MSLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.72534645
2hemidesmosome assembly (GO:0031581)7.16651356
3cell adhesion mediated by integrin (GO:0033627)6.96762081
4mesodermal cell differentiation (GO:0048333)6.41754504
5motile cilium assembly (GO:0044458)5.77036309
6COPI coating of Golgi vesicle (GO:0048205)5.49991251
7Golgi transport vesicle coating (GO:0048200)5.49991251
8diterpenoid biosynthetic process (GO:0016102)5.28701954
9cilium or flagellum-dependent cell motility (GO:0001539)5.12089751
10skin morphogenesis (GO:0043589)4.96305273
11hepatocyte apoptotic process (GO:0097284)4.77479153
12positive regulation of osteoblast proliferation (GO:0033690)4.74871929
13establishment or maintenance of monopolar cell polarity (GO:0061339)4.70107541
14establishment of monopolar cell polarity (GO:0061162)4.70107541
15negative regulation of humoral immune response (GO:0002921)4.67967637
16renal filtration (GO:0097205)4.51769915
17glial cell proliferation (GO:0014009)4.50055605
18cilium movement (GO:0003341)4.40313040
19hypotonic response (GO:0006971)4.40030530
20positive regulation of establishment of protein localization to plasma membrane (GO:0090004)4.36816420
21interferon-gamma secretion (GO:0072643)4.22757936
22cytoskeletal anchoring at plasma membrane (GO:0007016)4.22129661
23glomerular epithelial cell development (GO:0072310)4.18358430
24ear development (GO:0043583)4.16888776
25positive regulation of protein localization to plasma membrane (GO:1903078)4.12967663
26activation of Rac GTPase activity (GO:0032863)4.09626431
27lung epithelium development (GO:0060428)4.08657147
28planar cell polarity pathway involved in neural tube closure (GO:0090179)4.02699264
29negative regulation of complement activation (GO:0045916)3.97997162
30L-ascorbic acid metabolic process (GO:0019852)3.94904645
31cell-substrate junction assembly (GO:0007044)3.94164078
32hepatocyte differentiation (GO:0070365)3.92888116
33tight junction assembly (GO:0070830)3.91242430
34regulation of hippo signaling (GO:0035330)3.89987752
35primary alcohol catabolic process (GO:0034310)3.84358105
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.84108911
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.82499648
38epithelial cell-cell adhesion (GO:0090136)3.82475095
39terpenoid biosynthetic process (GO:0016114)3.81647004
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.67366230
41desmosome organization (GO:0002934)3.66038010
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.61106516
43renal system development (GO:0072001)3.58705549
44chemical homeostasis within a tissue (GO:0048875)3.58475702
45branching involved in salivary gland morphogenesis (GO:0060445)3.55456604
46extracellular fibril organization (GO:0043206)3.53362370
47molting cycle (GO:0042303)3.52228447
48hair cycle (GO:0042633)3.52228447
49epithelial cilium movement (GO:0003351)3.49982005
50negative regulation of protein activation cascade (GO:2000258)3.47499642
51response to water (GO:0009415)3.46044486
52detection of bacterium (GO:0016045)3.43616948
53citrulline biosynthetic process (GO:0019240)3.42482027
54positive regulation of positive chemotaxis (GO:0050927)3.41478395
55membrane budding (GO:0006900)3.40176955
56regulation of alkaline phosphatase activity (GO:0010692)3.39766806
57protein retention in ER lumen (GO:0006621)3.38764910
58O-glycan processing (GO:0016266)3.36084633
59hippo signaling (GO:0035329)3.34879821
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33917128
61epithelial tube branching involved in lung morphogenesis (GO:0060441)3.33711397
62positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.33522953
63lung-associated mesenchyme development (GO:0060484)3.30237138
64left/right pattern formation (GO:0060972)3.29361754
65organ formation (GO:0048645)3.29180620
66respiratory tube development (GO:0030323)3.29098708
67negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27823156
68citrulline metabolic process (GO:0000052)3.26449371
69regulation of positive chemotaxis (GO:0050926)3.24277977
70retinal metabolic process (GO:0042574)3.23855788
71substrate-dependent cell migration (GO:0006929)3.22595958
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.21754832
73positive regulation of Cdc42 GTPase activity (GO:0043089)3.21752690
74lens fiber cell development (GO:0070307)3.19992692
75intestinal epithelial cell development (GO:0060576)3.17233601
76vitamin transmembrane transport (GO:0035461)3.14295165
77fibril organization (GO:0097435)3.11903300
78detection of other organism (GO:0098543)3.11574041
79establishment of planar polarity (GO:0001736)3.11200903
80establishment of tissue polarity (GO:0007164)3.11200903
81cellular response to arsenic-containing substance (GO:0071243)3.10437405
82plasma membrane repair (GO:0001778)3.08897710
83adherens junction assembly (GO:0034333)3.08025193
844-hydroxyproline metabolic process (GO:0019471)3.03046404
85apoptotic process involved in morphogenesis (GO:0060561)3.02605167
86apoptotic cell clearance (GO:0043277)3.01477464
87endodermal cell differentiation (GO:0035987)3.00655350
88semaphorin-plexin signaling pathway (GO:0071526)2.99957302
89atrioventricular valve morphogenesis (GO:0003181)2.98287194
90establishment of skin barrier (GO:0061436)2.97811208
91establishment of apical/basal cell polarity (GO:0035089)2.96512536
92cell-cell junction assembly (GO:0007043)2.95455513
93negative regulation of chondrocyte differentiation (GO:0032331)2.94798914
94water homeostasis (GO:0030104)2.93712147
95embryonic camera-type eye development (GO:0031076)2.93073688
96surfactant homeostasis (GO:0043129)2.92960000
97retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92019074
98keratinocyte differentiation (GO:0030216)2.90681715
99regulation of glomerular filtration (GO:0003093)2.88939448
100regulation of interleukin-8 secretion (GO:2000482)2.87398251
101cell junction assembly (GO:0034329)2.87174119
102peptide cross-linking (GO:0018149)2.86731825
103keratinocyte proliferation (GO:0043616)2.86386401
104establishment or maintenance of apical/basal cell polarity (GO:0035088)2.86349310
105establishment or maintenance of bipolar cell polarity (GO:0061245)2.86349310
106regulation of ruffle assembly (GO:1900027)2.83799898
107filopodium assembly (GO:0046847)2.83201776
108regulation of osteoblast proliferation (GO:0033688)2.83191447
109regulation of cardioblast differentiation (GO:0051890)2.81819616
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.79335592
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.79170211
112regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.79163547
113one-carbon compound transport (GO:0019755)2.78640531
114ethanol metabolic process (GO:0006067)2.77793999
115regulation of establishment of protein localization to plasma membrane (GO:0090003)2.77284085
116chondrocyte proliferation (GO:0035988)2.76250748
117multicellular organismal water homeostasis (GO:0050891)2.76107371
118positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.74555490
119embryonic foregut morphogenesis (GO:0048617)2.74382219
120basement membrane organization (GO:0071711)2.73904501
121positive regulation of hormone biosynthetic process (GO:0046886)2.72700037
122positive regulation of endothelial cell apoptotic process (GO:2000353)2.71253860
123regulation of chemokine secretion (GO:0090196)2.70379772
124gas transport (GO:0015669)2.70351228
125phospholipid scrambling (GO:0017121)2.70183331
126regulation of transmission of nerve impulse (GO:0051969)2.69681343
127endoplasmic reticulum unfolded protein response (GO:0030968)2.69221271
128polarized epithelial cell differentiation (GO:0030859)2.69118846
129lung lobe morphogenesis (GO:0060463)2.69023514
130barbed-end actin filament capping (GO:0051016)2.67520487
131regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.67167047
132epidermis development (GO:0008544)2.66974691
133embryonic viscerocranium morphogenesis (GO:0048703)2.66897576
134COPII vesicle coating (GO:0048208)2.66618882
135focal adhesion assembly (GO:0048041)2.66361238
136cell-substrate adherens junction assembly (GO:0007045)2.66361238
137negative regulation of T cell differentiation in thymus (GO:0033085)2.66190031
138dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65968430
139negative regulation of transcription by competitive promoter binding (GO:0010944)2.64987677
140adherens junction organization (GO:0034332)2.64888042
141ventricular cardiac muscle cell action potential (GO:0086005)2.64635027
142cell junction organization (GO:0034330)2.64529714
143natural killer cell mediated immunity (GO:0002228)2.64249146
144natural killer cell mediated cytotoxicity (GO:0042267)2.64249146
145cellular response to unfolded protein (GO:0034620)2.64051370
146kidney morphogenesis (GO:0060993)2.63906023
147regulation of skeletal muscle contraction (GO:0014819)2.63656489
148Rho protein signal transduction (GO:0007266)2.63446173
149cell-cell junction maintenance (GO:0045217)2.63356362
150regulation of podosome assembly (GO:0071801)2.63309448
151regulation of establishment of planar polarity (GO:0090175)2.63192166
152asymmetric protein localization (GO:0008105)2.62776558
153endocrine pancreas development (GO:0031018)2.62197843
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62036612
155regulation of water loss via skin (GO:0033561)2.61715797
156morphogenesis of embryonic epithelium (GO:0016331)2.60510068
157regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58752657
158cell differentiation involved in embryonic placenta development (GO:0060706)2.58672573
159acrosome reaction (GO:0007340)2.57022942
160embryonic process involved in female pregnancy (GO:0060136)2.56843644
161negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56085350
162diaphragm development (GO:0060539)2.54423956
163glomerular visceral epithelial cell development (GO:0072015)2.52570755
164pyrimidine-containing compound transmembrane transport (GO:0072531)2.49800966
165regulation of transforming growth factor beta2 production (GO:0032909)2.49599024
166regulation of Cdc42 GTPase activity (GO:0043088)2.49430129
167striated muscle atrophy (GO:0014891)2.49284390
168regulation of transforming growth factor beta1 production (GO:0032908)2.48938136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.28493022
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.33038586
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.20824247
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.46137996
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.87878573
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.96949634
7CLOCK_20551151_ChIP-Seq_293T_Human2.88108129
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80459721
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71395101
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.61888499
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.56917018
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.49175279
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.49175279
14ZNF263_19887448_ChIP-Seq_K562_Human2.46001387
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.28527256
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.19022673
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.14576053
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.05879100
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.03278047
20* SOX2_20726797_ChIP-Seq_SW620_Human1.95042498
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93706415
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91494308
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.90658186
24ATF3_27146783_Chip-Seq_COLON_Human1.88129625
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86173271
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81333917
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74009470
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72515716
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71214705
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69316335
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66282017
32CJUN_26792858_Chip-Seq_BT549_Human1.65520023
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.64076815
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63342434
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61685936
36* SMC4_20622854_ChIP-Seq_HELA_Human1.59790984
37RACK7_27058665_Chip-Seq_MCF-7_Human1.59717338
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.58235960
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56658709
40GATA4_25053715_ChIP-Seq_YYC3_Human1.56326925
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53546729
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53386032
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52066709
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49963797
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48464954
46GATA6_25053715_ChIP-Seq_YYC3_Human1.47706514
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.47183718
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47055040
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46642587
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46248693
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45260980
52ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45184934
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.43426313
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40053914
55KLF5_25053715_ChIP-Seq_YYC3_Human1.39547444
56CREB1_26743006_Chip-Seq_LNCaP_Human1.38776119
57P68_20966046_ChIP-Seq_HELA_Human1.37203144
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.35084582
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.33072272
60KDM2B_26808549_Chip-Seq_K562_Human1.32878918
61* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32567217
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31950985
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31405610
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31405610
65TP63_22573176_ChIP-Seq_HFKS_Human1.30478982
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.29669042
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.28380210
68VDR_21846776_ChIP-Seq_THP-1_Human1.28137869
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27618365
70EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25762684
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24108745
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.23645593
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.22618153
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19546219
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19538993
76BRD4_25478319_ChIP-Seq_HGPS_Human1.17101875
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17008410
78TCF7_22412390_ChIP-Seq_EML_Mouse1.15785524
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15716560
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13165843
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12321123
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10553533
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.10354220
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09998718
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09596829
86AR_21909140_ChIP-Seq_LNCAP_Human1.07630691
87KDM2B_26808549_Chip-Seq_DND41_Human1.07611199
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06809236
89* CTCF_27219007_Chip-Seq_Bcells_Human1.06014646
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05354216
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05213192
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04837682
93TP53_22127205_ChIP-Seq_IMR90_Human1.03363546
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02166078
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02044328
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00982247
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00743319
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00644715
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00277369
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00185698
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.00161218
102TET1_21451524_ChIP-Seq_MESCs_Mouse0.99518831
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98677367
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97919078
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97498672
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97422482
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97065758
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96685494
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96404114
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96377873
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96269927
112LXR_22292898_ChIP-Seq_THP-1_Human0.94492993
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93861315
114CHD1_26751641_Chip-Seq_LNCaP_Human0.93333642
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.93326529
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.93326529
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93212907
118NCOR1_26117541_ChIP-Seq_K562_Human0.92637000
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92635156
120RXR_22158963_ChIP-Seq_LIVER_Mouse0.92633004
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90604477
122TP53_18474530_ChIP-ChIP_U2OS_Human0.89918485
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89543156
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89144390
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88078432
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87998218
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87129390
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86771803
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.85312062
130BCOR_27268052_Chip-Seq_Bcells_Human0.85137211
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84770725
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84270006
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83950805
134AHR_22903824_ChIP-Seq_MCF-7_Human0.82734173
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81898500
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81583002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology4.76440925
2MP0010234_abnormal_vibrissa_follicle4.64636951
3MP0002877_abnormal_melanocyte_morpholog4.40745127
4MP0000566_synostosis3.15051206
5MP0000579_abnormal_nail_morphology3.06087839
6MP0003566_abnormal_cell_adhesion3.02584204
7MP0004272_abnormal_basement_membrane2.86692711
8MP0004264_abnormal_extraembryonic_tissu2.75842153
9MP0003705_abnormal_hypodermis_morpholog2.66583727
10MP0005409_darkened_coat_color2.54459278
11MP0010352_gastrointestinal_tract_polyps2.53477065
12MP0001849_ear_inflammation2.42663658
13MP0005623_abnormal_meninges_morphology2.26668565
14MP0003453_abnormal_keratinocyte_physiol2.25236414
15MP0006054_spinal_hemorrhage2.24454081
16MP0002234_abnormal_pharynx_morphology2.18896765
17MP0005275_abnormal_skin_tensile2.15418264
18MP0009780_abnormal_chondrocyte_physiolo2.11593105
19MP0003115_abnormal_respiratory_system1.91048151
20MP0005023_abnormal_wound_healing1.90610595
21MP0002138_abnormal_hepatobiliary_system1.89656399
22MP0003300_gastrointestinal_ulcer1.83427003
23MP0000003_abnormal_adipose_tissue1.76808249
24MP0005248_abnormal_Harderian_gland1.73570167
25MP0010678_abnormal_skin_adnexa1.69375009
26MP0000733_abnormal_muscle_development1.68858738
27MP0002796_impaired_skin_barrier1.67795457
28MP0002060_abnormal_skin_morphology1.66273350
29MP0005076_abnormal_cell_differentiation1.65994161
30MP0005083_abnormal_biliary_tract1.62169827
31MP0000858_altered_metastatic_potential1.59745189
32MP0005501_abnormal_skin_physiology1.57894884
33MP0002909_abnormal_adrenal_gland1.56043991
34MP0002254_reproductive_system_inflammat1.55657818
35MP0000377_abnormal_hair_follicle1.52961831
36MP0003091_abnormal_cell_migration1.52780314
37MP0008875_abnormal_xenobiotic_pharmacok1.47059133
38MP0005058_abnormal_lysosome_morphology1.45268076
39MP0001216_abnormal_epidermal_layer1.44603790
40MP0009384_cardiac_valve_regurgitation1.41630123
41MP0004381_abnormal_hair_follicle1.34661321
42MP0000467_abnormal_esophagus_morphology1.31395613
43MP0001944_abnormal_pancreas_morphology1.31268711
44MP0000627_abnormal_mammary_gland1.30613891
45MP0003045_fibrosis1.30565310
46MP0001958_emphysema1.29403478
47MP0000762_abnormal_tongue_morphology1.29023597
48MP0003119_abnormal_digestive_system1.28657379
49MP0003329_amyloid_beta_deposits1.26137653
50MP0008438_abnormal_cutaneous_collagen1.25819496
51MP0002166_altered_tumor_susceptibility1.24948684
52MP0002896_abnormal_bone_mineralization1.20673311
53MP0000013_abnormal_adipose_tissue1.17195511
54MP0010030_abnormal_orbit_morphology1.15077632
55MP0005375_adipose_tissue_phenotype1.14225540
56MP0008789_abnormal_olfactory_epithelium1.14198893
57MP0004782_abnormal_surfactant_physiolog1.14056256
58MP0003191_abnormal_cellular_cholesterol1.13040566
59MP0006138_congestive_heart_failure1.09836464
60MP0005220_abnormal_exocrine_pancreas1.07631264
61MP0003950_abnormal_plasma_membrane1.07423550
62MP0009053_abnormal_anal_canal1.06817564
63MP0003941_abnormal_skin_development1.05796761
64MP0002168_other_aberrant_phenotype1.03303425
65MP0001881_abnormal_mammary_gland1.01778320
66MP0004947_skin_inflammation1.01452262
67MP0001243_abnormal_dermal_layer1.01107870
68MP0010771_integument_phenotype0.99894184
69MP0005171_absent_coat_pigmentation0.99474115
70MP0009931_abnormal_skin_appearance0.98208301
71MP0003283_abnormal_digestive_organ0.97886704
72MP0002295_abnormal_pulmonary_circulatio0.97384584
73MP0010368_abnormal_lymphatic_system0.96757167
74MP0000462_abnormal_digestive_system0.95548372
75MP0003786_premature_aging0.94832365
76MP0000678_abnormal_parathyroid_gland0.94708141
77MP0002249_abnormal_larynx_morphology0.93854367
78MP0003937_abnormal_limbs/digits/tail_de0.92882607
79MP0001542_abnormal_bone_strength0.91578944
80MP0003890_abnormal_embryonic-extraembry0.91404418
81MP0003942_abnormal_urinary_system0.90308409
82MP0010307_abnormal_tumor_latency0.90255146
83MP0000613_abnormal_salivary_gland0.88331310
84MP0005165_increased_susceptibility_to0.87903641
85MP0002139_abnormal_hepatobiliary_system0.87793913
86MP0000538_abnormal_urinary_bladder0.86809355
87MP0005508_abnormal_skeleton_morphology0.86006290
88MP0010155_abnormal_intestine_physiology0.85159675
89MP0002092_abnormal_eye_morphology0.84997070
90MP0000477_abnormal_intestine_morphology0.81579003
91MP0000383_abnormal_hair_follicle0.80938342
92MP0000534_abnormal_ureter_morphology0.79458436
93MP0005330_cardiomyopathy0.79421498
94MP0002098_abnormal_vibrissa_morphology0.79252327
95MP0000569_abnormal_digit_pigmentation0.79099262
96MP0000750_abnormal_muscle_regeneration0.78628559
97MP0001346_abnormal_lacrimal_gland0.78155697
98MP0005164_abnormal_response_to0.78107113
99MP0000470_abnormal_stomach_morphology0.76932994
100MP0000163_abnormal_cartilage_morphology0.76777540
101MP0002282_abnormal_trachea_morphology0.76319579
102MP0002925_abnormal_cardiovascular_devel0.76261096
103MP0001348_abnormal_lacrimal_gland0.76211744
104MP0008260_abnormal_autophagy0.74774835
105MP0002006_tumorigenesis0.74585249
106MP0000751_myopathy0.74511554
107MP0005167_abnormal_blood-brain_barrier0.74397158
108MP0001191_abnormal_skin_condition0.73780330
109MP0004233_abnormal_muscle_weight0.73458398
110MP0009643_abnormal_urine_homeostasis0.72574648
111MP0004133_heterotaxia0.72260168
112MP0005503_abnormal_tendon_morphology0.71633598
113MP0005666_abnormal_adipose_tissue0.71496784
114MP0005193_abnormal_anterior_eye0.70916844
115MP0005621_abnormal_cell_physiology0.70297659
116MP0002233_abnormal_nose_morphology0.68340925
117MP0005408_hypopigmentation0.68014151
118MP0001286_abnormal_eye_development0.67988046
119MP0001915_intracranial_hemorrhage0.67857171
120MP0000428_abnormal_craniofacial_morphol0.67747788
121MP0000639_abnormal_adrenal_gland0.67487969
122MP0003195_calcinosis0.67443902
123MP0005394_taste/olfaction_phenotype0.67352765
124MP0005499_abnormal_olfactory_system0.67352765
125MP0004858_abnormal_nervous_system0.66592317
126MP0002136_abnormal_kidney_physiology0.65024657
127MP0002933_joint_inflammation0.63804167
128MP0003936_abnormal_reproductive_system0.63149084
129MP0004197_abnormal_fetal_growth/weight/0.62640641
130MP0002086_abnormal_extraembryonic_tissu0.62377696
131MP0004087_abnormal_muscle_fiber0.62217384
132MP0001299_abnormal_eye_distance/0.61893536
133MP0004185_abnormal_adipocyte_glucose0.59429001
134MP0000367_abnormal_coat/_hair0.58991433
135MP0001851_eye_inflammation0.58357187
136MP0004019_abnormal_vitamin_homeostasis0.56965577
137MP0003656_abnormal_erythrocyte_physiolo0.56370708
138MP0002932_abnormal_joint_morphology0.54701719
139MP0005388_respiratory_system_phenotype0.54310856
140MP0002133_abnormal_respiratory_system0.54310856
141MP0001340_abnormal_eyelid_morphology0.52355972
142MP0003075_altered_response_to0.51412299
143MP0002116_abnormal_craniofacial_bone0.49989837
144MP0000249_abnormal_blood_vessel0.47546843

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.44717562
2Onycholysis (HP:0001806)6.14047411
3Atrophic scars (HP:0001075)5.27735921
4Abnormal respiratory motile cilium physiology (HP:0012261)5.25652161
5Abnormal respiratory motile cilium morphology (HP:0005938)5.12592494
6Abnormal respiratory epithelium morphology (HP:0012253)5.12592494
7Rhinitis (HP:0012384)5.07351937
8Milia (HP:0001056)5.03423636
9Abnormal ciliary motility (HP:0012262)4.88619712
10Absent/shortened dynein arms (HP:0200106)4.83549537
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.83549537
12Right ventricular cardiomyopathy (HP:0011663)4.77114167
13Nasal polyposis (HP:0100582)4.30238470
14Interstitial pulmonary disease (HP:0006530)4.28803829
15Fragile nails (HP:0001808)4.07879537
16Micronodular cirrhosis (HP:0001413)4.03918058
17Focal segmental glomerulosclerosis (HP:0000097)3.94781043
18Glomerulosclerosis (HP:0000096)3.83111742
19Bronchiectasis (HP:0002110)3.67397703
20Increased connective tissue (HP:0009025)3.62150223
21Abnormality of the nasal mucosa (HP:0000433)3.58818308
22Pterygium (HP:0001059)3.31426177
23Arterial tortuosity (HP:0005116)3.22653317
24Bronchomalacia (HP:0002780)3.20906416
25Pustule (HP:0200039)3.19766762
26Fragile skin (HP:0001030)3.16797866
27Gout (HP:0001997)3.12838870
28Plantar hyperkeratosis (HP:0007556)3.12505946
29Vascular tortuosity (HP:0004948)3.05677772
30Nail dystrophy (HP:0008404)3.04763351
31Cervical subluxation (HP:0003308)2.96888117
32Subacute progressive viral hepatitis (HP:0006572)2.92169198
33Bowed forearm bones (HP:0003956)2.78987810
34Bowing of the arm (HP:0006488)2.78987810
35Hypoplasia of dental enamel (HP:0006297)2.76926759
36Abnormality of the gastric mucosa (HP:0004295)2.74016249
37Ulnar bowing (HP:0003031)2.73766292
38Short nail (HP:0001799)2.72441366
39Hypotrichosis (HP:0001006)2.72069977
40Flat acetabular roof (HP:0003180)2.66722510
41Chronic bronchitis (HP:0004469)2.63044056
42Fused cervical vertebrae (HP:0002949)2.62466034
43Protrusio acetabuli (HP:0003179)2.59850592
44Cerebral aneurysm (HP:0004944)2.59290691
45Trismus (HP:0000211)2.55503510
46Entropion (HP:0000621)2.55364440
47Pili torti (HP:0003777)2.50898219
48Abnormal blistering of the skin (HP:0008066)2.49503920
49Alopecia of scalp (HP:0002293)2.48934611
50Abnormality of the distal phalanges of the toes (HP:0010182)2.47178111
51Thick nail (HP:0001805)2.46046439
52Esophageal atresia (HP:0002032)2.45956414
53Muscle fiber splitting (HP:0003555)2.42675312
54Vertebral hypoplasia (HP:0008417)2.42445097
55Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.42445097
56Popliteal pterygium (HP:0009756)2.42155362
57Hypoplasia of the iris (HP:0007676)2.38518577
58Bronchitis (HP:0012387)2.37609003
59Atelectasis (HP:0100750)2.36590079
60Premature rupture of membranes (HP:0001788)2.35518576
61Reduced subcutaneous adipose tissue (HP:0003758)2.33678402
62Curly hair (HP:0002212)2.32789911
63Hyperactive renin-angiotensin system (HP:0000841)2.32613953
64Shallow orbits (HP:0000586)2.32311439
65Broad face (HP:0000283)2.32026423
66Lip pit (HP:0100267)2.31790509
67Abnormal hemoglobin (HP:0011902)2.30951242
68Male infertility (HP:0003251)2.29835983
69Rectal prolapse (HP:0002035)2.29780829
70Missing ribs (HP:0000921)2.27643188
71Ankyloglossia (HP:0010296)2.27148429
72Abnormalities of placenta or umbilical cord (HP:0001194)2.26474056
73Radial bowing (HP:0002986)2.26331351
74Aplasia cutis congenita (HP:0001057)2.26267331
75Obstructive sleep apnea (HP:0002870)2.24450781
76Hypoplastic pelvis (HP:0008839)2.22666052
77Abdominal distention (HP:0003270)2.22388339
78Natal tooth (HP:0000695)2.21255778
79Abnormality of oral frenula (HP:0000190)2.20821548
80Dry hair (HP:0011359)2.19367824
81Amniotic constriction ring (HP:0009775)2.14827455
82Abnormality of placental membranes (HP:0011409)2.14827455
83Esophageal varix (HP:0002040)2.13897664
84Down-sloping shoulders (HP:0200021)2.13776879
85Tubular atrophy (HP:0000092)2.10940163
86Aortic aneurysm (HP:0004942)2.09246508
87Renal salt wasting (HP:0000127)2.09047397
88Mildly elevated creatine phosphokinase (HP:0008180)2.08833382
89Abnormality of the neuromuscular junction (HP:0003398)2.08088265
90Fatigable weakness (HP:0003473)2.08088265
91Malnutrition (HP:0004395)2.06900252
92Abnormal auditory evoked potentials (HP:0006958)2.06211942
93Unilateral renal agenesis (HP:0000122)2.04644785
94Advanced eruption of teeth (HP:0006288)2.04097024
95Infertility (HP:0000789)2.03680608
96Abnormality of the calcaneus (HP:0008364)2.00807998
97Abnormality of nail color (HP:0100643)2.00369579
98Upper limb amyotrophy (HP:0009129)1.99657564
99Distal upper limb amyotrophy (HP:0007149)1.99657564
100Back pain (HP:0003418)1.99391514
101Ankle contracture (HP:0006466)1.98420147
102Choroideremia (HP:0001139)1.96451385
103Lymphangioma (HP:0100764)1.96348906
104Vertebral clefting (HP:0008428)1.96287136
105Abnormality of proline metabolism (HP:0010907)1.95506236
106Hydroxyprolinuria (HP:0003080)1.95506236
107Spinal cord compression (HP:0002176)1.95096743
108Hypercortisolism (HP:0001578)1.94165004
109Severe short stature (HP:0003510)1.93433996
110Elbow flexion contracture (HP:0002987)1.93011844
111Synostosis involving the elbow (HP:0003938)1.92719374
112Humeroradial synostosis (HP:0003041)1.92719374
113Fibular aplasia (HP:0002990)1.91762818
114Chronic sinusitis (HP:0011109)1.90954555
115Recurrent otitis media (HP:0000403)1.87150431
116Palmoplantar hyperkeratosis (HP:0000972)1.85028186
117Aneurysm (HP:0002617)1.84986072
118Hand muscle atrophy (HP:0009130)1.83628725
119Poikiloderma (HP:0001029)1.83215546
120Abnormal hair laboratory examination (HP:0003328)1.82632125
121Cone-rod dystrophy (HP:0000548)1.82583827
122Germ cell neoplasia (HP:0100728)1.81613153
123Bell-shaped thorax (HP:0001591)1.81430427
124Glucose intolerance (HP:0000833)1.80232542
12511 pairs of ribs (HP:0000878)1.78890363
126Tarsal synostosis (HP:0008368)1.78394564
127Distal lower limb muscle weakness (HP:0009053)1.77204007
128Ventricular tachycardia (HP:0004756)1.76547202
129Aortic dissection (HP:0002647)1.75882532
130Spinal rigidity (HP:0003306)1.75704279
131Hyperkalemia (HP:0002153)1.75438046
132Biliary tract neoplasm (HP:0100574)1.74805819
133Osteolytic defects of the hand bones (HP:0009699)1.73971298
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.73971298
135Abnormal vertebral ossification (HP:0100569)1.73076690
136Uterine neoplasm (HP:0010784)1.72760705
137Woolly hair (HP:0002224)1.72484937
138Vascular calcification (HP:0004934)1.71908008
139Buphthalmos (HP:0000557)1.71842856
140Cardiovascular calcification (HP:0011915)1.71784288
141Weak cry (HP:0001612)1.71434150
142Decreased lacrimation (HP:0000633)1.70558432
143Ridged nail (HP:0001807)1.70058945
144Distal lower limb amyotrophy (HP:0008944)1.69993029
145Hypoplastic labia majora (HP:0000059)1.68993661
146Scapular winging (HP:0003691)1.68818050
147Spastic diplegia (HP:0001264)1.68359464
148Gastrointestinal atresia (HP:0002589)1.67830821
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66967242
150Palmar hyperkeratosis (HP:0010765)1.63488486
151Ureteral duplication (HP:0000073)1.63212229
152Flattened epiphyses (HP:0003071)1.61705818
153Epiphyseal dysplasia (HP:0002656)1.61425438
154Stridor (HP:0010307)1.61249782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.39781985
2PBK2.81558708
3FRK2.49166658
4PTK22.44101756
5FER2.43347119
6PAK42.38612055
7TRIB32.27659545
8NME22.25158432
9MUSK2.17788623
10EPHA210.2030322
11PIM21.99843209
12MST1R1.97762343
13NME11.96629741
14ERBB31.95782733
15TTN1.91115863
16PTK61.89000205
17MAP3K21.73261748
18LRRK21.72763903
19EPHB21.71830428
20PKN21.69598738
21TRPM71.67701377
22SMG11.66068185
23MAP3K61.64735424
24RPS6KB21.62612182
25LATS11.52939676
26MET1.51484240
27STK101.47553083
28MAP2K21.41181760
29PDGFRA1.38817247
30DYRK1B1.35254489
31MAP3K121.33168784
32RIPK11.32615842
33ERN11.32580008
34STK241.30405776
35TGFBR21.29113911
36TESK11.25618682
37DDR21.24875098
38MAP3K31.23953891
39MAP2K11.20290346
40PAK31.13567457
41EEF2K1.08951735
42STK381.08279209
43EPHB11.06343758
44PASK1.01005900
45PRKCI0.94191896
46NTRK10.93299986
47MAPK150.90190208
48PDK20.87091906
49NEK90.84915584
50FLT30.81159216
51ICK0.80052419
52STK38L0.79824608
53BMX0.79565571
54LIMK10.78094490
55SCYL20.77012398
56PAK20.76731175
57CHUK0.76414507
58CDK60.75423446
59PDGFRB0.73715410
60MARK20.73504582
61DAPK10.72060317
62STK30.71856972
63IRAK30.71807034
64PRKG20.70160640
65RPS6KA40.68956141
66NEK60.66917972
67RPS6KA20.65647107
68ILK0.64717699
69MAPKAPK30.58887000
70TGFBR10.57706480
71FGFR40.56782101
72BCR0.56623319
73CDK80.56390626
74ROCK20.55536155
75MAP3K80.53940345
76MAP3K140.53908243
77MTOR0.53689132
78CDC42BPA0.52985025
79FGFR10.49293286
80PRKD30.49198733
81EGFR0.48605974
82PRKD20.46785125
83DAPK30.45585922
84ERBB40.44454152
85CDK120.43842377
86CSK0.42620171
87ERBB20.42123338
88WNK10.41479859
89SIK10.41452176
90PDPK10.41121366
91SIK30.40998595
92MELK0.40199620
93ZAP700.39820806
94SRC0.39327256
95MAP3K70.39020689
96PTK2B0.38954248
97MAP3K90.38019272
98MAP3K100.37791148
99HIPK20.37734563
100DMPK0.37102536
101MOS0.36882689
102ABL20.35606301
103TBK10.35588122
104CAMK2D0.34118617
105ABL10.34033182
106MAPKAPK20.33891114
107INSR0.33849618
108ROCK10.33363392
109MYLK0.32064131
110PRPF4B0.31760390
111RPS6KL10.31276791
112RPS6KC10.31276791
113LATS20.31074948
114CAMK2B0.30935347
115GSK3A0.30883516
116CSNK1A1L0.28655239
117TTK0.25964396
118PRKD10.25626582
119MAPK110.24642844
120EPHA40.23369518
121IGF1R0.23125000
122KSR20.22543441
123LMTK20.22269424
124NEK20.21392541
125CAMK2G0.20726317
126PRKCE0.20679560
127MAPKAPK50.19679456
128EPHA30.19642905
129AKT20.19417326
130AURKB0.18573707
131RPS6KA60.18474972
132MAP3K10.17656467
133ARAF0.17529106
134RPS6KA10.16343784
135NUAK10.16065863
136MATK0.15850361

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.29750136
2Bladder cancer_Homo sapiens_hsa052192.95705451
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.94189057
4Small cell lung cancer_Homo sapiens_hsa052222.93169890
5Adherens junction_Homo sapiens_hsa045202.90978182
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.79824152
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.58121710
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.39575810
9Notch signaling pathway_Homo sapiens_hsa043302.38547280
10Focal adhesion_Homo sapiens_hsa045102.37207292
11Tight junction_Homo sapiens_hsa045302.33146347
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.20682222
13Proteoglycans in cancer_Homo sapiens_hsa052052.18625579
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12956477
15Leukocyte transendothelial migration_Homo sapiens_hsa046702.08610269
16Hippo signaling pathway_Homo sapiens_hsa043902.01440480
17Thyroid cancer_Homo sapiens_hsa052161.83181444
18Galactose metabolism_Homo sapiens_hsa000521.78200593
19Other glycan degradation_Homo sapiens_hsa005111.76754982
20Chronic myeloid leukemia_Homo sapiens_hsa052201.76492430
21Amoebiasis_Homo sapiens_hsa051461.70859671
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68104342
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61015718
24Sulfur metabolism_Homo sapiens_hsa009201.60131613
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58586431
26p53 signaling pathway_Homo sapiens_hsa041151.54298475
27Dilated cardiomyopathy_Homo sapiens_hsa054141.54026859
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46842233
29Glutathione metabolism_Homo sapiens_hsa004801.45789879
30Shigellosis_Homo sapiens_hsa051311.43137655
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43108216
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42858524
33Toxoplasmosis_Homo sapiens_hsa051451.41066442
34Arginine biosynthesis_Homo sapiens_hsa002201.40929111
35Sphingolipid metabolism_Homo sapiens_hsa006001.38883346
36Pancreatic cancer_Homo sapiens_hsa052121.32788966
37Phenylalanine metabolism_Homo sapiens_hsa003601.31349351
38Fructose and mannose metabolism_Homo sapiens_hsa000511.30582788
39Chemical carcinogenesis_Homo sapiens_hsa052041.26784154
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26400822
41Vibrio cholerae infection_Homo sapiens_hsa051101.26073511
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.21694466
43Endometrial cancer_Homo sapiens_hsa052131.20236322
44Pentose phosphate pathway_Homo sapiens_hsa000301.20011604
45Viral myocarditis_Homo sapiens_hsa054161.18749214
46MicroRNAs in cancer_Homo sapiens_hsa052061.17051102
47Protein export_Homo sapiens_hsa030601.06405249
48Hematopoietic cell lineage_Homo sapiens_hsa046401.06043500
49TNF signaling pathway_Homo sapiens_hsa046681.05643326
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05036695
51Melanoma_Homo sapiens_hsa052181.04662268
52TGF-beta signaling pathway_Homo sapiens_hsa043501.04298075
53Pathways in cancer_Homo sapiens_hsa052001.01566582
54Salmonella infection_Homo sapiens_hsa051320.99835421
55Basal cell carcinoma_Homo sapiens_hsa052170.95979533
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94337496
57N-Glycan biosynthesis_Homo sapiens_hsa005100.91257123
58Biosynthesis of amino acids_Homo sapiens_hsa012300.87584432
59Apoptosis_Homo sapiens_hsa042100.86924841
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86650137
61Colorectal cancer_Homo sapiens_hsa052100.85361274
62Hedgehog signaling pathway_Homo sapiens_hsa043400.85356300
63Glioma_Homo sapiens_hsa052140.84624697
64Circadian rhythm_Homo sapiens_hsa047100.84558143
65beta-Alanine metabolism_Homo sapiens_hsa004100.83242573
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79217257
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77813213
68Rap1 signaling pathway_Homo sapiens_hsa040150.77392957
69Prostate cancer_Homo sapiens_hsa052150.77079829
70Legionellosis_Homo sapiens_hsa051340.76001145
71Tyrosine metabolism_Homo sapiens_hsa003500.75585843
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75016398
73ABC transporters_Homo sapiens_hsa020100.74868577
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74854886
75Complement and coagulation cascades_Homo sapiens_hsa046100.74006872
76Choline metabolism in cancer_Homo sapiens_hsa052310.73154462
77Thyroid hormone synthesis_Homo sapiens_hsa049180.70713064
78Malaria_Homo sapiens_hsa051440.70523107
79Renal cell carcinoma_Homo sapiens_hsa052110.68123412
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.67200772
81Hepatitis C_Homo sapiens_hsa051600.66942863
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66452756
83Insulin signaling pathway_Homo sapiens_hsa049100.66341664
84Prolactin signaling pathway_Homo sapiens_hsa049170.66065419
85Pertussis_Homo sapiens_hsa051330.65866881
86Viral carcinogenesis_Homo sapiens_hsa052030.65233156
87Protein digestion and absorption_Homo sapiens_hsa049740.62886319
88Endocytosis_Homo sapiens_hsa041440.60898644
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60262209
90HTLV-I infection_Homo sapiens_hsa051660.60040355
91Platelet activation_Homo sapiens_hsa046110.58011744
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56608757
93VEGF signaling pathway_Homo sapiens_hsa043700.54921353
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.54582386
95FoxO signaling pathway_Homo sapiens_hsa040680.54398363
96Inositol phosphate metabolism_Homo sapiens_hsa005620.52244184
97Axon guidance_Homo sapiens_hsa043600.51905068
98Histidine metabolism_Homo sapiens_hsa003400.51700437
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51427638
100Wnt signaling pathway_Homo sapiens_hsa043100.51336722
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50619435
102Retinol metabolism_Homo sapiens_hsa008300.50177554
103Estrogen signaling pathway_Homo sapiens_hsa049150.49174182
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48577106
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47827540
106Leishmaniasis_Homo sapiens_hsa051400.47569165
107Phagosome_Homo sapiens_hsa041450.46746311
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46643471
109Starch and sucrose metabolism_Homo sapiens_hsa005000.45458403
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44672473
111Lysosome_Homo sapiens_hsa041420.44452121
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44332416
113ErbB signaling pathway_Homo sapiens_hsa040120.43281605
114Sulfur relay system_Homo sapiens_hsa041220.43262739
115Non-small cell lung cancer_Homo sapiens_hsa052230.42984148
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42806521
117Melanogenesis_Homo sapiens_hsa049160.41602535
118Glucagon signaling pathway_Homo sapiens_hsa049220.41369503
119Influenza A_Homo sapiens_hsa051640.40556949
120Nucleotide excision repair_Homo sapiens_hsa034200.39741923
121Hepatitis B_Homo sapiens_hsa051610.39650516
122Acute myeloid leukemia_Homo sapiens_hsa052210.39101827
123HIF-1 signaling pathway_Homo sapiens_hsa040660.38781588
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.36595794
125mTOR signaling pathway_Homo sapiens_hsa041500.31895262
126Insulin resistance_Homo sapiens_hsa049310.30453603
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29974177
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.28757868
129Fatty acid degradation_Homo sapiens_hsa000710.27701655
130GnRH signaling pathway_Homo sapiens_hsa049120.26955715
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.26228878
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.24961483
133Antigen processing and presentation_Homo sapiens_hsa046120.24005995

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