MS4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.86816365
2cytidine catabolic process (GO:0006216)8.86816365
3cytidine deamination (GO:0009972)8.86816365
4regulation of B cell receptor signaling pathway (GO:0050855)8.67107446
5antigen processing and presentation of endogenous antigen (GO:0019883)7.92768568
6cellular response to zinc ion (GO:0071294)7.55109450
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.85606195
8positive regulation of gamma-delta T cell activation (GO:0046645)6.63975602
9regulation of B cell differentiation (GO:0045577)6.19339351
10somatic diversification of immune receptors via somatic mutation (GO:0002566)6.16002202
11somatic hypermutation of immunoglobulin genes (GO:0016446)6.16002202
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.44329663
13positive thymic T cell selection (GO:0045059)5.30080958
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.16774398
15positive regulation of B cell differentiation (GO:0045579)5.15331825
16regulation of B cell proliferation (GO:0030888)4.94955598
17negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.92222806
18regulation of gamma-delta T cell differentiation (GO:0045586)4.82506499
19negative regulation of B cell proliferation (GO:0030889)4.82134122
20regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.81322157
21mature B cell differentiation (GO:0002335)4.76130970
22* B cell proliferation (GO:0042100)4.70648124
23positive regulation by symbiont of host defense response (GO:0052509)4.62773532
24modulation by symbiont of host defense response (GO:0052031)4.62773532
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62773532
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62773532
27positive regulation by organism of defense response of other organism involved in symbiotic interact4.62773532
28modulation by symbiont of host immune response (GO:0052553)4.62773532
29positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.61683419
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57820466
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.57820466
32regulation of gamma-delta T cell activation (GO:0046643)4.56821954
33regulation of germinal center formation (GO:0002634)4.55082468
34regulation of B cell apoptotic process (GO:0002902)4.54458409
35negative regulation of cell killing (GO:0031342)4.48022591
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.48022591
37B cell homeostasis (GO:0001782)4.46532854
38regulation of antigen processing and presentation (GO:0002577)4.35993934
39antigen receptor-mediated signaling pathway (GO:0050851)4.29481092
40CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.24335967
41positive regulation of B cell proliferation (GO:0030890)4.23910919
42germinal center formation (GO:0002467)4.22827336
43cellular response to interleukin-15 (GO:0071350)4.19722139
44negative thymic T cell selection (GO:0045060)4.19032955
45detection of bacterium (GO:0016045)4.17875644
46regulation of interferon-beta biosynthetic process (GO:0045357)4.15735693
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.10811442
48negative regulation of B cell apoptotic process (GO:0002903)4.07343844
49immune response-activating cell surface receptor signaling pathway (GO:0002429)4.03982589
50macrophage activation involved in immune response (GO:0002281)4.03421828
51regulation of dendritic cell antigen processing and presentation (GO:0002604)4.00717576
52type I interferon signaling pathway (GO:0060337)3.96902589
53cellular response to type I interferon (GO:0071357)3.96902589
54response to type I interferon (GO:0034340)3.95550331
55* B cell activation (GO:0042113)3.93819006
56detection of other organism (GO:0098543)3.92282781
57response to interleukin-15 (GO:0070672)3.84434611
58negative T cell selection (GO:0043383)3.84017586
59complement activation, classical pathway (GO:0006958)3.80453489
60T cell migration (GO:0072678)3.78775247
61somatic diversification of immunoglobulins (GO:0016445)3.78223487
62positive T cell selection (GO:0043368)3.75035133
63interferon-gamma-mediated signaling pathway (GO:0060333)3.73672449
64negative regulation of gene silencing (GO:0060969)3.72675234
65immunoglobulin mediated immune response (GO:0016064)3.71019908
66lymphocyte homeostasis (GO:0002260)3.70748862
67thymic T cell selection (GO:0045061)3.70664357
68regulation of B cell activation (GO:0050864)3.68175683
69B cell activation involved in immune response (GO:0002312)3.67219654
70mature B cell differentiation involved in immune response (GO:0002313)3.66774598
71defense response to protozoan (GO:0042832)3.62650529
72immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.58791387
73Fc-gamma receptor signaling pathway (GO:0038094)3.58791387
74Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.58791387
75positive regulation of B cell activation (GO:0050871)3.58485486
76regulation of interferon-gamma biosynthetic process (GO:0045072)3.53266042
77Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.53237047
78regulation of alpha-beta T cell proliferation (GO:0046640)3.47061579
79T cell selection (GO:0045058)3.45409969
80regulation of histone H3-K27 methylation (GO:0061085)3.41197757
81lymph node development (GO:0048535)3.40765055
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40055497
83positive regulation of antigen processing and presentation (GO:0002579)3.37944523
84negative regulation of phagocytosis (GO:0050765)3.36169117
85positive regulation of Rap GTPase activity (GO:0032854)3.35342847
86negative regulation of histone methylation (GO:0031061)3.32083078
87NIK/NF-kappaB signaling (GO:0038061)3.31612184
88histamine secretion (GO:0001821)3.31435686
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30991730
90regulation of interleukin-12 biosynthetic process (GO:0045075)3.29482071
91respiratory burst (GO:0045730)3.28781693
92natural killer cell mediated immunity (GO:0002228)3.27542209
93natural killer cell mediated cytotoxicity (GO:0042267)3.27542209
94negative regulation of immunoglobulin mediated immune response (GO:0002890)3.27229321
95negative regulation of B cell mediated immunity (GO:0002713)3.27229321
96B cell differentiation (GO:0030183)3.26291164
97negative regulation of T cell receptor signaling pathway (GO:0050860)3.25338380
98response to host immune response (GO:0052572)3.25050242
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25050242
100somatic recombination of immunoglobulin gene segments (GO:0016447)3.24733567
101positive regulation of gene expression, epigenetic (GO:0045815)3.24271074
102negative regulation of humoral immune response (GO:0002921)3.23632809
103positive regulation of humoral immune response (GO:0002922)3.23312762
104positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23141510
105detection of external biotic stimulus (GO:0098581)3.20886451
106isotype switching (GO:0045190)3.20715229
107somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.20715229
108somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.20715229
109positive regulation of interferon-alpha production (GO:0032727)3.19421096
110T cell costimulation (GO:0031295)3.17766494
111leukocyte homeostasis (GO:0001776)3.17151248
112regulation of chromatin silencing (GO:0031935)3.14287107
113regulation of T cell receptor signaling pathway (GO:0050856)3.11761794
114cellular response to interferon-gamma (GO:0071346)3.11480374
115lymphocyte costimulation (GO:0031294)3.10199975
116positive regulation of immunoglobulin production (GO:0002639)3.10109786
117* lymphocyte proliferation (GO:0046651)3.08729875
118T cell lineage commitment (GO:0002360)3.08354768
119* mononuclear cell proliferation (GO:0032943)3.06853113
120cellular response to exogenous dsRNA (GO:0071360)3.06522378
121positive regulation of type 2 immune response (GO:0002830)3.04312125
122positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03962943
123regulation of interferon-alpha production (GO:0032647)3.02420563
124antigen processing and presentation via MHC class Ib (GO:0002475)3.02268867
125B cell mediated immunity (GO:0019724)3.01829325
126response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01742567
127response to host (GO:0075136)3.01742567
128response to host defenses (GO:0052200)3.01742567
129positive regulation of cell adhesion mediated by integrin (GO:0033630)3.01396074
130adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.01330073
131positive regulation of macrophage cytokine production (GO:0060907)3.00770619
132T-helper 1 type immune response (GO:0042088)2.99519627
133chaperone mediated protein folding requiring cofactor (GO:0051085)2.98356289
134positive regulation of interferon-beta production (GO:0032728)2.97984753
135positive regulation of interleukin-2 production (GO:0032743)2.97646160
136Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93992829
137response to protozoan (GO:0001562)2.93844011
138production of molecular mediator involved in inflammatory response (GO:0002532)2.93426964
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92783178
140regulation of T-helper 1 cell differentiation (GO:0045625)2.85686094
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.85362908
142negative regulation of alpha-beta T cell activation (GO:0046636)2.84756629
143regulation of interferon-beta production (GO:0032648)2.83797336
144adaptive immune response (GO:0002250)2.79904924
145B cell receptor signaling pathway (GO:0050853)10.3467630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.64675633
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.40878376
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.25996649
4E2F7_22180533_ChIP-Seq_HELA_Human5.05164120
5MYC_22102868_ChIP-Seq_BL_Human4.80587706
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.75105094
7IRF8_21731497_ChIP-ChIP_J774_Mouse4.45993212
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32098626
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15956129
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.12864444
11* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.08551057
12VDR_21846776_ChIP-Seq_THP-1_Human2.95547517
13RUNX_20019798_ChIP-Seq_JUKART_Human2.64794229
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56143170
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.47932531
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.45326629
17MYB_26560356_Chip-Seq_TH1_Human2.42840169
18MYB_26560356_Chip-Seq_TH2_Human2.42049398
19MAF_26560356_Chip-Seq_TH1_Human2.37663365
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.37610779
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23449208
22SPI1_23547873_ChIP-Seq_NB4_Human2.16569806
23CIITA_25753668_ChIP-Seq_RAJI_Human2.13426567
24UTX_26944678_Chip-Seq_JUKART_Human2.11600132
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11364852
26VDR_24763502_ChIP-Seq_THP-1_Human2.06217148
27* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05901095
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00704143
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99468669
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99237485
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93302965
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93235022
33SCL_19346495_ChIP-Seq_HPC-7_Human1.80603201
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.79418477
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79279756
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75594686
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74234092
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69447188
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69009935
40SPI1_23127762_ChIP-Seq_K562_Human1.65450656
41GATA1_22025678_ChIP-Seq_K562_Human1.61127056
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.59394906
43TCF7_22412390_ChIP-Seq_EML_Mouse1.56138981
44MAF_26560356_Chip-Seq_TH2_Human1.55469143
45GATA3_27048872_Chip-Seq_THYMUS_Human1.55296405
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49573529
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48855977
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47765526
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47636556
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46907483
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39156627
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38510632
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34887829
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33695591
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32067657
56* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30830207
57KDM2B_26808549_Chip-Seq_DND41_Human1.30711077
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29638540
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26568159
60FOXP3_21729870_ChIP-Seq_TREG_Human1.26400901
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26329343
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23260916
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21444049
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15687843
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13766293
66GATA3_26560356_Chip-Seq_TH2_Human1.07561628
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04786517
68PU_27001747_Chip-Seq_BMDM_Mouse1.03372666
69VDR_23849224_ChIP-Seq_CD4+_Human1.02588599
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02310158
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01688255
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99452610
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97876203
74ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96322075
75VDR_24787735_ChIP-Seq_THP-1_Human0.95673267
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94065848
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93940983
78KDM5A_27292631_Chip-Seq_BREAST_Human0.93529776
79SMRT_27268052_Chip-Seq_Bcells_Human0.92816056
80GATA3_26560356_Chip-Seq_TH1_Human0.92580185
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.91780231
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90506135
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90441651
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88838816
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88651059
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.88112249
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85531098
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84925090
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.84905499
90P300_27268052_Chip-Seq_Bcells_Human0.84523917
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84262894
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84030034
93BCOR_27268052_Chip-Seq_Bcells_Human0.83380540
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82485942
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80952916
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79127971
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.77599863
98BCL6_27268052_Chip-Seq_Bcells_Human0.75095930
99ELK1_19687146_ChIP-ChIP_HELA_Human0.74077237
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73777905
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73104806
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72923443
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72913895
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72530118
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72258127
106IRF1_19129219_ChIP-ChIP_H3396_Human0.71336855
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70984151
108CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70872341
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70199008
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69814274
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.68561208
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.68316740
113NCOR1_26117541_ChIP-Seq_K562_Human0.68286713
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67063418
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.65918658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.34661767
2MP0001800_abnormal_humoral_immune5.51064418
3MP0005387_immune_system_phenotype5.33169432
4MP0001790_abnormal_immune_system5.33169432
5MP0000685_abnormal_immune_system4.14679319
6* MP0002452_abnormal_antigen_presenting4.03612234
7MP0005000_abnormal_immune_tolerance3.52335021
8MP0005671_abnormal_response_to3.41579465
9MP0003303_peritoneal_inflammation3.40935013
10MP0002723_abnormal_immune_serum3.33794585
11* MP0002420_abnormal_adaptive_immunity3.22597094
12* MP0001819_abnormal_immune_cell3.09777615
13* MP0002398_abnormal_bone_marrow2.98558488
14MP0000689_abnormal_spleen_morphology2.77264822
15* MP0000716_abnormal_immune_system2.71954866
16MP0003763_abnormal_thymus_physiology2.40668861
17MP0002148_abnormal_hypersensitivity_rea2.23185441
18* MP0002429_abnormal_blood_cell2.21442764
19MP0002722_abnormal_immune_system2.17402827
20MP0005025_abnormal_response_to2.05487010
21MP0004510_myositis1.96653644
22MP0002419_abnormal_innate_immunity1.96043108
23MP0001348_abnormal_lacrimal_gland1.91411015
24MP0002166_altered_tumor_susceptibility1.89172369
25MP0008057_abnormal_DNA_replication1.86452112
26MP0003300_gastrointestinal_ulcer1.78811231
27MP0001873_stomach_inflammation1.76718661
28MP0009785_altered_susceptibility_to1.76709520
29MP0001853_heart_inflammation1.75042462
30MP0002405_respiratory_system_inflammati1.72567189
31MP0005310_abnormal_salivary_gland1.65920773
32MP0001845_abnormal_inflammatory_respons1.65695147
33MP0003183_abnormal_peptide_metabolism1.63901698
34MP0002396_abnormal_hematopoietic_system1.58739674
35MP0003724_increased_susceptibility_to1.57456084
36MP0010094_abnormal_chromosome_stability1.56032304
37MP0002933_joint_inflammation1.53829398
38MP0000703_abnormal_thymus_morphology1.40219459
39MP0003436_decreased_susceptibility_to1.35460322
40MP0010234_abnormal_vibrissa_follicle1.34967780
41MP0010155_abnormal_intestine_physiology1.31898122
42MP0004947_skin_inflammation1.31851088
43MP0002006_tumorigenesis1.31216015
44MP0004808_abnormal_hematopoietic_stem1.28679843
45MP0005645_abnormal_hypothalamus_physiol1.26202586
46MP0003077_abnormal_cell_cycle1.22313780
47MP0000569_abnormal_digit_pigmentation1.19004506
48MP0003787_abnormal_imprinting1.18080614
49MP0003866_abnormal_defecation1.12572605
50MP0002019_abnormal_tumor_incidence1.10878099
51MP0005464_abnormal_platelet_physiology1.10667304
52MP0002136_abnormal_kidney_physiology1.08557969
53MP0001879_abnormal_lymphatic_vessel1.03815535
54MP0009333_abnormal_splenocyte_physiolog1.01156384
55MP0010352_gastrointestinal_tract_polyps0.99846002
56MP0005075_abnormal_melanosome_morpholog0.99129563
57MP0000465_gastrointestinal_hemorrhage0.97542056
58MP0002163_abnormal_gland_morphology0.96908489
59MP0004381_abnormal_hair_follicle0.95994838
60MP0005174_abnormal_tail_pigmentation0.95817278
61MP0000371_diluted_coat_color0.86652009
62MP0002909_abnormal_adrenal_gland0.86296496
63MP0008469_abnormal_protein_level0.85547013
64MP0003091_abnormal_cell_migration0.83919487
65MP0002095_abnormal_skin_pigmentation0.82976654
66MP0000015_abnormal_ear_pigmentation0.81332765
67MP0003111_abnormal_nucleus_morphology0.81299623
68MP0006054_spinal_hemorrhage0.80741037
69MP0000858_altered_metastatic_potential0.79024267
70MP0003693_abnormal_embryo_hatching0.78551943
71MP0000013_abnormal_adipose_tissue0.77401528
72MP0005379_endocrine/exocrine_gland_phen0.73936897
73MP0002928_abnormal_bile_duct0.73733285
74MP0008260_abnormal_autophagy0.71293683
75MP0001533_abnormal_skeleton_physiology0.69951013
76MP0003045_fibrosis0.69629660
77MP0001986_abnormal_taste_sensitivity0.68430441
78MP0008874_decreased_physiological_sensi0.63195588
79MP0000350_abnormal_cell_proliferation0.63057246
80MP0003252_abnormal_bile_duct0.63024607
81MP0008877_abnormal_DNA_methylation0.61742385
82MP0009764_decreased_sensitivity_to0.61220172
83MP0008058_abnormal_DNA_repair0.59671518
84MP0002132_abnormal_respiratory_system0.59501664
85MP0005621_abnormal_cell_physiology0.56912678
86MP0004957_abnormal_blastocyst_morpholog0.56314948
87MP0000767_abnormal_smooth_muscle0.54831028
88MP0000372_irregular_coat_pigmentation0.54343237
89MP0001191_abnormal_skin_condition0.54162016
90MP0004883_abnormal_blood_vessel0.53505376
91MP0003221_abnormal_cardiomyocyte_apopto0.52704449
92MP0000313_abnormal_cell_death0.52425007
93MP0002139_abnormal_hepatobiliary_system0.51890196
94MP0005166_decreased_susceptibility_to0.50432973
95MP0002083_premature_death0.50360822
96MP0005397_hematopoietic_system_phenotyp0.50089457
97MP0001545_abnormal_hematopoietic_system0.50089457
98MP0000249_abnormal_blood_vessel0.49951016
99MP0009278_abnormal_bone_marrow0.49053929
100MP0000490_abnormal_crypts_of0.48948844
101MP0002138_abnormal_hepatobiliary_system0.48169313
102MP0002693_abnormal_pancreas_physiology0.46424206
103MP0000003_abnormal_adipose_tissue0.45960664
104MP0008961_abnormal_basal_metabolism0.45610147
105MP0005451_abnormal_body_composition0.45568521
106MP0001663_abnormal_digestive_system0.45392314
107MP0006082_CNS_inflammation0.45095334
108MP0003786_premature_aging0.44576777
109MP0000609_abnormal_liver_physiology0.44376544
110MP0005584_abnormal_enzyme/coenzyme_acti0.43536459
111MP0002168_other_aberrant_phenotype0.42742773
112MP0002877_abnormal_melanocyte_morpholog0.42602824
113MP0009115_abnormal_fat_cell0.41764488
114MP0003828_pulmonary_edema0.41333702
115MP0003566_abnormal_cell_adhesion0.40667316
116MP0002009_preneoplasia0.39907822
117MP0002135_abnormal_kidney_morphology0.39124440
118MP0001958_emphysema0.38517163
119MP0005384_cellular_phenotype0.36842458
120MP0001730_embryonic_growth_arrest0.36291241
121MP0009763_increased_sensitivity_to0.33074310
122MP0003172_abnormal_lysosome_physiology0.30816951
123MP0009643_abnormal_urine_homeostasis0.30666824

Predicted human phenotypes

RankGene SetZ-score
1* Gastrointestinal stroma tumor (HP:0100723)8.29374671
2Recurrent sinusitis (HP:0011108)7.68725414
3Recurrent bronchitis (HP:0002837)7.39477009
4Cellulitis (HP:0100658)6.49645658
5Colitis (HP:0002583)6.45414554
6IgA deficiency (HP:0002720)5.62223145
7Verrucae (HP:0200043)5.60858998
8Papilloma (HP:0012740)5.60858998
9IgM deficiency (HP:0002850)5.49125820
10Chronic sinusitis (HP:0011109)5.29976930
11Abnormal delayed hypersensitivity skin test (HP:0002963)5.22540956
12Inflammation of the large intestine (HP:0002037)5.22115046
13Recurrent lower respiratory tract infections (HP:0002783)5.12119099
14* Lymphopenia (HP:0001888)5.11167715
15Gastrointestinal inflammation (HP:0004386)4.98686398
16Recurrent pneumonia (HP:0006532)4.97093927
17* Abnormality of cells of the lymphoid lineage (HP:0012140)4.94744983
18Recurrent viral infections (HP:0004429)4.82026911
19Meningitis (HP:0001287)4.78553282
20* Emphysema (HP:0002097)4.73476340
21Panhypogammaglobulinemia (HP:0003139)4.56366142
22Bronchitis (HP:0012387)4.27163723
23Recurrent otitis media (HP:0000403)4.23477996
24Osteomyelitis (HP:0002754)4.07448574
25* Vasculitis (HP:0002633)4.06004469
26IgG deficiency (HP:0004315)4.01294326
27Small epiphyses (HP:0010585)3.83428201
28Chronic otitis media (HP:0000389)3.66653119
29* Restrictive lung disease (HP:0002091)3.62727079
30Recurrent cutaneous fungal infections (HP:0011370)3.58991947
31Chronic mucocutaneous candidiasis (HP:0002728)3.58991947
32Recurrent abscess formation (HP:0002722)3.52722716
33Recurrent bacterial skin infections (HP:0005406)3.41285769
34Sepsis (HP:0100806)3.32273329
35B lymphocytopenia (HP:0010976)3.28861726
36Abnormality of B cell number (HP:0010975)3.28861726
37Recurrent fungal infections (HP:0002841)3.26073223
38Viral hepatitis (HP:0006562)3.20803477
39Chronic diarrhea (HP:0002028)3.18101900
40Thyroiditis (HP:0100646)3.17631408
41Abnormality of T cell physiology (HP:0011840)3.14470248
42Mediastinal lymphadenopathy (HP:0100721)3.12642706
43Autoimmune thrombocytopenia (HP:0001973)3.07493002
44Mitral stenosis (HP:0001718)2.96229636
45Recurrent skin infections (HP:0001581)2.95059526
46* Leukopenia (HP:0001882)2.85725357
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.78001793
48Abnormality of T cells (HP:0002843)2.77863867
49Abnormality of macrophages (HP:0004311)2.73336695
50* Lymphoma (HP:0002665)2.71532865
51Vertebral arch anomaly (HP:0008438)2.71459096
52Abnormality of the prostate (HP:0008775)2.69046709
53Optic neuritis (HP:0100653)2.58326349
54Retrobulbar optic neuritis (HP:0100654)2.58326349
55Calf muscle hypertrophy (HP:0008981)2.53401542
56Skin rash (HP:0000988)2.52963901
57Abnormality of the fingertips (HP:0001211)2.52782899
58Encephalitis (HP:0002383)2.50040920
59Urticaria (HP:0001025)2.50026758
60Eczematoid dermatitis (HP:0000976)2.44155905
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42889643
62Increased IgM level (HP:0003496)2.38842338
63Gastrointestinal infarctions (HP:0005244)2.38485120
64Papilledema (HP:0001085)2.35348884
65Flattened epiphyses (HP:0003071)2.32027419
66Hypoplasia of the thymus (HP:0000778)2.31839368
67Neutropenia (HP:0001875)2.31479776
68Abnormality of T cell number (HP:0011839)2.30545252
69Chest pain (HP:0100749)2.29465457
70Orchitis (HP:0100796)2.24034644
71Myositis (HP:0100614)2.22440026
72Muscle hypertrophy of the lower extremities (HP:0008968)2.20504619
73Abnormality of the pleura (HP:0002103)2.20386172
74Skin ulcer (HP:0200042)2.19471072
75Absent epiphyses (HP:0010577)2.18822566
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.18822566
77Villous atrophy (HP:0011473)2.18064524
78Abnormality of small intestinal villus morphology (HP:0011472)2.18064524
79Autoimmune hemolytic anemia (HP:0001890)2.13520898
80Interstitial pulmonary disease (HP:0006530)2.11088837
81Irregular vertebral endplates (HP:0003301)2.10607674
82Xerostomia (HP:0000217)2.10394973
83T lymphocytopenia (HP:0005403)2.10274839
84Thrombocytosis (HP:0001894)2.10120607
85Chronic obstructive pulmonary disease (HP:0006510)2.07073318
86Obstructive lung disease (HP:0006536)2.07073318
87Keratoconjunctivitis sicca (HP:0001097)2.03626060
88Pulmonary infiltrates (HP:0002113)2.03264310
89Hemoptysis (HP:0002105)2.00606911
90Agammaglobulinemia (HP:0004432)10.7403693
91Poikiloderma (HP:0001029)1.95814893
92Increased IgE level (HP:0003212)1.94976534
93Ulnar bowing (HP:0003031)1.93392480
94Abnormality of the peritoneum (HP:0002585)1.93331729
95* Arthralgia (HP:0002829)1.92880620
96Hepatitis (HP:0012115)1.92752490
97Hypergammaglobulinemia (HP:0010702)1.92122654
98Severe combined immunodeficiency (HP:0004430)1.91763593
99Keratoconjunctivitis (HP:0001096)1.86084886
100Pustule (HP:0200039)1.85334502
101Recurrent gram-negative bacterial infections (HP:0005420)1.85152250
102Arthropathy (HP:0003040)1.83299593
103Aplasia/Hypoplasia of the thymus (HP:0010515)1.83005527
104Hypertensive crisis (HP:0100735)1.82543716
105Hematochezia (HP:0002573)1.82073072
106Abnormality of male internal genitalia (HP:0000022)1.80210723
107Elevated erythrocyte sedimentation rate (HP:0003565)1.73418780
108Abnormality of eosinophils (HP:0001879)1.71015887
109Teleangiectasia of the skin (HP:0100585)1.68024182
110Fatigue (HP:0012378)1.67155222
111Spontaneous hematomas (HP:0007420)1.66314861
112Nasal polyposis (HP:0100582)1.64862059
113Basal cell carcinoma (HP:0002671)1.62956847
114Dehydration (HP:0001944)1.58135458
115Abnormality of the vertebral endplates (HP:0005106)1.57594411
116Eosinophilia (HP:0001880)1.56794350
117Hypochromic anemia (HP:0001931)1.55673737
118Acrocyanosis (HP:0001063)1.54326046
119Barrel-shaped chest (HP:0001552)1.54293427
120Combined immunodeficiency (HP:0005387)1.51478697
121Limb hypertonia (HP:0002509)1.51042021
122Mucosal telangiectasiae (HP:0100579)1.50958494
123Aortic regurgitation (HP:0001659)1.49796125
124Periodontitis (HP:0000704)1.47733165
125Bronchiectasis (HP:0002110)1.46157845
126Gingivitis (HP:0000230)1.44418113
127Granulocytopenia (HP:0001913)1.43551665
128Abnormality of the intervertebral disk (HP:0005108)1.40519879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.35948713
2BLK3.70984458
3CDK193.68687624
4SYK3.27293317
5CSF1R3.27008162
6GRK63.21356513
7ERN12.98491080
8BTK2.90001061
9RIPK42.75462634
10MAP3K132.54839542
11PRPF4B2.47921090
12LRRK22.38572144
13STK102.27423331
14MAP3K102.22218738
15MAP3K142.19686897
16LYN2.16639850
17GRK11.94307185
18KIT1.91740423
19MST41.80658012
20PRKCH1.71194008
21TYK21.71148312
22PRKCQ1.66501373
23JAK11.64135776
24SIK21.57682060
25IRAK31.55801742
26CSK1.54181681
27HCK1.44457554
28TEC1.35515216
29EIF2AK31.27039931
30CLK11.25879856
31ITK1.24749703
32PASK1.21445081
33IKBKB1.19089818
34SMG11.18858964
35MARK31.18555070
36TBK11.17488626
37IRAK41.16979995
38SIK31.15733587
39LCK1.15405089
40CDK121.15398677
41PRKCI1.13951345
42MAPK111.12447166
43MATK1.11313153
44CDC42BPA1.08845185
45ARAF1.08175642
46JAK31.03230423
47FRK1.00092806
48FES0.97657882
49ZAP700.86864472
50CCNB10.86720499
51TAOK30.84925928
52BRD40.84782534
53NEK20.77928281
54FGFR30.77153716
55TNK20.73826010
56TGFBR20.71694138
57MAPK70.68445904
58CSNK1A1L0.68328141
59KSR20.67351462
60IKBKE0.66450664
61ALK0.65338821
62PIM10.64456871
63PIK3CG0.63848357
64RPS6KA40.63780572
65ABL10.62055601
66FYN0.61546119
67TLK10.60775260
68INSR0.58894263
69EIF2AK10.58272863
70TESK20.58042299
71CHUK0.58004307
72JAK20.55735454
73MELK0.55471938
74MAP2K30.53033071
75PRKCD0.52449556
76MARK20.51983819
77MAP3K90.50224058
78CSNK1G30.50144993
79MAPK120.49469780
80SIK10.49352219
81STK40.48635395
82CDK40.48029649
83DYRK1B0.47536026
84CSNK1G10.47392338
85CDC70.47001241
86HIPK20.46572360
87FGR0.46515759
88PDPK10.46374749
89MAP3K10.44852370
90PDK10.44824147
91BMPR20.44493916
92TRIB30.44081201
93IRAK20.40288049
94FGFR40.39779242
95RAF10.39217435
96MAP2K10.37870611
97STK240.37723915
98TXK0.37683506
99CDK90.37532969
100RPS6KB10.36630604
101PRKD10.36236960
102PRKD20.35574948
103ATR0.34973737
104BRAF0.34310537
105IRAK10.33786476
106EEF2K0.32850265
107MAP3K80.32754871
108MAPK40.32501028
109DYRK30.31900756
110SCYL20.31802658
111MAPKAPK20.31624520
112CSNK1D0.30899914
113MAP3K70.30455610
114CSNK1G20.29312133
115EGFR0.28190888
116SGK30.27959967
117CHEK10.26594218
118NLK0.24831809
119NEK90.23940567
120ACVR1B0.23454371
121PRKCZ0.23225068
122MAP2K20.21066777
123PKN10.20635321
124FGFR20.20560133
125DYRK1A0.20299902
126BUB10.18454612
127CAMK1G0.17064834
128WNK10.16649904

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.43686260
2B cell receptor signaling pathway_Homo sapiens_hsa046626.69975200
3Asthma_Homo sapiens_hsa053104.25912577
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.53022726
5NF-kappa B signaling pathway_Homo sapiens_hsa040643.03366740
6* Hematopoietic cell lineage_Homo sapiens_hsa046402.57361972
7Antigen processing and presentation_Homo sapiens_hsa046122.52269914
8Staphylococcus aureus infection_Homo sapiens_hsa051502.49366470
9Base excision repair_Homo sapiens_hsa034102.45716645
10Mismatch repair_Homo sapiens_hsa034302.32080769
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.18921018
12DNA replication_Homo sapiens_hsa030301.97127278
13Osteoclast differentiation_Homo sapiens_hsa043801.89175372
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74123390
15Leishmaniasis_Homo sapiens_hsa051401.68442731
16T cell receptor signaling pathway_Homo sapiens_hsa046601.64706512
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59826476
18Non-homologous end-joining_Homo sapiens_hsa034501.52195913
19Herpes simplex infection_Homo sapiens_hsa051681.43717744
20Tuberculosis_Homo sapiens_hsa051521.36495109
21Epstein-Barr virus infection_Homo sapiens_hsa051691.35253691
22Chemokine signaling pathway_Homo sapiens_hsa040621.30979998
23Homologous recombination_Homo sapiens_hsa034401.28536643
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23593231
25Measles_Homo sapiens_hsa051621.22695119
26Rheumatoid arthritis_Homo sapiens_hsa053231.22457393
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17890568
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.14724352
29Shigellosis_Homo sapiens_hsa051311.12024869
30Non-small cell lung cancer_Homo sapiens_hsa052231.05342108
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98565797
32Viral myocarditis_Homo sapiens_hsa054160.97841108
33Nucleotide excision repair_Homo sapiens_hsa034200.96454022
34Hepatitis B_Homo sapiens_hsa051610.95771199
35NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95200600
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94798577
37Influenza A_Homo sapiens_hsa051640.93549856
38African trypanosomiasis_Homo sapiens_hsa051430.93216631
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92398134
40Platelet activation_Homo sapiens_hsa046110.91259056
41Apoptosis_Homo sapiens_hsa042100.89763365
42Fanconi anemia pathway_Homo sapiens_hsa034600.85325747
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84946314
44Toxoplasmosis_Homo sapiens_hsa051450.83491674
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82752096
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.81312205
47Viral carcinogenesis_Homo sapiens_hsa052030.80541220
48Pancreatic cancer_Homo sapiens_hsa052120.79707620
49Phagosome_Homo sapiens_hsa041450.79447727
50Allograft rejection_Homo sapiens_hsa053300.77960308
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76360547
52HTLV-I infection_Homo sapiens_hsa051660.74434140
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73706726
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.73423107
55Spliceosome_Homo sapiens_hsa030400.70623298
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68124296
57Ribosome_Homo sapiens_hsa030100.66784367
58Pentose phosphate pathway_Homo sapiens_hsa000300.63015606
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61644388
60Salmonella infection_Homo sapiens_hsa051320.57624196
61Chronic myeloid leukemia_Homo sapiens_hsa052200.57034713
62TNF signaling pathway_Homo sapiens_hsa046680.56791596
63p53 signaling pathway_Homo sapiens_hsa041150.56676508
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52268681
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51977945
66Acute myeloid leukemia_Homo sapiens_hsa052210.51415877
67Inositol phosphate metabolism_Homo sapiens_hsa005620.50881443
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49847352
69Hepatitis C_Homo sapiens_hsa051600.48134997
70MAPK signaling pathway_Homo sapiens_hsa040100.47468994
71Malaria_Homo sapiens_hsa051440.47399742
72Graft-versus-host disease_Homo sapiens_hsa053320.46997215
73VEGF signaling pathway_Homo sapiens_hsa043700.45744025
74Pertussis_Homo sapiens_hsa051330.45619988
75Autoimmune thyroid disease_Homo sapiens_hsa053200.41868661
76Systemic lupus erythematosus_Homo sapiens_hsa053220.41712564
77MicroRNAs in cancer_Homo sapiens_hsa052060.41263220
78Cell cycle_Homo sapiens_hsa041100.41094412
79Small cell lung cancer_Homo sapiens_hsa052220.40584337
80Lysine degradation_Homo sapiens_hsa003100.37346084
81Endocytosis_Homo sapiens_hsa041440.34881469
82Prolactin signaling pathway_Homo sapiens_hsa049170.34015589
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32817128
84Glioma_Homo sapiens_hsa052140.32344106
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31700230
86Type I diabetes mellitus_Homo sapiens_hsa049400.31650229
87RNA degradation_Homo sapiens_hsa030180.31649171
88mRNA surveillance pathway_Homo sapiens_hsa030150.31280749
89FoxO signaling pathway_Homo sapiens_hsa040680.30646252
90Legionellosis_Homo sapiens_hsa051340.30467132
91Other glycan degradation_Homo sapiens_hsa005110.29403947
92Proteoglycans in cancer_Homo sapiens_hsa052050.29158140
93Renal cell carcinoma_Homo sapiens_hsa052110.29115127
94Notch signaling pathway_Homo sapiens_hsa043300.28356957
95Colorectal cancer_Homo sapiens_hsa052100.26560635
96Long-term potentiation_Homo sapiens_hsa047200.26521367
97mTOR signaling pathway_Homo sapiens_hsa041500.25243584
98Alcoholism_Homo sapiens_hsa050340.24417981
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.24160892
100Insulin resistance_Homo sapiens_hsa049310.23350700
101Choline metabolism in cancer_Homo sapiens_hsa052310.21454562
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21097081
103Dorso-ventral axis formation_Homo sapiens_hsa043200.20730146
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20546977
105Prostate cancer_Homo sapiens_hsa052150.19590455
106Pyrimidine metabolism_Homo sapiens_hsa002400.18009789
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.17905815
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16541456
109HIF-1 signaling pathway_Homo sapiens_hsa040660.15295211
110RNA transport_Homo sapiens_hsa030130.14077374
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14020514
112Endometrial cancer_Homo sapiens_hsa052130.13203928
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12495728
114GnRH signaling pathway_Homo sapiens_hsa049120.12478876
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11466351
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11252364
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09157498
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07925507
119ErbB signaling pathway_Homo sapiens_hsa040120.06351080

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »