MSRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.37520781
2oxidative phosphorylation (GO:0006119)5.05008173
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04647623
4respiratory electron transport chain (GO:0022904)5.02836738
5electron transport chain (GO:0022900)4.96413204
6regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.89035626
7regulation of acyl-CoA biosynthetic process (GO:0050812)4.88013733
8protein complex biogenesis (GO:0070271)4.70022199
9tricarboxylic acid cycle (GO:0006099)4.68635534
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66467349
11ATP synthesis coupled proton transport (GO:0015986)4.66467349
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.58651689
13NADH dehydrogenase complex assembly (GO:0010257)4.58651689
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.58651689
15mitochondrial respiratory chain complex assembly (GO:0033108)4.46938644
16ribosomal small subunit assembly (GO:0000028)4.45165248
17daunorubicin metabolic process (GO:0044597)4.42103313
18polyketide metabolic process (GO:0030638)4.42103313
19doxorubicin metabolic process (GO:0044598)4.42103313
20regulation of cofactor metabolic process (GO:0051193)4.37126687
21regulation of coenzyme metabolic process (GO:0051196)4.37126687
22aerobic respiration (GO:0009060)4.22593379
23inner mitochondrial membrane organization (GO:0007007)4.18158563
24platelet dense granule organization (GO:0060155)4.15980429
25muscle filament sliding (GO:0030049)4.14216573
26actin-myosin filament sliding (GO:0033275)4.14216573
27respiratory chain complex IV assembly (GO:0008535)4.07580498
28sarcoplasmic reticulum calcium ion transport (GO:0070296)3.96373825
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95714566
30branched-chain amino acid catabolic process (GO:0009083)3.94999221
31creatine metabolic process (GO:0006600)3.89539881
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.76525772
33succinate metabolic process (GO:0006105)3.75534235
34DNA deamination (GO:0045006)3.69167118
35oxaloacetate metabolic process (GO:0006107)3.68238238
36regulation of skeletal muscle contraction (GO:0014819)3.67012527
37calcium-mediated signaling using intracellular calcium source (GO:0035584)3.66329476
38regulation of sulfur metabolic process (GO:0042762)3.66296544
39NADH metabolic process (GO:0006734)3.64929109
40branched-chain amino acid metabolic process (GO:0009081)3.64124558
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.63210456
42response to interferon-beta (GO:0035456)3.62804928
43cytochrome complex assembly (GO:0017004)3.55698362
44regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.53092850
45definitive hemopoiesis (GO:0060216)3.52743208
46metallo-sulfur cluster assembly (GO:0031163)3.49116973
47iron-sulfur cluster assembly (GO:0016226)3.49116973
48regulation of oxidative phosphorylation (GO:0002082)3.48717143
49valine metabolic process (GO:0006573)3.47587436
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.44049381
51substrate-independent telencephalic tangential migration (GO:0021826)3.44049381
52regulation of membrane repolarization (GO:0060306)3.43410127
53actin-mediated cell contraction (GO:0070252)3.39864197
54aminoglycoside antibiotic metabolic process (GO:0030647)3.37582965
55phospholipid scrambling (GO:0017121)3.33870527
56positive regulation of respiratory burst (GO:0060267)3.31169660
57proteasome assembly (GO:0043248)3.26641880
58myofibril assembly (GO:0030239)3.24312698
59sarcomere organization (GO:0045214)3.23806659
60ubiquinone biosynthetic process (GO:0006744)3.21979735
61quinone biosynthetic process (GO:1901663)3.21979735
62cardiac myofibril assembly (GO:0055003)3.21142730
63cardiac muscle contraction (GO:0060048)3.18138370
64cellular respiration (GO:0045333)3.17233963
65purine-containing compound salvage (GO:0043101)3.16986629
66fatty acid beta-oxidation (GO:0006635)3.14643429
67dopamine transport (GO:0015872)3.14221202
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10131961
69purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07959928
70ATP biosynthetic process (GO:0006754)3.07525951
71purine nucleotide salvage (GO:0032261)3.05796562
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05724425
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04983218
742-oxoglutarate metabolic process (GO:0006103)3.04663307
75mannosylation (GO:0097502)3.02931199
76L-methionine salvage (GO:0071267)3.00895107
77L-methionine biosynthetic process (GO:0071265)3.00895107
78amino acid salvage (GO:0043102)3.00895107
79regulation of cellular respiration (GO:0043457)3.00749494
80negative regulation of erythrocyte differentiation (GO:0045647)3.00524150
81oxygen transport (GO:0015671)3.00233998
82regulation of relaxation of muscle (GO:1901077)2.99817117
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97976579
84fatty acid catabolic process (GO:0009062)2.97922827
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97003274
86establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95548822
87mitochondrion transport along microtubule (GO:0047497)2.95548822
88negative regulation of calcium ion transmembrane transport (GO:1903170)2.95458931
89negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.95458931
90establishment of mitochondrion localization (GO:0051654)2.93773578
91pyrimidine nucleobase catabolic process (GO:0006208)2.91973558
92GDP-mannose metabolic process (GO:0019673)2.90665999
93short-term memory (GO:0007614)2.90636037
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89679405
95L-phenylalanine catabolic process (GO:0006559)2.89679405
96heart contraction (GO:0060047)2.89232098
97heart process (GO:0003015)2.89232098
98mast cell activation (GO:0045576)2.88778702
99lysine metabolic process (GO:0006553)2.88155984
100lysine catabolic process (GO:0006554)2.88155984
101cellular ketone body metabolic process (GO:0046950)2.86805273
102termination of RNA polymerase III transcription (GO:0006386)2.85789368
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.85789368
104striated muscle contraction (GO:0006941)2.85771518
105L-phenylalanine metabolic process (GO:0006558)2.84144630
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84144630
107response to misfolded protein (GO:0051788)2.83370719
108glyoxylate metabolic process (GO:0046487)2.83115246
109neuronal action potential propagation (GO:0019227)2.82924780
110regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.82599564
111mast cell degranulation (GO:0043303)2.80943116
112mast cell activation involved in immune response (GO:0002279)2.80943116
113neuronal ion channel clustering (GO:0045161)2.78171682
114pattern specification involved in kidney development (GO:0061004)2.77665074
115translational termination (GO:0006415)2.76087901
116lipid oxidation (GO:0034440)2.75145369
117fatty acid oxidation (GO:0019395)2.74526269
118negative regulation of response to food (GO:0032096)2.69934509
119negative regulation of appetite (GO:0032099)2.69934509
120AMP metabolic process (GO:0046033)2.69168243
121ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68671776
122adenosine metabolic process (GO:0046085)2.67552939
123axonal fasciculation (GO:0007413)2.65934990
124viral transcription (GO:0019083)2.65889981
125aspartate family amino acid catabolic process (GO:0009068)2.65822215
126respiratory system process (GO:0003016)2.65358139
127pseudouridine synthesis (GO:0001522)2.64475986
128arginine catabolic process (GO:0006527)2.64281247
129segment specification (GO:0007379)2.63857037
130ubiquinone metabolic process (GO:0006743)2.62769138
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62463879
132regulation of cell communication by electrical coupling (GO:0010649)2.60984311
133ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.60267666
134GTP biosynthetic process (GO:0006183)2.60173905
135quinone metabolic process (GO:1901661)2.59140376
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.59139990
137tricarboxylic acid metabolic process (GO:0072350)2.57754508
138regulation of mitochondrial translation (GO:0070129)2.57239928
139membrane repolarization (GO:0086009)2.57157819
140somite development (GO:0061053)2.55301712
141catecholamine transport (GO:0051937)2.54671254
142chaperone-mediated protein transport (GO:0072321)2.53271836
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51820912
144ribosomal small subunit biogenesis (GO:0042274)2.51265785
145purine nucleoside monophosphate biosynthetic process (GO:0009127)2.50995867
146purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.50995867
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50889708
148behavioral response to nicotine (GO:0035095)2.50451739
149regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.48217144
150nucleoside triphosphate biosynthetic process (GO:0009142)2.47187941
151monocarboxylic acid catabolic process (GO:0072329)2.46900322
152negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46884939
153skeletal muscle contraction (GO:0003009)2.46836640
154adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.46599543
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46202547
156positive regulation of sodium ion transmembrane transport (GO:1902307)2.44766906
157negative regulation of cation channel activity (GO:2001258)2.43579072
158nucleobase catabolic process (GO:0046113)2.40674779
159positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.40450983
160cell communication by electrical coupling (GO:0010644)2.40362191
161neuron recognition (GO:0008038)2.38969560
162fatty acid transmembrane transport (GO:1902001)2.38498110
163response to inactivity (GO:0014854)2.37626058
164postsynaptic membrane organization (GO:0001941)2.35952053
165negative regulation of potassium ion transmembrane transport (GO:1901380)2.35647363
166detection of calcium ion (GO:0005513)2.35049268
167membrane depolarization during action potential (GO:0086010)2.33839935
168regulation of synapse structural plasticity (GO:0051823)2.33287166
169response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.32744418
170regulation of sequestering of triglyceride (GO:0010889)2.31529129
171brown fat cell differentiation (GO:0050873)2.31493406
172response to muscle activity (GO:0014850)2.31215005
173potassium ion export (GO:0071435)2.30214758
174positive regulation of sodium ion transport (GO:0010765)2.28202899
175actin filament-based movement (GO:0030048)2.25512872
176regulation of potassium ion transmembrane transporter activity (GO:1901016)2.25019344
177skeletal muscle fiber development (GO:0048741)2.24015275
178regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.23921689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50403492
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.75050811
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67615368
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56386149
5SRF_21415370_ChIP-Seq_HL-1_Mouse3.37074147
6SCL_19346495_ChIP-Seq_HPC-7_Human3.23383989
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14871015
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.09141862
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05621521
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99466801
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93633049
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83333807
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.78274689
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69241363
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.65057747
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.63475305
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61890400
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.55087003
19GATA1_22025678_ChIP-Seq_K562_Human2.52755316
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.50361819
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47751998
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.42673672
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.42435286
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40766709
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35290023
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32990622
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28326551
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.26043676
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21862298
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.16180792
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14989426
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.13185301
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11438513
34CTCF_27219007_Chip-Seq_Bcells_Human2.08499761
35JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07934170
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03359561
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02080138
38EZH2_27304074_Chip-Seq_ESCs_Mouse2.00318105
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00121318
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96803183
41LXR_22292898_ChIP-Seq_THP-1_Human1.96745639
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96687443
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.96183602
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94570115
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94250726
46FOXP3_21729870_ChIP-Seq_TREG_Human1.94249917
47VDR_23849224_ChIP-Seq_CD4+_Human1.93061687
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86892420
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85039801
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83480981
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.83222703
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82852099
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82686313
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81442383
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80988957
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.80205093
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77706540
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77706540
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77266344
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76159010
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.75986097
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73272331
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.73043879
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.72827057
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71620065
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.69879314
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69343689
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69141934
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68706102
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67596944
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.67571678
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.67205210
73REST_21632747_ChIP-Seq_MESCs_Mouse1.62102700
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60892753
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.60696783
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57088802
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56424540
78DROSHA_22980978_ChIP-Seq_HELA_Human1.56293798
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55251036
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55210716
81* REST_18959480_ChIP-ChIP_MESCs_Mouse1.53026191
82TAF15_26573619_Chip-Seq_HEK293_Human1.52462555
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51563130
84P68_20966046_ChIP-Seq_HELA_Human1.51210820
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49688575
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49402566
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46592442
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43813206
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43726195
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40299020
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40171899
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38616743
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.36143289
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.35726240
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33971123
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33088636
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31346721
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31077796
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.29447481
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29230612
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.28738547
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.28136178
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27586935
104GABP_19822575_ChIP-Seq_HepG2_Human1.26411077
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26369079
106SA1_27219007_Chip-Seq_Bcells_Human1.25065364
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20224397
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19422390
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19199890
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18760482
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18290121
112SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17762321
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16770651
114MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16513569
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16442681
116AR_20517297_ChIP-Seq_VCAP_Human1.15777124
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.15713246
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15393196
119CTCF_20526341_ChIP-Seq_ESCs_Human1.14450627
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14323859
121VDR_21846776_ChIP-Seq_THP-1_Human1.13476934
122RARB_27405468_Chip-Seq_BRAIN_Mouse1.12256919
123E2F1_20622854_ChIP-Seq_HELA_Human1.10317162
124KDM2B_26808549_Chip-Seq_K562_Human1.10127553
125RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09714107
126SPI1_23547873_ChIP-Seq_NB4_Human1.09111705
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08488927
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07907679
129SMC4_20622854_ChIP-Seq_HELA_Human1.07205809
130IRF1_19129219_ChIP-ChIP_H3396_Human1.06834288
131GBX2_23144817_ChIP-Seq_PC3_Human1.06801734
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05826874
133OCT4_19829295_ChIP-Seq_ESCs_Human1.02516584
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01377177
135BCOR_27268052_Chip-Seq_Bcells_Human1.01000196
136MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00715015
137PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00595333
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00344594
139ERA_21632823_ChIP-Seq_H3396_Human0.99785016
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99773777
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99371904
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.99010487
143* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98923748
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98716849
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.98462531
146GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98069276
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97478804
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.96646318
149STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96396944
150* CTCF_26484167_Chip-Seq_Bcells_Mouse0.95940473
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95646777
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95482091
153XRN2_22483619_ChIP-Seq_HELA_Human0.94911897
154PHF8_20622854_ChIP-Seq_HELA_Human0.94049992
155* TAF2_19829295_ChIP-Seq_ESCs_Human0.94039690
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93628090
157ZNF263_19887448_ChIP-Seq_K562_Human0.93529080
158FOXP1_21924763_ChIP-Seq_HESCs_Human0.92567910
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91999645
160NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91315197
161IGF1R_20145208_ChIP-Seq_DFB_Human0.90669845
162* NANOG_20526341_ChIP-Seq_ESCs_Human0.90634017
163CTCF_21964334_Chip-Seq_Bcells_Human0.90341666
164* MYC_27129775_Chip-Seq_CORNEA_Mouse0.89769158
165POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89698994
166TP63_22573176_ChIP-Seq_HFKS_Human0.89182109
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88700175
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88243212
169TTF2_22483619_ChIP-Seq_HELA_Human0.87956111
170ERG_20517297_ChIP-Seq_VCAP_Human0.87832150
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87483616
172ELK1_19687146_ChIP-ChIP_HELA_Human0.87439945
173EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87161139
174DCP1A_22483619_ChIP-Seq_HELA_Human0.85363864
175CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84773839
176STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84647700
177CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84468766
178RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84263647
179STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84212496
180SOX2_21211035_ChIP-Seq_LN229_Human0.83470197
181* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81488013
182FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81339669
183* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80791444
184PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78726672
185RUNX_20019798_ChIP-Seq_JUKART_Human0.78167355
186CIITA_25753668_ChIP-Seq_RAJI_Human0.76697971
187BCL6_27268052_Chip-Seq_Bcells_Human0.75323279
188TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75060678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.65439351
2MP0004147_increased_porphyrin_level3.61827895
3MP0009379_abnormal_foot_pigmentation3.35020911
4MP0003806_abnormal_nucleotide_metabolis3.04360960
5MP0006036_abnormal_mitochondrial_physio3.03560459
6MP0004084_abnormal_cardiac_muscle2.83517374
7MP0002653_abnormal_ependyma_morphology2.73490057
8MP0003646_muscle_fatigue2.65288650
9MP0003787_abnormal_imprinting2.59162505
10MP0004036_abnormal_muscle_relaxation2.40639617
11MP0000749_muscle_degeneration2.35146197
12MP0001986_abnormal_taste_sensitivity2.34889500
13MP0004215_abnormal_myocardial_fiber2.33949369
14MP0009697_abnormal_copulation2.33752398
15MP0000751_myopathy2.28852967
16MP0003122_maternal_imprinting2.14480952
17MP0003123_paternal_imprinting2.13376838
18MP0002822_catalepsy2.03684862
19MP0003879_abnormal_hair_cell1.99529534
20MP0001188_hyperpigmentation1.99410475
21MP0005330_cardiomyopathy1.98777362
22MP0006035_abnormal_mitochondrial_morpho1.92561261
23MP0005085_abnormal_gallbladder_physiolo1.88678244
24MP0000750_abnormal_muscle_regeneration1.88281286
25MP0004859_abnormal_synaptic_plasticity1.88173897
26MP0003186_abnormal_redox_activity1.87913086
27MP0003656_abnormal_erythrocyte_physiolo1.87378900
28MP0002396_abnormal_hematopoietic_system1.86195172
29MP0005423_abnormal_somatic_nervous1.72049938
30MP0004130_abnormal_muscle_cell1.71481915
31MP0004484_altered_response_of1.70348682
32MP0001764_abnormal_homeostasis1.67712740
33MP0005075_abnormal_melanosome_morpholog1.64082777
34MP0004808_abnormal_hematopoietic_stem1.56635333
35MP0008875_abnormal_xenobiotic_pharmacok1.56021860
36MP0004510_myositis1.54856474
37MP0005365_abnormal_bile_salt1.53173901
38MP0000778_abnormal_nervous_system1.49292063
39MP0002736_abnormal_nociception_after1.47067630
40MP0002009_preneoplasia1.46548057
41MP0003724_increased_susceptibility_to1.45682322
42MP0003191_abnormal_cellular_cholesterol1.42546460
43MP0004145_abnormal_muscle_electrophysio1.40564371
44MP0002972_abnormal_cardiac_muscle1.35569370
45MP0001544_abnormal_cardiovascular_syste1.33437752
46MP0005385_cardiovascular_system_phenoty1.33437752
47MP0000372_irregular_coat_pigmentation1.32022792
48MP0003121_genomic_imprinting1.31043830
49MP0003635_abnormal_synaptic_transmissio1.29739360
50MP0005409_darkened_coat_color1.28769072
51MP0005397_hematopoietic_system_phenotyp1.28699538
52MP0001545_abnormal_hematopoietic_system1.28699538
53MP0003011_delayed_dark_adaptation1.28469341
54MP0004085_abnormal_heartbeat1.27108108
55MP0001485_abnormal_pinna_reflex1.26517158
56MP0001905_abnormal_dopamine_level1.25384847
57MP0000759_abnormal_skeletal_muscle1.24376549
58MP0005646_abnormal_pituitary_gland1.23312775
59MP0001968_abnormal_touch/_nociception1.23282888
60MP0003828_pulmonary_edema1.20482553
61MP0002735_abnormal_chemical_nociception1.19862950
62MP0008775_abnormal_heart_ventricle1.19465996
63MP0002234_abnormal_pharynx_morphology1.18030045
64MP0000230_abnormal_systemic_arterial1.17859899
65MP0000747_muscle_weakness1.17325852
66MP0006276_abnormal_autonomic_nervous1.17279277
67MP0005671_abnormal_response_to1.17046660
68MP0005332_abnormal_amino_acid1.17012136
69MP0005165_increased_susceptibility_to1.15815515
70MP0001853_heart_inflammation1.15031043
71MP0001440_abnormal_grooming_behavior1.15012012
72MP0002733_abnormal_thermal_nociception1.14755983
73MP0009840_abnormal_foam_cell1.13903566
74MP0005620_abnormal_muscle_contractility1.13175131
75MP0005319_abnormal_enzyme/_coenzyme1.13085120
76MP0004858_abnormal_nervous_system1.12780282
77MP0002063_abnormal_learning/memory/cond1.11256873
78MP0002064_seizures1.11017087
79MP0008789_abnormal_olfactory_epithelium1.10817218
80MP0001529_abnormal_vocalization1.10730734
81MP0002572_abnormal_emotion/affect_behav1.09869694
82MP0004142_abnormal_muscle_tone1.09601835
83MP0005666_abnormal_adipose_tissue1.08073585
84MP0005584_abnormal_enzyme/coenzyme_acti1.07990794
85MP0003137_abnormal_impulse_conducting1.07460096
86MP0001970_abnormal_pain_threshold1.06699020
87MP0005084_abnormal_gallbladder_morpholo1.06470363
88MP0005464_abnormal_platelet_physiology1.06108553
89MP0000955_abnormal_spinal_cord1.06072938
90MP0004233_abnormal_muscle_weight1.05450365
91MP0003880_abnormal_central_pattern1.05278929
92MP0005266_abnormal_metabolism1.04960260
93MP0000343_altered_response_to1.03689847
94MP0005636_abnormal_mineral_homeostasis1.01843618
95MP0002971_abnormal_brown_adipose1.01633576
96MP0003195_calcinosis1.01574382
97MP0002876_abnormal_thyroid_physiology1.01266614
98MP0004043_abnormal_pH_regulation1.00378876
99MP0005670_abnormal_white_adipose1.00219551
100MP0010329_abnormal_lipoprotein_level0.99850766
101MP0003221_abnormal_cardiomyocyte_apopto0.98671591
102MP0002734_abnormal_mechanical_nocicepti0.98362264
103MP0002106_abnormal_muscle_physiology0.98176199
104MP0006138_congestive_heart_failure0.98127487
105MP0002166_altered_tumor_susceptibility0.97265837
106MP0000026_abnormal_inner_ear0.96694322
107MP0009785_altered_susceptibility_to0.96278261
108MP0002139_abnormal_hepatobiliary_system0.95299958
109MP0002557_abnormal_social/conspecific_i0.94934567
110MP0003878_abnormal_ear_physiology0.94679299
111MP0005377_hearing/vestibular/ear_phenot0.94679299
112MP0010368_abnormal_lymphatic_system0.94538180
113MP0004185_abnormal_adipocyte_glucose0.94411459
114MP0005645_abnormal_hypothalamus_physiol0.93445044
115MP0003943_abnormal_hepatobiliary_system0.92794970
116MP0005535_abnormal_body_temperature0.90676035
117MP0002132_abnormal_respiratory_system0.89131965
118MP0005394_taste/olfaction_phenotype0.88923363
119MP0005499_abnormal_olfactory_system0.88923363
120MP0002269_muscular_atrophy0.88459072
121MP0004885_abnormal_endolymph0.85114890
122MP0006292_abnormal_olfactory_placode0.85071346
123MP0001486_abnormal_startle_reflex0.84565452
124MP0004270_analgesia0.83837067
125MP0002638_abnormal_pupillary_reflex0.83815882
126MP0009643_abnormal_urine_homeostasis0.82711081
127MP0005375_adipose_tissue_phenotype0.82675227
128MP0002752_abnormal_somatic_nervous0.82524685
129MP0002272_abnormal_nervous_system0.81230083
130MP0002118_abnormal_lipid_homeostasis0.80964695
131MP0005376_homeostasis/metabolism_phenot0.80866789
132MP0005369_muscle_phenotype0.80719176
133MP0002332_abnormal_exercise_endurance0.80505597
134MP0001765_abnormal_ion_homeostasis0.79986224
135MP0002882_abnormal_neuron_morphology0.79982245
136MP0010030_abnormal_orbit_morphology0.79897769
137MP0010630_abnormal_cardiac_muscle0.79534133
138MP0001963_abnormal_hearing_physiology0.79316771
139MP0002184_abnormal_innervation0.77768799
140MP0000049_abnormal_middle_ear0.77679834
141MP0003329_amyloid_beta_deposits0.77112096
142MP0009745_abnormal_behavioral_response0.76951857
143MP0004924_abnormal_behavior0.76949197
144MP0005386_behavior/neurological_phenoty0.76949197
145MP0005058_abnormal_lysosome_morphology0.76853172
146MP0003950_abnormal_plasma_membrane0.76340790
147MP0002067_abnormal_sensory_capabilities0.76088432
148MP0004087_abnormal_muscle_fiber0.75007763
149MP0008874_decreased_physiological_sensi0.73750209
150MP0002095_abnormal_skin_pigmentation0.72544921
151MP0001664_abnormal_digestion0.72378219
152MP0008469_abnormal_protein_level0.71813995
153MP0008872_abnormal_physiological_respon0.71748104

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.27395422
2Abnormal mitochondria in muscle tissue (HP:0008316)5.21540701
3Hepatic necrosis (HP:0002605)5.01580600
4Hepatocellular necrosis (HP:0001404)4.83631078
5Mitochondrial inheritance (HP:0001427)4.81870984
6Acute encephalopathy (HP:0006846)4.72709762
7Increased CSF lactate (HP:0002490)4.41153199
8Myokymia (HP:0002411)4.29026264
9Progressive macrocephaly (HP:0004481)4.28600288
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.92892537
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.92892537
12Lactic acidosis (HP:0003128)3.84103177
13Increased muscle lipid content (HP:0009058)3.80917513
14Muscle fiber inclusion bodies (HP:0100299)3.79859297
15Increased intramyocellular lipid droplets (HP:0012240)3.76519928
16Cerebral edema (HP:0002181)3.74010440
17Type 1 muscle fiber predominance (HP:0003803)3.63509891
18Nemaline bodies (HP:0003798)3.62852787
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.61832119
20Exercise intolerance (HP:0003546)3.60681668
21Polyphagia (HP:0002591)3.59494804
22Asymmetric septal hypertrophy (HP:0001670)3.54716058
23Lipid accumulation in hepatocytes (HP:0006561)3.29820098
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23432099
25Dicarboxylic aciduria (HP:0003215)3.23432099
26Hyporeflexia of lower limbs (HP:0002600)3.22335361
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18684896
28Respiratory failure (HP:0002878)3.16384503
29Myopathic facies (HP:0002058)3.12882418
30Abnormality of the calf musculature (HP:0001430)3.12498300
31Generalized aminoaciduria (HP:0002909)3.11605494
32Increased serum lactate (HP:0002151)3.09918306
333-Methylglutaconic aciduria (HP:0003535)3.03455003
34Increased hepatocellular lipid droplets (HP:0006565)3.02640885
35Syncope (HP:0001279)3.02060681
36Renal Fanconi syndrome (HP:0001994)2.99571464
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98470876
38Muscle fiber splitting (HP:0003555)2.96072149
39Proximal tubulopathy (HP:0000114)2.89479749
40Hyperalaninemia (HP:0003348)2.88327263
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88327263
42Abnormality of alanine metabolism (HP:0010916)2.88327263
43Hypothermia (HP:0002045)2.83935807
44Hypoglycemic coma (HP:0001325)2.83486695
45Abnormality of fatty-acid metabolism (HP:0004359)2.82675998
46Left ventricular hypertrophy (HP:0001712)2.82172107
47Neuroendocrine neoplasm (HP:0100634)2.80768793
48Palpitations (HP:0001962)2.80682522
49Lethargy (HP:0001254)2.78348647
50Myotonia (HP:0002486)2.76060755
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73884740
52Hyperthyroidism (HP:0000836)2.68638950
53EMG: myopathic abnormalities (HP:0003458)2.66569464
54Neoplasm of head and neck (HP:0012288)2.65523972
55Esophageal neoplasm (HP:0100751)2.65523972
56Rimmed vacuoles (HP:0003805)2.65371894
57Ketoacidosis (HP:0001993)2.63925640
58Leukodystrophy (HP:0002415)2.63555681
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.62676467
60Thrombocytosis (HP:0001894)2.61965001
61Pheochromocytoma (HP:0002666)2.60988168
62Abnormal eating behavior (HP:0100738)2.60273608
63Type I transferrin isoform profile (HP:0003642)2.56090797
64Abnormal number of erythroid precursors (HP:0012131)2.51439724
65Prolonged QT interval (HP:0001657)2.50761914
66Oligomenorrhea (HP:0000876)2.49951237
67Optic disc pallor (HP:0000543)2.49888164
68Myoglobinuria (HP:0002913)2.49580635
69Bulbar palsy (HP:0001283)2.49479328
70Abnormality of glycolysis (HP:0004366)2.47497931
71Increased serum pyruvate (HP:0003542)2.47497931
72Increased variability in muscle fiber diameter (HP:0003557)2.47052779
73Ragged-red muscle fibers (HP:0003200)2.45414542
74Abnormality of cells of the erythroid lineage (HP:0012130)2.44352544
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.39915565
76Abnormal EKG (HP:0003115)2.39842988
77Ketosis (HP:0001946)2.39256873
78Abnormality of skeletal muscle fiber size (HP:0012084)2.35437032
79Absent phalangeal crease (HP:0006109)2.32283166
80Double outlet right ventricle (HP:0001719)2.32203110
81Congenital malformation of the right heart (HP:0011723)2.32203110
82Aplastic anemia (HP:0001915)2.32059953
83Waddling gait (HP:0002515)2.31497589
84Distal lower limb muscle weakness (HP:0009053)2.29484272
85Reduced antithrombin III activity (HP:0001976)2.29028847
86Methylmalonic aciduria (HP:0012120)2.27225978
87Methylmalonic acidemia (HP:0002912)2.25366610
88Agitation (HP:0000713)2.24057560
89Lipoatrophy (HP:0100578)2.23810799
90Ventricular arrhythmia (HP:0004308)2.23366901
91Atrial fibrillation (HP:0005110)2.19696554
92Distal arthrogryposis (HP:0005684)2.19669420
93Vomiting (HP:0002013)2.19031727
94Respiratory difficulties (HP:0002880)2.18942726
95Calf muscle hypertrophy (HP:0008981)2.18831497
96Hyperglycinemia (HP:0002154)2.18535333
97Exertional dyspnea (HP:0002875)2.18110266
98Anomalous pulmonary venous return (HP:0010772)2.16258228
99Sudden death (HP:0001699)2.16038825
100Difficulty running (HP:0009046)2.14038618
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13526973
102Abnormal atrioventricular conduction (HP:0005150)2.12842613
103Supraventricular tachycardia (HP:0004755)2.12425557
104Maternal diabetes (HP:0009800)2.11735543
105Ventricular fibrillation (HP:0001663)2.09518081
106Bundle branch block (HP:0011710)2.09420040
107CNS demyelination (HP:0007305)2.09187594
108Fetal akinesia sequence (HP:0001989)2.07427803
109Tinnitus (HP:0000360)2.07180982
110Primary atrial arrhythmia (HP:0001692)2.06781227
111Dilated cardiomyopathy (HP:0001644)2.06663576
112Hyperammonemia (HP:0001987)2.06074164
113Abnormal protein glycosylation (HP:0012346)2.05110053
114Abnormal glycosylation (HP:0012345)2.05110053
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05110053
116Abnormal protein N-linked glycosylation (HP:0012347)2.05110053
117Metabolic acidosis (HP:0001942)2.04679662
118Supraventricular arrhythmia (HP:0005115)2.01350620
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99831923
120EMG: neuropathic changes (HP:0003445)1.98556486
121Rhabdomyolysis (HP:0003201)1.97817972
122Type II lissencephaly (HP:0007260)1.95315097
123Abnormal hemoglobin (HP:0011902)1.95270709
124Glycosuria (HP:0003076)1.93764295
125Abnormality of urine glucose concentration (HP:0011016)1.93764295
126Abnormal pupillary function (HP:0007686)1.93720068
127Muscle hypertrophy of the lower extremities (HP:0008968)1.92847483
128Exercise-induced muscle cramps (HP:0003710)1.89335268
129Exercise-induced myalgia (HP:0003738)1.89028786
130Emotional lability (HP:0000712)1.88095840
131Gowers sign (HP:0003391)1.88032797
132Heart block (HP:0012722)1.87831069
133Infantile muscular hypotonia (HP:0008947)1.86737135
134Neck muscle weakness (HP:0000467)1.86563558
135Cerebral palsy (HP:0100021)1.86179868
136Ventricular tachycardia (HP:0004756)1.85363416
137Inability to walk (HP:0002540)1.85305783
138Delayed CNS myelination (HP:0002188)1.81692402
139Abnormality of the pulmonary veins (HP:0011718)1.81218775
140Type 2 muscle fiber atrophy (HP:0003554)1.81095991
141Microvesicular hepatic steatosis (HP:0001414)1.81060965
142Muscle stiffness (HP:0003552)1.80479735
143Opisthotonus (HP:0002179)1.79536007
144Prolonged neonatal jaundice (HP:0006579)1.79073242
145Abnormality of renal resorption (HP:0011038)1.78254153
146Petechiae (HP:0000967)1.77445198
147Nausea (HP:0002018)1.76889700
148Nonprogressive disorder (HP:0003680)1.76628885
149Gliosis (HP:0002171)1.75635778
150Gait imbalance (HP:0002141)1.75522364
151Visual hallucinations (HP:0002367)1.74607611
152Failure to thrive in infancy (HP:0001531)1.73983317
153Systemic lupus erythematosus (HP:0002725)1.71471721
154Poor suck (HP:0002033)1.68053981
155Abnormality of the left ventricular outflow tract (HP:0011103)1.66425402
156Subaortic stenosis (HP:0001682)1.66425402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.03202987
2BCKDK3.49054214
3MUSK3.26271648
4STK163.25205139
5MYLK2.91125842
6NME22.84341799
7PIK3CG2.75191878
8FLT32.60106622
9KIT2.47039112
10TIE12.20775139
11MARK12.12430131
12CDK192.08090262
13PINK12.04637595
14ABL21.92661020
15GRK71.89754111
16KDR1.88970326
17EPHB21.80848721
18PDK21.79459860
19SIK31.79072041
20LIMK11.77882776
21DMPK1.72274413
22ARAF1.70833841
23INSRR1.69595258
24PIM21.66530220
25CASK1.66483336
26MAP2K31.59444548
27DYRK1B1.57233870
28MAP3K91.55786303
29VRK11.51594154
30ADRBK21.51312025
31MARK21.49108619
32MAP2K71.46912692
33DYRK21.46095571
34NTRK31.43068756
35DAPK11.39610640
36TNIK1.39041417
37TEC1.38172451
38PAK31.36769863
39TESK11.36122926
40TXK1.35349349
41PRKD31.35258632
42PDK31.31700854
43PDK41.31700854
44ERN11.28234492
45MAPK151.28222263
46MAPKAPK51.22811549
47CCNB11.21761164
48EPHA41.19923307
49TGFBR21.18174667
50MATK1.16823214
51PRKD21.16565311
52MAPKAPK31.15112829
53TGFBR11.14625021
54VRK21.14452497
55MAP4K11.12927957
56GRK51.10201120
57BTK1.09422149
58MAPK131.09407181
59WEE11.05949083
60PRKG21.04640803
61TSSK61.04596184
62MAP2K61.02185880
63CSF1R0.97277800
64RIPK40.97025503
65NLK0.94774770
66TESK20.94278438
67PKN10.91630176
68PHKG20.91529518
69PHKG10.91529518
70RPS6KA20.91096677
71CAMK10.89550619
72SYK0.88431628
73CDK80.86534681
74ZAP700.86219987
75PRKCG0.84503457
76DYRK30.84171405
77MAPK120.83518867
78PIK3CA0.82417939
79PRKD10.81865211
80NME10.80561066
81NTRK20.80204672
82STK110.79927468
83MAP2K40.79347883
84LMTK20.77330152
85DDR20.73610926
86MAP3K110.73492647
87IRAK40.72515735
88GRK10.71566520
89MAPK70.70378136
90LRRK20.70117683
91OBSCN0.70113572
92BRAF0.69436014
93JAK30.69164959
94TNK20.68752043
95TRIB30.68539606
96CAMKK20.67556920
97TTN0.67543948
98PRKCH0.67084306
99CAMK2B0.66515856
100STK240.63127971
101PRKCZ0.62219626
102CDK50.62054458
103PAK60.61901985
104CSNK1G20.60530654
105PRKAA10.59962462
106MAPK40.58638451
107TAOK10.57425527
108ILK0.56774529
109MAP3K70.56036183
110CAMK40.54337673
111RPS6KL10.53711358
112RPS6KC10.53711358
113SGK2230.53652401
114SGK4940.53652401
115MOS0.53644627
116DYRK1A0.53061199
117ICK0.52915985
118MINK10.52398798
119CAMKK10.51854010
120DAPK20.50736187
121CAMK2D0.50584178
122CSNK1G30.50025883
123MKNK20.49730579
124PTK2B0.48822881
125PRKCD0.48173615
126PDPK10.47702813
127TBK10.47624910
128RPS6KA60.47523589
129LCK0.46900618
130MAP3K60.46643949
131PKN20.45389222
132ADRBK10.45007797
133ROCK10.44058059
134PRKCE0.42628012
135PRKCA0.42071388
136RAF10.41983247
137MKNK10.41642550
138DAPK30.41088186
139CAMK2A0.40901334
140TRPM70.40357481
141LYN0.39464085
142FES0.39337852
143CAMK2G0.39143211
144BMPR1B0.38351762
145PRKAA20.37021368
146WNK30.36866767
147PRKACA0.36656892
148IKBKE0.33675612
149MAPK110.31440881
150YES10.30494967
151TYK20.30191001

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.32771799
2Oxidative phosphorylation_Homo sapiens_hsa001904.22057822
3Parkinsons disease_Homo sapiens_hsa050123.95178161
4Propanoate metabolism_Homo sapiens_hsa006403.11969630
5Ribosome_Homo sapiens_hsa030102.89143978
6Alzheimers disease_Homo sapiens_hsa050102.83624456
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69834413
8Huntingtons disease_Homo sapiens_hsa050162.56262522
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48863108
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35249325
11Pyruvate metabolism_Homo sapiens_hsa006202.35248568
12Fatty acid elongation_Homo sapiens_hsa000622.32227095
13Fatty acid degradation_Homo sapiens_hsa000712.21465606
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20056332
15Proteasome_Homo sapiens_hsa030502.19333405
16Folate biosynthesis_Homo sapiens_hsa007902.17197524
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94862918
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92841755
19Cardiac muscle contraction_Homo sapiens_hsa042601.92310099
20Carbon metabolism_Homo sapiens_hsa012001.81712673
21Peroxisome_Homo sapiens_hsa041461.74814544
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72278528
23Fatty acid metabolism_Homo sapiens_hsa012121.55156937
24Protein export_Homo sapiens_hsa030601.52460986
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52176782
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51736091
27RNA polymerase_Homo sapiens_hsa030201.50763474
28Synaptic vesicle cycle_Homo sapiens_hsa047211.37630567
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34655167
30DNA replication_Homo sapiens_hsa030301.32145472
31Butanoate metabolism_Homo sapiens_hsa006501.31632485
32Sulfur relay system_Homo sapiens_hsa041221.25623633
33Pyrimidine metabolism_Homo sapiens_hsa002401.24561017
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.22705590
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22618104
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21995339
37Fructose and mannose metabolism_Homo sapiens_hsa000511.16591682
38Insulin secretion_Homo sapiens_hsa049111.15247346
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.09728735
40Linoleic acid metabolism_Homo sapiens_hsa005911.08271084
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07743428
42Metabolic pathways_Homo sapiens_hsa011000.99052506
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98614424
44Mismatch repair_Homo sapiens_hsa034300.97953905
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95516873
46Purine metabolism_Homo sapiens_hsa002300.92520519
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89856961
48Cocaine addiction_Homo sapiens_hsa050300.88698309
49Retinol metabolism_Homo sapiens_hsa008300.88007888
50Biosynthesis of amino acids_Homo sapiens_hsa012300.87501354
51Nicotine addiction_Homo sapiens_hsa050330.86958984
52Fat digestion and absorption_Homo sapiens_hsa049750.84752440
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83065650
54Tyrosine metabolism_Homo sapiens_hsa003500.82443841
55Oxytocin signaling pathway_Homo sapiens_hsa049210.82428464
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81660965
57Tryptophan metabolism_Homo sapiens_hsa003800.80814925
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80367018
59beta-Alanine metabolism_Homo sapiens_hsa004100.79126889
60PPAR signaling pathway_Homo sapiens_hsa033200.77487536
61Caffeine metabolism_Homo sapiens_hsa002320.76181400
62Phenylalanine metabolism_Homo sapiens_hsa003600.74811803
63Dopaminergic synapse_Homo sapiens_hsa047280.74670713
64Morphine addiction_Homo sapiens_hsa050320.71787722
65Glutathione metabolism_Homo sapiens_hsa004800.70428728
66Gastric acid secretion_Homo sapiens_hsa049710.69678796
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69597358
68Chemical carcinogenesis_Homo sapiens_hsa052040.69496441
69GABAergic synapse_Homo sapiens_hsa047270.68238970
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67349954
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64093100
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.63932715
73Renin secretion_Homo sapiens_hsa049240.63693560
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63088270
75Sulfur metabolism_Homo sapiens_hsa009200.62556392
76Axon guidance_Homo sapiens_hsa043600.61938064
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61367773
78Pentose phosphate pathway_Homo sapiens_hsa000300.60765542
79Ovarian steroidogenesis_Homo sapiens_hsa049130.60138217
80Galactose metabolism_Homo sapiens_hsa000520.59722957
81Glutamatergic synapse_Homo sapiens_hsa047240.59614993
82Other glycan degradation_Homo sapiens_hsa005110.59173990
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56703054
84Starch and sucrose metabolism_Homo sapiens_hsa005000.56111884
85AMPK signaling pathway_Homo sapiens_hsa041520.55995627
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.55711482
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53947417
88Serotonergic synapse_Homo sapiens_hsa047260.53320206
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53224450
90Phototransduction_Homo sapiens_hsa047440.52407979
91Histidine metabolism_Homo sapiens_hsa003400.52403875
92Arginine and proline metabolism_Homo sapiens_hsa003300.51955553
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.50927879
94Lysosome_Homo sapiens_hsa041420.50730421
95Calcium signaling pathway_Homo sapiens_hsa040200.50674043
96Vitamin B6 metabolism_Homo sapiens_hsa007500.49494364
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49464330
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48984204
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.47392790
100Cholinergic synapse_Homo sapiens_hsa047250.46446683
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46332553
102Taste transduction_Homo sapiens_hsa047420.45907219
103Regulation of autophagy_Homo sapiens_hsa041400.44713875
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.44546071
105Arachidonic acid metabolism_Homo sapiens_hsa005900.36703114
106Collecting duct acid secretion_Homo sapiens_hsa049660.36086180
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35220371
108Arginine biosynthesis_Homo sapiens_hsa002200.33999195
109Olfactory transduction_Homo sapiens_hsa047400.32040115
110N-Glycan biosynthesis_Homo sapiens_hsa005100.29722917
111Vitamin digestion and absorption_Homo sapiens_hsa049770.29158814
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27919307
113RNA degradation_Homo sapiens_hsa030180.26442324
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26344080
115Glycerolipid metabolism_Homo sapiens_hsa005610.26117772
116Nucleotide excision repair_Homo sapiens_hsa034200.25938218
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24087852
118Complement and coagulation cascades_Homo sapiens_hsa046100.22274232
119Non-homologous end-joining_Homo sapiens_hsa034500.21810888
120Circadian entrainment_Homo sapiens_hsa047130.20632174
121Glucagon signaling pathway_Homo sapiens_hsa049220.20297220
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17885048
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.17808186
124ABC transporters_Homo sapiens_hsa020100.17565343
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.16472218
126Dilated cardiomyopathy_Homo sapiens_hsa054140.15828378
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.15071098
128Primary immunodeficiency_Homo sapiens_hsa053400.13539057
129Salivary secretion_Homo sapiens_hsa049700.12987770
130Bile secretion_Homo sapiens_hsa049760.12714552
131Sphingolipid metabolism_Homo sapiens_hsa006000.12601166
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11813855
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10674317

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