine and proline metabolism_Homo sapiens_hsa003301.70498780
27Calcium signaling pathway_Homo sapiens_hsa040201.67674932
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56283570
29Arginine biosynthesis_Homo sapiens_hsa002201.51799844
30Serotonergic synapse_Homo sapiens_hsa047261.51014744
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50770459
32Histidine metabolism_Homo sapiens_hsa003401.49856743
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47500282
34Cholinergic synapse_Homo sapiens_hsa047251.46614366
35Oxytocin signaling pathway_Homo sapiens_hsa049211.45177662
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44167491
37Sulfur relay system_Homo sapiens_hsa041221.41871367
38Long-term depression_Homo sapiens_hsa047301.41190413
39Renin secretion_Homo sapiens_hsa049241.37942566
40Collecting duct acid secretion_Homo sapiens_hsa049661.37868055
41RNA polymerase_Homo sapiens_hsa030201.34526111
42Oocyte meiosis_Homo sapiens_hsa041141.31372144
43Proteasome_Homo sapiens_hsa030501.26831194
44Cocaine addiction_Homo sapiens_hsa050301.25139778
45Tyrosine metabolism_Homo sapiens_hsa003501.15399180
46Folate biosynthesis_Homo sapiens_hsa007901.14786804
47Dilated cardiomyopathy_Homo sapiens_hsa054141.13805827
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11591477
49cAMP signaling pathway_Homo sapiens_hsa040241.08910326
50Gap junction_Homo sapiens_hsa045401.03857632
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03742087
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02274682
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01869299
54GnRH signaling pathway_Homo sapiens_hsa049121.00495207
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98793534
56Prion diseases_Homo sapiens_hsa050200.98362332
57beta-Alanine metabolism_Homo sapiens_hsa004100.95155998
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.92037875
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.90932620
60Ribosome_Homo sapiens_hsa030100.89136336
61Pancreatic secretion_Homo sapiens_hsa049720.88893394
62Melanogenesis_Homo sapiens_hsa049160.84929690
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83886206
64PPAR signaling pathway_Homo sapiens_hsa033200.82508284
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82253745
66Butanoate metabolism_Homo sapiens_hsa006500.81224956
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80629747
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79695869
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79009974
70Thyroid hormone synthesis_Homo sapiens_hsa049180.77189302
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75375008
72Phototransduction_Homo sapiens_hsa047440.75191033
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72857644
74Axon guidance_Homo sapiens_hsa043600.70896173
75Vibrio cholerae infection_Homo sapiens_hsa051100.69952457
76Insulin signaling pathway_Homo sapiens_hsa049100.67789376
77Purine metabolism_Homo sapiens_hsa002300.67040380
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66497953
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64535523
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.61484963
81Retinol metabolism_Homo sapiens_hsa008300.58424068
82Estrogen signaling pathway_Homo sapiens_hsa049150.58082321
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57532868
84Fat digestion and absorption_Homo sapiens_hsa049750.56309327
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53407578
86Nitrogen metabolism_Homo sapiens_hsa009100.51306916
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51083591
88Chemical carcinogenesis_Homo sapiens_hsa052040.48372076
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47582318
90Mineral absorption_Homo sapiens_hsa049780.46977086
91VEGF signaling pathway_Homo sapiens_hsa043700.46478490
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44880008
93Ovarian steroidogenesis_Homo sapiens_hsa049130.44873148
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.44628421
95AMPK signaling pathway_Homo sapiens_hsa041520.44074839
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.42474731
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42373206
98Type II diabetes mellitus_Homo sapiens_hsa049300.42344770
99Propanoate metabolism_Homo sapiens_hsa006400.42323468
100Linoleic acid metabolism_Homo sapiens_hsa005910.41536072
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41195945
102Vitamin digestion and absorption_Homo sapiens_hsa049770.41033269
103Tight junction_Homo sapiens_hsa045300.40545816
104Arachidonic acid metabolism_Homo sapiens_hsa005900.40512160
105Circadian rhythm_Homo sapiens_hsa047100.39631401
106Dorso-ventral axis formation_Homo sapiens_hsa043200.39577265
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39527650
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37701825
109Glucagon signaling pathway_Homo sapiens_hsa049220.37473278
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37400767
111Basal transcription factors_Homo sapiens_hsa030220.36403486
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.36242887
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36102258
114Pyrimidine metabolism_Homo sapiens_hsa002400.35480817
115Spliceosome_Homo sapiens_hsa030400.34556241
116Bile secretion_Homo sapiens_hsa049760.33501721
117Choline metabolism in cancer_Homo sapiens_hsa052310.32915326
118Wnt signaling pathway_Homo sapiens_hsa043100.32850506
119RNA transport_Homo sapiens_hsa030130.31979445
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31424462
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31141249
122ErbB signaling pathway_Homo sapiens_hsa040120.28942817
123Hedgehog signaling pathway_Homo sapiens_hsa043400.27130215
124Metabolic pathways_Homo sapiens_hsa011000.26913058
125Protein export_Homo sapiens_hsa030600.26782025
126Ether lipid metabolism_Homo sapiens_hsa005650.25964058
127Glioma_Homo sapiens_hsa052140.25491325
128Fatty acid elongation_Homo sapiens_hsa000620.24390363
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23753830
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23646031
131RNA degradation_Homo sapiens_hsa030180.23314122
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23298792
133Carbon metabolism_Homo sapiens_hsa012000.22892840

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