MRPS31P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.26692024
2pyrimidine nucleobase catabolic process (GO:0006208)4.81443007
3protein localization to cilium (GO:0061512)3.98351119
4nucleobase catabolic process (GO:0046113)3.86915478
5L-fucose catabolic process (GO:0042355)3.76955761
6fucose catabolic process (GO:0019317)3.76955761
7L-fucose metabolic process (GO:0042354)3.76955761
8neural tube formation (GO:0001841)3.71999231
9behavioral response to nicotine (GO:0035095)3.66365742
10DNA double-strand break processing (GO:0000729)3.64093439
11nonmotile primary cilium assembly (GO:0035058)3.60664237
12negative regulation of telomere maintenance (GO:0032205)3.54356702
13presynaptic membrane assembly (GO:0097105)3.38409427
14regulation of telomere maintenance (GO:0032204)3.35682566
15intraciliary transport (GO:0042073)3.30147588
16seminiferous tubule development (GO:0072520)3.27496045
17cilium morphogenesis (GO:0060271)3.26651908
18replication fork processing (GO:0031297)3.25442968
19protein polyglutamylation (GO:0018095)3.25040725
20epithelial cilium movement (GO:0003351)3.21422817
21protein complex biogenesis (GO:0070271)3.20729841
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14211769
23histone H2A acetylation (GO:0043968)3.10973137
24preassembly of GPI anchor in ER membrane (GO:0016254)3.04329534
25piRNA metabolic process (GO:0034587)3.04190768
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99126662
27mitochondrial respiratory chain complex I assembly (GO:0032981)2.99126662
28NADH dehydrogenase complex assembly (GO:0010257)2.99126662
29negative regulation of translation, ncRNA-mediated (GO:0040033)2.99068292
30regulation of translation, ncRNA-mediated (GO:0045974)2.99068292
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99068292
32positive regulation of mitochondrial fission (GO:0090141)2.97258077
33mitochondrial respiratory chain complex assembly (GO:0033108)2.94409190
34cilium organization (GO:0044782)2.88606740
35presynaptic membrane organization (GO:0097090)2.88414658
36respiratory chain complex IV assembly (GO:0008535)2.86913630
37regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.82967887
38cilium assembly (GO:0042384)2.81648866
39detection of light stimulus involved in visual perception (GO:0050908)2.80778429
40detection of light stimulus involved in sensory perception (GO:0050962)2.80778429
41postsynaptic membrane organization (GO:0001941)2.80699081
42olfactory bulb development (GO:0021772)2.78844740
43sulfation (GO:0051923)2.77328650
44regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.77196605
45head development (GO:0060322)2.76303696
46regulation of cilium movement (GO:0003352)2.75749006
47axoneme assembly (GO:0035082)2.75343457
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73868312
49neuron cell-cell adhesion (GO:0007158)2.71919395
50photoreceptor cell maintenance (GO:0045494)2.71878102
51regulation of hexokinase activity (GO:1903299)2.71859997
52regulation of glucokinase activity (GO:0033131)2.71859997
53inositol phosphate catabolic process (GO:0071545)2.67631374
54DNA demethylation (GO:0080111)2.66178277
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63161976
56cytochrome complex assembly (GO:0017004)2.61865902
57pyrimidine dimer repair (GO:0006290)2.61555495
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61412375
59gamma-aminobutyric acid transport (GO:0015812)2.60240356
60DNA deamination (GO:0045006)2.57786796
61retinal ganglion cell axon guidance (GO:0031290)2.56359317
62reciprocal meiotic recombination (GO:0007131)2.54562680
63reciprocal DNA recombination (GO:0035825)2.54562680
64establishment of protein localization to Golgi (GO:0072600)2.54506299
65protein localization to synapse (GO:0035418)2.54193206
66protein K11-linked deubiquitination (GO:0035871)2.52523728
67DNA integration (GO:0015074)2.51878493
68recombinational repair (GO:0000725)2.50942118
69limb bud formation (GO:0060174)2.49737597
70auditory behavior (GO:0031223)2.49377516
71anterograde synaptic vesicle transport (GO:0048490)2.49346548
72neurotransmitter-gated ion channel clustering (GO:0072578)2.49266493
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48759830
74platelet dense granule organization (GO:0060155)2.48049737
75negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47907318
76behavioral response to ethanol (GO:0048149)2.47468004
77protein prenylation (GO:0018342)2.47243027
78prenylation (GO:0097354)2.47243027
79cilium movement (GO:0003341)2.47109890
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45470694
81mannosylation (GO:0097502)2.45388218
82synapsis (GO:0007129)2.44231023
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.44159313
84double-strand break repair via homologous recombination (GO:0000724)2.43430179
85GPI anchor metabolic process (GO:0006505)2.42837501
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41604522
87transmission of nerve impulse (GO:0019226)2.39978445
88mechanosensory behavior (GO:0007638)2.39634033
89resolution of meiotic recombination intermediates (GO:0000712)2.39283234
90iron-sulfur cluster assembly (GO:0016226)2.38260084
91metallo-sulfur cluster assembly (GO:0031163)2.38260084
92sympathetic nervous system development (GO:0048485)2.37931182
93rRNA catabolic process (GO:0016075)2.37747354
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36629870
95somite development (GO:0061053)2.36134362
96protein-cofactor linkage (GO:0018065)2.35667146
97DNA methylation involved in gamete generation (GO:0043046)2.35502332
98negative regulation of mast cell activation (GO:0033004)2.33257346
99inner ear receptor stereocilium organization (GO:0060122)2.32850498
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.32787229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.85200516
2IGF1R_20145208_ChIP-Seq_DFB_Human3.51309854
3GBX2_23144817_ChIP-Seq_PC3_Human3.16486450
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14999100
5VDR_22108803_ChIP-Seq_LS180_Human3.04989621
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.73279685
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61888903
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59268202
9FUS_26573619_Chip-Seq_HEK293_Human2.45677952
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38736490
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38585403
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38158816
13EWS_26573619_Chip-Seq_HEK293_Human2.32324559
14TAF15_26573619_Chip-Seq_HEK293_Human2.32240144
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30863455
16IRF1_19129219_ChIP-ChIP_H3396_Human2.13417796
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12300088
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08871548
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.07846796
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06361109
21P300_19829295_ChIP-Seq_ESCs_Human2.01558476
22EZH2_22144423_ChIP-Seq_EOC_Human1.99109088
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93094029
24ER_23166858_ChIP-Seq_MCF-7_Human1.93066241
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.82593463
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.79778779
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.73463272
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69521788
29CBP_20019798_ChIP-Seq_JUKART_Human1.69518685
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69518685
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67950267
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67637315
33VDR_23849224_ChIP-Seq_CD4+_Human1.60216873
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56150586
35ELK1_19687146_ChIP-ChIP_HELA_Human1.56078511
36SMAD4_21799915_ChIP-Seq_A2780_Human1.55602357
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55450368
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55040253
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54650932
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50797134
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.50361933
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50283241
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47311823
44STAT3_23295773_ChIP-Seq_U87_Human1.45928383
45MYC_18940864_ChIP-ChIP_HL60_Human1.44663267
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41647355
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41620424
48BCAT_22108803_ChIP-Seq_LS180_Human1.41599792
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40296305
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36772370
51TP53_22573176_ChIP-Seq_HFKS_Human1.36015051
52AR_25329375_ChIP-Seq_VCAP_Human1.35544983
53TCF4_23295773_ChIP-Seq_U87_Human1.35033215
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32895653
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32895653
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32463319
57RNF2_27304074_Chip-Seq_NSC_Mouse1.30651687
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30008106
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29745571
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27449841
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24490841
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23955396
63REST_21632747_ChIP-Seq_MESCs_Mouse1.23772055
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22683643
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21986509
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.21694903
67RUNX2_22187159_ChIP-Seq_PCA_Human1.20794973
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.20659499
69NANOG_19829295_ChIP-Seq_ESCs_Human1.20040541
70SOX2_19829295_ChIP-Seq_ESCs_Human1.20040541
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.19135437
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18362670
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17552480
74FOXP3_21729870_ChIP-Seq_TREG_Human1.15719236
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.14416035
76TCF4_22108803_ChIP-Seq_LS180_Human1.13237052
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11282505
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09569656
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.06578602
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05181615
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.05026217
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.03692267
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03634981
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02794345
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.02269630
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.01987812
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01525864
88NCOR_22424771_ChIP-Seq_293T_Human1.00480742
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99834428
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98522718
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97682449
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97454935
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.97182495
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96449733
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96335227
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95598203
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94500191
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.94228954
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94228954
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93471459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.31966669
2MP0003787_abnormal_imprinting3.02965343
3MP0008877_abnormal_DNA_methylation2.92547659
4MP0003880_abnormal_central_pattern2.85627016
5MP0001529_abnormal_vocalization2.48951364
6MP0006292_abnormal_olfactory_placode2.44191717
7MP0006072_abnormal_retinal_apoptosis2.28639776
8MP0003121_genomic_imprinting2.17981038
9MP0008058_abnormal_DNA_repair2.10774583
10MP0002837_dystrophic_cardiac_calcinosis2.06489256
11MP0005551_abnormal_eye_electrophysiolog2.04300996
12MP0003122_maternal_imprinting2.01706629
13MP0008789_abnormal_olfactory_epithelium1.93266310
14MP0005394_taste/olfaction_phenotype1.93107008
15MP0005499_abnormal_olfactory_system1.93107008
16MP0001984_abnormal_olfaction1.89612048
17MP0009046_muscle_twitch1.88642296
18MP0006276_abnormal_autonomic_nervous1.85332570
19MP0005253_abnormal_eye_physiology1.82274029
20MP0000569_abnormal_digit_pigmentation1.79028853
21MP0001968_abnormal_touch/_nociception1.75548889
22MP0005645_abnormal_hypothalamus_physiol1.67107452
23MP0002938_white_spotting1.62376737
24MP0001986_abnormal_taste_sensitivity1.62238774
25MP0000631_abnormal_neuroendocrine_gland1.61411512
26MP0005084_abnormal_gallbladder_morpholo1.59581873
27MP0005646_abnormal_pituitary_gland1.58412084
28MP0002751_abnormal_autonomic_nervous1.58016913
29MP0002272_abnormal_nervous_system1.52417747
30MP0001486_abnormal_startle_reflex1.51380110
31MP0000778_abnormal_nervous_system1.49963803
32MP0009745_abnormal_behavioral_response1.46328422
33MP0004142_abnormal_muscle_tone1.44120619
34MP0002638_abnormal_pupillary_reflex1.42282967
35MP0002736_abnormal_nociception_after1.36897792
36MP0003195_calcinosis1.36092491
37MP0000372_irregular_coat_pigmentation1.34889031
38MP0004133_heterotaxia1.32483945
39MP0001485_abnormal_pinna_reflex1.30682594
40MP0002822_catalepsy1.30524390
41MP0003635_abnormal_synaptic_transmissio1.30521024
42MP0002557_abnormal_social/conspecific_i1.25868716
43MP0005367_renal/urinary_system_phenotyp1.25808520
44MP0000516_abnormal_urinary_system1.25808520
45MP0001501_abnormal_sleep_pattern1.24442928
46MP0004924_abnormal_behavior1.23181746
47MP0005386_behavior/neurological_phenoty1.23181746
48MP0008995_early_reproductive_senescence1.19772472
49MP0002653_abnormal_ependyma_morphology1.18645354
50MP0004885_abnormal_endolymph1.18046288
51MP0002064_seizures1.15840982
52MP0002572_abnormal_emotion/affect_behav1.15270672
53MP0004742_abnormal_vestibular_system1.14946508
54MP0003890_abnormal_embryonic-extraembry1.12890717
55MP0001188_hyperpigmentation1.12537809
56MP0000427_abnormal_hair_cycle1.11197344
57MP0002067_abnormal_sensory_capabilities1.07306599
58MP0002184_abnormal_innervation1.06953175
59MP0002063_abnormal_learning/memory/cond1.05579863
60MP0008872_abnormal_physiological_respon1.05375045
61MP0002160_abnormal_reproductive_system1.04113282
62MP0003698_abnormal_male_reproductive1.03610630
63MP0006035_abnormal_mitochondrial_morpho1.03208692
64MP0002928_abnormal_bile_duct1.03008347
65MP0001929_abnormal_gametogenesis1.02857638
66MP0000049_abnormal_middle_ear1.02051512
67MP0004147_increased_porphyrin_level1.01838981
68MP0005187_abnormal_penis_morphology1.01813295
69MP0005174_abnormal_tail_pigmentation1.01717119
70MP0003718_maternal_effect1.01228668
71MP0002752_abnormal_somatic_nervous1.00448710
72MP0005423_abnormal_somatic_nervous0.99141086
73MP0001764_abnormal_homeostasis0.97825742
74MP0002735_abnormal_chemical_nociception0.96136262
75MP0003943_abnormal_hepatobiliary_system0.95578449
76MP0002233_abnormal_nose_morphology0.95376650
77MP0005075_abnormal_melanosome_morpholog0.95115602
78MP0001293_anophthalmia0.94512727
79MP0002882_abnormal_neuron_morphology0.92361432
80MP0004215_abnormal_myocardial_fiber0.91821405
81MP0003567_abnormal_fetal_cardiomyocyte0.91660413
82MP0005391_vision/eye_phenotype0.91229803
83MP0002876_abnormal_thyroid_physiology0.91161942
84MP0002210_abnormal_sex_determination0.90932523
85MP0005195_abnormal_posterior_eye0.88709433
86MP0000653_abnormal_sex_gland0.87588380
87MP0004270_analgesia0.87311150
88MP0004859_abnormal_synaptic_plasticity0.85703651
89MP0000955_abnormal_spinal_cord0.85341831
90MP0003646_muscle_fatigue0.83486445
91MP0005389_reproductive_system_phenotype0.82417314
92MP0002733_abnormal_thermal_nociception0.82080084
93MP0005410_abnormal_fertilization0.81254727
94MP0001324_abnormal_eye_pigmentation0.81212770
95MP0004811_abnormal_neuron_physiology0.80613388
96MP0001145_abnormal_male_reproductive0.79861120
97MP0008775_abnormal_heart_ventricle0.79838679
98MP0001970_abnormal_pain_threshold0.79538270
99MP0004043_abnormal_pH_regulation0.79460547
100MP0002095_abnormal_skin_pigmentation0.78109155

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.81055284
2True hermaphroditism (HP:0010459)3.70143707
3Abnormality of midbrain morphology (HP:0002418)3.63393562
4Molar tooth sign on MRI (HP:0002419)3.63393562
5Pancreatic fibrosis (HP:0100732)3.58021167
6Medial flaring of the eyebrow (HP:0010747)3.45104435
7Nephronophthisis (HP:0000090)3.16250034
8Gait imbalance (HP:0002141)3.15486570
9Congenital primary aphakia (HP:0007707)3.11185009
10Chronic hepatic failure (HP:0100626)3.02334026
11Abnormality of the labia minora (HP:0012880)2.99674914
12Nephrogenic diabetes insipidus (HP:0009806)2.98339881
13Type II lissencephaly (HP:0007260)2.86302099
14Abnormality of the renal medulla (HP:0100957)2.65396192
15Genital tract atresia (HP:0001827)2.64300805
16Absent speech (HP:0001344)2.63556789
17Vaginal atresia (HP:0000148)2.60066386
18Intestinal atresia (HP:0011100)2.57911718
19Cerebellar dysplasia (HP:0007033)2.48705821
20Retinal dysplasia (HP:0007973)2.47334464
21Protruding tongue (HP:0010808)2.46746920
22Inability to walk (HP:0002540)2.44128395
23Lissencephaly (HP:0001339)2.43901619
24Hyperventilation (HP:0002883)2.43729511
25Progressive cerebellar ataxia (HP:0002073)2.43285512
26Cystic liver disease (HP:0006706)2.41120022
27Volvulus (HP:0002580)2.30143570
28Abnormality of the renal cortex (HP:0011035)2.29837455
29Drooling (HP:0002307)2.24719286
30Poor coordination (HP:0002370)2.24357926
31Thyroiditis (HP:0100646)2.23250907
32Abolished electroretinogram (ERG) (HP:0000550)2.19665039
33Renal cortical cysts (HP:0000803)2.18901332
34Genetic anticipation (HP:0003743)2.17513682
35Progressive inability to walk (HP:0002505)2.16218286
36Pendular nystagmus (HP:0012043)2.16028294
37Pachygyria (HP:0001302)2.13430797
38Anencephaly (HP:0002323)2.11318207
39Congenital stationary night blindness (HP:0007642)2.10734836
40Gaze-evoked nystagmus (HP:0000640)2.08516462
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.07443622
42Excessive salivation (HP:0003781)2.02885933
43Oligodactyly (hands) (HP:0001180)2.02809925
44Male pseudohermaphroditism (HP:0000037)2.00261493
45Bile duct proliferation (HP:0001408)1.99890451
46Abnormal biliary tract physiology (HP:0012439)1.99890451
47Postaxial hand polydactyly (HP:0001162)1.99211254
48Widely spaced teeth (HP:0000687)1.98925687
49Occipital encephalocele (HP:0002085)1.95141279
50Hypothermia (HP:0002045)1.93243935
51Attenuation of retinal blood vessels (HP:0007843)1.92745626
52Broad-based gait (HP:0002136)1.91231383
53Sclerocornea (HP:0000647)1.90981648
543-Methylglutaconic aciduria (HP:0003535)1.90913321
55Abnormal rod and cone electroretinograms (HP:0008323)1.90826651
56Congenital hepatic fibrosis (HP:0002612)1.90622300
57Thyroid-stimulating hormone excess (HP:0002925)1.89115669
58Febrile seizures (HP:0002373)1.88151517
59Abnormal drinking behavior (HP:0030082)1.86800212
60Polydipsia (HP:0001959)1.86800212
61Mitochondrial inheritance (HP:0001427)1.86482642
62Postaxial foot polydactyly (HP:0001830)1.84723348
63Specific learning disability (HP:0001328)1.84465001
64Optic nerve hypoplasia (HP:0000609)1.79048902
65Narrow forehead (HP:0000341)1.78618151
66Astigmatism (HP:0000483)1.77347431
67Acute necrotizing encephalopathy (HP:0006965)1.77272939
68Polyphagia (HP:0002591)1.77054798
69Prominent nasal bridge (HP:0000426)1.76818170
70Preaxial hand polydactyly (HP:0001177)1.76327670
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.75868415
72Tubulointerstitial nephritis (HP:0001970)1.75590013
73Severe combined immunodeficiency (HP:0004430)1.75259908
74Abnormal hair whorl (HP:0010721)1.74744616
75Dialeptic seizures (HP:0011146)1.74225650
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.73393677
77Absent/shortened dynein arms (HP:0200106)1.73393677
78Progressive macrocephaly (HP:0004481)1.72707117
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72383572
80Hepatocellular necrosis (HP:0001404)1.72222153
81Sloping forehead (HP:0000340)1.70140032
82Increased CSF lactate (HP:0002490)1.69341763
83Abnormality of DNA repair (HP:0003254)1.68884600
84Focal seizures (HP:0007359)1.68714814
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68324146
86Abnormality of alanine metabolism (HP:0010916)1.67686634
87Hyperalaninemia (HP:0003348)1.67686634
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67686634
89Abnormal mitochondria in muscle tissue (HP:0008316)1.67574001
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.67312854
91Focal motor seizures (HP:0011153)1.66535161
92Hyperglycinuria (HP:0003108)1.66514962
93Aganglionic megacolon (HP:0002251)1.66181277
94Hyperglycinemia (HP:0002154)1.66080867
95Dandy-Walker malformation (HP:0001305)1.65295165
96Abnormality of the metopic suture (HP:0005556)1.64694628
97Scrotal hypoplasia (HP:0000046)1.63771656
98Decreased testicular size (HP:0008734)1.62331539
99Hepatic necrosis (HP:0002605)1.61826146
100Multicystic kidney dysplasia (HP:0000003)1.61365093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.63132180
2WNK33.56940174
3PINK13.19622267
4MAP4K23.01115974
5BMPR1B2.97149035
6CASK2.29295213
7MAPK132.08078898
8MAP3K42.04941600
9TRIM282.03573892
10TNIK2.02675827
11NUAK12.00740557
12BCR1.93313702
13ZAK1.81788899
14MAP2K71.80155826
15ADRBK21.76820849
16BRSK21.67196194
17ACVR1B1.66888265
18TAOK31.63114562
19MKNK21.60132459
20CSNK1G11.57621494
21CSNK1A1L1.57584041
22CSNK1G21.56004621
23DYRK21.55760649
24CSNK1G31.53257843
25OXSR11.40823915
26STK391.37132702
27GRK11.31497775
28STK38L1.29819254
29WNK41.27812851
30BCKDK1.26194391
31MARK11.26180872
32FGFR21.24880191
33PAK31.24513388
34MKNK11.20806387
35BRD41.10966472
36INSRR1.08390910
37CDK191.08136781
38EIF2AK31.06752330
39CCNB11.06330343
40NLK1.04842626
41PLK41.01200332
42MARK30.97691387
43TLK10.97626628
44EPHA30.93479245
45PIK3CA0.92713802
46TGFBR10.91165585
47WEE10.89970623
48VRK10.85780906
49TXK0.83629526
50PRKCE0.83463785
51ERBB30.72604016
52TIE10.68801664
53DYRK30.68559810
54MINK10.68456636
55PRKCG0.68025446
56ATR0.64841251
57NTRK20.63998410
58UHMK10.63373197
59TEC0.63355093
60PLK20.62969799
61CDK30.62881854
62CAMKK20.62397980
63PLK30.62384063
64NEK20.61117542
65PRKCQ0.61038480
66SRPK10.60385815
67NTRK30.59609926
68ATM0.57904820
69PKN10.56717618
70SIK20.56585496
71FLT30.56061173
72EPHA40.54389477
73DYRK1A0.53839531
74CSNK1D0.52900622
75ADRBK10.50952429
76PLK10.50577461
77PASK0.48564211
78STK110.47505229
79CDK50.47187951
80MAP2K40.46670323
81OBSCN0.46137596
82PNCK0.44655326
83CSNK1A10.43128373
84RPS6KA50.42970698
85CAMK2A0.42549413
86SGK4940.41507675
87SGK2230.41507675
88DAPK20.39382943
89STK30.38966101
90SGK20.36685318
91PRKAA10.34927689
92RPS6KB10.34780423
93KIT0.34183057
94MAP2K60.33664965
95PRKACA0.33117665
96VRK20.32901048
97AKT30.32330520
98MAPKAPK50.31742870
99CSNK1E0.30068627
100CAMK10.28105812

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.11425379
2Phototransduction_Homo sapiens_hsa047442.87591527
3Butanoate metabolism_Homo sapiens_hsa006502.74070465
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.63000299
5Nicotine addiction_Homo sapiens_hsa050332.50218454
6Fanconi anemia pathway_Homo sapiens_hsa034602.39635368
7Protein export_Homo sapiens_hsa030602.38688340
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32624134
9Homologous recombination_Homo sapiens_hsa034402.26657445
10Basal transcription factors_Homo sapiens_hsa030222.24211106
11Non-homologous end-joining_Homo sapiens_hsa034502.21438757
12RNA polymerase_Homo sapiens_hsa030202.12730890
13Regulation of autophagy_Homo sapiens_hsa041402.08174155
14Propanoate metabolism_Homo sapiens_hsa006402.04102969
15Nitrogen metabolism_Homo sapiens_hsa009101.93776960
16RNA degradation_Homo sapiens_hsa030181.87769961
17Olfactory transduction_Homo sapiens_hsa047401.85510177
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82956380
19Selenocompound metabolism_Homo sapiens_hsa004501.79868365
20Oxidative phosphorylation_Homo sapiens_hsa001901.72006242
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70524297
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66324259
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65210507
24Collecting duct acid secretion_Homo sapiens_hsa049661.59355086
25Peroxisome_Homo sapiens_hsa041461.50107008
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49723988
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49527942
28Steroid biosynthesis_Homo sapiens_hsa001001.43893960
29Taste transduction_Homo sapiens_hsa047421.38800058
30Parkinsons disease_Homo sapiens_hsa050121.37165387
31GABAergic synapse_Homo sapiens_hsa047271.35746904
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.32739056
33Ether lipid metabolism_Homo sapiens_hsa005651.28709329
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27965188
35Linoleic acid metabolism_Homo sapiens_hsa005911.26779109
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23169626
37Morphine addiction_Homo sapiens_hsa050321.20341391
38Circadian entrainment_Homo sapiens_hsa047131.17272282
39Nucleotide excision repair_Homo sapiens_hsa034201.14116625
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11977924
41Circadian rhythm_Homo sapiens_hsa047101.08200704
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06252031
43Glutamatergic synapse_Homo sapiens_hsa047241.02474105
44beta-Alanine metabolism_Homo sapiens_hsa004101.02402656
45Insulin secretion_Homo sapiens_hsa049110.98556616
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95390919
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94434975
48ABC transporters_Homo sapiens_hsa020100.91787544
49Dopaminergic synapse_Homo sapiens_hsa047280.89352260
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88318479
51Huntingtons disease_Homo sapiens_hsa050160.88013349
52Primary immunodeficiency_Homo sapiens_hsa053400.87540464
53RNA transport_Homo sapiens_hsa030130.87175081
54Amphetamine addiction_Homo sapiens_hsa050310.87077418
55Purine metabolism_Homo sapiens_hsa002300.84995673
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.84775629
57Mismatch repair_Homo sapiens_hsa034300.77984502
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76873218
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75918430
60Base excision repair_Homo sapiens_hsa034100.75815152
61Spliceosome_Homo sapiens_hsa030400.74984934
62Hedgehog signaling pathway_Homo sapiens_hsa043400.74217845
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68909341
64Pyrimidine metabolism_Homo sapiens_hsa002400.67652187
65Tryptophan metabolism_Homo sapiens_hsa003800.62362294
66Cocaine addiction_Homo sapiens_hsa050300.62187195
67Caffeine metabolism_Homo sapiens_hsa002320.62127057
68Serotonergic synapse_Homo sapiens_hsa047260.61769934
69Alzheimers disease_Homo sapiens_hsa050100.61505196
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61440154
71Chemical carcinogenesis_Homo sapiens_hsa052040.61067998
72Salivary secretion_Homo sapiens_hsa049700.59773747
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57265246
74Renin secretion_Homo sapiens_hsa049240.56045823
75mRNA surveillance pathway_Homo sapiens_hsa030150.55978831
76Metabolic pathways_Homo sapiens_hsa011000.53494605
77Fatty acid metabolism_Homo sapiens_hsa012120.53255355
78Calcium signaling pathway_Homo sapiens_hsa040200.52633891
79Synaptic vesicle cycle_Homo sapiens_hsa047210.52524468
80Cardiac muscle contraction_Homo sapiens_hsa042600.52512011
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.50954702
82Oocyte meiosis_Homo sapiens_hsa041140.48920114
83Fatty acid elongation_Homo sapiens_hsa000620.45495126
84One carbon pool by folate_Homo sapiens_hsa006700.44570528
85Retinol metabolism_Homo sapiens_hsa008300.43510204
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42967987
87Long-term depression_Homo sapiens_hsa047300.42100435
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.39376634
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38746253
90Axon guidance_Homo sapiens_hsa043600.38736822
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37895079
92Alcoholism_Homo sapiens_hsa050340.37531988
93Oxytocin signaling pathway_Homo sapiens_hsa049210.37443297
94cAMP signaling pathway_Homo sapiens_hsa040240.36561500
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35988227
96Cholinergic synapse_Homo sapiens_hsa047250.35400154
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32432355
98Basal cell carcinoma_Homo sapiens_hsa052170.32023824
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28962867
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28204987

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