MRPS31P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.94748565
2protein deneddylation (GO:0000338)4.21366252
3cullin deneddylation (GO:0010388)4.16675648
4DNA integration (GO:0015074)4.03372526
5respiratory chain complex IV assembly (GO:0008535)3.79921876
6proteasome assembly (GO:0043248)3.62021372
7lactate metabolic process (GO:0006089)3.61222732
8L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.55967912
9rRNA modification (GO:0000154)3.44243120
10nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41067636
11iron-sulfur cluster assembly (GO:0016226)3.39766600
12metallo-sulfur cluster assembly (GO:0031163)3.39766600
13establishment of integrated proviral latency (GO:0075713)3.38159032
14positive regulation of mitochondrial fission (GO:0090141)3.23895499
15ubiquinone biosynthetic process (GO:0006744)3.19829280
16non-recombinational repair (GO:0000726)3.19025620
17double-strand break repair via nonhomologous end joining (GO:0006303)3.19025620
18cytochrome complex assembly (GO:0017004)3.17444004
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15942759
20histone H2A acetylation (GO:0043968)3.15457922
21preassembly of GPI anchor in ER membrane (GO:0016254)3.10147249
22positive regulation of granulocyte differentiation (GO:0030854)3.10060119
23ubiquinone metabolic process (GO:0006743)3.09117212
24DNA ligation (GO:0006266)3.08388378
25pseudouridine synthesis (GO:0001522)3.07259147
26regulation of helicase activity (GO:0051095)3.06975414
27DNA deamination (GO:0045006)3.05899462
28mannosylation (GO:0097502)3.04777883
29spliceosomal snRNP assembly (GO:0000387)3.00487447
30pyrimidine nucleobase catabolic process (GO:0006208)2.99441317
31rRNA methylation (GO:0031167)2.99014802
32maturation of 5.8S rRNA (GO:0000460)2.98618721
33L-methionine biosynthetic process (GO:0071265)2.93481993
34amino acid salvage (GO:0043102)2.93481993
35L-methionine salvage (GO:0071267)2.93481993
36DNA catabolic process, exonucleolytic (GO:0000738)2.93051264
37protein polyglutamylation (GO:0018095)2.92383959
38regulation of cilium movement (GO:0003352)2.92234111
39DNA replication-dependent nucleosome organization (GO:0034723)2.90428536
40DNA replication-dependent nucleosome assembly (GO:0006335)2.90428536
41base-excision repair, AP site formation (GO:0006285)2.90167583
42platelet dense granule organization (GO:0060155)2.89127378
43establishment of viral latency (GO:0019043)2.88453453
44V(D)J recombination (GO:0033151)2.88237833
45response to pheromone (GO:0019236)2.82565833
46ribosome assembly (GO:0042255)2.81053937
47positive regulation of protein homodimerization activity (GO:0090073)2.80075858
48transcription from RNA polymerase III promoter (GO:0006383)2.79296154
49protein complex biogenesis (GO:0070271)2.77813252
507-methylguanosine mRNA capping (GO:0006370)2.73481019
51GPI anchor metabolic process (GO:0006505)2.71621092
52regulation of mitotic spindle checkpoint (GO:1903504)2.70898672
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70898672
54branched-chain amino acid catabolic process (GO:0009083)2.69046388
55recombinational repair (GO:0000725)2.68098095
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66971158
57transcription from mitochondrial promoter (GO:0006390)2.66281365
58peptidyl-histidine modification (GO:0018202)2.66167948
59double-strand break repair via homologous recombination (GO:0000724)2.66076579
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65662297
61mitochondrial respiratory chain complex assembly (GO:0033108)2.65527853
62tRNA aminoacylation (GO:0043039)2.65389463
63amino acid activation (GO:0043038)2.65389463
64RNA capping (GO:0036260)2.65142486
657-methylguanosine RNA capping (GO:0009452)2.65142486
66fucose catabolic process (GO:0019317)2.64776181
67L-fucose metabolic process (GO:0042354)2.64776181
68L-fucose catabolic process (GO:0042355)2.64776181
69tRNA aminoacylation for protein translation (GO:0006418)2.63708234
70regulation of oxidative stress-induced neuron death (GO:1903203)2.63685185
71somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63124526
72somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63124526
73isotype switching (GO:0045190)2.63124526
74somatic diversification of immune receptors (GO:0002200)2.62927087
75regulation of vacuole organization (GO:0044088)2.62503299
76water-soluble vitamin biosynthetic process (GO:0042364)2.62161959
77somatic cell DNA recombination (GO:0016444)2.62103651
78somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.62103651
79C-terminal protein amino acid modification (GO:0018410)2.60681385
80C-terminal protein lipidation (GO:0006501)2.60419896
81termination of RNA polymerase III transcription (GO:0006386)2.58342726
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.58342726
83regulation of autophagic vacuole assembly (GO:2000785)2.56773715
84anterograde synaptic vesicle transport (GO:0048490)2.56283509
85inositol phosphate catabolic process (GO:0071545)2.55616746
86GPI anchor biosynthetic process (GO:0006506)2.55605082
87neural tube formation (GO:0001841)2.55242766
88microtubule depolymerization (GO:0007019)2.54791502
89replication fork processing (GO:0031297)2.54396491
90intraciliary transport (GO:0042073)2.54344110
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53929902
92mitochondrial RNA metabolic process (GO:0000959)2.52699590
93ribonucleoprotein complex disassembly (GO:0032988)2.52317050
94short-chain fatty acid metabolic process (GO:0046459)2.52100795
95regulation of acyl-CoA biosynthetic process (GO:0050812)2.50781729
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.50195472
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.50195472
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.50195472
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.49360056
100protein localization to cilium (GO:0061512)2.49096481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.61073699
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29377915
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.00372717
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.57837533
5IGF1R_20145208_ChIP-Seq_DFB_Human3.55637732
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.39298357
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04305028
8ZNF274_21170338_ChIP-Seq_K562_Hela2.98449231
9VDR_23849224_ChIP-Seq_CD4+_Human2.96861991
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96544483
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91114039
12ELK1_19687146_ChIP-ChIP_HELA_Human2.79910510
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.74234917
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73211296
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58951022
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56307099
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50237646
18FOXP3_21729870_ChIP-Seq_TREG_Human2.44992033
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19042312
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.06012391
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05539137
22FUS_26573619_Chip-Seq_HEK293_Human1.99417487
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99171923
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.99159917
25GBX2_23144817_ChIP-Seq_PC3_Human1.94957156
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94833105
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86143964
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.83446421
29E2F7_22180533_ChIP-Seq_HELA_Human1.78063528
30DCP1A_22483619_ChIP-Seq_HELA_Human1.76244208
31EWS_26573619_Chip-Seq_HEK293_Human1.74971659
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71822114
33CIITA_25753668_ChIP-Seq_RAJI_Human1.70241460
34GABP_19822575_ChIP-Seq_HepG2_Human1.66092372
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.66006285
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63722654
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63245808
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61872440
39MYC_18940864_ChIP-ChIP_HL60_Human1.61403585
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53405994
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50012680
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46930024
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40701053
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.40624400
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37721994
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37644726
47ER_23166858_ChIP-Seq_MCF-7_Human1.35902620
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33808304
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31039396
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30561393
51IRF1_19129219_ChIP-ChIP_H3396_Human1.30499879
52P300_19829295_ChIP-Seq_ESCs_Human1.30076861
53KDM5A_27292631_Chip-Seq_BREAST_Human1.27459939
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25563654
55CBP_20019798_ChIP-Seq_JUKART_Human1.25563654
56VDR_22108803_ChIP-Seq_LS180_Human1.22522898
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.19379658
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18941781
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18892875
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17369320
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15680275
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13900155
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12140291
64TP53_22573176_ChIP-Seq_HFKS_Human1.12073704
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11480248
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06561015
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05788172
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05481063
69TTF2_22483619_ChIP-Seq_HELA_Human1.03836119
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03608132
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.01220352
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00714167
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00195329
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.99920740
75TAF15_26573619_Chip-Seq_HEK293_Human0.99811147
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98622624
77E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97100771
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95708116
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93932307
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.93094888
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92647894
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91304500
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91230910
84SMAD4_21799915_ChIP-Seq_A2780_Human0.87556873
85XRN2_22483619_ChIP-Seq_HELA_Human0.87330114
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87181268
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85319641
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85107275
89GATA3_26560356_Chip-Seq_TH2_Human0.84592132
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83687458
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82960223
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82605575
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.82427566
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81361231
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80080209
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.79409757
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77251641
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76683768
99NCOR_22424771_ChIP-Seq_293T_Human0.76033402
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73792938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.19523504
2MP0008058_abnormal_DNA_repair3.72363593
3MP0001529_abnormal_vocalization3.46198663
4MP0006072_abnormal_retinal_apoptosis3.20929521
5MP0010094_abnormal_chromosome_stability2.89758327
6MP0005394_taste/olfaction_phenotype2.65385739
7MP0005499_abnormal_olfactory_system2.65385739
8MP0008789_abnormal_olfactory_epithelium2.51440035
9MP0005075_abnormal_melanosome_morpholog2.49153225
10MP0009697_abnormal_copulation2.48909447
11MP0001984_abnormal_olfaction2.38980739
12MP0008877_abnormal_DNA_methylation2.32375705
13MP0003693_abnormal_embryo_hatching2.24667926
14MP0005253_abnormal_eye_physiology2.16943666
15MP0003718_maternal_effect2.13190225
16MP0000516_abnormal_urinary_system2.07484163
17MP0005367_renal/urinary_system_phenotyp2.07484163
18MP0003786_premature_aging2.07196920
19MP0006035_abnormal_mitochondrial_morpho2.02278884
20MP0002751_abnormal_autonomic_nervous1.98135045
21MP0003880_abnormal_central_pattern1.96204585
22MP0008007_abnormal_cellular_replicative1.94418895
23MP0000372_irregular_coat_pigmentation1.85664978
24MP0006036_abnormal_mitochondrial_physio1.73988586
25MP0006276_abnormal_autonomic_nervous1.71969094
26MP0002822_catalepsy1.70426279
27MP0003787_abnormal_imprinting1.65251274
28MP0003111_abnormal_nucleus_morphology1.64374611
29MP0003806_abnormal_nucleotide_metabolis1.61855608
30MP0005645_abnormal_hypothalamus_physiol1.60701530
31MP0001968_abnormal_touch/_nociception1.59717503
32MP0001986_abnormal_taste_sensitivity1.58828202
33MP0008995_early_reproductive_senescence1.57334866
34MP0002638_abnormal_pupillary_reflex1.54218685
35MP0003077_abnormal_cell_cycle1.48196651
36MP0004142_abnormal_muscle_tone1.43306194
37MP0003763_abnormal_thymus_physiology1.36994324
38MP0009046_muscle_twitch1.36838638
39MP0005551_abnormal_eye_electrophysiolog1.34441808
40MP0000465_gastrointestinal_hemorrhage1.32406192
41MP0002837_dystrophic_cardiac_calcinosis1.31310374
42MP0005646_abnormal_pituitary_gland1.27453715
43MP0001905_abnormal_dopamine_level1.20069363
44MP0003221_abnormal_cardiomyocyte_apopto1.19648309
45MP0001764_abnormal_homeostasis1.15505976
46MP0005410_abnormal_fertilization1.13508183
47MP0003121_genomic_imprinting1.11434230
48MP0001929_abnormal_gametogenesis1.08841031
49MP0008057_abnormal_DNA_replication1.06169429
50MP0005187_abnormal_penis_morphology1.05649767
51MP0004134_abnormal_chest_morphology1.02523159
52MP0001661_extended_life_span1.01075867
53MP0002160_abnormal_reproductive_system0.98776410
54MP0000569_abnormal_digit_pigmentation0.98680103
55MP0004924_abnormal_behavior0.97763472
56MP0005386_behavior/neurological_phenoty0.97763472
57MP0000631_abnormal_neuroendocrine_gland0.93650952
58MP0002132_abnormal_respiratory_system0.92224724
59MP0000358_abnormal_cell_content/0.91295545
60MP0008932_abnormal_embryonic_tissue0.89866351
61MP0004957_abnormal_blastocyst_morpholog0.89533675
62MP0002736_abnormal_nociception_after0.89208437
63MP0003698_abnormal_male_reproductive0.89059573
64MP0002909_abnormal_adrenal_gland0.89027199
65MP0001270_distended_abdomen0.86384092
66MP0002234_abnormal_pharynx_morphology0.85813917
67MP0005389_reproductive_system_phenotype0.84768286
68MP0004381_abnormal_hair_follicle0.82900652
69MP0005391_vision/eye_phenotype0.81844968
70MP0005220_abnormal_exocrine_pancreas0.81206990
71MP0002233_abnormal_nose_morphology0.79853849
72MP0008872_abnormal_physiological_respon0.79773036
73MP0002184_abnormal_innervation0.79224911
74MP0003315_abnormal_perineum_morphology0.77329706
75MP0001501_abnormal_sleep_pattern0.74557858
76MP0001919_abnormal_reproductive_system0.70990459
77MP0005266_abnormal_metabolism0.70783941
78MP0002090_abnormal_vision0.70157420
79MP0002019_abnormal_tumor_incidence0.70000449
80MP0002069_abnormal_eating/drinking_beha0.67774940
81MP0004197_abnormal_fetal_growth/weight/0.67388958
82MP0000015_abnormal_ear_pigmentation0.65976703
83MP0000703_abnormal_thymus_morphology0.65889288
84MP0004147_increased_porphyrin_level0.65526723
85MP0001145_abnormal_male_reproductive0.65325038
86MP0000653_abnormal_sex_gland0.64973829
87MP0002272_abnormal_nervous_system0.63936559
88MP0005395_other_phenotype0.63687425
89MP0002210_abnormal_sex_determination0.59601061
90MP0004811_abnormal_neuron_physiology0.58555859
91MP0000689_abnormal_spleen_morphology0.58196718
92MP0001119_abnormal_female_reproductive0.58069399
93MP0002166_altered_tumor_susceptibility0.57922960
94MP0002095_abnormal_skin_pigmentation0.57800871
95MP0002752_abnormal_somatic_nervous0.57501432
96MP0009745_abnormal_behavioral_response0.55993688
97MP0003122_maternal_imprinting0.55675062
98MP0008775_abnormal_heart_ventricle0.55537431
99MP0003656_abnormal_erythrocyte_physiolo0.55253206
100MP0001835_abnormal_antigen_presentation0.55226599

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.21739553
2Congenital primary aphakia (HP:0007707)3.20781381
3Abnormality of the labia minora (HP:0012880)3.13552899
4Gait imbalance (HP:0002141)3.10347955
5Medial flaring of the eyebrow (HP:0010747)3.05897236
6Nephrogenic diabetes insipidus (HP:0009806)3.03167370
7Hyperglycinemia (HP:0002154)2.94039023
8True hermaphroditism (HP:0010459)2.93661657
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.89958901
10Abnormal protein N-linked glycosylation (HP:0012347)2.89958901
11Abnormal protein glycosylation (HP:0012346)2.89958901
12Abnormal glycosylation (HP:0012345)2.89958901
13Progressive inability to walk (HP:0002505)2.87162245
14Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84205002
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84205002
16Lipid accumulation in hepatocytes (HP:0006561)2.78894616
17Hepatocellular necrosis (HP:0001404)2.77882821
18Thyroiditis (HP:0100646)2.76226629
19Severe combined immunodeficiency (HP:0004430)2.76048424
20Hypothermia (HP:0002045)2.73202900
21Tubulointerstitial nephritis (HP:0001970)2.65566531
22Pancreatic fibrosis (HP:0100732)2.64463202
23Chronic hepatic failure (HP:0100626)2.62422853
24Cerebral hypomyelination (HP:0006808)2.60699029
25Abnormality of midbrain morphology (HP:0002418)2.51529962
26Molar tooth sign on MRI (HP:0002419)2.51529962
27Renal cortical cysts (HP:0000803)2.48284266
28Inability to walk (HP:0002540)2.47249839
29Nephronophthisis (HP:0000090)2.46509359
30Hepatic necrosis (HP:0002605)2.43740050
31Abnormality of chromosome stability (HP:0003220)2.38209232
32Methylmalonic acidemia (HP:0002912)2.33332838
33Increased CSF lactate (HP:0002490)2.32415896
34Failure to thrive in infancy (HP:0001531)2.31089845
35Poor coordination (HP:0002370)2.30608749
36Abnormal biliary tract physiology (HP:0012439)2.28478798
37Bile duct proliferation (HP:0001408)2.28478798
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.27569636
39Mitochondrial inheritance (HP:0001427)2.27490600
40Increased hepatocellular lipid droplets (HP:0006565)2.26720586
41Combined immunodeficiency (HP:0005387)2.16784536
42CNS hypomyelination (HP:0003429)2.16187492
43Sloping forehead (HP:0000340)2.15116640
44Meckel diverticulum (HP:0002245)2.12955404
45Increased serum lactate (HP:0002151)2.12334363
46Intestinal atresia (HP:0011100)2.11691142
47Brushfield spots (HP:0001088)2.11093224
48Abnormality of the ileum (HP:0001549)2.11055411
49Retinal dysplasia (HP:0007973)2.08875618
50Vaginal atresia (HP:0000148)2.07943979
513-Methylglutaconic aciduria (HP:0003535)2.07215916
52Type I transferrin isoform profile (HP:0003642)2.06594793
53Genital tract atresia (HP:0001827)2.06177088
54Abnormality of the metopic suture (HP:0005556)2.05708616
55Reduced antithrombin III activity (HP:0001976)2.04922903
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01605541
57Absent speech (HP:0001344)1.98842118
58Progressive microcephaly (HP:0000253)1.96955322
59B lymphocytopenia (HP:0010976)1.96721067
60Abnormality of the renal medulla (HP:0100957)1.95887770
61Lissencephaly (HP:0001339)1.95187482
62IgG deficiency (HP:0004315)1.93771125
63Methylmalonic aciduria (HP:0012120)1.93440330
64Cerebellar dysplasia (HP:0007033)1.93381959
65Acute necrotizing encephalopathy (HP:0006965)1.91127225
66Abnormality of the renal cortex (HP:0011035)1.90037285
67Acute encephalopathy (HP:0006846)1.89522137
68Neoplasm of the adrenal cortex (HP:0100641)1.87801944
69Microvesicular hepatic steatosis (HP:0001414)1.87481403
70Prominent metopic ridge (HP:0005487)1.86704749
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86225690
72Abnormality of eosinophils (HP:0001879)1.85469909
73Progressive macrocephaly (HP:0004481)1.85302197
74Postaxial foot polydactyly (HP:0001830)1.85037607
75Abnormality of the pancreatic islet cells (HP:0006476)1.84248187
76Abnormality of endocrine pancreas physiology (HP:0012093)1.84248187
77Medulloblastoma (HP:0002885)1.83575670
78Lactic acidosis (HP:0003128)1.83388124
79Abnormal mitochondria in muscle tissue (HP:0008316)1.82365491
80Occipital encephalocele (HP:0002085)1.82235079
81Type 2 muscle fiber atrophy (HP:0003554)1.80521393
82Volvulus (HP:0002580)1.80457635
83Chromsome breakage (HP:0040012)1.76198522
84Hypoplasia of the pons (HP:0012110)1.75923026
85Postaxial hand polydactyly (HP:0001162)1.75403189
86Neoplasm of the adrenal gland (HP:0100631)1.75049313
87Increased muscle lipid content (HP:0009058)1.74854677
88Abnormality of the pons (HP:0007361)1.74763700
89Congenital stationary night blindness (HP:0007642)1.74392473
90Muscular hypotonia of the trunk (HP:0008936)1.73459527
91Abnormality of the preputium (HP:0100587)1.73084760
92Postnatal microcephaly (HP:0005484)1.71709421
93Broad foot (HP:0001769)1.71629769
94Abnormality of B cell number (HP:0010975)1.70661167
95Type II lissencephaly (HP:0007260)1.70431798
96Abnormality of serine family amino acid metabolism (HP:0010894)1.70323101
97Abnormality of glycine metabolism (HP:0010895)1.70323101
98Small intestinal stenosis (HP:0012848)1.66019807
99Duodenal stenosis (HP:0100867)1.66019807
100Cystic liver disease (HP:0006706)1.65538921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.44660174
2TRIM283.42259128
3ZAK2.85792934
4FRK2.85418253
5BMPR1B2.78210833
6PINK12.69625864
7VRK12.47745434
8CSNK1G32.46125453
9CSNK1A1L2.40553440
10MAP2K72.35047593
11VRK22.30863623
12WNK32.27657022
13CSNK1G12.16988154
14SRPK12.15308375
15TAOK32.14735965
16MARK32.14233465
17EIF2AK32.13490940
18BCKDK2.10044044
19SIK32.03405861
20CSNK1G22.02730294
21BCR2.00673923
22ERBB31.97522215
23NUAK11.77586694
24MAPK131.56265570
25BUB11.55144401
26MAP3K41.47887287
27TLK11.45842932
28PLK31.44683635
29RPS6KA41.34969043
30MST41.34374036
31DYRK21.13354472
32PLK21.09305319
33MARK11.05317375
34STK38L1.05170473
35CCNB11.03511678
36TSSK61.02503331
37PLK41.01409210
38ADRBK20.97671049
39EIF2AK10.94571513
40NLK0.89485588
41PLK10.89312700
42CDK80.88289230
43TXK0.87761214
44SCYL20.84131348
45TNIK0.81890904
46ATM0.81056599
47MAPKAPK30.80973381
48PBK0.78523858
49CASK0.78169010
50PRKCE0.77341498
51FES0.72647228
52ATR0.70880178
53BRD40.69129826
54MKNK20.68743243
55CDK30.68568109
56RPS6KA50.68269321
57DYRK30.63820743
58BRSK20.62234960
59FGFR20.61213849
60CLK10.60752050
61NEK10.59620048
62STK160.59550957
63EPHA30.58241845
64OBSCN0.55644988
65CAMKK20.54581454
66NEK20.54286101
67TIE10.52852197
68TGFBR10.52512571
69CSNK1D0.52277940
70MKNK10.52100184
71GRK10.49932781
72PAK30.49701897
73DAPK10.49416511
74MINK10.49134816
75AURKB0.47700433
76MAPKAPK50.43621651
77CDC70.42437473
78EEF2K0.41319718
79PRKAA10.40875856
80DYRK1A0.40068659
81PRKCQ0.39018334
82TRPM70.38558158
83CSNK1A10.37869966
84SIK20.37815657
85FLT30.37149258
86PRKCG0.37061992
87RPS6KB10.36419168
88CSNK2A10.31562254
89KDR0.31257684
90TTK0.31094926
91PAK60.30786027
92PASK0.30624697
93CHEK20.30393017
94PDK20.30013759
95CDK90.29237033
96KIT0.27755017
97PIM20.27551147
98CSNK2A20.26668455
99TEC0.25626844
100EGFR0.25534426

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.35076427
2RNA polymerase_Homo sapiens_hsa030202.99996595
3Basal transcription factors_Homo sapiens_hsa030222.91316018
4Proteasome_Homo sapiens_hsa030502.89812124
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.88006254
6Fanconi anemia pathway_Homo sapiens_hsa034602.77943079
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70869590
8Homologous recombination_Homo sapiens_hsa034402.69107229
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66918994
10Protein export_Homo sapiens_hsa030602.44703058
11Mismatch repair_Homo sapiens_hsa034302.36532772
12Propanoate metabolism_Homo sapiens_hsa006402.33666796
13Butanoate metabolism_Homo sapiens_hsa006502.30411060
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25808878
15Base excision repair_Homo sapiens_hsa034102.11957187
16RNA degradation_Homo sapiens_hsa030182.09104289
17Spliceosome_Homo sapiens_hsa030402.02409170
18Nucleotide excision repair_Homo sapiens_hsa034201.95519624
19DNA replication_Homo sapiens_hsa030301.88409483
20Phototransduction_Homo sapiens_hsa047441.74328674
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71729944
22RNA transport_Homo sapiens_hsa030131.70315528
23Selenocompound metabolism_Homo sapiens_hsa004501.70010063
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69242677
25Pyrimidine metabolism_Homo sapiens_hsa002401.66060510
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63857271
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61423927
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56969493
29One carbon pool by folate_Homo sapiens_hsa006701.55318653
30Oxidative phosphorylation_Homo sapiens_hsa001901.45384724
31Parkinsons disease_Homo sapiens_hsa050121.43714108
32Fatty acid elongation_Homo sapiens_hsa000621.43413771
33Peroxisome_Homo sapiens_hsa041461.33870107
34Purine metabolism_Homo sapiens_hsa002301.33590728
35Regulation of autophagy_Homo sapiens_hsa041401.31611415
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27107890
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22126524
38Nitrogen metabolism_Homo sapiens_hsa009101.20201223
39Olfactory transduction_Homo sapiens_hsa047401.07913365
40Circadian rhythm_Homo sapiens_hsa047101.06268717
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03987599
42Oocyte meiosis_Homo sapiens_hsa041141.03208419
43Primary immunodeficiency_Homo sapiens_hsa053400.99189488
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97385763
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96719702
46mRNA surveillance pathway_Homo sapiens_hsa030150.94446735
47Steroid biosynthesis_Homo sapiens_hsa001000.92383804
48Huntingtons disease_Homo sapiens_hsa050160.90918896
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87100729
50Cell cycle_Homo sapiens_hsa041100.85122237
51Fatty acid metabolism_Homo sapiens_hsa012120.84217333
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79152763
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78653205
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.77726148
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77165598
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76257368
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75886617
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75007932
59Alcoholism_Homo sapiens_hsa050340.73020409
60Metabolic pathways_Homo sapiens_hsa011000.68033574
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67874470
62Systemic lupus erythematosus_Homo sapiens_hsa053220.65420529
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64959143
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64469717
65Nicotine addiction_Homo sapiens_hsa050330.64232784
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63645365
67Alzheimers disease_Homo sapiens_hsa050100.61872471
68Glutathione metabolism_Homo sapiens_hsa004800.61186527
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61144978
70Pyruvate metabolism_Homo sapiens_hsa006200.58923874
71p53 signaling pathway_Homo sapiens_hsa041150.56334904
72Carbon metabolism_Homo sapiens_hsa012000.52296478
73beta-Alanine metabolism_Homo sapiens_hsa004100.52225527
74N-Glycan biosynthesis_Homo sapiens_hsa005100.48452151
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47368598
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47050350
77Linoleic acid metabolism_Homo sapiens_hsa005910.46806404
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46057936
79Taste transduction_Homo sapiens_hsa047420.43426250
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43395945
81GABAergic synapse_Homo sapiens_hsa047270.41098672
82Collecting duct acid secretion_Homo sapiens_hsa049660.40719293
83Folate biosynthesis_Homo sapiens_hsa007900.37257045
84Ether lipid metabolism_Homo sapiens_hsa005650.37229751
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37038129
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36571687
87Fatty acid biosynthesis_Homo sapiens_hsa000610.33230619
88Epstein-Barr virus infection_Homo sapiens_hsa051690.31061187
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.27158243
90Fructose and mannose metabolism_Homo sapiens_hsa000510.26587873
91Herpes simplex infection_Homo sapiens_hsa051680.25270964
92Biosynthesis of amino acids_Homo sapiens_hsa012300.24354788
93Lysine degradation_Homo sapiens_hsa003100.23823563
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.23788180
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23305331
96Sphingolipid metabolism_Homo sapiens_hsa006000.21592328
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20991334
98Type I diabetes mellitus_Homo sapiens_hsa049400.20248619
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17310395
100Arachidonic acid metabolism_Homo sapiens_hsa005900.16109217

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