MRPS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.52682828
2DNA deamination (GO:0045006)4.96322269
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.75971824
4DNA strand elongation involved in DNA replication (GO:0006271)4.52001131
5maturation of SSU-rRNA (GO:0030490)4.46099415
6chaperone-mediated protein transport (GO:0072321)4.44012509
7viral transcription (GO:0019083)4.39189200
8DNA strand elongation (GO:0022616)4.38321097
9telomere maintenance via semi-conservative replication (GO:0032201)4.36665300
10translational termination (GO:0006415)4.32308999
11ATP synthesis coupled proton transport (GO:0015986)4.27351453
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27351453
13formation of translation preinitiation complex (GO:0001731)4.24918600
14ribosomal small subunit biogenesis (GO:0042274)4.21266329
15DNA replication initiation (GO:0006270)4.08955565
16proteasome assembly (GO:0043248)4.08025358
17DNA unwinding involved in DNA replication (GO:0006268)4.06626787
18translational elongation (GO:0006414)4.01897078
19oxidative phosphorylation (GO:0006119)3.97039396
20nucleobase biosynthetic process (GO:0046112)3.91370796
21histone exchange (GO:0043486)3.85963809
22telomere maintenance via recombination (GO:0000722)3.80624335
23DNA replication checkpoint (GO:0000076)3.78145623
24ribosomal large subunit biogenesis (GO:0042273)3.78130475
25purine nucleobase biosynthetic process (GO:0009113)3.72759127
26IMP biosynthetic process (GO:0006188)3.72663141
27translational initiation (GO:0006413)3.67861520
28ribonucleoprotein complex biogenesis (GO:0022613)3.66351659
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63557850
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62929488
31CENP-A containing nucleosome assembly (GO:0034080)3.62135618
32chromatin remodeling at centromere (GO:0031055)3.60529354
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59457256
34mitotic recombination (GO:0006312)3.57806458
35cotranslational protein targeting to membrane (GO:0006613)3.56986323
36ribosome assembly (GO:0042255)3.54557861
37protein targeting to ER (GO:0045047)3.52283082
38telomere maintenance via telomere lengthening (GO:0010833)3.50278974
39ribosome biogenesis (GO:0042254)3.45680815
40IMP metabolic process (GO:0046040)3.45487117
41cellular protein complex disassembly (GO:0043624)3.45240636
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43886222
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.40782817
44NADH dehydrogenase complex assembly (GO:0010257)3.40782817
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40782817
46protein neddylation (GO:0045116)3.39293835
47regulation of mitotic spindle checkpoint (GO:1903504)3.39041758
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39041758
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38039122
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37976969
51DNA double-strand break processing (GO:0000729)3.37655162
52establishment of integrated proviral latency (GO:0075713)3.37456166
53rRNA processing (GO:0006364)3.36131788
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35831138
55protein localization to endoplasmic reticulum (GO:0070972)3.35618877
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.35452001
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35267080
58viral life cycle (GO:0019058)3.31937716
59cellular component biogenesis (GO:0044085)3.31902483
60* translation (GO:0006412)3.30378947
61regulation of mitochondrial translation (GO:0070129)3.29486420
62pseudouridine synthesis (GO:0001522)3.28606395
63metaphase plate congression (GO:0051310)3.27791131
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25129272
65negative regulation of ligase activity (GO:0051352)3.25129272
66establishment of protein localization to mitochondrial membrane (GO:0090151)3.24703728
67respiratory electron transport chain (GO:0022904)3.24353675
68establishment of viral latency (GO:0019043)3.23618645
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23199239
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.23199239
71rRNA metabolic process (GO:0016072)3.22724149
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21173684
73protein targeting to mitochondrion (GO:0006626)3.18729715
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18564871
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18564871
76DNA replication-independent nucleosome organization (GO:0034724)3.17386120
77DNA replication-independent nucleosome assembly (GO:0006336)3.17386120
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16745598
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16745598
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16745598
81electron transport chain (GO:0022900)3.16029434
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15943223
83positive regulation of ligase activity (GO:0051351)3.15276577
84spliceosomal snRNP assembly (GO:0000387)3.15109012
85regulation of cellular amino acid metabolic process (GO:0006521)3.14631915
86signal transduction involved in DNA damage checkpoint (GO:0072422)3.13226870
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13226870
88respiratory chain complex IV assembly (GO:0008535)3.11791670
89attachment of spindle microtubules to kinetochore (GO:0008608)3.09205235
90protein localization to kinetochore (GO:0034501)3.09183364
91spindle checkpoint (GO:0031577)3.09069030
92signal transduction involved in cell cycle checkpoint (GO:0072395)3.08019025
93protein complex biogenesis (GO:0070271)3.07863152
94mitochondrial respiratory chain complex assembly (GO:0033108)3.07757092
95transcription-coupled nucleotide-excision repair (GO:0006283)3.07599924
96rRNA modification (GO:0000154)3.07496824
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07265953
98tricarboxylic acid cycle (GO:0006099)3.06485086
99termination of RNA polymerase III transcription (GO:0006386)3.06180131
100transcription elongation from RNA polymerase III promoter (GO:0006385)3.06180131
101mitotic metaphase plate congression (GO:0007080)3.05988314
102DNA ligation (GO:0006266)3.05862749
103mitotic spindle checkpoint (GO:0071174)3.05660830
104negative regulation of mitotic sister chromatid separation (GO:2000816)3.05171292
105negative regulation of sister chromatid segregation (GO:0033046)3.05171292
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05171292
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05171292
108negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05171292
109protein complex disassembly (GO:0043241)3.04761850
110* DNA damage response, detection of DNA damage (GO:0042769)3.04533348
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.01307812
112cullin deneddylation (GO:0010388)2.98091616
113protein deneddylation (GO:0000338)2.97600252
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97526405
115viral mRNA export from host cell nucleus (GO:0046784)2.97358492
116nucleobase-containing small molecule interconversion (GO:0015949)2.96441642
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95069657
118kinetochore organization (GO:0051383)2.94050859
119G1/S transition of mitotic cell cycle (GO:0000082)2.92450621
120cell cycle G1/S phase transition (GO:0044843)2.92450621
121macromolecular complex disassembly (GO:0032984)2.92079499
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90982103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.23810420
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37119616
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94307273
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79567930
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.61929870
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42408754
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.30822277
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27520652
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.22910578
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06643540
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00967791
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90889104
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89972225
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86789200
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70340887
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.65281085
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61999070
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59984032
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59860581
20VDR_23849224_ChIP-Seq_CD4+_Human2.53228406
21XRN2_22483619_ChIP-Seq_HELA_Human2.38886860
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35841324
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35144677
24FOXP3_21729870_ChIP-Seq_TREG_Human2.34194627
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29808629
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24339170
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.23168936
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21066313
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11252438
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.11123102
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.02547002
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97197892
33GABP_19822575_ChIP-Seq_HepG2_Human1.96139906
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94540321
35TTF2_22483619_ChIP-Seq_HELA_Human1.86398803
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85380098
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83995458
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83388312
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81667774
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81066892
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78277000
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78073469
43CIITA_25753668_ChIP-Seq_RAJI_Human1.77124979
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76735401
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76164175
46ELK1_19687146_ChIP-ChIP_HELA_Human1.74211236
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73030718
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69139893
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.67228628
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67159232
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66565956
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62033146
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.60351741
54AR_21909140_ChIP-Seq_LNCAP_Human1.57898855
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55478600
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47333984
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41814229
58EWS_26573619_Chip-Seq_HEK293_Human1.36889529
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36615194
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.36467301
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34692419
62FUS_26573619_Chip-Seq_HEK293_Human1.34056488
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32199957
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30788517
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28115913
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24615985
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23650031
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.23461865
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23140675
70KDM5A_27292631_Chip-Seq_BREAST_Human1.22346647
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22256897
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21446044
73ZNF274_21170338_ChIP-Seq_K562_Hela1.17257612
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.16383860
75* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09841421
76MYC_22102868_ChIP-Seq_BL_Human1.08971674
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08537015
78* FLI1_27457419_Chip-Seq_LIVER_Mouse1.08232340
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06622350
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05057222
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04484136
82VDR_22108803_ChIP-Seq_LS180_Human1.03734010
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03611297
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02359398
85TFEB_21752829_ChIP-Seq_HELA_Human0.99794200
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97780499
87SPI1_23547873_ChIP-Seq_NB4_Human0.97202316
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92767909
89MYC_18940864_ChIP-ChIP_HL60_Human0.92317354
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92264297
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.92076815
92EGR1_19374776_ChIP-ChIP_THP-1_Human0.91044583
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.89776229
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89653764
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89575597
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89042016
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89041632
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87735093
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84728241
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84672875
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83503502
102IRF1_19129219_ChIP-ChIP_H3396_Human0.81985618
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81962865
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81620938
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81468808
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79252641
107IGF1R_20145208_ChIP-Seq_DFB_Human0.78229900
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77961718
109* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76887454
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76266937
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76154079
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75157051
113VDR_21846776_ChIP-Seq_THP-1_Human0.74763724
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74471907
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74093658
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73590324
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73293083
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73293083
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73293083
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72300799
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71513530
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71380492
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.71079754
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70469771
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70387384
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69713922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.43627278
2MP0010094_abnormal_chromosome_stability4.35813048
3MP0004957_abnormal_blastocyst_morpholog4.12761698
4MP0008057_abnormal_DNA_replication3.96371615
5MP0003111_abnormal_nucleus_morphology3.79668540
6MP0003077_abnormal_cell_cycle3.46693087
7MP0008058_abnormal_DNA_repair3.38859808
8MP0003646_muscle_fatigue3.03582699
9MP0002396_abnormal_hematopoietic_system2.78150375
10MP0003806_abnormal_nucleotide_metabolis2.74342884
11MP0006036_abnormal_mitochondrial_physio2.72226054
12MP0002837_dystrophic_cardiac_calcinosis2.71787275
13MP0004084_abnormal_cardiac_muscle2.52523549
14MP0003941_abnormal_skin_development2.48993760
15MP0008877_abnormal_DNA_methylation2.45511525
16MP0003123_paternal_imprinting2.39621179
17MP0008007_abnormal_cellular_replicative2.29701907
18MP0001293_anophthalmia2.26257925
19MP0004215_abnormal_myocardial_fiber2.21503252
20MP0003786_premature_aging2.18118746
21MP0008932_abnormal_embryonic_tissue2.16436272
22MP0006035_abnormal_mitochondrial_morpho2.02270155
23MP0003136_yellow_coat_color1.99039415
24MP0001730_embryonic_growth_arrest1.93238792
25MP0003567_abnormal_fetal_cardiomyocyte1.91651091
26MP0009379_abnormal_foot_pigmentation1.80198480
27MP0003221_abnormal_cardiomyocyte_apopto1.79577294
28MP0005330_cardiomyopathy1.69919982
29MP0006072_abnormal_retinal_apoptosis1.69159408
30MP0002938_white_spotting1.67939828
31MP0001529_abnormal_vocalization1.66737698
32MP0003890_abnormal_embryonic-extraembry1.66686424
33MP0008789_abnormal_olfactory_epithelium1.65894670
34MP0000749_muscle_degeneration1.62056903
35MP0010030_abnormal_orbit_morphology1.55499487
36MP0000350_abnormal_cell_proliferation1.54374251
37MP0000372_irregular_coat_pigmentation1.50516949
38MP0004036_abnormal_muscle_relaxation1.50246409
39MP0003186_abnormal_redox_activity1.48731193
40MP0001188_hyperpigmentation1.48315850
41MP0004145_abnormal_muscle_electrophysio1.47860634
42MP0003763_abnormal_thymus_physiology1.46014173
43MP0000313_abnormal_cell_death1.41691929
44MP0004808_abnormal_hematopoietic_stem1.41228136
45MP0005266_abnormal_metabolism1.40976067
46MP0001697_abnormal_embryo_size1.40636157
47MP0003122_maternal_imprinting1.40458680
48MP0003937_abnormal_limbs/digits/tail_de1.39468161
49MP0002080_prenatal_lethality1.36569128
50MP0002269_muscular_atrophy1.32827921
51MP0001286_abnormal_eye_development1.31076307
52MP0000490_abnormal_crypts_of1.31042998
53MP0005380_embryogenesis_phenotype1.29840605
54MP0001672_abnormal_embryogenesis/_devel1.29840605
55MP0003984_embryonic_growth_retardation1.29156111
56MP0002019_abnormal_tumor_incidence1.25658475
57MP0009333_abnormal_splenocyte_physiolog1.25293826
58MP0000049_abnormal_middle_ear1.25115138
59MP0000751_myopathy1.24443509
60MP0002163_abnormal_gland_morphology1.24071773
61MP0002102_abnormal_ear_morphology1.23971999
62MP0002088_abnormal_embryonic_growth/wei1.23426129
63MP0004147_increased_porphyrin_level1.23300001
64MP0003119_abnormal_digestive_system1.22704217
65MP0003828_pulmonary_edema1.22485817
66MP0001544_abnormal_cardiovascular_syste1.21230779
67MP0005385_cardiovascular_system_phenoty1.21230779
68MP0002398_abnormal_bone_marrow1.20885494
69MP0002233_abnormal_nose_morphology1.19696927
70MP0005499_abnormal_olfactory_system1.17700871
71MP0005394_taste/olfaction_phenotype1.17700871
72MP0002697_abnormal_eye_size1.15828975
73MP0000358_abnormal_cell_content/1.15029901
74MP0006292_abnormal_olfactory_placode1.14790350
75MP0002722_abnormal_immune_system1.12940498
76MP0000689_abnormal_spleen_morphology1.12933478
77MP0010630_abnormal_cardiac_muscle1.12179705
78MP0000703_abnormal_thymus_morphology1.11992872
79MP0002127_abnormal_cardiovascular_syste1.09609941
80MP0003121_genomic_imprinting1.07811459
81MP0005075_abnormal_melanosome_morpholog1.06759167
82MP0002736_abnormal_nociception_after1.04776682
83MP0002106_abnormal_muscle_physiology1.03989620
84MP0002972_abnormal_cardiac_muscle1.02584432
85MP0002234_abnormal_pharynx_morphology1.02216990
86MP0003787_abnormal_imprinting1.02108317
87MP0002132_abnormal_respiratory_system1.01606794
88MP0001835_abnormal_antigen_presentation1.00961007
89MP0002210_abnormal_sex_determination1.00830026
90MP0003315_abnormal_perineum_morphology1.00652323
91MP0005084_abnormal_gallbladder_morpholo1.00127707
92MP0009672_abnormal_birth_weight0.99915310
93MP0002160_abnormal_reproductive_system0.99856718
94MP0001853_heart_inflammation0.99687241
95MP0008775_abnormal_heart_ventricle0.99664780
96MP0003137_abnormal_impulse_conducting0.99222763
97MP0002429_abnormal_blood_cell0.98514018
98MP0004233_abnormal_muscle_weight0.97052604
99MP0001764_abnormal_homeostasis0.95255023
100MP0000750_abnormal_muscle_regeneration0.94792562
101MP0004087_abnormal_muscle_fiber0.94251012
102MP0002086_abnormal_extraembryonic_tissu0.93670838
103MP0002085_abnormal_embryonic_tissue0.93302539
104MP0009697_abnormal_copulation0.92589961
105MP0004133_heterotaxia0.90431629
106MP0000647_abnormal_sebaceous_gland0.90068869
107MP0002111_abnormal_tail_morphology0.88162097
108MP0001984_abnormal_olfaction0.87884079
109MP0000631_abnormal_neuroendocrine_gland0.86737655
110MP0006138_congestive_heart_failure0.86383195
111MP0001485_abnormal_pinna_reflex0.85338172
112MP0001145_abnormal_male_reproductive0.85277351
113MP0005671_abnormal_response_to0.84880151
114MP0005174_abnormal_tail_pigmentation0.84542240
115MP0003755_abnormal_palate_morphology0.84460148
116MP0001929_abnormal_gametogenesis0.82832908
117MP0000716_abnormal_immune_system0.82774874
118MP0008995_early_reproductive_senescence0.81417862
119MP0005397_hematopoietic_system_phenotyp0.81309433
120MP0001545_abnormal_hematopoietic_system0.81309433
121MP0002084_abnormal_developmental_patter0.81152938
122MP0003718_maternal_effect0.80887832
123MP0009785_altered_susceptibility_to0.79619652
124MP0001727_abnormal_embryo_implantation0.79552935
125MP0005379_endocrine/exocrine_gland_phen0.78913495
126MP0000343_altered_response_to0.78578225
127MP0005391_vision/eye_phenotype0.78210996
128MP0004484_altered_response_of0.77889102
129MP0003938_abnormal_ear_development0.77564600
130MP0002254_reproductive_system_inflammat0.77425709
131MP0002090_abnormal_vision0.77271181
132MP0002095_abnormal_skin_pigmentation0.76548108
133MP0005253_abnormal_eye_physiology0.76397155
134MP0001800_abnormal_humoral_immune0.75629499
135MP0004197_abnormal_fetal_growth/weight/0.74435113
136MP0002751_abnormal_autonomic_nervous0.73095604
137MP0010307_abnormal_tumor_latency0.72539536
138MP0002420_abnormal_adaptive_immunity0.69483561
139MP0005369_muscle_phenotype0.67892364
140MP0004142_abnormal_muscle_tone0.67656541
141MP0000653_abnormal_sex_gland0.67369225
142MP0001819_abnormal_immune_cell0.67011768
143MP0005376_homeostasis/metabolism_phenot0.66778616
144MP0003011_delayed_dark_adaptation0.66202256
145MP0001119_abnormal_female_reproductive0.66146000
146MP0009703_decreased_birth_body0.66057580
147MP0005332_abnormal_amino_acid0.65618105
148MP0005620_abnormal_muscle_contractility0.65120407
149MP0000759_abnormal_skeletal_muscle0.64230410
150MP0002092_abnormal_eye_morphology0.61853802
151MP0003385_abnormal_body_wall0.60895710

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.97237227
2Abnormal mitochondria in muscle tissue (HP:0008316)4.78225197
3Reticulocytopenia (HP:0001896)4.42529276
4Mitochondrial inheritance (HP:0001427)4.38384396
5Hepatocellular necrosis (HP:0001404)4.30658830
6Increased CSF lactate (HP:0002490)4.28574006
7Hepatic necrosis (HP:0002605)4.24816460
8Birth length less than 3rd percentile (HP:0003561)4.13826255
9Acute encephalopathy (HP:0006846)4.12816295
10Abnormality of cells of the erythroid lineage (HP:0012130)4.11579290
11Abnormal number of erythroid precursors (HP:0012131)4.02622123
12Progressive macrocephaly (HP:0004481)3.93636035
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.81106807
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.81106807
15Increased hepatocellular lipid droplets (HP:0006565)3.68330939
16Increased serum lactate (HP:0002151)3.66738097
17Lipid accumulation in hepatocytes (HP:0006561)3.65606131
18Abnormality of glycolysis (HP:0004366)3.40660512
19Increased serum pyruvate (HP:0003542)3.40660512
20Abnormality of the labia minora (HP:0012880)3.39906336
21Lactic acidosis (HP:0003128)3.38547883
22Exercise intolerance (HP:0003546)3.37616638
23Cerebral edema (HP:0002181)3.31739087
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.29965876
25Microvesicular hepatic steatosis (HP:0001414)3.25531363
26Increased intramyocellular lipid droplets (HP:0012240)3.15521558
27Breast hypoplasia (HP:0003187)3.06178891
28Increased muscle lipid content (HP:0009058)3.05118188
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99683920
30Macrocytic anemia (HP:0001972)2.91706418
31Chromsome breakage (HP:0040012)2.89865533
32Respiratory failure (HP:0002878)2.87110445
33Aplastic anemia (HP:0001915)2.79928378
34Exertional dyspnea (HP:0002875)2.79300560
35Thrombocytosis (HP:0001894)2.77182800
36Rhabdomyolysis (HP:0003201)2.76232802
37Pallor (HP:0000980)2.73323358
38Oral leukoplakia (HP:0002745)2.72407047
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72222170
403-Methylglutaconic aciduria (HP:0003535)2.71409691
41Respiratory difficulties (HP:0002880)2.69692592
42Colon cancer (HP:0003003)2.59942192
43Abnormality of alanine metabolism (HP:0010916)2.54505851
44Hyperalaninemia (HP:0003348)2.54505851
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54505851
46Methylmalonic acidemia (HP:0002912)2.50297796
47IgM deficiency (HP:0002850)2.50045207
48Ragged-red muscle fibers (HP:0003200)2.47158593
49Palpitations (HP:0001962)2.46832513
50Abnormality of methionine metabolism (HP:0010901)2.45287283
51Renal Fanconi syndrome (HP:0001994)2.45112057
52Abnormality of the preputium (HP:0100587)2.38948706
53Selective tooth agenesis (HP:0001592)2.35731068
54Patellar aplasia (HP:0006443)2.35103105
55Hyperglycinemia (HP:0002154)2.32374209
56Pancytopenia (HP:0001876)2.31334441
57Reduced antithrombin III activity (HP:0001976)2.30470484
58Leukodystrophy (HP:0002415)2.30247224
59Abnormality of serum amino acid levels (HP:0003112)2.27428544
60Rough bone trabeculation (HP:0100670)2.27400307
61Absent thumb (HP:0009777)2.24669860
62Myelodysplasia (HP:0002863)2.24349837
63Septo-optic dysplasia (HP:0100842)2.23468551
64Nausea (HP:0002018)2.23082489
65Abnormality of chromosome stability (HP:0003220)2.22892514
66Carpal bone hypoplasia (HP:0001498)2.21294533
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20787894
68Stenosis of the external auditory canal (HP:0000402)2.20172717
69Triphalangeal thumb (HP:0001199)2.19157394
7011 pairs of ribs (HP:0000878)2.18568582
71Dicarboxylic aciduria (HP:0003215)2.18067393
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18067393
73Aplasia/Hypoplasia of the patella (HP:0006498)2.17357174
74Microretrognathia (HP:0000308)2.16604924
75CNS demyelination (HP:0007305)2.12872915
76Emotional lability (HP:0000712)2.12868712
77Methylmalonic aciduria (HP:0012120)2.08971313
78Meckel diverticulum (HP:0002245)2.08544256
79Facial cleft (HP:0002006)2.04221331
80Bone marrow hypocellularity (HP:0005528)2.04108325
81Abnormal protein N-linked glycosylation (HP:0012347)2.04016130
82Abnormal protein glycosylation (HP:0012346)2.04016130
83Abnormal glycosylation (HP:0012345)2.04016130
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04016130
85Abnormality of the ileum (HP:0001549)2.03104021
86Agnosia (HP:0010524)2.02915361
87Small intestinal stenosis (HP:0012848)2.01561146
88Duodenal stenosis (HP:0100867)2.01561146
89Duplicated collecting system (HP:0000081)2.00133204
90Horseshoe kidney (HP:0000085)1.99877164
91Optic disc pallor (HP:0000543)1.99681644
92Multiple enchondromatosis (HP:0005701)1.98724598
93Premature graying of hair (HP:0002216)1.98409759
94Exercise-induced muscle cramps (HP:0003710)1.97808004
95Cerebral hypomyelination (HP:0006808)1.95584177
96Medulloblastoma (HP:0002885)1.93867429
97Generalized aminoaciduria (HP:0002909)1.93779335
98Megaloblastic anemia (HP:0001889)1.92155681
99Lethargy (HP:0001254)1.91534019
100Myoglobinuria (HP:0002913)1.91438005
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.89031323
102Abnormality of the duodenum (HP:0002246)1.89014755
103Ependymoma (HP:0002888)1.88844173
104Type I transferrin isoform profile (HP:0003642)1.87123171
105Cellular immunodeficiency (HP:0005374)1.85500973
106Ventricular tachycardia (HP:0004756)1.85005237
107Absent septum pellucidum (HP:0001331)1.84715464
108Type 2 muscle fiber atrophy (HP:0003554)1.84018409
109Muscle fiber atrophy (HP:0100295)1.83822929
110Abnormality of the renal collecting system (HP:0004742)1.83198058
111Hyperglycinuria (HP:0003108)1.82633333
112Sloping forehead (HP:0000340)1.81546699
113Abnormality of serine family amino acid metabolism (HP:0010894)1.81187732
114Abnormality of glycine metabolism (HP:0010895)1.81187732
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.80613041
116Asplenia (HP:0001746)1.79480989
117Abnormality of reticulocytes (HP:0004312)1.79465843
118Lymphoma (HP:0002665)1.79346134
119Degeneration of anterior horn cells (HP:0002398)1.78781436
120Abnormality of the anterior horn cell (HP:0006802)1.78781436
121Gliosis (HP:0002171)1.78752886
122Progressive external ophthalmoplegia (HP:0000590)1.78562801
123Volvulus (HP:0002580)1.77653293
124Abnormal lung lobation (HP:0002101)1.77218805
125X-linked dominant inheritance (HP:0001423)1.75201552
126Abnormality of fatty-acid metabolism (HP:0004359)1.74617436
127Sparse eyelashes (HP:0000653)1.74306920
128Unsteady gait (HP:0002317)1.74238760
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73693156
130Nephroblastoma (Wilms tumor) (HP:0002667)1.73132661
131Median cleft lip (HP:0000161)1.72824274
132Pancreatic fibrosis (HP:0100732)1.70444486
133Embryonal renal neoplasm (HP:0011794)1.68639207
134Glycosuria (HP:0003076)1.68412561
135Abnormality of urine glucose concentration (HP:0011016)1.68412561
136Gout (HP:0001997)1.67905380
137Congenital, generalized hypertrichosis (HP:0004540)1.66541093
138Abnormality of the pons (HP:0007361)1.64510016
139Abnormality of the septum pellucidum (HP:0007375)1.63400084
140Abnormality of renal resorption (HP:0011038)1.63255729
141Hypoplasia of the pons (HP:0012110)1.62939570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.25428508
2WEE14.02710287
3VRK23.56313044
4CDC73.05418722
5PBK2.96373214
6MST42.96179525
7NME22.95234605
8EIF2AK12.82334192
9SRPK12.72050868
10NEK12.54478814
11TAF12.51287237
12STK162.48244902
13BCKDK2.28501038
14TSSK62.12844655
15NUAK12.09011690
16PLK42.02514895
17PDK31.98882586
18PDK41.98882586
19TTK1.92605791
20FLT31.92244916
21TNIK1.87132635
22TRIM281.87059050
23NEK21.68620141
24PLK11.68164470
25CCNB11.66908223
26EIF2AK31.66584952
27WNK31.65856874
28VRK11.63517517
29PASK1.63306570
30BRSK21.60897841
31TAOK21.57538879
32ZAK1.56050384
33MYLK1.55872120
34TLK11.46870194
35ATR1.42758567
36TGFBR11.42651336
37ACVR1B1.42205356
38RPS6KB21.41905155
39MAP4K11.41073479
40AURKB1.36170369
41PKN21.34747885
42NME11.31356512
43MAP3K121.28610270
44MAP2K31.24072481
45DYRK31.23203765
46MAP4K21.19932192
47CDK191.18371366
48BMPR1B1.17445482
49MAP2K61.16167636
50PDK21.13444882
51DYRK21.12879185
52PLK31.09800747
53CDK71.08695979
54BRSK11.07142187
55SCYL21.01880505
56CHEK21.00659073
57TXK1.00424875
58BCR0.98277338
59PLK20.97897435
60CDK40.95890755
61KDR0.93832826
62STK240.93055438
63AURKA0.92824162
64DAPK10.92331448
65MAP3K80.92325750
66GRK10.90837560
67GRK60.89378492
68ILK0.88745421
69PINK10.88381451
70ZAP700.87675727
71MKNK10.87013901
72OBSCN0.86736222
73EIF2AK20.86537857
74TESK20.86209222
75PIM20.86062555
76CDK80.85971425
77ALK0.85401076
78STK40.84890427
79BRAF0.80501897
80GRK70.76760837
81RPS6KA40.75189301
82MUSK0.74811732
83CSNK2A20.74535066
84PAK40.73804036
85CHEK10.71956893
86IRAK40.71396817
87BLK0.70814439
88CSNK2A10.69998981
89KIT0.69916798
90CSNK1G10.69823874
91MAP3K110.69172849
92TEC0.68404420
93CSNK1E0.67463729
94TTN0.63853859
95PIM10.62698541
96STK100.59687764
97PNCK0.56955725
98FGFR10.54002686
99ATM0.53767514
100ERBB30.53509905
101MAP3K50.53395220
102CSNK1G30.51984728
103OXSR10.51418267
104MAP3K100.50200259
105MAP3K40.49587718
106STK38L0.49405836
107CLK10.48360216
108MAP2K70.48020185
109CSNK1G20.47406095
110CSF1R0.47231641
111BTK0.46932527
112MAPKAPK30.46422921
113STK30.46320654
114CDK20.46122596
115TIE10.45735306
116SYK0.45367193
117BRD40.45247421
118MKNK20.44173150
119ERBB40.41246347
120MAPK110.41007617
121CASK0.40869688
122PAK10.40618410
123YES10.40150410
124AKT20.39623364
125ARAF0.37657445
126PRKDC0.36844047
127MINK10.36525340
128PRKCI0.35732853
129PRKCG0.35166019
130TYK20.34354013
131DAPK30.33053268
132EEF2K0.32785745
133RPS6KA50.32568624
134CSNK1A10.32474204
135LIMK10.32439481
136CDK10.31927023
137LYN0.31720577
138CSNK1A1L0.30594492
139NLK0.30340064
140CDK30.29882902
141MARK30.26498319
142PRKACB0.24150097

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43375457
2* Ribosome_Homo sapiens_hsa030104.09754299
3Proteasome_Homo sapiens_hsa030504.00544212
4Mismatch repair_Homo sapiens_hsa034303.88747456
5RNA polymerase_Homo sapiens_hsa030203.20788565
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12561475
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90639226
8Oxidative phosphorylation_Homo sapiens_hsa001902.80231950
9Parkinsons disease_Homo sapiens_hsa050122.78961836
10Spliceosome_Homo sapiens_hsa030402.71736929
11Homologous recombination_Homo sapiens_hsa034402.70193306
12Base excision repair_Homo sapiens_hsa034102.58502093
13Pyrimidine metabolism_Homo sapiens_hsa002402.56395615
14Nucleotide excision repair_Homo sapiens_hsa034202.41673812
15RNA transport_Homo sapiens_hsa030132.40132292
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23702255
17Huntingtons disease_Homo sapiens_hsa050162.11700347
18One carbon pool by folate_Homo sapiens_hsa006701.99294774
19Non-homologous end-joining_Homo sapiens_hsa034501.96667246
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85279617
21Cell cycle_Homo sapiens_hsa041101.85209082
22RNA degradation_Homo sapiens_hsa030181.82139646
23Fanconi anemia pathway_Homo sapiens_hsa034601.78208686
24Alzheimers disease_Homo sapiens_hsa050101.75824302
25Basal transcription factors_Homo sapiens_hsa030221.58931753
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54375519
27Carbon metabolism_Homo sapiens_hsa012001.53754857
28Purine metabolism_Homo sapiens_hsa002301.42067373
29Steroid biosynthesis_Homo sapiens_hsa001001.29601353
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27227379
31Cardiac muscle contraction_Homo sapiens_hsa042601.22026814
32Biosynthesis of amino acids_Homo sapiens_hsa012301.20394190
33Pentose phosphate pathway_Homo sapiens_hsa000301.19411360
34Propanoate metabolism_Homo sapiens_hsa006401.11201024
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.06040210
36mRNA surveillance pathway_Homo sapiens_hsa030151.04005820
37Pyruvate metabolism_Homo sapiens_hsa006201.00360289
38Epstein-Barr virus infection_Homo sapiens_hsa051690.99899502
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95957495
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94097624
41Fructose and mannose metabolism_Homo sapiens_hsa000510.89456620
42Protein export_Homo sapiens_hsa030600.86531029
43Folate biosynthesis_Homo sapiens_hsa007900.83829215
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83605197
45p53 signaling pathway_Homo sapiens_hsa041150.81673178
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81088163
47Primary immunodeficiency_Homo sapiens_hsa053400.80801455
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.76693612
49Butanoate metabolism_Homo sapiens_hsa006500.75894980
50Sulfur relay system_Homo sapiens_hsa041220.73510726
51Systemic lupus erythematosus_Homo sapiens_hsa053220.69287151
52Herpes simplex infection_Homo sapiens_hsa051680.65907254
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64613420
54Glutathione metabolism_Homo sapiens_hsa004800.64262048
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63883472
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63166011
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62677294
58Metabolic pathways_Homo sapiens_hsa011000.59095307
59Fatty acid degradation_Homo sapiens_hsa000710.57915046
60Oocyte meiosis_Homo sapiens_hsa041140.53419196
61Selenocompound metabolism_Homo sapiens_hsa004500.51259803
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49728524
63Galactose metabolism_Homo sapiens_hsa000520.49659026
64Fatty acid elongation_Homo sapiens_hsa000620.49609996
65Antigen processing and presentation_Homo sapiens_hsa046120.49458875
66Phototransduction_Homo sapiens_hsa047440.49446008
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45261154
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45064322
69Viral carcinogenesis_Homo sapiens_hsa052030.44587253
70Sulfur metabolism_Homo sapiens_hsa009200.43615040
71Caffeine metabolism_Homo sapiens_hsa002320.41939637
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40893208
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40640497
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40521960
75Hedgehog signaling pathway_Homo sapiens_hsa043400.39583421
76Basal cell carcinoma_Homo sapiens_hsa052170.39456496
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39433476
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39253211
79Tryptophan metabolism_Homo sapiens_hsa003800.39247110
80Chemical carcinogenesis_Homo sapiens_hsa052040.37946462
81Retinol metabolism_Homo sapiens_hsa008300.36843909
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36838917
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36686262
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36149359
85Regulation of autophagy_Homo sapiens_hsa041400.34740956
86Nitrogen metabolism_Homo sapiens_hsa009100.34596839
87Vitamin B6 metabolism_Homo sapiens_hsa007500.33336639
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32883997
89Fatty acid metabolism_Homo sapiens_hsa012120.31692301
90Legionellosis_Homo sapiens_hsa051340.28875146
91Arginine biosynthesis_Homo sapiens_hsa002200.28704061
92Vitamin digestion and absorption_Homo sapiens_hsa049770.28475603
93Tyrosine metabolism_Homo sapiens_hsa003500.28060820
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.27215586
95Wnt signaling pathway_Homo sapiens_hsa043100.26685858
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.26002045
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25975662
98HTLV-I infection_Homo sapiens_hsa051660.25834831
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24186329
100Measles_Homo sapiens_hsa051620.23833885
101Fat digestion and absorption_Homo sapiens_hsa049750.23075332
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.20376741
103HIF-1 signaling pathway_Homo sapiens_hsa040660.20355998
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19559755
105Collecting duct acid secretion_Homo sapiens_hsa049660.19181403
106Shigellosis_Homo sapiens_hsa051310.19148228
107Arginine and proline metabolism_Homo sapiens_hsa003300.17470632
108Peroxisome_Homo sapiens_hsa041460.17093422
109Hippo signaling pathway_Homo sapiens_hsa043900.15275227
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.14426997
111Thyroid cancer_Homo sapiens_hsa052160.14349926
112TGF-beta signaling pathway_Homo sapiens_hsa043500.12170320
113Phenylalanine metabolism_Homo sapiens_hsa003600.11613873
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.10616020
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10150376
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06773628
117Hematopoietic cell lineage_Homo sapiens_hsa046400.05983072
118Alcoholism_Homo sapiens_hsa050340.05710483
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.04885125
120Arachidonic acid metabolism_Homo sapiens_hsa005900.04820205
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04075585
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02810530
123N-Glycan biosynthesis_Homo sapiens_hsa005100.02560286
124Influenza A_Homo sapiens_hsa051640.02217627
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.01238209
126beta-Alanine metabolism_Homo sapiens_hsa004100.00872239
127Viral myocarditis_Homo sapiens_hsa054160.00301255
128Transcriptional misregulation in cancer_Homo sapiens_hsa05202-4.5234886
129Allograft rejection_Homo sapiens_hsa05330-0.0322137
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0227217
131Apoptosis_Homo sapiens_hsa04210-0.0195418

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