MSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.33830486
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.33830486
3modulation by symbiont of host immune response (GO:0052553)5.33830486
4positive regulation by symbiont of host defense response (GO:0052509)5.33830486
5modulation by symbiont of host defense response (GO:0052031)5.33830486
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.33830486
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97875101
8detection of molecule of bacterial origin (GO:0032490)4.71075334
9positive regulation of gamma-delta T cell activation (GO:0046645)4.63737712
10macrophage activation involved in immune response (GO:0002281)4.35112649
11locomotory exploration behavior (GO:0035641)4.31701835
12detection of other organism (GO:0098543)4.30988817
13dendritic spine morphogenesis (GO:0060997)4.17376412
14layer formation in cerebral cortex (GO:0021819)4.15569706
15detection of external biotic stimulus (GO:0098581)4.10488732
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06130865
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05958470
18synaptic vesicle maturation (GO:0016188)4.04780691
19negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.03289404
20detection of bacterium (GO:0016045)3.92629384
21leukocyte migration involved in inflammatory response (GO:0002523)3.86663964
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83199864
23antigen processing and presentation of endogenous antigen (GO:0019883)3.81937286
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80489122
25histone H3-K36 demethylation (GO:0070544)3.79490683
26cellular extravasation (GO:0045123)3.77956644
27regulation of B cell receptor signaling pathway (GO:0050855)3.77616392
28leukocyte aggregation (GO:0070486)3.68924617
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.68214033
30response to peptidoglycan (GO:0032494)3.67370241
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.67369486
32negative regulation of erythrocyte differentiation (GO:0045647)3.64303372
33regulation of interferon-beta biosynthetic process (GO:0045357)3.62634589
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60607807
35regulation of gamma-delta T cell activation (GO:0046643)3.59210434
36detection of biotic stimulus (GO:0009595)3.58840257
37response to interleukin-15 (GO:0070672)3.57070794
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.52541528
39vocalization behavior (GO:0071625)3.47506511
40microglial cell activation (GO:0001774)3.47202192
41response to host immune response (GO:0052572)3.46940585
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46940585
43histone H3-K9 demethylation (GO:0033169)3.43581491
44neuron cell-cell adhesion (GO:0007158)3.36545128
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.34318743
46response to host (GO:0075136)3.34318743
47response to host defenses (GO:0052200)3.34318743
48dendrite morphogenesis (GO:0048813)3.32256780
49neutrophil activation involved in immune response (GO:0002283)3.32172441
50regulation of gamma-delta T cell differentiation (GO:0045586)3.28471649
51response to muramyl dipeptide (GO:0032495)3.28034941
52presynaptic membrane organization (GO:0097090)3.25708280
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.21636215
54regulation of glutamate receptor signaling pathway (GO:1900449)3.20273705
55macrophage activation (GO:0042116)3.18021918
56neuron recognition (GO:0008038)3.17889384
57negative regulation of leukocyte mediated immunity (GO:0002704)3.15286438
58presynaptic membrane assembly (GO:0097105)3.15185613
59regulation of T-helper 2 cell differentiation (GO:0045628)3.14785122
60exploration behavior (GO:0035640)3.13156865
61synaptic vesicle exocytosis (GO:0016079)3.11851860
62regulation of synaptic vesicle exocytosis (GO:2000300)3.09735578
63axonal fasciculation (GO:0007413)3.03155403
64neutrophil mediated immunity (GO:0002446)3.01463603
65neutrophil activation (GO:0042119)2.97699874
66cellular response to interleukin-15 (GO:0071350)2.97552143
67central nervous system projection neuron axonogenesis (GO:0021952)2.96399580
68glutamate secretion (GO:0014047)2.96364478
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95947636
70regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95569118
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95091843
72regulation of synapse structural plasticity (GO:0051823)2.93928067
73nerve growth factor signaling pathway (GO:0038180)2.93664768
74negative regulation of T cell mediated immunity (GO:0002710)2.92832353
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.91475768
76histone lysine demethylation (GO:0070076)2.91340417
77negative regulation of type 2 immune response (GO:0002829)2.90908785
78regulation of neuronal synaptic plasticity (GO:0048168)2.90739319
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89189081
80establishment of nucleus localization (GO:0040023)2.88676579
81cell migration in hindbrain (GO:0021535)2.88034834
82neuronal ion channel clustering (GO:0045161)2.87511412
83protein localization to synapse (GO:0035418)2.85974039
84activated T cell proliferation (GO:0050798)2.84716478
85respiratory burst (GO:0045730)2.82455222
86auditory behavior (GO:0031223)2.81519995
87B cell receptor signaling pathway (GO:0050853)2.80998788
88regulation of dendritic spine morphogenesis (GO:0061001)2.80802335
89signal complex assembly (GO:0007172)2.79956172
90glutamate receptor signaling pathway (GO:0007215)2.79622799
91negative regulation of interleukin-12 production (GO:0032695)2.78288882
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77567454
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77213604
94production of molecular mediator involved in inflammatory response (GO:0002532)2.76618745
95histone demethylation (GO:0016577)2.76354140
96regulation of mast cell degranulation (GO:0043304)2.75117687
97regulation of leukocyte degranulation (GO:0043300)2.74149827
98antigen processing and presentation via MHC class Ib (GO:0002475)2.73454431
99cytoskeletal anchoring at plasma membrane (GO:0007016)2.73174282
100prepulse inhibition (GO:0060134)2.72374103
101negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71904517
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68909748
103regulation of ARF protein signal transduction (GO:0032012)2.68192209
104neuronal action potential propagation (GO:0019227)2.67432094
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.66553151
106mating behavior (GO:0007617)2.65391698
107neurotransmitter secretion (GO:0007269)2.64630030
108dendritic spine organization (GO:0097061)2.64599435
109regulation of ARF GTPase activity (GO:0032312)2.64365296
110peptidyl-tyrosine autophosphorylation (GO:0038083)2.64036657
111regulation of regulated secretory pathway (GO:1903305)2.63892027
112sodium ion export (GO:0071436)2.63891680
113myeloid leukocyte mediated immunity (GO:0002444)2.63400965
114transmission of nerve impulse (GO:0019226)2.63216246
115neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.63179232
116positive regulation of cellular amide metabolic process (GO:0034250)2.62971029
117activation of protein kinase A activity (GO:0034199)2.62611199
118protein targeting to Golgi (GO:0000042)2.62289190
119negative regulation of immunoglobulin mediated immune response (GO:0002890)2.62252813
120negative regulation of B cell mediated immunity (GO:0002713)2.62252813
121negative thymic T cell selection (GO:0045060)2.62006592
122cerebellar Purkinje cell differentiation (GO:0021702)2.58826896
123retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58683440
124myeloid cell activation involved in immune response (GO:0002275)2.57567838
125negative regulation of cAMP-mediated signaling (GO:0043951)2.55752474
126axon ensheathment in central nervous system (GO:0032291)2.55656781
127central nervous system myelination (GO:0022010)2.55656781
128granulocyte activation (GO:0036230)2.55627564
129negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55611588
130synaptic transmission, glutamatergic (GO:0035249)2.54950365
131regulation of synaptic vesicle transport (GO:1902803)2.54755802
132cellular potassium ion homeostasis (GO:0030007)2.54475342
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53643079
134negative regulation of T-helper cell differentiation (GO:0045623)2.53141957
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.53141957
136regulation of mast cell activation involved in immune response (GO:0033006)2.51997697
137germinal center formation (GO:0002467)2.51819704
138regulation of macrophage cytokine production (GO:0010935)2.51637790
139cytoplasmic mRNA processing body assembly (GO:0033962)2.51109528
140long-term memory (GO:0007616)2.47836535
141negative T cell selection (GO:0043383)2.47728665
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47150507
143L-amino acid import (GO:0043092)2.46384109
144regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46332341
145membrane depolarization during action potential (GO:0086010)2.45754977
146central nervous system neuron axonogenesis (GO:0021955)2.45666803
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45537803
148regulation of dendritic spine development (GO:0060998)2.44940914
149clathrin coat assembly (GO:0048268)2.44761283
150I-kappaB phosphorylation (GO:0007252)2.44640271
151neuromuscular process controlling balance (GO:0050885)2.44009346
152suckling behavior (GO:0001967)2.43184227
153establishment of protein localization to Golgi (GO:0072600)2.42595643
154histone H3-K4 trimethylation (GO:0080182)2.41991022
155positive thymic T cell selection (GO:0045059)2.40124099
156negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.39501880
157regulation of NFAT protein import into nucleus (GO:0051532)2.39349059
158neuron-neuron synaptic transmission (GO:0007270)2.38865580
159response to laminar fluid shear stress (GO:0034616)2.38299471
160regulation of postsynaptic membrane potential (GO:0060078)2.37598290
161regulation of Rap GTPase activity (GO:0032317)2.37056523
162negative regulation of axonogenesis (GO:0050771)2.36696274
163regulation of clathrin-mediated endocytosis (GO:2000369)2.36164333
164protein localization to endosome (GO:0036010)2.35942748
165regulation of tolerance induction (GO:0002643)2.35629576
166negative regulation of neurotransmitter transport (GO:0051589)2.35466084
167potassium ion import (GO:0010107)2.34899851
168regulation of amyloid precursor protein catabolic process (GO:1902991)2.34557929
169peptidyl-threonine phosphorylation (GO:0018107)2.34512615
170proline transport (GO:0015824)2.34262176
171synapse organization (GO:0050808)2.33951336
172positive regulation of membrane potential (GO:0045838)2.32833793
173protein dealkylation (GO:0008214)2.32017256
174protein demethylation (GO:0006482)2.32017256
175positive regulation of Rap GTPase activity (GO:0032854)2.31833415
176negative regulation of granulocyte differentiation (GO:0030853)2.31557009
177regulation of axon extension involved in axon guidance (GO:0048841)2.31545667
178neuron projection morphogenesis (GO:0048812)2.31102645
179camera-type eye morphogenesis (GO:0048593)2.30806354
180membrane depolarization (GO:0051899)2.30635920
181vesicle transport along microtubule (GO:0047496)2.30260775
182mechanosensory behavior (GO:0007638)2.30160341
183gamma-aminobutyric acid transport (GO:0015812)2.30156025
184regulation of B cell differentiation (GO:0045577)2.29506659
185gamma-aminobutyric acid signaling pathway (GO:0007214)2.29309941
186negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.29216356
187negative regulation of cell killing (GO:0031342)2.29216356
188regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.28519832
189negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.27316475
190negative regulation of neurotransmitter secretion (GO:0046929)2.27284256
191regulation of synaptic plasticity (GO:0048167)2.27195194
192positive T cell selection (GO:0043368)2.27086988
193cell communication by electrical coupling (GO:0010644)2.26978292
194cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26756017
195response to auditory stimulus (GO:0010996)2.26357543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04492876
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05238666
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88790013
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73486559
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64517529
6TCF7_22412390_ChIP-Seq_EML_Mouse2.60234307
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.56145709
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55464183
9VDR_21846776_ChIP-Seq_THP-1_Human2.51578491
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47684005
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47407264
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43477026
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43477026
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40306408
15MYC_22102868_ChIP-Seq_BL_Human2.32760225
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31576994
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.26377956
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22851381
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20846296
20VDR_24763502_ChIP-Seq_THP-1_Human2.19899181
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18551906
22DROSHA_22980978_ChIP-Seq_HELA_Human2.18509845
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.18434268
24GBX2_23144817_ChIP-Seq_PC3_Human2.17308098
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15923381
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.15897797
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15368113
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13370027
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11653343
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11627932
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.10960893
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.08345533
33RUNX_20019798_ChIP-Seq_JUKART_Human2.07444511
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07406202
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05595318
36SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02886702
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02606838
38IRF8_22096565_ChIP-ChIP_GC-B_Human2.02258596
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.99000190
40* RARB_27405468_Chip-Seq_BRAIN_Mouse1.97846135
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.96206044
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90955020
43SPI1_23127762_ChIP-Seq_K562_Human1.90689931
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88407201
45MAF_26560356_Chip-Seq_TH1_Human1.86938083
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84760109
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.84608234
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.73387827
49* REST_21632747_ChIP-Seq_MESCs_Mouse1.73002342
50UTX_26944678_Chip-Seq_JUKART_Human1.71815709
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71492302
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67431553
53AR_21572438_ChIP-Seq_LNCaP_Human1.62901012
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62601246
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60220787
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54065712
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53573993
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52840284
59ZNF274_21170338_ChIP-Seq_K562_Hela1.51661258
60* SPI1_23547873_ChIP-Seq_NB4_Human1.46086802
61VDR_24787735_ChIP-Seq_THP-1_Human1.45750365
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44956637
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44697385
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44392668
65MAF_26560356_Chip-Seq_TH2_Human1.43912614
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42431889
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.41751188
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41528653
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40330667
70KDM2B_26808549_Chip-Seq_K562_Human1.39566121
71MYB_26560356_Chip-Seq_TH1_Human1.39512311
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39277879
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.34860554
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33466692
75SCL_19346495_ChIP-Seq_HPC-7_Human1.32921612
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32797622
77MYB_26560356_Chip-Seq_TH2_Human1.32122960
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32121267
79TAF15_26573619_Chip-Seq_HEK293_Human1.31146151
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.30249431
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29401828
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.29359702
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29227070
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29097912
85LXR_22292898_ChIP-Seq_THP-1_Human1.28865673
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27590567
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26850372
88SMAD4_21799915_ChIP-Seq_A2780_Human1.26555850
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24874157
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24695158
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.24555627
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24417469
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.23359441
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22316543
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21168198
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20809487
97AHR_22903824_ChIP-Seq_MCF-7_Human1.18719620
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18624550
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.17878815
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17790323
101* PU_27001747_Chip-Seq_BMDM_Mouse1.17433999
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.17420444
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.17158317
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12875646
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.11411202
106* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11106867
107KDM2B_26808549_Chip-Seq_DND41_Human1.10766008
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.10212236
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.10209778
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10005615
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09870134
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09378049
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09121565
114AR_19668381_ChIP-Seq_PC3_Human1.08571204
115TP53_16413492_ChIP-PET_HCT116_Human1.08114296
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07704105
117* ISL1_27105846_Chip-Seq_CPCs_Mouse1.06706493
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05238451
119P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03772693
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03564840
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03114212
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03070516
123* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02620699
124STAT3_23295773_ChIP-Seq_U87_Human1.02429915
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02159088
126SMAD_19615063_ChIP-ChIP_OVARY_Human1.00792083
127GATA3_27048872_Chip-Seq_THYMUS_Human1.00696171
128FOXO3_23340844_ChIP-Seq_DLD1_Human1.00254305
129DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00248347
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00231908
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00126510
132RUNX1_27514584_Chip-Seq_MCF-7_Human1.00109117
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00099818
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.98647735
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.98381506
136* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97683865
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97198177
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.96943775
139P300_19829295_ChIP-Seq_ESCs_Human0.96349482
140* TCF4_23295773_ChIP-Seq_U87_Human0.96281491
141GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95488998
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95457312
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95457312
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95226510
145RNF2_27304074_Chip-Seq_NSC_Mouse0.94701936
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94526485
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93400603
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91827209
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91801177
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91399205
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.91171671
152BCAT_22108803_ChIP-Seq_LS180_Human0.91132791
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.91103485
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90406176
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.90343329
156GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89881861
157CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89550202
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89512156
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89236704
160CREB1_26743006_Chip-Seq_LNCaP_Human0.89108176
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88917827
162AR_25329375_ChIP-Seq_VCAP_Human0.87793451
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.87677379
164NCOR1_26117541_ChIP-Seq_K562_Human0.87049757
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86446792
166SMC4_20622854_ChIP-Seq_HELA_Human0.85449449
167STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85251079
168SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84868050
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84644558
170PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84478366
171IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84033823
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83148281
173CLOCK_20551151_ChIP-Seq_293T_Human0.82109608
174GATA1_19941826_ChIP-Seq_K562_Human0.82054043
175CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81841269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.23521542
2MP0003724_increased_susceptibility_to4.65650434
3MP0003880_abnormal_central_pattern3.67031454
4MP0004270_analgesia3.52919372
5MP0003436_decreased_susceptibility_to3.40670774
6MP0003635_abnormal_synaptic_transmissio3.40333142
7MP0002063_abnormal_learning/memory/cond2.54809499
8MP0003300_gastrointestinal_ulcer2.50384784
9MP0009745_abnormal_behavioral_response2.48417380
10MP0003705_abnormal_hypodermis_morpholog2.47100550
11MP0002064_seizures2.44771450
12MP0003191_abnormal_cellular_cholesterol2.43147655
13MP0002419_abnormal_innate_immunity2.35447804
14MP0002396_abnormal_hematopoietic_system2.31517437
15MP0008260_abnormal_autophagy2.27071026
16MP0000778_abnormal_nervous_system2.24370474
17MP0001486_abnormal_startle_reflex2.21743660
18MP0009046_muscle_twitch2.20344559
19MP0004885_abnormal_endolymph2.20026975
20MP0003183_abnormal_peptide_metabolism2.18116865
21MP0002572_abnormal_emotion/affect_behav2.12953298
22MP0002132_abnormal_respiratory_system2.11380316
23MP0002822_catalepsy2.10370246
24MP0001800_abnormal_humoral_immune2.09618578
25MP0003828_pulmonary_edema2.06374371
26MP0005423_abnormal_somatic_nervous2.05927272
27MP0001835_abnormal_antigen_presentation2.05652310
28MP0005025_abnormal_response_to2.04650962
29MP0009780_abnormal_chondrocyte_physiolo2.04149582
30MP0003122_maternal_imprinting1.98253376
31MP0005409_darkened_coat_color1.97000387
32MP0005076_abnormal_cell_differentiation1.91868561
33MP0000685_abnormal_immune_system1.91440870
34MP0003172_abnormal_lysosome_physiology1.89704177
35MP0009278_abnormal_bone_marrow1.88675181
36MP0002272_abnormal_nervous_system1.87923598
37MP0000569_abnormal_digit_pigmentation1.87689513
38MP0003763_abnormal_thymus_physiology1.85760559
39MP0004381_abnormal_hair_follicle1.84704012
40MP0002734_abnormal_mechanical_nocicepti1.84044349
41MP0002420_abnormal_adaptive_immunity1.83506263
42MP0001819_abnormal_immune_cell1.80669205
43MP0002009_preneoplasia1.79548277
44MP0002723_abnormal_immune_serum1.75345550
45MP0001790_abnormal_immune_system1.68920525
46MP0005387_immune_system_phenotype1.68920525
47MP0005000_abnormal_immune_tolerance1.68583849
48MP0008569_lethality_at_weaning1.67397898
49MP0004264_abnormal_extraembryonic_tissu1.66777383
50MP0000920_abnormal_myelination1.65111561
51MP0001968_abnormal_touch/_nociception1.63576386
52MP0005451_abnormal_body_composition1.63381384
53MP0002184_abnormal_innervation1.63112042
54MP0004145_abnormal_muscle_electrophysio1.62721940
55MP0004811_abnormal_neuron_physiology1.61398295
56MP0000955_abnormal_spinal_cord1.59405897
57MP0002405_respiratory_system_inflammati1.56115533
58MP0002452_abnormal_antigen_presenting1.55667286
59MP0000703_abnormal_thymus_morphology1.54619356
60MP0001533_abnormal_skeleton_physiology1.54031169
61MP0001440_abnormal_grooming_behavior1.53435593
62MP0002557_abnormal_social/conspecific_i1.52189848
63MP0002398_abnormal_bone_marrow1.50284015
64MP0005410_abnormal_fertilization1.47730212
65MP0009785_altered_susceptibility_to1.47384276
66MP0000858_altered_metastatic_potential1.47206950
67MP0005248_abnormal_Harderian_gland1.43885664
68MP0005187_abnormal_penis_morphology1.43853331
69MP0002067_abnormal_sensory_capabilities1.41024085
70MP0004883_abnormal_blood_vessel1.40319490
71MP0003303_peritoneal_inflammation1.39865095
72MP0000716_abnormal_immune_system1.38691455
73MP0003329_amyloid_beta_deposits1.38538233
74MP0002733_abnormal_thermal_nociception1.36958785
75MP0002882_abnormal_neuron_morphology1.36508306
76MP0003787_abnormal_imprinting1.35257100
77MP0004947_skin_inflammation1.34624958
78MP0000751_myopathy1.34485222
79MP0002909_abnormal_adrenal_gland1.33883370
80MP0005671_abnormal_response_to1.33865432
81MP0001958_emphysema1.32727243
82MP0005386_behavior/neurological_phenoty1.31795448
83MP0004924_abnormal_behavior1.31795448
84MP0002277_abnormal_respiratory_mucosa1.31458982
85MP0001851_eye_inflammation1.30342970
86MP0001970_abnormal_pain_threshold1.30118469
87MP0004808_abnormal_hematopoietic_stem1.28709708
88MP0005623_abnormal_meninges_morphology1.28650667
89MP0003866_abnormal_defecation1.27852946
90MP0002152_abnormal_brain_morphology1.26788140
91MP0003385_abnormal_body_wall1.25676741
92MP0001299_abnormal_eye_distance/1.25215419
93MP0010155_abnormal_intestine_physiology1.25087745
94MP0001501_abnormal_sleep_pattern1.22899077
95MP0003091_abnormal_cell_migration1.20066903
96MP0003123_paternal_imprinting1.19725055
97MP0002166_altered_tumor_susceptibility1.16734909
98MP0002722_abnormal_immune_system1.16294097
99MP0004858_abnormal_nervous_system1.15975545
100MP0002066_abnormal_motor_capabilities/c1.14682505
101MP0003633_abnormal_nervous_system1.13546215
102MP0004742_abnormal_vestibular_system1.10077988
103MP0000537_abnormal_urethra_morphology1.09775045
104MP0002998_abnormal_bone_remodeling1.09731018
105MP0006082_CNS_inflammation1.08794421
106MP0004185_abnormal_adipocyte_glucose1.07211738
107MP0000534_abnormal_ureter_morphology1.07190495
108MP0002877_abnormal_melanocyte_morpholog1.06915788
109MP0000678_abnormal_parathyroid_gland1.06640064
110MP0003634_abnormal_glial_cell1.06280644
111MP0002234_abnormal_pharynx_morphology1.05866815
112MP0008877_abnormal_DNA_methylation1.04596645
113MP0005388_respiratory_system_phenotype1.02930962
114MP0002133_abnormal_respiratory_system1.02930962
115MP0008961_abnormal_basal_metabolism1.02635955
116MP0005464_abnormal_platelet_physiology1.00877403
117MP0004085_abnormal_heartbeat1.00814270
118MP0002429_abnormal_blood_cell1.00761659
119MP0003115_abnormal_respiratory_system1.00267203
120MP0003861_abnormal_nervous_system0.99575599
121MP0001984_abnormal_olfaction0.97740325
122MP0000689_abnormal_spleen_morphology0.97134022
123MP0002735_abnormal_chemical_nociception0.96826626
124MP0002249_abnormal_larynx_morphology0.96805944
125MP0003631_nervous_system_phenotype0.94851547
126MP0010234_abnormal_vibrissa_follicle0.94358216
127MP0004130_abnormal_muscle_cell0.93227856
128MP0002837_dystrophic_cardiac_calcinosis0.92636502
129MP0003690_abnormal_glial_cell0.92293119
130MP0000747_muscle_weakness0.91898857
131MP0001845_abnormal_inflammatory_respons0.90148530
132MP0003045_fibrosis0.88989052
133MP0002736_abnormal_nociception_after0.88825290
134MP0003943_abnormal_hepatobiliary_system0.88539335
135MP0004233_abnormal_muscle_weight0.88142277
136MP0001905_abnormal_dopamine_level0.87958880
137MP0001915_intracranial_hemorrhage0.87476163
138MP0005310_abnormal_salivary_gland0.86562145
139MP0001849_ear_inflammation0.86103169
140MP0000428_abnormal_craniofacial_morphol0.85964184
141MP0000631_abnormal_neuroendocrine_gland0.85698172
142MP0010630_abnormal_cardiac_muscle0.84522915
143MP0005164_abnormal_response_to0.83631342
144MP0001485_abnormal_pinna_reflex0.82988362
145MP0008874_decreased_physiological_sensi0.81455935
146MP0005397_hematopoietic_system_phenotyp0.79314693
147MP0001545_abnormal_hematopoietic_system0.79314693
148MP0009250_abnormal_appendicular_skeleto0.78383751
149MP0003938_abnormal_ear_development0.78257939
150MP0003632_abnormal_nervous_system0.77849048
151MP0001943_abnormal_respiration0.76659296
152MP0003942_abnormal_urinary_system0.75770621
153MP0008057_abnormal_DNA_replication0.75347213
154MP0000733_abnormal_muscle_development0.74776995
155MP0003121_genomic_imprinting0.74593599
156MP0004134_abnormal_chest_morphology0.74549145
157MP0000003_abnormal_adipose_tissue0.74537654
158MP0003935_abnormal_craniofacial_develop0.73491908
159MP0004087_abnormal_muscle_fiber0.73467608
160MP0004484_altered_response_of0.72151510
161MP0003221_abnormal_cardiomyocyte_apopto0.71593615
162MP0009053_abnormal_anal_canal0.71340428
163MP0003448_altered_tumor_morphology0.69871593
164MP0002089_abnormal_postnatal_growth/wei0.69812764
165MP0002752_abnormal_somatic_nervous0.69610602
166MP0001340_abnormal_eyelid_morphology0.69435415
167MP0005666_abnormal_adipose_tissue0.69239512
168MP0002081_perinatal_lethality0.69070001
169MP0002971_abnormal_brown_adipose0.68936589
170MP0002229_neurodegeneration0.68905882
171MP0001502_abnormal_circadian_rhythm0.68197185
172MP0002925_abnormal_cardiovascular_devel0.67356466
173MP0005645_abnormal_hypothalamus_physiol0.66921693
174MP0001177_atelectasis0.65716412
175MP0003453_abnormal_keratinocyte_physiol0.65694304
176MP0005390_skeleton_phenotype0.65476230
177MP0002069_abnormal_eating/drinking_beha0.65122388
178MP0006276_abnormal_autonomic_nervous0.64765567
179MP0000767_abnormal_smooth_muscle0.64643665
180MP0003698_abnormal_male_reproductive0.64447768
181MP0003137_abnormal_impulse_conducting0.64107840
182MP0010678_abnormal_skin_adnexa0.63416488
183MP0001175_abnormal_lung_morphology0.63338914
184MP0002928_abnormal_bile_duct0.63238378

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.03347007
2Recurrent bacterial skin infections (HP:0005406)4.19134925
3Recurrent abscess formation (HP:0002722)4.12512841
4Myositis (HP:0100614)3.82584362
5Focal motor seizures (HP:0011153)3.80026915
6Orchitis (HP:0100796)3.76801927
7Recurrent gram-negative bacterial infections (HP:0005420)3.53156390
8Myokymia (HP:0002411)3.51530323
9Optic neuritis (HP:0100653)3.46882269
10Retrobulbar optic neuritis (HP:0100654)3.46882269
11Gastrointestinal infarctions (HP:0005244)3.46372796
12Focal seizures (HP:0007359)3.44407035
13Peritonitis (HP:0002586)3.35603175
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.24512438
15Abnormality of macrophages (HP:0004311)3.15457431
16Spontaneous hematomas (HP:0007420)3.07961431
17Supranuclear gaze palsy (HP:0000605)3.02016142
18Gingivitis (HP:0000230)2.99585457
19Insidious onset (HP:0003587)2.98858845
20Termporal pattern (HP:0011008)2.98858845
21Visual hallucinations (HP:0002367)2.95734970
22Action tremor (HP:0002345)2.90994847
23Buphthalmos (HP:0000557)2.88064353
24Macroorchidism (HP:0000053)2.83781330
25Metaphyseal cupping (HP:0003021)2.80560905
26Neurofibrillary tangles (HP:0002185)2.76124478
27Cerebral inclusion bodies (HP:0100314)2.74022321
28Keratoconjunctivitis sicca (HP:0001097)2.68198499
29Recurrent fungal infections (HP:0002841)2.64858745
30Ankle clonus (HP:0011448)2.61163356
31Recurrent skin infections (HP:0001581)2.59115460
32Obstructive lung disease (HP:0006536)2.52915280
33Chronic obstructive pulmonary disease (HP:0006510)2.52915280
34Hypochromic microcytic anemia (HP:0004840)2.51896993
35Cellulitis (HP:0100658)2.51779106
36Atonic seizures (HP:0010819)2.51739750
37Meningitis (HP:0001287)2.50550914
38Absent/shortened dynein arms (HP:0200106)2.48696844
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.48696844
40Abnormality of the corticospinal tract (HP:0002492)2.47441199
41Genetic anticipation (HP:0003743)2.45328225
42Papilledema (HP:0001085)2.45311515
43Abnormality of the peritoneum (HP:0002585)2.44840942
44Megalencephaly (HP:0001355)2.44226425
45Increased IgE level (HP:0003212)2.43832498
46Urinary bladder sphincter dysfunction (HP:0002839)2.43262036
47Insomnia (HP:0100785)2.42067786
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.39651138
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39651138
50Abnormality of the fingertips (HP:0001211)2.38823836
51Dysmetria (HP:0001310)2.37677718
52Mediastinal lymphadenopathy (HP:0100721)2.37125259
53Progressive cerebellar ataxia (HP:0002073)2.37045902
54Hypochromic anemia (HP:0001931)2.36584092
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.34718346
56Subacute progressive viral hepatitis (HP:0006572)2.34300070
57Keratoconjunctivitis (HP:0001096)2.33941305
58Broad-based gait (HP:0002136)2.33674633
59Hyperacusis (HP:0010780)2.33053087
60Depression (HP:0000716)2.29466834
61Epileptic encephalopathy (HP:0200134)2.28234682
62Spastic gait (HP:0002064)2.25740174
63Recurrent cutaneous fungal infections (HP:0011370)2.24729578
64Chronic mucocutaneous candidiasis (HP:0002728)2.24729578
65Intention tremor (HP:0002080)2.22924942
66Midline defect of the nose (HP:0004122)2.20859973
67Absence seizures (HP:0002121)2.20734655
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20709619
69Short 4th metacarpal (HP:0010044)2.20709619
70Encephalitis (HP:0002383)2.18054812
71Impaired vibration sensation in the lower limbs (HP:0002166)2.15712164
72Chest pain (HP:0100749)2.13426889
73Stomatitis (HP:0010280)2.13199223
74Elevated erythrocyte sedimentation rate (HP:0003565)2.10049892
75Neoplasm of the heart (HP:0100544)2.09429586
76Dysdiadochokinesis (HP:0002075)2.09160678
77Urinary urgency (HP:0000012)2.08181180
78Prolonged bleeding time (HP:0003010)2.08003257
79Overriding aorta (HP:0002623)2.07822579
80Slow saccadic eye movements (HP:0000514)2.06088856
81Drooling (HP:0002307)2.05466517
82Excessive salivation (HP:0003781)2.05466517
83Dysmetric saccades (HP:0000641)2.05190476
84Dialeptic seizures (HP:0011146)2.04045748
85Vertebral arch anomaly (HP:0008438)2.03405764
86Vasculitis (HP:0002633)1.99787781
87Truncal ataxia (HP:0002078)1.99771134
88Obsessive-compulsive behavior (HP:0000722)1.99438510
89Widely spaced teeth (HP:0000687)1.98729349
90Retinal dysplasia (HP:0007973)1.98625075
91Vascular tortuosity (HP:0004948)1.98228952
92Gingival bleeding (HP:0000225)1.98198099
93Amyloidosis (HP:0011034)1.97655794
94Stereotypic behavior (HP:0000733)1.96527846
95Agitation (HP:0000713)1.94803910
96Episodic fever (HP:0001954)1.93675831
97Hemoptysis (HP:0002105)1.93540795
98Pointed chin (HP:0000307)1.93324865
99Amblyopia (HP:0000646)1.93297170
100Postural instability (HP:0002172)1.92303460
101Abnormal vertebral ossification (HP:0100569)1.92207821
102Segmental peripheral demyelination/remyelination (HP:0003481)1.91458348
103Urticaria (HP:0001025)1.91051248
104Pulmonary embolism (HP:0002204)1.90561016
105Generalized tonic-clonic seizures (HP:0002069)1.89760113
106Arterial thrombosis (HP:0004420)1.87153450
107Narrow palate (HP:0000189)1.86930878
108Aqueductal stenosis (HP:0002410)1.86348411
109Gaze-evoked nystagmus (HP:0000640)1.86214402
110Intellectual disability, moderate (HP:0002342)1.84396810
111Hemiparesis (HP:0001269)1.83720148
112Abnormality of the 4th metacarpal (HP:0010012)1.83687310
113Scanning speech (HP:0002168)1.82806658
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.82724604
115Rapidly progressive (HP:0003678)1.81247248
116Elfin facies (HP:0004428)1.80969431
117Shallow orbits (HP:0000586)1.80919545
118Renal duplication (HP:0000075)1.80853811
119Arnold-Chiari malformation (HP:0002308)1.80605382
120Abnormality of the endocardium (HP:0004306)1.79682261
121Dilatation of the ascending aorta (HP:0005111)1.79498356
122Viral hepatitis (HP:0006562)1.79227632
123Sacral dimple (HP:0000960)1.79104771
124Absent speech (HP:0001344)1.79000947
125Anteriorly placed anus (HP:0001545)1.78447469
126Cerebral aneurysm (HP:0004944)1.78408206
127Broad palm (HP:0001169)1.78177714
128Annular pancreas (HP:0001734)1.77307010
129Congenital glaucoma (HP:0001087)1.77074027
130Ankyloglossia (HP:0010296)1.76913746
131Dislocated radial head (HP:0003083)1.76397204
132T lymphocytopenia (HP:0005403)1.75745406
133Hyporeflexia of lower limbs (HP:0002600)1.74857305
134Neuronal loss in central nervous system (HP:0002529)1.74651860
135Syringomyelia (HP:0003396)1.74548830
136Spinal cord lesions (HP:0100561)1.74548830
137Heterotopia (HP:0002282)1.73014289
138Volvulus (HP:0002580)1.72754315
139Renovascular hypertension (HP:0100817)1.72596943
140Open mouth (HP:0000194)1.72373631
141Anxiety (HP:0000739)1.71468893
142Lower limb muscle weakness (HP:0007340)1.70588350
143Neonatal hypoglycemia (HP:0001998)1.70288371
144Mitral valve prolapse (HP:0001634)1.69746531
145Neoplasm of the tracheobronchial system (HP:0100552)1.69594029
146Bowel incontinence (HP:0002607)1.67743918
147Hypoventilation (HP:0002791)1.67159631
148Arterial tortuosity (HP:0005116)1.65867007
149Germ cell neoplasia (HP:0100728)1.65773251
150Mutism (HP:0002300)1.65330379
151Exotropia (HP:0000577)1.65151267
152Asymmetry of the thorax (HP:0001555)1.64439334
153Muscle hypertrophy of the lower extremities (HP:0008968)1.64420186
154Abnormality of the radial head (HP:0003995)1.64315282
155Type II lissencephaly (HP:0007260)1.63967630
156Obstructive sleep apnea (HP:0002870)1.63698874
157Truncal obesity (HP:0001956)1.63679224
158Difficulty running (HP:0009046)1.63443350
159Deep palmar crease (HP:0006191)1.63139195
160Thickened calvaria (HP:0002684)1.63092885
161Amyotrophic lateral sclerosis (HP:0007354)1.62988098
162Broad metatarsal (HP:0001783)1.62875424
163Abnormality of incisor morphology (HP:0011063)1.62752133
164Osteomyelitis (HP:0002754)1.62701831
165Aplasia involving bones of the upper limbs (HP:0009823)1.62293819
166Aplasia of the phalanges of the hand (HP:0009802)1.62293819
167Aplasia involving bones of the extremities (HP:0009825)1.62293819
168Postural tremor (HP:0002174)1.61612069
169Sensory axonal neuropathy (HP:0003390)1.61597550
170Onion bulb formation (HP:0003383)1.61550502
171Hyperthyroidism (HP:0000836)1.61526372
172Flat acetabular roof (HP:0003180)1.61289291
173Flat cornea (HP:0007720)1.61080296
174Febrile seizures (HP:0002373)1.60902162
175Gastrointestinal inflammation (HP:0004386)1.60854431
176Sepsis (HP:0100806)1.59422398
177Deep philtrum (HP:0002002)1.58693545
178Broad face (HP:0000283)1.57671795
179Leukocytosis (HP:0001974)1.55068305
180Overgrowth (HP:0001548)1.54293910
181Supernumerary ribs (HP:0005815)1.53616997
182Abnormality of T cell number (HP:0011839)1.53612085
183Inflammation of the large intestine (HP:0002037)1.52781852
184Epistaxis (HP:0000421)1.52109207
185Pulmonary infiltrates (HP:0002113)1.51794759
186Transitional cell carcinoma of the bladder (HP:0006740)1.50341650
187Alveolar cell carcinoma (HP:0006519)1.48263362
188Abnormality of the pleura (HP:0002103)1.48205813
189Microcytic anemia (HP:0001935)1.47916715
190Papillary thyroid carcinoma (HP:0002895)1.47809126
191Lower limb asymmetry (HP:0100559)1.47623499
192Mitral regurgitation (HP:0001653)1.46574055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.45321026
2EPHA42.63360360
3PRKD32.63037667
4MARK12.58846929
5PRPF4B2.53285714
6PNCK2.52604226
7CAMK1G2.49612999
8NTRK32.49372911
9MAP3K92.42236548
10MAP2K32.28235456
11BLK2.11265010
12IRAK42.10629582
13ICK2.07168445
14YES12.03970505
15ERN11.90838771
16CSK1.90038444
17SIK21.89232053
18TYRO31.88354248
19TYK21.79831580
20PAK61.78315319
21KSR21.72206808
22STK391.69564945
23EPHB11.67723197
24MAP3K41.67504594
25MAP4K11.64947088
26TNIK1.62559367
27WNK11.61869007
28UHMK11.59296859
29NTRK21.58743178
30MINK11.58336665
31FGFR21.57725239
32FES1.56648981
33FGFR41.54744575
34DMPK1.48706295
35ZAP701.44910849
36FGFR31.40194960
37TRIB31.35973246
38MARK21.34334965
39KSR11.31453895
40MAP3K21.25844955
41CDK51.23917724
42GRK61.21820320
43DAPK21.21242406
44RET1.20355723
45WNK41.19650015
46CAMKK11.18883326
47STK111.18866096
48NTRK11.18070273
49MAP3K61.16952429
50IRAK21.15223488
51JAK21.14813173
52ALK1.13636980
53RIPK11.13546396
54MATK1.12399636
55HCK1.11945957
56CSNK1G21.10559511
57PTK2B1.09944866
58STK381.08621587
59PRKCH1.07727517
60MAPK131.06195264
61SIK11.06054839
62BRD41.05013928
63RIPK41.04031552
64MAP3K101.02893621
65CAMK1D1.02707089
66BTK1.01855927
67SGK21.01681828
68MAP3K140.99886491
69PHKG10.99036394
70PHKG20.99036394
71MAP3K70.98901886
72JAK30.97299805
73CSNK1A1L0.96986696
74PKN20.95491140
75FGR0.93020105
76IRAK10.92507904
77MAP2K40.90893478
78CSF1R0.90380967
79PAK30.89614812
80JAK10.89396019
81SMG10.89005230
82TAOK10.87365615
83MAP3K30.84280929
84MAP3K130.84129587
85EPHB20.82173353
86PDGFRB0.81187199
87CAMK10.81028312
88LRRK20.80577089
89OXSR10.79380272
90CSNK1G30.78631689
91PDGFRA0.78096116
92PDK10.78033244
93SYK0.73059042
94PDPK10.72456860
95DYRK1B0.72277240
96FYN0.71447127
97CDK190.70183511
98NLK0.69712455
99PTK60.69614800
100CSNK1G10.69298811
101SGK30.69184145
102MARK30.68955684
103LYN0.67066723
104SIK30.65941648
105SGK2230.65586135
106SGK4940.65586135
107HIPK20.64636256
108IKBKE0.63703780
109ROCK20.62838047
110PKN10.62184975
111CAMK2A0.62036948
112SGK10.60742825
113PRKD10.59661131
114CDK140.59626909
115ERBB20.59258764
116EEF2K0.56589717
117MAPK120.56398528
118CDK150.56199058
119CDK60.55948500
120LATS10.55933355
121LCK0.55724791
122RAF10.54628615
123RPS6KC10.54188853
124RPS6KL10.54188853
125STK240.53794893
126MAPK70.53487580
127BMX0.53369716
128CDC42BPA0.52243758
129PRKCG0.51681714
130CDK180.51641631
131ITK0.51453626
132DDR20.50872591
133CAMK40.50784575
134TNK20.50109161
135MAP2K70.49884904
136PLK20.49593063
137GRK50.48163465
138PRKD20.47912369
139MAP3K10.47846866
140CDK11A0.47280794
141MAPKAPK50.47148082
142FGFR10.46963389
143MAPK100.45747831
144LATS20.45396564
145RPS6KA30.45154241
146CSNK1D0.43074563
147FER0.42539204
148PRKCZ0.42500731
149DYRK1A0.42444714

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.11910494
2Osteoclast differentiation_Homo sapiens_hsa043802.09532320
3Olfactory transduction_Homo sapiens_hsa047402.06139918
4Glutamatergic synapse_Homo sapiens_hsa047242.03631813
5Nicotine addiction_Homo sapiens_hsa050332.02090862
6Circadian entrainment_Homo sapiens_hsa047132.00197654
7Leishmaniasis_Homo sapiens_hsa051401.85372916
8Acute myeloid leukemia_Homo sapiens_hsa052211.83842885
9Amphetamine addiction_Homo sapiens_hsa050311.83720467
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80451488
11Morphine addiction_Homo sapiens_hsa050321.79217468
12Dopaminergic synapse_Homo sapiens_hsa047281.77627412
13GABAergic synapse_Homo sapiens_hsa047271.74532662
14Renin secretion_Homo sapiens_hsa049241.74348842
15Dorso-ventral axis formation_Homo sapiens_hsa043201.70649233
16Salivary secretion_Homo sapiens_hsa049701.68696814
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67643393
18Cholinergic synapse_Homo sapiens_hsa047251.65140505
19Axon guidance_Homo sapiens_hsa043601.64336120
20Gastric acid secretion_Homo sapiens_hsa049711.64254563
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62715822
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59489763
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57972218
24Long-term depression_Homo sapiens_hsa047301.55860342
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49983135
26Cocaine addiction_Homo sapiens_hsa050301.49939790
27Insulin secretion_Homo sapiens_hsa049111.48811616
28Oxytocin signaling pathway_Homo sapiens_hsa049211.47657592
29Notch signaling pathway_Homo sapiens_hsa043301.47520569
30Synaptic vesicle cycle_Homo sapiens_hsa047211.46084345
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41556487
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38803554
33Estrogen signaling pathway_Homo sapiens_hsa049151.36994943
34Staphylococcus aureus infection_Homo sapiens_hsa051501.36911866
35Glioma_Homo sapiens_hsa052141.36003271
36Tuberculosis_Homo sapiens_hsa051521.35299252
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30474716
38Gap junction_Homo sapiens_hsa045401.28449623
39GnRH signaling pathway_Homo sapiens_hsa049121.28342271
40Measles_Homo sapiens_hsa051621.26566029
41Type II diabetes mellitus_Homo sapiens_hsa049301.24581266
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23658326
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22497614
44Serotonergic synapse_Homo sapiens_hsa047261.21363228
45cAMP signaling pathway_Homo sapiens_hsa040241.20707376
46FoxO signaling pathway_Homo sapiens_hsa040681.19700446
47Renal cell carcinoma_Homo sapiens_hsa052111.19142920
48Melanogenesis_Homo sapiens_hsa049161.18471316
49ErbB signaling pathway_Homo sapiens_hsa040121.18389759
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17052007
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15926375
52Calcium signaling pathway_Homo sapiens_hsa040201.15292597
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.15186180
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12773478
55Hepatitis B_Homo sapiens_hsa051611.11450402
56Taste transduction_Homo sapiens_hsa047421.09352814
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.08519948
58VEGF signaling pathway_Homo sapiens_hsa043701.07853135
59Inositol phosphate metabolism_Homo sapiens_hsa005621.05526886
60Toxoplasmosis_Homo sapiens_hsa051451.04418144
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03512075
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.03407570
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00865986
64Malaria_Homo sapiens_hsa051441.00422486
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.99837644
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99729468
67Dilated cardiomyopathy_Homo sapiens_hsa054140.98858992
68Hepatitis C_Homo sapiens_hsa051600.98617591
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98393471
70Influenza A_Homo sapiens_hsa051640.98066685
71Endometrial cancer_Homo sapiens_hsa052130.97787951
72TNF signaling pathway_Homo sapiens_hsa046680.92800463
73Non-small cell lung cancer_Homo sapiens_hsa052230.91771531
74Choline metabolism in cancer_Homo sapiens_hsa052310.91501283
75Wnt signaling pathway_Homo sapiens_hsa043100.91038867
76mTOR signaling pathway_Homo sapiens_hsa041500.89956747
77MAPK signaling pathway_Homo sapiens_hsa040100.89784068
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.89708131
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88135584
80Thyroid cancer_Homo sapiens_hsa052160.86627959
81Amoebiasis_Homo sapiens_hsa051460.86565848
82Rap1 signaling pathway_Homo sapiens_hsa040150.86440434
83Pancreatic secretion_Homo sapiens_hsa049720.85530367
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84243136
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83772557
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82776942
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82368915
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81410072
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81228664
90Ras signaling pathway_Homo sapiens_hsa040140.80601263
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.80281633
92Endocytosis_Homo sapiens_hsa041440.78356947
93Hedgehog signaling pathway_Homo sapiens_hsa043400.78183008
94Glucagon signaling pathway_Homo sapiens_hsa049220.77910878
95HIF-1 signaling pathway_Homo sapiens_hsa040660.77699722
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.77407526
97Colorectal cancer_Homo sapiens_hsa052100.75609298
98Oocyte meiosis_Homo sapiens_hsa041140.73249512
99Herpes simplex infection_Homo sapiens_hsa051680.73197838
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72639882
101Nitrogen metabolism_Homo sapiens_hsa009100.72456975
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72401977
103Thyroid hormone synthesis_Homo sapiens_hsa049180.72165642
104Platelet activation_Homo sapiens_hsa046110.72150806
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.71990287
106Chronic myeloid leukemia_Homo sapiens_hsa052200.70900698
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.70813098
108Basal cell carcinoma_Homo sapiens_hsa052170.70446872
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70184591
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70124543
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68881414
112MicroRNAs in cancer_Homo sapiens_hsa052060.68250332
113B cell receptor signaling pathway_Homo sapiens_hsa046620.68041112
114African trypanosomiasis_Homo sapiens_hsa051430.66956591
115Cardiac muscle contraction_Homo sapiens_hsa042600.66495152
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66057673
117Proteoglycans in cancer_Homo sapiens_hsa052050.65546402
118Apoptosis_Homo sapiens_hsa042100.64104601
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63604436
120Bladder cancer_Homo sapiens_hsa052190.63283009
121Legionellosis_Homo sapiens_hsa051340.62947413
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62916569
123Phagosome_Homo sapiens_hsa041450.62811534
124Focal adhesion_Homo sapiens_hsa045100.62562623
125T cell receptor signaling pathway_Homo sapiens_hsa046600.61366743
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61234886
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61170760
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60614035
129Insulin signaling pathway_Homo sapiens_hsa049100.60404286
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59546048
131Small cell lung cancer_Homo sapiens_hsa052220.59343502
132Fatty acid biosynthesis_Homo sapiens_hsa000610.58728414
133Tight junction_Homo sapiens_hsa045300.57656524
134Salmonella infection_Homo sapiens_hsa051320.55987898
135Pathways in cancer_Homo sapiens_hsa052000.55848903
136Ovarian steroidogenesis_Homo sapiens_hsa049130.55511823
137Chemokine signaling pathway_Homo sapiens_hsa040620.55346191
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54058273
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54009787
140Viral myocarditis_Homo sapiens_hsa054160.53762568
141Pancreatic cancer_Homo sapiens_hsa052120.52908033
142Prolactin signaling pathway_Homo sapiens_hsa049170.50199088
143Prostate cancer_Homo sapiens_hsa052150.50010089
144Hippo signaling pathway_Homo sapiens_hsa043900.49469320
145Insulin resistance_Homo sapiens_hsa049310.48342421
146Adherens junction_Homo sapiens_hsa045200.48246060

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