MSI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)9.34892474
2spindle assembly involved in mitosis (GO:0090307)5.79016018
3anterior/posterior axis specification, embryo (GO:0008595)5.34569739
4lung-associated mesenchyme development (GO:0060484)4.96226313
5regulation of rhodopsin mediated signaling pathway (GO:0022400)4.89895256
6photoreceptor cell maintenance (GO:0045494)4.88465367
7photoreceptor cell development (GO:0042461)4.81028517
8positive regulation of mitochondrial fission (GO:0090141)4.80317220
9rhodopsin mediated signaling pathway (GO:0016056)4.78470447
10retinal cone cell development (GO:0046549)4.68631382
11prostate gland growth (GO:0060736)4.66414016
12microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.52408648
13eye photoreceptor cell development (GO:0042462)4.52131055
14lateral sprouting from an epithelium (GO:0060601)4.49732848
15positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.42876439
16peripheral nervous system axon ensheathment (GO:0032292)4.37830678
17myelination in peripheral nervous system (GO:0022011)4.37830678
18regulation of tight junction assembly (GO:2000810)4.36434626
19planar cell polarity pathway involved in neural tube closure (GO:0090179)4.31202162
20centrosome duplication (GO:0051298)4.30429167
21negative regulation of Rho protein signal transduction (GO:0035024)4.29327164
22regulation of cell proliferation involved in kidney development (GO:1901722)4.26279628
23paraxial mesoderm development (GO:0048339)4.17206844
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.11843473
25retinal rod cell development (GO:0046548)4.05518123
26neuronal stem cell maintenance (GO:0097150)4.02749194
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.94856119
28NADH dehydrogenase complex assembly (GO:0010257)3.94856119
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94856119
30behavioral response to nicotine (GO:0035095)3.84502525
31cell differentiation involved in embryonic placenta development (GO:0060706)3.82070432
32cell migration in hindbrain (GO:0021535)3.78899295
33DNA replication checkpoint (GO:0000076)3.77680226
34establishment of planar polarity (GO:0001736)3.73121340
35establishment of tissue polarity (GO:0007164)3.73121340
36mitochondrion morphogenesis (GO:0070584)3.69996488
37positive regulation of gastrulation (GO:2000543)3.64953914
38retina development in camera-type eye (GO:0060041)3.64017980
39regulation of translational termination (GO:0006449)3.63294568
40thalamus development (GO:0021794)3.61733076
41positive regulation of oligodendrocyte differentiation (GO:0048714)3.61151347
42embryonic camera-type eye development (GO:0031076)3.60776524
43regulation of mitochondrial fission (GO:0090140)3.58383722
44regulation of energy homeostasis (GO:2000505)3.57718834
45ventricular septum development (GO:0003281)3.54689621
46presynaptic membrane assembly (GO:0097105)3.54469112
47regulation of NFAT protein import into nucleus (GO:0051532)3.50542693
48endocardial cushion morphogenesis (GO:0003203)3.49179122
49phototransduction (GO:0007602)3.49093619
50axonal fasciculation (GO:0007413)3.47612837
51layer formation in cerebral cortex (GO:0021819)3.46699027
52protein insertion into membrane (GO:0051205)3.43538881
53G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.43144700
54serine family amino acid catabolic process (GO:0009071)3.41468172
55mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.41293439
56eye photoreceptor cell differentiation (GO:0001754)3.41164015
57photoreceptor cell differentiation (GO:0046530)3.41164015
58protein complex biogenesis (GO:0070271)3.37423207
59negative regulation of kidney development (GO:0090185)3.33948158
60visual perception (GO:0007601)3.32372852
61phototransduction, visible light (GO:0007603)3.31040649
62sensory perception of light stimulus (GO:0050953)3.30396191
63bicarbonate transport (GO:0015701)3.29395129
64preassembly of GPI anchor in ER membrane (GO:0016254)3.29006292
65detection of light stimulus (GO:0009583)3.28523491
66glycine metabolic process (GO:0006544)3.28346929
67gland morphogenesis (GO:0022612)3.27539709
68mitochondrial respiratory chain complex assembly (GO:0033108)3.25090127
69presynaptic membrane organization (GO:0097090)3.23505868
70epithelial cell fate commitment (GO:0072148)3.22565933
71neuron fate determination (GO:0048664)3.21994018
72detection of visible light (GO:0009584)3.21773012
73detection of light stimulus involved in sensory perception (GO:0050962)3.21222507
74detection of light stimulus involved in visual perception (GO:0050908)3.21222507
75viral transcription (GO:0019083)3.19199200
76inner cell mass cell proliferation (GO:0001833)3.13707876
77epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.10395119
78mesenchyme morphogenesis (GO:0072132)3.10063623
79translational termination (GO:0006415)3.09386011
80organ growth (GO:0035265)3.08483358
81negative regulation of oligodendrocyte differentiation (GO:0048715)3.07367494
82synapsis (GO:0007129)3.06402779
83protein-DNA complex disassembly (GO:0032986)3.05192028
84nucleosome disassembly (GO:0006337)3.05192028
85nonmotile primary cilium assembly (GO:0035058)3.04756681
86response to pheromone (GO:0019236)3.04315223
87limb bud formation (GO:0060174)3.03766171
88convergent extension (GO:0060026)3.01425109
89regulation of translational elongation (GO:0006448)3.00155246
90pyrimidine nucleobase catabolic process (GO:0006208)2.98218498
91maturation of SSU-rRNA (GO:0030490)2.97286888
92mitochondrial fusion (GO:0008053)2.93994401
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92659201
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92647922
95peroxisome fission (GO:0016559)2.92258627
96embryonic foregut morphogenesis (GO:0048617)2.91858545
97central nervous system projection neuron axonogenesis (GO:0021952)2.91302721
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.90599858
99positive regulation of neuroblast proliferation (GO:0002052)2.88908585
100cochlea morphogenesis (GO:0090103)2.88524448
101Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.88443539
102positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.88335920
103hippocampus development (GO:0021766)2.87202511
104midbrain development (GO:0030901)2.86746218
105dendritic spine morphogenesis (GO:0060997)2.86618489
106negative regulation of glycogen biosynthetic process (GO:0045719)2.85727715
107water-soluble vitamin biosynthetic process (GO:0042364)2.84128180
108neuron recognition (GO:0008038)2.83738720
109mitotic spindle organization (GO:0007052)2.83734345
110regulation of establishment of planar polarity (GO:0090175)2.82866886
111regulation of inositol phosphate biosynthetic process (GO:0010919)2.82438120
112glial cell proliferation (GO:0014009)2.82292947
113regulation of somitogenesis (GO:0014807)2.81871762
114DNA deamination (GO:0045006)2.77907052
115regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.76745672
116cell proliferation in forebrain (GO:0021846)2.76692662
117cardiac septum development (GO:0003279)2.75699982
118regulation of development, heterochronic (GO:0040034)2.74960981
119GMP metabolic process (GO:0046037)2.74842070
120somite rostral/caudal axis specification (GO:0032525)2.74422534
121spinal cord development (GO:0021510)2.74157836
122regulation of mesenchymal cell apoptotic process (GO:2001053)2.71832036
123negative regulation of telomerase activity (GO:0051974)2.70183033
124primitive streak formation (GO:0090009)2.69934495
125positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68913992
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.67409795
127pre-miRNA processing (GO:0031054)2.66801861
128labyrinthine layer blood vessel development (GO:0060716)2.66431393
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65763761
130chromosome organization involved in meiosis (GO:0070192)2.65064187
131lens fiber cell development (GO:0070307)2.64332176
132embryonic axis specification (GO:0000578)2.64331671
133negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64303069
134artery development (GO:0060840)2.63463109
135chromatin remodeling at centromere (GO:0031055)2.63335177
136translational elongation (GO:0006414)2.63006606
137protein-chromophore linkage (GO:0018298)2.62772038
138retinal ganglion cell axon guidance (GO:0031290)2.61723221
139hindlimb morphogenesis (GO:0035137)2.61650801
140lung epithelium development (GO:0060428)2.59292490
141proximal/distal pattern formation (GO:0009954)2.59077701
142non-canonical Wnt signaling pathway (GO:0035567)2.58486907
143male sex determination (GO:0030238)2.58050385
144retina layer formation (GO:0010842)2.57483421
145urogenital system development (GO:0001655)2.57258565
146regulation of nuclear cell cycle DNA replication (GO:0033262)2.56790939
147nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56379971
148positive regulation of RNA splicing (GO:0033120)2.56101260
149negative regulation of axon guidance (GO:1902668)2.55951849
150innervation (GO:0060384)2.55506293
151T cell lineage commitment (GO:0002360)2.55113514
152establishment of protein localization to mitochondrial membrane (GO:0090151)2.55081546
153heart valve formation (GO:0003188)2.54863612
154spliceosomal tri-snRNP complex assembly (GO:0000244)2.54707215
155forebrain neuron differentiation (GO:0021879)2.54636567
156dopaminergic neuron differentiation (GO:0071542)2.54496568
157tongue development (GO:0043586)2.54344153
158collecting duct development (GO:0072044)2.54304659
159heterochromatin organization (GO:0070828)2.53437524
160dentate gyrus development (GO:0021542)2.53110818
161protein K6-linked ubiquitination (GO:0085020)2.52803969
162chaperone-mediated protein transport (GO:0072321)2.52636237
163apical protein localization (GO:0045176)2.52195149
164negative regulation of axon extension involved in axon guidance (GO:0048843)2.51740725
165CENP-A containing nucleosome assembly (GO:0034080)2.51271662
166Notch signaling involved in heart development (GO:0061314)2.50632459
167positive regulation of male gonad development (GO:2000020)2.50587091
168negative regulation of astrocyte differentiation (GO:0048712)2.49396204
169negative regulation of catenin import into nucleus (GO:0035414)2.48763868
170otic vesicle formation (GO:0030916)2.48444844
171somite development (GO:0061053)2.48282661
172negative regulation of mRNA processing (GO:0050686)2.47413572
173cranial nerve morphogenesis (GO:0021602)2.47225195
174CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.46819638
175positive regulation of fatty acid oxidation (GO:0046321)2.46276044
176notochord development (GO:0030903)2.45471714
177neuron fate specification (GO:0048665)2.45421572
178regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45150322
179regulation of DNA endoreduplication (GO:0032875)2.44299847
180atrial cardiac muscle cell action potential (GO:0086014)2.43527499
181synaptonemal complex assembly (GO:0007130)2.43309009
182peptidyl-arginine omega-N-methylation (GO:0035247)2.42069925
183lens morphogenesis in camera-type eye (GO:0002089)2.41105368
184hindbrain development (GO:0030902)2.40781981
185negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40752137
186replicative senescence (GO:0090399)2.39581614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62726334
2TP63_19390658_ChIP-ChIP_HaCaT_Human2.98266741
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.80335576
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60650532
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57731948
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57055765
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46613079
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46613079
9E2F7_22180533_ChIP-Seq_HELA_Human2.46561674
10FUS_26573619_Chip-Seq_HEK293_Human2.46053041
11RNF2_27304074_Chip-Seq_ESCs_Mouse2.45299089
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.36012720
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.35722278
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35091888
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.30120943
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29014312
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23022424
18* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22373875
19RING1B_27294783_Chip-Seq_NPCs_Mouse2.21778044
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18687477
21MYC_18940864_ChIP-ChIP_HL60_Human2.18462163
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12520312
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11054281
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07765968
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.06999324
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04952574
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99485088
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97368525
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93100039
30RING1B_27294783_Chip-Seq_ESCs_Mouse1.92187595
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90546156
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90418828
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89439283
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.89162023
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88115445
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.87931663
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85260949
38* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.84476864
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.83095637
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81418237
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80241886
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77113263
43RNF2_27304074_Chip-Seq_NSC_Mouse1.73001584
44ZNF274_21170338_ChIP-Seq_K562_Hela1.69654583
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68480660
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64464429
47EWS_26573619_Chip-Seq_HEK293_Human1.63240945
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58823474
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57666919
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57082779
51* KDM2B_26808549_Chip-Seq_K562_Human1.56376145
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54023255
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53100117
54CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.52364497
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.48633500
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.48371476
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46670091
58GBX2_23144817_ChIP-Seq_PC3_Human1.46504001
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43477532
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.42814891
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.42113040
62TTF2_22483619_ChIP-Seq_HELA_Human1.41544680
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.41388979
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40061892
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39069520
66* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37557948
67REST_21632747_ChIP-Seq_MESCs_Mouse1.36816429
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36795363
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33794587
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32598988
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31746890
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31052969
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30062619
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29814231
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28618202
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28501817
77DROSHA_22980978_ChIP-Seq_HELA_Human1.28163922
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27051097
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26018735
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.25613016
81IRF1_19129219_ChIP-ChIP_H3396_Human1.24252644
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22184069
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22184069
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22184069
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21607416
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21580818
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.21574919
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21314690
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20546158
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17894878
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15161204
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14908091
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.14527407
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.12817323
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12214076
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12121972
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.10715117
98XRN2_22483619_ChIP-Seq_HELA_Human1.09817751
99CTCF_27219007_Chip-Seq_Bcells_Human1.08687923
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08279803
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06935196
102TAF15_26573619_Chip-Seq_HEK293_Human1.06611890
103SOX3_22085726_ChIP-Seq_NPCs_Mouse1.06591791
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06582610
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06129643
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05831376
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04223842
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04196228
109NANOG_21062744_ChIP-ChIP_HESCs_Human1.03375762
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03361674
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02479173
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01537577
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01383392
114WDR5_24793694_ChIP-Seq_LNCAP_Human1.00949846
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99855629
116IGF1R_20145208_ChIP-Seq_DFB_Human0.99206436
117ETS1_20019798_ChIP-Seq_JURKAT_Human0.98416872
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98238172
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97685512
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97680439
121P300_19829295_ChIP-Seq_ESCs_Human0.97324622
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96384004
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.96242942
124CREB1_26743006_Chip-Seq_LNCaP_Human0.95708575
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94911547
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94911547
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94750009
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94211620
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94200729
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93715717
131AR_19668381_ChIP-Seq_PC3_Human0.93284641
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92647222
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.92623857
134* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92621102
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92159193
136* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91412004
137IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90246928
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89239026
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89167090
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89073220
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.88594148
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88554524
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87763574
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87538349
145NCOR_22424771_ChIP-Seq_293T_Human0.84450549
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84370738
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83861154
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83244052
149SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82444582
150NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81105910
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80964749
152SOX9_26525672_Chip-Seq_HEART_Mouse0.80653215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.00717888
2MP0005551_abnormal_eye_electrophysiolog3.67339665
3MP0003011_delayed_dark_adaptation3.59393015
4MP0006072_abnormal_retinal_apoptosis3.54745896
5MP0003656_abnormal_erythrocyte_physiolo3.44186354
6MP0009379_abnormal_foot_pigmentation3.26219338
7MP0005253_abnormal_eye_physiology3.13135547
8MP0006292_abnormal_olfactory_placode3.07004104
9MP0005367_renal/urinary_system_phenotyp3.01076789
10MP0000516_abnormal_urinary_system3.01076789
11MP0008789_abnormal_olfactory_epithelium3.00015629
12MP0005394_taste/olfaction_phenotype2.79424198
13MP0005499_abnormal_olfactory_system2.79424198
14MP0003693_abnormal_embryo_hatching2.63764734
15* MP0000778_abnormal_nervous_system2.39326894
16* MP0002653_abnormal_ependyma_morphology2.31101428
17MP0000566_synostosis2.26565858
18MP0005391_vision/eye_phenotype2.16496540
19MP0005195_abnormal_posterior_eye2.15158029
20MP0001188_hyperpigmentation2.11865310
21MP0005423_abnormal_somatic_nervous2.02692888
22MP0008872_abnormal_physiological_respon2.01802076
23MP0000049_abnormal_middle_ear2.01008033
24MP0000537_abnormal_urethra_morphology1.97968071
25MP0003111_abnormal_nucleus_morphology1.81063611
26MP0001849_ear_inflammation1.80891275
27MP0005248_abnormal_Harderian_gland1.79965126
28MP0003890_abnormal_embryonic-extraembry1.72308369
29MP0000631_abnormal_neuroendocrine_gland1.71125839
30MP0002234_abnormal_pharynx_morphology1.70841761
31MP0003122_maternal_imprinting1.69238788
32MP0002752_abnormal_somatic_nervous1.66864240
33MP0009053_abnormal_anal_canal1.65360079
34MP0001293_anophthalmia1.62324524
35MP0003119_abnormal_digestive_system1.61552794
36MP0001324_abnormal_eye_pigmentation1.61400977
37MP0002697_abnormal_eye_size1.61355811
38MP0002638_abnormal_pupillary_reflex1.60353051
39MP0003283_abnormal_digestive_organ1.58983729
40MP0000428_abnormal_craniofacial_morphol1.56262789
41MP0005670_abnormal_white_adipose1.53399640
42MP0001286_abnormal_eye_development1.52814112
43MP0002751_abnormal_autonomic_nervous1.52703758
44MP0002160_abnormal_reproductive_system1.51396167
45* MP0003861_abnormal_nervous_system1.50972464
46MP0009765_abnormal_xenobiotic_induced1.48839558
47MP0004885_abnormal_endolymph1.48155489
48MP0003942_abnormal_urinary_system1.47730518
49MP0003121_genomic_imprinting1.47282913
50MP0001984_abnormal_olfaction1.42976079
51MP0002233_abnormal_nose_morphology1.42007622
52MP0002882_abnormal_neuron_morphology1.41628685
53MP0002282_abnormal_trachea_morphology1.40036445
54MP0002249_abnormal_larynx_morphology1.39107270
55MP0000026_abnormal_inner_ear1.38822825
56MP0002938_white_spotting1.34843595
57MP0002102_abnormal_ear_morphology1.33891805
58MP0003755_abnormal_palate_morphology1.33786291
59MP0005187_abnormal_penis_morphology1.33764857
60MP0010094_abnormal_chromosome_stability1.33428768
61MP0003938_abnormal_ear_development1.32918730
62MP0003385_abnormal_body_wall1.29660027
63MP0003315_abnormal_perineum_morphology1.28675547
64MP0008995_early_reproductive_senescence1.26990465
65* MP0002116_abnormal_craniofacial_bone1.25337755
66MP0003115_abnormal_respiratory_system1.21694068
67MP0002092_abnormal_eye_morphology1.20894395
68MP0004233_abnormal_muscle_weight1.19256629
69MP0001502_abnormal_circadian_rhythm1.18993463
70MP0002184_abnormal_innervation1.17976935
71MP0001346_abnormal_lacrimal_gland1.15514453
72MP0003935_abnormal_craniofacial_develop1.15480848
73* MP0002152_abnormal_brain_morphology1.14470663
74MP0000013_abnormal_adipose_tissue1.13947496
75MP0002932_abnormal_joint_morphology1.13754821
76MP0008877_abnormal_DNA_methylation1.11101057
77MP0003937_abnormal_limbs/digits/tail_de1.10340948
78MP0000534_abnormal_ureter_morphology1.08046925
79MP0003878_abnormal_ear_physiology1.07890459
80MP0005377_hearing/vestibular/ear_phenot1.07890459
81MP0003718_maternal_effect1.06161330
82MP0004859_abnormal_synaptic_plasticity1.05686347
83MP0001529_abnormal_vocalization1.04759202
84MP0000955_abnormal_spinal_cord1.02115435
85MP0004133_heterotaxia1.01000827
86MP0005076_abnormal_cell_differentiation0.99844563
87MP0001270_distended_abdomen0.98808285
88MP0005623_abnormal_meninges_morphology0.98288111
89MP0002085_abnormal_embryonic_tissue0.97174194
90MP0001486_abnormal_startle_reflex0.96613925
91MP0001756_abnormal_urination0.95905482
92MP0008961_abnormal_basal_metabolism0.95776254
93MP0008932_abnormal_embryonic_tissue0.93831893
94MP0009250_abnormal_appendicular_skeleto0.93122861
95MP0002229_neurodegeneration0.92291373
96MP0003136_yellow_coat_color0.91906747
97MP0003880_abnormal_central_pattern0.91265293
98MP0002557_abnormal_social/conspecific_i0.91228078
99MP0002081_perinatal_lethality0.91182499
100MP0003936_abnormal_reproductive_system0.90852844
101MP0001485_abnormal_pinna_reflex0.89873632
102MP0003123_paternal_imprinting0.89847682
103MP0002089_abnormal_postnatal_growth/wei0.89476473
104MP0002095_abnormal_skin_pigmentation0.88305990
105MP0008770_decreased_survivor_rate0.88183616
106MP0001299_abnormal_eye_distance/0.87510455
107MP0002277_abnormal_respiratory_mucosa0.86895506
108MP0008007_abnormal_cellular_replicative0.85295055
109MP0003787_abnormal_imprinting0.85068150
110MP0005197_abnormal_uvea_morphology0.84672534
111MP0001963_abnormal_hearing_physiology0.83745326
112MP0002084_abnormal_developmental_patter0.83157810
113MP0002090_abnormal_vision0.81063539
114MP0009046_muscle_twitch0.80279341
115MP0005389_reproductive_system_phenotype0.79905557
116MP0002572_abnormal_emotion/affect_behav0.79868145
117MP0002063_abnormal_learning/memory/cond0.79821277
118MP0005645_abnormal_hypothalamus_physiol0.78881895
119MP0004270_analgesia0.78869830
120MP0002132_abnormal_respiratory_system0.78383472
121MP0000432_abnormal_head_morphology0.77836310
122MP0002210_abnormal_sex_determination0.77535629
123MP0003635_abnormal_synaptic_transmissio0.76423837
124MP0009384_cardiac_valve_regurgitation0.76417209
125MP0004811_abnormal_neuron_physiology0.75952333
126MP0002111_abnormal_tail_morphology0.75059289
127MP0005174_abnormal_tail_pigmentation0.73940975
128MP0005646_abnormal_pituitary_gland0.72175199
129MP0004742_abnormal_vestibular_system0.72123392
130MP0002928_abnormal_bile_duct0.71543480
131MP0006276_abnormal_autonomic_nervous0.70665046
132MP0004197_abnormal_fetal_growth/weight/0.70255648
133MP0004858_abnormal_nervous_system0.70166286
134MP0002064_seizures0.69908016
135MP0002114_abnormal_axial_skeleton0.67954657
136MP0000762_abnormal_tongue_morphology0.66658400

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)9.32702380
2Acanthocytosis (HP:0001927)7.66340344
3Pendular nystagmus (HP:0012043)5.90906318
4Congenital stationary night blindness (HP:0007642)5.85893516
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.67391852
6Bony spicule pigmentary retinopathy (HP:0007737)5.29444187
7Chorioretinal atrophy (HP:0000533)5.27641025
8Abnormal rod and cone electroretinograms (HP:0008323)5.16049216
9Short 1st metacarpal (HP:0010034)4.99706950
10Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.99706950
11Central scotoma (HP:0000603)4.80015110
12Stenosis of the external auditory canal (HP:0000402)4.75552918
13Paralysis (HP:0003470)4.69457118
14Ectopic kidney (HP:0000086)4.51583861
15Abnormality of the 1st metacarpal (HP:0010009)4.38134950
16Scotoma (HP:0000575)4.36801602
17Abolished electroretinogram (ERG) (HP:0000550)4.27061460
18Dyschromatopsia (HP:0007641)4.10003082
19Severe visual impairment (HP:0001141)3.97754438
20Reticulocytopenia (HP:0001896)3.96646430
21Rectal fistula (HP:0100590)3.85756789
22Rectovaginal fistula (HP:0000143)3.85756789
23Posterior subcapsular cataract (HP:0007787)3.85063100
24Renal tubular acidosis (HP:0001947)3.84976617
25Carpal bone hypoplasia (HP:0001498)3.82416733
26Pigmentary retinal degeneration (HP:0001146)3.81908629
27Abnormality of macular pigmentation (HP:0008002)3.79658072
28Absent thumb (HP:0009777)3.74014211
29Vitreoretinal degeneration (HP:0000655)3.70641868
30Duplicated collecting system (HP:0000081)3.62007566
31Short phalanx of the thumb (HP:0009660)3.56301965
32Decreased central vision (HP:0007663)3.54448191
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45018422
34Abnormality of reticulocytes (HP:0004312)3.41796680
35Intestinal fistula (HP:0100819)3.41038924
36Abnormality of the renal collecting system (HP:0004742)3.39938175
37Abnormality of the parathyroid morphology (HP:0011766)3.34514713
38Keratoconus (HP:0000563)3.31226693
39Increased corneal curvature (HP:0100692)3.31226693
40Chromsome breakage (HP:0040012)3.27323711
41Vaginal fistula (HP:0004320)3.22679399
42Type II diabetes mellitus (HP:0005978)3.19647657
43Reticulocytosis (HP:0001923)3.15815219
44Attenuation of retinal blood vessels (HP:0007843)3.14485911
45Optic nerve coloboma (HP:0000588)3.05919021
46Rickets (HP:0002748)2.98289034
47Absent radius (HP:0003974)2.94803561
48Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.93311692
49Short hallux (HP:0010109)2.91113279
50Horseshoe kidney (HP:0000085)2.87332645
51Absent forearm bone (HP:0003953)2.87185563
52Aplasia involving forearm bones (HP:0009822)2.87185563
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.83501782
54Renal duplication (HP:0000075)2.80764013
55Abnormal number of incisors (HP:0011064)2.75053458
56Abnormality of DNA repair (HP:0003254)2.73937713
57Septo-optic dysplasia (HP:0100842)2.72771900
58Photophobia (HP:0000613)2.72060766
59Poikilocytosis (HP:0004447)2.71161529
60Short thumb (HP:0009778)2.71150972
61Triphalangeal thumb (HP:0001199)2.70046484
62Aplasia/Hypoplasia of the hallux (HP:0008362)2.69901669
63Macular degeneration (HP:0000608)2.69719518
64Anophthalmia (HP:0000528)2.67740965
65Pathologic fracture (HP:0002756)2.62427422
66Synostosis of carpal bones (HP:0005048)2.61788294
67Cone-rod dystrophy (HP:0000548)2.49583474
68Fused cervical vertebrae (HP:0002949)2.47396385
69Neoplasm of the oral cavity (HP:0100649)2.45243447
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44786342
71Short 4th metacarpal (HP:0010044)2.44786342
72Aplasia/Hypoplasia involving the musculature (HP:0001460)2.42905165
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.41219775
74Duplication of thumb phalanx (HP:0009942)2.39057077
75Renal tubular dysfunction (HP:0000124)2.35470188
76Meckel diverticulum (HP:0002245)2.33705705
77Bilateral microphthalmos (HP:0007633)2.31685255
78Elfin facies (HP:0004428)2.27854911
79Midline defect of the nose (HP:0004122)2.25976485
80Abnormality of the ileum (HP:0001549)2.25174020
81Constricted visual fields (HP:0001133)2.24462025
82Abnormality of the diencephalon (HP:0010662)2.23096000
83Hyperacusis (HP:0010780)2.22511557
84Abnormality of the carotid arteries (HP:0005344)2.22260327
85Anal stenosis (HP:0002025)2.19441601
86Increased nuchal translucency (HP:0010880)2.19069179
87Renovascular hypertension (HP:0100817)2.14937387
88Status epilepticus (HP:0002133)2.13556732
89Preaxial foot polydactyly (HP:0001841)2.12344545
90Maternal diabetes (HP:0009800)2.08650457
91True hermaphroditism (HP:0010459)2.07857744
92Subcapsular cataract (HP:0000523)2.07565517
93Retinitis pigmentosa (HP:0000510)2.06571682
94Overriding aorta (HP:0002623)2.06451608
95High anterior hairline (HP:0009890)2.05074681
96Abnormality of abdominal situs (HP:0011620)2.04705221
97Abdominal situs inversus (HP:0003363)2.04705221
98Esotropia (HP:0000565)2.04529847
99Insomnia (HP:0100785)2.03473442
100Abnormality of cochlea (HP:0000375)2.03393228
101Metabolic acidosis (HP:0001942)1.99969152
102Birth length less than 3rd percentile (HP:0003561)1.98833529
103Pancreatic cysts (HP:0001737)1.98665552
104Choanal stenosis (HP:0000452)1.98518836
105Trigonocephaly (HP:0000243)1.97136104
106Tachypnea (HP:0002789)1.94230771
107Morphological abnormality of the inner ear (HP:0011390)1.93996768
108Oligodactyly (HP:0012165)1.93937607
109Aplasia/hypoplasia of the humerus (HP:0006507)1.92880486
110Sclerocornea (HP:0000647)1.92434152
111Abnormality of midbrain morphology (HP:0002418)1.92196508
112Molar tooth sign on MRI (HP:0002419)1.92196508
113Short humerus (HP:0005792)1.90624567
114Choroideremia (HP:0001139)1.90443987
115Abnormality of the aortic arch (HP:0012303)1.89601876
116Carpal synostosis (HP:0009702)1.88595285
117Hypoplasia of the ulna (HP:0003022)1.87207923
118Acute necrotizing encephalopathy (HP:0006965)1.86005068
119Hypoplasia of the radius (HP:0002984)1.85897274
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84977949
121Hepatoblastoma (HP:0002884)1.82135666
122Intestinal atresia (HP:0011100)1.81997662
123Abnormal number of erythroid precursors (HP:0012131)1.80480846
124Abnormality of chromosome stability (HP:0003220)1.80118253
125Nephrocalcinosis (HP:0000121)1.78502749
126Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77207261
127Abnormality of the 4th metacarpal (HP:0010012)1.76787641
128Absent/shortened dynein arms (HP:0200106)1.76579076
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.76579076
130Sex reversal (HP:0012245)1.76123794
131Abnormal sex determination (HP:0012244)1.76123794
132Renal agenesis (HP:0000104)1.75050132
133Hypocalcemia (HP:0002901)1.74486210
134Bifid tongue (HP:0010297)1.73838478
135Duodenal stenosis (HP:0100867)1.73794323
136Small intestinal stenosis (HP:0012848)1.73794323
137Flat cornea (HP:0007720)1.71598180
138Vertebral fusion (HP:0002948)1.70800967
139Concave nail (HP:0001598)1.70251934
140Congenital primary aphakia (HP:0007707)1.69740272
141Esophageal atresia (HP:0002032)1.69670904
142Wide nasal bridge (HP:0000431)1.69573289
143Spina bifida occulta (HP:0003298)1.68815697
144Pseudobulbar signs (HP:0002200)1.68296348
145Megalencephaly (HP:0001355)1.67916627
146Abnormal respiratory motile cilium morphology (HP:0005938)1.67449941
147Abnormal respiratory epithelium morphology (HP:0012253)1.67449941
148Abnormality of the intervertebral disk (HP:0005108)1.67315974
149Gait imbalance (HP:0002141)1.66870159
150Large earlobe (HP:0009748)1.65777249
151Synostosis involving bones of the hand (HP:0004278)1.65134636
152Abnormality of the duodenum (HP:0002246)1.64967360
153Abnormality of the preputium (HP:0100587)1.64535415
154Preaxial hand polydactyly (HP:0001177)1.64036319
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.63837766
156Coronal craniosynostosis (HP:0004440)1.60698786
157Patellar dislocation (HP:0002999)1.58180305
158Optic nerve hypoplasia (HP:0000609)1.58095520
159Renal hypoplasia (HP:0000089)1.57326505
160Anencephaly (HP:0002323)1.56699118
161Aplasia/Hypoplasia of the sternum (HP:0006714)1.54703584
162Gastrointestinal atresia (HP:0002589)1.54414863
163Rib fusion (HP:0000902)1.52464882
164Patellar aplasia (HP:0006443)1.50373527
165Holoprosencephaly (HP:0001360)1.49648388
166Obsessive-compulsive behavior (HP:0000722)1.49380763
167Oligodactyly (hands) (HP:0001180)1.49129753
168Abnormality of the incisor (HP:0000676)1.49127737
169Abnormality of the astrocytes (HP:0100707)1.48838368
170Astrocytoma (HP:0009592)1.48838368
171Tented upper lip vermilion (HP:0010804)1.48751904
172Aplasia/Hypoplasia of the patella (HP:0006498)1.48377171
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.47106368
174Hypoplasia of the fovea (HP:0007750)1.47106368
175Megalocornea (HP:0000485)1.46940028
176Pancreatic fibrosis (HP:0100732)1.46917936
177Down-sloping shoulders (HP:0200021)1.46884116
178Skull defect (HP:0001362)1.45550545
179Abnormality of the labia minora (HP:0012880)1.45396852
180Absent septum pellucidum (HP:0001331)1.45081162
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.44736932
182Zonular cataract (HP:0010920)1.44462926
183Abnormality of the septum pellucidum (HP:0007375)1.41590500
184Aplasia of the phalanges of the hand (HP:0009802)1.41438393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.35178092
2BUB14.34475260
3EPHB23.94713217
4STK163.45885281
5MAP3K102.98522531
6ICK2.83053076
7KSR12.72486550
8MARK12.41732182
9MKNK22.31436148
10SIK32.30472777
11MKNK12.19088046
12ERBB22.13380707
13CDK122.05400130
14BRD42.00158079
15ERBB31.96452756
16CDK191.94342762
17IRAK21.90010562
18NTRK21.87136226
19UHMK11.82981192
20WEE11.80890858
21SRPK11.80631062
22GRK11.77081626
23DDR21.72711820
24TYRO31.72386117
25ADRBK21.65495916
26CAMKK11.53180035
27MAPK151.48212395
28TLK11.47586263
29BMPR1B1.45807998
30MAP2K41.41471664
31ZAK1.36278448
32NME11.32513386
33VRK11.32424620
34PRKD31.30950212
35CSNK1A11.29010085
36MAP3K41.28237451
37LATS11.27111973
38BCR1.26297732
39DYRK1B1.25528829
40PAK61.24562229
41CASK1.24412834
42PLK41.21518973
43SIK21.20097159
44CAMK1G1.19722623
45MAPK131.15240413
46SYK1.14321205
47PNCK1.11079699
48CSNK1G21.07439479
49CDC71.07051652
50EPHA41.02702797
51AURKA1.02603635
52DYRK1A1.00522459
53BCKDK1.00335718
54SIK10.98708904
55INSRR0.98459113
56FGFR10.97626094
57MINK10.96773218
58ATM0.95375114
59DYRK20.93989772
60PINK10.92158144
61CSNK1G10.91581545
62EPHA30.91061397
63FGFR20.91029844
64PRKCG0.90833001
65NEK20.90187777
66PRKDC0.88746837
67DYRK30.88709690
68PRPF4B0.88382398
69PDGFRA0.84828081
70LATS20.83909566
71CDC42BPA0.83862523
72STK240.83574084
73SGK2230.81173888
74SGK4940.81173888
75TRIM280.80874802
76CCNB10.80329567
77BRSK20.79889703
78PAK40.77449377
79YES10.77214769
80NUAK10.76392435
81FRK0.70853659
82PRKCZ0.70794175
83MAP2K10.69891585
84CHEK10.69501729
85WNK40.68074747
86NEK10.67055527
87ATR0.66173309
88PLK30.65996341
89CDK70.65776700
90TRIB30.64739233
91WNK30.64456711
92PKN20.63606616
93MTOR0.63500369
94CDK10.63008739
95CAMK1D0.62438432
96CSNK1A1L0.61747393
97CSNK2A10.60642549
98AKT20.58768666
99CDK20.57866213
100LYN0.57728940
101RPS6KA20.57323248
102CDK180.57291096
103ROCK20.57132964
104TGFBR10.56097549
105HIPK20.56017641
106MAPK90.55695677
107GSK3B0.55622148
108CDK90.55586009
109SGK20.55444430
110TAF10.54815849
111RIPK10.54320493
112ROCK10.53136562
113TTK0.53076801
114PLK10.53073539
115MAP2K70.52620468
116CHEK20.52576184
117STK38L0.51552830
118AKT30.50959654
119TAOK20.50534260
120PLK20.50515138
121MAPK100.50401421
122CSNK1D0.49961896
123BRSK10.49626547
124MAPK140.48024179
125CSNK1E0.48014839
126PHKG10.47890154
127PHKG20.47890154
128VRK20.47049259
129CDK150.46612522
130MAP4K20.46060473
131CDK140.45829582
132CDK80.44694470
133ADRBK10.44563189
134TNIK0.43281085
135AURKB0.43234428
136PAK30.43012456
137STK110.43006333
138CDK11A0.42415829
139CSNK1G30.41744743
140CDK30.41599814
141NTRK30.40802106
142AKT10.40426159
143CAMK10.40327239
144ACVR1B0.39150526

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.11572227
2Collecting duct acid secretion_Homo sapiens_hsa049664.48372770
3Basal cell carcinoma_Homo sapiens_hsa052173.48584102
4Ribosome_Homo sapiens_hsa030103.28017489
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.06335017
6Notch signaling pathway_Homo sapiens_hsa043302.80991514
7Hedgehog signaling pathway_Homo sapiens_hsa043402.73083623
8Homologous recombination_Homo sapiens_hsa034402.59111205
9Hippo signaling pathway_Homo sapiens_hsa043902.31479679
10Axon guidance_Homo sapiens_hsa043602.20963632
11Oxidative phosphorylation_Homo sapiens_hsa001902.14215665
12Renin-angiotensin system_Homo sapiens_hsa046142.11022951
13One carbon pool by folate_Homo sapiens_hsa006702.03228511
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.00051725
15Spliceosome_Homo sapiens_hsa030401.99774419
16Parkinsons disease_Homo sapiens_hsa050121.93106307
17* mRNA surveillance pathway_Homo sapiens_hsa030151.91514751
18Wnt signaling pathway_Homo sapiens_hsa043101.89862611
19RNA polymerase_Homo sapiens_hsa030201.88784184
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87167911
21Olfactory transduction_Homo sapiens_hsa047401.73322095
22Sulfur relay system_Homo sapiens_hsa041221.72299579
23Huntingtons disease_Homo sapiens_hsa050161.66758227
24Cardiac muscle contraction_Homo sapiens_hsa042601.60661604
25Melanogenesis_Homo sapiens_hsa049161.55430195
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53202707
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.51405282
28Protein export_Homo sapiens_hsa030601.51100667
29Alzheimers disease_Homo sapiens_hsa050101.40742252
30Selenocompound metabolism_Homo sapiens_hsa004501.39957495
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39869647
32Endometrial cancer_Homo sapiens_hsa052131.39360305
33GABAergic synapse_Homo sapiens_hsa047271.39141003
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35854254
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35236240
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35063238
37Synaptic vesicle cycle_Homo sapiens_hsa047211.33837340
38Colorectal cancer_Homo sapiens_hsa052101.32651093
39Lysine degradation_Homo sapiens_hsa003101.32428382
40MicroRNAs in cancer_Homo sapiens_hsa052061.28620341
41Circadian entrainment_Homo sapiens_hsa047131.23992856
42Dorso-ventral axis formation_Homo sapiens_hsa043201.21502542
43Nicotine addiction_Homo sapiens_hsa050331.17015816
44Circadian rhythm_Homo sapiens_hsa047101.15566405
45Glutamatergic synapse_Homo sapiens_hsa047241.13066470
46Nucleotide excision repair_Homo sapiens_hsa034201.12844728
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12587031
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12115128
49Cell cycle_Homo sapiens_hsa041101.11355576
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10846118
51Dopaminergic synapse_Homo sapiens_hsa047281.08478381
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05810441
53Base excision repair_Homo sapiens_hsa034101.05476022
54RNA transport_Homo sapiens_hsa030131.02879478
55Oocyte meiosis_Homo sapiens_hsa041141.02731758
56Steroid biosynthesis_Homo sapiens_hsa001001.02306929
57mTOR signaling pathway_Homo sapiens_hsa041501.01631034
58Cholinergic synapse_Homo sapiens_hsa047251.00578318
59Morphine addiction_Homo sapiens_hsa050320.99258904
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.94701070
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94606467
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94483290
63Butanoate metabolism_Homo sapiens_hsa006500.93817939
64Gap junction_Homo sapiens_hsa045400.93767164
65Tight junction_Homo sapiens_hsa045300.92857463
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92830304
67TGF-beta signaling pathway_Homo sapiens_hsa043500.92776085
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92517727
69ErbB signaling pathway_Homo sapiens_hsa040120.91466363
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.90712990
71Folate biosynthesis_Homo sapiens_hsa007900.88496372
72Glioma_Homo sapiens_hsa052140.88116370
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86318045
74Pathways in cancer_Homo sapiens_hsa052000.85844190
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85050670
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84940949
77Alcoholism_Homo sapiens_hsa050340.84687125
78Bladder cancer_Homo sapiens_hsa052190.82973313
79Renal cell carcinoma_Homo sapiens_hsa052110.80412857
80Insulin secretion_Homo sapiens_hsa049110.80063968
81Chronic myeloid leukemia_Homo sapiens_hsa052200.79653692
82Adherens junction_Homo sapiens_hsa045200.79568139
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78597520
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78389185
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75945625
86Non-small cell lung cancer_Homo sapiens_hsa052230.75411304
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75035863
88HTLV-I infection_Homo sapiens_hsa051660.74778396
89Nitrogen metabolism_Homo sapiens_hsa009100.73221772
90Vitamin digestion and absorption_Homo sapiens_hsa049770.73011417
91Mismatch repair_Homo sapiens_hsa034300.72513169
92Systemic lupus erythematosus_Homo sapiens_hsa053220.72334125
93Cocaine addiction_Homo sapiens_hsa050300.72028379
94Serotonergic synapse_Homo sapiens_hsa047260.71945034
95Glycerolipid metabolism_Homo sapiens_hsa005610.71817107
96Linoleic acid metabolism_Homo sapiens_hsa005910.69336687
97Proteoglycans in cancer_Homo sapiens_hsa052050.69005432
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68685326
99Fanconi anemia pathway_Homo sapiens_hsa034600.66993946
100DNA replication_Homo sapiens_hsa030300.65799527
101Melanoma_Homo sapiens_hsa052180.65611440
102Basal transcription factors_Homo sapiens_hsa030220.64524849
103Oxytocin signaling pathway_Homo sapiens_hsa049210.62601229
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61110616
105RNA degradation_Homo sapiens_hsa030180.60629132
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60502038
107p53 signaling pathway_Homo sapiens_hsa041150.59557947
108cAMP signaling pathway_Homo sapiens_hsa040240.59532779
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58770986
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.58563585
111GnRH signaling pathway_Homo sapiens_hsa049120.57264411
112Gastric acid secretion_Homo sapiens_hsa049710.56040392
113Pyrimidine metabolism_Homo sapiens_hsa002400.56006290
114Prostate cancer_Homo sapiens_hsa052150.54716984
115Estrogen signaling pathway_Homo sapiens_hsa049150.54383544
116Pyruvate metabolism_Homo sapiens_hsa006200.52588006
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52078528
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51516129
119Long-term potentiation_Homo sapiens_hsa047200.50969337
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49636439
121Amphetamine addiction_Homo sapiens_hsa050310.48583754
122Fat digestion and absorption_Homo sapiens_hsa049750.47909447
123Tryptophan metabolism_Homo sapiens_hsa003800.47754800
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47325464
125Small cell lung cancer_Homo sapiens_hsa052220.47178600
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45524930
127MAPK signaling pathway_Homo sapiens_hsa040100.45480679
128Type II diabetes mellitus_Homo sapiens_hsa049300.44545784
129Purine metabolism_Homo sapiens_hsa002300.44424151
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44229162
131Propanoate metabolism_Homo sapiens_hsa006400.44138228
132AMPK signaling pathway_Homo sapiens_hsa041520.43507627
133Ether lipid metabolism_Homo sapiens_hsa005650.43444891
134Ras signaling pathway_Homo sapiens_hsa040140.43243116
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42880501
136Taste transduction_Homo sapiens_hsa047420.42765444
137Fatty acid biosynthesis_Homo sapiens_hsa000610.42437637
138Salivary secretion_Homo sapiens_hsa049700.41756049
139Long-term depression_Homo sapiens_hsa047300.41445811
140Choline metabolism in cancer_Homo sapiens_hsa052310.41142473
141Rap1 signaling pathway_Homo sapiens_hsa040150.38127958
142Insulin signaling pathway_Homo sapiens_hsa049100.37463934
143Metabolic pathways_Homo sapiens_hsa011000.37419447
144Glucagon signaling pathway_Homo sapiens_hsa049220.36989698
145Dilated cardiomyopathy_Homo sapiens_hsa054140.36294526
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35354715
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.34927304
148Pancreatic cancer_Homo sapiens_hsa052120.34856789
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34727637
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.34155785
151Chemical carcinogenesis_Homo sapiens_hsa052040.32204365
152Non-homologous end-joining_Homo sapiens_hsa034500.29646328
153beta-Alanine metabolism_Homo sapiens_hsa004100.29511638

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