MSS51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.85207425
2actin-myosin filament sliding (GO:0033275)9.85207425
3regulation of skeletal muscle contraction (GO:0014819)9.18621312
4skeletal muscle contraction (GO:0003009)8.99416253
5skeletal muscle adaptation (GO:0043501)8.18209794
6actin-mediated cell contraction (GO:0070252)8.13319170
7regulation of relaxation of muscle (GO:1901077)8.08798903
8snRNA transcription (GO:0009301)7.95605103
9sarcoplasmic reticulum calcium ion transport (GO:0070296)7.94813765
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.78130433
11negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 6.74684438
12dosage compensation (GO:0007549)6.70673475
13centriole replication (GO:0007099)6.63180256
14skeletal muscle fiber development (GO:0048741)6.49112156
15barbed-end actin filament capping (GO:0051016)6.34851112
16actin filament-based movement (GO:0030048)6.29168628
17response to inactivity (GO:0014854)6.18575104
18regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 6.16293772
19myotube cell development (GO:0014904)5.47350574
20glycogen catabolic process (GO:0005980)5.46554624
21purine nucleotide salvage (GO:0032261)5.39044773
22cardiac myofibril assembly (GO:0055003)5.36804502
23mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.34617292
24positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.34617292
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.31237584
26creatine metabolic process (GO:0006600)5.20454464
27IMP metabolic process (GO:0046040)5.15464947
28regulation of centriole replication (GO:0046599)5.10473709
29glucan catabolic process (GO:0009251)5.09205227
30cornea development in camera-type eye (GO:0061303)5.02472488
31negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)5.00422534
32cardiac muscle contraction (GO:0060048)4.98139576
33striated muscle contraction (GO:0006941)4.97475253
34sarcomere organization (GO:0045214)4.90984818
35negative regulation of skeletal muscle tissue development (GO:0048642)4.84894302
36striated muscle atrophy (GO:0014891)4.81148052
37response to muscle activity (GO:0014850)4.73128891
38cellular polysaccharide catabolic process (GO:0044247)4.72649002
39skeletal muscle tissue development (GO:0007519)4.71454836
40regulation of double-strand break repair via homologous recombination (GO:0010569)4.70566090
41plasma membrane repair (GO:0001778)4.65430308
42skeletal muscle tissue regeneration (GO:0043403)4.60204293
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.53379943
44regulation of actin filament-based movement (GO:1903115)4.46282863
45regulation of cell communication by electrical coupling (GO:0010649)4.41766622
46polysaccharide catabolic process (GO:0000272)4.39907506
47centriole assembly (GO:0098534)4.37913721
48IMP biosynthetic process (GO:0006188)4.33875054
49regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.32248463
50cardiac muscle hypertrophy (GO:0003300)4.27835200
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.22129285
52myofibril assembly (GO:0030239)4.21091318
53ribonucleoprotein complex disassembly (GO:0032988)4.17748542
54glycogen biosynthetic process (GO:0005978)4.17245068
55glucan biosynthetic process (GO:0009250)4.17245068
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.11335396
57cellular response to dexamethasone stimulus (GO:0071549)4.09595477
58striated muscle adaptation (GO:0014888)4.08543379
59striated muscle hypertrophy (GO:0014897)4.08360043
60muscle atrophy (GO:0014889)4.07083206
61muscle cell cellular homeostasis (GO:0046716)4.02874325
62muscle contraction (GO:0006936)4.02534376
63pyrimidine ribonucleoside catabolic process (GO:0046133)4.01910529
64neuronal action potential propagation (GO:0019227)4.01457541
65negative regulation of potassium ion transmembrane transport (GO:1901380)3.92812062
66positive regulation of mitochondrial membrane permeability (GO:0035794)3.92429219
67positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.88261153
68regulation of striated muscle contraction (GO:0006942)3.86054658
69response to dexamethasone (GO:0071548)3.84634618
70muscle structure development (GO:0061061)3.84315461
71ubiquinone biosynthetic process (GO:0006744)3.84311422
72cytoplasmic microtubule organization (GO:0031122)3.83441498
73regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.82375071
74negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.81444429
75muscle organ development (GO:0007517)3.81267705
76negative regulation of muscle hypertrophy (GO:0014741)3.78757717
77carnitine shuttle (GO:0006853)3.77989760
78striated muscle cell development (GO:0055002)3.75674018
792-oxoglutarate metabolic process (GO:0006103)3.75297945
80cytidine deamination (GO:0009972)3.74640925
81cytidine metabolic process (GO:0046087)3.74640925
82cytidine catabolic process (GO:0006216)3.74640925
83negative regulation of transcription regulatory region DNA binding (GO:2000678)3.73470700
84negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.72804205
85negative regulation of calcium ion transmembrane transport (GO:1903170)3.72804205
86muscle organ morphogenesis (GO:0048644)3.72330117
87glial cell proliferation (GO:0014009)3.67937994
88regulation of calcium ion transmembrane transporter activity (GO:1901019)3.66523535
89regulation of calcium ion transmembrane transport (GO:1903169)3.66523535
90muscle hypertrophy (GO:0014896)3.65873088
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.65271953
92fructose metabolic process (GO:0006000)3.64220409
93muscle cell fate commitment (GO:0042693)3.63311272
94positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.62543962
95neuromuscular synaptic transmission (GO:0007274)3.60527250
96NADH metabolic process (GO:0006734)3.59274021
97adult heart development (GO:0007512)3.58916948
98eyelid development in camera-type eye (GO:0061029)3.58427615
99synaptonemal complex assembly (GO:0007130)3.56039072
100muscle system process (GO:0003012)3.55090073
101muscle tissue morphogenesis (GO:0060415)3.54255664
102regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50692416
103synaptonemal complex organization (GO:0070193)3.49898951
104actomyosin structure organization (GO:0031032)3.49325705
105regulation of acyl-CoA biosynthetic process (GO:0050812)3.49250896
106muscle fiber development (GO:0048747)3.48328040
107glycogen metabolic process (GO:0005977)3.48299564
108myoblast fusion (GO:0007520)3.45921696
109somite development (GO:0061053)3.44729644
110male genitalia development (GO:0030539)3.44203592
111glucan metabolic process (GO:0044042)3.40501623
112cellular glucan metabolic process (GO:0006073)3.40501623
113negative regulation of glial cell proliferation (GO:0060253)3.40295590
114ubiquinone metabolic process (GO:0006743)3.38107153
115cellular carbohydrate catabolic process (GO:0044275)3.34467472
116cardiac muscle tissue morphogenesis (GO:0055008)3.34286679
117regulation of sequestering of triglyceride (GO:0010889)3.33846536
118positive regulation of myotube differentiation (GO:0010831)3.33455627
119otic vesicle formation (GO:0030916)3.33382395
120regulation of sarcomere organization (GO:0060297)3.32003643
121regulation of hexokinase activity (GO:1903299)3.30021131
122regulation of glucokinase activity (GO:0033131)3.30021131
123cardiac muscle cell development (GO:0055013)3.29705406
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29316144
125gluconeogenesis (GO:0006094)3.28571115
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.28156899
127myotube differentiation (GO:0014902)3.28008098
128organelle disassembly (GO:1903008)3.27524512
129fatty acid transmembrane transport (GO:1902001)3.27129761
130regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.24708105
131striated muscle tissue development (GO:0014706)3.23776014
132regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.23468242
133negative regulation of muscle contraction (GO:0045932)3.21447321
134negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.20477310
135muscle adaptation (GO:0043500)3.20289559
136positive regulation of cation channel activity (GO:2001259)3.19640133
137muscle cell development (GO:0055001)3.19033575
138cardiac ventricle formation (GO:0003211)3.16751240
139positive regulation of myoblast differentiation (GO:0045663)3.16267632
140regulation of membrane repolarization (GO:0060306)3.15771696
141homeostasis of number of cells within a tissue (GO:0048873)3.13340659
142heart process (GO:0003015)3.12796308
143heart contraction (GO:0060047)3.12796308
144negative regulation of signal transduction by p53 class mediator (GO:1901797)3.12044378
145receptor guanylyl cyclase signaling pathway (GO:0007168)3.11621319
146skeletal muscle cell differentiation (GO:0035914)3.11081009
147positive regulation of DNA-templated transcription, elongation (GO:0032786)3.09284284
148positive regulation of Rho protein signal transduction (GO:0035025)3.04544277
149regulation of hippo signaling (GO:0035330)3.03641657
150regulation of cofactor metabolic process (GO:0051193)3.03371393
151regulation of coenzyme metabolic process (GO:0051196)3.03371393
152response to activity (GO:0014823)3.01189589
153protein localization to chromosome (GO:0034502)2.99530609
154cellular response to virus (GO:0098586)2.99495398
155modulation by virus of host process (GO:0019054)2.97400225
156sequestering of actin monomers (GO:0042989)12.6416136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.54374840
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.51563636
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.77768065
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26657094
5EZH2_22144423_ChIP-Seq_EOC_Human3.15737117
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10614669
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.91060159
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88597881
9VDR_22108803_ChIP-Seq_LS180_Human2.62021643
10IGF1R_20145208_ChIP-Seq_DFB_Human2.57431054
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57348891
12BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.40050177
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36869627
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.30184946
15ZNF274_21170338_ChIP-Seq_K562_Hela2.29378855
16GBX2_23144817_ChIP-Seq_PC3_Human2.15613770
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.09450576
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.06168781
19DROSHA_22980978_ChIP-Seq_HELA_Human2.03898823
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00557842
21TDRD3_21172665_ChIP-Seq_MCF-7_Human1.99068393
22NFIB_24661679_ChIP-Seq_LUNG_Mouse1.87208779
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.85821373
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85164197
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76759497
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75976351
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75714327
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75520386
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63360949
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60974344
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59665315
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.59557317
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57743605
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.56777177
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.56777177
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56624966
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.54500099
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53314178
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52390675
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52012276
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51347429
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.50290495
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49854853
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.49538329
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.48389649
46AR_21572438_ChIP-Seq_LNCaP_Human1.47177650
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.43361817
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.39933472
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39845547
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37575854
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36906014
52CBP_20019798_ChIP-Seq_JUKART_Human1.36679222
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36679222
54SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.36601514
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36031691
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.35449238
57ZNF263_19887448_ChIP-Seq_K562_Human1.31727432
58TCF7_22412390_ChIP-Seq_EML_Mouse1.31287674
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.31275888
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30689058
61OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30457824
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30316716
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28796341
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.28488500
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27844310
66OCT4_20526341_ChIP-Seq_ESCs_Human1.26059800
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25336740
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25239549
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23809896
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23809896
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.21994791
72FUS_26573619_Chip-Seq_HEK293_Human1.19055905
73NANOG_19829295_ChIP-Seq_ESCs_Human1.18532641
74SOX2_19829295_ChIP-Seq_ESCs_Human1.18532641
75ER_23166858_ChIP-Seq_MCF-7_Human1.18514307
76AHR_22903824_ChIP-Seq_MCF-7_Human1.18374857
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17626942
78TAF15_26573619_Chip-Seq_HEK293_Human1.17486249
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17409030
80MYC_27129775_Chip-Seq_CORNEA_Mouse1.17319068
81CEBPB_22108803_ChIP-Seq_LS180_Human1.11621903
82KDM2B_26808549_Chip-Seq_DND41_Human1.10419446
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08943860
84GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08925949
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08261085
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07717988
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07177507
88FOXH1_21741376_ChIP-Seq_EPCs_Human1.07035920
89TP53_22573176_ChIP-Seq_HFKS_Human1.06923987
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05705166
91SMAD4_21799915_ChIP-Seq_A2780_Human1.05501159
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04369191
93TCF4_23295773_ChIP-Seq_U87_Human1.03642787
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.03456734
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03421168
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03235096
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02898981
98GATA3_21867929_ChIP-Seq_TH1_Mouse1.02858557
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01136119
100GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00811034
101NANOG_20526341_ChIP-Seq_ESCs_Human0.99698708
102HTT_18923047_ChIP-ChIP_STHdh_Human0.98966743
103CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98496638
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98456448
105GF1_26923725_Chip-Seq_HPCs_Mouse0.97677949
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.97045574
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96461199
108STAT1_20625510_ChIP-Seq_HELA_Human0.96441902
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96152468
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96019751
111CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94639406
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.94134285
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93930881
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93823525
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.93548134
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93436204
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.92613667
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92240812
119BCL6_27268052_Chip-Seq_Bcells_Human0.92162457
120PHF8_20622853_ChIP-Seq_HELA_Human0.91495677
121GATA6_21074721_ChIP-Seq_CACO-2_Human0.91064108
122LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.90763661
123CTCF_27219007_Chip-Seq_Bcells_Human0.90523445
124UTX_26944678_Chip-Seq_JUKART_Human0.90322760
125P53_21459846_ChIP-Seq_SAOS-2_Human0.90121258
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89991966
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89645768
128RING1B_27294783_Chip-Seq_ESCs_Mouse0.89457466
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.89120724
130PHF8_20622854_ChIP-Seq_HELA_Human0.88920873
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88562299
132NFYB_21822215_ChIP-Seq_K562_Human0.88313301
133STAT3_23295773_ChIP-Seq_U87_Human0.88240667
134GF1B_26923725_Chip-Seq_HPCs_Mouse0.88022213
135KDM2B_26808549_Chip-Seq_K562_Human0.87396205
136CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87313772
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87160721
138NCOR_22424771_ChIP-Seq_293T_Human0.87124639
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.86573467
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.85759974
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85430252
142P53_22387025_ChIP-Seq_ESCs_Mouse0.85184569
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85070320
144ETV1_20927104_ChIP-Seq_GIST48_Human0.84915914
145SPI1_20517297_ChIP-Seq_HL60_Human0.84858151
146AR_25329375_ChIP-Seq_VCAP_Human0.84656876
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84607788
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84586388
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.84460427
150ERA_21632823_ChIP-Seq_H3396_Human0.84324971
151CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84086244
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83320005
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83320005
154FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83080209
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.82550494
156CBP_21632823_ChIP-Seq_H3396_Human0.82478135
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81049397
158MYC_19829295_ChIP-Seq_ESCs_Human0.80974310
159SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80960683
160TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80524365
161HOXB7_26014856_ChIP-Seq_BT474_Human0.80325483
162GATA1_19941826_ChIP-Seq_K562_Human0.80293716
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.80154296
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79668822
165TBL1_22424771_ChIP-Seq_293T_Human0.79665825
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79557777
167SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79550754
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79101936
169RAC3_21632823_ChIP-Seq_H3396_Human0.78764343
170BCOR_27268052_Chip-Seq_Bcells_Human0.77354581
171PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76136374
172CREB1_26743006_Chip-Seq_LNCaP_Human0.76087183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.01435727
2MP0003787_abnormal_imprinting6.20585100
3MP0000749_muscle_degeneration4.85388944
4MP0003646_muscle_fatigue4.75300162
5MP0000751_myopathy4.25242011
6MP0002106_abnormal_muscle_physiology3.79094302
7MP0000747_muscle_weakness3.71034354
8MP0000759_abnormal_skeletal_muscle3.54967067
9MP0004036_abnormal_muscle_relaxation3.41841612
10MP0008877_abnormal_DNA_methylation3.24001496
11MP0005369_muscle_phenotype3.16396838
12MP0008789_abnormal_olfactory_epithelium3.06699582
13MP0002269_muscular_atrophy3.06606210
14MP0004130_abnormal_muscle_cell2.96158594
15MP0005451_abnormal_body_composition2.94617098
16MP0005187_abnormal_penis_morphology2.92168813
17MP0004087_abnormal_muscle_fiber2.80815157
18MP0005620_abnormal_muscle_contractility2.65765268
19MP0000733_abnormal_muscle_development2.45502797
20MP0002837_dystrophic_cardiac_calcinosis2.36172001
21MP0004233_abnormal_muscle_weight2.25332877
22MP0003121_genomic_imprinting2.23353056
23MP0004134_abnormal_chest_morphology2.21040117
24MP0000750_abnormal_muscle_regeneration2.19408167
25MP0005499_abnormal_olfactory_system1.94625499
26MP0005394_taste/olfaction_phenotype1.94625499
27MP0002108_abnormal_muscle_morphology1.78058009
28MP0000013_abnormal_adipose_tissue1.75362781
29MP0004270_analgesia1.72143399
30MP0002822_catalepsy1.56603385
31MP0000647_abnormal_sebaceous_gland1.38201711
32MP0002332_abnormal_exercise_endurance1.37043109
33MP0004510_myositis1.30206123
34MP0003806_abnormal_nucleotide_metabolis1.29980139
35MP0009250_abnormal_appendicular_skeleto1.25099553
36MP0002127_abnormal_cardiovascular_syste1.23365698
37MP0004185_abnormal_adipocyte_glucose1.22135488
38MP0004147_increased_porphyrin_level1.20705539
39MP0008058_abnormal_DNA_repair1.17707265
40MP0006036_abnormal_mitochondrial_physio1.14041664
41MP0003950_abnormal_plasma_membrane1.12812630
42MP0005330_cardiomyopathy1.11435461
43MP0006138_congestive_heart_failure1.09335984
44MP0002971_abnormal_brown_adipose1.08070283
45MP0008775_abnormal_heart_ventricle1.06902404
46MP0003385_abnormal_body_wall1.04466914
47MP0009672_abnormal_birth_weight1.01435383
48MP0004142_abnormal_muscle_tone0.94109343
49MP0002009_preneoplasia0.90841766
50MP0003137_abnormal_impulse_conducting0.88859472
51MP0002876_abnormal_thyroid_physiology0.87890688
52MP0004043_abnormal_pH_regulation0.87849497
53MP0003879_abnormal_hair_cell0.87360271
54MP0002089_abnormal_postnatal_growth/wei0.86372295
55MP0003045_fibrosis0.85186475
56MP0001661_extended_life_span0.84111005
57MP0005257_abnormal_intraocular_pressure0.83757742
58MP0002932_abnormal_joint_morphology0.83661167
59MP0003221_abnormal_cardiomyocyte_apopto0.83482370
60MP0004085_abnormal_heartbeat0.82976079
61MP0002233_abnormal_nose_morphology0.80916160
62MP0004215_abnormal_myocardial_fiber0.78290879
63MP0000003_abnormal_adipose_tissue0.76191951
64MP0001324_abnormal_eye_pigmentation0.72240058
65MP0009780_abnormal_chondrocyte_physiolo0.71321371
66MP0005375_adipose_tissue_phenotype0.68479250
67MP0010630_abnormal_cardiac_muscle0.67657807
68MP0005334_abnormal_fat_pad0.67533068
69MP0009703_decreased_birth_body0.66383649
70MP0002972_abnormal_cardiac_muscle0.66215367
71MP0002638_abnormal_pupillary_reflex0.65234124
72MP0001293_anophthalmia0.64993344
73MP0004484_altered_response_of0.63629148
74MP0004084_abnormal_cardiac_muscle0.63302597
75MP0005666_abnormal_adipose_tissue0.63266845
76MP0003656_abnormal_erythrocyte_physiolo0.62851986
77MP0002249_abnormal_larynx_morphology0.60717762
78MP0003195_calcinosis0.56660068
79MP0000266_abnormal_heart_morphology0.55989838
80MP0002078_abnormal_glucose_homeostasis0.54468795
81MP0005197_abnormal_uvea_morphology0.53888192
82MP0006035_abnormal_mitochondrial_morpho0.53195576
83MP0001544_abnormal_cardiovascular_syste0.52976658
84MP0005385_cardiovascular_system_phenoty0.52976658
85MP0003763_abnormal_thymus_physiology0.52897538
86MP0001727_abnormal_embryo_implantation0.52747042
87MP0003755_abnormal_palate_morphology0.52424150
88MP0005167_abnormal_blood-brain_barrier0.51988620
89MP0000762_abnormal_tongue_morphology0.50657975
90MP0002114_abnormal_axial_skeleton0.49995949
91MP0005266_abnormal_metabolism0.49728848
92MP0002132_abnormal_respiratory_system0.49601545
93MP0005386_behavior/neurological_phenoty0.48653716
94MP0004924_abnormal_behavior0.48653716
95MP0000230_abnormal_systemic_arterial0.47960176
96MP0002184_abnormal_innervation0.47821631
97MP0005535_abnormal_body_temperature0.46240645
98MP0003828_pulmonary_edema0.45345113
99MP0000372_irregular_coat_pigmentation0.43615245
100MP0002751_abnormal_autonomic_nervous0.42779075
101MP0003948_abnormal_gas_homeostasis0.42719991
102MP0001485_abnormal_pinna_reflex0.41230603
103MP0005645_abnormal_hypothalamus_physiol0.40624751
104MP0002081_perinatal_lethality0.40566194
105MP0005332_abnormal_amino_acid0.40543625
106MP0005083_abnormal_biliary_tract0.40102638
107MP0002734_abnormal_mechanical_nocicepti0.40042584
108MP0003705_abnormal_hypodermis_morpholog0.39079827
109MP0005423_abnormal_somatic_nervous0.38990495
110MP0005376_homeostasis/metabolism_phenot0.38275257
111MP0004133_heterotaxia0.37858606
112MP0004808_abnormal_hematopoietic_stem0.37551213
113MP0001346_abnormal_lacrimal_gland0.37462898
114MP0002234_abnormal_pharynx_morphology0.37183571
115MP0000049_abnormal_middle_ear0.37145297
116MP0002877_abnormal_melanocyte_morpholog0.37144568
117MP0006276_abnormal_autonomic_nervous0.37096468
118MP0002109_abnormal_limb_morphology0.36915722
119MP0002067_abnormal_sensory_capabilities0.35865606
120MP0005365_abnormal_bile_salt0.34730145
121MP0002272_abnormal_nervous_system0.34607711
122MP0008569_lethality_at_weaning0.34570440
123MP0010030_abnormal_orbit_morphology0.34324673
124MP0002933_joint_inflammation0.34170020
125MP0005084_abnormal_gallbladder_morpholo0.33927296
126MP0001986_abnormal_taste_sensitivity0.33607673
127MP0001440_abnormal_grooming_behavior0.33182921
128MP0009115_abnormal_fat_cell0.32687250
129MP0001984_abnormal_olfaction0.32261722
130MP0005584_abnormal_enzyme/coenzyme_acti0.31594799
131MP0005670_abnormal_white_adipose0.30803297
132MP0002066_abnormal_motor_capabilities/c0.30603132
133MP0002138_abnormal_hepatobiliary_system0.30572056
134MP0002896_abnormal_bone_mineralization0.30447587
135MP0001943_abnormal_respiration0.30211502
136MP0001286_abnormal_eye_development0.29491696
137MP0005452_abnormal_adipose_tissue0.29328749
138MP0001299_abnormal_eye_distance/0.28948673
139MP0002697_abnormal_eye_size0.28097472
140MP0010329_abnormal_lipoprotein_level0.28066421
141MP0001501_abnormal_sleep_pattern0.25947770
142MP0002163_abnormal_gland_morphology0.25644415
143MP0005319_abnormal_enzyme/_coenzyme0.25488148
144MP0003011_delayed_dark_adaptation0.25256765
145MP0002102_abnormal_ear_morphology0.25153880
146MP0008872_abnormal_physiological_respon0.23829565
147MP0005551_abnormal_eye_electrophysiolog0.23123776

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.96543644
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.62277152
3Exercise-induced myalgia (HP:0003738)8.01618217
4Nemaline bodies (HP:0003798)7.84928682
5Exercise-induced muscle cramps (HP:0003710)7.18343377
6Pelvic girdle muscle weakness (HP:0003749)7.08511608
7Abnormality of the hip-girdle musculature (HP:0001445)6.52652570
8Abnormality of the musculature of the pelvis (HP:0001469)6.52652570
9Distal arthrogryposis (HP:0005684)6.35092644
10Type 1 muscle fiber predominance (HP:0003803)6.32639104
11Ulnar deviation of the wrist (HP:0003049)6.20972285
12Muscle hypertrophy of the lower extremities (HP:0008968)6.14302264
13Myopathic facies (HP:0002058)5.93000881
14Round ear (HP:0100830)5.81637084
15Calf muscle hypertrophy (HP:0008981)5.35680167
16Calcaneovalgus deformity (HP:0001848)5.05133193
17Absent phalangeal crease (HP:0006109)4.72846438
18Muscle fiber splitting (HP:0003555)4.69674952
19Myoglobinuria (HP:0002913)4.59641046
20Deformed tarsal bones (HP:0008119)4.59564233
21Difficulty running (HP:0009046)4.47579645
22Muscle stiffness (HP:0003552)4.19938969
23Hyporeflexia of lower limbs (HP:0002600)4.11981817
24Abnormal finger flexion creases (HP:0006143)3.90277271
25Rhabdomyolysis (HP:0003201)3.87695319
26Limb-girdle muscle weakness (HP:0003325)3.85938999
27EMG: myopathic abnormalities (HP:0003458)3.85014376
28Increased connective tissue (HP:0009025)3.72029794
29Abnormality of the calf musculature (HP:0001430)3.33846457
30Abnormality of the left ventricular outflow tract (HP:0011103)3.32322113
31Subaortic stenosis (HP:0001682)3.32322113
32Rimmed vacuoles (HP:0003805)3.31971311
33Myotonia (HP:0002486)3.29808339
34Abnormality of skeletal muscle fiber size (HP:0012084)3.16356677
35Malignant hyperthermia (HP:0002047)3.11895695
36Shoulder girdle muscle weakness (HP:0003547)3.10077757
37Abnormality of the calcaneus (HP:0008364)3.06700815
38Frequent falls (HP:0002359)2.83168227
39Bundle branch block (HP:0011710)2.78033171
40Areflexia of lower limbs (HP:0002522)2.78014049
41Distal lower limb muscle weakness (HP:0009053)2.70491756
42Increased variability in muscle fiber diameter (HP:0003557)2.64628386
43Hyperkalemia (HP:0002153)2.62764467
44Slender build (HP:0001533)2.62557138
45Neck muscle weakness (HP:0000467)2.60932834
46Palpebral edema (HP:0100540)2.56640402
47Difficulty climbing stairs (HP:0003551)2.45791320
48Mesomelia (HP:0003027)2.34648628
49Bell-shaped thorax (HP:0001591)2.32294449
50Asymmetric septal hypertrophy (HP:0001670)2.31826290
51Insulin-resistant diabetes mellitus (HP:0000831)2.29163078
52Fatigable weakness (HP:0003473)2.28939148
53Abnormality of the neuromuscular junction (HP:0003398)2.28939148
54Foot dorsiflexor weakness (HP:0009027)2.25915056
55Abnormality of the intervertebral disk (HP:0005108)2.25080074
56Mask-like facies (HP:0000298)2.23275223
57Dilated cardiomyopathy (HP:0001644)2.21986902
58Progressive muscle weakness (HP:0003323)2.08702211
59Abnormality of the foot musculature (HP:0001436)2.05059578
60Hip contracture (HP:0003273)2.04943417
61Cone-rod dystrophy (HP:0000548)2.03938642
62Exercise intolerance (HP:0003546)2.02179894
63Ulnar deviation of finger (HP:0009465)1.98756708
64Waddling gait (HP:0002515)1.98559863
65Ventricular tachycardia (HP:0004756)1.98509597
66Nonprogressive disorder (HP:0003680)1.97580810
67Lipoatrophy (HP:0100578)1.97066831
68Fetal akinesia sequence (HP:0001989)1.96935365
69Metatarsus adductus (HP:0001840)1.96270282
70Distal lower limb amyotrophy (HP:0008944)1.95696638
71Hypoplastic ischia (HP:0003175)1.94819765
72Paralysis (HP:0003470)1.93580094
73Scapular winging (HP:0003691)1.93524938
74Abnormality of the shoulder girdle musculature (HP:0001435)1.91141972
75Proximal amyotrophy (HP:0007126)1.88912877
76Sudden death (HP:0001699)1.88385205
77Weak cry (HP:0001612)1.88040778
78Type 2 muscle fiber atrophy (HP:0003554)1.87843471
79Reduced subcutaneous adipose tissue (HP:0003758)1.87563107
80Febrile seizures (HP:0002373)1.85854517
81Wrist flexion contracture (HP:0001239)1.85703401
82Hyperuricemia (HP:0002149)1.85416738
83Increased purine levels (HP:0004368)1.85416738
84Heart block (HP:0012722)1.84882988
85Narrow face (HP:0000275)1.84378048
86Increased density of long bones (HP:0006392)1.83301148
87Bulbar palsy (HP:0001283)1.81992818
88Broad-based gait (HP:0002136)1.81301237
89Hypothermia (HP:0002045)1.80658534
90Abnormality of lateral ventricle (HP:0030047)1.80065474
91Atonic seizures (HP:0010819)1.79862275
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78537871
93Mildly elevated creatine phosphokinase (HP:0008180)1.78135149
94EMG: neuropathic changes (HP:0003445)1.76390382
95Spinal rigidity (HP:0003306)1.72728063
96Popliteal pterygium (HP:0009756)1.71628066
97Limb-girdle muscle atrophy (HP:0003797)1.68925296
98Respiratory insufficiency due to muscle weakness (HP:0002747)1.67539462
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67220462
100Muscle fiber atrophy (HP:0100295)1.65649578
101Abnormality of the ischium (HP:0003174)1.65400533
102Hypoalphalipoproteinemia (HP:0003233)1.64188135
103Abnormal atrioventricular conduction (HP:0005150)1.64095926
104Generalized muscle weakness (HP:0003324)1.62098214
105Increased intramyocellular lipid droplets (HP:0012240)1.61868108
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.61135893
107Oligomenorrhea (HP:0000876)1.61023974
108Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.57725196
109Muscular dystrophy (HP:0003560)1.57413781
110Anosmia (HP:0000458)1.54845237
111Stridor (HP:0010307)1.54135167
112Generalized tonic-clonic seizures (HP:0002069)1.51491516
113Long clavicles (HP:0000890)1.50948619
114Ventricular arrhythmia (HP:0004308)1.47412474
115Gowers sign (HP:0003391)1.45905370
116Increased muscle lipid content (HP:0009058)1.43669448
117Rocker bottom foot (HP:0001838)1.43314512
118Ragged-red muscle fibers (HP:0003200)1.42473248
119Hypochromic microcytic anemia (HP:0004840)1.42220451
120Facial diplegia (HP:0001349)1.42161100
121Abnormality of potassium homeostasis (HP:0011042)1.38691756
122Lower limb amyotrophy (HP:0007210)1.34301816
123Left ventricular hypertrophy (HP:0001712)1.33002044
124Limited hip movement (HP:0008800)1.29042214
125Steppage gait (HP:0003376)1.27498333
126Neonatal hypotonia (HP:0001319)1.26906047
127Acute necrotizing encephalopathy (HP:0006965)1.25768604
128Delayed gross motor development (HP:0002194)1.23831092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB38.55761443
2BMPR26.55564698
3PLK46.09867331
4OBSCN4.39266411
5TTN3.98936395
6INSRR3.78800363
7PHKG13.40657421
8PHKG23.40657421
9BLK3.05556263
10NME12.14888578
11PLK22.10180697
12CDK191.84510599
13NEK91.84092313
14MUSK1.80774557
15SIK21.68493460
16PIK3CG1.58270996
17MAPKAPK31.45104496
18FRK1.41883357
19MAP2K31.30674627
20MAP3K71.27201325
21SIK11.24400410
22MARK11.06459438
23MAP2K41.04225966
24DMPK0.91675100
25MAP4K20.91219057
26PIK3CA0.83743168
27SIK30.81987500
28TNK20.80729311
29CCNB10.76205926
30NEK10.74990452
31TRIB30.74968243
32MOS0.73033750
33CDK60.71807910
34MAPK120.71677132
35TGFBR20.70612999
36IRAK40.64510120
37CAMK10.63781668
38BMPR1B0.62028427
39PRKAA10.60728631
40EEF2K0.60654665
41DAPK20.58400895
42MAP2K60.58377441
43MAPK70.56183836
44ZAK0.55870808
45TNIK0.55415474
46OXSR10.52299958
47CAMK2A0.52043302
48TYK20.51519192
49BRD40.50094118
50TIE10.44962145
51MAP2K10.44924305
52MAP3K130.44813907
53MAP3K100.44608970
54PRKAA20.44010625
55CAMK1G0.43198007
56PDK20.42528648
57PRKACA0.41417126
58MAP3K60.40881717
59NTRK20.39708534
60ADRBK20.38873646
61PKN20.38819854
62GSK3A0.37529447
63TLK10.37300094
64BCKDK0.36718065
65AKT20.33446139
66CAMK2B0.32943151
67ROCK10.31660886
68MAPKAPK50.31172282
69TRPM70.30326877
70PNCK0.30102604
71STK40.29289520
72DYRK1B0.29266483
73GRK10.27563004
74SGK20.27492388
75CSF1R0.27020298
76STK240.26974872
77MAPK150.26919778
78PTK2B0.26798524
79ZAP700.26716704
80PDK40.26044417
81PDK30.26044417
82NLK0.25336280
83TBK10.24416511
84LIMK10.23723328
85CDK40.23442663
86PTK60.21383175
87WNK40.21229167
88PRKCQ0.19846648
89RPS6KB10.19785661
90MAP3K40.19033142
91CAMK2G0.18801399
92CASK0.18586318
93PKN10.18388838
94PINK10.18185045
95WNK30.18031055
96MAPKAPK20.17413351
97CDK90.17349169
98RPS6KA60.17337662
99EPHA30.17297309
100RPS6KA10.16180769
101DYRK30.16083188
102ACVR1B0.15224117
103MARK20.15150315
104PRKACG0.14564559
105PAK30.14131225
106PRKD10.13663676
107GRK60.12319743
108NEK20.11669688
109GRK70.11198592
110PRKG10.10899125
111MAPK80.10896487
112STK390.10735162
113CSNK1D0.10305328
114MAP2K20.10059482
115PDK10.09797687
116MAPK110.09785632
117ADRBK10.09623210
118FGFR30.09556866
119NTRK30.09373819
120RPS6KL10.09300757
121RPS6KC10.09300757
122TAOK30.08950960
123MAPK40.08734893
124SGK10.08507445
125CSNK1A10.08236406
126MAP3K50.07819299
127STK110.07728022
128MAPK90.07588499
129STK30.07078824
130SGK2230.05600355
131SYK0.05065874
132YES10.04837351
133CDK11A0.04588740
134IRAK20.03229416
135CSNK1G20.03000660
136CLK10.02861079
137JAK20.02164834
138MAPK130.02091851
139CDK150.02045638
140HCK0.01824250
141MAPK100.01632890
142MARK30.01469613
143CAMK2D0.01460142
144INSR0.01322580
145CDK140.00453889
146RPS6KA30.00073032
147SGK3-0.0265854
148TXK-0.0160347
149JAK1-0.0132742
150CAMK4-0.0115199
151PRKACB-0.0112898
152CDK18-0.0073953
153PLK3-0.0071581
154MAP2K7-0.0020381

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.34977595
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.03661412
3Dilated cardiomyopathy_Homo sapiens_hsa054142.62698071
4Insulin signaling pathway_Homo sapiens_hsa049102.50548662
5FoxO signaling pathway_Homo sapiens_hsa040682.46357179
6Cardiac muscle contraction_Homo sapiens_hsa042602.44300609
7Starch and sucrose metabolism_Homo sapiens_hsa005002.43790196
8Olfactory transduction_Homo sapiens_hsa047402.26969747
9Nitrogen metabolism_Homo sapiens_hsa009102.14922730
10Insulin resistance_Homo sapiens_hsa049312.13265110
11Oxytocin signaling pathway_Homo sapiens_hsa049212.09028960
12Adherens junction_Homo sapiens_hsa045202.08150164
13Glucagon signaling pathway_Homo sapiens_hsa049222.06599649
14Viral myocarditis_Homo sapiens_hsa054162.05745940
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01618422
16Propanoate metabolism_Homo sapiens_hsa006401.99932732
17Chronic myeloid leukemia_Homo sapiens_hsa052201.98558097
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.93175404
19Oxidative phosphorylation_Homo sapiens_hsa001901.91483584
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89505148
21Circadian rhythm_Homo sapiens_hsa047101.72797259
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65341499
23Notch signaling pathway_Homo sapiens_hsa043301.54954520
24Non-small cell lung cancer_Homo sapiens_hsa052231.47470317
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45078768
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44382846
27Acute myeloid leukemia_Homo sapiens_hsa052211.41116733
28Arginine biosynthesis_Homo sapiens_hsa002201.41009003
29AMPK signaling pathway_Homo sapiens_hsa041521.40877966
30Fructose and mannose metabolism_Homo sapiens_hsa000511.36288015
31Renal cell carcinoma_Homo sapiens_hsa052111.35379565
32Type II diabetes mellitus_Homo sapiens_hsa049301.32374477
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29536619
34B cell receptor signaling pathway_Homo sapiens_hsa046621.27102296
35Glioma_Homo sapiens_hsa052141.26765122
36Dorso-ventral axis formation_Homo sapiens_hsa043201.26268511
37Prolactin signaling pathway_Homo sapiens_hsa049171.24984639
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24257537
39Tight junction_Homo sapiens_hsa045301.23928073
40T cell receptor signaling pathway_Homo sapiens_hsa046601.23198654
41Fatty acid degradation_Homo sapiens_hsa000711.21007123
42Butanoate metabolism_Homo sapiens_hsa006501.18887947
43MAPK signaling pathway_Homo sapiens_hsa040101.18033922
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.17152282
45Calcium signaling pathway_Homo sapiens_hsa040201.14667619
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13911308
47Endometrial cancer_Homo sapiens_hsa052131.10390963
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09398818
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09307373
50Hepatitis C_Homo sapiens_hsa051601.07480749
51Insulin secretion_Homo sapiens_hsa049111.07120476
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.06412333
53Pyruvate metabolism_Homo sapiens_hsa006201.06018625
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04921707
55Linoleic acid metabolism_Homo sapiens_hsa005911.03159218
56Renin secretion_Homo sapiens_hsa049241.02140887
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98734880
58GnRH signaling pathway_Homo sapiens_hsa049120.97422881
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96455163
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96299425
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94679659
62Focal adhesion_Homo sapiens_hsa045100.94605844
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92322755
64Huntingtons disease_Homo sapiens_hsa050160.90558403
65VEGF signaling pathway_Homo sapiens_hsa043700.89723378
66Regulation of autophagy_Homo sapiens_hsa041400.89397513
67Tryptophan metabolism_Homo sapiens_hsa003800.86937062
68Pancreatic cancer_Homo sapiens_hsa052120.86828799
69Galactose metabolism_Homo sapiens_hsa000520.83235029
70Arginine and proline metabolism_Homo sapiens_hsa003300.81695105
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81368232
72Circadian entrainment_Homo sapiens_hsa047130.78650894
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.78216489
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78076346
75Sulfur relay system_Homo sapiens_hsa041220.77622725
76Alzheimers disease_Homo sapiens_hsa050100.77133706
77ErbB signaling pathway_Homo sapiens_hsa040120.76265328
78Proteoglycans in cancer_Homo sapiens_hsa052050.74306208
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71939590
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.71422490
81Carbon metabolism_Homo sapiens_hsa012000.71035403
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70968866
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69920990
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.69844777
85Phototransduction_Homo sapiens_hsa047440.68878017
86Salivary secretion_Homo sapiens_hsa049700.68770162
87Non-homologous end-joining_Homo sapiens_hsa034500.66548391
88Thyroid cancer_Homo sapiens_hsa052160.65199960
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64191666
90Epstein-Barr virus infection_Homo sapiens_hsa051690.63947472
91Platelet activation_Homo sapiens_hsa046110.63291712
92Peroxisome_Homo sapiens_hsa041460.62883187
93Purine metabolism_Homo sapiens_hsa002300.60552634
94Parkinsons disease_Homo sapiens_hsa050120.60009919
95ABC transporters_Homo sapiens_hsa020100.59962853
96mTOR signaling pathway_Homo sapiens_hsa041500.59777083
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.59510842
98HIF-1 signaling pathway_Homo sapiens_hsa040660.59065846
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58452023
100Viral carcinogenesis_Homo sapiens_hsa052030.58167169
101Long-term depression_Homo sapiens_hsa047300.57684169
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57152636
103Lysine degradation_Homo sapiens_hsa003100.55904585
104beta-Alanine metabolism_Homo sapiens_hsa004100.55894445
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54826169
106Wnt signaling pathway_Homo sapiens_hsa043100.52987834
107Biosynthesis of amino acids_Homo sapiens_hsa012300.52512091
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50801288
109Long-term potentiation_Homo sapiens_hsa047200.50716661
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49665802
111Apoptosis_Homo sapiens_hsa042100.48995360
112Cholinergic synapse_Homo sapiens_hsa047250.48293377
113Gastric acid secretion_Homo sapiens_hsa049710.47995400
114Small cell lung cancer_Homo sapiens_hsa052220.46772056
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46013666
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45523455
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43261303
118Prostate cancer_Homo sapiens_hsa052150.43215705
119Chemokine signaling pathway_Homo sapiens_hsa040620.42614810
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.41183008
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40977499
122Amphetamine addiction_Homo sapiens_hsa050310.40121341
123TNF signaling pathway_Homo sapiens_hsa046680.39394669
124Colorectal cancer_Homo sapiens_hsa052100.38649354
125cAMP signaling pathway_Homo sapiens_hsa040240.37361757
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.37168230
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.35138382
128Fatty acid metabolism_Homo sapiens_hsa012120.34897728
129Systemic lupus erythematosus_Homo sapiens_hsa053220.34156903
130Osteoclast differentiation_Homo sapiens_hsa043800.33453689
131Dopaminergic synapse_Homo sapiens_hsa047280.31934724
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31574885
133Ovarian steroidogenesis_Homo sapiens_hsa049130.30855459
134Phenylalanine metabolism_Homo sapiens_hsa003600.29341397
135Fatty acid biosynthesis_Homo sapiens_hsa000610.28522297
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28507921
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28154782
138Pentose phosphate pathway_Homo sapiens_hsa000300.28003811
139Ether lipid metabolism_Homo sapiens_hsa005650.27362444
140Hepatitis B_Homo sapiens_hsa051610.27263106
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26247430
142Metabolic pathways_Homo sapiens_hsa011000.22789249
143Pancreatic secretion_Homo sapiens_hsa049720.21520425
144Serotonergic synapse_Homo sapiens_hsa047260.18420302
145GABAergic synapse_Homo sapiens_hsa047270.17928580
146PPAR signaling pathway_Homo sapiens_hsa033200.17165167
147Histidine metabolism_Homo sapiens_hsa003400.15191284
148Fatty acid elongation_Homo sapiens_hsa000620.15047747
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14888106

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