MSX2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.23534241
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.17973352
3histone H4-K12 acetylation (GO:0043983)6.14578498
4antigen processing and presentation of endogenous antigen (GO:0019883)5.77254578
5regulation of posttranscriptional gene silencing (GO:0060147)5.72927447
6regulation of gene silencing by miRNA (GO:0060964)5.72927447
7regulation of gene silencing by RNA (GO:0060966)5.72927447
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.54736358
9negative regulation of gene silencing (GO:0060969)5.23812468
10fatty acid elongation (GO:0030497)4.95099391
11negative regulation of cell killing (GO:0031342)4.85884683
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85884683
13positive regulation of hair follicle development (GO:0051798)4.63817870
14positive regulation of hair cycle (GO:0042635)4.63817870
15mast cell activation (GO:0045576)4.61494242
16sperm capacitation (GO:0048240)4.57800764
17positive regulation of natural killer cell mediated immunity (GO:0002717)4.32917998
18protein-chromophore linkage (GO:0018298)4.32045231
19response to pheromone (GO:0019236)4.30290306
20regulation of natural killer cell mediated immunity (GO:0002715)4.25679812
21regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.25679812
22multicellular organism reproduction (GO:0032504)4.22419147
23positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.18761277
24cellular response to interleukin-15 (GO:0071350)4.15793822
25rhodopsin mediated signaling pathway (GO:0016056)4.11374226
26positive regulation of gamma-delta T cell activation (GO:0046645)4.08620821
27negative T cell selection (GO:0043383)4.08487695
28positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.04959927
29positive T cell selection (GO:0043368)4.01514076
30regulation of DNA damage checkpoint (GO:2000001)3.97564334
31mast cell degranulation (GO:0043303)3.97317446
32mast cell activation involved in immune response (GO:0002279)3.97317446
33autophagic vacuole fusion (GO:0000046)3.89470503
34regulation of leukocyte mediated cytotoxicity (GO:0001910)3.86881641
35thrombin receptor signaling pathway (GO:0070493)3.84031116
36negative thymic T cell selection (GO:0045060)3.80286093
37positive regulation of T cell mediated cytotoxicity (GO:0001916)3.71883355
38regulation of T cell mediated cytotoxicity (GO:0001914)3.70196173
39leukocyte aggregation (GO:0070486)3.67773534
40response to interleukin-15 (GO:0070672)3.62879688
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.62419967
42positive regulation of cell killing (GO:0031343)3.61368607
43regulation of gamma-delta T cell differentiation (GO:0045586)3.59206676
44T cell migration (GO:0072678)3.57830173
45regulation of cell killing (GO:0031341)3.48150838
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46929029
47response to interferon-beta (GO:0035456)3.43055810
48negative regulation of T cell mediated immunity (GO:0002710)3.42018083
49regulation of regulatory T cell differentiation (GO:0045589)3.41955397
50microglial cell activation (GO:0001774)3.40335198
51positive thymic T cell selection (GO:0045059)3.39499494
52regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.37886236
53NIK/NF-kappaB signaling (GO:0038061)3.36960445
54positive regulation of granulocyte differentiation (GO:0030854)3.36921296
55ubiquinone biosynthetic process (GO:0006744)3.34468079
56tooth mineralization (GO:0034505)3.33904608
57respiratory burst (GO:0045730)3.20256639
58positive regulation of interleukin-17 production (GO:0032740)3.20178808
59membrane tubulation (GO:0097320)3.18280740
60myoblast migration (GO:0051451)3.17986489
61regulation of hair follicle development (GO:0051797)3.17050477
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.15743274
63DNA damage response, detection of DNA damage (GO:0042769)3.15068896
64cytidine catabolic process (GO:0006216)3.12227321
65cytidine deamination (GO:0009972)3.12227321
66cytidine metabolic process (GO:0046087)3.12227321
67T cell selection (GO:0045058)3.11446668
68organelle membrane fusion (GO:0090174)3.10364586
69thymic T cell selection (GO:0045061)3.10153513
70regulation of gamma-delta T cell activation (GO:0046643)3.09550148
71histone H3-K36 demethylation (GO:0070544)3.09153189
72positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.08584450
73actin nucleation (GO:0045010)3.07674039
74positive regulation of interleukin-4 production (GO:0032753)3.06553721
75positive regulation of interleukin-8 secretion (GO:2000484)3.04244779
76skeletal muscle tissue regeneration (GO:0043403)3.04167245
77myeloid cell activation involved in immune response (GO:0002275)2.96101899
78cellular defense response (GO:0006968)2.95000636
79female mating behavior (GO:0060180)2.94563478
80regulation of alpha-beta T cell proliferation (GO:0046640)2.93302577
81ribosomal small subunit assembly (GO:0000028)2.93232111
82leukocyte degranulation (GO:0043299)2.90085341
83macrophage activation involved in immune response (GO:0002281)2.89159954
84macrophage chemotaxis (GO:0048246)2.87892605
85negative regulation of T cell apoptotic process (GO:0070233)2.84869489
86bone trabecula formation (GO:0060346)2.80897832
87ubiquinone metabolic process (GO:0006743)2.79094490
88regulation of T cell mediated immunity (GO:0002709)2.78972592
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78573133
90regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78197544
91cellular extravasation (GO:0045123)2.77772512
92regulation of B cell differentiation (GO:0045577)2.77482110
93regulation of female receptivity (GO:0045924)2.77035075
94epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.76499825
95positive regulation of T cell mediated immunity (GO:0002711)2.75747196
96regulation of B cell receptor signaling pathway (GO:0050855)2.75455180
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.74484086
98regulation of gene silencing (GO:0060968)2.73309587
99reproduction (GO:0000003)2.72735944
100DNA deamination (GO:0045006)2.70762628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.39537713
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.17914790
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98128667
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.82646012
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.72560619
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51574275
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.13033053
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.05342978
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94846462
10RUNX_20019798_ChIP-Seq_JUKART_Human2.83725270
11MYB_26560356_Chip-Seq_TH2_Human2.60458685
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.56177699
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54345623
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46015049
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45650459
16SCL_19346495_ChIP-Seq_HPC-7_Human2.44187311
17UTX_26944678_Chip-Seq_JUKART_Human2.30191907
18MYB_26560356_Chip-Seq_TH1_Human2.27997442
19MAF_26560356_Chip-Seq_TH1_Human2.22602335
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12686248
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10140965
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08003986
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98346206
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.92398003
25CIITA_25753668_ChIP-Seq_RAJI_Human1.89527428
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89352194
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88936982
28BCL6_27268052_Chip-Seq_Bcells_Human1.86221664
29GATA3_26560356_Chip-Seq_TH2_Human1.85178571
30SPI1_23547873_ChIP-Seq_NB4_Human1.83604890
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79814164
32GATA3_27048872_Chip-Seq_THYMUS_Human1.79292341
33GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.70780608
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.62769670
35EGR1_19032775_ChIP-ChIP_M12_Human1.57153933
36MAF_26560356_Chip-Seq_TH2_Human1.52853777
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51867505
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.51120449
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47108200
40SPI1_20517297_ChIP-Seq_HL60_Human1.41060120
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40668256
42BCOR_27268052_Chip-Seq_Bcells_Human1.40129881
43VDR_23849224_ChIP-Seq_CD4+_Human1.39372023
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.38640047
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34447016
46RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.32447360
47ZNF274_21170338_ChIP-Seq_K562_Hela1.32435787
48P300_27268052_Chip-Seq_Bcells_Human1.31337412
49SA1_27219007_Chip-Seq_Bcells_Human1.28876790
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28286503
51AR_20517297_ChIP-Seq_VCAP_Human1.27741725
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.27560563
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.26281742
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.23067989
55VDR_21846776_ChIP-Seq_THP-1_Human1.22492795
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19198236
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18775910
58NANOG_20526341_ChIP-Seq_ESCs_Human1.18151701
59EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15854794
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15530879
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14115680
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14030841
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12421784
64VDR_24763502_ChIP-Seq_THP-1_Human1.10759561
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.10262087
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.09355482
67SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.08665411
68E2F1_20622854_ChIP-Seq_HELA_Human1.08433732
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06893841
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05092388
71CTCF_20526341_ChIP-Seq_ESCs_Human1.04979440
72GATA1_19941826_ChIP-Seq_K562_Human1.03694485
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02056027
74FOXP3_21729870_ChIP-Seq_TREG_Human1.00759989
75CTCF_26484167_Chip-Seq_Bcells_Mouse0.98754520
76CTCF_27219007_Chip-Seq_Bcells_Human0.96256146
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95251563
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94592732
79SPI1_23127762_ChIP-Seq_K562_Human0.94588488
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93314035
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92985701
82BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91286544
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91072815
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90860449
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90632051
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90632051
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90632051
88MYC_22102868_ChIP-Seq_BL_Human0.89375554
89STAT1_20625510_ChIP-Seq_HELA_Human0.89091691
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89022619
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88765957
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86714981
93CTCF_21964334_Chip-Seq_Bcells_Human0.85572638
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85502466
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83648440
96MYC_18940864_ChIP-ChIP_HL60_Human0.83539662
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83477523
98TAF2_19829295_ChIP-Seq_ESCs_Human0.83235826
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82959312
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82837132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex5.53480287
2MP0005671_abnormal_response_to4.67889200
3MP0003787_abnormal_imprinting4.14473953
4MP0003436_decreased_susceptibility_to3.61373597
5MP0009333_abnormal_splenocyte_physiolog3.23986457
6MP0003724_increased_susceptibility_to3.11762814
7MP0001835_abnormal_antigen_presentation2.83412671
8MP0009785_altered_susceptibility_to2.83273637
9MP0008260_abnormal_autophagy2.79759803
10MP0006082_CNS_inflammation2.65308325
11MP0005025_abnormal_response_to2.63654838
12MP0003763_abnormal_thymus_physiology2.61937262
13MP0005464_abnormal_platelet_physiology2.61606069
14MP0005000_abnormal_immune_tolerance2.54812553
15MP0002420_abnormal_adaptive_immunity2.26720245
16MP0001819_abnormal_immune_cell2.23532052
17MP0002723_abnormal_immune_serum2.23026486
18MP0001800_abnormal_humoral_immune2.19123827
19MP0002148_abnormal_hypersensitivity_rea2.18066595
20MP0000685_abnormal_immune_system2.12115528
21MP0001764_abnormal_homeostasis2.10503382
22MP0002419_abnormal_innate_immunity2.07746445
23MP0000372_irregular_coat_pigmentation2.06340429
24MP0003191_abnormal_cellular_cholesterol2.05900426
25MP0005075_abnormal_melanosome_morpholog2.01062524
26MP0008877_abnormal_DNA_methylation1.91185376
27MP0002452_abnormal_antigen_presenting1.90552219
28MP0002398_abnormal_bone_marrow1.89506938
29MP0000716_abnormal_immune_system1.84117078
30MP0000465_gastrointestinal_hemorrhage1.83285366
31MP0010155_abnormal_intestine_physiology1.69193824
32MP0004185_abnormal_adipocyte_glucose1.62808392
33MP0000703_abnormal_thymus_morphology1.62124394
34MP0001533_abnormal_skeleton_physiology1.61430548
35MP0003646_muscle_fatigue1.58346438
36MP0000689_abnormal_spleen_morphology1.58012563
37MP0008004_abnormal_stomach_pH1.57451936
38MP0002722_abnormal_immune_system1.55710505
39MP0004142_abnormal_muscle_tone1.54790770
40MP0002132_abnormal_respiratory_system1.48739885
41MP0003303_peritoneal_inflammation1.48553400
42MP0004947_skin_inflammation1.44999218
43MP0002429_abnormal_blood_cell1.43787371
44MP0005387_immune_system_phenotype1.37563109
45MP0001790_abnormal_immune_system1.37563109
46MP0003806_abnormal_nucleotide_metabolis1.35090759
47MP0002405_respiratory_system_inflammati1.32622520
48MP0001845_abnormal_inflammatory_respons1.30423222
49MP0001545_abnormal_hematopoietic_system1.22681188
50MP0005397_hematopoietic_system_phenotyp1.22681188
51MP0002933_joint_inflammation1.18261634
52MP0003866_abnormal_defecation1.18204931
53MP0005646_abnormal_pituitary_gland1.13256862
54MP0004510_myositis1.11954397
55MP0005166_decreased_susceptibility_to1.09826688
56MP0002822_catalepsy1.08679139
57MP0002019_abnormal_tumor_incidence1.04754132
58MP0003567_abnormal_fetal_cardiomyocyte1.03910325
59MP0008469_abnormal_protein_level0.99985572
60MP0009278_abnormal_bone_marrow0.99811862
61MP0002166_altered_tumor_susceptibility0.97591112
62MP0000858_altered_metastatic_potential0.96377957
63MP0001188_hyperpigmentation0.95937733
64MP0001968_abnormal_touch/_nociception0.95699196
65MP0001919_abnormal_reproductive_system0.92142798
66MP0009763_increased_sensitivity_to0.91743562
67MP0001851_eye_inflammation0.91520648
68MP0004043_abnormal_pH_regulation0.91029682
69MP0008872_abnormal_physiological_respon0.90211133
70MP0005253_abnormal_eye_physiology0.89123953
71MP0003690_abnormal_glial_cell0.89070421
72MP0003045_fibrosis0.87030252
73MP0004883_abnormal_blood_vessel0.84706991
74MP0001661_extended_life_span0.83630550
75MP0000750_abnormal_muscle_regeneration0.83285891
76MP0005410_abnormal_fertilization0.81237461
77MP0001986_abnormal_taste_sensitivity0.80978365
78MP0000490_abnormal_crypts_of0.79512186
79MP0002396_abnormal_hematopoietic_system0.78977274
80MP0001502_abnormal_circadian_rhythm0.77210947
81MP0008875_abnormal_xenobiotic_pharmacok0.76740379
82MP0005645_abnormal_hypothalamus_physiol0.76110508
83MP0009764_decreased_sensitivity_to0.74876891
84MP0001663_abnormal_digestive_system0.74685655
85MP0004808_abnormal_hematopoietic_stem0.74110115
86MP0003123_paternal_imprinting0.72676752
87MP0005376_homeostasis/metabolism_phenot0.72655455
88MP0008873_increased_physiological_sensi0.71527232
89MP0000230_abnormal_systemic_arterial0.70144425
90MP0002006_tumorigenesis0.70126266
91MP0005310_abnormal_salivary_gland0.69637202
92MP0008874_decreased_physiological_sensi0.69063096
93MP0004019_abnormal_vitamin_homeostasis0.66150920
94MP0004381_abnormal_hair_follicle0.65417501
95MP0005389_reproductive_system_phenotype0.64480071
96MP0001873_stomach_inflammation0.64251546
97MP0005390_skeleton_phenotype0.64245657
98MP0001905_abnormal_dopamine_level0.63078020
99MP0002998_abnormal_bone_remodeling0.62473408
100MP0003121_genomic_imprinting0.59733465

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.04832514
2Abnormality of T cell number (HP:0011839)4.50291040
3Elevated erythrocyte sedimentation rate (HP:0003565)3.91851500
4IgG deficiency (HP:0004315)3.73915607
5Congenital stationary night blindness (HP:0007642)3.71555394
6Constricted visual fields (HP:0001133)3.58774689
7Hyperlipoproteinemia (HP:0010980)3.54132123
8Decreased electroretinogram (ERG) amplitude (HP:0000654)3.53673720
9Bilateral sensorineural hearing impairment (HP:0008619)3.50131920
10Abnormal rod and cone electroretinograms (HP:0008323)3.45499276
11Severe combined immunodeficiency (HP:0004430)3.43979579
12Prolonged bleeding time (HP:0003010)3.42994833
13Amyotrophic lateral sclerosis (HP:0007354)3.37149300
14Petechiae (HP:0000967)3.32766966
15Abnormality of T cells (HP:0002843)3.29263844
16Autoimmune hemolytic anemia (HP:0001890)3.16069764
17Myositis (HP:0100614)3.14268200
18Recurrent cutaneous fungal infections (HP:0011370)3.13659800
19Chronic mucocutaneous candidiasis (HP:0002728)3.13659800
20Increased IgM level (HP:0003496)3.10424912
21Abnormality of eosinophils (HP:0001879)3.01466805
22Abnormality of the parietal bone (HP:0002696)3.00274316
23Attenuation of retinal blood vessels (HP:0007843)2.95400074
24Recurrent fungal infections (HP:0002841)2.94976081
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94501699
26Pustule (HP:0200039)2.92027872
27Spontaneous hematomas (HP:0007420)2.88602029
28Encephalitis (HP:0002383)2.85756313
29Leukocytosis (HP:0001974)2.82329779
30Severe visual impairment (HP:0001141)2.80717788
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.76269086
32Scotoma (HP:0000575)2.76221405
33Retrobulbar optic neuritis (HP:0100654)2.73666619
34Optic neuritis (HP:0100653)2.73666619
35Orchitis (HP:0100796)2.70927201
36Purpura (HP:0000979)2.68826197
37Panhypogammaglobulinemia (HP:0003139)2.66548389
38Combined immunodeficiency (HP:0005387)2.63016516
39Stomach cancer (HP:0012126)2.59997754
40Granulocytopenia (HP:0001913)2.59126191
41Eczematoid dermatitis (HP:0000976)2.58304616
42Epistaxis (HP:0000421)2.56833107
43Dyschromatopsia (HP:0007641)2.56113413
44Asplenia (HP:0001746)2.53095911
45Eosinophilia (HP:0001880)2.49865186
46Agammaglobulinemia (HP:0004432)2.48488863
47Progressive microcephaly (HP:0000253)2.45584062
48Meningitis (HP:0001287)2.44237852
49Hypoplasia of the thymus (HP:0000778)2.44174387
50Keratoconjunctivitis sicca (HP:0001097)2.41612803
51Keratoconjunctivitis (HP:0001096)2.41549813
52IgM deficiency (HP:0002850)2.40571251
53Stomatitis (HP:0010280)2.39550994
54Central scotoma (HP:0000603)2.39133419
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.37489053
56Oligomenorrhea (HP:0000876)2.36559507
57Thyroiditis (HP:0100646)2.35968476
58Increased intramyocellular lipid droplets (HP:0012240)2.35742022
59Epidermoid cyst (HP:0200040)2.30291870
60Respiratory difficulties (HP:0002880)2.29758746
61Aplasia cutis congenita (HP:0001057)2.28027657
62Tinnitus (HP:0000360)2.27330247
63Gingival bleeding (HP:0000225)2.26012877
64Chronic diarrhea (HP:0002028)2.25174856
65Recurrent viral infections (HP:0004429)2.21304367
66Visual hallucinations (HP:0002367)2.18435689
67Widely patent fontanelles and sutures (HP:0004492)2.16685776
68Hypoplasia of the uterus (HP:0000013)2.13318785
69Abnormal protein glycosylation (HP:0012346)2.11440231
70Abnormal glycosylation (HP:0012345)2.11440231
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11440231
72Abnormal protein N-linked glycosylation (HP:0012347)2.11440231
73Chronic otitis media (HP:0000389)2.10219253
74Increased muscle lipid content (HP:0009058)2.07344139
75Mitochondrial inheritance (HP:0001427)2.06093780
76Cerebellar dysplasia (HP:0007033)2.02929948
77Abnormality of dentin (HP:0010299)2.00230581
78Recurrent abscess formation (HP:0002722)1.99766517
79Adactyly (HP:0009776)1.99445752
80Short clavicles (HP:0000894)1.97939060
81Episodic fever (HP:0001954)1.97240290
82Recurrent skin infections (HP:0001581)1.94853252
83Abnormality of macrophages (HP:0004311)1.94168966
84Hypoproteinemia (HP:0003075)1.94016397
85Alkalosis (HP:0001948)1.93203036
86Recurrent bacterial skin infections (HP:0005406)1.93070827
87Deep palmar crease (HP:0006191)1.92137976
88Polyneuropathy (HP:0001271)1.90677807
89Increased hepatocellular lipid droplets (HP:0006565)1.88303522
90Conical tooth (HP:0000698)1.87878566
91Premature loss of primary teeth (HP:0006323)1.87298447
92Abnormality of T cell physiology (HP:0011840)1.86436083
93Prostate neoplasm (HP:0100787)1.84966535
94Aplastic anemia (HP:0001915)1.84559062
95Chronic sinusitis (HP:0011109)1.82895169
96Hypokalemic alkalosis (HP:0001949)1.78782150
97Abnormal mitochondria in muscle tissue (HP:0008316)1.78291846
98Abolished electroretinogram (ERG) (HP:0000550)1.78168537
99Abnormal pupillary function (HP:0007686)1.77018487
100Erythema (HP:0010783)1.76880633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.97381561
2IRAK43.84812245
3MAP4K13.40815625
4TLK13.34629395
5TESK23.20120983
6MARK33.18513062
7TAF12.97328120
8TNK22.93329642
9KDR2.89421159
10SIK32.60773475
11MAP3K112.50800604
12AKT32.49761502
13SCYL22.41299207
14TXK2.40750616
15PIK3CG2.40159144
16CDK192.23486160
17IKBKE2.21693264
18MAP2K32.04741371
19KIT1.85715177
20GRK61.82962083
21PASK1.81240313
22ZAP701.78038638
23FES1.74408717
24ADRBK21.72472736
25ITK1.68408312
26MAP2K61.61657674
27BTK1.61066332
28TEC1.56949008
29ERN11.55657878
30SYK1.51699625
31PIM11.44226510
32NUAK11.40685854
33SIK21.40113849
34SIK11.29813446
35VRK21.29216704
36CSF1R1.26920515
37TAOK31.23837464
38JAK31.22439657
39VRK11.21978725
40LCK1.19004798
41MAP2K21.18579567
42RPS6KA41.11919084
43PRKCQ1.07908040
44BCKDK1.01892838
45FGR0.98497600
46ILK0.91771872
47BRAF0.91601574
48LYN0.89533912
49PRPF4B0.87862200
50TESK10.84872355
51HCK0.79923296
52NLK0.78833709
53CSK0.78460117
54GRK70.71032379
55IKBKB0.70582962
56MAPKAPK30.68789847
57LRRK20.66115570
58TBK10.65291639
59ACVR1B0.63537989
60STK110.54596592
61BLK0.54491664
62PRKCI0.48413726
63CDK80.45424012
64ARAF0.43251477
65TIE10.42586588
66MAP2K40.42128867
67TAOK20.39630010
68TYK20.35360665
69GRK10.34704199
70KSR10.34681609
71MAPK130.33406996
72CDK40.32701848
73RPS6KA50.31885596
74PRKG20.30357159
75HIPK20.29428530
76MAPK110.27727385
77PIM20.26883086
78RPS6KA60.26417296
79FYN0.24261752
80MAPK120.23529297
81MAPK30.23431381
82FLT30.22545106
83EGFR0.22045114
84MAP3K130.21930426
85SGK20.21795083
86LIMK10.21241120
87RPS6KL10.19765139
88RPS6KC10.19765139
89DAPK10.19291192
90PTK20.18797139
91PAK10.18370158
92MATK0.17338293
93ADRBK10.16028882
94STK100.15511192
95PRKCD0.14734289
96CAMKK10.14727171
97PRKACA0.13564003
98JAK10.13375324
99INSR0.12982756
100PRKCA0.12398152

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.44112679
2Graft-versus-host disease_Homo sapiens_hsa053323.17860017
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.00102884
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.82847373
5Allograft rejection_Homo sapiens_hsa053302.78458426
6Ribosome_Homo sapiens_hsa030102.64513304
7Fatty acid elongation_Homo sapiens_hsa000622.63045246
8Autoimmune thyroid disease_Homo sapiens_hsa053202.53632466
9Hematopoietic cell lineage_Homo sapiens_hsa046402.46532417
10Phototransduction_Homo sapiens_hsa047442.28704225
11Antigen processing and presentation_Homo sapiens_hsa046122.24063004
12Type I diabetes mellitus_Homo sapiens_hsa049402.11279942
13T cell receptor signaling pathway_Homo sapiens_hsa046602.10289606
14Leishmaniasis_Homo sapiens_hsa051402.07340371
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96893454
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.95195513
17RNA polymerase_Homo sapiens_hsa030201.94684581
18Regulation of autophagy_Homo sapiens_hsa041401.89046174
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87348710
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76042891
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.73964816
22Malaria_Homo sapiens_hsa051441.63425576
23Asthma_Homo sapiens_hsa053101.57600155
24Measles_Homo sapiens_hsa051621.53966477
25Oxidative phosphorylation_Homo sapiens_hsa001901.50553285
26Homologous recombination_Homo sapiens_hsa034401.46311924
27Proteasome_Homo sapiens_hsa030501.46139509
28Staphylococcus aureus infection_Homo sapiens_hsa051501.39955348
29Parkinsons disease_Homo sapiens_hsa050121.34167780
30Viral myocarditis_Homo sapiens_hsa054161.33947970
31Linoleic acid metabolism_Homo sapiens_hsa005911.32329312
32Herpes simplex infection_Homo sapiens_hsa051681.28360343
33Arachidonic acid metabolism_Homo sapiens_hsa005901.23677534
34Nitrogen metabolism_Homo sapiens_hsa009101.21241558
35Olfactory transduction_Homo sapiens_hsa047401.16005389
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14082782
37Caffeine metabolism_Homo sapiens_hsa002321.12938931
38Osteoclast differentiation_Homo sapiens_hsa043801.10737197
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10693216
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09358982
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.06418114
42Platelet activation_Homo sapiens_hsa046111.06032242
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05825904
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05365967
45Fanconi anemia pathway_Homo sapiens_hsa034601.04140432
46Chemokine signaling pathway_Homo sapiens_hsa040621.01762865
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99832431
48Tuberculosis_Homo sapiens_hsa051520.89707044
49Shigellosis_Homo sapiens_hsa051310.86091206
50Mismatch repair_Homo sapiens_hsa034300.84536422
51One carbon pool by folate_Homo sapiens_hsa006700.81397424
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80925738
53Pertussis_Homo sapiens_hsa051330.79047304
54TNF signaling pathway_Homo sapiens_hsa046680.78223245
55Peroxisome_Homo sapiens_hsa041460.77602972
56Toxoplasmosis_Homo sapiens_hsa051450.76719059
57Rheumatoid arthritis_Homo sapiens_hsa053230.76402018
58B cell receptor signaling pathway_Homo sapiens_hsa046620.71519227
59Base excision repair_Homo sapiens_hsa034100.70507825
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70377359
61Systemic lupus erythematosus_Homo sapiens_hsa053220.69987128
62Retinol metabolism_Homo sapiens_hsa008300.69408119
63DNA replication_Homo sapiens_hsa030300.66169138
64Alzheimers disease_Homo sapiens_hsa050100.65496402
65Epstein-Barr virus infection_Homo sapiens_hsa051690.65451784
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64948028
67Influenza A_Homo sapiens_hsa051640.61688953
68Pyrimidine metabolism_Homo sapiens_hsa002400.60215368
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.57755927
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55061569
71Vitamin digestion and absorption_Homo sapiens_hsa049770.53055958
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52887145
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.51825728
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51120535
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49697033
76HTLV-I infection_Homo sapiens_hsa051660.46701799
77Acute myeloid leukemia_Homo sapiens_hsa052210.45437721
78Salmonella infection_Homo sapiens_hsa051320.41154523
79Legionellosis_Homo sapiens_hsa051340.41119998
80Purine metabolism_Homo sapiens_hsa002300.40836802
81Hepatitis C_Homo sapiens_hsa051600.39721622
82Glycerolipid metabolism_Homo sapiens_hsa005610.39314963
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36139136
84Morphine addiction_Homo sapiens_hsa050320.35954185
85Huntingtons disease_Homo sapiens_hsa050160.34970906
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.34816066
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33988328
88Endocytosis_Homo sapiens_hsa041440.32958439
89Viral carcinogenesis_Homo sapiens_hsa052030.32427718
90Non-small cell lung cancer_Homo sapiens_hsa052230.32171279
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31924645
92Spliceosome_Homo sapiens_hsa030400.31364432
93Small cell lung cancer_Homo sapiens_hsa052220.30681729
94RNA degradation_Homo sapiens_hsa030180.30679172
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29965374
96Apoptosis_Homo sapiens_hsa042100.29561307
97Taste transduction_Homo sapiens_hsa047420.25740732
98Serotonergic synapse_Homo sapiens_hsa047260.23767246
99Calcium signaling pathway_Homo sapiens_hsa040200.23341195
100ABC transporters_Homo sapiens_hsa020100.22810087

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