MSTO2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.22664679
2spliceosomal tri-snRNP complex assembly (GO:0000244)4.84344845
3nuclear pore organization (GO:0006999)4.36686028
4regulation of histone H3-K27 methylation (GO:0061085)4.30301807
5peptidyl-arginine omega-N-methylation (GO:0035247)4.24608982
6COPI coating of Golgi vesicle (GO:0048205)4.17583227
7Golgi transport vesicle coating (GO:0048200)4.17583227
8pore complex assembly (GO:0046931)4.04745508
9chromosome condensation (GO:0030261)4.01810257
10snRNA metabolic process (GO:0016073)3.82846625
11intracellular estrogen receptor signaling pathway (GO:0030520)3.81791675
12peptidyl-arginine methylation (GO:0018216)3.79711182
13peptidyl-arginine N-methylation (GO:0035246)3.79711182
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.77592856
15snRNA processing (GO:0016180)3.76799202
16negative regulation of erythrocyte differentiation (GO:0045647)3.76767474
17dosage compensation (GO:0007549)3.76104086
18DNA packaging (GO:0006323)3.73303385
19mitotic nuclear envelope disassembly (GO:0007077)3.54938156
20DNA unwinding involved in DNA replication (GO:0006268)3.52234158
21histone H4 deacetylation (GO:0070933)3.50148300
22glucocorticoid receptor signaling pathway (GO:0042921)3.46742704
23nuclear envelope disassembly (GO:0051081)3.41230407
24membrane disassembly (GO:0030397)3.41230407
25protein-DNA complex disassembly (GO:0032986)3.35225218
26nucleosome disassembly (GO:0006337)3.35225218
27regulation of translational fidelity (GO:0006450)3.24125208
28histone arginine methylation (GO:0034969)3.20163398
29protein insertion into membrane (GO:0051205)3.19945870
30corticosteroid receptor signaling pathway (GO:0031958)3.18010980
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15900337
32sexual reproduction (GO:0019953)3.14437244
33V(D)J recombination (GO:0033151)3.12419524
34ribosome biogenesis (GO:0042254)3.12161718
35poly(A)+ mRNA export from nucleus (GO:0016973)3.08701100
36DNA conformation change (GO:0071103)3.06168305
37nuclear envelope organization (GO:0006998)3.04798284
38negative regulation of histone methylation (GO:0031061)3.02215746
39spermatid nucleus differentiation (GO:0007289)3.00418859
40negative regulation of mRNA processing (GO:0050686)2.98352358
41negative regulation of necroptotic process (GO:0060546)2.97973497
42negative regulation of mRNA metabolic process (GO:1903312)2.97634785
43protein export from nucleus (GO:0006611)2.93638663
44mitotic chromosome condensation (GO:0007076)2.92226221
45histone H3 deacetylation (GO:0070932)2.89932332
46tRNA methylation (GO:0030488)2.89709952
47DNA strand elongation involved in DNA replication (GO:0006271)2.87835080
483-UTR-mediated mRNA stabilization (GO:0070935)2.87684441
49nucleus organization (GO:0006997)2.84944309
50regulation of RNA export from nucleus (GO:0046831)2.82811542
51proline biosynthetic process (GO:0006561)2.80608816
52mRNA export from nucleus (GO:0006406)2.79784932
53DNA strand elongation (GO:0022616)2.78645306
54DNA replication initiation (GO:0006270)2.77651653
55microtubule depolymerization (GO:0007019)2.77432411
56DNA topological change (GO:0006265)2.77376442
57mRNA splicing, via spliceosome (GO:0000398)2.74383879
58RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74383879
59regulation of chromatin binding (GO:0035561)2.73117852
60DNA duplex unwinding (GO:0032508)2.73012337
61mRNA transport (GO:0051028)2.72654521
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70047552
63telomere maintenance via semi-conservative replication (GO:0032201)2.68410627
64histone H3-K9 demethylation (GO:0033169)2.67967533
65positive regulation of gamma-delta T cell activation (GO:0046645)2.67948420
66RNA export from nucleus (GO:0006405)2.67764102
67regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67717494
68histone H3-K9 modification (GO:0061647)2.66440838
69NIK/NF-kappaB signaling (GO:0038061)2.64199001
70regulation of NFAT protein import into nucleus (GO:0051532)2.63724983
71mitotic sister chromatid segregation (GO:0000070)2.62814255
72RNA splicing, via transesterification reactions (GO:0000375)2.62174691
73mitochondrion distribution (GO:0048311)2.61427155
74histone deacetylation (GO:0016575)2.59739126
75positive regulation of granulocyte differentiation (GO:0030854)2.58602675
76DNA geometric change (GO:0032392)2.58078246
77negative thymic T cell selection (GO:0045060)2.54733516
78ribosome assembly (GO:0042255)2.52718382
79RNA methylation (GO:0001510)2.50442540
80thymic T cell selection (GO:0045061)2.49530411
81T cell lineage commitment (GO:0002360)2.48948362
82mRNA polyadenylation (GO:0006378)2.48370099
83histone H3-K4 methylation (GO:0051568)2.47898137
84negative regulation of cell size (GO:0045792)2.47643189
85nuclear export (GO:0051168)2.47136394
86negative regulation of RNA splicing (GO:0033119)2.46150642
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45938917
88establishment of viral latency (GO:0019043)2.44855276
89cellular response to interleukin-4 (GO:0071353)2.43224621
90positive regulation of DNA-templated transcription, elongation (GO:0032786)2.42903504
91regulation of nucleobase-containing compound transport (GO:0032239)2.42281587
92negative T cell selection (GO:0043383)2.41415585
93histone H3 acetylation (GO:0043966)2.40646519
94regulation of DNA damage checkpoint (GO:2000001)2.39416584
95maturation of 5.8S rRNA (GO:0000460)2.39364551
96sister chromatid segregation (GO:0000819)2.38995566
97mitotic G1 DNA damage checkpoint (GO:0031571)2.38659661
98RNA transport (GO:0050658)2.38659299
99establishment of RNA localization (GO:0051236)2.38659299
100nucleic acid transport (GO:0050657)2.38659299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54875107
2MYC_22102868_ChIP-Seq_BL_Human3.23582001
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05565295
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.05535827
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.02193915
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95037612
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.61221361
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50390814
9CIITA_25753668_ChIP-Seq_RAJI_Human2.45719400
10VDR_21846776_ChIP-Seq_THP-1_Human2.37779651
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.19426977
12* XRN2_22483619_ChIP-Seq_HELA_Human2.11522620
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10885115
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07797021
15CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.03365578
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.01662012
17CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.01339664
18POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98109754
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97063993
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91743257
21DCP1A_22483619_ChIP-Seq_HELA_Human1.87157910
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84745045
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83862633
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83778035
25KDM5A_27292631_Chip-Seq_BREAST_Human1.80425849
26GABP_19822575_ChIP-Seq_HepG2_Human1.80255540
27* MAF_26560356_Chip-Seq_TH2_Human1.73161948
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72001631
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70722046
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70591575
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70019387
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69479816
33* MAF_26560356_Chip-Seq_TH1_Human1.68040356
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67958398
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67558686
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66836515
37UTX_26944678_Chip-Seq_JUKART_Human1.66389020
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66166564
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60529556
40CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.60323994
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59933311
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.59220716
43TTF2_22483619_ChIP-Seq_HELA_Human1.52751667
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52742453
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51751629
46LXR_22292898_ChIP-Seq_THP-1_Human1.51593018
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49469567
48FOXP3_21729870_ChIP-Seq_TREG_Human1.49047637
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.48600030
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48209659
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.47287658
52TFEB_21752829_ChIP-Seq_HELA_Human1.45981573
53KDM2B_26808549_Chip-Seq_DND41_Human1.45601670
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.42937300
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42802864
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.41156013
57TCF7_22412390_ChIP-Seq_EML_Mouse1.40674331
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40596945
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40256845
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36463472
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35439844
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33356178
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31610063
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29975784
65P68_20966046_ChIP-Seq_HELA_Human1.29710000
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29466670
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29366658
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.29346243
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29299809
70VDR_23849224_ChIP-Seq_CD4+_Human1.28104170
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26859510
72MYB_26560356_Chip-Seq_TH1_Human1.25667297
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22597554
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.21528492
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20914787
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20394086
77SPI1_23547873_ChIP-Seq_NB4_Human1.19579548
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18824934
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18179324
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17307400
81VDR_24763502_ChIP-Seq_THP-1_Human1.16726420
82NCOR1_26117541_ChIP-Seq_K562_Human1.16325544
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14854104
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11870012
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11183469
86GATA1_22025678_ChIP-Seq_K562_Human1.10907562
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10672631
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07296940
89MYB_26560356_Chip-Seq_TH2_Human1.06716714
90RACK7_27058665_Chip-Seq_MCF-7_Human1.05073433
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04972233
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.03711884
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01805062
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.00816789
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.00739172
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00514287
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96193115
98PHF8_20622854_ChIP-Seq_HELA_Human0.95822758
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95593298
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95516696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.57560291
2MP0010094_abnormal_chromosome_stability3.53294646
3MP0002396_abnormal_hematopoietic_system3.14547448
4MP0005451_abnormal_body_composition2.89617001
5MP0003693_abnormal_embryo_hatching2.89271222
6MP0003077_abnormal_cell_cycle2.88926386
7MP0008260_abnormal_autophagy2.67392140
8MP0003763_abnormal_thymus_physiology2.63028793
9MP0008057_abnormal_DNA_replication2.41629384
10MP0003436_decreased_susceptibility_to2.30807222
11MP0004957_abnormal_blastocyst_morpholog2.29409325
12MP0008007_abnormal_cellular_replicative2.26266496
13MP0008058_abnormal_DNA_repair2.24937438
14MP0003172_abnormal_lysosome_physiology2.09064225
15MP0004808_abnormal_hematopoietic_stem1.93299363
16MP0000350_abnormal_cell_proliferation1.88632778
17MP0009278_abnormal_bone_marrow1.81734479
18MP0000703_abnormal_thymus_morphology1.77707044
19MP0008932_abnormal_embryonic_tissue1.77701939
20MP0005410_abnormal_fertilization1.77157901
21MP0001730_embryonic_growth_arrest1.76967573
22MP0002398_abnormal_bone_marrow1.74059435
23MP0000313_abnormal_cell_death1.64910855
24MP0003300_gastrointestinal_ulcer1.64829230
25MP0004233_abnormal_muscle_weight1.62340413
26MP0005076_abnormal_cell_differentiation1.59627434
27MP0003221_abnormal_cardiomyocyte_apopto1.56971691
28MP0009333_abnormal_splenocyte_physiolog1.54556741
29MP0003303_peritoneal_inflammation1.52074538
30MP0005621_abnormal_cell_physiology1.49666582
31MP0001835_abnormal_antigen_presentation1.49107469
32MP0002722_abnormal_immune_system1.45145164
33MP0002019_abnormal_tumor_incidence1.45073625
34MP0003786_premature_aging1.44615171
35MP0005310_abnormal_salivary_gland1.44065271
36MP0001853_heart_inflammation1.42952990
37MP0010307_abnormal_tumor_latency1.42931657
38MP0005058_abnormal_lysosome_morphology1.40598487
39MP0002080_prenatal_lethality1.39995151
40MP0002877_abnormal_melanocyte_morpholog1.39126397
41MP0001800_abnormal_humoral_immune1.36491008
42MP0001849_ear_inflammation1.35424076
43MP0000858_altered_metastatic_potential1.31684809
44MP0000490_abnormal_crypts_of1.29953258
45MP0001545_abnormal_hematopoietic_system1.29880601
46MP0005397_hematopoietic_system_phenotyp1.29880601
47MP0002429_abnormal_blood_cell1.29710801
48MP0004381_abnormal_hair_follicle1.28977766
49MP0005380_embryogenesis_phenotype1.28806579
50MP0001672_abnormal_embryogenesis/_devel1.28806579
51MP0000716_abnormal_immune_system1.25635159
52MP0004264_abnormal_extraembryonic_tissu1.25268277
53MP0005000_abnormal_immune_tolerance1.25111145
54MP0002723_abnormal_immune_serum1.24874306
55MP0004947_skin_inflammation1.24702467
56MP0002132_abnormal_respiratory_system1.24243171
57MP0008995_early_reproductive_senescence1.23176513
58MP0000689_abnormal_spleen_morphology1.22808922
59MP0002420_abnormal_adaptive_immunity1.22372756
60MP0001819_abnormal_immune_cell1.21682398
61MP0002089_abnormal_postnatal_growth/wei1.20459852
62MP0005384_cellular_phenotype1.19015142
63MP0002452_abnormal_antigen_presenting1.15468668
64MP0005623_abnormal_meninges_morphology1.15052449
65MP0006035_abnormal_mitochondrial_morpho1.14898648
66MP0003115_abnormal_respiratory_system1.14479469
67MP0003984_embryonic_growth_retardation1.14349061
68MP0003705_abnormal_hypodermis_morpholog1.12362962
69MP0003091_abnormal_cell_migration1.12059481
70MP0009672_abnormal_birth_weight1.11718405
71MP0005671_abnormal_response_to1.07165025
72MP0002088_abnormal_embryonic_growth/wei1.06387023
73MP0001929_abnormal_gametogenesis1.04588464
74MP0001348_abnormal_lacrimal_gland1.04387122
75MP0001697_abnormal_embryo_size1.01287322
76MP0000358_abnormal_cell_content/1.00952193
77MP0003453_abnormal_keratinocyte_physiol1.00588582
78MP0002166_altered_tumor_susceptibility0.96833318
79MP0003698_abnormal_male_reproductive0.96528256
80MP0002405_respiratory_system_inflammati0.96423092
81MP0001873_stomach_inflammation0.96219757
82MP0003656_abnormal_erythrocyte_physiolo0.95024672
83MP0000733_abnormal_muscle_development0.94378720
84MP0004197_abnormal_fetal_growth/weight/0.93616560
85MP0002009_preneoplasia0.90156205
86MP0002419_abnormal_innate_immunity0.89242115
87MP0005025_abnormal_response_to0.89165416
88MP0004185_abnormal_adipocyte_glucose0.86989226
89MP0002086_abnormal_extraembryonic_tissu0.85643498
90MP0001915_intracranial_hemorrhage0.82923808
91MP0005075_abnormal_melanosome_morpholog0.80655049
92MP0005387_immune_system_phenotype0.79365349
93MP0001790_abnormal_immune_system0.79365349
94MP0003950_abnormal_plasma_membrane0.76674534
95MP0000751_myopathy0.76221784
96MP0002085_abnormal_embryonic_tissue0.76133542
97MP0003566_abnormal_cell_adhesion0.75568204
98MP0000678_abnormal_parathyroid_gland0.72545403
99MP0009931_abnormal_skin_appearance0.70588595
100MP0005464_abnormal_platelet_physiology0.70400935

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.01667720
2Panhypogammaglobulinemia (HP:0003139)3.84213423
3Hypertensive crisis (HP:0100735)3.43697939
4Hypoplasia of the thymus (HP:0000778)3.28044349
5Seborrheic dermatitis (HP:0001051)3.18716781
6Pelvic girdle muscle weakness (HP:0003749)3.13545386
7Hyperacusis (HP:0010780)3.05379379
8Recurrent viral infections (HP:0004429)3.04235376
9Severe combined immunodeficiency (HP:0004430)2.90937538
10Colitis (HP:0002583)2.87057988
11Aplasia/Hypoplasia of the thymus (HP:0010515)2.85070385
12Shoulder girdle muscle weakness (HP:0003547)2.83975081
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.83663207
14Ragged-red muscle fibers (HP:0003200)2.81497341
15Combined immunodeficiency (HP:0005387)2.79962249
16Heterotopia (HP:0002282)2.75734804
17Reticulocytosis (HP:0001923)2.74912435
18Fatigue (HP:0012378)2.73280436
19Broad face (HP:0000283)2.73215909
20Granulocytopenia (HP:0001913)2.69505435
21Abnormal gallbladder physiology (HP:0012438)2.67892999
22Cholecystitis (HP:0001082)2.67892999
23Poikiloderma (HP:0001029)2.63407470
24Cerebellar dysplasia (HP:0007033)2.61628249
25Slow saccadic eye movements (HP:0000514)2.60608386
26Self-mutilation (HP:0000742)2.55732310
27Abnormality of the musculature of the pelvis (HP:0001469)2.50757577
28Abnormality of the hip-girdle musculature (HP:0001445)2.50757577
29Progressive external ophthalmoplegia (HP:0000590)2.48491695
30Viral hepatitis (HP:0006562)2.47752200
31Agammaglobulinemia (HP:0004432)2.44904677
32Patellar dislocation (HP:0002999)2.39839636
33B lymphocytopenia (HP:0010976)2.39733153
34Overlapping toe (HP:0001845)2.39328383
35Insomnia (HP:0100785)2.36866044
36Retinal dysplasia (HP:0007973)2.32330554
37Difficulty climbing stairs (HP:0003551)2.32050452
38Bowel incontinence (HP:0002607)2.28429568
39Abnormal large intestine physiology (HP:0012700)2.25963526
40Gastrointestinal infarctions (HP:0005244)2.25298064
41Abnormality of the thymus (HP:0000777)2.24668922
42Entropion (HP:0000621)2.23262692
43Acute hepatic failure (HP:0006554)2.22956012
44Progressive muscle weakness (HP:0003323)2.22777972
45Basal cell carcinoma (HP:0002671)2.21223023
46Increased IgE level (HP:0003212)2.13510314
47Gastrointestinal inflammation (HP:0004386)2.13335454
48Abnormality of the fingertips (HP:0001211)2.09475055
49Abnormality of T cell physiology (HP:0011840)2.08311085
50Cholelithiasis (HP:0001081)2.07384443
51Asymmetric septal hypertrophy (HP:0001670)2.06912303
52Recurrent fungal infections (HP:0002841)2.04881252
53Achilles tendon contracture (HP:0001771)2.03905853
5411 pairs of ribs (HP:0000878)1.99165008
55Cellulitis (HP:0100658)1.98024954
56Chronic obstructive pulmonary disease (HP:0006510)1.96697075
57Obstructive lung disease (HP:0006536)1.96697075
58Centrally nucleated skeletal muscle fibers (HP:0003687)1.96177535
59Spastic diplegia (HP:0001264)1.93907538
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90110604
61Abnormal protein N-linked glycosylation (HP:0012347)1.90110604
62Abnormal protein glycosylation (HP:0012346)1.90110604
63Abnormal glycosylation (HP:0012345)1.90110604
64Type II lissencephaly (HP:0007260)1.89626110
65Abnormality of reticulocytes (HP:0004312)1.88532306
66Atelectasis (HP:0100750)1.88528298
67Inflammation of the large intestine (HP:0002037)1.87420761
68Abnormal platelet volume (HP:0011876)1.87170336
69Abnormality of glycolysis (HP:0004366)1.87106880
70Limb-girdle muscle atrophy (HP:0003797)1.84017165
71Cervical subluxation (HP:0003308)1.82221571
72Eczematoid dermatitis (HP:0000976)1.81510022
73Increased nuchal translucency (HP:0010880)1.80998212
74Abnormality of T cells (HP:0002843)1.80328567
75Neuronal loss in central nervous system (HP:0002529)1.80306936
76Cortical dysplasia (HP:0002539)1.80171523
77Truncus arteriosus (HP:0001660)1.79412188
78Easy fatigability (HP:0003388)1.77475297
79Limb-girdle muscle weakness (HP:0003325)1.77067821
80Abnormal gallbladder morphology (HP:0012437)1.74484536
81Abnormal delayed hypersensitivity skin test (HP:0002963)1.72027340
82Hypoparathyroidism (HP:0000829)1.71428858
83Myelodysplasia (HP:0002863)1.70744002
84IgM deficiency (HP:0002850)1.69944209
85Upper limb muscle weakness (HP:0003484)1.68144159
86Abnormality of oral frenula (HP:0000190)1.68011563
87Type I transferrin isoform profile (HP:0003642)1.67504325
88Micronodular cirrhosis (HP:0001413)1.64926352
89Increased mean platelet volume (HP:0011877)1.64542048
90Abnormality of B cell number (HP:0010975)1.63864610
91Long eyelashes (HP:0000527)1.63371935
92Degeneration of anterior horn cells (HP:0002398)1.61022385
93Abnormality of the anterior horn cell (HP:0006802)1.61022385
94Distal lower limb amyotrophy (HP:0008944)1.60976193
95Gastrointestinal stroma tumor (HP:0100723)1.60543190
96Selective tooth agenesis (HP:0001592)1.60222301
97Abnormality of the Achilles tendon (HP:0005109)1.58977945
98Squamous cell carcinoma (HP:0002860)1.58713958
99Long palpebral fissure (HP:0000637)1.58602332
100Impulsivity (HP:0100710)1.57788047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.71643644
2MAP3K103.08702045
3CDK122.87527893
4TRIB32.75266717
5SRPK12.67534571
6SMG12.62072597
7SIK32.61477794
8SIK22.48256278
9MAP4K12.38386428
10TESK12.13765085
11SCYL22.08436482
12SIK12.01524946
13ERN11.92707487
14IRAK31.88612395
15PLK41.88233022
16MAPK151.82876636
17NME21.82437406
18TAOK21.81200222
19BRD41.72751011
20CDC71.70158890
21TESK21.69486980
22PIM21.56703892
23MAP3K141.53379384
24CDK41.48638810
25ICK1.47327101
26RIPK41.41947976
27MAP2K31.41820326
28CDK71.40424369
29IRAK41.38828442
30EEF2K1.35051269
31FGFR41.31319106
32CAMKK21.21025497
33CCNB11.19868473
34IRAK21.16983126
35PASK1.09917564
36BUB11.07933455
37JAK31.07555471
38TBK11.00909890
39EIF2AK11.00526743
40TSSK60.89467656
41CDK60.89025300
42VRK20.87355669
43PAK40.85543107
44ATR0.85483563
45KSR20.85160951
46MAP3K70.84589335
47STK380.83227444
48TTK0.82231412
49NME10.80172203
50DYRK1B0.78542003
51CHEK10.77249293
52MST1R0.76549020
53MAPK110.76309881
54MAP3K110.73881526
55MTOR0.72516027
56RAF10.71061810
57MAP3K80.69678126
58ZAP700.68382500
59PDGFRA0.67978964
60CDK20.66674744
61KDR0.65621767
62MARK20.65101224
63BMX0.64254377
64CHEK20.62986485
65CAMKK10.60923721
66TYRO30.60605400
67IKBKE0.60344696
68GRK60.59948904
69MAP3K130.59310125
70IRAK10.59236557
71DDR20.59099117
72MAP3K30.57816623
73STK100.57600348
74CLK10.57166086
75AURKA0.56423555
76PRKD30.55722561
77MARK30.55484366
78CDK30.55363474
79CDK80.55270029
80MAP3K60.49359143
81MAP3K10.49104892
82RPS6KA40.48329384
83TYK20.47908667
84CDK90.45782855
85MATK0.41008058
86HCK0.40206148
87CDK10.40038469
88TAOK30.38839665
89PRKD20.37175732
90BTK0.37074778
91EPHB10.37062619
92LCK0.36714381
93AURKB0.34647457
94CDC42BPA0.34384449
95BCKDK0.32829391
96MAP3K50.32424403
97EPHA30.31779519
98TAOK10.31371545
99BRSK10.31181080
100FGR0.31047851

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.14426849
2Spliceosome_Homo sapiens_hsa030402.70283988
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63395508
4Base excision repair_Homo sapiens_hsa034102.21227477
5Primary immunodeficiency_Homo sapiens_hsa053402.06870095
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97212309
7Acute myeloid leukemia_Homo sapiens_hsa052211.93582913
8mRNA surveillance pathway_Homo sapiens_hsa030151.91583494
9RNA transport_Homo sapiens_hsa030131.88894153
10Mismatch repair_Homo sapiens_hsa034301.71327535
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69127922
12Cell cycle_Homo sapiens_hsa041101.68925469
13Chronic myeloid leukemia_Homo sapiens_hsa052201.67449940
14Epstein-Barr virus infection_Homo sapiens_hsa051691.64748265
15Non-small cell lung cancer_Homo sapiens_hsa052231.63942083
16Non-homologous end-joining_Homo sapiens_hsa034501.57684706
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55226628
18Herpes simplex infection_Homo sapiens_hsa051681.53680533
19Nucleotide excision repair_Homo sapiens_hsa034201.52101040
20Hepatitis B_Homo sapiens_hsa051611.51033965
21Other glycan degradation_Homo sapiens_hsa005111.50416679
22B cell receptor signaling pathway_Homo sapiens_hsa046621.45130236
23RNA polymerase_Homo sapiens_hsa030201.38112786
24Pancreatic cancer_Homo sapiens_hsa052121.37726424
25Biosynthesis of amino acids_Homo sapiens_hsa012301.34473269
26Viral carcinogenesis_Homo sapiens_hsa052031.30889133
27Measles_Homo sapiens_hsa051621.30351442
28Sulfur relay system_Homo sapiens_hsa041221.28642895
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24851789
30Pyrimidine metabolism_Homo sapiens_hsa002401.23708990
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21679151
32Thyroid cancer_Homo sapiens_hsa052161.19679066
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.19095187
34Notch signaling pathway_Homo sapiens_hsa043301.18202252
35Influenza A_Homo sapiens_hsa051641.17887927
36Fructose and mannose metabolism_Homo sapiens_hsa000511.15205428
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13676836
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13035830
39Shigellosis_Homo sapiens_hsa051311.11348147
40Homologous recombination_Homo sapiens_hsa034401.10220820
41T cell receptor signaling pathway_Homo sapiens_hsa046601.09854224
42Pentose phosphate pathway_Homo sapiens_hsa000301.07083914
43N-Glycan biosynthesis_Homo sapiens_hsa005101.04847192
44Colorectal cancer_Homo sapiens_hsa052101.04472163
45Lysine degradation_Homo sapiens_hsa003101.03510737
46Bladder cancer_Homo sapiens_hsa052191.02399139
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.99802142
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.99771808
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99688065
50HTLV-I infection_Homo sapiens_hsa051660.98870050
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98119408
52mTOR signaling pathway_Homo sapiens_hsa041500.95544092
53Endometrial cancer_Homo sapiens_hsa052130.95013373
54Fanconi anemia pathway_Homo sapiens_hsa034600.92336523
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.90954705
56Apoptosis_Homo sapiens_hsa042100.90216663
57Prostate cancer_Homo sapiens_hsa052150.89303025
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87459994
59Small cell lung cancer_Homo sapiens_hsa052220.86641975
60Osteoclast differentiation_Homo sapiens_hsa043800.86381580
61VEGF signaling pathway_Homo sapiens_hsa043700.86284859
62Viral myocarditis_Homo sapiens_hsa054160.85638340
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84861094
64Toxoplasmosis_Homo sapiens_hsa051450.83625827
65Leishmaniasis_Homo sapiens_hsa051400.83614856
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82210950
67Renal cell carcinoma_Homo sapiens_hsa052110.81826531
68MicroRNAs in cancer_Homo sapiens_hsa052060.80349757
69Carbon metabolism_Homo sapiens_hsa012000.79712340
70Prolactin signaling pathway_Homo sapiens_hsa049170.79148215
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.76632114
72TNF signaling pathway_Homo sapiens_hsa046680.74906709
73Protein export_Homo sapiens_hsa030600.72948137
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72425333
75ErbB signaling pathway_Homo sapiens_hsa040120.71161675
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70792637
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69820584
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68792351
79Proteasome_Homo sapiens_hsa030500.67826286
80Glioma_Homo sapiens_hsa052140.66482188
81Antigen processing and presentation_Homo sapiens_hsa046120.64201913
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63183566
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62140294
84Legionellosis_Homo sapiens_hsa051340.61779557
85Hepatitis C_Homo sapiens_hsa051600.61101172
86One carbon pool by folate_Homo sapiens_hsa006700.60803391
87Inositol phosphate metabolism_Homo sapiens_hsa005620.60069426
88Endocytosis_Homo sapiens_hsa041440.58215075
89Basal transcription factors_Homo sapiens_hsa030220.57452724
90Choline metabolism in cancer_Homo sapiens_hsa052310.57422404
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55487236
92Salmonella infection_Homo sapiens_hsa051320.54192755
93RNA degradation_Homo sapiens_hsa030180.53223473
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52716078
95Selenocompound metabolism_Homo sapiens_hsa004500.49810670
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49680547
97AMPK signaling pathway_Homo sapiens_hsa041520.49552825
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.48188112
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47894314
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47729014

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