MSANTD3-TMEFF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.45668755
2presynaptic membrane assembly (GO:0097105)5.14875060
3presynaptic membrane organization (GO:0097090)5.05693715
4nucleobase catabolic process (GO:0046113)4.98288642
5neuron recognition (GO:0008038)4.46664957
6axonal fasciculation (GO:0007413)4.42941055
7neuron cell-cell adhesion (GO:0007158)4.22236948
8postsynaptic membrane organization (GO:0001941)4.09251589
9cell migration in hindbrain (GO:0021535)4.05143413
10protein localization to synapse (GO:0035418)3.78174425
11establishment of mitochondrion localization (GO:0051654)3.75588671
12vocalization behavior (GO:0071625)3.67270865
13behavioral response to nicotine (GO:0035095)3.58703096
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56437946
15retinal ganglion cell axon guidance (GO:0031290)3.50741320
16central nervous system projection neuron axonogenesis (GO:0021952)3.46645283
17neurotransmitter-gated ion channel clustering (GO:0072578)3.43660922
18dendritic spine morphogenesis (GO:0060997)3.35013655
19dendrite morphogenesis (GO:0048813)3.27907066
20negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26453806
21transmission of nerve impulse (GO:0019226)3.25934847
22mitochondrion transport along microtubule (GO:0047497)3.24334679
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24334679
24auditory behavior (GO:0031223)3.22933398
25synapse assembly (GO:0007416)3.17931832
26neurofilament cytoskeleton organization (GO:0060052)3.16835522
27axon extension (GO:0048675)3.15947643
28substrate-independent telencephalic tangential migration (GO:0021826)3.15848305
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.15848305
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.13850963
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12583969
32cerebral cortex radially oriented cell migration (GO:0021799)3.10916904
33forebrain neuron differentiation (GO:0021879)3.07560436
34limb bud formation (GO:0060174)3.05211747
35regulation of synapse structural plasticity (GO:0051823)3.04841087
36positive regulation of synapse assembly (GO:0051965)3.03317607
37neuronal ion channel clustering (GO:0045161)3.03057384
38protein localization to cilium (GO:0061512)2.98705910
39mechanosensory behavior (GO:0007638)2.98614818
40olfactory bulb development (GO:0021772)2.95079804
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91218579
42ionotropic glutamate receptor signaling pathway (GO:0035235)2.90772802
43spinal cord development (GO:0021510)2.86924029
44neuron migration (GO:0001764)2.86463153
45synaptic vesicle maturation (GO:0016188)2.84174126
46synaptic transmission, glutamatergic (GO:0035249)2.79733212
47dendrite development (GO:0016358)2.79238103
48neuron projection extension involved in neuron projection guidance (GO:1902284)2.78882637
49axon extension involved in axon guidance (GO:0048846)2.78882637
50adult walking behavior (GO:0007628)2.78689637
51gamma-aminobutyric acid transport (GO:0015812)2.76849922
52nonmotile primary cilium assembly (GO:0035058)2.74765258
53layer formation in cerebral cortex (GO:0021819)2.68898099
54exploration behavior (GO:0035640)2.68361696
55positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64532420
56glutamate receptor signaling pathway (GO:0007215)2.64384186
57central nervous system neuron axonogenesis (GO:0021955)2.63766287
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62630837
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62319746
60ganglion development (GO:0061548)2.61136301
61neuron projection extension (GO:1990138)2.60433176
62short-term memory (GO:0007614)2.58846894
63negative regulation of axon guidance (GO:1902668)2.58018994
64hindbrain development (GO:0030902)2.56836844
65regulation of feeding behavior (GO:0060259)2.56196535
66response to auditory stimulus (GO:0010996)2.55370506
67sequestering of actin monomers (GO:0042989)2.54640064
68somite development (GO:0061053)2.54587928
69regulation of synaptic vesicle exocytosis (GO:2000300)2.54075257
70synapse organization (GO:0050808)2.53216526
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52306117
72neuromuscular synaptic transmission (GO:0007274)2.52162802
73neuron-neuron synaptic transmission (GO:0007270)2.51708196
74calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51377241
75neuronal action potential propagation (GO:0019227)2.51196084
76regulation of posttranscriptional gene silencing (GO:0060147)2.50145359
77regulation of gene silencing by miRNA (GO:0060964)2.50145359
78regulation of gene silencing by RNA (GO:0060966)2.50145359
79hippocampus development (GO:0021766)2.49894111
80regulation of synapse assembly (GO:0051963)2.49112879
81positive regulation of gastrulation (GO:2000543)2.48929460
82cerebral cortex cell migration (GO:0021795)2.48895272
83negative regulation of microtubule polymerization (GO:0031115)2.48194942
84atrial cardiac muscle cell action potential (GO:0086014)2.46619318
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43445826
86paraxial mesoderm development (GO:0048339)2.42770184
87innervation (GO:0060384)2.42485554
88intraciliary transport (GO:0042073)2.41651800
89negative regulation of translation, ncRNA-mediated (GO:0040033)2.41160781
90regulation of translation, ncRNA-mediated (GO:0045974)2.41160781
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41160781
92cochlea development (GO:0090102)2.40627200
93locomotory exploration behavior (GO:0035641)2.40570440
94axonogenesis (GO:0007409)2.39920619
95negative regulation of axonogenesis (GO:0050771)2.38728457
96neural tube formation (GO:0001841)2.37871882
97negative regulation of axon extension (GO:0030517)2.37309645
98establishment of nucleus localization (GO:0040023)2.37288597
99negative chemotaxis (GO:0050919)2.37124223
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37105889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89659922
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.62369300
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.33716390
4GBX2_23144817_ChIP-Seq_PC3_Human2.90266423
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79836221
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64097533
7TAF15_26573619_Chip-Seq_HEK293_Human2.50485740
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44079740
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.31111320
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.23301741
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23144581
12IGF1R_20145208_ChIP-Seq_DFB_Human2.22161825
13FUS_26573619_Chip-Seq_HEK293_Human2.15909137
14REST_21632747_ChIP-Seq_MESCs_Mouse2.14784045
15ZNF274_21170338_ChIP-Seq_K562_Hela2.14427359
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10173469
17RNF2_27304074_Chip-Seq_NSC_Mouse2.08727269
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06961481
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04656725
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98867976
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.98263523
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96566483
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96419937
24P300_19829295_ChIP-Seq_ESCs_Human1.94059911
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91867502
26VDR_22108803_ChIP-Seq_LS180_Human1.89913688
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88558538
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87563867
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.85085954
30EWS_26573619_Chip-Seq_HEK293_Human1.81291651
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79484640
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67888117
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.64109122
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61515829
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59955001
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59955001
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57621148
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57312510
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56811096
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56811096
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53338447
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52929244
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52575680
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52465536
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.51820289
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.51501903
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50603641
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48058024
49SMAD4_21799915_ChIP-Seq_A2780_Human1.46175551
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45520484
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43843818
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.42679694
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42637295
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.41817920
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.40424322
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39778434
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38263184
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38074744
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37632582
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.36595618
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34032435
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33838275
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30946627
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27142729
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26151251
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24900026
67IRF1_19129219_ChIP-ChIP_H3396_Human1.23411430
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.23233377
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21502105
70AR_25329375_ChIP-Seq_VCAP_Human1.20981870
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19588825
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.18365960
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18018852
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16982846
75AR_21572438_ChIP-Seq_LNCaP_Human1.14480152
76SOX9_26525672_Chip-Seq_HEART_Mouse1.13482860
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11480138
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10523838
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.09561370
80STAT3_23295773_ChIP-Seq_U87_Human1.09454603
81JUN_21703547_ChIP-Seq_K562_Human1.09175954
82RUNX2_22187159_ChIP-Seq_PCA_Human1.08149583
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.06013168
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05593560
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03310057
86TCF4_23295773_ChIP-Seq_U87_Human1.03011032
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02985529
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02882974
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02520282
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.02405747
91CBP_20019798_ChIP-Seq_JUKART_Human1.02252452
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02252452
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02184742
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01951001
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01924011
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.00761460
97MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99442141
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.98508947
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98493521
100RING1B_27294783_Chip-Seq_NPCs_Mouse0.97029313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.74369378
2MP0000778_abnormal_nervous_system2.97527687
3MP0004859_abnormal_synaptic_plasticity2.83458486
4MP0003122_maternal_imprinting2.69950941
5MP0002822_catalepsy2.68856875
6MP0004270_analgesia2.53734262
7MP0005423_abnormal_somatic_nervous2.51827752
8MP0003787_abnormal_imprinting2.50618934
9MP0003890_abnormal_embryonic-extraembry2.44998811
10MP0003121_genomic_imprinting2.43197197
11MP0001529_abnormal_vocalization2.36206438
12MP0006292_abnormal_olfactory_placode2.29717445
13MP0006276_abnormal_autonomic_nervous2.28111793
14MP0003635_abnormal_synaptic_transmissio2.09274583
15MP0001188_hyperpigmentation2.03457048
16MP0002734_abnormal_mechanical_nocicepti1.88806195
17MP0000569_abnormal_digit_pigmentation1.79835757
18MP0000955_abnormal_spinal_cord1.79468060
19MP0002063_abnormal_learning/memory/cond1.79281566
20MP0002272_abnormal_nervous_system1.77770757
21MP0002184_abnormal_innervation1.76937086
22MP0005499_abnormal_olfactory_system1.72584759
23MP0005394_taste/olfaction_phenotype1.72584759
24MP0004133_heterotaxia1.72066075
25MP0002735_abnormal_chemical_nociception1.70780698
26MP0009046_muscle_twitch1.67712928
27MP0009745_abnormal_behavioral_response1.67632525
28MP0008877_abnormal_DNA_methylation1.66473770
29MP0001984_abnormal_olfaction1.66404087
30MP0003123_paternal_imprinting1.65595548
31MP0002572_abnormal_emotion/affect_behav1.61942051
32MP0001486_abnormal_startle_reflex1.61100535
33MP0002102_abnormal_ear_morphology1.58902227
34MP0001293_anophthalmia1.58522993
35MP0008789_abnormal_olfactory_epithelium1.55121449
36MP0000566_synostosis1.54732988
37MP0003119_abnormal_digestive_system1.53484848
38MP0002064_seizures1.50962275
39MP0002736_abnormal_nociception_after1.48889353
40MP0002751_abnormal_autonomic_nervous1.48551761
41MP0002557_abnormal_social/conspecific_i1.48029447
42MP0001968_abnormal_touch/_nociception1.47292534
43MP0004811_abnormal_neuron_physiology1.45205364
44MP0002882_abnormal_neuron_morphology1.42639938
45MP0000631_abnormal_neuroendocrine_gland1.41017888
46MP0003861_abnormal_nervous_system1.40173471
47MP0005187_abnormal_penis_morphology1.39323933
48MP0004885_abnormal_endolymph1.35930858
49MP0004742_abnormal_vestibular_system1.35052452
50MP0002752_abnormal_somatic_nervous1.34910600
51MP0002938_white_spotting1.34904283
52MP0002067_abnormal_sensory_capabilities1.32214392
53MP0003136_yellow_coat_color1.31936736
54MP0002152_abnormal_brain_morphology1.31487839
55MP0003937_abnormal_limbs/digits/tail_de1.31269881
56MP0004142_abnormal_muscle_tone1.27431977
57MP0001970_abnormal_pain_threshold1.27299679
58MP0001299_abnormal_eye_distance/1.26900066
59MP0002233_abnormal_nose_morphology1.26367686
60MP0000049_abnormal_middle_ear1.24874000
61MP0003567_abnormal_fetal_cardiomyocyte1.22952642
62MP0002733_abnormal_thermal_nociception1.20635284
63MP0006072_abnormal_retinal_apoptosis1.20361132
64MP0002234_abnormal_pharynx_morphology1.20206547
65MP0002638_abnormal_pupillary_reflex1.19867773
66MP0002653_abnormal_ependyma_morphology1.18970109
67MP0005386_behavior/neurological_phenoty1.18163201
68MP0004924_abnormal_behavior1.18163201
69MP0001286_abnormal_eye_development1.17264409
70MP0003315_abnormal_perineum_morphology1.17097339
71MP0005551_abnormal_eye_electrophysiolog1.15344306
72MP0001485_abnormal_pinna_reflex1.13167589
73MP0003938_abnormal_ear_development1.11087090
74MP0010030_abnormal_orbit_morphology1.10013782
75MP0003283_abnormal_digestive_organ1.07669977
76MP0002697_abnormal_eye_size1.07389377
77MP0001440_abnormal_grooming_behavior1.06880503
78MP0008995_early_reproductive_senescence1.01689196
79MP0005195_abnormal_posterior_eye1.00219544
80MP0000026_abnormal_inner_ear0.99658604
81MP0005253_abnormal_eye_physiology0.98996112
82MP0003755_abnormal_palate_morphology0.94807381
83MP0002066_abnormal_motor_capabilities/c0.93199505
84MP0002081_perinatal_lethality0.89007190
85MP0003942_abnormal_urinary_system0.87173727
86MP0001905_abnormal_dopamine_level0.86325590
87MP0005645_abnormal_hypothalamus_physiol0.85966775
88MP0003385_abnormal_body_wall0.85164967
89MP0005391_vision/eye_phenotype0.84962868
90MP0000537_abnormal_urethra_morphology0.82572453
91MP0000647_abnormal_sebaceous_gland0.80072599
92MP0001963_abnormal_hearing_physiology0.78507292
93MP0000534_abnormal_ureter_morphology0.78465206
94MP0001177_atelectasis0.77302331
95MP0009379_abnormal_foot_pigmentation0.71967018
96MP0002069_abnormal_eating/drinking_beha0.71514602
97MP0002909_abnormal_adrenal_gland0.70958064
98MP0003935_abnormal_craniofacial_develop0.70520295
99MP0004145_abnormal_muscle_electrophysio0.69226828
100MP0005248_abnormal_Harderian_gland0.66112848

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)3.84261582
2Myokymia (HP:0002411)3.72919861
3Focal motor seizures (HP:0011153)3.16889051
4Cortical dysplasia (HP:0002539)3.15055944
5Abnormality of the labia minora (HP:0012880)3.06219019
6Drooling (HP:0002307)3.04549192
7Hepatoblastoma (HP:0002884)2.82865420
8Polyphagia (HP:0002591)2.81839259
9Focal seizures (HP:0007359)2.78967206
10Abnormality of the corticospinal tract (HP:0002492)2.77822987
11Septo-optic dysplasia (HP:0100842)2.74502991
12Excessive salivation (HP:0003781)2.74061362
13Gait imbalance (HP:0002141)2.62841257
14Lissencephaly (HP:0001339)2.61739380
15Optic nerve hypoplasia (HP:0000609)2.58513219
16Impaired vibration sensation in the lower limbs (HP:0002166)2.55034034
17Nephronophthisis (HP:0000090)2.52395232
18Abnormality of midbrain morphology (HP:0002418)2.47325968
19Molar tooth sign on MRI (HP:0002419)2.47325968
20Broad-based gait (HP:0002136)2.45916515
21Genital tract atresia (HP:0001827)2.39278855
22Vaginal atresia (HP:0000148)2.37144146
23Colon cancer (HP:0003003)2.35340755
24Intestinal atresia (HP:0011100)2.34902498
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33537606
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32512300
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.32512300
28Pancreatic fibrosis (HP:0100732)2.31212025
29Medial flaring of the eyebrow (HP:0010747)2.27961570
30Progressive cerebellar ataxia (HP:0002073)2.27645595
31Atonic seizures (HP:0010819)2.27564338
32Volvulus (HP:0002580)2.23067984
33Pachygyria (HP:0001302)2.22330228
34Epileptic encephalopathy (HP:0200134)2.21714135
35Agitation (HP:0000713)2.21638579
36Retinal dysplasia (HP:0007973)2.21400606
37Amyotrophic lateral sclerosis (HP:0007354)2.20618113
38Anophthalmia (HP:0000528)2.18554091
39Congenital primary aphakia (HP:0007707)2.17547431
40Febrile seizures (HP:0002373)2.17184611
41Hyperventilation (HP:0002883)2.13246337
42True hermaphroditism (HP:0010459)2.07635156
43Nephrogenic diabetes insipidus (HP:0009806)2.05540892
44Urinary urgency (HP:0000012)2.05394848
45Stenosis of the external auditory canal (HP:0000402)2.04228491
46Abnormality of the renal medulla (HP:0100957)2.03716945
47Specific learning disability (HP:0001328)2.03209734
48Dialeptic seizures (HP:0011146)2.01630899
49Bifid tongue (HP:0010297)2.00859169
50Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00529110
51Hypoplasia of the brainstem (HP:0002365)2.00529110
52Chronic hepatic failure (HP:0100626)1.98441005
53Absent septum pellucidum (HP:0001331)1.98069438
54Cutaneous finger syndactyly (HP:0010554)1.97026101
55Bilateral microphthalmos (HP:0007633)1.96354190
56Absent speech (HP:0001344)1.96192512
57Renal hypoplasia (HP:0000089)1.94485010
58Failure to thrive in infancy (HP:0001531)1.94211699
59Narrow forehead (HP:0000341)1.92898232
60Urinary bladder sphincter dysfunction (HP:0002839)1.92764349
61Generalized tonic-clonic seizures (HP:0002069)1.89895346
62Labial hypoplasia (HP:0000066)1.88888145
63Pancreatic cysts (HP:0001737)1.88732895
64Postaxial hand polydactyly (HP:0001162)1.88368616
65Micropenis (HP:0000054)1.87726481
66Pendular nystagmus (HP:0012043)1.86454864
67Abnormality of the lower motor neuron (HP:0002366)1.85897920
68Morphological abnormality of the pyramidal tract (HP:0002062)1.84651870
69Protruding tongue (HP:0010808)1.83830117
70Oligodactyly (hands) (HP:0001180)1.83257140
71Hyperglycinemia (HP:0002154)1.80887940
72Spastic tetraplegia (HP:0002510)1.77736353
73Growth hormone deficiency (HP:0000824)1.77234267
74Amblyopia (HP:0000646)1.77217161
75Hypoplastic female external genitalia (HP:0012815)1.76640707
76Inability to walk (HP:0002540)1.75641994
77Split foot (HP:0001839)1.75612324
78Exotropia (HP:0000577)1.74868510
79Cutaneous syndactyly (HP:0012725)1.74181703
80Poor suck (HP:0002033)1.73799580
81Sclerocornea (HP:0000647)1.73695669
82Scrotal hypoplasia (HP:0000046)1.73220784
83Abnormality of the septum pellucidum (HP:0007375)1.71990694
84Genetic anticipation (HP:0003743)1.71901218
85Anencephaly (HP:0002323)1.71030639
86Gastrointestinal atresia (HP:0002589)1.70577015
87Broad foot (HP:0001769)1.70116399
88Chorioretinal coloboma (HP:0000567)1.69318726
89Abnormal eating behavior (HP:0100738)1.68587486
90Poor coordination (HP:0002370)1.68460500
91Rib fusion (HP:0000902)1.67797787
92Absent eyebrow (HP:0002223)1.67562405
93Hypsarrhythmia (HP:0002521)1.66813265
94Myelomeningocele (HP:0002475)1.65612513
95Type II lissencephaly (HP:0007260)1.63838514
96Small hand (HP:0200055)1.63356968
97Absence seizures (HP:0002121)1.62516553
98Epileptiform EEG discharges (HP:0011182)1.62199816
99Esotropia (HP:0000565)1.60926005
100EEG with generalized epileptiform discharges (HP:0011198)1.60576624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.07410319
2CASK4.86350371
3MAP3K43.04927482
4TNIK3.04252900
5WNK32.88883784
6MAP2K72.62673491
7DYRK22.60673637
8BCR2.48232297
9PNCK2.34118551
10NTRK22.19213675
11MAPK132.12937023
12EPHA42.05967963
13NTRK31.91669292
14DYRK31.87194289
15MINK11.78478243
16TRIM281.58079552
17UHMK11.56965703
18CSNK1G21.54345868
19EPHB21.45164264
20TYRO31.31626501
21BMPR1B1.31091795
22MKNK21.30065589
23CDK191.28094641
24PRKCG1.25323773
25ERBB31.22720490
26MAP4K21.21206066
27MKNK11.19996386
28MAP2K41.19806196
29SIK21.18894535
30CDC71.13240295
31PINK11.10759309
32CSNK1G11.08089274
33CSNK1G31.07560610
34DYRK1A1.06173727
35MAP3K91.06115099
36PAK31.04533032
37SGK4941.03613602
38SGK2231.03613602
39EPHA31.02793174
40TAF10.98191037
41DYRK1B0.95379474
42PLK20.92499315
43CDK50.92015406
44CSNK1A1L0.90231038
45SGK20.87184752
46ADRBK20.87106111
47FGFR20.85506437
48ZAK0.84581714
49SRPK10.79655733
50PLK30.78335095
51NTRK10.76768884
52PLK40.75767154
53KSR10.74148826
54TSSK60.72292922
55LATS20.70866245
56CDK140.69394434
57CDK180.68576594
58CAMK2A0.66207158
59WEE10.66181231
60CDK150.64207378
61PRKCE0.64189122
62CAMK1G0.63280689
63WNK40.62064882
64CDK11A0.60686425
65CSNK1E0.58389819
66PHKG20.55533251
67PHKG10.55533251
68PKN10.54857974
69MAP3K60.54071063
70ACVR1B0.53984759
71GRK10.53754853
72DAPK20.52863274
73ERBB20.52424106
74FGFR10.51555901
75STK38L0.51293747
76RPS6KA40.51154656
77INSRR0.50867693
78VRK10.50414064
79NEK20.49254263
80PRKCZ0.46887832
81STK110.44451042
82CAMK2B0.42668085
83OXSR10.42638098
84CDK30.42488536
85PLK10.41113405
86PRKG10.41036648
87NUAK10.40333899
88CSNK1D0.38329197
89FRK0.38261124
90PRKACA0.38172674
91BRAF0.38081984
92TGFBR10.37718006
93PRKACB0.35321484
94CAMK40.35129237
95CHEK20.33980887
96PRKDC0.33040298
97MAPK150.32962970
98CSNK1A10.32136774
99SGK10.30295566
100BRD40.30147862

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.16831917
2GABAergic synapse_Homo sapiens_hsa047272.40774816
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33655342
4Morphine addiction_Homo sapiens_hsa050322.20664442
5Phototransduction_Homo sapiens_hsa047442.15953323
6Axon guidance_Homo sapiens_hsa043602.12025035
7Glutamatergic synapse_Homo sapiens_hsa047242.07641475
8Parkinsons disease_Homo sapiens_hsa050122.04406331
9Cocaine addiction_Homo sapiens_hsa050302.03259971
10Dopaminergic synapse_Homo sapiens_hsa047282.03063058
11Oxidative phosphorylation_Homo sapiens_hsa001902.03021025
12Cardiac muscle contraction_Homo sapiens_hsa042601.95287547
13Steroid biosynthesis_Homo sapiens_hsa001001.90952043
14Synaptic vesicle cycle_Homo sapiens_hsa047211.84665131
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82031309
16Circadian entrainment_Homo sapiens_hsa047131.81255455
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78982401
18Protein export_Homo sapiens_hsa030601.73160743
19Taste transduction_Homo sapiens_hsa047421.71043604
20Basal cell carcinoma_Homo sapiens_hsa052171.64049530
21Amphetamine addiction_Homo sapiens_hsa050311.55784648
22Hedgehog signaling pathway_Homo sapiens_hsa043401.53064138
23Basal transcription factors_Homo sapiens_hsa030221.50530890
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50476440
25Huntingtons disease_Homo sapiens_hsa050161.44033631
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40453690
27Serotonergic synapse_Homo sapiens_hsa047261.37989127
28Cholinergic synapse_Homo sapiens_hsa047251.37789583
29Alzheimers disease_Homo sapiens_hsa050101.36357161
30Hippo signaling pathway_Homo sapiens_hsa043901.32577055
31Insulin secretion_Homo sapiens_hsa049111.29034926
32Long-term depression_Homo sapiens_hsa047301.22560602
33Wnt signaling pathway_Homo sapiens_hsa043101.22232405
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21321475
35Olfactory transduction_Homo sapiens_hsa047401.21125777
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18435309
37Gap junction_Homo sapiens_hsa045401.17389452
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16014603
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12802854
40Alcoholism_Homo sapiens_hsa050341.10018948
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01738110
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98741111
43Melanogenesis_Homo sapiens_hsa049160.98504873
44Non-homologous end-joining_Homo sapiens_hsa034500.97056589
45Oocyte meiosis_Homo sapiens_hsa041140.94624726
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94594344
47Fanconi anemia pathway_Homo sapiens_hsa034600.85911029
48mRNA surveillance pathway_Homo sapiens_hsa030150.84252921
49Long-term potentiation_Homo sapiens_hsa047200.79587126
50RNA degradation_Homo sapiens_hsa030180.78692833
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78048336
52cAMP signaling pathway_Homo sapiens_hsa040240.76099262
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75954965
54Butanoate metabolism_Homo sapiens_hsa006500.74542271
55Ether lipid metabolism_Homo sapiens_hsa005650.73042125
56Ribosome_Homo sapiens_hsa030100.72466578
57Collecting duct acid secretion_Homo sapiens_hsa049660.72111002
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71597926
59Oxytocin signaling pathway_Homo sapiens_hsa049210.71003132
60Gastric acid secretion_Homo sapiens_hsa049710.69550105
61Colorectal cancer_Homo sapiens_hsa052100.69129201
62Linoleic acid metabolism_Homo sapiens_hsa005910.65005746
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63687576
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63516359
65RNA polymerase_Homo sapiens_hsa030200.63495118
66Ras signaling pathway_Homo sapiens_hsa040140.63316272
67Cell cycle_Homo sapiens_hsa041100.62511416
68RNA transport_Homo sapiens_hsa030130.62376036
69Tight junction_Homo sapiens_hsa045300.62013821
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61934942
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59573683
72Calcium signaling pathway_Homo sapiens_hsa040200.59500531
73Mismatch repair_Homo sapiens_hsa034300.58262376
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57704271
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57173536
76TGF-beta signaling pathway_Homo sapiens_hsa043500.53798942
77Spliceosome_Homo sapiens_hsa030400.53571956
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53447988
79Selenocompound metabolism_Homo sapiens_hsa004500.51756056
80Rap1 signaling pathway_Homo sapiens_hsa040150.51087631
81Salivary secretion_Homo sapiens_hsa049700.49271412
82Adherens junction_Homo sapiens_hsa045200.48671681
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47647721
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.47274964
85Propanoate metabolism_Homo sapiens_hsa006400.46844871
86ErbB signaling pathway_Homo sapiens_hsa040120.45780107
87Dilated cardiomyopathy_Homo sapiens_hsa054140.44209520
88Estrogen signaling pathway_Homo sapiens_hsa049150.43714024
89Type II diabetes mellitus_Homo sapiens_hsa049300.41819718
90Renin secretion_Homo sapiens_hsa049240.40757367
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38822728
92MAPK signaling pathway_Homo sapiens_hsa040100.38645789
93Nitrogen metabolism_Homo sapiens_hsa009100.38371726
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36691785
95Regulation of autophagy_Homo sapiens_hsa041400.35748506
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34506718
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33765907
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33507029
99Pyruvate metabolism_Homo sapiens_hsa006200.32304234
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31432665

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