MRPS36P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.60694309
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.51992180
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.45747348
4ATP synthesis coupled proton transport (GO:0015986)5.45747348
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.77526162
6proteasome assembly (GO:0043248)4.54849359
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.41761177
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.41761177
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.36749037
10respiratory electron transport chain (GO:0022904)4.30551839
11electron transport chain (GO:0022900)4.28762806
12respiratory chain complex IV assembly (GO:0008535)4.20939940
13protein complex biogenesis (GO:0070271)4.12164167
14protein neddylation (GO:0045116)4.02910994
15water-soluble vitamin biosynthetic process (GO:0042364)4.02382698
16mitochondrial respiratory chain complex assembly (GO:0033108)3.95240620
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94979819
18cytochrome complex assembly (GO:0017004)3.89960193
19rRNA modification (GO:0000154)3.87063153
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.84356866
21regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.77902938
22positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.65415251
23regulation of cellular amino acid metabolic process (GO:0006521)3.54890079
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48099256
25cullin deneddylation (GO:0010388)3.47536006
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43590378
27chaperone-mediated protein transport (GO:0072321)3.40655061
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37491165
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.37491165
30NADH dehydrogenase complex assembly (GO:0010257)3.37491165
31rRNA methylation (GO:0031167)3.34594685
32preassembly of GPI anchor in ER membrane (GO:0016254)3.33386861
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29251943
34signal peptide processing (GO:0006465)3.28134403
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27913396
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23198847
37protein deneddylation (GO:0000338)3.22848630
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22492126
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22492126
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22492126
41RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21409173
42negative regulation of ligase activity (GO:0051352)3.20687732
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20687732
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18052062
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18052062
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.15245948
47termination of RNA polymerase III transcription (GO:0006386)3.15245948
48hydrogen ion transmembrane transport (GO:1902600)3.14879295
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.13959595
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.13959595
51isotype switching (GO:0045190)3.13959595
52mannosylation (GO:0097502)3.09754869
53proton transport (GO:0015992)3.09628429
54positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.06403672
55hydrogen transport (GO:0006818)3.06167409
56C-terminal protein lipidation (GO:0006501)3.05064722
57fucose catabolic process (GO:0019317)3.03794250
58L-fucose metabolic process (GO:0042354)3.03794250
59L-fucose catabolic process (GO:0042355)3.03794250
60protein-cofactor linkage (GO:0018065)3.03288509
61aldehyde catabolic process (GO:0046185)3.03065489
62GPI anchor biosynthetic process (GO:0006506)3.02600088
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02453524
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.02453524
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01770491
66protein localization to cilium (GO:0061512)3.00799098
67GPI anchor metabolic process (GO:0006505)3.00009237
68ATP biosynthetic process (GO:0006754)2.99801966
69signal transduction involved in cell cycle checkpoint (GO:0072395)2.98734565
70platelet dense granule organization (GO:0060155)2.98228968
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.97637306
72lactate metabolic process (GO:0006089)2.97589718
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97312695
74purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95739660
75cytidine deamination (GO:0009972)2.94337236
76cytidine metabolic process (GO:0046087)2.94337236
77cytidine catabolic process (GO:0006216)2.94337236
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94292258
79S-adenosylmethionine metabolic process (GO:0046500)2.91899485
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89316551
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88953920
82L-methionine biosynthetic process (GO:0071265)2.83774101
83amino acid salvage (GO:0043102)2.83774101
84L-methionine salvage (GO:0071267)2.83774101
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81345440
86ribosomal large subunit biogenesis (GO:0042273)2.77938983
87GTP biosynthetic process (GO:0006183)2.76844850
88positive regulation of ligase activity (GO:0051351)2.76121335
89organelle disassembly (GO:1903008)2.76112532
90C-terminal protein amino acid modification (GO:0018410)2.73991400
91tRNA processing (GO:0008033)2.72968681
92peptidyl-histidine modification (GO:0018202)2.71749707
93maturation of 5.8S rRNA (GO:0000460)2.70530328
94cellular ketone body metabolic process (GO:0046950)2.69858571
95DNA double-strand break processing (GO:0000729)2.69685483
96adenosine metabolic process (GO:0046085)2.62556845
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58710037
98regulation of mitotic spindle checkpoint (GO:1903504)2.58710037
99protein peptidyl-prolyl isomerization (GO:0000413)2.58280040
100histone mRNA metabolic process (GO:0008334)2.56307137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44693233
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94344087
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.43166950
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90377326
5VDR_22108803_ChIP-Seq_LS180_Human2.76998406
6ZNF274_21170338_ChIP-Seq_K562_Hela2.68898363
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.67071691
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57460164
9ELK1_19687146_ChIP-ChIP_HELA_Human2.57208718
10VDR_23849224_ChIP-Seq_CD4+_Human2.54016747
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39453350
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33019374
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14758875
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.13628472
15EWS_26573619_Chip-Seq_HEK293_Human2.12480218
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10530275
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08651486
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03603668
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95527415
20FOXP3_21729870_ChIP-Seq_TREG_Human1.92157321
21TAF15_26573619_Chip-Seq_HEK293_Human1.91823657
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89411437
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87125063
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86423323
25IGF1R_20145208_ChIP-Seq_DFB_Human1.85148028
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85097670
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81254027
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80680305
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79742675
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.74879211
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70084983
32P300_19829295_ChIP-Seq_ESCs_Human1.67559719
33FUS_26573619_Chip-Seq_HEK293_Human1.65877662
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65158308
35MYC_18940864_ChIP-ChIP_HL60_Human1.62132945
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62021004
37GBX2_23144817_ChIP-Seq_PC3_Human1.61559821
38TP53_22573176_ChIP-Seq_HFKS_Human1.60152121
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.56996661
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55336152
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.55300148
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49428713
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47397631
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47086564
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44491865
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43078266
47ER_23166858_ChIP-Seq_MCF-7_Human1.39263642
48DCP1A_22483619_ChIP-Seq_HELA_Human1.39018134
49SOX2_19829295_ChIP-Seq_ESCs_Human1.37672929
50NANOG_19829295_ChIP-Seq_ESCs_Human1.37672929
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33729158
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.33729158
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33253313
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.32182249
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30790844
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.29819183
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26558700
58GATA3_26560356_Chip-Seq_TH2_Human1.25929445
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.25873929
60AR_20517297_ChIP-Seq_VCAP_Human1.23368190
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23152072
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23039324
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19800681
64TCF4_22108803_ChIP-Seq_LS180_Human1.19691783
65CBP_20019798_ChIP-Seq_JUKART_Human1.19225126
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19225126
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19187983
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16842522
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.15143656
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14567465
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14271781
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13996289
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.12795483
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.12090128
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11863001
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10349649
77BCAT_22108803_ChIP-Seq_LS180_Human1.07412298
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.06092568
79HTT_18923047_ChIP-ChIP_STHdh_Human1.01957511
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.00598508
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99989259
82CDX2_22108803_ChIP-Seq_LS180_Human0.99963381
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99673250
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98901104
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98699873
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98523872
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98444069
88NCOR_22424771_ChIP-Seq_293T_Human0.98151827
89GABP_19822575_ChIP-Seq_HepG2_Human0.96773680
90AR_25329375_ChIP-Seq_VCAP_Human0.92728439
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92644636
92SALL4_22934838_ChIP-ChIP_CD34+_Human0.91948027
93TTF2_22483619_ChIP-Seq_HELA_Human0.91583858
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91505818
95P53_22387025_ChIP-Seq_ESCs_Mouse0.91053847
96ERG_20517297_ChIP-Seq_VCAP_Human0.91031994
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90770210
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.90139113
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89634698
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89073621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.24393997
2MP0005671_abnormal_response_to2.84780254
3MP0002837_dystrophic_cardiac_calcinosis2.76663768
4MP0006072_abnormal_retinal_apoptosis2.75171589
5MP0002102_abnormal_ear_morphology2.69770894
6MP0005084_abnormal_gallbladder_morpholo2.45633318
7MP0005075_abnormal_melanosome_morpholog2.43989246
8MP0003195_calcinosis2.40259722
9MP0005367_renal/urinary_system_phenotyp2.32302618
10MP0000516_abnormal_urinary_system2.32302618
11MP0008877_abnormal_DNA_methylation2.30925121
12MP0003806_abnormal_nucleotide_metabolis2.05339768
13MP0006036_abnormal_mitochondrial_physio2.05190375
14MP0002163_abnormal_gland_morphology2.02956361
15MP0000372_irregular_coat_pigmentation2.00205673
16MP0009785_altered_susceptibility_to1.98069194
17MP0000685_abnormal_immune_system1.94643672
18MP0008872_abnormal_physiological_respon1.91593105
19MP0002254_reproductive_system_inflammat1.89898020
20MP0002166_altered_tumor_susceptibility1.88237304
21MP0005379_endocrine/exocrine_gland_phen1.86312361
22MP0001529_abnormal_vocalization1.84498909
23MP0000569_abnormal_digit_pigmentation1.81266492
24MP0006054_spinal_hemorrhage1.67239691
25MP0008058_abnormal_DNA_repair1.64160000
26MP0009379_abnormal_foot_pigmentation1.62314549
27MP0003786_premature_aging1.60691279
28MP0001968_abnormal_touch/_nociception1.56757437
29MP0003724_increased_susceptibility_to1.55874842
30MP0002876_abnormal_thyroid_physiology1.55537414
31MP0009697_abnormal_copulation1.55215595
32MP0002006_tumorigenesis1.54734742
33MP0002736_abnormal_nociception_after1.52502939
34MP0002148_abnormal_hypersensitivity_rea1.43788190
35MP0003880_abnormal_central_pattern1.42150186
36MP0004142_abnormal_muscle_tone1.42104438
37MP0005645_abnormal_hypothalamus_physiol1.41475105
38MP0001790_abnormal_immune_system1.37231953
39MP0005387_immune_system_phenotype1.37231953
40MP0005636_abnormal_mineral_homeostasis1.36256253
41MP0005551_abnormal_eye_electrophysiolog1.36031094
42MP0009046_muscle_twitch1.30123959
43MP0008875_abnormal_xenobiotic_pharmacok1.29663564
44MP0001501_abnormal_sleep_pattern1.29478725
45MP0002938_white_spotting1.28749876
46MP0003252_abnormal_bile_duct1.28458749
47MP0003646_muscle_fatigue1.26949680
48MP0003787_abnormal_imprinting1.26441390
49MP0003186_abnormal_redox_activity1.26216912
50MP0005174_abnormal_tail_pigmentation1.24886516
51MP0006035_abnormal_mitochondrial_morpho1.23027137
52MP0001800_abnormal_humoral_immune1.21378980
53MP0005253_abnormal_eye_physiology1.20671611
54MP0009333_abnormal_splenocyte_physiolog1.19178879
55MP0002751_abnormal_autonomic_nervous1.17105000
56MP0005332_abnormal_amino_acid1.17017190
57MP0009764_decreased_sensitivity_to1.16496776
58MP0004147_increased_porphyrin_level1.16189526
59MP0004215_abnormal_myocardial_fiber1.13266440
60MP0001905_abnormal_dopamine_level1.10632994
61MP0008007_abnormal_cellular_replicative1.07503268
62MP0000427_abnormal_hair_cycle1.07469341
63MP0008995_early_reproductive_senescence1.06775063
64MP0006082_CNS_inflammation1.04582715
65MP0005000_abnormal_immune_tolerance1.02788290
66MP0001986_abnormal_taste_sensitivity1.01992049
67MP0001873_stomach_inflammation0.98585539
68MP0002138_abnormal_hepatobiliary_system0.98343378
69MP0001765_abnormal_ion_homeostasis0.97859715
70MP0002272_abnormal_nervous_system0.96576533
71MP0002693_abnormal_pancreas_physiology0.95938716
72MP0002723_abnormal_immune_serum0.94408208
73MP0001984_abnormal_olfaction0.93856014
74MP0003718_maternal_effect0.93769616
75MP0001485_abnormal_pinna_reflex0.93420034
76MP0002452_abnormal_antigen_presenting0.90434057
77MP0004145_abnormal_muscle_electrophysio0.89885323
78MP0001756_abnormal_urination0.89334494
79MP0004957_abnormal_blastocyst_morpholog0.89178770
80MP0009745_abnormal_behavioral_response0.85611039
81MP0005410_abnormal_fertilization0.85518621
82MP0005408_hypopigmentation0.85334547
83MP0003137_abnormal_impulse_conducting0.85011110
84MP0003890_abnormal_embryonic-extraembry0.84981694
85MP0005085_abnormal_gallbladder_physiolo0.84102950
86MP0010094_abnormal_chromosome_stability0.83550763
87MP0005319_abnormal_enzyme/_coenzyme0.83176103
88MP0001845_abnormal_inflammatory_respons0.82164127
89MP0001486_abnormal_startle_reflex0.81794018
90MP0006292_abnormal_olfactory_placode0.81163185
91MP0003693_abnormal_embryo_hatching0.79212770
92MP0001819_abnormal_immune_cell0.77038364
93MP0002420_abnormal_adaptive_immunity0.76565074
94MP0005389_reproductive_system_phenotype0.75142183
95MP0001919_abnormal_reproductive_system0.74578620
96MP0001727_abnormal_embryo_implantation0.73698713
97MP0005646_abnormal_pituitary_gland0.73399883
98MP0002095_abnormal_skin_pigmentation0.73102129
99MP0008775_abnormal_heart_ventricle0.72871426
100MP0001188_hyperpigmentation0.72782576

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.99769805
2Mitochondrial inheritance (HP:0001427)4.53654411
3Progressive macrocephaly (HP:0004481)4.52590686
4Abnormal mitochondria in muscle tissue (HP:0008316)4.40435660
5Increased CSF lactate (HP:0002490)4.24536097
6Hepatocellular necrosis (HP:0001404)4.24049306
7Acute encephalopathy (HP:0006846)4.18868523
83-Methylglutaconic aciduria (HP:0003535)3.97653001
9Hepatic necrosis (HP:0002605)3.89921327
10Methylmalonic acidemia (HP:0002912)3.71176149
11Congenital, generalized hypertrichosis (HP:0004540)3.70980204
12Increased hepatocellular lipid droplets (HP:0006565)3.70027058
13Lipid accumulation in hepatocytes (HP:0006561)3.56238162
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.49197810
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.49197810
16Cerebral edema (HP:0002181)3.16115430
17Exertional dyspnea (HP:0002875)3.15580540
18Stomatitis (HP:0010280)3.10967825
19Renal Fanconi syndrome (HP:0001994)3.00255279
20Methylmalonic aciduria (HP:0012120)2.99101187
21Hypoproteinemia (HP:0003075)2.86566038
22Pancreatic cysts (HP:0001737)2.80219391
23Aplastic anemia (HP:0001915)2.75579795
24Hypothermia (HP:0002045)2.71200607
25IgG deficiency (HP:0004315)2.68434091
26Increased serum lactate (HP:0002151)2.66793758
27Abolished electroretinogram (ERG) (HP:0000550)2.65144740
28Respiratory failure (HP:0002878)2.63178062
29Abnormality of vitamin B metabolism (HP:0004340)2.55871089
30Lactic acidosis (HP:0003128)2.54577143
31Renal cortical cysts (HP:0000803)2.52267976
32Abnormality of the renal cortex (HP:0011035)2.51318376
33Leukodystrophy (HP:0002415)2.49259399
34Increased intramyocellular lipid droplets (HP:0012240)2.40444999
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39940684
36Abnormality of midbrain morphology (HP:0002418)2.37446261
37Molar tooth sign on MRI (HP:0002419)2.37446261
38Optic disc pallor (HP:0000543)2.36457554
39Abnormality of urine glucose concentration (HP:0011016)2.35448074
40Glycosuria (HP:0003076)2.35448074
41B lymphocytopenia (HP:0010976)2.34246367
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32211532
43Nephronophthisis (HP:0000090)2.27507038
44Thyroiditis (HP:0100646)2.24306624
45Abnormality of the vitamin B12 metabolism (HP:0004341)2.21520824
46Abnormality of the prostate (HP:0008775)2.20649787
47Congenital stationary night blindness (HP:0007642)2.20300622
48Pancreatic fibrosis (HP:0100732)2.17970997
49Lethargy (HP:0001254)2.15140942
50Abnormality of B cell number (HP:0010975)2.14785858
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14372782
52Type I transferrin isoform profile (HP:0003642)2.12969230
53Abnormality of the pons (HP:0007361)2.12375575
54Large for gestational age (HP:0001520)2.11924097
55CNS demyelination (HP:0007305)2.10989417
56Palpitations (HP:0001962)2.04875719
57Abnormality of alanine metabolism (HP:0010916)2.03396172
58Hyperalaninemia (HP:0003348)2.03396172
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03396172
60Bile duct proliferation (HP:0001408)2.03050343
61Abnormal biliary tract physiology (HP:0012439)2.03050343
62Medial flaring of the eyebrow (HP:0010747)2.01976469
63Abnormal drinking behavior (HP:0030082)2.01824693
64Polydipsia (HP:0001959)2.01824693
65Generalized aminoaciduria (HP:0002909)2.01472245
66Exercise intolerance (HP:0003546)2.00538783
67Abnormality of renal resorption (HP:0011038)1.99822518
68Severe combined immunodeficiency (HP:0004430)1.99612586
69Degeneration of anterior horn cells (HP:0002398)1.99296234
70Abnormality of the anterior horn cell (HP:0006802)1.99296234
71True hermaphroditism (HP:0010459)1.98771080
72Increased muscle lipid content (HP:0009058)1.98746548
73Progressive microcephaly (HP:0000253)1.95427793
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94150375
75Abnormality of the renal medulla (HP:0100957)1.94019936
76Dicarboxylic aciduria (HP:0003215)1.87490622
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87490622
78Respiratory difficulties (HP:0002880)1.86719594
79Pancytopenia (HP:0001876)1.85569910
80Hypoplasia of the pons (HP:0012110)1.83625482
81Progressive inability to walk (HP:0002505)1.82867993
82Cleft eyelid (HP:0000625)1.82389381
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81279697
84Tubular atrophy (HP:0000092)1.76979332
85Intestinal atresia (HP:0011100)1.76508624
86Abnormality of serum amino acid levels (HP:0003112)1.75949249
87Abnormality of the ileum (HP:0001549)1.75527942
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75503789
89Abnormal protein N-linked glycosylation (HP:0012347)1.75503789
90Abnormal protein glycosylation (HP:0012346)1.75503789
91Abnormal glycosylation (HP:0012345)1.75503789
92Hyperglycinemia (HP:0002154)1.75373522
93Meckel diverticulum (HP:0002245)1.75179865
94Elevated erythrocyte sedimentation rate (HP:0003565)1.74901378
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.74798851
96Hypoplasia of the fovea (HP:0007750)1.74798851
97Azoospermia (HP:0000027)1.73154396
98Facial diplegia (HP:0001349)1.68603986
99X-linked dominant inheritance (HP:0001423)1.68310435
100Abnormality of methionine metabolism (HP:0010901)1.68153552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.69298688
2MAP4K23.28309480
3MAP3K123.27280404
4FRK3.26707791
5NUAK12.91261267
6TXK2.74210312
7EIF2AK32.72281757
8TLK12.44682557
9BMPR1B2.31582662
10ZAK2.26278811
11WNK32.17261826
12TAOK32.07616425
13ERBB31.90094709
14BMPR21.89815343
15GRK11.88265107
16PINK11.84303501
17TRIM281.72648813
18OXSR11.72645181
19ADRBK21.68314586
20STK161.58507027
21BUB11.53087037
22VRK21.49939118
23MYLK1.49922182
24PLK41.43410788
25TNIK1.40471898
26NEK11.36721778
27TSSK61.35746498
28WNK41.34461838
29PLK31.33353985
30EIF2AK11.31441081
31ACVR1B1.30554524
32VRK11.29389787
33MKNK21.21422050
34NME11.19781140
35CDK191.16374739
36SCYL21.15536671
37INSRR1.10259841
38PHKG21.08586765
39PHKG11.08586765
40TRPM71.06374809
41STK391.05445020
42MAPK130.98058557
43IKBKB0.97714896
44MAP2K60.97700499
45TEC0.96774099
46DAPK10.95686423
47EIF2AK20.93610077
48MKNK10.92874454
49SRPK10.91329833
50BCKDK0.89209268
51PLK20.88383566
52CSNK1G30.88016148
53CSNK1G10.84575061
54TIE10.82299846
55MAPKAPK30.78686250
56MAP4K10.77780330
57CSNK1G20.72176352
58STK30.71650206
59KIT0.69356979
60MAP3K140.62857018
61CSNK1A1L0.61378261
62FLT30.61350288
63DAPK20.60916347
64PRKCE0.58267539
65IKBKE0.57706219
66MAP3K40.56117123
67RPS6KA50.54402282
68CDC70.53866825
69ILK0.53690160
70TAF10.51963172
71PAK30.51886350
72PASK0.50993407
73ADRBK10.48832563
74LYN0.47905696
75SYK0.46258149
76DYRK20.45893202
77IGF1R0.45524794
78PNCK0.44375402
79ITK0.43995448
80WEE10.43349022
81PLK10.41969478
82ROCK10.41885068
83TTK0.41531457
84GRK70.41475270
85DAPK30.38539561
86MAPKAPK50.36720434
87PRKCQ0.34039091
88CSNK1A10.33960153
89MINK10.33698068
90ATR0.33184592
91CDK30.32996929
92CSNK2A10.32969179
93CASK0.32694887
94NLK0.32673540
95KDR0.32076801
96RPS6KA40.31642105
97LCK0.30506775
98CAMK2A0.30397449
99PRKACA0.29190765
100CSNK2A20.28802841

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.27691130
2Protein export_Homo sapiens_hsa030603.99206293
3Oxidative phosphorylation_Homo sapiens_hsa001903.82378403
4Asthma_Homo sapiens_hsa053103.59401364
5Parkinsons disease_Homo sapiens_hsa050123.06785004
6Allograft rejection_Homo sapiens_hsa053302.53415649
7Type I diabetes mellitus_Homo sapiens_hsa049402.47270884
8Autoimmune thyroid disease_Homo sapiens_hsa053202.39061519
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.33980166
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25000517
11Graft-versus-host disease_Homo sapiens_hsa053322.21427351
12Alzheimers disease_Homo sapiens_hsa050102.06195371
13RNA polymerase_Homo sapiens_hsa030201.97731979
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92481763
15Huntingtons disease_Homo sapiens_hsa050161.92244647
16Homologous recombination_Homo sapiens_hsa034401.86796651
17Ribosome_Homo sapiens_hsa030101.68100516
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60747224
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60587158
20Rheumatoid arthritis_Homo sapiens_hsa053231.55676543
21RNA degradation_Homo sapiens_hsa030181.51664401
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.49785121
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45987981
24Mismatch repair_Homo sapiens_hsa034301.39599717
25Antigen processing and presentation_Homo sapiens_hsa046121.35945531
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35435259
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34093561
28Propanoate metabolism_Homo sapiens_hsa006401.30869241
29Cardiac muscle contraction_Homo sapiens_hsa042601.24409845
30Phototransduction_Homo sapiens_hsa047441.20432168
31Fanconi anemia pathway_Homo sapiens_hsa034601.19600666
32Collecting duct acid secretion_Homo sapiens_hsa049661.17308141
33Basal transcription factors_Homo sapiens_hsa030221.15371713
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14772179
35Primary immunodeficiency_Homo sapiens_hsa053401.11913010
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10519343
37One carbon pool by folate_Homo sapiens_hsa006701.07675753
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01046107
39Tryptophan metabolism_Homo sapiens_hsa003800.95822958
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94530431
41Viral myocarditis_Homo sapiens_hsa054160.92776156
42Vitamin B6 metabolism_Homo sapiens_hsa007500.92437189
43RNA transport_Homo sapiens_hsa030130.91290143
44Sulfur metabolism_Homo sapiens_hsa009200.90651012
45Butanoate metabolism_Homo sapiens_hsa006500.87778375
46Regulation of autophagy_Homo sapiens_hsa041400.84368200
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82691541
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80179330
49Purine metabolism_Homo sapiens_hsa002300.79368820
50Pyrimidine metabolism_Homo sapiens_hsa002400.76823168
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76079287
52Linoleic acid metabolism_Homo sapiens_hsa005910.75892308
53Nitrogen metabolism_Homo sapiens_hsa009100.74914878
54Nucleotide excision repair_Homo sapiens_hsa034200.73741392
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.73677604
56Peroxisome_Homo sapiens_hsa041460.73375344
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71503641
58DNA replication_Homo sapiens_hsa030300.70712267
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69862156
60Spliceosome_Homo sapiens_hsa030400.67912047
61Ether lipid metabolism_Homo sapiens_hsa005650.66684730
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64428920
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60740403
64Non-homologous end-joining_Homo sapiens_hsa034500.60694328
65Selenocompound metabolism_Homo sapiens_hsa004500.60376520
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59773083
67Metabolic pathways_Homo sapiens_hsa011000.58862627
68Fatty acid elongation_Homo sapiens_hsa000620.56344215
69Caffeine metabolism_Homo sapiens_hsa002320.50874080
70Staphylococcus aureus infection_Homo sapiens_hsa051500.50826232
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50592127
72Chemical carcinogenesis_Homo sapiens_hsa052040.49103629
73Systemic lupus erythematosus_Homo sapiens_hsa053220.48082575
74Leishmaniasis_Homo sapiens_hsa051400.47080456
75Hematopoietic cell lineage_Homo sapiens_hsa046400.46850508
76Pyruvate metabolism_Homo sapiens_hsa006200.46530496
77Fatty acid degradation_Homo sapiens_hsa000710.45688113
78Folate biosynthesis_Homo sapiens_hsa007900.45531505
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45396441
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44486080
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.43159951
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42936385
83beta-Alanine metabolism_Homo sapiens_hsa004100.42605895
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37762259
85Retinol metabolism_Homo sapiens_hsa008300.36793997
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36664224
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34442617
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34340703
89Arachidonic acid metabolism_Homo sapiens_hsa005900.32776618
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32246209
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31831601
92Glutathione metabolism_Homo sapiens_hsa004800.31273015
93Epstein-Barr virus infection_Homo sapiens_hsa051690.26335563
94Olfactory transduction_Homo sapiens_hsa047400.25746656
95Serotonergic synapse_Homo sapiens_hsa047260.25627285
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25230055
97Steroid biosynthesis_Homo sapiens_hsa001000.24962779
98Fat digestion and absorption_Homo sapiens_hsa049750.24455578
99GABAergic synapse_Homo sapiens_hsa047270.23105693
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.22201401

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