MSX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.77127894
2translational termination (GO:0006415)6.40729857
3lateral sprouting from an epithelium (GO:0060601)5.87861437
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.23104421
5cotranslational protein targeting to membrane (GO:0006613)5.17849854
6endocardial cushion morphogenesis (GO:0003203)5.13222871
7translational elongation (GO:0006414)5.11456440
8protein targeting to ER (GO:0045047)5.09092203
9establishment of protein localization to endoplasmic reticulum (GO:0072599)4.88028999
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84397302
11cellular protein complex disassembly (GO:0043624)4.84279100
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.79637556
13* midbrain development (GO:0030901)4.77617091
14mesenchyme morphogenesis (GO:0072132)4.71149384
15protein localization to endoplasmic reticulum (GO:0070972)4.66656285
16viral life cycle (GO:0019058)4.60974364
17ribosomal small subunit assembly (GO:0000028)4.58274643
18axon extension involved in axon guidance (GO:0048846)4.51847858
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.51847858
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.47693396
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.45909100
22behavioral response to nicotine (GO:0035095)4.45153503
23sequestering of actin monomers (GO:0042989)4.42071671
24ribosomal small subunit biogenesis (GO:0042274)4.41049293
25ATP synthesis coupled proton transport (GO:0015986)4.40531884
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40531884
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.40322566
28cell migration involved in heart development (GO:0060973)4.40012946
29paraxial mesoderm development (GO:0048339)4.39852047
30dopaminergic neuron differentiation (GO:0071542)4.37669754
31outer ear morphogenesis (GO:0042473)4.37096563
32* epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.33873054
33mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.31725546
34establishment of planar polarity (GO:0001736)4.26526759
35establishment of tissue polarity (GO:0007164)4.26526759
36establishment of protein localization to mitochondrial membrane (GO:0090151)4.25664730
37maturation of SSU-rRNA (GO:0030490)4.24881456
38chondrocyte proliferation (GO:0035988)4.22397366
39otic vesicle formation (GO:0030916)4.20468912
40neuron fate determination (GO:0048664)4.17173330
41bone trabecula formation (GO:0060346)4.10502105
42notochord development (GO:0030903)4.09619139
43cochlea morphogenesis (GO:0090103)4.08399493
44sulfation (GO:0051923)4.00327547
45protein complex disassembly (GO:0043241)3.98725632
46regulation of heart morphogenesis (GO:2000826)3.95941384
47translational initiation (GO:0006413)3.93663744
48embryonic skeletal joint morphogenesis (GO:0060272)3.91464991
49* hindlimb morphogenesis (GO:0035137)3.86798275
50* embryonic forelimb morphogenesis (GO:0035115)3.83917259
51Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.82642224
52non-canonical Wnt signaling pathway (GO:0035567)3.82100330
53* forelimb morphogenesis (GO:0035136)3.81080659
54positive regulation of cartilage development (GO:0061036)3.80574748
55* embryonic hindlimb morphogenesis (GO:0035116)3.79473182
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76026471
57heart valve formation (GO:0003188)3.75672335
58macromolecular complex disassembly (GO:0032984)3.72521739
59midgut development (GO:0007494)3.71442058
60cranial suture morphogenesis (GO:0060363)3.71089133
61regulation of establishment of planar polarity (GO:0090175)3.67415141
62* middle ear morphogenesis (GO:0042474)3.60374929
63hippo signaling (GO:0035329)3.59709496
64collecting duct development (GO:0072044)3.57683548
65regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.54127127
66craniofacial suture morphogenesis (GO:0097094)3.53461278
67head development (GO:0060322)3.53077330
68embryonic cranial skeleton morphogenesis (GO:0048701)3.50566328
69positive regulation of chondrocyte differentiation (GO:0032332)3.50376486
70regulation of timing of cell differentiation (GO:0048505)3.48006603
71negative regulation of axon extension involved in axon guidance (GO:0048843)3.44927120
72embryonic digit morphogenesis (GO:0042733)3.42021176
73* regulation of mesenchymal cell apoptotic process (GO:2001053)3.38083475
74chondrocyte development (GO:0002063)3.38006724
75positive regulation of epithelial to mesenchymal transition (GO:0010718)3.35839336
76negative regulation of chondrocyte differentiation (GO:0032331)3.35519385
77electron transport chain (GO:0022900)3.35348884
78spinal cord association neuron differentiation (GO:0021527)3.35344599
79proximal/distal pattern formation (GO:0009954)3.34933330
80positive regulation of mesenchymal cell proliferation (GO:0002053)3.34886608
81protein targeting to membrane (GO:0006612)3.34654234
82negative regulation of cartilage development (GO:0061037)3.33253588
83lung-associated mesenchyme development (GO:0060484)3.32642787
84respiratory electron transport chain (GO:0022904)3.30314898
85* cell surface receptor signaling pathway involved in heart development (GO:0061311)3.29448335
86convergent extension (GO:0060026)3.22797663
87regulation of mesenchymal cell proliferation (GO:0010464)3.22066065
88* regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.21811989
89retinal ganglion cell axon guidance (GO:0031290)3.21655436
90mesenchymal cell development (GO:0014031)3.20728638
91negative regulation of embryonic development (GO:0045992)3.20142301
92* appendage morphogenesis (GO:0035107)3.19748084
93* limb morphogenesis (GO:0035108)3.19748084
94prostate gland growth (GO:0060736)3.19544720
95eyelid development in camera-type eye (GO:0061029)3.17896999
96* embryonic appendage morphogenesis (GO:0035113)3.17799237
97* embryonic limb morphogenesis (GO:0030326)3.17799237
98mesenchymal-epithelial cell signaling (GO:0060638)3.17165856
99radial glial cell differentiation (GO:0060019)3.16389664
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14884668
101somite development (GO:0061053)3.14117263
102lung epithelium development (GO:0060428)3.14061303
103positive regulation of gastrulation (GO:2000543)3.13623238
104positive regulation of smoothened signaling pathway (GO:0045880)3.12769255
105regulation of cartilage development (GO:0061035)3.11860624
106cilium movement (GO:0003341)3.11510097
107negative regulation of axon guidance (GO:1902668)3.10402217
108negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.09763588
109body morphogenesis (GO:0010171)3.08399748
110nephron tubule formation (GO:0072079)3.08336679
111polarized epithelial cell differentiation (GO:0030859)3.07956036
112eye photoreceptor cell differentiation (GO:0001754)3.07933728
113photoreceptor cell differentiation (GO:0046530)3.07933728
114cell proliferation in forebrain (GO:0021846)3.07691898
115regulation of organ formation (GO:0003156)3.06932998
116embryonic camera-type eye development (GO:0031076)3.06444534
117hematopoietic stem cell proliferation (GO:0071425)3.05231772
118forebrain neuron development (GO:0021884)3.05048978
119mitochondrial respiratory chain complex I assembly (GO:0032981)3.04283177
120NADH dehydrogenase complex assembly (GO:0010257)3.04283177
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04283177
122embryonic foregut morphogenesis (GO:0048617)3.02920628
123negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.02761248
124embryonic skeletal system morphogenesis (GO:0048704)3.02165219
125cell proliferation involved in metanephros development (GO:0072203)3.01621966
126organ induction (GO:0001759)3.00708290
127regulation of development, heterochronic (GO:0040034)3.00027580
128branching involved in salivary gland morphogenesis (GO:0060445)2.98762803
129negative regulation of epidermis development (GO:0045683)2.98456711
130negative regulation of DNA repair (GO:0045738)2.98291052
131prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.98032496
132regulation of non-canonical Wnt signaling pathway (GO:2000050)2.97001911
133postsynaptic membrane organization (GO:0001941)2.95901511
134negative regulation of catenin import into nucleus (GO:0035414)2.95643258
135limb bud formation (GO:0060174)2.94874073
136regulation of glomerulus development (GO:0090192)2.93476548
1373-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91105452
138purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91105452
139* mesenchymal cell proliferation (GO:0010463)2.89678068
140stem cell development (GO:0048864)2.88569926
141regulation of cardioblast proliferation (GO:0003264)2.86973681
142regulation of secondary heart field cardioblast proliferation (GO:0003266)2.86973681
143regulation of chondrocyte differentiation (GO:0032330)2.86509688
144nuclear-transcribed mRNA catabolic process (GO:0000956)2.86440510
145pattern specification involved in kidney development (GO:0061004)2.84893087
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.84656725
147axis elongation (GO:0003401)2.83854252
148regulation of mesoderm development (GO:2000380)2.83674646
149positive regulation of stem cell differentiation (GO:2000738)2.82576507
150spinal cord development (GO:0021510)2.82124416
151vitamin A metabolic process (GO:0006776)2.81457109
152* epithelial to mesenchymal transition (GO:0001837)2.81011978
153neural crest cell development (GO:0014032)2.80689857
154mesenchymal to epithelial transition (GO:0060231)2.80541956
155lens fiber cell development (GO:0070307)2.80444142
156mesenchyme development (GO:0060485)2.80171959
157DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.80072421
158neuron fate specification (GO:0048665)2.79887664
159protein complex biogenesis (GO:0070271)2.79008945
160musculoskeletal movement (GO:0050881)2.78001097
161multicellular organismal movement (GO:0050879)2.78001097
162embryonic body morphogenesis (GO:0010172)2.77924595
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.77699146
164central nervous system neuron development (GO:0021954)2.77567793
165positive regulation of embryonic development (GO:0040019)2.75167734
166presynaptic membrane assembly (GO:0097105)2.73924595
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72837086
168mRNA catabolic process (GO:0006402)2.70483578
169regulation of cell proliferation involved in kidney development (GO:1901722)2.69900660
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68463504
171epithelial cilium movement (GO:0003351)2.67533266
172dentate gyrus development (GO:0021542)2.65745252
173thalamus development (GO:0021794)2.63645207
174axonemal dynein complex assembly (GO:0070286)2.55140741
175transmission of nerve impulse (GO:0019226)2.54160551
176presynaptic membrane organization (GO:0097090)2.53833659
177hindbrain development (GO:0030902)2.51414030
178mitochondrial respiratory chain complex assembly (GO:0033108)2.51230851
179cell differentiation in spinal cord (GO:0021515)2.50779734
180neuronal stem cell maintenance (GO:0097150)2.50128252
181ribosomal large subunit biogenesis (GO:0042273)2.49721405
182translation (GO:0006412)2.46867085
183DNA damage response, signal transduction resulting in transcription (GO:0042772)2.45097695
184left/right pattern formation (GO:0060972)2.44883231
185positive regulation of fatty acid beta-oxidation (GO:0032000)2.44226639
186smoothened signaling pathway (GO:0007224)2.41429473
187RNA catabolic process (GO:0006401)2.40735170
188negative regulation of response to food (GO:0032096)2.39768896
189negative regulation of appetite (GO:0032099)2.39768896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.94630024
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.38256637
3EZH2_22144423_ChIP-Seq_EOC_Human4.37961326
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.72944092
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.69631588
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.20381989
7* EED_16625203_ChIP-ChIP_MESCs_Mouse3.17812488
8* EZH2_27304074_Chip-Seq_ESCs_Mouse3.13024997
9* PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.08444153
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.99619150
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.91009884
12* TP53_20018659_ChIP-ChIP_R1E_Mouse2.89700148
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.82444700
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78442776
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78442776
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.77409425
17* CBX2_27304074_Chip-Seq_ESCs_Mouse2.76633494
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61867201
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55256806
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55188801
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.52459449
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45729782
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41052848
24* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35740635
25POU5F1_16153702_ChIP-ChIP_HESCs_Human2.30772394
26* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.26790287
27VDR_22108803_ChIP-Seq_LS180_Human2.26695581
28WT1_19549856_ChIP-ChIP_CCG9911_Human2.17573894
29* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16697099
30* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.13557548
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11347696
32* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02281796
33* RING1B_27294783_Chip-Seq_NPCs_Mouse2.01148152
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95501770
35GBX2_23144817_ChIP-Seq_PC3_Human1.92771633
36FUS_26573619_Chip-Seq_HEK293_Human1.92582475
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91728723
38* RNF2_27304074_Chip-Seq_ESCs_Mouse1.89037820
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.87535558
40* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87196662
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83046542
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81718272
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81435692
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81200083
45ISL1_27105846_Chip-Seq_CPCs_Mouse1.77231920
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75504262
47* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71298997
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70932739
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70386213
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62272912
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58086368
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.57915209
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.57555001
54* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56638396
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54923076
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54476713
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54476713
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54414132
59TAF15_26573619_Chip-Seq_HEK293_Human1.52470162
60ZNF274_21170338_ChIP-Seq_K562_Hela1.49082571
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48805115
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48580537
63P300_19829295_ChIP-Seq_ESCs_Human1.46474429
64IGF1R_20145208_ChIP-Seq_DFB_Human1.42119596
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41625922
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41625922
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41625922
68* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40369049
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38906973
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36961092
71AR_21909140_ChIP-Seq_LNCAP_Human1.34693175
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31644166
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31224400
74E2F7_22180533_ChIP-Seq_HELA_Human1.30651845
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29710175
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29303152
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28815924
78AR_21572438_ChIP-Seq_LNCaP_Human1.28807533
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27711092
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.24332378
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24192319
82* RNF2_27304074_Chip-Seq_NSC_Mouse1.23540852
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23074073
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22923319
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22908114
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.22473697
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21121769
88* ERG_21242973_ChIP-ChIP_JURKAT_Human1.20051981
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.19970394
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19900558
91REST_21632747_ChIP-Seq_MESCs_Mouse1.19864904
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19617337
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18166036
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17305382
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17214916
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15987899
97* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15836856
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14226840
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12787529
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12010656
101SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10791322
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.08911083
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08173094
104TP53_18474530_ChIP-ChIP_U2OS_Human1.06851442
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06567947
106TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06547846
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05218271
108AR_25329375_ChIP-Seq_VCAP_Human1.05059554
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04936517
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03546886
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02339091
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02284196
113MYC_18940864_ChIP-ChIP_HL60_Human1.02036768
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01886599
115SMAD4_21799915_ChIP-Seq_A2780_Human1.01862081
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01858807
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00376521
118CLOCK_20551151_ChIP-Seq_293T_Human1.00267725
119GABP_17652178_ChIP-ChIP_JURKAT_Human1.00235096
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00146251
121TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99765340
122BCAT_22108803_ChIP-Seq_LS180_Human0.99607640
123* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99250848
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98965168
125MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97955398
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96536468
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96140959
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95629351
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95622564
130SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95289591
131MYC_18555785_ChIP-Seq_MESCs_Mouse0.94756200
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94441891
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93338353
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92639288
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.92471411
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91195226
137* SOX2_21211035_ChIP-Seq_LN229_Gbm0.89211264
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88751824
139BRD4_25478319_ChIP-Seq_HGPS_Human0.87728143
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86382321
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85949701
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85465801
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85187878
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85130768
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84962473
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84714987
147XRN2_22483619_ChIP-Seq_HELA_Human0.84070993
148EWS_26573619_Chip-Seq_HEK293_Human0.83928327
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.83492062
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83482712
151MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82987782
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82053256
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81846038
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81769554
155* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81158620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.67300525
2MP0009053_abnormal_anal_canal4.40232658
3MP0000566_synostosis3.88953110
4MP0000537_abnormal_urethra_morphology3.24880909
5MP0002249_abnormal_larynx_morphology3.08821779
6* MP0000049_abnormal_middle_ear3.06814262
7* MP0009250_abnormal_appendicular_skeleto3.06320691
8MP0005171_absent_coat_pigmentation2.94710871
9* MP0003385_abnormal_body_wall2.92031095
10* MP0003937_abnormal_limbs/digits/tail_de2.69257032
11MP0005503_abnormal_tendon_morphology2.41481404
12MP0003123_paternal_imprinting2.31881266
13MP0003942_abnormal_urinary_system2.31439120
14MP0003938_abnormal_ear_development2.25610999
15MP0002282_abnormal_trachea_morphology2.24661365
16MP0003122_maternal_imprinting2.14093176
17MP0002932_abnormal_joint_morphology2.09198759
18MP0000762_abnormal_tongue_morphology2.06826852
19* MP0003755_abnormal_palate_morphology2.05810303
20* MP0000428_abnormal_craniofacial_morphol1.98589259
21MP0002233_abnormal_nose_morphology1.87925730
22MP0000372_irregular_coat_pigmentation1.81710309
23MP0005257_abnormal_intraocular_pressure1.77855994
24* MP0003935_abnormal_craniofacial_develop1.73536119
25MP0002102_abnormal_ear_morphology1.73454888
26* MP0002116_abnormal_craniofacial_bone1.73171726
27MP0005508_abnormal_skeleton_morphology1.70075160
28MP0003011_delayed_dark_adaptation1.69678337
29MP0000534_abnormal_ureter_morphology1.67384732
30MP0009384_cardiac_valve_regurgitation1.67316953
31MP0002653_abnormal_ependyma_morphology1.64967273
32MP0003119_abnormal_digestive_system1.63768063
33MP0008438_abnormal_cutaneous_collagen1.63180088
34MP0005187_abnormal_penis_morphology1.62647435
35MP0003941_abnormal_skin_development1.62282300
36MP0002938_white_spotting1.59767832
37MP0003315_abnormal_perineum_morphology1.59122197
38MP0001485_abnormal_pinna_reflex1.53771400
39MP0003115_abnormal_respiratory_system1.53359536
40MP0006054_spinal_hemorrhage1.53007426
41* MP0000432_abnormal_head_morphology1.52506361
42MP0005248_abnormal_Harderian_gland1.52149113
43* MP0002109_abnormal_limb_morphology1.52108199
44MP0004142_abnormal_muscle_tone1.49490546
45MP0001293_anophthalmia1.48744492
46MP0002735_abnormal_chemical_nociception1.45840089
47* MP0000163_abnormal_cartilage_morphology1.45101865
48MP0001958_emphysema1.43124864
49* MP0002115_abnormal_skeleton_extremities1.41643493
50MP0005623_abnormal_meninges_morphology1.41486653
51MP0002111_abnormal_tail_morphology1.40146541
52MP0004145_abnormal_muscle_electrophysio1.40141803
53MP0004885_abnormal_endolymph1.39523360
54MP0005084_abnormal_gallbladder_morpholo1.37394555
55MP0001299_abnormal_eye_distance/1.35224713
56MP0006072_abnormal_retinal_apoptosis1.35137621
57MP0003121_genomic_imprinting1.34991683
58MP0004272_abnormal_basement_membrane1.34879572
59MP0003880_abnormal_central_pattern1.33831388
60MP0002638_abnormal_pupillary_reflex1.30681055
61MP0005499_abnormal_olfactory_system1.30662879
62MP0005394_taste/olfaction_phenotype1.30662879
63MP0002114_abnormal_axial_skeleton1.28854183
64MP0001440_abnormal_grooming_behavior1.27739220
65MP0001270_distended_abdomen1.27418134
66MP0002928_abnormal_bile_duct1.22150301
67* MP0002177_abnormal_outer_ear1.21829077
68MP0008789_abnormal_olfactory_epithelium1.20820924
69MP0005646_abnormal_pituitary_gland1.20183383
70MP0003136_yellow_coat_color1.19232513
71MP0008932_abnormal_embryonic_tissue1.19035630
72MP0002095_abnormal_skin_pigmentation1.18969649
73MP0001486_abnormal_startle_reflex1.18074465
74MP0004133_heterotaxia1.18002977
75MP0001286_abnormal_eye_development1.17436810
76MP0008995_early_reproductive_senescence1.16674468
77MP0004742_abnormal_vestibular_system1.16252168
78* MP0000778_abnormal_nervous_system1.16091765
79MP0000733_abnormal_muscle_development1.16075385
80MP0001879_abnormal_lymphatic_vessel1.16059758
81MP0001346_abnormal_lacrimal_gland1.15362098
82MP0005551_abnormal_eye_electrophysiolog1.14487265
83MP0005423_abnormal_somatic_nervous1.14399090
84MP0004134_abnormal_chest_morphology1.13459466
85* MP0002113_abnormal_skeleton_development1.12982651
86MP0002092_abnormal_eye_morphology1.12240619
87* MP0002085_abnormal_embryonic_tissue1.12156650
88MP0010368_abnormal_lymphatic_system1.11341326
89* MP0003861_abnormal_nervous_system1.09506419
90MP0009780_abnormal_chondrocyte_physiolo1.09481773
91MP0003567_abnormal_fetal_cardiomyocyte1.09357375
92MP0009745_abnormal_behavioral_response1.08633413
93* MP0002084_abnormal_developmental_patter1.08488550
94MP0001968_abnormal_touch/_nociception1.08447068
95MP0001340_abnormal_eyelid_morphology1.06837586
96MP0003279_aneurysm1.06269541
97MP0002163_abnormal_gland_morphology1.06060522
98MP0000767_abnormal_smooth_muscle1.05896903
99MP0002234_abnormal_pharynx_morphology1.05250721
100MP0001529_abnormal_vocalization1.04054478
101MP0005195_abnormal_posterior_eye1.03022139
102MP0003890_abnormal_embryonic-extraembry1.02729568
103MP0003705_abnormal_hypodermis_morpholog1.00805141
104MP0001963_abnormal_hearing_physiology0.99797107
105MP0002752_abnormal_somatic_nervous0.98080342
106MP0002064_seizures0.97856403
107MP0000516_abnormal_urinary_system0.97550877
108MP0005367_renal/urinary_system_phenotyp0.97550877
109MP0002089_abnormal_postnatal_growth/wei0.96351480
110MP0002736_abnormal_nociception_after0.95384358
111MP0000467_abnormal_esophagus_morphology0.95357689
112MP0005275_abnormal_skin_tensile0.92999100
113MP0008961_abnormal_basal_metabolism0.92964274
114MP0002098_abnormal_vibrissa_morphology0.91710404
115MP0000613_abnormal_salivary_gland0.91488717
116MP0005391_vision/eye_phenotype0.91355462
117MP0005253_abnormal_eye_physiology0.91173714
118MP0002896_abnormal_bone_mineralization0.90864693
119MP0002734_abnormal_mechanical_nocicepti0.90730702
120MP0000462_abnormal_digestive_system0.89093654
121MP0002272_abnormal_nervous_system0.88106261
122MP0001324_abnormal_eye_pigmentation0.85739859
123MP0003283_abnormal_digestive_organ0.85499772
124MP0002572_abnormal_emotion/affect_behav0.84803954
125MP0000579_abnormal_nail_morphology0.84374951
126MP0000955_abnormal_spinal_cord0.83518654
127MP0000647_abnormal_sebaceous_gland0.83470722
128MP0002697_abnormal_eye_size0.82961836
129MP0001849_ear_inflammation0.80768055
130MP0009379_abnormal_foot_pigmentation0.80054869
131* MP0002081_perinatal_lethality0.79682400
132MP0002108_abnormal_muscle_morphology0.79602566
133* MP0000631_abnormal_neuroendocrine_gland0.79593490
134MP0002160_abnormal_reproductive_system0.79386553
135MP0002557_abnormal_social/conspecific_i0.78640124
136MP0002925_abnormal_cardiovascular_devel0.78445592
137MP0004019_abnormal_vitamin_homeostasis0.77708145
138MP0002184_abnormal_innervation0.77320301
139MP0001672_abnormal_embryogenesis/_devel0.76136183
140MP0005380_embryogenesis_phenotype0.76136183
141MP0002751_abnormal_autonomic_nervous0.75039883
142MP0009703_decreased_birth_body0.74130027
143MP0006292_abnormal_olfactory_placode0.73767819
144MP0004197_abnormal_fetal_growth/weight/0.73086538
145MP0000026_abnormal_inner_ear0.72899620
146MP0000383_abnormal_hair_follicle0.71022756
147MP0010386_abnormal_urinary_bladder0.70210547
148MP0005197_abnormal_uvea_morphology0.69641700
149MP0003879_abnormal_hair_cell0.69069401
150MP0002876_abnormal_thyroid_physiology0.68790668

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.63626151
2Short 4th metacarpal (HP:0010044)3.85672161
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.85672161
4Abnormality of the middle phalanges of the toes (HP:0010183)3.80276452
5Short middle phalanx of the 5th finger (HP:0004220)3.78217216
6Abnormality of the 4th metacarpal (HP:0010012)3.74156637
7Coronal craniosynostosis (HP:0004440)3.53919815
8Neonatal short-limb short stature (HP:0008921)3.46044977
9Abnormal number of erythroid precursors (HP:0012131)3.42622068
10Abnormality of cells of the erythroid lineage (HP:0012130)3.41582921
11Broad toe (HP:0001837)3.37401544
12Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.36902287
13Shallow orbits (HP:0000586)3.28464478
14Partial duplication of the phalanx of hand (HP:0009999)3.26528465
15Split foot (HP:0001839)3.25760397
16Oligodactyly (hands) (HP:0001180)3.25489152
17Abnormality of the phalanges of the hallux (HP:0010057)3.17389900
18Focal motor seizures (HP:0011153)3.12847690
19Abnormality of the phalanges of the 5th finger (HP:0004213)3.12751542
20Reticulocytopenia (HP:0001896)3.10999791
21Stenosis of the external auditory canal (HP:0000402)3.10175271
22Renal duplication (HP:0000075)3.06883856
23Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.03082263
24* Concave nail (HP:0001598)2.99685975
25Abnormality of the parietal bone (HP:0002696)2.97493595
26Broad hallux (HP:0010055)2.96693040
27Protrusio acetabuli (HP:0003179)2.94973632
28True hermaphroditism (HP:0010459)2.94541267
29Bilateral microphthalmos (HP:0007633)2.93755932
30Premature rupture of membranes (HP:0001788)2.93211074
31Aplasia involving bones of the extremities (HP:0009825)2.84230328
32Aplasia involving bones of the upper limbs (HP:0009823)2.84230328
33Aplasia of the phalanges of the hand (HP:0009802)2.84230328
34Abnormality of the 2nd finger (HP:0004100)2.80925029
35Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.77724730
36Septo-optic dysplasia (HP:0100842)2.76767492
37Keratoconus (HP:0000563)2.74843092
38Increased corneal curvature (HP:0100692)2.74843092
39Pancreatic fibrosis (HP:0100732)2.74717349
40Esophageal atresia (HP:0002032)2.73124256
41Macrocytic anemia (HP:0001972)2.71829814
42Deviation of the hallux (HP:0010051)2.69885202
43Preaxial foot polydactyly (HP:0001841)2.69764727
44Microglossia (HP:0000171)2.69359238
45Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.68981912
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68560633
47Short 5th finger (HP:0009237)2.64604164
48Nephronophthisis (HP:0000090)2.63631757
49Abnormal umbilical cord blood vessels (HP:0011403)2.62162907
50Single umbilical artery (HP:0001195)2.62162907
51Abnormality of the fetal cardiovascular system (HP:0010948)2.62162907
52Mesomelia (HP:0003027)2.54408484
53Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.51437641
54Cutaneous finger syndactyly (HP:0010554)2.46774221
55Broad thumb (HP:0011304)2.45139599
56Abnormal ciliary motility (HP:0012262)2.45001983
57Hallux valgus (HP:0001822)2.44137014
58Pancreatic cysts (HP:0001737)2.43844703
59Carpal synostosis (HP:0009702)2.43788596
60Abnormality of the renal medulla (HP:0100957)2.39396560
61Synostosis involving the elbow (HP:0003938)2.38822598
62Humeroradial synostosis (HP:0003041)2.38822598
63Bronchomalacia (HP:0002780)2.38427917
64Aplasia/Hypoplasia of the clavicles (HP:0006710)2.36731075
65Short middle phalanx of finger (HP:0005819)2.35581333
66Synostosis of carpal bones (HP:0005048)2.35054944
67Aplasia cutis congenita (HP:0001057)2.33854806
68Medial flaring of the eyebrow (HP:0010747)2.31641762
69Short hallux (HP:0010109)2.30767738
70Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.29810880
71Abnormal respiratory motile cilium morphology (HP:0005938)2.29760408
72Abnormal respiratory epithelium morphology (HP:0012253)2.29760408
73Abnormality of the middle phalanges of the hand (HP:0009833)2.29676392
74Abnormal respiratory motile cilium physiology (HP:0012261)2.28179060
75Symphalangism affecting the phalanges of the hand (HP:0009773)2.27599154
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.26865521
77Short 1st metacarpal (HP:0010034)2.26865521
78Pendular nystagmus (HP:0012043)2.26796859
79Vaginal atresia (HP:0000148)2.25749068
80Molar tooth sign on MRI (HP:0002419)2.23141954
81Abnormality of midbrain morphology (HP:0002418)2.23141954
82Partial duplication of thumb phalanx (HP:0009944)2.22460749
83Synostosis involving bones of the hand (HP:0004278)2.21559274
84Abnormality of dentin (HP:0010299)2.19688031
85Abnormality of the lacrimal duct (HP:0011481)2.19396949
86Genital tract atresia (HP:0001827)2.18701815
87Cutaneous syndactyly (HP:0012725)2.18289189
88Oligodactyly (HP:0012165)2.16649801
89Short clavicles (HP:0000894)2.16294046
90Broad distal phalanx of finger (HP:0009836)2.15227074
91Hypoplasia of the ulna (HP:0003022)2.12038203
92Abnormality of the renal cortex (HP:0011035)2.09907901
93Broad phalanges of the hand (HP:0009768)2.09470700
94Fibular aplasia (HP:0002990)2.08769334
95Broad long bones (HP:0005622)2.08593858
96Wide anterior fontanel (HP:0000260)2.07921213
97Absent septum pellucidum (HP:0001331)2.07780078
98Pallor (HP:0000980)2.07620524
99Abnormality of the nasolacrimal system (HP:0000614)2.06702747
100Broad finger (HP:0001500)2.06414564
101Type II lissencephaly (HP:0007260)2.05202017
102Atresia of the external auditory canal (HP:0000413)2.03579708
103Broad phalanx (HP:0006009)2.02308760
104Aplasia/Hypoplasia of the hallux (HP:0008362)2.01908508
105Abnormality of the distal phalanges of the toes (HP:0010182)2.01744497
106Tarsal synostosis (HP:0008368)2.00138098
107Tracheomalacia (HP:0002779)1.99709046
108Abnormality of the right ventricle (HP:0001707)1.99689556
109Woolly hair (HP:0002224)1.99234317
110Abnormality of the 1st metacarpal (HP:0010009)1.98296758
111Arnold-Chiari malformation (HP:0002308)1.98212823
112Bladder diverticulum (HP:0000015)1.95606783
113Anencephaly (HP:0002323)1.94939393
114Sclerocornea (HP:0000647)1.94453001
115Increased hepatocellular lipid droplets (HP:0006565)1.93742945
116Vertebral fusion (HP:0002948)1.93196901
117Broad metatarsal (HP:0001783)1.92696110
118Maternal diabetes (HP:0009800)1.92689715
119Hypoplastic labia majora (HP:0000059)1.92308056
120Abnormality of the labia minora (HP:0012880)1.90723200
121Midline defect of the nose (HP:0004122)1.90380903
122Mitochondrial inheritance (HP:0001427)1.90210385
123Congenital stationary night blindness (HP:0007642)1.90158368
124Bifid scrotum (HP:0000048)1.89970652
125Abnormality of abdominal situs (HP:0011620)1.89158978
126Abdominal situs inversus (HP:0003363)1.89158978
127Bifid tongue (HP:0010297)1.88624329
128Natal tooth (HP:0000695)1.88503843
129Duplication of thumb phalanx (HP:0009942)1.88104913
130Abnormality of the proximal phalanges of the hand (HP:0009834)1.87737971
1312-3 toe syndactyly (HP:0004691)1.87132799
132Synostosis involving bones of the lower limbs (HP:0009138)1.87098845
133Synostosis involving bones of the feet (HP:0009140)1.87098845
134Aortic dissection (HP:0002647)1.86992243
135Aplasia/Hypoplasia of the fibula (HP:0006492)1.86269950
136Morphological abnormality of the middle ear (HP:0008609)1.84784621
137Increased number of teeth (HP:0011069)1.84775460
138Decreased central vision (HP:0007663)1.84467001
139Alacrima (HP:0000522)1.84356157
140Rhinitis (HP:0012384)1.83742114
141Short phalanx of the thumb (HP:0009660)1.83677031
142Morphological abnormality of the inner ear (HP:0011390)1.82118190
143Abnormality of the renal collecting system (HP:0004742)1.80945699
144Hypoplasia of the pons (HP:0012110)1.80911353
145Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79591661
146Abolished electroretinogram (ERG) (HP:0000550)1.79581251
147Fibular hypoplasia (HP:0003038)1.78824634
148Gastrointestinal atresia (HP:0002589)1.78407428
149Renal cortical cysts (HP:0000803)1.78197752
150Turricephaly (HP:0000262)1.77951568
151Fused cervical vertebrae (HP:0002949)1.76860891
152Anophthalmia (HP:0000528)1.76546883
153Abnormality of the upper arm (HP:0001454)1.76449027
154Abnormality of the labia majora (HP:0012881)1.75734873
155Congenital hepatic fibrosis (HP:0002612)1.75054944
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.75032898
157Abnormality of permanent molar morphology (HP:0011071)1.73723425
158Abnormality of the dental root (HP:0006486)1.73723425
159Taurodontia (HP:0000679)1.73723425
160Cystic liver disease (HP:0006706)1.73476110
161Thyroid-stimulating hormone excess (HP:0002925)1.73346692
162Acute necrotizing encephalopathy (HP:0006965)1.72684018
163Nasolacrimal duct obstruction (HP:0000579)1.72119062
164Lipid accumulation in hepatocytes (HP:0006561)1.71845373
165Abnormality of the pons (HP:0007361)1.70936331
166Abnormality of the humerus (HP:0003063)1.70837320
167Supernumerary spleens (HP:0009799)1.70833820
168Aplasia/Hypoplasia of the ulna (HP:0006495)1.70743196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.82927076
2EPHB24.58828857
3MKNK13.42535945
4MKNK23.34963306
5BUB13.25909600
6ADRBK23.12154273
7LATS13.09884083
8LATS23.01303357
9VRK22.82677935
10DDR22.74806265
11CDK82.74654187
12TAF12.48052992
13PDGFRA2.27133962
14MAP3K102.19764607
15SRPK12.10747627
16TNIK2.10152333
17PINK12.06488942
18VRK12.06161534
19GRK11.80240706
20DMPK1.71060145
21INSRR1.68406326
22TTN1.62690361
23MAP3K41.61523318
24FGFR11.56009708
25ZAK1.53236115
26EPHA41.51504398
27TRIB31.49364631
28MAPK151.48560604
29STK241.46711676
30BMPR1B1.33971538
31PAK21.30542116
32EPHA31.25182027
33TGFBR11.19450949
34PRKCG1.15557248
35SIK11.14295044
36PTK61.13724322
37PAK41.13370879
38ROCK21.12001172
39DYRK31.11200131
40FGFR21.10900227
41MELK1.08263758
42ERBB21.07316365
43WNK31.03920434
44BCKDK1.03534163
45NEK91.03401139
46NEK21.02161228
47CASK1.01479918
48PNCK1.00023973
49CDK70.98083586
50CDC70.97837681
51FER0.94475824
52ILK0.93764876
53WEE10.91588163
54ROCK10.91354225
55CDK90.89302042
56SGK20.85103766
57LRRK20.84580108
58STK30.84460604
59PTK20.83462086
60MAPKAPK50.83217934
61STK38L0.82343173
62CLK10.81175828
63MAP2K70.80429232
64MAPK130.80031393
65OXSR10.79598237
66STK390.78595164
67NME10.78542241
68TTK0.77140809
69KSR10.75121913
70PLK10.74838187
71TESK20.73261819
72PAK30.72811277
73IRAK20.71337943
74MARK10.71163354
75MAP3K80.70231269
76AKT20.69463097
77AURKA0.68007152
78BMX0.67960777
79CDK120.66093965
80SGK4940.65612893
81SGK2230.65612893
82TSSK60.65334220
83MTOR0.64706583
84MAP2K40.63533200
85MAP2K20.63438271
86FGFR30.63131428
87CDK30.62713607
88WNK40.61816052
89BRSK20.60826221
90CHUK0.59674797
91HIPK20.59541089
92CDC42BPA0.59435451
93CDK190.59325435
94NTRK20.59206087
95AURKB0.58891238
96BRD40.58795710
97KDR0.58499118
98CAMK1G0.58483291
99CDK40.58406826
100PASK0.57987176
101PLK30.57851940
102ICK0.57390416
103CDK60.57105582
104PRKCE0.56409599
105STK100.56347213
106RPS6KA40.55823472
107UHMK10.55450310
108PRKACA0.54857935
109DAPK30.53716219
110OBSCN0.52258126
111ADRBK10.50349176
112PBK0.50346313
113FRK0.50014991
114CSNK1E0.49990246
115MAPK90.49714869
116TYRO30.48856434
117GSK3A0.48780620
118NTRK30.48624116
119STK110.48350545
120CSNK1G10.48210258
121STK160.46120690
122PRKG10.46080321
123STK40.45377415
124PKN10.45204609
125MAP3K70.45147442
126CSNK2A10.44701521
127ERBB30.44603665
128CDK20.43378477
129PLK20.43338010
130NUAK10.42439238
131PTK2B0.42306329
132PAK10.41921905
133MUSK0.41911241
134AKT10.40789709
135PIK3CA0.40506844
136DYRK1A0.39843715
137CSNK1A1L0.39372895
138CAMK10.38662613
139AKT30.38594186
140SRC0.37780008
141CSNK1A10.37753787
142PRKD20.37545113
143PLK40.37511848
144DYRK1B0.37149437
145RPS6KA50.36965464
146RPS6KA60.36919007
147CHEK20.36789293
148DYRK20.36543833
149CDK140.36065689
150BRSK10.35986304
151PDGFRB0.35631329
152LMTK20.34639028
153CDK10.34045570
154CAMK2B0.32967762
155TIE10.32059289
156PRKD10.31918422
157PRKDC0.31679733
158PRKD30.30558630

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052175.55954618
2Hedgehog signaling pathway_Homo sapiens_hsa043404.43005039
3Oxidative phosphorylation_Homo sapiens_hsa001904.19499972
4Parkinsons disease_Homo sapiens_hsa050123.55399035
5Hippo signaling pathway_Homo sapiens_hsa043903.47231208
6Ribosome_Homo sapiens_hsa030103.20680860
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.89686274
8Wnt signaling pathway_Homo sapiens_hsa043102.81700534
9TGF-beta signaling pathway_Homo sapiens_hsa043502.74987768
10Alzheimers disease_Homo sapiens_hsa050102.71949988
11Spliceosome_Homo sapiens_hsa030402.55290168
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.46917724
13Melanogenesis_Homo sapiens_hsa049162.45627836
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39411546
15Nicotine addiction_Homo sapiens_hsa050332.24524461
16Notch signaling pathway_Homo sapiens_hsa043302.18645169
17Proteoglycans in cancer_Homo sapiens_hsa052052.03604667
18Axon guidance_Homo sapiens_hsa043602.00310391
19Cell cycle_Homo sapiens_hsa041101.98521837
20MicroRNAs in cancer_Homo sapiens_hsa052061.83240707
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77792983
22Adherens junction_Homo sapiens_hsa045201.77298674
23Protein export_Homo sapiens_hsa030601.76914257
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76569816
25Cocaine addiction_Homo sapiens_hsa050301.59211406
26Pathways in cancer_Homo sapiens_hsa052001.58564757
27Bladder cancer_Homo sapiens_hsa052191.52765437
28ECM-receptor interaction_Homo sapiens_hsa045121.49532793
29DNA replication_Homo sapiens_hsa030301.45724683
30Morphine addiction_Homo sapiens_hsa050321.45468636
31Melanoma_Homo sapiens_hsa052181.44985435
32Selenocompound metabolism_Homo sapiens_hsa004501.44753720
33* HTLV-I infection_Homo sapiens_hsa051661.43799983
34Circadian entrainment_Homo sapiens_hsa047131.43464443
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43105075
36Phototransduction_Homo sapiens_hsa047441.40601926
37Focal adhesion_Homo sapiens_hsa045101.38512586
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36857823
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32074751
40Tight junction_Homo sapiens_hsa045301.31923978
41Glutamatergic synapse_Homo sapiens_hsa047241.30512500
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25817061
43mRNA surveillance pathway_Homo sapiens_hsa030151.24312105
44Homologous recombination_Homo sapiens_hsa034401.21774993
45Vitamin digestion and absorption_Homo sapiens_hsa049771.19869440
46Rap1 signaling pathway_Homo sapiens_hsa040151.18425784
47RNA polymerase_Homo sapiens_hsa030201.14938583
48RNA transport_Homo sapiens_hsa030131.14532047
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11084372
50Prostate cancer_Homo sapiens_hsa052151.10618156
51Nucleotide excision repair_Homo sapiens_hsa034201.09995464
52Oocyte meiosis_Homo sapiens_hsa041141.09387003
53Base excision repair_Homo sapiens_hsa034101.09333992
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07198346
55GABAergic synapse_Homo sapiens_hsa047271.04567398
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03540151
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03201687
58Dilated cardiomyopathy_Homo sapiens_hsa054141.00899018
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.00026227
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99881048
61Insulin secretion_Homo sapiens_hsa049110.99319388
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97872156
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97075926
64Gap junction_Homo sapiens_hsa045400.95970294
65Dorso-ventral axis formation_Homo sapiens_hsa043200.95560439
66Taste transduction_Homo sapiens_hsa047420.95556388
67Systemic lupus erythematosus_Homo sapiens_hsa053220.95530405
68Mismatch repair_Homo sapiens_hsa034300.95496817
69Chronic myeloid leukemia_Homo sapiens_hsa052200.94526997
70Serotonergic synapse_Homo sapiens_hsa047260.94516897
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93364721
72Olfactory transduction_Homo sapiens_hsa047400.91900043
73Renal cell carcinoma_Homo sapiens_hsa052110.90614408
74Cholinergic synapse_Homo sapiens_hsa047250.89367989
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89183152
76Colorectal cancer_Homo sapiens_hsa052100.88995371
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88549928
78Amphetamine addiction_Homo sapiens_hsa050310.86490768
79Chemical carcinogenesis_Homo sapiens_hsa052040.86424771
80Protein digestion and absorption_Homo sapiens_hsa049740.85332456
81Small cell lung cancer_Homo sapiens_hsa052220.84030848
82Folate biosynthesis_Homo sapiens_hsa007900.83337569
83Fanconi anemia pathway_Homo sapiens_hsa034600.82131017
84Linoleic acid metabolism_Homo sapiens_hsa005910.81923299
85Calcium signaling pathway_Homo sapiens_hsa040200.80841298
86Thyroid cancer_Homo sapiens_hsa052160.80379928
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.78458411
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78215761
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77943101
90Huntingtons disease_Homo sapiens_hsa050160.71273038
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71198094
92Gastric acid secretion_Homo sapiens_hsa049710.68039856
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67812054
94Dopaminergic synapse_Homo sapiens_hsa047280.66957920
95Tryptophan metabolism_Homo sapiens_hsa003800.64824521
96Ras signaling pathway_Homo sapiens_hsa040140.64719070
97Estrogen signaling pathway_Homo sapiens_hsa049150.64488809
98p53 signaling pathway_Homo sapiens_hsa041150.64406613
99Glioma_Homo sapiens_hsa052140.64284455
100Alcoholism_Homo sapiens_hsa050340.63583255
101Basal transcription factors_Homo sapiens_hsa030220.63115276
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62948776
103RNA degradation_Homo sapiens_hsa030180.61675563
104Salivary secretion_Homo sapiens_hsa049700.61398065
105One carbon pool by folate_Homo sapiens_hsa006700.60289995
106Pyrimidine metabolism_Homo sapiens_hsa002400.60017033
107Renin secretion_Homo sapiens_hsa049240.59019455
108ABC transporters_Homo sapiens_hsa020100.58208120
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57550581
110Viral myocarditis_Homo sapiens_hsa054160.57008022
111Retinol metabolism_Homo sapiens_hsa008300.56938306
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56026435
113Endometrial cancer_Homo sapiens_hsa052130.54162262
114Sulfur relay system_Homo sapiens_hsa041220.53479370
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51711614
116Caffeine metabolism_Homo sapiens_hsa002320.50175509
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45482175
118Nitrogen metabolism_Homo sapiens_hsa009100.45152264
119Ovarian steroidogenesis_Homo sapiens_hsa049130.44229243
120Viral carcinogenesis_Homo sapiens_hsa052030.43868820
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43862212
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40873395
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.40780925
124Long-term depression_Homo sapiens_hsa047300.40430985
125Lysine degradation_Homo sapiens_hsa003100.39629641
126Butanoate metabolism_Homo sapiens_hsa006500.39146815
127GnRH signaling pathway_Homo sapiens_hsa049120.38981862
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38919174
129Purine metabolism_Homo sapiens_hsa002300.37898561
130MAPK signaling pathway_Homo sapiens_hsa040100.37776359
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36010213
132Cardiac muscle contraction_Homo sapiens_hsa042600.35926780
133Collecting duct acid secretion_Homo sapiens_hsa049660.35058919
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34606050
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34470087
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.34442341
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.34016907
138Amoebiasis_Homo sapiens_hsa051460.31181751
139Metabolic pathways_Homo sapiens_hsa011000.30802345
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.29391704
141FoxO signaling pathway_Homo sapiens_hsa040680.29023083
142Choline metabolism in cancer_Homo sapiens_hsa052310.28827469
143HIF-1 signaling pathway_Homo sapiens_hsa040660.28702846
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26730587
145Fat digestion and absorption_Homo sapiens_hsa049750.26467174
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24563981
147Hepatitis B_Homo sapiens_hsa051610.23935607
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23133139
149Oxytocin signaling pathway_Homo sapiens_hsa049210.21570863
150cAMP signaling pathway_Homo sapiens_hsa040240.21405776
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20542559
152Mineral absorption_Homo sapiens_hsa049780.20393320
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20090871
154Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19091178

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »