MSRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.74003246
2L-phenylalanine catabolic process (GO:0006559)6.74003246
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.54765820
4L-phenylalanine metabolic process (GO:0006558)6.50526315
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.50526315
6negative regulation of cell killing (GO:0031342)6.36318944
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.36318944
8positive regulation by symbiont of host defense response (GO:0052509)6.12221415
9modulation by symbiont of host defense response (GO:0052031)6.12221415
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.12221415
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.12221415
12positive regulation by organism of defense response of other organism involved in symbiotic interact6.12221415
13modulation by symbiont of host immune response (GO:0052553)6.12221415
14aromatic amino acid family catabolic process (GO:0009074)6.11391387
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.88264118
16neutrophil activation involved in immune response (GO:0002283)5.81479365
17detection of other organism (GO:0098543)5.77947821
18antigen processing and presentation of endogenous antigen (GO:0019883)5.73267604
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.69785712
20detection of bacterium (GO:0016045)5.64926626
21leukocyte migration involved in inflammatory response (GO:0002523)5.57558394
22tryptophan catabolic process (GO:0006569)5.56713214
23indole-containing compound catabolic process (GO:0042436)5.56713214
24indolalkylamine catabolic process (GO:0046218)5.56713214
25kynurenine metabolic process (GO:0070189)5.51933830
26glyoxylate metabolic process (GO:0046487)5.39498647
27bile acid biosynthetic process (GO:0006699)5.29163522
28alpha-linolenic acid metabolic process (GO:0036109)5.28808192
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.28073822
30tryptophan metabolic process (GO:0006568)5.23703748
31leukocyte aggregation (GO:0070486)5.18257426
32urea metabolic process (GO:0019627)5.16204991
33urea cycle (GO:0000050)5.16204991
34positive regulation of gamma-delta T cell activation (GO:0046645)5.15051125
35complement activation, alternative pathway (GO:0006957)5.08376155
36sulfur amino acid catabolic process (GO:0000098)5.08076844
37protein carboxylation (GO:0018214)5.07024355
38peptidyl-glutamic acid carboxylation (GO:0017187)5.07024355
39negative regulation of fibrinolysis (GO:0051918)5.00567745
40cysteine metabolic process (GO:0006534)4.98669992
41detection of external biotic stimulus (GO:0098581)4.98356933
42response to peptidoglycan (GO:0032494)4.96099556
43high-density lipoprotein particle remodeling (GO:0034375)4.95166671
44macrophage activation involved in immune response (GO:0002281)4.94581318
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91230804
46nitrogen cycle metabolic process (GO:0071941)4.76727679
47regulation of protein activation cascade (GO:2000257)4.76704135
48regulation of fibrinolysis (GO:0051917)4.71328451
49detection of molecule of bacterial origin (GO:0032490)4.68883459
50regulation of triglyceride catabolic process (GO:0010896)4.68658139
51respiratory burst (GO:0045730)4.62214156
52serine family amino acid catabolic process (GO:0009071)4.58359952
53lysine catabolic process (GO:0006554)4.53436337
54lysine metabolic process (GO:0006553)4.53436337
55neutrophil activation (GO:0042119)4.51612442
56regulation of complement activation (GO:0030449)4.49310280
57bile acid metabolic process (GO:0008206)4.48251467
58regulation of B cell receptor signaling pathway (GO:0050855)4.47574350
59negative regulation of lymphocyte mediated immunity (GO:0002707)4.43301206
60aromatic amino acid family metabolic process (GO:0009072)4.40171313
61homocysteine metabolic process (GO:0050667)4.36636123
62reverse cholesterol transport (GO:0043691)4.32427602
63amino-acid betaine metabolic process (GO:0006577)4.32401987
64cellular extravasation (GO:0045123)4.32383722
65detection of biotic stimulus (GO:0009595)4.31227259
66protein-lipid complex remodeling (GO:0034368)4.30280279
67macromolecular complex remodeling (GO:0034367)4.30280279
68plasma lipoprotein particle remodeling (GO:0034369)4.30280279
69regulation of cholesterol esterification (GO:0010872)4.29942285
70plasma lipoprotein particle clearance (GO:0034381)4.29273261
71regulation of interferon-beta biosynthetic process (GO:0045357)4.27718576
72response to host immune response (GO:0052572)4.26524074
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.26524074
74phospholipid efflux (GO:0033700)4.21947191
75negative regulation of interleukin-12 production (GO:0032695)4.20332660
76alpha-amino acid catabolic process (GO:1901606)4.19119617
77tyrosine metabolic process (GO:0006570)4.17564832
78immunoglobulin mediated immune response (GO:0016064)4.16560949
79triglyceride homeostasis (GO:0070328)4.12914297
80acylglycerol homeostasis (GO:0055090)4.12914297
81response to interleukin-15 (GO:0070672)4.10730136
82cellular ketone body metabolic process (GO:0046950)4.10081504
83negative regulation of sterol transport (GO:0032372)4.08456975
84negative regulation of cholesterol transport (GO:0032375)4.08456975
85coenzyme catabolic process (GO:0009109)4.07535051
86granulocyte activation (GO:0036230)4.04621702
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.99518858
88ethanol oxidation (GO:0006069)3.95390721
89aldehyde catabolic process (GO:0046185)3.95242247
90negative regulation of leukocyte mediated immunity (GO:0002704)3.92333331
91response to host (GO:0075136)3.91643819
92response to host defenses (GO:0052200)3.91643819
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91643819
94cellular amino acid catabolic process (GO:0009063)3.90234804
95indolalkylamine metabolic process (GO:0006586)3.87787289
96cellular modified amino acid catabolic process (GO:0042219)3.86570107
97imidazole-containing compound metabolic process (GO:0052803)3.86185800
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84732490
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.84046629
100cellular glucuronidation (GO:0052695)3.83861749
101microglial cell activation (GO:0001774)3.83617196
102glycine metabolic process (GO:0006544)3.81695662
103bile acid and bile salt transport (GO:0015721)3.81660160
104amine catabolic process (GO:0009310)3.80789769
105cellular biogenic amine catabolic process (GO:0042402)3.80789769
106neutrophil mediated immunity (GO:0002446)3.79807745
107regulation of mast cell degranulation (GO:0043304)3.78638112
108cholesterol efflux (GO:0033344)3.78609231
109negative regulation of phagocytosis (GO:0050765)3.77081336
110benzene-containing compound metabolic process (GO:0042537)3.75396125
111glutamate metabolic process (GO:0006536)3.74030117
112serine family amino acid metabolic process (GO:0009069)3.73488612
113phospholipid homeostasis (GO:0055091)3.72638775
114production of molecular mediator involved in inflammatory response (GO:0002532)3.72165604
115myeloid cell activation involved in immune response (GO:0002275)3.71840107
116positive regulation of lipid catabolic process (GO:0050996)3.71333590
117cellular response to interleukin-15 (GO:0071350)3.71254238
118fibrinolysis (GO:0042730)3.68230075
119dicarboxylic acid biosynthetic process (GO:0043650)3.67967520
120acetyl-CoA metabolic process (GO:0006084)3.65396932
121positive regulation of lipoprotein lipase activity (GO:0051006)3.64821433
122positive regulation of triglyceride lipase activity (GO:0061365)3.64821433
123regulation of myeloid leukocyte mediated immunity (GO:0002886)3.64245242
124regulation of gamma-delta T cell activation (GO:0046643)3.64158570
125cellular response to type I interferon (GO:0071357)3.62758345
126type I interferon signaling pathway (GO:0060337)3.62758345
127plasma lipoprotein particle assembly (GO:0034377)3.62613675
128cofactor catabolic process (GO:0051187)3.62558721
129arginine metabolic process (GO:0006525)3.60653650
130antigen processing and presentation via MHC class Ib (GO:0002475)3.59687794
131response to type I interferon (GO:0034340)3.59134964
132positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.57028755
133macrophage activation (GO:0042116)3.56033073
134low-density lipoprotein particle remodeling (GO:0034374)3.53429735
135disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.52470305
136killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.52470305
137drug catabolic process (GO:0042737)3.52383523
138ketone body metabolic process (GO:1902224)3.52170812
139organic acid catabolic process (GO:0016054)3.50811695
140carboxylic acid catabolic process (GO:0046395)3.50811695
141short-chain fatty acid metabolic process (GO:0046459)3.50749989
142cholesterol homeostasis (GO:0042632)3.49926878
1432-oxoglutarate metabolic process (GO:0006103)3.49877871
144fatty acid beta-oxidation (GO:0006635)3.47115912
145uronic acid metabolic process (GO:0006063)3.46628088
146glucuronate metabolic process (GO:0019585)3.46628088
147serine family amino acid biosynthetic process (GO:0009070)3.46411509
148fatty acid oxidation (GO:0019395)3.45560729
149regulation of cholesterol homeostasis (GO:2000188)3.45522560
150sterol homeostasis (GO:0055092)3.45394430
151acute-phase response (GO:0006953)3.45282230
152regulation of mast cell activation involved in immune response (GO:0033006)3.42900945
153complement activation (GO:0006956)3.42687058
154lipid oxidation (GO:0034440)3.40206963
155complement activation, classical pathway (GO:0006958)3.38919501
156aspartate family amino acid catabolic process (GO:0009068)3.37106370
157monocarboxylic acid catabolic process (GO:0072329)3.36778213
158B cell mediated immunity (GO:0019724)3.36418809
159plasma lipoprotein particle organization (GO:0071827)3.35753675
160leukocyte degranulation (GO:0043299)3.35482323
161regulation of leukocyte degranulation (GO:0043300)3.34098212
162negative regulation of T cell mediated immunity (GO:0002710)3.29461523
163myeloid leukocyte mediated immunity (GO:0002444)3.22101850
164regulation of T cell tolerance induction (GO:0002664)3.19857450
165positive regulation of mast cell activation (GO:0033005)3.15509380
166positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11658479
167regulation of tolerance induction (GO:0002643)3.10534471
168regulation of mast cell activation (GO:0033003)3.09932914
169regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08289511
170regulation of T-helper 2 cell differentiation (GO:0045628)3.06764205
171regulation of gamma-delta T cell differentiation (GO:0045586)3.06460721
172regulation of T cell mediated cytotoxicity (GO:0001914)3.06398412
173B cell receptor signaling pathway (GO:0050853)3.05817401
174negative regulation of cytokine production involved in immune response (GO:0002719)3.05749631
175negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05548478
176negative regulation of innate immune response (GO:0045824)3.03345610
177negative regulation of interleukin-6 production (GO:0032715)3.01895192
178interferon-gamma-mediated signaling pathway (GO:0060333)3.00251238
179negative regulation of T-helper cell differentiation (GO:0045623)2.99630667
180negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99630667
181defense response to protozoan (GO:0042832)2.99619984
182regulation of B cell differentiation (GO:0045577)2.98838500
183dendritic cell chemotaxis (GO:0002407)2.97957831
184dendritic cell migration (GO:0036336)2.96807775
185regulation of regulated secretory pathway (GO:1903305)2.94382393
186lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94186322
187response to interferon-alpha (GO:0035455)2.93452192
188regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92504451
189germinal center formation (GO:0002467)2.91257889
190positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87788197
191positive regulation of B cell differentiation (GO:0045579)2.87639647
192neutrophil chemotaxis (GO:0030593)2.84553973
193negative regulation of type 2 immune response (GO:0002829)2.83088168
194positive regulation of interferon-alpha production (GO:0032727)2.83036524
195myeloid leukocyte activation (GO:0002274)2.80212977
196response to muramyl dipeptide (GO:0032495)2.79062632
197regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78631028
198negative regulation of alpha-beta T cell activation (GO:0046636)2.78192709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.38469835
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.49201371
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.83585429
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.75271330
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.29753018
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.66011982
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41085097
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.51232974
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34661015
10VDR_21846776_ChIP-Seq_THP-1_Human2.96773471
11* SPI1_23547873_ChIP-Seq_NB4_Human2.81463048
12VDR_24763502_ChIP-Seq_THP-1_Human2.59571611
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58782532
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50012800
15SPI1_23127762_ChIP-Seq_K562_Human2.37121513
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34286112
17MAF_26560356_Chip-Seq_TH1_Human2.26661624
18RUNX1_22412390_ChIP-Seq_EML_Mouse2.19958559
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10050763
20UTX_26944678_Chip-Seq_JUKART_Human2.09852076
21MYC_22102868_ChIP-Seq_BL_Human2.04942491
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4442348
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.95788623
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95041672
25MYB_26560356_Chip-Seq_TH2_Human1.91773659
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91541033
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89425056
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86870492
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.86739134
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85317177
31RUNX_20019798_ChIP-Seq_JUKART_Human1.85249011
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82699267
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81431873
34CLOCK_20551151_ChIP-Seq_293T_Human1.80174382
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79135517
36MAF_26560356_Chip-Seq_TH2_Human1.79089238
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79080185
38SCL_19346495_ChIP-Seq_HPC-7_Human1.78234079
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77722843
40TCF7_22412390_ChIP-Seq_EML_Mouse1.75805764
41MYB_26560356_Chip-Seq_TH1_Human1.75067143
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73379099
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72152512
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69146287
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62834627
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62268065
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58799205
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55749721
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55600707
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.53624262
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53275122
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50743254
53KDM2B_26808549_Chip-Seq_DND41_Human1.49545953
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45339805
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.43099393
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42474318
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40414358
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37986211
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.37744331
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36534944
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.36476946
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36104342
63GATA3_27048872_Chip-Seq_THYMUS_Human1.34920142
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33230047
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33022808
66GATA1_22025678_ChIP-Seq_K562_Human1.28862927
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27617424
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24196684
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23704203
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.20523733
71HNF4A_19822575_ChIP-Seq_HepG2_Human1.19345014
72VDR_24787735_ChIP-Seq_THP-1_Human1.14963775
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14707284
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14662418
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14390950
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14067354
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13308079
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10244114
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07005860
80GATA3_26560356_Chip-Seq_TH2_Human1.06940352
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.05865708
82RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05660444
83PU_27001747_Chip-Seq_BMDM_Mouse1.04921914
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.04397854
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03551116
86LXR_22292898_ChIP-Seq_THP-1_Human1.01467706
87NCOR1_26117541_ChIP-Seq_K562_Human1.01153525
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00802723
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.99927681
90P68_20966046_ChIP-Seq_HELA_Human0.99350516
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95270530
92HTT_18923047_ChIP-ChIP_STHdh_Human0.94690687
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94162731
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92250486
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91103671
96GATA4_25053715_ChIP-Seq_YYC3_Human0.90692428
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.90691021
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89275919
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82601066
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81924261
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81506787
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81441271
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.80836687
104EGR1_19032775_ChIP-ChIP_M12_Human0.80786261
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80379395
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80055425
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77502083
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77397842
109ZNF263_19887448_ChIP-Seq_K562_Human0.77195863
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76179523
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73766799
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.71401002
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71375859
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71375859
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71021314
116RACK7_27058665_Chip-Seq_MCF-7_Human0.70280336
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70205288
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.69841885
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69662100
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68441075
121GATA2_19941826_ChIP-Seq_K562_Human0.67932858
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67701953
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67583104
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.67101658
125GATA1_19941826_ChIP-Seq_K562_Human0.66938082
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66935436
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66349653
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66113645
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.65123409
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64778275
131BCOR_27268052_Chip-Seq_Bcells_Human0.61363228
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.61272595
133CEBPB_22108803_ChIP-Seq_LS180_Human0.61107826
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60877674
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60562490
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.59567508
137GATA6_25053715_ChIP-Seq_YYC3_Human0.59549485
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59504360
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58470841
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57834424
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57556812
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.57176634
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.57176634
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56937602
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.56915039
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56486563
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.55806161
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.55697524
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.55305796
150SPI1_20517297_ChIP-Seq_HL60_Human0.54988390
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54578102
152BCL6_27268052_Chip-Seq_Bcells_Human0.54305925
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.53531855
154CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53510712
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.53421528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.25305566
2MP0005360_urolithiasis6.67989790
3MP0005085_abnormal_gallbladder_physiolo5.57998204
4MP0005365_abnormal_bile_salt5.39686276
5MP0008875_abnormal_xenobiotic_pharmacok4.40402839
6MP0003806_abnormal_nucleotide_metabolis3.85984477
7MP0009840_abnormal_foam_cell3.45585557
8MP0003252_abnormal_bile_duct3.40122489
9MP0010329_abnormal_lipoprotein_level3.23299270
10MP0005083_abnormal_biliary_tract2.98858345
11MP0003191_abnormal_cellular_cholesterol2.69473775
12MP0001800_abnormal_humoral_immune2.68678313
13MP0005671_abnormal_response_to2.67182923
14MP0005000_abnormal_immune_tolerance2.62693035
15MP0005332_abnormal_amino_acid2.57891565
16MP0008260_abnormal_autophagy2.52546465
17MP0002132_abnormal_respiratory_system2.51270789
18MP0003195_calcinosis2.49587379
19MP0002723_abnormal_immune_serum2.46240842
20MP0002420_abnormal_adaptive_immunity2.42714616
21MP0001819_abnormal_immune_cell2.40478311
22MP0001666_abnormal_nutrient_absorption2.36471339
23MP0002452_abnormal_antigen_presenting2.32961388
24MP0002148_abnormal_hypersensitivity_rea2.19746068
25MP0000609_abnormal_liver_physiology2.10595899
26MP0002118_abnormal_lipid_homeostasis2.02056019
27MP0002138_abnormal_hepatobiliary_system2.00569043
28MP0004019_abnormal_vitamin_homeostasis1.99009552
29MP0002405_respiratory_system_inflammati1.93064566
30MP0005319_abnormal_enzyme/_coenzyme1.89169868
31MP0002398_abnormal_bone_marrow1.82362535
32MP0002277_abnormal_respiratory_mucosa1.81395629
33MP0010155_abnormal_intestine_physiology1.79577893
34MP0000716_abnormal_immune_system1.79078620
35MP0003763_abnormal_thymus_physiology1.76363592
36MP0009333_abnormal_splenocyte_physiolog1.74631095
37MP0003828_pulmonary_edema1.65562019
38MP0003866_abnormal_defecation1.62596898
39MP0002396_abnormal_hematopoietic_system1.60382695
40MP0003172_abnormal_lysosome_physiology1.59984982
41MP0009278_abnormal_bone_marrow1.59952637
42MP0005451_abnormal_body_composition1.58377483
43MP0005584_abnormal_enzyme/coenzyme_acti1.56305647
44MP0003705_abnormal_hypodermis_morpholog1.56073984
45MP0002722_abnormal_immune_system1.55652949
46MP0000689_abnormal_spleen_morphology1.55261561
47MP0003183_abnormal_peptide_metabolism1.53687904
48MP0001764_abnormal_homeostasis1.53533468
49MP0003436_decreased_susceptibility_to1.52363109
50MP0003186_abnormal_redox_activity1.52071615
51MP0000465_gastrointestinal_hemorrhage1.50318942
52MP0002429_abnormal_blood_cell1.46391383
53MP0009764_decreased_sensitivity_to1.43235534
54MP0003868_abnormal_feces_composition1.40640945
55MP0000858_altered_metastatic_potential1.39085087
56MP0003656_abnormal_erythrocyte_physiolo1.37898400
57MP0009643_abnormal_urine_homeostasis1.35263881
58MP0000703_abnormal_thymus_morphology1.31602852
59MP0004381_abnormal_hair_follicle1.30687340
60MP0002837_dystrophic_cardiac_calcinosis1.29706222
61MP0005058_abnormal_lysosome_morphology1.28285185
62MP0003011_delayed_dark_adaptation1.23589348
63MP0001545_abnormal_hematopoietic_system1.21654546
64MP0005397_hematopoietic_system_phenotyp1.21654546
65MP0008469_abnormal_protein_level1.21139154
66MP0000598_abnormal_liver_morphology1.16367419
67MP0001851_eye_inflammation1.14986293
68MP0000604_amyloidosis1.14049281
69MP0009763_increased_sensitivity_to1.10701569
70MP0004130_abnormal_muscle_cell1.10620073
71MP0005310_abnormal_salivary_gland1.07715856
72MP0003303_peritoneal_inflammation1.07237327
73MP0003724_increased_susceptibility_to1.07154388
74MP0005670_abnormal_white_adipose1.04140454
75MP0000490_abnormal_crypts_of0.97951248
76MP0002998_abnormal_bone_remodeling0.94725523
77MP0005636_abnormal_mineral_homeostasis0.94666483
78MP0005464_abnormal_platelet_physiology0.94605314
79MP0006036_abnormal_mitochondrial_physio0.94186372
80MP0002254_reproductive_system_inflammat0.93302595
81MP0009697_abnormal_copulation0.93117423
82MP0002971_abnormal_brown_adipose0.91201436
83MP0009785_altered_susceptibility_to0.90959332
84MP0006082_CNS_inflammation0.90854798
85MP0005647_abnormal_sex_gland0.89320139
86MP0009642_abnormal_blood_homeostasis0.88255346
87MP0002419_abnormal_innate_immunity0.86741199
88MP0003075_altered_response_to0.85467011
89MP0005390_skeleton_phenotype0.85048568
90MP0005377_hearing/vestibular/ear_phenot0.81971779
91MP0003878_abnormal_ear_physiology0.81971779
92MP0001663_abnormal_digestive_system0.81707111
93MP0004858_abnormal_nervous_system0.79876557
94MP0001853_heart_inflammation0.79745703
95MP0005376_homeostasis/metabolism_phenot0.79644383
96MP0005334_abnormal_fat_pad0.79232712
97MP0003300_gastrointestinal_ulcer0.78992201
98MP0005075_abnormal_melanosome_morpholog0.78970612
99MP0003690_abnormal_glial_cell0.78334241
100MP0003448_altered_tumor_morphology0.74949419
101MP0005025_abnormal_response_to0.74521261
102MP0001986_abnormal_taste_sensitivity0.74015300
103MP0001845_abnormal_inflammatory_respons0.73361064
104MP0002078_abnormal_glucose_homeostasis0.72624245
105MP0005666_abnormal_adipose_tissue0.72093733
106MP0009765_abnormal_xenobiotic_induced0.71947688
107MP0010368_abnormal_lymphatic_system0.70386014
108MP0005535_abnormal_body_temperature0.69993203
109MP0005166_decreased_susceptibility_to0.69104586
110MP0001533_abnormal_skeleton_physiology0.68471040
111MP0001873_stomach_inflammation0.68271339
112MP0000343_altered_response_to0.68228966
113MP0005084_abnormal_gallbladder_morpholo0.68172899
114MP0002166_altered_tumor_susceptibility0.67098352
115MP0005408_hypopigmentation0.66504238
116MP0001756_abnormal_urination0.66390277
117MP0005167_abnormal_blood-brain_barrier0.64383702
118MP0008004_abnormal_stomach_pH0.63907850
119MP0001835_abnormal_antigen_presentation0.63362647
120MP0002136_abnormal_kidney_physiology0.63249483
121MP0004782_abnormal_surfactant_physiolog0.61985829
122MP0003045_fibrosis0.61418109
123MP0003795_abnormal_bone_structure0.60359993
124MP0005266_abnormal_metabolism0.59095692
125MP0004947_skin_inflammation0.58581065
126MP0003221_abnormal_cardiomyocyte_apopto0.57856270
127MP0005448_abnormal_energy_balance0.56543019
128MP0005220_abnormal_exocrine_pancreas0.54748449
129MP0000249_abnormal_blood_vessel0.53527199
130MP0001881_abnormal_mammary_gland0.53158745
131MP0001661_extended_life_span0.53015309
132MP0009115_abnormal_fat_cell0.52825536
133MP0004185_abnormal_adipocyte_glucose0.52715221
134MP0002019_abnormal_tumor_incidence0.52651743
135MP0008873_increased_physiological_sensi0.52242557
136MP0003329_amyloid_beta_deposits0.52148165
137MP0003453_abnormal_keratinocyte_physiol0.52141414
138MP0003638_abnormal_response/metabolism_0.51699198
139MP0005164_abnormal_response_to0.51655249
140MP0004883_abnormal_blood_vessel0.50106989
141MP0000685_abnormal_immune_system0.48162657
142MP0006035_abnormal_mitochondrial_morpho0.47753155
143MP0002796_impaired_skin_barrier0.45455962
144MP0001790_abnormal_immune_system0.45008117
145MP0005387_immune_system_phenotype0.45008117
146MP0008874_decreased_physiological_sensi0.44522939
147MP0005023_abnormal_wound_healing0.44379547
148MP0009053_abnormal_anal_canal0.44268157
149MP0002928_abnormal_bile_duct0.43542924
150MP0004510_myositis0.40561431
151MP0002876_abnormal_thyroid_physiology0.40119658

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.58389463
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.44842987
3Recurrent abscess formation (HP:0002722)6.42816564
4Intrahepatic cholestasis (HP:0001406)6.23217032
5Myositis (HP:0100614)5.92176655
6Abnormality of macrophages (HP:0004311)5.88473034
7Xanthomatosis (HP:0000991)5.77533461
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.77244330
9Orchitis (HP:0100796)5.53849352
10Prolonged partial thromboplastin time (HP:0003645)5.48426751
11Hypobetalipoproteinemia (HP:0003563)5.23877708
12Complement deficiency (HP:0004431)5.05465427
13Hyperlipoproteinemia (HP:0010980)5.01950074
14Optic neuritis (HP:0100653)4.99291448
15Retrobulbar optic neuritis (HP:0100654)4.99291448
16Stomatitis (HP:0010280)4.82812101
17Obstructive lung disease (HP:0006536)4.70610847
18Chronic obstructive pulmonary disease (HP:0006510)4.70610847
19Elevated erythrocyte sedimentation rate (HP:0003565)4.63072368
20Joint hemorrhage (HP:0005261)4.62336104
21Hyperammonemia (HP:0001987)4.28732869
22Gastrointestinal infarctions (HP:0005244)4.26775247
23Hypolipoproteinemia (HP:0010981)4.12899597
24Mediastinal lymphadenopathy (HP:0100721)4.10811905
25Meningitis (HP:0001287)4.10611527
26Ketosis (HP:0001946)4.09464768
27Abnormality of the common coagulation pathway (HP:0010990)4.09415342
28Hypochromic anemia (HP:0001931)3.97572601
29Recurrent fungal infections (HP:0002841)3.95756930
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.94820316
31Recurrent skin infections (HP:0001581)3.94221438
32Epidermoid cyst (HP:0200040)3.93532314
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.89901016
34Hyperglycinemia (HP:0002154)3.87352178
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.86168584
36Urticaria (HP:0001025)3.85220313
37Abnormality of complement system (HP:0005339)3.84169976
38Hypoalphalipoproteinemia (HP:0003233)3.82761687
39Abnormality of sulfur amino acid metabolism (HP:0004339)3.82211402
40Hyperglycinuria (HP:0003108)3.81778788
41Encephalitis (HP:0002383)3.80931481
42Recurrent gram-negative bacterial infections (HP:0005420)3.78477835
43Abnormality of serine family amino acid metabolism (HP:0010894)3.67561632
44Abnormality of glycine metabolism (HP:0010895)3.67561632
45Hypoglycemic coma (HP:0001325)3.65844395
46Fat malabsorption (HP:0002630)3.64960814
47Increased IgE level (HP:0003212)3.64641297
48Keratoconjunctivitis sicca (HP:0001097)3.62479118
49Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61157840
50Abnormality of methionine metabolism (HP:0010901)3.57436285
51Gingivitis (HP:0000230)3.54647860
52Abnormality of fatty-acid metabolism (HP:0004359)3.51440140
53Prolonged bleeding time (HP:0003010)3.43492218
54Spontaneous hematomas (HP:0007420)3.40813621
55Systemic lupus erythematosus (HP:0002725)3.38122595
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33157930
57Keratoconjunctivitis (HP:0001096)3.31641124
58Abnormality of the intrinsic pathway (HP:0010989)3.31261818
59Hypercholesterolemia (HP:0003124)3.30329964
60Chronic mucocutaneous candidiasis (HP:0002728)3.29641681
61Recurrent cutaneous fungal infections (HP:0011370)3.29641681
62Episodic fever (HP:0001954)3.28509607
63Vasculitis (HP:0002633)3.24835124
64Abnormality of pyrimidine metabolism (HP:0004353)3.23854288
65Myocardial infarction (HP:0001658)3.23131378
66Cellulitis (HP:0100658)3.22474717
67Petechiae (HP:0000967)3.16005697
68Anorexia (HP:0002039)3.10561261
69Chest pain (HP:0100749)3.05686089
70Abnormality of nucleobase metabolism (HP:0010932)3.03119071
71Ketoacidosis (HP:0001993)3.02580532
72Peritonitis (HP:0002586)2.93137376
73Abnormality of purine metabolism (HP:0004352)2.92751462
74Hyperbilirubinemia (HP:0002904)2.91107529
75Conjugated hyperbilirubinemia (HP:0002908)2.89421110
76Steatorrhea (HP:0002570)2.87424753
77Epistaxis (HP:0000421)2.85867304
78Microcytic anemia (HP:0001935)2.85577555
79Hemoptysis (HP:0002105)2.71731923
80Purpura (HP:0000979)2.69791217
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67071195
82Dicarboxylic aciduria (HP:0003215)2.67071195
83Abnormality of serum amino acid levels (HP:0003112)2.66892498
84Pulmonary infiltrates (HP:0002113)2.66886111
85Skin nodule (HP:0200036)2.66129992
86Metabolic acidosis (HP:0001942)2.64675085
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.64362740
88Hepatocellular carcinoma (HP:0001402)2.64029639
89Inflammation of the large intestine (HP:0002037)2.61912339
90Gout (HP:0001997)2.61383910
91Delayed CNS myelination (HP:0002188)2.61046097
92Vascular calcification (HP:0004934)2.59996627
93Osteomyelitis (HP:0002754)2.59372014
94Arterial thrombosis (HP:0004420)2.58988024
95Increased IgM level (HP:0003496)2.58810174
96Gastrointestinal inflammation (HP:0004386)2.58752244
97Glomerulonephritis (HP:0000099)2.56200154
98Panhypogammaglobulinemia (HP:0003139)2.53336099
99Amyloidosis (HP:0011034)2.50985618
100Leukocytosis (HP:0001974)2.49569480
101Hepatosplenomegaly (HP:0001433)2.47444887
102Spontaneous abortion (HP:0005268)2.43238759
103Lethargy (HP:0001254)2.42047558
104Gangrene (HP:0100758)2.40549717
105Granulocytopenia (HP:0001913)2.39144402
106Recurrent viral infections (HP:0004429)2.39128717
107Gingival bleeding (HP:0000225)2.37437579
108Sepsis (HP:0100806)2.37416107
109Mitral stenosis (HP:0001718)2.36555429
110Cholelithiasis (HP:0001081)2.34341257
111Abnormal gallbladder morphology (HP:0012437)2.33118697
112Cardiovascular calcification (HP:0011915)2.33046777
113Abnormality of T cells (HP:0002843)2.30817532
114Pustule (HP:0200039)2.30793004
115Hypochromic microcytic anemia (HP:0004840)2.29696274
116Esophageal varix (HP:0002040)2.28308391
117Abnormality of the pleura (HP:0002103)2.26705044
118Generalized aminoaciduria (HP:0002909)2.26527506
119Spastic diplegia (HP:0001264)2.26361740
120Menorrhagia (HP:0000132)2.24419619
121Cerebral edema (HP:0002181)2.24241824
122Axonal loss (HP:0003447)2.23714237
123Abnormality of T cell physiology (HP:0011840)2.23546678
124Hypergammaglobulinemia (HP:0010702)2.23235399
125T lymphocytopenia (HP:0005403)2.21102646
126Abnormality of iron homeostasis (HP:0011031)2.20967759
127Pancreatitis (HP:0001733)2.19073576
128Malnutrition (HP:0004395)2.17962190
129Skin ulcer (HP:0200042)2.17227343
130Lymphopenia (HP:0001888)2.16349094
131Abnormal platelet volume (HP:0011876)2.15877821
132Hemorrhage of the eye (HP:0011885)2.15137267
133Neonatal onset (HP:0003623)2.15003889
134Abnormality of the peritoneum (HP:0002585)2.14880704
135Abnormality of T cell number (HP:0011839)2.14447850
136Acute hepatic failure (HP:0006554)2.12193898
137Cholecystitis (HP:0001082)2.11678296
138Abnormal gallbladder physiology (HP:0012438)2.11678296
139Vomiting (HP:0002013)2.11665813
140Irritability (HP:0000737)2.11489136
141Abnormality of transition element cation homeostasis (HP:0011030)2.11289740
142Sensorimotor neuropathy (HP:0007141)2.10685281
143Acne (HP:0001061)2.10001648
144Abnormality of proline metabolism (HP:0010907)2.09756623
145Hydroxyprolinuria (HP:0003080)2.09756623
146Late onset (HP:0003584)2.09568815
147Toxemia of pregnancy (HP:0100603)2.06835391
148Abnormality of the pericardium (HP:0001697)2.05124259
149Thrombophlebitis (HP:0004418)2.05019584
150Nephritis (HP:0000123)2.03412089
151Premature loss of primary teeth (HP:0006323)2.03194989
152Skin rash (HP:0000988)2.01638268
153Glomerulopathy (HP:0100820)2.01014112
154Hypoglycemic seizures (HP:0002173)2.00884208
155Abnormality of cells of the lymphoid lineage (HP:0012140)2.00721280
156Nausea (HP:0002018)2.00124184
157Abnormality of the endocardium (HP:0004306)1.99257254
158Abnormal enzyme/coenzyme activity (HP:0012379)1.96466049
159Recurrent pneumonia (HP:0006532)1.95811383
160Colitis (HP:0002583)1.94910220
161Eczematoid dermatitis (HP:0000976)1.94678527
162Chronic otitis media (HP:0000389)1.94088816
163Abnormal cartilage morphology (HP:0002763)1.93645916
164Metaphyseal cupping (HP:0003021)1.92634027
165IgM deficiency (HP:0002850)1.92094974
166Increased serum ferritin (HP:0003281)1.91878309
167Polycythemia (HP:0001901)1.91857534
168Hypermelanotic macule (HP:0001034)1.91628755
169Opisthotonus (HP:0002179)1.89268367
170Acanthocytosis (HP:0001927)1.87909532
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87865866
172Keratitis (HP:0000491)1.87193230
173Abnormality of the gallbladder (HP:0005264)1.86662818
174Loss of speech (HP:0002371)1.86574142
175Pulmonary embolism (HP:0002204)1.86396487
176Hyperuricemia (HP:0002149)1.84663250
177Increased purine levels (HP:0004368)1.84663250
178Eosinophilia (HP:0001880)1.82295690
179Splenomegaly (HP:0001744)1.82153498
180Proximal tubulopathy (HP:0000114)1.81657657
181Recurrent lower respiratory tract infections (HP:0002783)1.81648375
182Increased cerebral lipofuscin (HP:0011813)1.80598937
183Hypertriglyceridemia (HP:0002155)1.78910750
184Elevated alkaline phosphatase (HP:0003155)1.77990364
185Recurrent bacterial skin infections (HP:0005406)1.76376885
186Vacuolated lymphocytes (HP:0001922)1.76207918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.43046446
2ERN15.13573431
3RIPK44.94086982
4FGFR43.31651271
5SIK13.27674383
6TRIB33.19701797
7PKN22.75312061
8TNK22.67170041
9FES2.41224613
10TAOK32.40176780
11EPHB12.24660387
12TAOK12.24356162
13MST1R2.07626212
14TYK22.04843887
15PRPF4B1.88566888
16TBK11.85605341
17MAP2K31.76244037
18PIK3CG1.63812298
19TESK21.62939777
20ERBB41.62165221
21TTN1.60242413
22PTK61.59740515
23GRK61.52072707
24FLT31.47494991
25SYK1.47175997
26INSRR1.45954643
27CSK1.44010741
28ABL21.43369629
29SIK31.43230911
30BLK1.39811209
31MAPK111.37594799
32NEK91.37298856
33MAP3K141.37177105
34LYN1.33967963
35IRAK31.32586260
36SMG11.30416712
37KDR1.29088499
38TAOK21.28749044
39JAK21.27763494
40YES11.27252652
41RIPK11.25572974
42MAP4K11.24204943
43TXK1.23388728
44MAP3K31.22781068
45TGFBR21.17864026
46MAP2K41.17674636
47JAK11.13342042
48PRKD21.11798853
49MAP3K111.06823739
50CDK191.03397989
51LCK1.03350975
52PRKAA21.00682547
53CAMK1D0.99606904
54IRAK40.94055497
55IKBKE0.93764753
56MARK30.93479901
57MAP3K70.92514741
58MAP3K60.90892806
59MAPK40.87816122
60MARK20.86648563
61CSF1R0.83891350
62IRAK10.83628195
63BMX0.82940916
64LRRK20.82770157
65ZAP700.81261280
66MYLK0.79205819
67IRAK20.78238342
68FRK0.76674615
69DAPK20.75942860
70KIT0.75938106
71EPHA30.75120242
72BTK0.74729811
73MET0.74162868
74MAP3K100.73465265
75PINK10.72841475
76CDK60.71627941
77PIK3CA0.71437796
78LATS10.68879012
79MAPK120.68402332
80MAP3K130.67134292
81PTK20.67043985
82MAP3K20.65465001
83GSK3A0.62150142
84FGFR30.61385430
85FYN0.61357970
86PDPK10.60479206
87MAP2K20.58923914
88STK100.57798144
89PTK2B0.57279681
90PRKACG0.57044173
91RAF10.53878691
92IKBKB0.53424372
93OBSCN0.53128212
94FGR0.52328118
95PRKCZ0.52158500
96MAP3K10.51482216
97HCK0.50784813
98PRKAA10.50469353
99MAP3K50.49515598
100KSR20.49334106
101SIK20.48310973
102STK380.48050335
103MAP3K80.47870117
104MAPKAPK20.46978128
105JAK30.45867472
106MAP2K60.45812200
107STK110.45424114
108EGFR0.44935720
109TIE10.44772183
110PAK40.44613504
111DYRK1B0.44036371
112ERBB20.43248970
113ITK0.42769814
114TRPM70.42166093
115PRKG20.41838385
116MAP2K10.41408484
117RPS6KL10.40771179
118RPS6KC10.40771179
119DYRK30.40503288
120PDK10.38393924
121ABL10.38223317
122CAMK1G0.38099283
123CDC42BPA0.37958432
124FGFR20.37867631
125PRKCQ0.37850746
126CAMK2G0.37592777
127RET0.37012844
128ALK0.36985254
129PDK40.36499907
130PDK30.36499907
131NME20.36381662
132PIM10.35601993
133STK38L0.35065839
134HIPK20.34667305
135SGK30.33681841
136MATK0.33306316
137PRKCD0.33098209
138TEC0.32875921
139RPS6KA60.30099120
140BMPR20.29826155
141MAPK70.28772233
142PRKD10.27661882
143MAP3K120.25041766

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.24516422
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38828524
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26091826
4Nitrogen metabolism_Homo sapiens_hsa009103.23044828
5Arginine biosynthesis_Homo sapiens_hsa002202.96774266
6Complement and coagulation cascades_Homo sapiens_hsa046102.73267744
7Tryptophan metabolism_Homo sapiens_hsa003802.61344996
8Fatty acid degradation_Homo sapiens_hsa000712.59414002
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56776995
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53997071
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48044207
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47944111
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.44235900
14Graft-versus-host disease_Homo sapiens_hsa053322.35512139
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34566024
16Allograft rejection_Homo sapiens_hsa053302.33256316
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32715089
18B cell receptor signaling pathway_Homo sapiens_hsa046622.24733616
19Primary immunodeficiency_Homo sapiens_hsa053402.24016213
20Staphylococcus aureus infection_Homo sapiens_hsa051502.21683119
21Autoimmune thyroid disease_Homo sapiens_hsa053202.16331088
22Peroxisome_Homo sapiens_hsa041462.11914811
23Propanoate metabolism_Homo sapiens_hsa006402.04687943
24Butanoate metabolism_Homo sapiens_hsa006502.03017614
25Caffeine metabolism_Homo sapiens_hsa002321.99073586
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96435326
27PPAR signaling pathway_Homo sapiens_hsa033201.95657523
28Histidine metabolism_Homo sapiens_hsa003401.91328038
29Measles_Homo sapiens_hsa051621.87596595
30Fatty acid metabolism_Homo sapiens_hsa012121.87201767
31Acute myeloid leukemia_Homo sapiens_hsa052211.86775521
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82064194
33Chemical carcinogenesis_Homo sapiens_hsa052041.80094509
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78180494
35Chemokine signaling pathway_Homo sapiens_hsa040621.75983223
36beta-Alanine metabolism_Homo sapiens_hsa004101.74680525
37Antigen processing and presentation_Homo sapiens_hsa046121.73742119
38Phagosome_Homo sapiens_hsa041451.69346846
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68833025
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.68369251
41Viral myocarditis_Homo sapiens_hsa054161.65961426
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64516320
43Hematopoietic cell lineage_Homo sapiens_hsa046401.62264538
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.60733647
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58087445
46Type I diabetes mellitus_Homo sapiens_hsa049401.57305453
47Retinol metabolism_Homo sapiens_hsa008301.53939040
48Phenylalanine metabolism_Homo sapiens_hsa003601.53797449
49Influenza A_Homo sapiens_hsa051641.52846431
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48269358
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47339596
52Toxoplasmosis_Homo sapiens_hsa051451.46750012
53Herpes simplex infection_Homo sapiens_hsa051681.46503587
54Starch and sucrose metabolism_Homo sapiens_hsa005001.42813772
55Selenocompound metabolism_Homo sapiens_hsa004501.42473881
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40647914
57Pyruvate metabolism_Homo sapiens_hsa006201.39569436
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.39257118
59Bile secretion_Homo sapiens_hsa049761.36431584
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.34943864
61T cell receptor signaling pathway_Homo sapiens_hsa046601.33653328
62Tyrosine metabolism_Homo sapiens_hsa003501.31883622
63Carbon metabolism_Homo sapiens_hsa012001.28777909
64Sulfur metabolism_Homo sapiens_hsa009201.28616817
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25776295
66Fatty acid elongation_Homo sapiens_hsa000621.24979616
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.23877873
68Folate biosynthesis_Homo sapiens_hsa007901.21279231
69Shigellosis_Homo sapiens_hsa051311.19559387
70Fat digestion and absorption_Homo sapiens_hsa049751.19487509
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19014178
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18754058
73Biosynthesis of amino acids_Homo sapiens_hsa012301.18188783
74Non-small cell lung cancer_Homo sapiens_hsa052231.16867417
75ABC transporters_Homo sapiens_hsa020101.14006194
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12899945
77Cysteine and methionine metabolism_Homo sapiens_hsa002701.09842175
78Steroid biosynthesis_Homo sapiens_hsa001001.06787652
79Hepatitis B_Homo sapiens_hsa051611.03411769
80Salmonella infection_Homo sapiens_hsa051321.03070403
81Platelet activation_Homo sapiens_hsa046111.02131888
82TNF signaling pathway_Homo sapiens_hsa046681.02058332
83Sulfur relay system_Homo sapiens_hsa041220.99244617
84Arginine and proline metabolism_Homo sapiens_hsa003300.96462982
85Pancreatic cancer_Homo sapiens_hsa052120.95407121
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94160549
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93396444
88Apoptosis_Homo sapiens_hsa042100.93382423
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.91634852
90Endocytosis_Homo sapiens_hsa041440.87691235
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86704277
92Chronic myeloid leukemia_Homo sapiens_hsa052200.81299476
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.80067008
94Vitamin digestion and absorption_Homo sapiens_hsa049770.79994471
95Epstein-Barr virus infection_Homo sapiens_hsa051690.78456570
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78406960
97Asthma_Homo sapiens_hsa053100.77993578
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77447009
99Pentose phosphate pathway_Homo sapiens_hsa000300.77367675
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77018162
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77005991
102Glycerolipid metabolism_Homo sapiens_hsa005610.76443318
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76161178
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75647960
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75157523
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74462295
107Lysine degradation_Homo sapiens_hsa003100.74409588
108VEGF signaling pathway_Homo sapiens_hsa043700.73623830
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72008713
110Glutathione metabolism_Homo sapiens_hsa004800.71166407
111Rheumatoid arthritis_Homo sapiens_hsa053230.70574022
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.69503846
113Vitamin B6 metabolism_Homo sapiens_hsa007500.69403544
114Regulation of autophagy_Homo sapiens_hsa041400.68249514
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65416391
116Renal cell carcinoma_Homo sapiens_hsa052110.60746940
117Fatty acid biosynthesis_Homo sapiens_hsa000610.59177050
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56744116
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.56539522
120Viral carcinogenesis_Homo sapiens_hsa052030.55873424
121Collecting duct acid secretion_Homo sapiens_hsa049660.53803793
122One carbon pool by folate_Homo sapiens_hsa006700.50850031
123Prolactin signaling pathway_Homo sapiens_hsa049170.50838185
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.48106979
125Endometrial cancer_Homo sapiens_hsa052130.48023120
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47258032
127FoxO signaling pathway_Homo sapiens_hsa040680.46758708
128HIF-1 signaling pathway_Homo sapiens_hsa040660.45334341
129Notch signaling pathway_Homo sapiens_hsa043300.41973148
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.41605128
131Metabolic pathways_Homo sapiens_hsa011000.41058326
132Galactose metabolism_Homo sapiens_hsa000520.40878661
133Insulin resistance_Homo sapiens_hsa049310.40582395
134HTLV-I infection_Homo sapiens_hsa051660.38619037
135Choline metabolism in cancer_Homo sapiens_hsa052310.38165815
136Fructose and mannose metabolism_Homo sapiens_hsa000510.36562193
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.36073432
138Prion diseases_Homo sapiens_hsa050200.35700502
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32896417
140Colorectal cancer_Homo sapiens_hsa052100.29595633
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.23603726
142Inositol phosphate metabolism_Homo sapiens_hsa005620.21978247
143Thyroid cancer_Homo sapiens_hsa052160.20902354
144Rap1 signaling pathway_Homo sapiens_hsa040150.20040632
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19818409
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17414025
147Lysosome_Homo sapiens_hsa041420.16024836
148Linoleic acid metabolism_Homo sapiens_hsa005910.12868759
149Leishmaniasis_Homo sapiens_hsa051400.12726638
150Pertussis_Homo sapiens_hsa051330.11083147
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.09703397
152AMPK signaling pathway_Homo sapiens_hsa041520.07807342
153Legionellosis_Homo sapiens_hsa051340.06364227
154Glucagon signaling pathway_Homo sapiens_hsa049220.04349280
155Other glycan degradation_Homo sapiens_hsa005110.03782536
156Malaria_Homo sapiens_hsa051440.02236568
157Toll-like receptor signaling pathway_Homo sapiens_hsa046200.00547777
158Amoebiasis_Homo sapiens_hsa051460.00247887
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00049989
160Renin-angiotensin system_Homo sapiens_hsa04614-0.0960793
161Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0938961
162Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0886993
163Osteoclast differentiation_Homo sapiens_hsa04380-0.0647664
164Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0586658
165African trypanosomiasis_Homo sapiens_hsa05143-0.0555415
166Tuberculosis_Homo sapiens_hsa05152-0.0528085
167Hepatitis C_Homo sapiens_hsa05160-0.0355589
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0337005
169Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0264495
170Insulin signaling pathway_Homo sapiens_hsa04910-0.0144302

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