MSI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66315506
2cilium or flagellum-dependent cell motility (GO:0001539)3.49792501
3cilium movement (GO:0003341)3.36484247
4postsynaptic membrane organization (GO:0001941)3.34691422
5embryonic retina morphogenesis in camera-type eye (GO:0060059)3.31984817
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.30908034
7behavioral response to nicotine (GO:0035095)3.28555656
8axonemal dynein complex assembly (GO:0070286)3.26793989
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25434661
10axon ensheathment in central nervous system (GO:0032291)3.20253894
11central nervous system myelination (GO:0022010)3.20253894
12cell communication by electrical coupling (GO:0010644)3.19275769
13negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16432953
14presynaptic membrane assembly (GO:0097105)3.12654195
15eye photoreceptor cell differentiation (GO:0001754)3.12128387
16photoreceptor cell differentiation (GO:0046530)3.12128387
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11100805
18epithelial cilium movement (GO:0003351)3.10441615
19negative regulation of potassium ion transmembrane transport (GO:1901380)3.05261024
20regulation of membrane repolarization (GO:0060306)2.96276590
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.94843752
22camera-type eye morphogenesis (GO:0048593)2.91551083
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.90882591
24photoreceptor cell development (GO:0042461)2.88024316
25retinal rod cell development (GO:0046548)2.87953952
26neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.86128194
27cardiac myofibril assembly (GO:0055003)2.85169139
28presynaptic membrane organization (GO:0097090)2.84709481
29otic vesicle formation (GO:0030916)2.84535711
30ventricular system development (GO:0021591)2.83397344
31tongue development (GO:0043586)2.80873716
32eye photoreceptor cell development (GO:0042462)2.79733883
33histone H3-K9 methylation (GO:0051567)2.79610793
34mechanosensory behavior (GO:0007638)2.78969211
35insulin-like growth factor receptor signaling pathway (GO:0048009)2.78913593
36lateral sprouting from an epithelium (GO:0060601)2.77794546
37retinal cone cell development (GO:0046549)2.74810754
38cytoplasmic mRNA processing body assembly (GO:0033962)2.74113490
39nucleus localization (GO:0051647)2.72790973
40layer formation in cerebral cortex (GO:0021819)2.71779251
41organ growth (GO:0035265)2.70676322
42histone H3-K4 trimethylation (GO:0080182)2.70416648
43regulation of secondary heart field cardioblast proliferation (GO:0003266)2.68838742
44regulation of cardioblast proliferation (GO:0003264)2.68838742
45motile cilium assembly (GO:0044458)2.68643734
46cardiac muscle contraction (GO:0060048)2.68521606
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.68462445
48mitotic sister chromatid cohesion (GO:0007064)2.67628317
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67217908
50negative regulation of oligodendrocyte differentiation (GO:0048715)2.67091354
51negative regulation of astrocyte differentiation (GO:0048712)2.64303875
52positive regulation by host of viral transcription (GO:0043923)2.63609463
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63347156
54lung epithelium development (GO:0060428)2.62205936
55potassium ion import (GO:0010107)2.59185117
56positive regulation of developmental pigmentation (GO:0048087)2.58363008
57appendage development (GO:0048736)2.58000901
58limb development (GO:0060173)2.58000901
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56640276
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.54868816
61membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54685278
62relaxation of cardiac muscle (GO:0055119)2.53869662
63establishment of nucleus localization (GO:0040023)2.53837042
64forebrain neuron differentiation (GO:0021879)2.52976711
65astrocyte development (GO:0014002)2.50157690
66potassium ion homeostasis (GO:0055075)2.50065211
67histone H3-K9 modification (GO:0061647)2.49993380
68neuronal stem cell maintenance (GO:0097150)2.49081546
69dorsal/ventral axis specification (GO:0009950)2.47143632
70interkinetic nuclear migration (GO:0022027)2.47127656
71protein-DNA complex disassembly (GO:0032986)2.46719332
72nucleosome disassembly (GO:0006337)2.46719332
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45877862
74regulation of pigment cell differentiation (GO:0050932)2.45801732
75adult heart development (GO:0007512)2.44912830
76regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44773275
77membrane repolarization (GO:0086009)2.44713305
78rhodopsin mediated signaling pathway (GO:0016056)2.43777129
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43510085
80positive regulation of potassium ion transmembrane transport (GO:1901381)2.43256689
81negative regulation of histone methylation (GO:0031061)2.43047271
82cerebellar Purkinje cell differentiation (GO:0021702)2.42922811
83sodium ion export (GO:0071436)2.42884389
84membrane repolarization during action potential (GO:0086011)2.41342057
85cellular potassium ion homeostasis (GO:0030007)2.41045022
86cell communication involved in cardiac conduction (GO:0086065)2.40538520
87ear development (GO:0043583)2.40414562
88neuron cell-cell adhesion (GO:0007158)2.40022589
89protein targeting to Golgi (GO:0000042)2.39877816
90embryonic camera-type eye morphogenesis (GO:0048596)2.39506534
91regulation of growth hormone secretion (GO:0060123)2.39279540
92spinal cord development (GO:0021510)2.39200032
93stress granule assembly (GO:0034063)2.38092935
94cellular response to cholesterol (GO:0071397)2.37488750
95atrial cardiac muscle cell action potential (GO:0086014)2.35253592
96photoreceptor cell maintenance (GO:0045494)2.34273756
97regulation of potassium ion transmembrane transporter activity (GO:1901016)2.34117020
98neurotransmitter catabolic process (GO:0042135)2.34042942
99nonmotile primary cilium assembly (GO:0035058)2.33356071
100regulation of somitogenesis (GO:0014807)2.33238920
101lateral ventricle development (GO:0021670)2.32872228
102locomotory exploration behavior (GO:0035641)2.32616013
103cell-cell signaling involved in cell fate commitment (GO:0045168)2.32366620
104ectodermal placode formation (GO:0060788)2.32107960
105myofibril assembly (GO:0030239)2.32057863
106positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.31884177
107regulation of skeletal muscle cell differentiation (GO:2001014)2.31747140
108positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.31421619
109heart valve formation (GO:0003188)2.30754769
110mesenchyme morphogenesis (GO:0072132)2.30708923
111regulation of potassium ion transmembrane transport (GO:1901379)2.29442572
112histone lysine methylation (GO:0034968)2.28809801
113sarcomere organization (GO:0045214)2.28357213
114heart morphogenesis (GO:0003007)2.28238693
115detection of calcium ion (GO:0005513)2.27977775
116endocardial cushion morphogenesis (GO:0003203)2.27898831
117positive regulation of hormone biosynthetic process (GO:0046886)2.27857601
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.27313857
119intraciliary transport (GO:0042073)2.26908377
120developmental induction (GO:0031128)2.26527651
121innervation (GO:0060384)2.25705212
122V(D)J recombination (GO:0033151)2.25704934
123pre-miRNA processing (GO:0031054)2.25334233
124positive regulation of histone deacetylation (GO:0031065)2.25223064
125regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.25192763
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.23591355
127regulation of respiratory system process (GO:0044065)2.22304075
128ionotropic glutamate receptor signaling pathway (GO:0035235)2.22225196
129peptidyl-lysine methylation (GO:0018022)2.22148569
130regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.21888440
131cerebellar granule cell differentiation (GO:0021707)2.21751318
132retina layer formation (GO:0010842)2.21560905
133histone H3-K9 demethylation (GO:0033169)2.20948182
134generation of neurons (GO:0048699)2.20826755
135regulation of actin filament-based movement (GO:1903115)2.20533549
136synaptic vesicle maturation (GO:0016188)2.20062078
137peptidyl-lysine dimethylation (GO:0018027)2.19844921
138establishment of protein localization to Golgi (GO:0072600)2.19773165
139positive regulation of dendrite morphogenesis (GO:0050775)2.19316949
140pyrimidine nucleobase catabolic process (GO:0006208)2.19316479
141axoneme assembly (GO:0035082)2.19038199
142regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.18490594
143positive regulation of potassium ion transport (GO:0043268)2.18385239
144cell migration in hindbrain (GO:0021535)2.18359147
145positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.17754868
146left/right pattern formation (GO:0060972)2.17385140
147cranial nerve development (GO:0021545)2.16196968
148cilium assembly (GO:0042384)2.15517664
149cilium organization (GO:0044782)2.14143223
150positive regulation of CREB transcription factor activity (GO:0032793)2.14087354
151inositol metabolic process (GO:0006020)2.13921199
152striated muscle contraction (GO:0006941)2.13808604
153definitive hemopoiesis (GO:0060216)2.13544536
154cranial nerve morphogenesis (GO:0021602)2.12218008
155somite development (GO:0061053)2.11734499
156regulation of respiratory gaseous exchange (GO:0043576)2.11544722
157regulation of skeletal muscle contraction (GO:0014819)2.11190205
158axonal fasciculation (GO:0007413)2.11121516
159glial cell proliferation (GO:0014009)2.11032860
160peptidyl-lysine trimethylation (GO:0018023)2.10263809
161monoubiquitinated protein deubiquitination (GO:0035520)2.09767128
162central nervous system projection neuron axonogenesis (GO:0021952)2.09278346
163neuron recognition (GO:0008038)2.09194243
164cellular response to sterol (GO:0036315)2.08977908
165regulation of heart morphogenesis (GO:2000826)2.08669992
166plasma membrane repair (GO:0001778)2.08292419
167auditory behavior (GO:0031223)2.08281028
168muscle filament sliding (GO:0030049)2.08260030
169actin-myosin filament sliding (GO:0033275)2.08260030
170mRNA splice site selection (GO:0006376)2.07858606
171negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.07544100
172negative regulation of translation, ncRNA-mediated (GO:0040033)2.07544100
173regulation of translation, ncRNA-mediated (GO:0045974)2.07544100
174positive regulation of neuroblast proliferation (GO:0002052)2.07293655
175neuromuscular synaptic transmission (GO:0007274)2.07065705
176negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.07036991
177neural tube formation (GO:0001841)2.06391298
178asymmetric protein localization (GO:0008105)2.06336006
179positive regulation of cation channel activity (GO:2001259)2.05905802
180neuromuscular junction development (GO:0007528)2.05665835
181negative regulation of glial cell differentiation (GO:0045686)2.04907541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.44512837
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78347675
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20783197
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13753704
5GBX2_23144817_ChIP-Seq_PC3_Human2.05810075
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02774417
7SALL1_21062744_ChIP-ChIP_HESCs_Human1.98300840
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97000233
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92877022
10DROSHA_22980978_ChIP-Seq_HELA_Human1.88045081
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87419296
12AR_21572438_ChIP-Seq_LNCaP_Human1.86430112
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84550678
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83812714
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.81635911
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81104539
17RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.76081152
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75986465
19* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75648552
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75396148
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74350207
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.74318205
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71802727
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71802727
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68526696
26* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68302310
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.66558482
28RNF2_27304074_Chip-Seq_NSC_Mouse1.65615003
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65278842
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.63346358
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60326485
32* ISL1_27105846_Chip-Seq_CPCs_Mouse1.59741517
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.57181381
34* REST_21632747_ChIP-Seq_MESCs_Mouse1.57072351
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.56580911
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55424813
37TAF15_26573619_Chip-Seq_HEK293_Human1.51778135
38ZNF274_21170338_ChIP-Seq_K562_Hela1.51569382
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51432874
40* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51265675
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50080846
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49401426
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47646063
44* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.46956930
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.46722946
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46546817
47* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44107471
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.43612158
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43132025
50EWS_26573619_Chip-Seq_HEK293_Human1.41747342
51FUS_26573619_Chip-Seq_HEK293_Human1.40076169
52* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.39967046
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37828507
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37777283
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37222895
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36915344
57* AR_19668381_ChIP-Seq_PC3_Human1.35118560
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35003445
59* ARNT_22903824_ChIP-Seq_MCF-7_Human1.34877105
60* ER_23166858_ChIP-Seq_MCF-7_Human1.33810285
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33209352
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33168508
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.32716696
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32580556
65* AHR_22903824_ChIP-Seq_MCF-7_Human1.31486747
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31441205
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31055140
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.30877987
69* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30111209
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28968386
71* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28768052
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27838902
73* STAT3_23295773_ChIP-Seq_U87_Human1.27635831
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27101347
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.26601326
76* RARB_27405468_Chip-Seq_BRAIN_Mouse1.26211158
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.25046113
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24818056
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24764560
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24241872
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23316816
82BCAT_22108803_ChIP-Seq_LS180_Human1.23006317
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.22942874
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.22841432
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22535696
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22246445
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21942835
88* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20988898
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20341125
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19674280
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18004765
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17899093
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17491338
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16838766
95* TP53_16413492_ChIP-PET_HCT116_Human1.14953481
96* TCF4_23295773_ChIP-Seq_U87_Human1.14907375
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14675817
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14479516
99* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13841420
100* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13841420
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13624913
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13380096
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13266644
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.12476821
105* SOX9_26525672_Chip-Seq_HEART_Mouse1.11753971
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11751848
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11007940
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10531552
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09741625
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08888006
111IGF1R_20145208_ChIP-Seq_DFB_Human1.08583949
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07290567
113* P300_19829295_ChIP-Seq_ESCs_Human1.06980939
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06781061
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06554652
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06500145
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06109476
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05673045
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04416175
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.02707207
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00241776
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99976550
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99890824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.43181024
2MP0006072_abnormal_retinal_apoptosis3.03349736
3MP0003122_maternal_imprinting2.41005057
4MP0005551_abnormal_eye_electrophysiolog2.37857175
5MP0002822_catalepsy2.28293433
6MP0009780_abnormal_chondrocyte_physiolo2.25441666
7MP0008057_abnormal_DNA_replication2.22276152
8MP0005253_abnormal_eye_physiology2.20634366
9MP0004084_abnormal_cardiac_muscle2.08200085
10MP0004215_abnormal_myocardial_fiber2.03823437
11MP0000751_myopathy1.90707454
12MP0003121_genomic_imprinting1.89144796
13MP0002909_abnormal_adrenal_gland1.84461204
14MP0004145_abnormal_muscle_electrophysio1.76897403
15MP0002837_dystrophic_cardiac_calcinosis1.70872207
16MP0005646_abnormal_pituitary_gland1.69034728
17MP0004233_abnormal_muscle_weight1.67176901
18MP0000383_abnormal_hair_follicle1.61445102
19MP0000537_abnormal_urethra_morphology1.60805597
20MP0002877_abnormal_melanocyte_morpholog1.59836273
21MP0001984_abnormal_olfaction1.58975911
22MP0000631_abnormal_neuroendocrine_gland1.56539839
23MP0002234_abnormal_pharynx_morphology1.55890140
24MP0003787_abnormal_imprinting1.55274201
25MP0004036_abnormal_muscle_relaxation1.55180905
26MP0002009_preneoplasia1.47358100
27MP0000955_abnormal_spinal_cord1.43566009
28MP0004885_abnormal_endolymph1.41565062
29MP0003137_abnormal_impulse_conducting1.41035446
30MP0004133_heterotaxia1.40299711
31MP0001299_abnormal_eye_distance/1.37620310
32MP0003123_paternal_imprinting1.37062068
33MP0005187_abnormal_penis_morphology1.35080807
34MP0005423_abnormal_somatic_nervous1.34534260
35MP0004085_abnormal_heartbeat1.34416508
36MP0002184_abnormal_innervation1.33186599
37MP0005623_abnormal_meninges_morphology1.31895689
38MP0005171_absent_coat_pigmentation1.30637584
39MP0000049_abnormal_middle_ear1.28600658
40MP0009379_abnormal_foot_pigmentation1.27881045
41MP0005391_vision/eye_phenotype1.27163445
42MP0000749_muscle_degeneration1.25938774
43MP0000428_abnormal_craniofacial_morphol1.24089353
44MP0003935_abnormal_craniofacial_develop1.23187745
45MP0005394_taste/olfaction_phenotype1.23026792
46MP0005499_abnormal_olfactory_system1.23026792
47MP0010030_abnormal_orbit_morphology1.22917539
48MP0008789_abnormal_olfactory_epithelium1.21787787
49MP0003283_abnormal_digestive_organ1.21028829
50MP0004087_abnormal_muscle_fiber1.19534605
51MP0002638_abnormal_pupillary_reflex1.19451325
52MP0002063_abnormal_learning/memory/cond1.19006305
53MP0004270_analgesia1.18575826
54MP0002697_abnormal_eye_size1.18411003
55MP0002396_abnormal_hematopoietic_system1.18230508
56MP0003937_abnormal_limbs/digits/tail_de1.18024483
57MP0003880_abnormal_central_pattern1.17405407
58MP0001486_abnormal_startle_reflex1.17344791
59MP0010630_abnormal_cardiac_muscle1.16278281
60MP0005248_abnormal_Harderian_gland1.15976385
61MP0004043_abnormal_pH_regulation1.15257116
62MP0005620_abnormal_muscle_contractility1.13958445
63MP0005195_abnormal_posterior_eye1.13939751
64MP0003938_abnormal_ear_development1.13648884
65MP0002972_abnormal_cardiac_muscle1.13383462
66MP0001270_distended_abdomen1.12041927
67MP0002064_seizures1.10098921
68MP0006292_abnormal_olfactory_placode1.09846747
69MP0000778_abnormal_nervous_system1.09694999
70MP0009250_abnormal_appendicular_skeleto1.09673521
71MP0003942_abnormal_urinary_system1.09639867
72MP0000569_abnormal_digit_pigmentation1.08931178
73MP0005330_cardiomyopathy1.08443730
74MP0002233_abnormal_nose_morphology1.08091321
75MP0002751_abnormal_autonomic_nervous1.07844558
76MP0000534_abnormal_ureter_morphology1.07756040
77MP0005076_abnormal_cell_differentiation1.05668607
78MP0002572_abnormal_emotion/affect_behav1.04543119
79MP0002106_abnormal_muscle_physiology1.03976819
80MP0003890_abnormal_embryonic-extraembry1.03923503
81MP0001346_abnormal_lacrimal_gland1.03085001
82MP0008569_lethality_at_weaning1.03037246
83MP0002653_abnormal_ependyma_morphology1.02739784
84MP0003646_muscle_fatigue1.02735002
85MP0003635_abnormal_synaptic_transmissio1.02685946
86MP0002557_abnormal_social/conspecific_i1.02017348
87MP0002127_abnormal_cardiovascular_syste1.01901832
88MP0004484_altered_response_of1.01777293
89MP0002108_abnormal_muscle_morphology1.01758694
90MP0008995_early_reproductive_senescence1.01741278
91MP0002928_abnormal_bile_duct0.98935446
92MP0001502_abnormal_circadian_rhythm0.98365284
93MP0005369_muscle_phenotype0.97908806
94MP0000026_abnormal_inner_ear0.97864902
95MP0002734_abnormal_mechanical_nocicepti0.97688923
96MP0002092_abnormal_eye_morphology0.97683463
97MP0001485_abnormal_pinna_reflex0.96898631
98MP0006276_abnormal_autonomic_nervous0.96580965
99MP0004142_abnormal_muscle_tone0.95906494
100MP0004859_abnormal_synaptic_plasticity0.95903031
101MP0003011_delayed_dark_adaptation0.95787739
102MP0008775_abnormal_heart_ventricle0.95287695
103MP0010678_abnormal_skin_adnexa0.94966646
104MP0000747_muscle_weakness0.94400817
105MP0005220_abnormal_exocrine_pancreas0.93773561
106MP0001879_abnormal_lymphatic_vessel0.93443793
107MP0000733_abnormal_muscle_development0.92931652
108MP0009384_cardiac_valve_regurgitation0.92767828
109MP0008961_abnormal_basal_metabolism0.92588232
110MP0002116_abnormal_craniofacial_bone0.92417038
111MP0003943_abnormal_hepatobiliary_system0.92070613
112MP0001286_abnormal_eye_development0.91188100
113MP0002882_abnormal_neuron_morphology0.90275206
114MP0000566_synostosis0.90154760
115MP0009046_muscle_twitch0.89866383
116MP0002735_abnormal_chemical_nociception0.89669643
117MP0005377_hearing/vestibular/ear_phenot0.89496263
118MP0003878_abnormal_ear_physiology0.89496263
119MP0002249_abnormal_larynx_morphology0.88884542
120MP0009745_abnormal_behavioral_response0.88748900
121MP0002752_abnormal_somatic_nervous0.88275607
122MP0002160_abnormal_reproductive_system0.88209217
123MP0005409_darkened_coat_color0.88161913
124MP0002067_abnormal_sensory_capabilities0.86683080
125MP0002090_abnormal_vision0.85886562
126MP0003861_abnormal_nervous_system0.84820911
127MP0003567_abnormal_fetal_cardiomyocyte0.84817647
128MP0005645_abnormal_hypothalamus_physiol0.84601966
129MP0009703_decreased_birth_body0.84580871
130MP0002084_abnormal_developmental_patter0.84512600
131MP0001293_anophthalmia0.83880821
132MP0003755_abnormal_palate_morphology0.83133859
133MP0003632_abnormal_nervous_system0.82597454
134MP0004924_abnormal_behavior0.81922544
135MP0005386_behavior/neurological_phenoty0.81922544
136MP0002938_white_spotting0.81709202
137MP0002152_abnormal_brain_morphology0.80711367
138MP0002081_perinatal_lethality0.80423562
139MP0001188_hyperpigmentation0.79631920
140MP0000759_abnormal_skeletal_muscle0.78972435
141MP0001944_abnormal_pancreas_morphology0.76991655
142* MP0010770_preweaning_lethality0.75443515

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.34196428
2Central scotoma (HP:0000603)3.24201380
3Macroorchidism (HP:0000053)3.07993384
4Bony spicule pigmentary retinopathy (HP:0007737)2.96219030
5Absent/shortened dynein arms (HP:0200106)2.85662920
6Dynein arm defect of respiratory motile cilia (HP:0012255)2.85662920
7Volvulus (HP:0002580)2.84133774
8Abnormal respiratory motile cilium morphology (HP:0005938)2.78887769
9Abnormal respiratory epithelium morphology (HP:0012253)2.78887769
10Scotoma (HP:0000575)2.69124884
11Prolonged QT interval (HP:0001657)2.68653211
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.60248416
13Abnormal respiratory motile cilium physiology (HP:0012261)2.57210308
14Acute lymphatic leukemia (HP:0006721)2.55426410
15Hypoplastic ischia (HP:0003175)2.50091523
16Calf muscle hypertrophy (HP:0008981)2.47824955
17Abnormality of the calf musculature (HP:0001430)2.46204730
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45832175
19Atrial fibrillation (HP:0005110)2.38364141
20Abnormality of the left ventricular outflow tract (HP:0011103)2.33018409
21Subaortic stenosis (HP:0001682)2.33018409
22Hyperkalemia (HP:0002153)2.31954245
23Papillary thyroid carcinoma (HP:0002895)2.30585979
24Rhinitis (HP:0012384)2.29859019
25Abnormality of macular pigmentation (HP:0008002)2.29763903
26Muscle hypertrophy of the lower extremities (HP:0008968)2.28205214
27Exercise-induced myalgia (HP:0003738)2.27905470
28Chorioretinal atrophy (HP:0000533)2.26785248
29Primary atrial arrhythmia (HP:0001692)2.25031823
30Dyschromatopsia (HP:0007641)2.20758836
31Sudden death (HP:0001699)2.16744093
32Abnormality of the ischium (HP:0003174)2.11646184
33Aplasia involving bones of the extremities (HP:0009825)2.11414478
34Aplasia involving bones of the upper limbs (HP:0009823)2.11414478
35Aplasia of the phalanges of the hand (HP:0009802)2.11414478
36Obsessive-compulsive behavior (HP:0000722)2.10820880
37Nephronophthisis (HP:0000090)2.10428749
38Blue irides (HP:0000635)2.09536580
39Megalencephaly (HP:0001355)2.09334512
40Abnormality of the fingertips (HP:0001211)2.08180658
41Hyperventilation (HP:0002883)2.06657159
42Supraventricular tachycardia (HP:0004755)2.05766691
43Supernumerary ribs (HP:0005815)2.04838499
44Subacute progressive viral hepatitis (HP:0006572)2.04789528
45Bronchomalacia (HP:0002780)2.03729152
46Esophageal atresia (HP:0002032)2.03599813
47Truncal obesity (HP:0001956)2.03299638
48Trigonocephaly (HP:0000243)2.02444197
49Exercise-induced muscle cramps (HP:0003710)2.01945313
50Supraventricular arrhythmia (HP:0005115)2.01104467
51Anophthalmia (HP:0000528)1.97113592
52Pancreatic fibrosis (HP:0100732)1.96183545
53Abnormality of the parietal bone (HP:0002696)1.96166103
54Supernumerary bones of the axial skeleton (HP:0009144)1.95329051
55Chronic hepatic failure (HP:0100626)1.94950614
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94755152
57Abnormality of the aortic arch (HP:0012303)1.94384465
58Tracheomalacia (HP:0002779)1.93190788
59Abnormal rod and cone electroretinograms (HP:0008323)1.93180652
60Agitation (HP:0000713)1.90741128
61Abnormality of the renal medulla (HP:0100957)1.90619892
62Pancreatic cysts (HP:0001737)1.90352407
63Abnormality of the pubic bones (HP:0003172)1.88625657
64Focal motor seizures (HP:0011153)1.88162350
65Elfin facies (HP:0004428)1.87309334
66Pendular nystagmus (HP:0012043)1.86165722
67Poor coordination (HP:0002370)1.85413690
68Hyperacusis (HP:0010780)1.82638425
69Heterotopia (HP:0002282)1.81111424
70Type II diabetes mellitus (HP:0005978)1.81054788
71Enlarged penis (HP:0000040)1.80344112
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79709536
73Genetic anticipation (HP:0003743)1.78301744
74Patellar aplasia (HP:0006443)1.76943293
75Vitreoretinal degeneration (HP:0000655)1.75718278
76Renal duplication (HP:0000075)1.74205825
77Oligodactyly (hands) (HP:0001180)1.73534832
78Difficulty running (HP:0009046)1.73157610
79Lip pit (HP:0100267)1.73057203
80Abnormal EKG (HP:0003115)1.72787054
81Increased nuchal translucency (HP:0010880)1.71781134
82Rib fusion (HP:0000902)1.71150546
83Gait imbalance (HP:0002141)1.70901761
84Highly arched eyebrow (HP:0002553)1.70747950
85Abnormality of the parathyroid morphology (HP:0011766)1.70290927
86Proximal amyotrophy (HP:0007126)1.69622858
87Tubulointerstitial nephritis (HP:0001970)1.69511733
88Vaginal atresia (HP:0000148)1.66944489
89Broad-based gait (HP:0002136)1.65477327
90Protruding tongue (HP:0010808)1.65088508
91Genital tract atresia (HP:0001827)1.64313654
92Abnormality of chromosome segregation (HP:0002916)1.64086904
93Abnormality of the nasal septum (HP:0000419)1.63862704
94Postaxial foot polydactyly (HP:0001830)1.63776178
95Syncope (HP:0001279)1.63305985
96Anal stenosis (HP:0002025)1.61954486
97Hepatoblastoma (HP:0002884)1.61524304
98Alacrima (HP:0000522)1.61228494
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60935782
100Short 4th metacarpal (HP:0010044)1.60935782
101Hyporeflexia of lower limbs (HP:0002600)1.59858708
102Exostoses (HP:0100777)1.59203530
103Germ cell neoplasia (HP:0100728)1.59152254
104Gastrointestinal atresia (HP:0002589)1.59019305
105Large for gestational age (HP:0001520)1.58522252
106Molar tooth sign on MRI (HP:0002419)1.57513845
107Abnormality of midbrain morphology (HP:0002418)1.57513845
108Bilateral microphthalmos (HP:0007633)1.56618211
109Abnormality of the 4th metacarpal (HP:0010012)1.56025104
110Attenuation of retinal blood vessels (HP:0007843)1.55770420
111Missing ribs (HP:0000921)1.55490610
112Asymmetry of the thorax (HP:0001555)1.55308056
113Medial flaring of the eyebrow (HP:0010747)1.54999962
114Septo-optic dysplasia (HP:0100842)1.54278509
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.54174851
116Partial agenesis of the corpus callosum (HP:0001338)1.53521062
117Hemiparesis (HP:0001269)1.53013561
11811 pairs of ribs (HP:0000878)1.52589980
119Aplasia/Hypoplasia of the patella (HP:0006498)1.52223951
120Abnormality of the intervertebral disk (HP:0005108)1.52165197
121Cutaneous syndactyly (HP:0012725)1.52140456
122Congenital primary aphakia (HP:0007707)1.52035420
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51493568
124Depressed nasal tip (HP:0000437)1.51289244
125Left ventricular hypertrophy (HP:0001712)1.50797945
126True hermaphroditism (HP:0010459)1.48863785
127Oligodactyly (HP:0012165)1.48594188
128Flat cornea (HP:0007720)1.48062331
129Sex reversal (HP:0012245)1.47835572
130Abnormal sex determination (HP:0012244)1.47835572
131Midline defect of the nose (HP:0004122)1.47184687
132Intestinal atresia (HP:0011100)1.46761037
133Renovascular hypertension (HP:0100817)1.45055332
134Cutaneous finger syndactyly (HP:0010554)1.43757974
135Decreased central vision (HP:0007663)1.43635396
136Scapular winging (HP:0003691)1.43150394
137Limited hip movement (HP:0008800)1.42085629
138Aqueductal stenosis (HP:0002410)1.41402239
139Progressive cerebellar ataxia (HP:0002073)1.41067801
140Thyroid carcinoma (HP:0002890)1.40751881
141Truncal ataxia (HP:0002078)1.40181844
142Colon cancer (HP:0003003)1.40058509
143Pigmentary retinal degeneration (HP:0001146)1.40016397
144Bundle branch block (HP:0011710)1.39846782
145Febrile seizures (HP:0002373)1.39331191
146Abnormality of the diencephalon (HP:0010662)1.39066279
147Pheochromocytoma (HP:0002666)1.38596751
148Narrow palate (HP:0000189)1.38027747
149Dysmetric saccades (HP:0000641)1.37080823
150Hyperinsulinemic hypoglycemia (HP:0000825)1.36941988
151Abnormal ciliary motility (HP:0012262)1.36641769
152Thick eyebrow (HP:0000574)1.36404761
153Epileptic encephalopathy (HP:0200134)1.36160813
154Broad thumb (HP:0011304)1.36151663
155Overriding aorta (HP:0002623)1.35216667
156Morphological abnormality of the middle ear (HP:0008609)1.33989639
157Neonatal short-limb short stature (HP:0008921)1.32627928
158Abolished electroretinogram (ERG) (HP:0000550)1.32600984
159Mask-like facies (HP:0000298)1.32589686
160Cystic liver disease (HP:0006706)1.32215017
161Vertebral arch anomaly (HP:0008438)1.32116910
162Increased corneal curvature (HP:0100692)1.31630683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK22.21781118
2PHKG22.15873240
3PHKG12.15873240
4HIPK22.14423925
5INSRR2.11710237
6CASK2.06327513
7FRK1.87632661
8SGK21.85990387
9LATS11.84497590
10OBSCN1.82385051
11CAMK1G1.80115058
12DMPK1.73600108
13BMPR1B1.73204376
14PRKD31.69742422
15EEF2K1.68274623
16SGK31.65546873
17CDK121.64467822
18MKNK21.64008457
19NTRK21.62759351
20SIK21.55601540
21BRD41.52776672
22MAP3K41.52105207
23TNIK1.48439964
24PNCK1.48371550
25WNK11.43906716
26MUSK1.41311247
27STK391.38513227
28FGFR31.37840391
29ERBB31.34043559
30RIPK11.32981540
31FGFR21.32584482
32NLK1.26565154
33CDC42BPA1.24994034
34UHMK11.24257546
35SGK4941.24175875
36SGK2231.24175875
37TTN1.23788795
38AKT31.22580352
39MAP3K21.22006975
40TRIB31.19286663
41PAK31.18361939
42GRK11.16780208
43NTRK31.16319803
44PDGFRA1.13687061
45PRKD21.12539016
46PKN21.10187689
47CAMK1D1.09935925
48TIE11.07895740
49SIK11.07710928
50MARK11.05034150
51PIK3CA1.02883118
52MKNK11.02545338
53MAPK131.00569039
54WNK31.00221001
55PRKCH0.97266982
56CAMKK10.93909844
57WEE10.91974888
58ICK0.90571599
59CSNK1G20.85724401
60DYRK1B0.84490028
61CDK90.84386259
62MAPK150.83277718
63MAP3K70.81806566
64PTK60.80230294
65PASK0.80161546
66NEK60.80008695
67MAP2K20.79583641
68ROCK10.78957043
69WNK40.78379485
70PRKAA10.78056555
71MAP3K100.77801910
72CDK60.75662258
73CSNK1G10.75125091
74CSNK1A1L0.74720894
75SGK10.74399026
76FGFR40.74345859
77TYRO30.73724985
78MAP2K40.72983610
79RET0.72643883
80EPHA30.71275087
81PRKD10.70057831
82ATR0.68872435
83MTOR0.68364662
84RPS6KB20.66975725
85NEK10.65712503
86CDK80.65296260
87DDR20.64673028
88CDC70.64526392
89FGFR10.64385387
90TAF10.63935271
91CSNK1G30.62824202
92ERBB20.62062176
93CAMK40.61537393
94MAPKAPK50.61220909
95STK240.60691637
96MAPK110.58870970
97MELK0.58005096
98MAPK140.57777539
99RPS6KB10.57761263
100ALK0.57517940
101RPS6KA30.57392382
102AKT20.57363819
103CDK70.56917465
104NEK20.56708955
105CDK20.56573878
106PRKAA20.56503877
107PINK10.55871953
108ZAK0.55787859
109CSNK1D0.54758759
110NUAK10.54358346
111TGFBR10.54243559
112CHEK20.53713231
113CDK40.53232626
114SCYL20.53059826
115CAMK2D0.52859362
116CAMK10.52812640
117CDK30.51541615
118CDK10.50606919
119GSK3B0.49714460
120MARK20.49641602
121PRKDC0.49601587
122CSNK1E0.49367175
123DYRK1A0.49220785
124STK110.49180583
125MAPK100.48482181
126AKT10.48456572
127RPS6KA20.48049731
128STK380.47765878
129TLK10.47363020
130ATM0.47220419
131EPHA40.45862046
132CHUK0.45614005
133DYRK20.45193454
134NME10.42391317
135MAPK80.42351734

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.61797385
2Dilated cardiomyopathy_Homo sapiens_hsa054142.00194313
3Insulin secretion_Homo sapiens_hsa049111.98289542
4Olfactory transduction_Homo sapiens_hsa047401.81221454
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75796466
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74561632
7Circadian rhythm_Homo sapiens_hsa047101.69753963
8Circadian entrainment_Homo sapiens_hsa047131.67269466
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67064212
10Cocaine addiction_Homo sapiens_hsa050301.55453724
11GABAergic synapse_Homo sapiens_hsa047271.51829297
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.49276925
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49218937
14Gastric acid secretion_Homo sapiens_hsa049711.47806457
15Amphetamine addiction_Homo sapiens_hsa050311.47368742
16Dopaminergic synapse_Homo sapiens_hsa047281.43404602
17cGMP-PKG signaling pathway_Homo sapiens_hsa040221.41822793
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38618735
19Cholinergic synapse_Homo sapiens_hsa047251.36385135
20Basal cell carcinoma_Homo sapiens_hsa052171.35366497
21Renin secretion_Homo sapiens_hsa049241.34635548
22Glutamatergic synapse_Homo sapiens_hsa047241.32637683
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32068631
24Long-term potentiation_Homo sapiens_hsa047201.31272429
25Dorso-ventral axis formation_Homo sapiens_hsa043201.29482622
26Wnt signaling pathway_Homo sapiens_hsa043101.26330307
27Cardiac muscle contraction_Homo sapiens_hsa042601.25722014
28Melanogenesis_Homo sapiens_hsa049161.24576282
29Type II diabetes mellitus_Homo sapiens_hsa049301.22510889
30Salivary secretion_Homo sapiens_hsa049701.21505472
31Morphine addiction_Homo sapiens_hsa050321.20435301
32Taste transduction_Homo sapiens_hsa047421.20204512
33Oxytocin signaling pathway_Homo sapiens_hsa049211.18711277
34Alcoholism_Homo sapiens_hsa050341.18168554
35Glucagon signaling pathway_Homo sapiens_hsa049221.17399053
36Endometrial cancer_Homo sapiens_hsa052131.16113581
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15398132
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13756888
39mTOR signaling pathway_Homo sapiens_hsa041501.13173205
40Hedgehog signaling pathway_Homo sapiens_hsa043401.12221342
41cAMP signaling pathway_Homo sapiens_hsa040241.11230841
42Nitrogen metabolism_Homo sapiens_hsa009101.11015146
43Lysine degradation_Homo sapiens_hsa003101.10231810
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08436533
45Estrogen signaling pathway_Homo sapiens_hsa049151.06665105
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05717145
47Serotonergic synapse_Homo sapiens_hsa047261.05291154
48Glioma_Homo sapiens_hsa052141.04901713
49Hippo signaling pathway_Homo sapiens_hsa043901.04377670
50Thyroid hormone synthesis_Homo sapiens_hsa049181.02141415
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01733159
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01721497
53Gap junction_Homo sapiens_hsa045401.01078563
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00570647
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00181056
56Adherens junction_Homo sapiens_hsa045200.99216523
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98952575
58Nicotine addiction_Homo sapiens_hsa050330.98353113
59Focal adhesion_Homo sapiens_hsa045100.98211210
60Calcium signaling pathway_Homo sapiens_hsa040200.95783397
61Tight junction_Homo sapiens_hsa045300.94658162
62Colorectal cancer_Homo sapiens_hsa052100.94631760
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.94241262
64Butanoate metabolism_Homo sapiens_hsa006500.93484021
65GnRH signaling pathway_Homo sapiens_hsa049120.92629220
66Long-term depression_Homo sapiens_hsa047300.91809995
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90262007
68Insulin signaling pathway_Homo sapiens_hsa049100.89355009
69Proteoglycans in cancer_Homo sapiens_hsa052050.88525746
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.87954482
71ErbB signaling pathway_Homo sapiens_hsa040120.87464797
72Insulin resistance_Homo sapiens_hsa049310.86645908
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86258903
74Notch signaling pathway_Homo sapiens_hsa043300.85950023
75MicroRNAs in cancer_Homo sapiens_hsa052060.85532409
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.84177881
77Prostate cancer_Homo sapiens_hsa052150.83712881
78Thyroid cancer_Homo sapiens_hsa052160.83507699
79Pancreatic secretion_Homo sapiens_hsa049720.83233388
80Pancreatic cancer_Homo sapiens_hsa052120.82813870
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81729071
82Non-small cell lung cancer_Homo sapiens_hsa052230.81415247
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80697571
84Fanconi anemia pathway_Homo sapiens_hsa034600.80627819
85Chronic myeloid leukemia_Homo sapiens_hsa052200.79136525
86Inositol phosphate metabolism_Homo sapiens_hsa005620.78441326
87AMPK signaling pathway_Homo sapiens_hsa041520.78425681
88ECM-receptor interaction_Homo sapiens_hsa045120.78191071
89MAPK signaling pathway_Homo sapiens_hsa040100.77219804
90Fatty acid biosynthesis_Homo sapiens_hsa000610.76276071
91Renal cell carcinoma_Homo sapiens_hsa052110.75184927
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74916264
93Ovarian steroidogenesis_Homo sapiens_hsa049130.74660423
94ABC transporters_Homo sapiens_hsa020100.74440991
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74188501
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72107715
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71496438
98Spliceosome_Homo sapiens_hsa030400.71356172
99Prolactin signaling pathway_Homo sapiens_hsa049170.70911749
100FoxO signaling pathway_Homo sapiens_hsa040680.70891063
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69942484
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.69370496
103Axon guidance_Homo sapiens_hsa043600.69085884
104Melanoma_Homo sapiens_hsa052180.67956868
105Synaptic vesicle cycle_Homo sapiens_hsa047210.66423356
106* mRNA surveillance pathway_Homo sapiens_hsa030150.66073775
107Cell cycle_Homo sapiens_hsa041100.65478057
108Pathways in cancer_Homo sapiens_hsa052000.65012684
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.64825017
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64569326
111VEGF signaling pathway_Homo sapiens_hsa043700.64334790
112TGF-beta signaling pathway_Homo sapiens_hsa043500.63662817
113Rap1 signaling pathway_Homo sapiens_hsa040150.62976942
114Choline metabolism in cancer_Homo sapiens_hsa052310.62696867

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