MST1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.53464517
2hemidesmosome assembly (GO:0031581)7.21092445
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.83974972
4activation of Rac GTPase activity (GO:0032863)5.30452888
5positive regulation of Cdc42 GTPase activity (GO:0043089)5.20861833
6regulation of water loss via skin (GO:0033561)4.63345893
7establishment of skin barrier (GO:0061436)4.49280623
8regulation of apoptotic cell clearance (GO:2000425)4.34160238
9Golgi transport vesicle coating (GO:0048200)4.30591915
10COPI coating of Golgi vesicle (GO:0048205)4.30591915
11intestinal absorption (GO:0050892)4.07868151
12renal filtration (GO:0097205)4.01719729
13branching involved in mammary gland duct morphogenesis (GO:0060444)3.99728968
14negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.91823126
15keratinization (GO:0031424)3.90419412
16apoptotic cell clearance (GO:0043277)3.88661007
17positive regulation of pseudopodium assembly (GO:0031274)3.85581703
18O-glycan processing (GO:0016266)3.83435438
19citrulline biosynthetic process (GO:0019240)3.80873583
20semaphorin-plexin signaling pathway (GO:0071526)3.77122902
21epithelial cell-cell adhesion (GO:0090136)3.70967438
22complement activation, alternative pathway (GO:0006957)3.70801418
23regulation of cholesterol homeostasis (GO:2000188)3.68984742
24GDP-mannose metabolic process (GO:0019673)3.65566470
25positive regulation of epidermal cell differentiation (GO:0045606)3.60226790
26NADH metabolic process (GO:0006734)3.47233466
27regulation of integrin activation (GO:0033623)3.45780203
28regulation of pseudopodium assembly (GO:0031272)3.36084102
29lipoxygenase pathway (GO:0019372)3.34768170
30citrulline metabolic process (GO:0000052)3.30950712
31maintenance of gastrointestinal epithelium (GO:0030277)3.30416258
32low-density lipoprotein particle clearance (GO:0034383)3.27086930
33multicellular organismal water homeostasis (GO:0050891)3.21088359
34keratinocyte proliferation (GO:0043616)3.21007539
35regulation of viral release from host cell (GO:1902186)3.16043820
36ventricular cardiac muscle cell action potential (GO:0086005)3.15929300
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15914943
38epithelial structure maintenance (GO:0010669)3.15796829
39protein autoprocessing (GO:0016540)3.14955145
40peptide cross-linking (GO:0018149)3.14156736
41regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.13961121
42cell-substrate junction assembly (GO:0007044)3.11560687
43mannose metabolic process (GO:0006013)3.11182896
44negative regulation of protein tyrosine kinase activity (GO:0061099)3.10406433
45white fat cell differentiation (GO:0050872)3.10317208
46phospholipid efflux (GO:0033700)3.10015556
47calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.09156091
48protein retention in ER lumen (GO:0006621)3.08995048
49keratinocyte differentiation (GO:0030216)3.08651596
50retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08010542
51proline biosynthetic process (GO:0006561)3.07716898
52regulation of guanylate cyclase activity (GO:0031282)3.05637496
53dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03629883
54leukotriene metabolic process (GO:0006691)3.02190631
55regulation of cholesterol storage (GO:0010885)3.02109255
56receptor catabolic process (GO:0032801)3.02091227
57glomerular filtration (GO:0003094)3.00992947
58urea cycle (GO:0000050)2.99502239
59bile acid and bile salt transport (GO:0015721)2.98663315
60regulation of cholesterol transport (GO:0032374)2.96259617
61regulation of sterol transport (GO:0032371)2.96259617
62regulation of keratinocyte differentiation (GO:0045616)2.96186407
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95442316
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.94503503
65mesodermal cell differentiation (GO:0048333)2.93602017
66surfactant homeostasis (GO:0043129)2.93206518
67lung epithelium development (GO:0060428)2.93143773
68tight junction assembly (GO:0070830)2.93047563
69gap junction assembly (GO:0016264)2.92369261
70regulation of phospholipase A2 activity (GO:0032429)2.89615035
71artery development (GO:0060840)2.88834444
72negative regulation of viral release from host cell (GO:1902187)2.88788230
73renal system process involved in regulation of blood volume (GO:0001977)2.87781252
74sphingoid metabolic process (GO:0046519)2.87588152
75intestinal epithelial cell development (GO:0060576)2.86267459
76intermediate filament organization (GO:0045109)2.85533400
77positive regulation of keratinocyte differentiation (GO:0045618)2.84212881
78regulation of Cdc42 GTPase activity (GO:0043088)2.83987104
79angiotensin maturation (GO:0002003)2.82275239
80positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.81611326
81brown fat cell differentiation (GO:0050873)2.81377758
82intestinal cholesterol absorption (GO:0030299)2.80274937
83cell communication involved in cardiac conduction (GO:0086065)2.79834388
84apoptotic process involved in morphogenesis (GO:0060561)2.79784887
85cytoskeletal anchoring at plasma membrane (GO:0007016)2.79150742
86vitamin transmembrane transport (GO:0035461)2.78183127
87diol metabolic process (GO:0034311)2.78087320
88endothelial cell chemotaxis (GO:0035767)2.76524058
89lipoprotein transport (GO:0042953)2.76376452
90urea metabolic process (GO:0019627)2.73254878
91establishment of apical/basal cell polarity (GO:0035089)2.72421614
92regulation of cholesterol efflux (GO:0010874)2.72139924
93positive regulation of cholesterol efflux (GO:0010875)2.72044534
94regulation of keratinocyte proliferation (GO:0010837)2.71740841
95cell-cell junction assembly (GO:0007043)2.71620467
96cGMP-mediated signaling (GO:0019934)2.69115452
97skin morphogenesis (GO:0043589)2.66426450
98cell-substrate adherens junction assembly (GO:0007045)2.66328529
99focal adhesion assembly (GO:0048041)2.66328529
100sulfate transmembrane transport (GO:1902358)2.65806553
101adhesion of symbiont to host cell (GO:0044650)2.65763192
102virion attachment to host cell (GO:0019062)2.65763192
103phosphatidylethanolamine biosynthetic process (GO:0006646)2.64734950
104positive regulation of protein localization to plasma membrane (GO:1903078)2.64311698
105regulation of macrophage chemotaxis (GO:0010758)2.64247908
106water homeostasis (GO:0030104)2.64039773
107atrioventricular valve morphogenesis (GO:0003181)2.62648982
108adherens junction assembly (GO:0034333)2.61914489
109production of molecular mediator involved in inflammatory response (GO:0002532)2.61686096
110sphingosine metabolic process (GO:0006670)2.60970315
111regulation of cardioblast differentiation (GO:0051890)2.60851456
112negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.60685610
113phospholipid scrambling (GO:0017121)2.59412723
114regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.59037856
115cyclooxygenase pathway (GO:0019371)2.58401286
116actin filament depolymerization (GO:0030042)2.58039939
117amyloid precursor protein metabolic process (GO:0042982)2.58032496
118peptide catabolic process (GO:0043171)2.57736542
119chondrocyte proliferation (GO:0035988)2.57718030
120filopodium assembly (GO:0046847)2.56946333
121positive regulation of fatty acid oxidation (GO:0046321)2.56929920
122regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.56912993
123negative regulation of keratinocyte proliferation (GO:0010839)2.55851829
124pyrimidine-containing compound transmembrane transport (GO:0072531)2.55833059
125positive regulation of sterol transport (GO:0032373)2.55492976
126positive regulation of cholesterol transport (GO:0032376)2.55492976
127morphogenesis of embryonic epithelium (GO:0016331)2.54930854
128regulation of endothelial cell chemotaxis (GO:2001026)2.54247600
129negative regulation of protein autophosphorylation (GO:0031953)2.53807951
130vitamin A metabolic process (GO:0006776)2.53619865
131cellular response to epidermal growth factor stimulus (GO:0071364)2.53448302
132phosphatidylinositol acyl-chain remodeling (GO:0036149)2.52319718
133cellular response to lithium ion (GO:0071285)2.51884778
134interleukin-1-mediated signaling pathway (GO:0070498)2.49584666
135epidermal cell differentiation (GO:0009913)2.49363674
136positive regulation of p38MAPK cascade (GO:1900745)2.49074325
137hypotonic response (GO:0006971)2.48840582
138barbed-end actin filament capping (GO:0051016)2.48582656
139regulation of T cell tolerance induction (GO:0002664)2.47631467
140extracellular matrix assembly (GO:0085029)2.47356948
141cell volume homeostasis (GO:0006884)2.47324802
142positive regulation of receptor recycling (GO:0001921)2.46744565
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46432313
144positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.45703985
145glutathione biosynthetic process (GO:0006750)2.44963944
146regulation of histone phosphorylation (GO:0033127)2.44616414
147carnitine shuttle (GO:0006853)2.44392695
1483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44225408
149purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44225408
150glutamine family amino acid biosynthetic process (GO:0009084)2.43940236
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43875857
152mammary gland epithelial cell proliferation (GO:0033598)2.43631859
153positive regulation of epidermis development (GO:0045684)2.43533439
154regulation of p38MAPK cascade (GO:1900744)2.43526324
155protein heterotrimerization (GO:0070208)2.42986272
156negative regulation of myotube differentiation (GO:0010832)2.42131557
157regulation of macrophage derived foam cell differentiation (GO:0010743)2.41982185
158arachidonic acid metabolic process (GO:0019369)2.41683465
159negative regulation of sterol transport (GO:0032372)2.41413213
160negative regulation of cholesterol transport (GO:0032375)2.41413213
161regulation of heart rate by cardiac conduction (GO:0086091)2.40352826
162renal system development (GO:0072001)2.40343000
163nucleotide-sugar biosynthetic process (GO:0009226)2.39920456
164digestive system process (GO:0022600)2.39160385
165phosphatidylethanolamine metabolic process (GO:0046337)2.38490704
166negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.37950235
167peptidyl-tyrosine autophosphorylation (GO:0038083)2.37039967
168ectoderm development (GO:0007398)2.35504685
169regulation of sequestering of triglyceride (GO:0010889)2.34813279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30342395
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.28998002
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24943693
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.61714033
5CDX2_20551321_ChIP-Seq_CACO-2_Human2.41582559
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31932337
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.09312612
8SOX2_20726797_ChIP-Seq_SW620_Human2.01838588
9TP63_17297297_ChIP-ChIP_HaCaT_Human10.4180518
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97792647
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95641325
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.95311444
13CLOCK_20551151_ChIP-Seq_293T_Human1.92322387
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91746946
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89419169
16* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.81929155
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78358345
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77213770
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.73595263
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.73227325
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63358579
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61166057
23GATA4_25053715_ChIP-Seq_YYC3_Human1.60684232
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59661299
25RACK7_27058665_Chip-Seq_MCF-7_Human1.59182929
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58830604
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58559718
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.55923248
29ZNF263_19887448_ChIP-Seq_K562_Human1.55835184
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52451785
31KLF5_25053715_ChIP-Seq_YYC3_Human1.51494985
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50418416
33SMC4_20622854_ChIP-Seq_HELA_Human1.46614358
34* GATA6_25053715_ChIP-Seq_YYC3_Human1.46053654
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45112019
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43212472
37* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43149267
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43014024
39P68_20966046_ChIP-Seq_HELA_Human1.41742233
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40938513
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40938513
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40788367
43LXR_22292898_ChIP-Seq_THP-1_Human1.39634126
44* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35257163
45AR_21909140_ChIP-Seq_LNCAP_Human1.32756123
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.31643838
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30996187
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28570793
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27927201
50VDR_21846776_ChIP-Seq_THP-1_Human1.27027653
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26778595
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.24794314
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23948782
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22078635
55TCF7_22412390_ChIP-Seq_EML_Mouse1.21942379
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.20682201
57* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20667059
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18970004
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.18511917
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18333168
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17767724
62* ATF3_27146783_Chip-Seq_COLON_Human1.17223462
63CJUN_26792858_Chip-Seq_BT549_Human1.17196048
64* BCOR_27268052_Chip-Seq_Bcells_Human1.16230462
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15865991
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15823664
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.13602409
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12324859
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12221727
70TP63_22573176_ChIP-Seq_HFKS_Human1.12072546
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11297094
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10873808
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09165889
74TP53_22127205_ChIP-Seq_IMR90_Human1.09138768
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05828465
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.05537866
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05062127
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03908667
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03536194
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03253846
81BCL6_27268052_Chip-Seq_Bcells_Human1.02234169
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01395836
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00242886
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99679695
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99539415
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99417560
87GATA1_22025678_ChIP-Seq_K562_Human0.99000896
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98147937
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97933583
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97568598
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97388696
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96899616
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.96708281
94E2F1_20622854_ChIP-Seq_HELA_Human0.95863853
95KDM2B_26808549_Chip-Seq_DND41_Human0.95639086
96ERG_21242973_ChIP-ChIP_JURKAT_Human0.95184796
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93866967
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93496818
99* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93230530
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92489526
101EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91880930
102JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91792906
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.91769877
104NCOR1_26117541_ChIP-Seq_K562_Human0.91581588
105* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90828547
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90652534
107CTCF_27219007_Chip-Seq_Bcells_Human0.90381361
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90165978
109KDM2B_26808549_Chip-Seq_K562_Human0.90014345
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89462223
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87829146
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86407933
113GATA2_19941826_ChIP-Seq_K562_Human0.86396694
114IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85065193
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84811990
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84216970
117CREB1_26743006_Chip-Seq_LNCaP_Human0.83749928
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.83433497
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83046444
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82605784
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82133039
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81501124
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81450874
124EGR1_19032775_ChIP-ChIP_M12_Human0.78567468
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76509726
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.76114258
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75803090
128* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75752083
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75214391
130DROSHA_22980978_ChIP-Seq_HELA_Human0.75078133
131AHR_22903824_ChIP-Seq_MCF-7_Human0.74770772
132BCAT_22108803_ChIP-Seq_LS180_Human0.73701191
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.72819173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.48207209
2MP0005275_abnormal_skin_tensile4.27255003
3MP0002796_impaired_skin_barrier4.18359252
4MP0005377_hearing/vestibular/ear_phenot3.70250118
5MP0003878_abnormal_ear_physiology3.70250118
6MP0002822_catalepsy3.54737206
7MP0003705_abnormal_hypodermis_morpholog3.45807641
8MP0000566_synostosis3.11541699
9MP0002060_abnormal_skin_morphology2.89807764
10MP0002254_reproductive_system_inflammat2.87666647
11MP0008438_abnormal_cutaneous_collagen2.87013644
12MP0005670_abnormal_white_adipose2.62395601
13MP0003941_abnormal_skin_development2.56043180
14MP0004185_abnormal_adipocyte_glucose2.54120980
15MP0005409_darkened_coat_color2.36537178
16MP0005501_abnormal_skin_physiology2.34770304
17MP0008004_abnormal_stomach_pH2.26181099
18MP0000678_abnormal_parathyroid_gland2.22183008
19MP0001666_abnormal_nutrient_absorption2.21658913
20MP0005257_abnormal_intraocular_pressure2.10943389
21MP0001216_abnormal_epidermal_layer2.10842698
22MP0004947_skin_inflammation2.07482912
23MP0003283_abnormal_digestive_organ2.07259279
24MP0003566_abnormal_cell_adhesion1.98074495
25MP0003191_abnormal_cellular_cholesterol1.94956073
26MP0004782_abnormal_surfactant_physiolog1.93781964
27MP0001873_stomach_inflammation1.90682668
28MP0005360_urolithiasis1.87713650
29MP0005167_abnormal_blood-brain_barrier1.76468696
30MP0010771_integument_phenotype1.76096778
31MP0000013_abnormal_adipose_tissue1.73100239
32MP0000467_abnormal_esophagus_morphology1.72509284
33MP0000579_abnormal_nail_morphology1.68286490
34MP0002877_abnormal_melanocyte_morpholog1.67012266
35MP0005451_abnormal_body_composition1.65914594
36MP0005083_abnormal_biliary_tract1.64664385
37MP0004272_abnormal_basement_membrane1.63870797
38MP0003453_abnormal_keratinocyte_physiol1.63270662
39MP0010678_abnormal_skin_adnexa1.62977840
40MP0001849_ear_inflammation1.60913760
41MP0005666_abnormal_adipose_tissue1.57716824
42MP0000462_abnormal_digestive_system1.55985190
43MP0004264_abnormal_extraembryonic_tissu1.55191079
44MP0003724_increased_susceptibility_to1.42295293
45MP0008875_abnormal_xenobiotic_pharmacok1.41651923
46MP0010352_gastrointestinal_tract_polyps1.40178583
47MP0000383_abnormal_hair_follicle1.40168970
48MP0003866_abnormal_defecation1.37089183
49MP0003300_gastrointestinal_ulcer1.33371211
50MP0000537_abnormal_urethra_morphology1.33162863
51MP0001664_abnormal_digestion1.31663450
52MP0010329_abnormal_lipoprotein_level1.30059547
53MP0002098_abnormal_vibrissa_morphology1.29382596
54MP0003806_abnormal_nucleotide_metabolis1.27843111
55MP0003183_abnormal_peptide_metabolism1.26927095
56MP0009379_abnormal_foot_pigmentation1.26465230
57MP0005058_abnormal_lysosome_morphology1.24099532
58MP0005367_renal/urinary_system_phenotyp1.23951357
59MP0000516_abnormal_urinary_system1.23951357
60MP0001663_abnormal_digestive_system1.20424159
61MP0005381_digestive/alimentary_phenotyp1.20414929
62MP0004019_abnormal_vitamin_homeostasis1.19957404
63MP0004130_abnormal_muscle_cell1.16387553
64MP0005375_adipose_tissue_phenotype1.15098904
65MP0000858_altered_metastatic_potential1.12703559
66MP0005023_abnormal_wound_healing1.12400384
67MP0000762_abnormal_tongue_morphology1.11581545
68MP0008260_abnormal_autophagy1.11298347
69MP0000377_abnormal_hair_follicle1.10850481
70MP0004858_abnormal_nervous_system1.10006333
71MP0009931_abnormal_skin_appearance1.09656541
72MP0003693_abnormal_embryo_hatching1.09612895
73MP0005365_abnormal_bile_salt1.09480234
74MP0000627_abnormal_mammary_gland1.08788126
75MP0000538_abnormal_urinary_bladder1.08742656
76MP0009384_cardiac_valve_regurgitation1.08249489
77MP0005076_abnormal_cell_differentiation1.08006314
78MP0000477_abnormal_intestine_morphology1.06940663
79MP0002139_abnormal_hepatobiliary_system1.04810227
80MP0010155_abnormal_intestine_physiology1.03170065
81MP0006054_spinal_hemorrhage1.02331502
82MP0000647_abnormal_sebaceous_gland1.00102034
83MP0009053_abnormal_anal_canal0.96310620
84MP0000003_abnormal_adipose_tissue0.96234780
85MP0001243_abnormal_dermal_layer0.95820964
86MP0002166_altered_tumor_susceptibility0.95484570
87MP0001348_abnormal_lacrimal_gland0.94891297
88MP0003315_abnormal_perineum_morphology0.94430123
89MP0009840_abnormal_foam_cell0.91076687
90MP0002909_abnormal_adrenal_gland0.91008781
91MP0001533_abnormal_skeleton_physiology0.90970553
92MP0002896_abnormal_bone_mineralization0.90168278
93MP0000427_abnormal_hair_cycle0.90074684
94MP0001191_abnormal_skin_condition0.89850370
95MP0003091_abnormal_cell_migration0.88715821
96MP0000751_myopathy0.87172758
97MP0002249_abnormal_larynx_morphology0.86346301
98MP0009780_abnormal_chondrocyte_physiolo0.86034380
99MP0003436_decreased_susceptibility_to0.81303753
100MP0004043_abnormal_pH_regulation0.80512715
101MP0004381_abnormal_hair_follicle0.78726305
102MP0002089_abnormal_postnatal_growth/wei0.78284363
103MP0003045_fibrosis0.76519106
104MP0002136_abnormal_kidney_physiology0.75736635
105MP0005503_abnormal_tendon_morphology0.74523264
106MP0001851_eye_inflammation0.74484957
107MP0004957_abnormal_blastocyst_morpholog0.73791721
108MP0001881_abnormal_mammary_gland0.73775373
109MP0000465_gastrointestinal_hemorrhage0.73410047
110MP0002971_abnormal_brown_adipose0.72061717
111MP0000490_abnormal_crypts_of0.71771937
112MP0001765_abnormal_ion_homeostasis0.71527276
113MP0002118_abnormal_lipid_homeostasis0.71079276
114MP0002006_tumorigenesis0.70800645
115MP0000470_abnormal_stomach_morphology0.70349654
116MP0009115_abnormal_fat_cell0.70056308
117MP0010030_abnormal_orbit_morphology0.69988315
118MP0005085_abnormal_gallbladder_physiolo0.69485420
119MP0001756_abnormal_urination0.66169966
120MP0005165_increased_susceptibility_to0.65629461
121MP0009643_abnormal_urine_homeostasis0.65105187
122MP0006138_congestive_heart_failure0.63921383
123MP0003075_altered_response_to0.63753833
124MP0004484_altered_response_of0.63520773
125MP0003950_abnormal_plasma_membrane0.63261054
126MP0005390_skeleton_phenotype0.63218181
127MP0003385_abnormal_body_wall0.61668453
128MP0002086_abnormal_extraembryonic_tissu0.60285740
129MP0001958_emphysema0.58782739
130MP0005166_decreased_susceptibility_to0.55070334
131MP0000367_abnormal_coat/_hair0.54962732
132MP0001730_embryonic_growth_arrest0.54379518
133MP0005621_abnormal_cell_physiology0.51264199

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.97964539
2Milia (HP:0001056)4.97887635
3Atrophic scars (HP:0001075)4.52726896
4Plantar hyperkeratosis (HP:0007556)4.18290954
5Fragile nails (HP:0001808)4.11807447
6Systemic lupus erythematosus (HP:0002725)4.11787795
7Woolly hair (HP:0002224)4.02897515
8Malnutrition (HP:0004395)3.99650217
9Onycholysis (HP:0001806)3.95306848
10Hyperactive renin-angiotensin system (HP:0000841)3.84170597
11Pustule (HP:0200039)3.59629042
12Flat acetabular roof (HP:0003180)3.46253258
13Ventricular tachycardia (HP:0004756)3.39635943
14Oligomenorrhea (HP:0000876)3.39252319
15Distal lower limb amyotrophy (HP:0008944)3.38894070
16Fragile skin (HP:0001030)3.35092286
17Broad face (HP:0000283)3.34905719
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.32628369
19Prostate neoplasm (HP:0100787)3.26097810
20Ileus (HP:0002595)3.23953226
21Pili torti (HP:0003777)3.20763101
22Palmoplantar hyperkeratosis (HP:0000972)3.15690496
23Hypotrichosis (HP:0001006)3.13005914
24Focal segmental glomerulosclerosis (HP:0000097)3.12616524
25Alopecia of scalp (HP:0002293)3.06038935
26Increased connective tissue (HP:0009025)3.03576033
27Ankyloglossia (HP:0010296)3.03242923
28Abnormality of complement system (HP:0005339)2.99237294
29Acanthosis nigricans (HP:0000956)2.98893559
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.98446485
31Increased IgE level (HP:0003212)2.93606999
32Ridged nail (HP:0001807)2.92907561
33Hemorrhage of the eye (HP:0011885)2.91205689
34Pterygium (HP:0001059)2.88682743
35Distal upper limb amyotrophy (HP:0007149)2.86940703
36Upper limb amyotrophy (HP:0009129)2.86940703
37Shallow orbits (HP:0000586)2.86000759
38Broad metatarsal (HP:0001783)2.84786110
39Palmar hyperkeratosis (HP:0010765)2.84141739
40Complement deficiency (HP:0004431)2.78469880
41Glomerulosclerosis (HP:0000096)2.77347648
42Lip pit (HP:0100267)2.65291666
43Abnormality of the distal phalanges of the toes (HP:0010182)2.64900935
44Short nail (HP:0001799)2.62107282
45Toxemia of pregnancy (HP:0100603)2.58070958
46Polygenic inheritance (HP:0010982)2.57411653
47Abnormality of nail color (HP:0100643)2.57361489
48Glomerulonephritis (HP:0000099)2.57000678
49Thick nail (HP:0001805)2.55523215
50Abnormal blistering of the skin (HP:0008066)2.55363181
51Conjunctival hamartoma (HP:0100780)2.54331698
52Neonatal short-limb short stature (HP:0008921)2.51166846
53Nail dystrophy (HP:0008404)2.51046032
54Trismus (HP:0000211)2.48150634
55Selective tooth agenesis (HP:0001592)2.44927535
56Short hallux (HP:0010109)2.43301806
57Symphalangism affecting the phalanges of the hand (HP:0009773)2.41938395
58Hyperacusis (HP:0010780)2.41711257
59Abnormality of the 1st metacarpal (HP:0010009)2.36484950
60Cerebral aneurysm (HP:0004944)2.35081290
61Sparse eyelashes (HP:0000653)2.34343887
62Axonal loss (HP:0003447)2.33554108
63Bronchomalacia (HP:0002780)2.32917640
64Cupped ribs (HP:0000887)2.30481909
65Abnormality of oral frenula (HP:0000190)2.30147721
66Vacuolated lymphocytes (HP:0001922)2.29774103
67Aortic dissection (HP:0002647)2.26758856
68Distal lower limb muscle weakness (HP:0009053)2.26453596
69Abnormality of the 2nd finger (HP:0004100)2.25649116
70Abnormality of the middle phalanges of the toes (HP:0010183)2.24668329
71Peritonitis (HP:0002586)2.24548344
72Congenital ichthyosiform erythroderma (HP:0007431)2.23688625
73Aplasia cutis congenita (HP:0001057)2.22295612
74Thin bony cortex (HP:0002753)2.22238484
75Abnormality of small intestinal villus morphology (HP:0011472)2.22207085
76Villous atrophy (HP:0011473)2.22207085
77Aplasia/Hypoplasia of the hallux (HP:0008362)2.21204147
78Follicular hyperkeratosis (HP:0007502)2.20948021
79Abnormality of monocarboxylic acid metabolism (HP:0010996)2.19744958
80Interstitial pulmonary disease (HP:0006530)2.19044686
81Nephritis (HP:0000123)2.17565400
82Congenital, generalized hypertrichosis (HP:0004540)2.17440947
83Type 1 muscle fiber predominance (HP:0003803)2.15075362
84Premature rupture of membranes (HP:0001788)2.14244501
85Abnormality of carpal bone ossification (HP:0006257)2.13304975
86Hydroxyprolinuria (HP:0003080)2.12216676
87Abnormality of proline metabolism (HP:0010907)2.12216676
88Protrusio acetabuli (HP:0003179)2.11936189
89Mildly elevated creatine phosphokinase (HP:0008180)2.11691448
90Wrist flexion contracture (HP:0001239)2.10526313
91Advanced eruption of teeth (HP:0006288)2.07513895
92Abdominal distention (HP:0003270)2.06126088
93Cervical subluxation (HP:0003308)2.05935384
94Abnormality of chloride homeostasis (HP:0011422)2.04781617
95Flattened epiphyses (HP:0003071)2.04494724
96Lower limb amyotrophy (HP:0007210)2.03660832
97Premature loss of primary teeth (HP:0006323)2.01243733
98Deviation of the thumb (HP:0009603)2.01078687
99Hypoplasia of dental enamel (HP:0006297)2.00793679
100Ankle contracture (HP:0006466)2.00406225
101Ventricular fibrillation (HP:0001663)1.99991265
102Hoarse voice (HP:0001609)1.98581309
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.98571696
104Osteolytic defects of the hand bones (HP:0009699)1.98571696
105Hyperkalemia (HP:0002153)1.98159207
106Abnormality of renin-angiotensin system (HP:0000847)1.97789056
107Dehydration (HP:0001944)1.97434280
108Hyporeflexia of lower limbs (HP:0002600)1.97271138
109Abnormality of the salivary glands (HP:0010286)1.96969112
110Xanthomatosis (HP:0000991)1.96134480
111Spinal cord compression (HP:0002176)1.96131896
112Abnormal ossification of hand bones (HP:0005921)1.96128315
113Hypoalphalipoproteinemia (HP:0003233)1.93288252
114Cheilitis (HP:0100825)1.92144808
115Aortic aneurysm (HP:0004942)1.91395635
116Natal tooth (HP:0000695)1.91306105
117Ureteral stenosis (HP:0000071)1.90092998
118Amelogenesis imperfecta (HP:0000705)1.88105834
119Abnormal cartilage morphology (HP:0002763)1.87363081
120Short phalanx of the thumb (HP:0009660)1.86597155
121Oligodontia (HP:0000677)1.85284527
122Mesangial abnormality (HP:0001966)1.85026293
123Curly hair (HP:0002212)1.82736641
124Rectal prolapse (HP:0002035)1.82614182
125Autoimmune thrombocytopenia (HP:0001973)1.82592280
126Popliteal pterygium (HP:0009756)1.81828042
127Abnormal hair laboratory examination (HP:0003328)1.81701162
128Vertebral hypoplasia (HP:0008417)1.80696866
129Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80696866
130Erythema (HP:0010783)1.79948547
131Neonatal death (HP:0003811)1.79897130
132Hyponatremia (HP:0002902)1.78597253
133Dysostosis multiplex (HP:0000943)1.77715306
134Breech presentation (HP:0001623)1.77380577
135Absent phalangeal crease (HP:0006109)1.76918229
136Abnormal vertebral ossification (HP:0100569)1.76139406
137Multifactorial inheritance (HP:0001426)1.75645792
138Blepharitis (HP:0000498)1.73860729
139Abnormal hand bone ossification (HP:0010660)1.72814453
140Conjugated hyperbilirubinemia (HP:0002908)1.72264899
141Parakeratosis (HP:0001036)1.72037927
142Hyperparathyroidism (HP:0000843)1.71978723
143Ectropion (HP:0000656)1.71731824
144Proximal placement of thumb (HP:0009623)1.71650207
145Decreased circulating renin level (HP:0003351)1.71053252
146Nasal polyposis (HP:0100582)1.69473956
147Bone pain (HP:0002653)1.69270199
148Abnormality of the gastric mucosa (HP:0004295)1.69050285
149Gastrointestinal dysmotility (HP:0002579)1.68949993
150Reduced subcutaneous adipose tissue (HP:0003758)1.68921266
151Ureteral obstruction (HP:0006000)1.68138699
152Growth hormone excess (HP:0000845)1.66133420
153Difficulty climbing stairs (HP:0003551)1.65173300
154Progressive hearing impairment (HP:0001730)1.64782487
155Polar cataract (HP:0010696)1.64185108
156Progressive sensorineural hearing impairment (HP:0000408)1.64179080
157Sparse scalp hair (HP:0002209)1.61741799
158Diaphragmatic weakness (HP:0009113)1.60931460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA5.89496940
2MAP3K24.14692637
3KSR23.46654819
4MAP2K23.06172545
5EPHB23.00244623
6NME12.76897621
7* MET2.66207172
8TRIB32.63473172
9RIPK12.58292801
10FRK2.44980579
11LMTK22.38984371
12IRAK32.21909835
13ERN12.18187885
14MST42.02805706
15MAP2K12.01707970
16EPHA21.96460049
17EEF2K1.90248725
18CAMK1D1.89522560
19MAP3K11.84537114
20TTN1.77943084
21FER1.76291708
22SMG11.74265916
23MAPKAPK31.70701544
24NME21.61327958
25MYLK1.58618574
26PTK61.57723816
27ICK1.55135856
28EPHB11.40987202
29MAP3K111.36368418
30MAP3K31.28143599
31PKN21.27862242
32CAMK1G1.27329763
33DMPK1.22748645
34STK391.21772371
35CDK121.21458311
36MAP3K121.17171671
37RET1.10892241
38EPHA31.08098147
39TGFBR21.06208765
40LRRK21.03037289
41PRKG21.02931832
42FGFR41.00886835
43BMX0.99486786
44CDK90.98621313
45RIPK40.98503886
46PTK20.98022447
47LATS10.97137240
48PIK3CG0.94207301
49MAP3K70.94193503
50TRPM70.93214931
51TESK10.92570476
52RPS6KB20.91612521
53FGFR20.91311621
54MAP3K60.87307242
55PBK0.84971039
56STK100.84928792
57GRK60.84340857
58CDC42BPA0.83837106
59SIK10.83187027
60DDR20.82399480
61PRPF4B0.76667405
62MTOR0.75480929
63NTRK10.75084774
64STK240.74930244
65WNK40.74714875
66SIK30.74614019
67TAOK10.74567670
68MAP3K100.73252270
69PRKAA20.71662803
70FGFR30.68980225
71MAP3K80.67913406
72CAMK2D0.65248346
73PDK20.64624284
74BLK0.63187519
75TYK20.62833294
76PDK30.61830947
77PDK40.61830947
78FGFR10.61739200
79MAP3K90.59838518
80JAK20.56919693
81PDGFRA0.56388300
82STK380.55571722
83TESK20.54477095
84ILK0.53164209
85EIF2AK10.51989134
86MAPK150.51885960
87ERBB20.50447880
88CSK0.50205740
89DAPK20.49992166
90ACVR1B0.49574901
91* MST1R0.48968253
92PDPK10.48743096
93NUAK10.47716602
94TAOK30.46836971
95PRKD20.46244469
96PAK40.45721222
97NEK60.45241567
98CDK80.44807388
99SRC0.44572098
100ARAF0.43540747
101MAPKAPK20.42003524
102PAK20.41286557
103MELK0.40715549
104WNK10.39866611
105CDK70.38578756
106RPS6KA20.38191945
107LIMK10.37438709
108NEK20.37238848
109MAPKAPK50.37175094
110MAP3K130.37114843
111MATK0.36657204
112CSF1R0.35606381
113DAPK30.35110889
114PIM20.35054307
115PRKCH0.31291350
116ZAP700.30988546
117MAPK110.30861221
118MAP2K60.30720029
119PRKCI0.30257915
120ROCK10.30151542
121TBK10.30104081
122MARK20.29057990
123PTK2B0.28607716
124ABL20.27103979
125CHUK0.26210618
126OXSR10.26160771
127PDK10.24019757
128TGFBR10.23652750
129IRAK20.23611322
130DAPK10.23178060
131PRKD10.22902317
132RPS6KA10.22804699
133LATS20.22785322
134ERBB40.22260589
135STK38L0.22232339
136PDGFRB0.22000185
137TTK0.21745544

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.72043114
2Sulfur metabolism_Homo sapiens_hsa009203.67359869
3Fat digestion and absorption_Homo sapiens_hsa049753.18259603
4Staphylococcus aureus infection_Homo sapiens_hsa051502.71574029
5Caffeine metabolism_Homo sapiens_hsa002322.57416233
6Arginine biosynthesis_Homo sapiens_hsa002202.45710069
7Linoleic acid metabolism_Homo sapiens_hsa005912.26538608
8Other glycan degradation_Homo sapiens_hsa005111.99983400
9Arachidonic acid metabolism_Homo sapiens_hsa005901.96360680
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80617554
11PPAR signaling pathway_Homo sapiens_hsa033201.74240147
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62041432
13Protein digestion and absorption_Homo sapiens_hsa049741.60709902
14Notch signaling pathway_Homo sapiens_hsa043301.60701237
15Bile secretion_Homo sapiens_hsa049761.55469177
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55299574
17Pertussis_Homo sapiens_hsa051331.53131318
18Glycerolipid metabolism_Homo sapiens_hsa005611.50973401
19Renin-angiotensin system_Homo sapiens_hsa046141.50814836
20Thyroid cancer_Homo sapiens_hsa052161.49512095
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.48847298
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42120777
23ECM-receptor interaction_Homo sapiens_hsa045121.41003385
24Sulfur relay system_Homo sapiens_hsa041221.38380698
25Histidine metabolism_Homo sapiens_hsa003401.37042816
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24094368
27Amoebiasis_Homo sapiens_hsa051461.19364340
28Bladder cancer_Homo sapiens_hsa052191.18100920
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15921561
30Sphingolipid metabolism_Homo sapiens_hsa006001.15676899
31Pentose phosphate pathway_Homo sapiens_hsa000301.15240625
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15228475
33Biosynthesis of amino acids_Homo sapiens_hsa012301.12788008
34Salivary secretion_Homo sapiens_hsa049701.12288293
35Vitamin digestion and absorption_Homo sapiens_hsa049771.11941123
36Galactose metabolism_Homo sapiens_hsa000521.11447909
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10307724
38Adherens junction_Homo sapiens_hsa045201.10021030
39Complement and coagulation cascades_Homo sapiens_hsa046101.09538523
40Arginine and proline metabolism_Homo sapiens_hsa003301.08764402
41Fatty acid biosynthesis_Homo sapiens_hsa000611.03447285
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01735368
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01554145
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01000229
45Tight junction_Homo sapiens_hsa045300.98226592
46Retinol metabolism_Homo sapiens_hsa008300.94235105
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93674551
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.93079680
49N-Glycan biosynthesis_Homo sapiens_hsa005100.92570369
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91583390
51Pancreatic secretion_Homo sapiens_hsa049720.91537544
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.90742904
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90058867
54Chronic myeloid leukemia_Homo sapiens_hsa052200.87798172
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.87699126
56Fatty acid degradation_Homo sapiens_hsa000710.86435827
57Starch and sucrose metabolism_Homo sapiens_hsa005000.86193019
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86129662
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85446483
60ABC transporters_Homo sapiens_hsa020100.85058581
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83226644
62Proteoglycans in cancer_Homo sapiens_hsa052050.78383910
63Toxoplasmosis_Homo sapiens_hsa051450.78025768
64Gastric acid secretion_Homo sapiens_hsa049710.77890311
65Glutathione metabolism_Homo sapiens_hsa004800.77169278
66Fructose and mannose metabolism_Homo sapiens_hsa000510.74867144
67VEGF signaling pathway_Homo sapiens_hsa043700.73334393
68Focal adhesion_Homo sapiens_hsa045100.71082773
69Leishmaniasis_Homo sapiens_hsa051400.69732237
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.68097819
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.67620969
72Prion diseases_Homo sapiens_hsa050200.67336258
73Inositol phosphate metabolism_Homo sapiens_hsa005620.66948605
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66755866
75Salmonella infection_Homo sapiens_hsa051320.65940940
76Tyrosine metabolism_Homo sapiens_hsa003500.65878936
77Insulin signaling pathway_Homo sapiens_hsa049100.64076211
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63844821
79Vibrio cholerae infection_Homo sapiens_hsa051100.63198181
80Chemical carcinogenesis_Homo sapiens_hsa052040.63072687
81Pancreatic cancer_Homo sapiens_hsa052120.62608089
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.62473860
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61367845
84GnRH signaling pathway_Homo sapiens_hsa049120.61364816
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61219048
86Carbon metabolism_Homo sapiens_hsa012000.61187945
87Phenylalanine metabolism_Homo sapiens_hsa003600.60978958
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60022729
89Hepatitis C_Homo sapiens_hsa051600.58660193
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58358490
91ErbB signaling pathway_Homo sapiens_hsa040120.57569852
92Platelet activation_Homo sapiens_hsa046110.56706814
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.56558311
94Fatty acid metabolism_Homo sapiens_hsa012120.56205935
95Dorso-ventral axis formation_Homo sapiens_hsa043200.56115753
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.55900700
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55762020
98Endocytosis_Homo sapiens_hsa041440.53065537
99Renin secretion_Homo sapiens_hsa049240.52370000
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52206376
101Thyroid hormone synthesis_Homo sapiens_hsa049180.51919101
102Apoptosis_Homo sapiens_hsa042100.50071257
103Influenza A_Homo sapiens_hsa051640.49987760
104Glucagon signaling pathway_Homo sapiens_hsa049220.46401515
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44884029
106Basal cell carcinoma_Homo sapiens_hsa052170.44726629
107Tryptophan metabolism_Homo sapiens_hsa003800.44563717
108Pyruvate metabolism_Homo sapiens_hsa006200.44544806
109Hedgehog signaling pathway_Homo sapiens_hsa043400.44308675
110Malaria_Homo sapiens_hsa051440.44152165
111beta-Alanine metabolism_Homo sapiens_hsa004100.44118091
112AMPK signaling pathway_Homo sapiens_hsa041520.43466299
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43254522
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40922365
115Melanogenesis_Homo sapiens_hsa049160.40583080
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38779689
117Endometrial cancer_Homo sapiens_hsa052130.38775305
118Folate biosynthesis_Homo sapiens_hsa007900.38555088
119Choline metabolism in cancer_Homo sapiens_hsa052310.36067578
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35779601
121Insulin resistance_Homo sapiens_hsa049310.35649046
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34997276
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34668911
124Small cell lung cancer_Homo sapiens_hsa052220.34461322
125Acute myeloid leukemia_Homo sapiens_hsa052210.33304897
126Osteoclast differentiation_Homo sapiens_hsa043800.32610437
127MicroRNAs in cancer_Homo sapiens_hsa052060.31830099
128TGF-beta signaling pathway_Homo sapiens_hsa043500.30694461
129Axon guidance_Homo sapiens_hsa043600.30215908
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29581643
131Type II diabetes mellitus_Homo sapiens_hsa049300.29192787
132Dilated cardiomyopathy_Homo sapiens_hsa054140.28470210
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28253677
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28228644

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