MSANTD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.54351822
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.33633754
3presynaptic membrane assembly (GO:0097105)4.25951666
4synaptic vesicle maturation (GO:0016188)4.23767226
5regulation of synaptic vesicle exocytosis (GO:2000300)4.23324997
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14231646
7glutamate secretion (GO:0014047)4.08939236
8presynaptic membrane organization (GO:0097090)4.04972516
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90833747
10neurotransmitter secretion (GO:0007269)3.73397542
11regulation of synapse structural plasticity (GO:0051823)3.67391501
12tricarboxylic acid cycle (GO:0006099)3.65611385
13regulation of synaptic vesicle transport (GO:1902803)3.61724671
14vocalization behavior (GO:0071625)3.58743160
15nucleobase catabolic process (GO:0046113)3.56469493
16locomotory exploration behavior (GO:0035641)3.51879479
17proline transport (GO:0015824)3.50474554
18cell communication by electrical coupling (GO:0010644)3.49122076
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47191015
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43898410
21neuron cell-cell adhesion (GO:0007158)3.29163353
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.28323512
23retinal ganglion cell axon guidance (GO:0031290)3.26257415
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.24364582
25regulation of glutamate receptor signaling pathway (GO:1900449)3.24165288
26regulation of coenzyme metabolic process (GO:0051196)3.22177769
27regulation of cofactor metabolic process (GO:0051193)3.22177769
28regulation of acyl-CoA biosynthetic process (GO:0050812)3.20682955
29activation of protein kinase A activity (GO:0034199)3.19841402
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19157653
31succinate metabolic process (GO:0006105)3.19124814
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15098436
33nonmotile primary cilium assembly (GO:0035058)3.14479788
34layer formation in cerebral cortex (GO:0021819)3.12712831
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10684988
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07588738
37protein localization to synapse (GO:0035418)3.06364536
38establishment of nucleus localization (GO:0040023)3.03834870
39exploration behavior (GO:0035640)3.03650030
40Golgi transport vesicle coating (GO:0048200)2.98438457
41COPI coating of Golgi vesicle (GO:0048205)2.98438457
42postsynaptic membrane organization (GO:0001941)2.97859628
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95848418
44negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.94111337
45intraciliary transport (GO:0042073)2.93020563
46plasma membrane repair (GO:0001778)2.92546897
47axonal fasciculation (GO:0007413)2.90766505
48regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90538766
49regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.89380355
50oxaloacetate metabolic process (GO:0006107)2.88527063
51regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86217633
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86055827
53response to pheromone (GO:0019236)2.85298326
54DNA double-strand break processing (GO:0000729)2.84404018
55cerebellar Purkinje cell differentiation (GO:0021702)2.83532869
56neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.82129682
57regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.81997779
58neuron recognition (GO:0008038)2.76135710
59negative regulation of axon guidance (GO:1902668)2.75786262
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75244846
61vesicle transport along microtubule (GO:0047496)2.74749043
62dendritic spine morphogenesis (GO:0060997)2.73912603
63neuron fate determination (GO:0048664)2.73747057
64neurotransmitter transport (GO:0006836)2.73253347
65cell migration in hindbrain (GO:0021535)2.73206270
66gamma-aminobutyric acid transport (GO:0015812)2.70012675
67cell communication involved in cardiac conduction (GO:0086065)2.69274203
68membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68142164
69ganglion development (GO:0061548)2.68123069
70positive regulation of muscle hypertrophy (GO:0014742)2.65693064
71positive regulation of cardiac muscle hypertrophy (GO:0010613)2.65693064
72positive regulation of synapse assembly (GO:0051965)2.65631691
73cerebellar Purkinje cell layer development (GO:0021680)2.65569160
74negative regulation of microtubule polymerization (GO:0031115)2.65324914
75neuronal action potential propagation (GO:0019227)2.64261784
76negative regulation of membrane potential (GO:0045837)2.62551377
77regulation of sulfur metabolic process (GO:0042762)2.62331227
78innervation (GO:0060384)2.62204258
79neurotransmitter-gated ion channel clustering (GO:0072578)2.60447600
80pyrimidine nucleobase catabolic process (GO:0006208)2.59943547
81regulation of NFAT protein import into nucleus (GO:0051532)2.59579766
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.59368782
83negative regulation of glycogen biosynthetic process (GO:0045719)2.58394167
84neuromuscular process controlling posture (GO:0050884)2.57409348
85detection of calcium ion (GO:0005513)2.56719344
86neuron-neuron synaptic transmission (GO:0007270)2.55804342
87cardiac myofibril assembly (GO:0055003)2.55366448
88synaptic vesicle transport (GO:0048489)2.54828239
89establishment of synaptic vesicle localization (GO:0097480)2.54828239
90axon extension (GO:0048675)2.54139106
91ribonucleoprotein complex disassembly (GO:0032988)2.54079444
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53767537
93regulation of membrane repolarization (GO:0060306)2.53503132
94synaptic vesicle endocytosis (GO:0048488)2.53040941
95regulation of DNA endoreduplication (GO:0032875)2.51615463
96regulation of neurotransmitter levels (GO:0001505)2.50999420
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50745818
98regulation of synapse assembly (GO:0051963)2.50334693
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48979818
100regulation of neuronal synaptic plasticity (GO:0048168)2.47438779
101limb bud formation (GO:0060174)2.47057744
102organelle transport along microtubule (GO:0072384)2.46523653
103NADH metabolic process (GO:0006734)2.46476502
104establishment of integrated proviral latency (GO:0075713)2.46382439
105mitotic sister chromatid cohesion (GO:0007064)2.45931015
106mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45811364
107central nervous system projection neuron axonogenesis (GO:0021952)2.45181427
108peptidyl-arginine methylation (GO:0018216)2.44704797
109peptidyl-arginine N-methylation (GO:0035246)2.44704797
110cerebral cortex radially oriented cell migration (GO:0021799)2.44279226
111long-term synaptic potentiation (GO:0060291)2.43195406
112glutamate receptor signaling pathway (GO:0007215)2.42906790
113energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41146959
114ATP hydrolysis coupled proton transport (GO:0015991)2.41146959
115cullin deneddylation (GO:0010388)2.40853005
116nerve growth factor signaling pathway (GO:0038180)2.40025789
117negative regulation of DNA recombination (GO:0045910)2.39850300
118cerebellar granule cell differentiation (GO:0021707)2.39784464
119positive regulation of mitochondrial fission (GO:0090141)2.38460932
120negative regulation of neurotransmitter transport (GO:0051589)2.38298081
121establishment of vesicle localization (GO:0051650)2.38227192
122negative regulation of glycogen metabolic process (GO:0070874)2.38127964
123behavioral response to nicotine (GO:0035095)2.37256924
124thalamus development (GO:0021794)2.37006099
125regulation of synapse organization (GO:0050807)2.36249259
126synapse organization (GO:0050808)2.35630248
127regulation of cAMP-dependent protein kinase activity (GO:2000479)2.35497512
128cytoskeleton-dependent intracellular transport (GO:0030705)2.34591677
129dendrite morphogenesis (GO:0048813)2.34384181
130mechanosensory behavior (GO:0007638)2.34298651
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.34213548
132positive regulation of dendritic spine morphogenesis (GO:0061003)2.33790225
133olfactory bulb development (GO:0021772)2.33219810
134protein localization to cilium (GO:0061512)2.33057833
135organelle disassembly (GO:1903008)2.33014239
136histone H2A acetylation (GO:0043968)2.31193770
137microtubule-based transport (GO:0010970)2.26688492
138cilium morphogenesis (GO:0060271)2.25925472
139cardiac left ventricle morphogenesis (GO:0003214)2.25344119
140pancreas development (GO:0031016)2.25006251
141regulation of growth hormone secretion (GO:0060123)2.24583636
142positive regulation of gastrulation (GO:2000543)2.23994785
143establishment of melanosome localization (GO:0032401)2.22985955
144calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.22920797
145anterograde axon cargo transport (GO:0008089)2.21923341
146establishment of mitochondrion localization (GO:0051654)2.20904133
147lipid particle organization (GO:0034389)2.20279151
148regulation of glucokinase activity (GO:0033131)2.19777129
149regulation of hexokinase activity (GO:1903299)2.19777129
150melanosome transport (GO:0032402)2.19186813
151peptidyl-cysteine modification (GO:0018198)2.18870186
152monoubiquitinated protein deubiquitination (GO:0035520)2.18629470
153synaptic transmission, glutamatergic (GO:0035249)2.17082289
154cerebral cortex cell migration (GO:0021795)2.16829941
155regulation of axon guidance (GO:1902667)2.16637235
156insulin secretion (GO:0030073)2.15201374
157synapse assembly (GO:0007416)2.14894834
158hippocampus development (GO:0021766)2.14624359
159startle response (GO:0001964)2.14336677
160histone H2B ubiquitination (GO:0033523)2.14197955
161regulation of sarcomere organization (GO:0060297)2.13919510
162cilium assembly (GO:0042384)2.13637127
163axon extension involved in axon guidance (GO:0048846)2.12656586
164neuron projection extension involved in neuron projection guidance (GO:1902284)2.12656586
165auditory behavior (GO:0031223)2.11812764
166retina layer formation (GO:0010842)2.10975757
167regulation of feeding behavior (GO:0060259)2.10453973
168substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.10087433
169substrate-independent telencephalic tangential migration (GO:0021826)2.10087433
170axon cargo transport (GO:0008088)2.09034949
171positive regulation of RNA splicing (GO:0033120)2.08687344
172cilium organization (GO:0044782)2.08658138
173negative chemotaxis (GO:0050919)2.08203967
174otic vesicle formation (GO:0030916)2.07594501
175hindbrain development (GO:0030902)2.07093471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.50065539
2EZH2_22144423_ChIP-Seq_EOC_Human3.14211727
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87454818
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81211536
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66035253
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65462760
7ZNF274_21170338_ChIP-Seq_K562_Hela2.62094471
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35693513
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34217019
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26610103
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23883265
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23883265
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.23455381
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21497532
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17324149
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.17286912
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15750386
18IGF1R_20145208_ChIP-Seq_DFB_Human2.13732677
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12106933
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11310922
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02872563
22TAF15_26573619_Chip-Seq_HEK293_Human2.02281169
23SMAD4_21799915_ChIP-Seq_A2780_Human1.94651257
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.93950317
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92839281
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92759554
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89007975
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88599054
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88084705
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83256986
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81688272
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.77763262
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.76777299
34REST_21632747_ChIP-Seq_MESCs_Mouse1.76514798
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.74913082
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.74001199
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.72439322
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.71799657
39ELK1_19687146_ChIP-ChIP_HELA_Human1.71081817
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67604853
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.67168331
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67102697
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.66460910
44P300_19829295_ChIP-Seq_ESCs_Human1.64396377
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63372356
46VDR_22108803_ChIP-Seq_LS180_Human1.63303623
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.61827977
48FUS_26573619_Chip-Seq_HEK293_Human1.60447315
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59459442
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59433139
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55009555
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.54923004
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54813018
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53522539
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53263703
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51628153
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51370031
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50639055
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49198741
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45722548
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44736993
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44694890
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44593760
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44345504
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43648193
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43648193
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43636783
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43062026
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42078127
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41799655
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.41019354
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.40721854
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39686782
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39628940
75AR_25329375_ChIP-Seq_VCAP_Human1.39191213
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37310279
77AR_19668381_ChIP-Seq_PC3_Human1.34650890
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34256298
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34127722
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33604184
81DROSHA_22980978_ChIP-Seq_HELA_Human1.33500282
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.32839812
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32837950
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32539574
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30494607
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30263191
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30081669
88STAT3_23295773_ChIP-Seq_U87_Human1.29631077
89CLOCK_20551151_ChIP-Seq_293T_Human1.28690763
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26876299
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26415116
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26236177
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.26072340
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25407891
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24872895
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.24676259
97SOX9_26525672_Chip-Seq_HEART_Mouse1.24140215
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23340213
99AR_21572438_ChIP-Seq_LNCaP_Human1.22496111
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22429020
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.21386844
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.21082893
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19937729
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.19619514
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18370870
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16723855
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15737256
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15716207
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15413888
110P53_22387025_ChIP-Seq_ESCs_Mouse1.15085288
111ER_23166858_ChIP-Seq_MCF-7_Human1.13344294
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12887349
113JUN_21703547_ChIP-Seq_K562_Human1.12805486
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12489820
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12435462
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.11922882
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11594956
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11594956
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11318536
120E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10292035
121REST_19997604_ChIP-ChIP_NEURONS_Mouse1.10202739
122RNF2_27304074_Chip-Seq_NSC_Mouse1.09701109
123SOX2_16153702_ChIP-ChIP_HESCs_Human1.08944207
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.08925230
125BCAT_22108803_ChIP-Seq_LS180_Human1.08901771
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08430435
127CBP_20019798_ChIP-Seq_JUKART_Human1.08299563
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08299563
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06904503
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06897866
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06839147
132RUNX2_22187159_ChIP-Seq_PCA_Human1.06531410
133SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06289905
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06158983
135EWS_26573619_Chip-Seq_HEK293_Human1.05885958
136TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05725254
137ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05590366
138TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04463392
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.03564826
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.03308751
141RING1B_27294783_Chip-Seq_ESCs_Mouse1.02541748
142TCF4_23295773_ChIP-Seq_U87_Human1.02369992
143TP53_18474530_ChIP-ChIP_U2OS_Human1.01980858
144TP53_16413492_ChIP-PET_HCT116_Human0.99503042
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.98204083
146WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97580052

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.80849215
2MP0003122_maternal_imprinting3.20020551
3MP0002837_dystrophic_cardiac_calcinosis2.94412569
4MP0003635_abnormal_synaptic_transmissio2.68154873
5MP0009780_abnormal_chondrocyte_physiolo2.54181143
6MP0005248_abnormal_Harderian_gland2.49213491
7MP0003880_abnormal_central_pattern2.37190092
8MP0004084_abnormal_cardiac_muscle2.32200377
9MP0000751_myopathy2.25557712
10MP0002063_abnormal_learning/memory/cond2.22037637
11MP0002102_abnormal_ear_morphology2.12140523
12MP0006292_abnormal_olfactory_placode2.11494194
13MP0009046_muscle_twitch2.11140045
14MP0004270_analgesia2.09045438
15MP0004215_abnormal_myocardial_fiber2.08867691
16MP0000013_abnormal_adipose_tissue2.03729663
17MP0002909_abnormal_adrenal_gland2.00263838
18MP0009745_abnormal_behavioral_response1.98330371
19MP0001299_abnormal_eye_distance/1.91663420
20MP0006072_abnormal_retinal_apoptosis1.91003743
21MP0005423_abnormal_somatic_nervous1.87980790
22MP0004036_abnormal_muscle_relaxation1.87598218
23MP0002064_seizures1.82835212
24MP0002572_abnormal_emotion/affect_behav1.78036708
25MP0001968_abnormal_touch/_nociception1.75431231
26MP0005187_abnormal_penis_morphology1.72187761
27MP0003121_genomic_imprinting1.68466687
28MP0003123_paternal_imprinting1.63819001
29MP0002822_catalepsy1.62690615
30MP0005253_abnormal_eye_physiology1.57652395
31MP0002734_abnormal_mechanical_nocicepti1.57416578
32MP0002735_abnormal_chemical_nociception1.55909824
33MP0008058_abnormal_DNA_repair1.55888886
34MP0000778_abnormal_nervous_system1.54787312
35MP0005623_abnormal_meninges_morphology1.54454417
36MP0010386_abnormal_urinary_bladder1.53571160
37MP0006276_abnormal_autonomic_nervous1.53562449
38MP0008877_abnormal_DNA_methylation1.52228741
39MP0003787_abnormal_imprinting1.51336532
40MP0010234_abnormal_vibrissa_follicle1.49726678
41MP0004233_abnormal_muscle_weight1.45860474
42MP0003937_abnormal_limbs/digits/tail_de1.43215033
43MP0004811_abnormal_neuron_physiology1.41915089
44MP0008961_abnormal_basal_metabolism1.41040114
45MP0010368_abnormal_lymphatic_system1.40322948
46MP0002751_abnormal_autonomic_nervous1.38676349
47MP0001529_abnormal_vocalization1.37369211
48MP0008057_abnormal_DNA_replication1.36883595
49MP0002972_abnormal_cardiac_muscle1.36322235
50MP0005386_behavior/neurological_phenoty1.35974342
51MP0004924_abnormal_behavior1.35974342
52MP0003646_muscle_fatigue1.35715945
53MP0001188_hyperpigmentation1.33740929
54MP0002736_abnormal_nociception_after1.31694536
55MP0002733_abnormal_thermal_nociception1.30410026
56MP0002184_abnormal_innervation1.29598495
57MP0004085_abnormal_heartbeat1.28215283
58MP0005620_abnormal_muscle_contractility1.27812313
59MP0002272_abnormal_nervous_system1.25910791
60MP0002067_abnormal_sensory_capabilities1.25788162
61MP0002638_abnormal_pupillary_reflex1.25278359
62MP0003137_abnormal_impulse_conducting1.23956330
63MP0000537_abnormal_urethra_morphology1.22068296
64MP0005499_abnormal_olfactory_system1.20939067
65MP0005394_taste/olfaction_phenotype1.20939067
66MP0004145_abnormal_muscle_electrophysio1.20411314
67MP0004885_abnormal_endolymph1.18698258
68MP0002938_white_spotting1.17803906
69MP0004130_abnormal_muscle_cell1.17801571
70MP0001486_abnormal_startle_reflex1.17300266
71MP0002557_abnormal_social/conspecific_i1.16729757
72MP0000647_abnormal_sebaceous_gland1.15351089
73MP0005646_abnormal_pituitary_gland1.15153091
74MP0001440_abnormal_grooming_behavior1.13942206
75MP0000631_abnormal_neuroendocrine_gland1.13617509
76MP0000955_abnormal_spinal_cord1.13423846
77MP0003283_abnormal_digestive_organ1.13289288
78MP0008789_abnormal_olfactory_epithelium1.12305568
79MP0004484_altered_response_of1.11312794
80MP0000569_abnormal_digit_pigmentation1.08666850
81MP0008775_abnormal_heart_ventricle1.07809523
82MP0002233_abnormal_nose_morphology1.07579322
83MP0001293_anophthalmia1.06711125
84MP0004134_abnormal_chest_morphology1.06040916
85MP0000462_abnormal_digestive_system1.05484298
86MP0003861_abnormal_nervous_system1.05401072
87MP0004858_abnormal_nervous_system1.05017298
88MP0004087_abnormal_muscle_fiber1.04324721
89MP0001970_abnormal_pain_threshold1.02867323
90MP0002752_abnormal_somatic_nervous1.02322631
91MP0001286_abnormal_eye_development1.01937287
92MP0005330_cardiomyopathy1.00265962
93MP0000749_muscle_degeneration1.00107164
94MP0008438_abnormal_cutaneous_collagen0.99548436
95MP0003119_abnormal_digestive_system0.98696681
96MP0005391_vision/eye_phenotype0.97944894
97MP0003221_abnormal_cardiomyocyte_apopto0.97855071
98MP0002697_abnormal_eye_size0.97195601
99MP0006138_congestive_heart_failure0.97076256
100MP0010094_abnormal_chromosome_stability0.96904296
101MP0002090_abnormal_vision0.95958881
102MP0009250_abnormal_appendicular_skeleto0.95524091
103MP0005367_renal/urinary_system_phenotyp0.95380031
104MP0000516_abnormal_urinary_system0.95380031
105MP0003755_abnormal_palate_morphology0.95006876
106MP0002882_abnormal_neuron_morphology0.93734052
107MP0002896_abnormal_bone_mineralization0.93238391
108MP0004133_heterotaxia0.92918117
109MP0002066_abnormal_motor_capabilities/c0.92631986
110MP0002269_muscular_atrophy0.91471391
111MP0005551_abnormal_eye_electrophysiolog0.91201363
112MP0001501_abnormal_sleep_pattern0.90614018
113MP0003385_abnormal_body_wall0.90490121
114MP0004043_abnormal_pH_regulation0.90408163
115MP0002106_abnormal_muscle_physiology0.90167247
116MP0000049_abnormal_middle_ear0.89527366
117MP0000747_muscle_weakness0.88476674
118MP0004742_abnormal_vestibular_system0.88461400
119MP0008932_abnormal_embryonic_tissue0.88315785
120MP0008995_early_reproductive_senescence0.87788525
121MP0002653_abnormal_ependyma_morphology0.87628795
122MP0008007_abnormal_cellular_replicative0.87372790
123MP0000534_abnormal_ureter_morphology0.86776160
124MP0005257_abnormal_intraocular_pressure0.86209438
125MP0005503_abnormal_tendon_morphology0.85450205
126MP0005369_muscle_phenotype0.85135849
127MP0003890_abnormal_embryonic-extraembry0.84594390
128MP0003136_yellow_coat_color0.84362317
129MP0001177_atelectasis0.83716638
130MP0002095_abnormal_skin_pigmentation0.82733104
131MP0002152_abnormal_brain_morphology0.82654069
132MP0001984_abnormal_olfaction0.82102715
133MP0001544_abnormal_cardiovascular_syste0.81933980
134MP0005385_cardiovascular_system_phenoty0.81933980
135MP0002177_abnormal_outer_ear0.81838047
136MP0005195_abnormal_posterior_eye0.81236117
137MP0008569_lethality_at_weaning0.80834282
138MP0009384_cardiac_valve_regurgitation0.80318136
139MP0000759_abnormal_skeletal_muscle0.78903865
140MP0001270_distended_abdomen0.78863224
141MP0006054_spinal_hemorrhage0.78069128
142MP0002081_perinatal_lethality0.78008900
143MP0001348_abnormal_lacrimal_gland0.77489669
144MP0004272_abnormal_basement_membrane0.77255998
145MP0002234_abnormal_pharynx_morphology0.76109736
146MP0005171_absent_coat_pigmentation0.75229059
147MP0005645_abnormal_hypothalamus_physiol0.75151203
148MP0004142_abnormal_muscle_tone0.74740038

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)4.07669545
2Focal motor seizures (HP:0011153)3.72262739
3Pheochromocytoma (HP:0002666)3.55847769
4Neuroendocrine neoplasm (HP:0100634)3.46262729
5Visual hallucinations (HP:0002367)3.07811723
6Progressive cerebellar ataxia (HP:0002073)3.00406710
7Absence seizures (HP:0002121)2.99689253
8Medulloblastoma (HP:0002885)2.96278269
9Abnormality of the corticospinal tract (HP:0002492)2.93025489
10Focal seizures (HP:0007359)2.91867934
11Exercise-induced muscle cramps (HP:0003710)2.91837579
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.91772896
13Degeneration of the lateral corticospinal tracts (HP:0002314)2.91772896
14Febrile seizures (HP:0002373)2.90556208
15Epileptic encephalopathy (HP:0200134)2.75627760
16Gait imbalance (HP:0002141)2.74925449
17Neoplasm of the peripheral nervous system (HP:0100007)2.69732157
18Volvulus (HP:0002580)2.69569053
19Colon cancer (HP:0003003)2.62244380
20Congenital primary aphakia (HP:0007707)2.57073577
21Genital tract atresia (HP:0001827)2.56798815
22Agitation (HP:0000713)2.54840044
23Myokymia (HP:0002411)2.51732008
24Truncal ataxia (HP:0002078)2.48971679
25Nephrogenic diabetes insipidus (HP:0009806)2.48550655
26Intestinal atresia (HP:0011100)2.48224906
27Generalized tonic-clonic seizures (HP:0002069)2.47828396
28Papilledema (HP:0001085)2.46056303
29Hypoventilation (HP:0002791)2.44015154
30Impaired pain sensation (HP:0007328)2.42319829
31Abnormality of pain sensation (HP:0010832)2.42319829
32Dialeptic seizures (HP:0011146)2.39960576
33Medial flaring of the eyebrow (HP:0010747)2.39048235
34Resting tremor (HP:0002322)2.37789218
35Genetic anticipation (HP:0003743)2.35838282
36Shoulder girdle muscle weakness (HP:0003547)2.35452092
37Exercise-induced myalgia (HP:0003738)2.35239693
38True hermaphroditism (HP:0010459)2.34148939
39Cortical dysplasia (HP:0002539)2.34068718
40Neoplasm of the adrenal gland (HP:0100631)2.32991696
41Vaginal atresia (HP:0000148)2.31169906
42Pancreatic fibrosis (HP:0100732)2.30267280
43Hepatoblastoma (HP:0002884)2.30224432
44Oligodactyly (hands) (HP:0001180)2.27586878
45Papillary thyroid carcinoma (HP:0002895)2.25633247
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23632446
47Neoplasm of the oral cavity (HP:0100649)2.22340145
48Hyperventilation (HP:0002883)2.20459584
49Abnormality of the calf musculature (HP:0001430)2.20079594
50Renal cortical cysts (HP:0000803)2.16589197
51Long toe (HP:0010511)2.15352922
52Chronic hepatic failure (HP:0100626)2.11586769
53Hypercortisolism (HP:0001578)2.11438202
54Central scotoma (HP:0000603)2.11372656
55Atrial fibrillation (HP:0005110)2.11247409
56Impaired vibration sensation in the lower limbs (HP:0002166)2.10014280
57Depression (HP:0000716)2.09515443
58Gastrointestinal atresia (HP:0002589)2.07865219
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.06088976
60Abnormality of midbrain morphology (HP:0002418)2.06049623
61Molar tooth sign on MRI (HP:0002419)2.06049623
62Methylmalonic acidemia (HP:0002912)2.05418119
63Termporal pattern (HP:0011008)2.03908574
64Insidious onset (HP:0003587)2.03908574
65Astrocytoma (HP:0009592)2.03866891
66Abnormality of the astrocytes (HP:0100707)2.03866891
67Scanning speech (HP:0002168)2.02996519
68Fetal akinesia sequence (HP:0001989)2.02264777
69Primary atrial arrhythmia (HP:0001692)2.01718137
70Ketoacidosis (HP:0001993)2.01173542
71Nephronophthisis (HP:0000090)2.00747840
72Poor eye contact (HP:0000817)2.00232176
73Specific learning disability (HP:0001328)1.99354971
74Glioma (HP:0009733)1.98563317
75Urinary bladder sphincter dysfunction (HP:0002839)1.97768571
76Ankyloglossia (HP:0010296)1.97239519
77Sudden death (HP:0001699)1.95972204
78Hemiparesis (HP:0001269)1.95737363
79Epileptiform EEG discharges (HP:0011182)1.94980081
80Dysmetric saccades (HP:0000641)1.91536226
81Calf muscle hypertrophy (HP:0008981)1.89953495
82EEG with generalized epileptiform discharges (HP:0011198)1.89617212
83Pachygyria (HP:0001302)1.88570788
84Optic nerve hypoplasia (HP:0000609)1.88352962
85Limb dystonia (HP:0002451)1.88167595
86Supraventricular tachycardia (HP:0004755)1.86255242
87Anxiety (HP:0000739)1.86102548
88Supraventricular arrhythmia (HP:0005115)1.85579699
89Neoplasm of the thyroid gland (HP:0100031)1.85471872
90Hypsarrhythmia (HP:0002521)1.85339107
91Impaired social interactions (HP:0000735)1.85282921
92Abnormal social behavior (HP:0012433)1.85282921
93Poor coordination (HP:0002370)1.84364729
94Palpitations (HP:0001962)1.83770325
95Spastic tetraplegia (HP:0002510)1.83662191
96Prolonged QT interval (HP:0001657)1.82770733
97Broad foot (HP:0001769)1.82146332
98Ankle clonus (HP:0011448)1.81808537
99Abnormal hair whorl (HP:0010721)1.81792971
100Labial hypoplasia (HP:0000066)1.81650946
101Abnormality of the labia minora (HP:0012880)1.81627030
102Rimmed vacuoles (HP:0003805)1.81576821
103Narrow forehead (HP:0000341)1.81413744
104Myotonia (HP:0002486)1.81036060
105Muscular hypotonia of the trunk (HP:0008936)1.80779717
106Pancreatic cysts (HP:0001737)1.80679502
107Rhabdomyosarcoma (HP:0002859)1.80634138
108Abnormality of the metopic suture (HP:0005556)1.79156523
109Polyphagia (HP:0002591)1.79106408
110Failure to thrive in infancy (HP:0001531)1.77727593
111Meningioma (HP:0002858)1.77316462
112Hip dysplasia (HP:0001385)1.75918770
113Postaxial hand polydactyly (HP:0001162)1.75733483
114Paraplegia (HP:0010550)1.75637029
115Testicular neoplasm (HP:0010788)1.75453760
116Amblyopia (HP:0000646)1.75440896
117Conjunctival hamartoma (HP:0100780)1.74846052
118Hypoglycemic seizures (HP:0002173)1.74375853
119Drooling (HP:0002307)1.73749329
120Excessive salivation (HP:0003781)1.73749329
121Lissencephaly (HP:0001339)1.72726727
122Abnormality of the vocal cords (HP:0008777)1.72515324
123Progressive macrocephaly (HP:0004481)1.72458137
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.72440239
125Micropenis (HP:0000054)1.71745553
126Increased hepatocellular lipid droplets (HP:0006565)1.71079453
127Abnormality of the antihelix (HP:0009738)1.70744600
128Thyroid carcinoma (HP:0002890)1.70046139
129Abnormal mitochondria in muscle tissue (HP:0008316)1.69976911
130Ragged-red muscle fibers (HP:0003200)1.69820877
131Subacute progressive viral hepatitis (HP:0006572)1.68196775
132Postural tremor (HP:0002174)1.67916355
133Abnormality of the musculature of the pelvis (HP:0001469)1.66643309
134Abnormality of the hip-girdle musculature (HP:0001445)1.66643309
135Hypothermia (HP:0002045)1.66365016
136Short tibia (HP:0005736)1.66013929
137Hamartoma of the eye (HP:0010568)1.65962794
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.65933644
139Broad-based gait (HP:0002136)1.65769674
140Septo-optic dysplasia (HP:0100842)1.65139839
141Acute necrotizing encephalopathy (HP:0006965)1.65075519
142Hand muscle atrophy (HP:0009130)1.64357575
143Decreased testicular size (HP:0008734)1.64210772
144Postaxial foot polydactyly (HP:0001830)1.63924637
145Action tremor (HP:0002345)1.63566269
146Scrotal hypoplasia (HP:0000046)1.63390852
147Abnormality of the shoulder girdle musculature (HP:0001435)1.63263989
148Neoplasm of the adrenal cortex (HP:0100641)1.62452664
149Protrusio acetabuli (HP:0003179)1.62065366
150Poor suck (HP:0002033)1.61789537
151Pancreatic islet-cell hyperplasia (HP:0004510)1.61495600
152Urinary urgency (HP:0000012)1.61453076
153Generalized myoclonic seizures (HP:0002123)1.60924320
154Delayed gross motor development (HP:0002194)1.60909119
155Pelvic girdle muscle weakness (HP:0003749)1.60399662
156Increased serum pyruvate (HP:0003542)1.60232475
157Abnormality of glycolysis (HP:0004366)1.60232475
158Limb-girdle muscle atrophy (HP:0003797)1.59746587
159Pendular nystagmus (HP:0012043)1.59234276
160Abnormality of the lower motor neuron (HP:0002366)1.58727375
161Intellectual disability, profound (HP:0002187)1.58445547
162Lipid accumulation in hepatocytes (HP:0006561)1.57798587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.75645112
2MAP3K123.42780879
3PASK3.07205149
4KSR12.92371248
5MAP3K42.91163883
6MAP3K92.81985725
7TNIK2.66210834
8KSR22.59854653
9EIF2AK32.56096660
10CAMKK12.51574352
11ERBB32.50898811
12MINK12.38337612
13MKNK22.32652973
14MAP2K42.09628315
15MARK12.09109410
16MAP2K71.97291160
17MAP4K21.96774731
18TRIM281.90578289
19CASK1.87366905
20CSNK1G11.82428254
21PAK61.79087866
22MKNK11.78985599
23NEK11.76802888
24CAMKK21.73807002
25PAK31.73088017
26EPHA41.69654603
27PKN21.69388132
28PLK21.69336133
29SCYL21.69092496
30SRPK11.60029975
31TSSK61.55360462
32PDGFRA1.52892538
33ARAF1.49914836
34CSNK1A1L1.49853339
35CDC71.48948710
36FER1.44032109
37PDK41.42985042
38PDK31.42985042
39LATS21.42888512
40MAP3K21.29825361
41LMTK21.28326152
42RET1.27834778
43PHKG11.24467115
44PHKG21.24467115
45DYRK31.24390098
46TTN1.22912174
47WEE11.22377108
48NUAK11.15570446
49BRD41.14553608
50RAF11.09679696
51NTRK21.04424046
52TRIB31.02914807
53DYRK21.02494499
54ERBB41.02469308
55STK38L1.01832832
56CDK190.99768418
57AKT30.99484892
58MYLK0.97292653
59UHMK10.97208761
60EPHA30.96680578
61BUB10.94224262
62BCR0.92822505
63PINK10.91212196
64FGFR10.87734536
65FRK0.86397345
66MAP2K10.84664461
67DAPK10.84411140
68TGFBR10.83047089
69RPS6KA40.78752150
70PNCK0.78555551
71CDK50.78364489
72PRPF4B0.77505767
73PRKCG0.77354900
74CDK140.75246499
75ADRBK10.73366703
76EPHB20.73221526
77YES10.73151435
78FGFR20.72945468
79NTRK10.72651731
80PRKCE0.72244868
81SIK30.71560574
82DDR20.71464958
83PLK40.71215297
84ROCK10.70345376
85OBSCN0.70002137
86CAMK2A0.69511228
87STK390.68359521
88CDK180.68287386
89CSNK1G20.68069041
90NEK90.67785219
91DAPK20.64242479
92PLK10.63630510
93DYRK1A0.63611941
94VRK10.63078560
95LIMK10.62797491
96PAK40.62045760
97WNK30.61986086
98DYRK1B0.61902590
99INSRR0.61878921
100CSNK1E0.61775347
101ATM0.61347370
102BRAF0.60454028
103CDK30.59544388
104CDK150.58002993
105DMPK0.57915853
106CCNB10.57886907
107PRKD30.57188789
108SGK20.56940506
109MAP3K10.56628684
110MAP3K60.56050819
111STK160.53536373
112BMPR1B0.53267531
113MAP3K50.53225496
114ROCK20.53215168
115STK40.53010296
116CAMK1G0.52752402
117RPS6KA20.51935180
118CAMK2B0.51407848
119LATS10.50701797
120SGK2230.48938516
121SGK4940.48938516
122CSNK1G30.48905142
123CSNK1D0.48887682
124MAPK130.48626389
125STK30.48454035
126CSNK1A10.48326864
127PKN10.48218476
128BRSK20.47735808
129CDC42BPA0.46514350
130PTK20.46474905
131PRKDC0.44403964
132HIPK20.44224872
133GRK50.43334162
134CDK11A0.42083809
135PRKG10.42019787
136PBK0.41786300
137TTK0.41778676
138TYRO30.41475592
139PRKACB0.41178971
140SGK10.40883646
141WNK10.40607861
142PLK30.40459756
143GRK10.40254574
144EIF2AK10.38886218
145ACVR1B0.37398053
146CAMK2D0.36360278
147CDK80.36246469
148STK380.34703839
149SGK30.34645608
150ALK0.34643498

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.08547511
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.48477517
3Synaptic vesicle cycle_Homo sapiens_hsa047213.12100945
4Nicotine addiction_Homo sapiens_hsa050332.49270312
5GABAergic synapse_Homo sapiens_hsa047272.02576659
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00983856
7Long-term potentiation_Homo sapiens_hsa047201.96805544
8Basal transcription factors_Homo sapiens_hsa030221.91299298
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85713796
10Circadian entrainment_Homo sapiens_hsa047131.82476655
11Vibrio cholerae infection_Homo sapiens_hsa051101.77031861
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76927996
13Collecting duct acid secretion_Homo sapiens_hsa049661.76586429
14Dopaminergic synapse_Homo sapiens_hsa047281.75031875
15Insulin secretion_Homo sapiens_hsa049111.74125871
16Olfactory transduction_Homo sapiens_hsa047401.72397421
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71783131
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71443842
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70161133
20Non-homologous end-joining_Homo sapiens_hsa034501.66756507
21Steroid biosynthesis_Homo sapiens_hsa001001.65147579
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62738884
23Amphetamine addiction_Homo sapiens_hsa050311.48692787
24Dilated cardiomyopathy_Homo sapiens_hsa054141.47872754
25Morphine addiction_Homo sapiens_hsa050321.47463267
26Cholinergic synapse_Homo sapiens_hsa047251.46817741
27RNA degradation_Homo sapiens_hsa030181.42719430
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42037464
29Type II diabetes mellitus_Homo sapiens_hsa049301.39954816
30Gap junction_Homo sapiens_hsa045401.37156937
31Cardiac muscle contraction_Homo sapiens_hsa042601.31897712
32Folate biosynthesis_Homo sapiens_hsa007901.31236107
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30781121
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27827901
35Glutamatergic synapse_Homo sapiens_hsa047241.25722191
36Oxytocin signaling pathway_Homo sapiens_hsa049211.24987387
37Serotonergic synapse_Homo sapiens_hsa047261.23627047
38Long-term depression_Homo sapiens_hsa047301.22811350
39Cocaine addiction_Homo sapiens_hsa050301.22209300
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21192275
41Fatty acid elongation_Homo sapiens_hsa000621.19574951
42Hedgehog signaling pathway_Homo sapiens_hsa043401.19429855
43Glioma_Homo sapiens_hsa052141.17731264
44Nucleotide excision repair_Homo sapiens_hsa034201.14407264
45Taste transduction_Homo sapiens_hsa047421.13264409
46Selenocompound metabolism_Homo sapiens_hsa004501.12963880
47Fanconi anemia pathway_Homo sapiens_hsa034601.11938388
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11447105
49Basal cell carcinoma_Homo sapiens_hsa052171.11131097
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08329170
51GnRH signaling pathway_Homo sapiens_hsa049121.07711327
52RNA polymerase_Homo sapiens_hsa030201.07293683
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06185364
54mRNA surveillance pathway_Homo sapiens_hsa030151.05028595
55Renin secretion_Homo sapiens_hsa049241.04267141
56Gastric acid secretion_Homo sapiens_hsa049711.02637214
57ErbB signaling pathway_Homo sapiens_hsa040121.02518819
58RNA transport_Homo sapiens_hsa030131.01507582
59Huntingtons disease_Homo sapiens_hsa050161.01155258
60Salivary secretion_Homo sapiens_hsa049701.01151522
61Vitamin B6 metabolism_Homo sapiens_hsa007500.98993906
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98679894
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.97712194
64Glucagon signaling pathway_Homo sapiens_hsa049220.97323332
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96403881
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96225395
67Cell cycle_Homo sapiens_hsa041100.95998045
68Spliceosome_Homo sapiens_hsa030400.95646360
69mTOR signaling pathway_Homo sapiens_hsa041500.95548763
70Melanoma_Homo sapiens_hsa052180.95352112
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92991546
72Phototransduction_Homo sapiens_hsa047440.92563943
73Endometrial cancer_Homo sapiens_hsa052130.90988788
74Mismatch repair_Homo sapiens_hsa034300.89701106
75Butanoate metabolism_Homo sapiens_hsa006500.89696321
76Calcium signaling pathway_Homo sapiens_hsa040200.87978991
77Wnt signaling pathway_Homo sapiens_hsa043100.87649263
78Axon guidance_Homo sapiens_hsa043600.87599238
79Estrogen signaling pathway_Homo sapiens_hsa049150.86403440
80Melanogenesis_Homo sapiens_hsa049160.85763656
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85508805
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84961115
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84560129
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83582049
85Type I diabetes mellitus_Homo sapiens_hsa049400.82204822
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.81018141
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80676503
88Pyruvate metabolism_Homo sapiens_hsa006200.80523538
89Dorso-ventral axis formation_Homo sapiens_hsa043200.80173904
90Oocyte meiosis_Homo sapiens_hsa041140.80048949
91Insulin signaling pathway_Homo sapiens_hsa049100.79762989
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78559807
93cAMP signaling pathway_Homo sapiens_hsa040240.78558143
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76774676
95Focal adhesion_Homo sapiens_hsa045100.75976527
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.74320328
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73670286
98Colorectal cancer_Homo sapiens_hsa052100.73653311
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72965195
100p53 signaling pathway_Homo sapiens_hsa041150.72288591
101Renal cell carcinoma_Homo sapiens_hsa052110.70940176
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69736916
103Non-small cell lung cancer_Homo sapiens_hsa052230.69354168
104Carbon metabolism_Homo sapiens_hsa012000.68118362
105Phagosome_Homo sapiens_hsa041450.65625778
106Proteoglycans in cancer_Homo sapiens_hsa052050.65584810
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64678987
108Hippo signaling pathway_Homo sapiens_hsa043900.64369481
109Regulation of autophagy_Homo sapiens_hsa041400.63289295
110Alcoholism_Homo sapiens_hsa050340.62900343
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.61532999
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61521710
113Thyroid hormone synthesis_Homo sapiens_hsa049180.61267555
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60534488
115Fatty acid metabolism_Homo sapiens_hsa012120.60492870
116Parkinsons disease_Homo sapiens_hsa050120.60116624
117Proteasome_Homo sapiens_hsa030500.60028329
118beta-Alanine metabolism_Homo sapiens_hsa004100.59589504
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59042123
120TGF-beta signaling pathway_Homo sapiens_hsa043500.58603275
121Peroxisome_Homo sapiens_hsa041460.57778586
122Circadian rhythm_Homo sapiens_hsa047100.57673574
123Prolactin signaling pathway_Homo sapiens_hsa049170.57214747
124Homologous recombination_Homo sapiens_hsa034400.55768602
125Prion diseases_Homo sapiens_hsa050200.55682388
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55040810
127Ras signaling pathway_Homo sapiens_hsa040140.55012607
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52057935
129Oxidative phosphorylation_Homo sapiens_hsa001900.51566601
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51100719
131Insulin resistance_Homo sapiens_hsa049310.50914063
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50848640
133Rap1 signaling pathway_Homo sapiens_hsa040150.50375305
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49663174
135Tight junction_Homo sapiens_hsa045300.49581913
136MAPK signaling pathway_Homo sapiens_hsa040100.47696383
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47351973
138VEGF signaling pathway_Homo sapiens_hsa043700.47314168
139Bladder cancer_Homo sapiens_hsa052190.46884565
140Purine metabolism_Homo sapiens_hsa002300.46783704
141HIF-1 signaling pathway_Homo sapiens_hsa040660.45203249
142Adherens junction_Homo sapiens_hsa045200.43260983
143Alzheimers disease_Homo sapiens_hsa050100.43206035
144Propanoate metabolism_Homo sapiens_hsa006400.43044569
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41440924

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