MS4A6E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.81142405
2chromosome condensation (GO:0030261)8.37866107
3DNA packaging (GO:0006323)7.99793132
4plasma membrane fusion (GO:0045026)7.86562749
5single strand break repair (GO:0000012)7.81944718
6response to pheromone (GO:0019236)7.52489551
7spermatid development (GO:0007286)7.27845373
8spermatid nucleus differentiation (GO:0007289)7.24081912
9protein polyglutamylation (GO:0018095)7.23119053
10microtubule depolymerization (GO:0007019)6.95633627
11multicellular organism reproduction (GO:0032504)6.86326026
12sperm-egg recognition (GO:0035036)6.76288960
13sexual reproduction (GO:0019953)6.62993640
14reproduction (GO:0000003)6.55886069
15rRNA methylation (GO:0031167)6.29613460
16protein targeting to Golgi (GO:0000042)6.17525823
17negative regulation of inclusion body assembly (GO:0090084)6.10382567
18binding of sperm to zona pellucida (GO:0007339)6.02047945
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.02021393
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.00583499
21establishment of protein localization to Golgi (GO:0072600)5.94258639
22retrograde transport, vesicle recycling within Golgi (GO:0000301)5.87841511
23calcium ion-dependent exocytosis (GO:0017156)5.85919681
24microtubule polymerization or depolymerization (GO:0031109)5.77995434
25cell wall macromolecule catabolic process (GO:0016998)5.77088812
26axonemal dynein complex assembly (GO:0070286)5.72349887
27cell-cell recognition (GO:0009988)5.66792662
28spermatogenesis (GO:0007283)5.62924314
29male gamete generation (GO:0048232)5.60908409
30phosphatidylethanolamine metabolic process (GO:0046337)5.58181534
31rRNA modification (GO:0000154)5.50063332
32cell wall macromolecule metabolic process (GO:0044036)5.30162880
33regulation of Rab GTPase activity (GO:0032313)5.12456689
34positive regulation of Rab GTPase activity (GO:0032851)5.12456689
35gamete generation (GO:0007276)5.12335209
36microtubule severing (GO:0051013)5.12284979
37cellular ketone body metabolic process (GO:0046950)5.05040535
38motile cilium assembly (GO:0044458)4.91791970
39centriole replication (GO:0007099)4.86052926
40regulation of cilium movement (GO:0003352)4.78434202
41RNA destabilization (GO:0050779)4.72675750
42single fertilization (GO:0007338)4.61920399
43ketone body metabolic process (GO:1902224)4.42844960
44centriole assembly (GO:0098534)4.32414093
45protein localization to Golgi apparatus (GO:0034067)4.23891315
46cilium or flagellum-dependent cell motility (GO:0001539)4.22390562
47regulation of inclusion body assembly (GO:0090083)4.20159921
48multicellular organismal reproductive process (GO:0048609)4.13237359
49regulation of transcription involved in cell fate commitment (GO:0060850)4.11510270
50chromatin silencing (GO:0006342)4.10922043
51germ cell development (GO:0007281)3.98700256
52cellular process involved in reproduction in multicellular organism (GO:0022412)3.87803142
53regulation of T-helper 2 cell differentiation (GO:0045628)3.86343947
54fertilization (GO:0009566)3.73710064
55epithelial cilium movement (GO:0003351)3.67969155
56seminiferous tubule development (GO:0072520)3.64679604
57multicellular organismal movement (GO:0050879)3.42944774
58musculoskeletal movement (GO:0050881)3.42944774
59membrane protein intracellular domain proteolysis (GO:0031293)3.39867974
60nucleus organization (GO:0006997)3.39522919
61glycerol ether metabolic process (GO:0006662)3.33041700
62polyamine biosynthetic process (GO:0006596)3.26142742
63histone H3-K9 demethylation (GO:0033169)3.24567318
64glomerular visceral epithelial cell development (GO:0072015)3.20695932
65response to acidic pH (GO:0010447)3.18491122
66cilium movement (GO:0003341)3.15831991
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12893879
68negative regulation of Rho protein signal transduction (GO:0035024)3.11563398
69regulation of centriole replication (GO:0046599)3.08004750
70glomerular epithelial cell development (GO:0072310)3.07059985
71organic cation transport (GO:0015695)3.06018604
72positive regulation of type 2 immune response (GO:0002830)3.05477704
73ether metabolic process (GO:0018904)3.05212718
74peptide catabolic process (GO:0043171)3.04147434
75regulation of microtubule-based movement (GO:0060632)3.01289476
76coenzyme catabolic process (GO:0009109)2.88136239
77cerebral cortex neuron differentiation (GO:0021895)2.86699543
78NAD biosynthetic process (GO:0009435)2.85918301
79homeostasis of number of cells within a tissue (GO:0048873)2.84315513
80regulation of interleukin-13 production (GO:0032656)2.82717779
81multicellular organismal development (GO:0007275)2.81416986
82protein-DNA complex disassembly (GO:0032986)2.80245966
83nucleosome disassembly (GO:0006337)2.80245966
84cellular response to pH (GO:0071467)2.78779031
85negative regulation of gene expression, epigenetic (GO:0045814)2.78335618
86negative regulation of granulocyte differentiation (GO:0030853)2.71215609
87cell recognition (GO:0008037)2.67317435
88regulation of ARF GTPase activity (GO:0032312)2.63696238
89peptidyl-threonine dephosphorylation (GO:0035970)2.63400332
90cell differentiation involved in metanephros development (GO:0072202)2.63298691
91positive regulation of guanylate cyclase activity (GO:0031284)2.58438161
92microtubule nucleation (GO:0007020)2.57661419
93mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55172624
94mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55172624
95regulation of somitogenesis (GO:0014807)2.53463142
96alanine transport (GO:0032328)2.52865503
97outer ear morphogenesis (GO:0042473)2.52849031
98acrosome reaction (GO:0007340)11.1688452
99sperm motility (GO:0030317)11.0035621
100fusion of sperm to egg plasma membrane (GO:0007342)10.4607501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.58797334
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.42163785
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.30218298
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.86168057
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51475855
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42670526
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.42670526
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10943258
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01765499
10ELF1_20517297_ChIP-Seq_JURKAT_Human1.93191224
11* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88057847
12CBP_20019798_ChIP-Seq_JUKART_Human1.81288513
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.81288513
14BCL6_27268052_Chip-Seq_Bcells_Human1.77578769
15DROSHA_22980978_ChIP-Seq_HELA_Human1.72246842
16RAC3_21632823_ChIP-Seq_H3396_Human1.70410669
17EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.70347651
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69116751
19EZH2_22144423_ChIP-Seq_EOC_Human1.66931276
20VDR_24787735_ChIP-Seq_THP-1_Human1.65223689
21ERA_21632823_ChIP-Seq_H3396_Human1.65134024
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.63983679
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63490839
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58505068
25NANOG_20526341_ChIP-Seq_ESCs_Human1.57766232
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57124994
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.56934110
28BCOR_27268052_Chip-Seq_Bcells_Human1.56912559
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55627724
30MYC_19829295_ChIP-Seq_ESCs_Human1.51580818
31FUS_26573619_Chip-Seq_HEK293_Human1.51145956
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.48866326
33SMC4_20622854_ChIP-Seq_HELA_Human1.48737800
34RUNX_20019798_ChIP-Seq_JUKART_Human1.48292425
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.47729134
36E2F1_20622854_ChIP-Seq_HELA_Human1.47380928
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.45800403
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44309943
39TAF2_19829295_ChIP-Seq_ESCs_Human1.43596664
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43056593
41CTCF_20526341_ChIP-Seq_ESCs_Human1.42984560
42P68_20966046_ChIP-Seq_HELA_Human1.42001242
43P300_27268052_Chip-Seq_Bcells_Human1.40440810
44ER_23166858_ChIP-Seq_MCF-7_Human1.39686069
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.39614287
46* CTCF_27219007_Chip-Seq_Bcells_Human1.38403888
47TP63_22573176_ChIP-Seq_HFKS_Human1.38061989
48PHF8_20622854_ChIP-Seq_HELA_Human1.36848710
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.35949265
50LXR_22292898_ChIP-Seq_THP-1_Human1.35568899
51OCT4_20526341_ChIP-Seq_ESCs_Human1.33269262
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32397860
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32284444
54ERG_20517297_ChIP-Seq_VCAP_Human1.30025172
55SMRT_27268052_Chip-Seq_Bcells_Human1.26588320
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.25933153
57AR_25329375_ChIP-Seq_VCAP_Human1.25470946
58CEBPB_22108803_ChIP-Seq_LS180_Human1.25290367
59P300_19829295_ChIP-Seq_ESCs_Human1.25113747
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24482853
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24375449
62KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21429742
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20533938
64TAF15_26573619_Chip-Seq_HEK293_Human1.18921025
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.18456222
66GATA1_19941826_ChIP-Seq_K562_Human1.18274478
67RBPJ_21746931_ChIP-Seq_IB4_Human1.18193013
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.17767539
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17319629
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16931028
71HNFA_21074721_ChIP-Seq_CACO-2_Human1.16521816
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16452750
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14013902
74ETV1_20927104_ChIP-Seq_GIST48_Human1.12944152
75CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11083118
76SPI1_20517297_ChIP-Seq_HL60_Human1.10266010
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10212805
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09742728
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08428379
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06784289
81TP53_18474530_ChIP-ChIP_U2OS_Human1.05452123
82SA1_27219007_Chip-Seq_Bcells_Human1.05316500
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.05068710
84* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04778661
85SPI1_23127762_ChIP-Seq_K562_Human1.04242568
86OCT4_19829295_ChIP-Seq_ESCs_Human1.02997562
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02081460
88TBL1_22424771_ChIP-Seq_293T_Human1.01681006
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01644121
90RUNX2_22187159_ChIP-Seq_PCA_Human1.00547617
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.00191292
92PHF8_20622853_ChIP-Seq_HELA_Human1.00045919
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.00026529
94P53_21459846_ChIP-Seq_SAOS-2_Human0.99910681
95OCT1_27270436_Chip-Seq_PROSTATE_Human0.99730782
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99512592
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98708213
98STAT1_20625510_ChIP-Seq_HELA_Human0.98183695
99NFYB_21822215_ChIP-Seq_K562_Human0.96518560
100CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96260704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.16102250
2MP0003878_abnormal_ear_physiology4.50009106
3MP0005377_hearing/vestibular/ear_phenot4.50009106
4MP0003698_abnormal_male_reproductive3.70523368
5MP0001929_abnormal_gametogenesis3.18144272
6MP0001348_abnormal_lacrimal_gland2.79124850
7MP0003011_delayed_dark_adaptation2.11481223
8MP0005451_abnormal_body_composition2.03921419
9MP0002132_abnormal_respiratory_system2.03656233
10MP0002161_abnormal_fertility/fecundity2.00438990
11MP0005410_abnormal_fertilization10.9514626
12MP0005310_abnormal_salivary_gland1.97547309
13MP0004510_myositis1.73917027
14MP0003646_muscle_fatigue1.71940427
15MP0000569_abnormal_digit_pigmentation1.62125802
16MP0000678_abnormal_parathyroid_gland1.61202056
17MP0003172_abnormal_lysosome_physiology1.61176203
18MP0001485_abnormal_pinna_reflex1.56568388
19MP0002138_abnormal_hepatobiliary_system1.53392357
20MP0005248_abnormal_Harderian_gland1.52744453
21MP0000604_amyloidosis1.47762409
22MP0003329_amyloid_beta_deposits1.39636324
23MP0004742_abnormal_vestibular_system1.37860791
24MP0005379_endocrine/exocrine_gland_phen1.34213519
25MP0000566_synostosis1.33525237
26MP0003718_maternal_effect1.27347959
27MP0002735_abnormal_chemical_nociception1.24102169
28MP0003879_abnormal_hair_cell1.22277783
29MP0009115_abnormal_fat_cell1.19987818
30MP0002282_abnormal_trachea_morphology1.18928749
31MP0002210_abnormal_sex_determination1.17354297
32MP0001765_abnormal_ion_homeostasis1.16356237
33MP0003724_increased_susceptibility_to1.16103988
34MP0002419_abnormal_innate_immunity1.13402498
35MP0001963_abnormal_hearing_physiology1.13033697
36MP0000026_abnormal_inner_ear1.11859504
37MP0003828_pulmonary_edema1.11132374
38MP0005058_abnormal_lysosome_morphology1.10096810
39MP0001835_abnormal_antigen_presentation1.09130358
40MP0002229_neurodegeneration1.04980179
41MP0005666_abnormal_adipose_tissue1.03424805
42MP0005167_abnormal_blood-brain_barrier1.01177257
43MP0002249_abnormal_larynx_morphology1.00957084
44MP0001486_abnormal_startle_reflex0.99331056
45MP0006082_CNS_inflammation0.98837122
46MP0000681_abnormal_thyroid_gland0.98541939
47MP0003632_abnormal_nervous_system0.98208984
48MP0001145_abnormal_male_reproductive0.97639005
49MP0009764_decreased_sensitivity_to0.96034403
50MP0000653_abnormal_sex_gland0.95538273
51MP0001853_heart_inflammation0.94208939
52MP0002653_abnormal_ependyma_morphology0.92801476
53MP0002234_abnormal_pharynx_morphology0.90551175
54MP0005025_abnormal_response_to0.90496167
55MP0009785_altered_susceptibility_to0.90334090
56MP0001533_abnormal_skeleton_physiology0.88757186
57MP0003436_decreased_susceptibility_to0.87767382
58MP0008569_lethality_at_weaning0.87682801
59MP0005397_hematopoietic_system_phenotyp0.86901236
60MP0001545_abnormal_hematopoietic_system0.86901236
61MP0005671_abnormal_response_to0.84368931
62MP0003303_peritoneal_inflammation0.84085184
63MP0005375_adipose_tissue_phenotype0.83638943
64MP0005253_abnormal_eye_physiology0.82782942
65MP0000685_abnormal_immune_system0.75904689
66MP0005551_abnormal_eye_electrophysiolog0.73751896
67MP0009278_abnormal_bone_marrow0.73079165
68MP0005535_abnormal_body_temperature0.72959423
69MP0002723_abnormal_immune_serum0.72325799
70MP0009053_abnormal_anal_canal0.71800952
71MP0002452_abnormal_antigen_presenting0.71556057
72MP0002998_abnormal_bone_remodeling0.69570467
73MP0000015_abnormal_ear_pigmentation0.69462117
74MP0005595_abnormal_vascular_smooth0.68898817
75MP0004859_abnormal_synaptic_plasticity0.68877736
76MP0002971_abnormal_brown_adipose0.68858664
77MP0005000_abnormal_immune_tolerance0.66921571
78MP0002067_abnormal_sensory_capabilities0.66562649
79MP0005387_immune_system_phenotype0.64296121
80MP0001790_abnormal_immune_system0.64296121
81MP0002127_abnormal_cardiovascular_syste0.63432384
82MP0002148_abnormal_hypersensitivity_rea0.62845576
83MP0001440_abnormal_grooming_behavior0.62576527
84MP0008469_abnormal_protein_level0.61936882
85MP0000049_abnormal_middle_ear0.60299782
86MP0008961_abnormal_basal_metabolism0.59857578
87MP0003690_abnormal_glial_cell0.59554327
88MP0003631_nervous_system_phenotype0.58240575
89MP0005174_abnormal_tail_pigmentation0.57372857
90MP0000955_abnormal_spinal_cord0.57158473
91MP0005395_other_phenotype0.56696088
92MP0001800_abnormal_humoral_immune0.55644037
93MP0000249_abnormal_blood_vessel0.53877356
94MP0001968_abnormal_touch/_nociception0.53372798
95MP0001501_abnormal_sleep_pattern0.53348909
96MP0002733_abnormal_thermal_nociception0.52537796
97MP0002928_abnormal_bile_duct0.52355393
98MP0005423_abnormal_somatic_nervous0.52209133
99MP0003191_abnormal_cellular_cholesterol0.51979696
100MP0009840_abnormal_foam_cell0.51409559

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.60529681
2Asymmetric septal hypertrophy (HP:0001670)6.15348156
3Absent/shortened dynein arms (HP:0200106)5.30573896
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.30573896
5Attenuation of retinal blood vessels (HP:0007843)4.87915545
6Bony spicule pigmentary retinopathy (HP:0007737)4.59989074
7Cone-rod dystrophy (HP:0000548)4.28622046
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.17454132
9Nasal polyposis (HP:0100582)3.98916162
10Abnormal ciliary motility (HP:0012262)3.97224490
11Abnormal respiratory motile cilium physiology (HP:0012261)3.89180185
12Bell-shaped thorax (HP:0001591)3.88064103
13Abnormal respiratory motile cilium morphology (HP:0005938)3.82110685
14Abnormal respiratory epithelium morphology (HP:0012253)3.82110685
15Abnormality of macular pigmentation (HP:0008002)3.80647766
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.69742657
17Hypoplastic ischia (HP:0003175)3.67210344
18Resting tremor (HP:0002322)3.66637846
19Tubulointerstitial nephritis (HP:0001970)3.63797912
20Abnormal rod and cone electroretinograms (HP:0008323)3.54420418
21Male infertility (HP:0003251)3.48545883
22Enlarged epiphyses (HP:0010580)3.43068965
23Abnormality of the nasal mucosa (HP:0000433)3.40331207
24Infertility (HP:0000789)3.38694754
25Nephronophthisis (HP:0000090)3.31247075
26Vacuolated lymphocytes (HP:0001922)3.16275893
27Hyperkalemia (HP:0002153)3.13239159
28Abnormality of the ischium (HP:0003174)3.12621698
29Chronic hepatic failure (HP:0100626)3.10039058
30Facial shape deformation (HP:0011334)3.03022714
31Potter facies (HP:0002009)3.03022714
32Truncal obesity (HP:0001956)2.99601447
33Abnormal spermatogenesis (HP:0008669)2.99381139
34Generalized aminoaciduria (HP:0002909)2.98758839
35Postural instability (HP:0002172)2.95562983
36Hypoplasia of the thymus (HP:0000778)2.92313672
37Azoospermia (HP:0000027)2.87247770
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86519430
39Aplasia/Hypoplasia of the earlobes (HP:0009906)2.73838943
40Abnormality of macrophages (HP:0004311)2.73343332
41Amelogenesis imperfecta (HP:0000705)2.68651016
42Epiphyseal dysplasia (HP:0002656)2.66854506
43Increased cerebral lipofuscin (HP:0011813)2.61561520
44Abnormality of the renal medulla (HP:0100957)2.58779895
45Abnormality of glycolipid metabolism (HP:0010969)2.56500213
46Abnormality of liposaccharide metabolism (HP:0010968)2.56500213
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.56500213
48Impulsivity (HP:0100710)2.54936938
49Congenital sensorineural hearing impairment (HP:0008527)2.50370669
50Recurrent pneumonia (HP:0006532)2.50283918
51Stage 5 chronic kidney disease (HP:0003774)2.49561145
52Abnormal urine output (HP:0012590)2.49347544
53Hypoalphalipoproteinemia (HP:0003233)2.46945278
54Abnormality of dental color (HP:0011073)2.46646383
55Rhinitis (HP:0012384)2.36933680
56Polydipsia (HP:0001959)2.31996095
57Abnormal drinking behavior (HP:0030082)2.31996095
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.31270919
59Recurrent gram-negative bacterial infections (HP:0005420)2.29113011
60Protuberant abdomen (HP:0001538)2.25512527
61Progressive sensorineural hearing impairment (HP:0000408)2.24363104
62Portal hypertension (HP:0001409)2.22934834
63Renal Fanconi syndrome (HP:0001994)2.21794099
64Recurrent bacterial skin infections (HP:0005406)2.17413155
65Renal dysplasia (HP:0000110)2.14626604
66Abnormality of the costochondral junction (HP:0000919)2.14434701
67Abnormality of renal excretion (HP:0011036)2.09896459
68Tubulointerstitial abnormality (HP:0001969)2.04179419
69Gingivitis (HP:0000230)2.03981668
70Polyuria (HP:0000103)2.01569991
71Progressive cerebellar ataxia (HP:0002073)2.01224685
72Abnormality of the hepatic vasculature (HP:0006707)2.00451057
73Optic nerve hypoplasia (HP:0000609)1.96039438
74Decreased central vision (HP:0007663)1.93581357
75Failure to thrive in infancy (HP:0001531)1.92647383
76Recurrent abscess formation (HP:0002722)1.90099924
77Macular degeneration (HP:0000608)1.89704962
78Abnormal biliary tract physiology (HP:0012439)1.87127432
79Bile duct proliferation (HP:0001408)1.87127432
80Retinal atrophy (HP:0001105)1.86715725
81Insulin-resistant diabetes mellitus (HP:0000831)1.84278242
82Unilateral renal agenesis (HP:0000122)1.81710077
83Neoplasm of the heart (HP:0100544)1.80209422
84Abnormality of potassium homeostasis (HP:0011042)1.79971801
85Colitis (HP:0002583)1.78429261
86Chronic bronchitis (HP:0004469)1.77122429
87Tetany (HP:0001281)1.74623039
88Recurrent lower respiratory tract infections (HP:0002783)1.73697090
89Abnormality of the pubic bones (HP:0003172)1.73448167
90Esophageal atresia (HP:0002032)1.73391230
91Widely patent fontanelles and sutures (HP:0004492)1.69622189
92Bradykinesia (HP:0002067)1.69141845
93Bronchiectasis (HP:0002110)1.68813561
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68468504
95Short 4th metacarpal (HP:0010044)1.68468504
96Chronic obstructive pulmonary disease (HP:0006510)1.66506029
97Obstructive lung disease (HP:0006536)1.66506029
98Mixed hearing impairment (HP:0000410)1.66000324
99Supernumerary ribs (HP:0005815)1.65459611
100Abnormality of the aortic arch (HP:0012303)1.61975901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.30524947
2DDR25.21929863
3TESK14.72545873
4INSRR3.44126421
5MAP4K22.95414505
6STK382.94616531
7BRD42.85856665
8MAPK152.65947778
9PNCK2.60508776
10PLK22.41511804
11CAMK1G2.34386928
12STK38L2.10458673
13PIK3CG1.82186712
14PDPK11.71272083
15BLK1.70274621
16RIPK41.66038421
17PDK11.58910024
18PRKD31.55196523
19ADRBK21.41750656
20KSR21.38016042
21PTK2B1.37558063
22WNK11.35884808
23DYRK1B1.34876597
24MAP3K131.14738680
25MAP3K111.14328220
26GRK11.11313597
27TYRO31.00743969
28MAP3K10.99860381
29AKT30.91446213
30SIK20.89532120
31CAMK1D0.87396695
32MST1R0.85770393
33TESK20.83261259
34MAP3K20.81960726
35NEK60.80446354
36RPS6KA20.79751095
37CDK70.76574017
38FGFR20.73391645
39JAK30.72943731
40GRK70.72339968
41CDK120.72147623
42BMPR1B0.69934729
43BRAF0.68906114
44LATS10.68864123
45PRKG10.67532602
46CSK0.67165329
47RPS6KL10.66769903
48RPS6KC10.66769903
49ACVR1B0.66114029
50RPS6KA60.64894891
51TNIK0.62384773
52MAP3K80.60545158
53PRKAA20.59623451
54IKBKB0.59354901
55FGFR30.58889429
56TBK10.58101294
57RPS6KA10.58073308
58MAP3K30.58036091
59PRKG20.57805691
60IRAK40.57091046
61SYK0.55835581
62MAP2K20.53471905
63LATS20.53369736
64CAMK10.52968175
65NTRK30.52282669
66TAOK10.51572778
67MAP3K40.51420528
68CDK30.49527277
69MAP3K140.48586811
70ARAF0.44439814
71OXSR10.42754119
72SGK2230.41870148
73SGK4940.41870148
74MAP3K90.39836615
75KIT0.39198024
76PRKACB0.37655515
77MAP4K10.37338161
78IKBKE0.35189870
79TGFBR10.34932084
80FES0.34536458
81MAPK10.33056321
82SGK10.31173539
83TIE10.28752604
84JAK20.28611846
85GSK3B0.28292736
86PKN10.26818765
87ROCK10.26250216
88DYRK30.25776055
89SGK20.25182895
90UHMK10.23733651
91MAPK80.23505762
92MOS0.23393367
93LYN0.23338765
94MATK0.23017408
95CHUK0.22353093
96MAPK70.22268506
97CAMK40.22008219
98TXK0.21834130
99PRKCZ0.21716222
100CSF1R0.21380353

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.82990023
2Fatty acid biosynthesis_Homo sapiens_hsa000614.25744738
3Olfactory transduction_Homo sapiens_hsa047402.96209083
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.75156386
5Allograft rejection_Homo sapiens_hsa053302.73822489
6Autoimmune thyroid disease_Homo sapiens_hsa053202.53558962
7Graft-versus-host disease_Homo sapiens_hsa053322.51863912
8Antigen processing and presentation_Homo sapiens_hsa046122.45408647
9Type I diabetes mellitus_Homo sapiens_hsa049402.32523356
10Other glycan degradation_Homo sapiens_hsa005111.98797177
11Butanoate metabolism_Homo sapiens_hsa006501.86925422
12Glycerophospholipid metabolism_Homo sapiens_hsa005641.77723805
13Dorso-ventral axis formation_Homo sapiens_hsa043201.58771010
14Leishmaniasis_Homo sapiens_hsa051401.54618464
15Viral myocarditis_Homo sapiens_hsa054161.54078049
16Staphylococcus aureus infection_Homo sapiens_hsa051501.51413985
17Osteoclast differentiation_Homo sapiens_hsa043801.46100379
18Type II diabetes mellitus_Homo sapiens_hsa049301.44755490
19Taste transduction_Homo sapiens_hsa047421.36644756
20Lysosome_Homo sapiens_hsa041421.30405622
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.19861711
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.18588663
23Influenza A_Homo sapiens_hsa051641.17442657
24Phototransduction_Homo sapiens_hsa047441.15741602
25PPAR signaling pathway_Homo sapiens_hsa033201.09817347
26Tuberculosis_Homo sapiens_hsa051521.09482442
27Fatty acid degradation_Homo sapiens_hsa000711.07528838
28Legionellosis_Homo sapiens_hsa051341.06231174
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.04969041
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.03874955
31Glycerolipid metabolism_Homo sapiens_hsa005610.97538190
32B cell receptor signaling pathway_Homo sapiens_hsa046620.94146165
33Endocytosis_Homo sapiens_hsa041440.94033507
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93983019
35Asthma_Homo sapiens_hsa053100.93267359
36Phagosome_Homo sapiens_hsa041450.90727818
37Toxoplasmosis_Homo sapiens_hsa051450.88445185
38Chemokine signaling pathway_Homo sapiens_hsa040620.88015662
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87139669
40ABC transporters_Homo sapiens_hsa020100.83489331
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81781007
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80105265
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80059818
44Malaria_Homo sapiens_hsa051440.77344223
45Phenylalanine metabolism_Homo sapiens_hsa003600.76205797
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76004223
47Morphine addiction_Homo sapiens_hsa050320.72684728
48Hedgehog signaling pathway_Homo sapiens_hsa043400.71568487
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70072294
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69413871
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69090856
52Protein digestion and absorption_Homo sapiens_hsa049740.68608629
53Salivary secretion_Homo sapiens_hsa049700.67358560
54Rheumatoid arthritis_Homo sapiens_hsa053230.63275435
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62052434
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61920949
57Renin-angiotensin system_Homo sapiens_hsa046140.61377591
58MAPK signaling pathway_Homo sapiens_hsa040100.61097280
59cAMP signaling pathway_Homo sapiens_hsa040240.60872315
60Acute myeloid leukemia_Homo sapiens_hsa052210.59534711
61Estrogen signaling pathway_Homo sapiens_hsa049150.58240996
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58200637
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57604890
64VEGF signaling pathway_Homo sapiens_hsa043700.54893213
65Fatty acid metabolism_Homo sapiens_hsa012120.54374283
66Calcium signaling pathway_Homo sapiens_hsa040200.54261036
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53975382
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53361741
69Serotonergic synapse_Homo sapiens_hsa047260.52177275
70Nitrogen metabolism_Homo sapiens_hsa009100.51040906
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.50738743
72Platelet activation_Homo sapiens_hsa046110.49522000
73Herpes simplex infection_Homo sapiens_hsa051680.48100567
74Inositol phosphate metabolism_Homo sapiens_hsa005620.45198794
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.44770595
76Hematopoietic cell lineage_Homo sapiens_hsa046400.44517387
77Mineral absorption_Homo sapiens_hsa049780.43362730
78Renin secretion_Homo sapiens_hsa049240.42809540
79Linoleic acid metabolism_Homo sapiens_hsa005910.42624016
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41401417
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40811524
82Circadian entrainment_Homo sapiens_hsa047130.40722151
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38713034
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.38601242
85Arginine and proline metabolism_Homo sapiens_hsa003300.37568002
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36541177
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.35414233
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34699939
89Cardiac muscle contraction_Homo sapiens_hsa042600.32760348
90TNF signaling pathway_Homo sapiens_hsa046680.32107572
91Pancreatic secretion_Homo sapiens_hsa049720.31910953
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31737675
93Pertussis_Homo sapiens_hsa051330.30254298
94Retinol metabolism_Homo sapiens_hsa008300.30033101
95Bile secretion_Homo sapiens_hsa049760.29912270
96Gastric acid secretion_Homo sapiens_hsa049710.29278106
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29111958
98Glutamatergic synapse_Homo sapiens_hsa047240.27890404
99T cell receptor signaling pathway_Homo sapiens_hsa046600.27348299
100HIF-1 signaling pathway_Homo sapiens_hsa040660.27332964

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