MRPS22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.38979674
2proteasome assembly (GO:0043248)4.67185124
3purine nucleobase biosynthetic process (GO:0009113)4.47200660
4DNA strand elongation involved in DNA replication (GO:0006271)4.35896737
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.35286834
6nucleobase biosynthetic process (GO:0046112)4.34049023
7maturation of SSU-rRNA (GO:0030490)4.31279388
8telomere maintenance via semi-conservative replication (GO:0032201)4.27410770
9DNA replication initiation (GO:0006270)4.19100527
10ribosome assembly (GO:0042255)4.18824049
11DNA strand elongation (GO:0022616)4.13292616
12respiratory electron transport chain (GO:0022904)4.10523566
13DNA replication checkpoint (GO:0000076)4.08888991
14mitotic metaphase plate congression (GO:0007080)4.01078848
15electron transport chain (GO:0022900)4.00712906
16ribosomal small subunit assembly (GO:0000028)4.00362576
17formation of translation preinitiation complex (GO:0001731)3.98796008
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.95596779
19NADH dehydrogenase complex assembly (GO:0010257)3.95596779
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95596779
21CENP-A containing nucleosome assembly (GO:0034080)3.94361228
22ribosomal large subunit biogenesis (GO:0042273)3.93629928
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93439343
24chaperone-mediated protein transport (GO:0072321)3.93240492
25protein complex biogenesis (GO:0070271)3.91405646
26ribosome biogenesis (GO:0042254)3.91367766
27mitochondrial respiratory chain complex assembly (GO:0033108)3.91181398
28protein deneddylation (GO:0000338)3.89504635
29chromatin remodeling at centromere (GO:0031055)3.89024732
30regulation of mitochondrial translation (GO:0070129)3.82914855
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82071293
32telomere maintenance via recombination (GO:0000722)3.81303394
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80768673
34pseudouridine synthesis (GO:0001522)3.80483364
35ribonucleoprotein complex biogenesis (GO:0022613)3.79565299
36cullin deneddylation (GO:0010388)3.79484161
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.79452075
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78490547
39spliceosomal snRNP assembly (GO:0000387)3.77061866
40oxidative phosphorylation (GO:0006119)3.64398325
41rRNA modification (GO:0000154)3.59297720
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.58147832
43negative regulation of ligase activity (GO:0051352)3.58147832
44mitotic recombination (GO:0006312)3.55106036
45respiratory chain complex IV assembly (GO:0008535)3.53972383
46ribosomal small subunit biogenesis (GO:0042274)3.53493752
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.51458349
48termination of RNA polymerase III transcription (GO:0006386)3.51458349
49rRNA processing (GO:0006364)3.49621770
50DNA unwinding involved in DNA replication (GO:0006268)3.48409641
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47696173
52metaphase plate congression (GO:0051310)3.44595657
53DNA replication-independent nucleosome organization (GO:0034724)3.43564039
54DNA replication-independent nucleosome assembly (GO:0006336)3.43564039
55regulation of cellular amino acid metabolic process (GO:0006521)3.43278703
56folic acid-containing compound biosynthetic process (GO:0009396)3.41052296
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.40926080
58folic acid metabolic process (GO:0046655)3.40646868
59protein localization to kinetochore (GO:0034501)3.40456134
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38794475
61ATP synthesis coupled proton transport (GO:0015986)3.38794475
62rRNA metabolic process (GO:0016072)3.37262892
63telomere maintenance via telomere lengthening (GO:0010833)3.36631057
64translational termination (GO:0006415)3.33780866
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33630123
66histone exchange (GO:0043486)3.32422519
67spliceosomal complex assembly (GO:0000245)3.32296645
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30561633
69kinetochore organization (GO:0051383)3.30237821
70IMP biosynthetic process (GO:0006188)3.29431971
71viral transcription (GO:0019083)3.29394391
727-methylguanosine mRNA capping (GO:0006370)3.28543584
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.27572589
74establishment of integrated proviral latency (GO:0075713)3.26791633
75cellular component biogenesis (GO:0044085)3.26742268
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26123487
77translational initiation (GO:0006413)3.25260778
78protein neddylation (GO:0045116)3.23624459
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23172865
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23172865
81peptidyl-histidine modification (GO:0018202)3.23117505
82transcription-coupled nucleotide-excision repair (GO:0006283)3.22877070
837-methylguanosine RNA capping (GO:0009452)3.22660689
84RNA capping (GO:0036260)3.22660689
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21242557
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21242557
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21242557
88protein localization to mitochondrion (GO:0070585)3.20323353
89positive regulation of ligase activity (GO:0051351)3.19910955
90translational elongation (GO:0006414)3.19776932
91kinetochore assembly (GO:0051382)3.19249630
92DNA replication-dependent nucleosome assembly (GO:0006335)3.19225118
93DNA replication-dependent nucleosome organization (GO:0034723)3.19225118
94transcription elongation from RNA polymerase I promoter (GO:0006362)3.17824795
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17616091
96signal transduction involved in DNA damage checkpoint (GO:0072422)3.17118475
97signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17118475
98G1/S transition of mitotic cell cycle (GO:0000082)3.15334412
99cell cycle G1/S phase transition (GO:0044843)3.15334412
100cotranslational protein targeting to membrane (GO:0006613)3.15170506
101translation (GO:0006412)3.15134128
102mitotic nuclear envelope disassembly (GO:0007077)3.13372102
103amino acid activation (GO:0043038)3.13249116
104tRNA aminoacylation (GO:0043039)3.13249116
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12000179
106cytochrome complex assembly (GO:0017004)3.11529848
107signal transduction involved in cell cycle checkpoint (GO:0072395)3.11334321
108tRNA aminoacylation for protein translation (GO:0006418)3.11303013
109mitochondrial RNA metabolic process (GO:0000959)3.09409732
110protein targeting to ER (GO:0045047)3.09115651
111establishment of chromosome localization (GO:0051303)3.08737743
112transcription from mitochondrial promoter (GO:0006390)3.07333671
113rRNA methylation (GO:0031167)3.07231415
114attachment of spindle microtubules to kinetochore (GO:0008608)3.07028427
115termination of RNA polymerase I transcription (GO:0006363)3.02908893
116regulation of ligase activity (GO:0051340)3.02877529
117maturation of 5.8S rRNA (GO:0000460)3.02809398
118establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02553624
119protein targeting to mitochondrion (GO:0006626)3.01328055
120regulation of ubiquitin-protein transferase activity (GO:0051438)2.99524987
121protein localization to chromosome, centromeric region (GO:0071459)2.99062728
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98662683
123establishment of protein localization to mitochondrion (GO:0072655)2.98178333
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.96991795
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96991795
126negative regulation of sister chromatid segregation (GO:0033046)2.96991795
127DNA catabolic process, exonucleolytic (GO:0000738)2.95368562
128protein localization to endoplasmic reticulum (GO:0070972)2.95301327
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94176635
130water-soluble vitamin biosynthetic process (GO:0042364)2.90866953
131IMP metabolic process (GO:0046040)2.89358230
132pteridine-containing compound biosynthetic process (GO:0042559)2.88769348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.73450836
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54626386
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21853436
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05065447
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.74061543
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63654824
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.51972273
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.33604060
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30333185
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.26479365
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13436723
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.94005044
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93160715
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83273180
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78084108
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76271711
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61373010
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60305341
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57971562
20VDR_23849224_ChIP-Seq_CD4+_Human2.55748949
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53129849
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43615866
23XRN2_22483619_ChIP-Seq_HELA_Human2.42241661
24DCP1A_22483619_ChIP-Seq_HELA_Human2.36370974
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33006250
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30288725
27FOXP3_21729870_ChIP-Seq_TREG_Human2.28305275
28GABP_19822575_ChIP-Seq_HepG2_Human2.23173330
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16879000
30AR_21909140_ChIP-Seq_LNCAP_Human2.15900160
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15015158
32* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13177457
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08026935
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.01637607
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94846043
36TTF2_22483619_ChIP-Seq_HELA_Human1.92383405
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.90131727
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89866092
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87690091
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84884653
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.84818236
42* ELK1_19687146_ChIP-ChIP_HELA_Human1.79388614
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75196526
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74979634
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71548748
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71231914
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71152271
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68381088
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68323776
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62553201
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56408764
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52864805
53CIITA_25753668_ChIP-Seq_RAJI_Human1.47394841
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43452876
55KDM5A_27292631_Chip-Seq_BREAST_Human1.42402420
56* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39905135
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39345658
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37877266
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37295303
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36423820
61VDR_22108803_ChIP-Seq_LS180_Human1.32983855
62EWS_26573619_Chip-Seq_HEK293_Human1.31074057
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29174344
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25177336
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23637879
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21764607
67MYC_18940864_ChIP-ChIP_HL60_Human1.21033808
68FUS_26573619_Chip-Seq_HEK293_Human1.19220540
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17277193
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15884574
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15090458
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14758871
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12988632
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.08077349
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07476786
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06295552
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06266545
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05531896
79* ELK1_22589737_ChIP-Seq_MCF10A_Human1.04930486
80ZNF274_21170338_ChIP-Seq_K562_Hela1.04635018
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.02310011
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00967871
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99345326
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98354379
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97631083
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97086652
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95589115
88TFEB_21752829_ChIP-Seq_HELA_Human0.94537152
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88639627
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88202686
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87976654
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85933577
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.82385014
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80590898
95IGF1R_20145208_ChIP-Seq_DFB_Human0.80421704
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79468839
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78919719
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76809568
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76721674
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76198249
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75785835
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.75297379
103ELF5_23300383_ChIP-Seq_T47D_Human0.74080956
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73984252
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73178054
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72715432
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.72511808
108IRF1_19129219_ChIP-ChIP_H3396_Human0.72005419
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71670350
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70910668
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70869104
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70430826
113ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.70262266
114SPI1_23547873_ChIP-Seq_NB4_Human0.70010565
115TP53_22573176_ChIP-Seq_HFKS_Human0.69100390
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.68727499
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.67259229
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.65064785
119EGR1_23403033_ChIP-Seq_LIVER_Mouse0.64272386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.86715382
2MP0010094_abnormal_chromosome_stability4.67328759
3MP0004957_abnormal_blastocyst_morpholog4.60105341
4MP0003111_abnormal_nucleus_morphology4.38720841
5MP0008057_abnormal_DNA_replication4.11908363
6MP0003077_abnormal_cell_cycle4.03976039
7MP0008058_abnormal_DNA_repair3.88138486
8MP0003806_abnormal_nucleotide_metabolis3.19064007
9MP0003718_maternal_effect3.05344424
10MP0002837_dystrophic_cardiac_calcinosis2.90507983
11MP0008932_abnormal_embryonic_tissue2.85620732
12MP0003123_paternal_imprinting2.64583764
13MP0008007_abnormal_cellular_replicative2.57654960
14MP0006036_abnormal_mitochondrial_physio2.36010791
15MP0001730_embryonic_growth_arrest2.26344107
16MP0003786_premature_aging2.26000965
17MP0003186_abnormal_redox_activity2.15410525
18MP0009697_abnormal_copulation2.15168143
19MP0006035_abnormal_mitochondrial_morpho2.06438661
20MP0008877_abnormal_DNA_methylation2.02393517
21MP0000350_abnormal_cell_proliferation1.82846919
22MP0004147_increased_porphyrin_level1.81792542
23MP0000372_irregular_coat_pigmentation1.78053952
24MP0002396_abnormal_hematopoietic_system1.74533891
25MP0001764_abnormal_homeostasis1.69971783
26MP0002102_abnormal_ear_morphology1.69206993
27MP0000749_muscle_degeneration1.68451273
28MP0004145_abnormal_muscle_electrophysio1.63631661
29MP0003941_abnormal_skin_development1.58179816
30MP0006072_abnormal_retinal_apoptosis1.53271577
31MP0002139_abnormal_hepatobiliary_system1.50732797
32MP0003221_abnormal_cardiomyocyte_apopto1.50048877
33MP0002210_abnormal_sex_determination1.49493484
34MP0001697_abnormal_embryo_size1.48892373
35MP0003656_abnormal_erythrocyte_physiolo1.48732173
36MP0000313_abnormal_cell_death1.48000816
37MP0005380_embryogenesis_phenotype1.47563352
38MP0001672_abnormal_embryogenesis/_devel1.47563352
39MP0002080_prenatal_lethality1.44956707
40MP0001529_abnormal_vocalization1.44653851
41MP0000490_abnormal_crypts_of1.44241965
42MP0000358_abnormal_cell_content/1.39544009
43MP0008995_early_reproductive_senescence1.37343095
44MP0005408_hypopigmentation1.37287139
45MP0001929_abnormal_gametogenesis1.35826302
46MP0005330_cardiomyopathy1.33089259
47MP0001145_abnormal_male_reproductive1.30047000
48MP0005360_urolithiasis1.29728846
49MP0003984_embryonic_growth_retardation1.29349255
50MP0003195_calcinosis1.27583735
51MP0010307_abnormal_tumor_latency1.26452640
52MP0009379_abnormal_foot_pigmentation1.26285508
53MP0002088_abnormal_embryonic_growth/wei1.25604687
54MP0003646_muscle_fatigue1.23440891
55MP0003567_abnormal_fetal_cardiomyocyte1.22186787
56MP0003315_abnormal_perineum_morphology1.20060937
57MP0002019_abnormal_tumor_incidence1.18989535
58MP0000653_abnormal_sex_gland1.18954042
59MP0005365_abnormal_bile_salt1.16370996
60MP0003136_yellow_coat_color1.15427599
61MP0000647_abnormal_sebaceous_gland1.12559720
62MP0003950_abnormal_plasma_membrane1.12082286
63MP0002234_abnormal_pharynx_morphology1.11942186
64MP0002160_abnormal_reproductive_system1.08744731
65MP0009333_abnormal_splenocyte_physiolog1.07891333
66MP0005266_abnormal_metabolism1.02907065
67MP0005085_abnormal_gallbladder_physiolo1.02461501
68MP0002085_abnormal_embryonic_tissue1.01634768
69MP0002132_abnormal_respiratory_system1.01035876
70MP0001119_abnormal_female_reproductive0.99628195
71MP0003137_abnormal_impulse_conducting0.96820077
72MP0008789_abnormal_olfactory_epithelium0.96637996
73MP0005389_reproductive_system_phenotype0.95728809
74MP0003937_abnormal_limbs/digits/tail_de0.95664779
75MP0008260_abnormal_autophagy0.95616273
76MP0005253_abnormal_eye_physiology0.93628484
77MP0001661_extended_life_span0.93549984
78MP0001853_heart_inflammation0.91783015
79MP0002086_abnormal_extraembryonic_tissu0.90576095
80MP0003121_genomic_imprinting0.86178367
81MP0008875_abnormal_xenobiotic_pharmacok0.84979850
82MP0005075_abnormal_melanosome_morpholog0.84677365
83MP0005332_abnormal_amino_acid0.83388844
84MP0002084_abnormal_developmental_patter0.83245149
85MP0004808_abnormal_hematopoietic_stem0.83086360
86MP0004233_abnormal_muscle_weight0.82420821
87MP0004036_abnormal_muscle_relaxation0.82413189
88MP0006292_abnormal_olfactory_placode0.82349211
89MP0005636_abnormal_mineral_homeostasis0.81853613
90MP0005084_abnormal_gallbladder_morpholo0.81789917
91MP0001984_abnormal_olfaction0.80688144
92MP0005395_other_phenotype0.79695087
93MP0003011_delayed_dark_adaptation0.79537651
94MP0003698_abnormal_male_reproductive0.78054856
95MP0001545_abnormal_hematopoietic_system0.77714470
96MP0005397_hematopoietic_system_phenotyp0.77714470
97MP0009053_abnormal_anal_canal0.77694999
98MP0005384_cellular_phenotype0.77267893
99MP0005187_abnormal_penis_morphology0.75579896
100MP0002163_abnormal_gland_morphology0.75340687
101MP0002161_abnormal_fertility/fecundity0.74687245
102MP0010030_abnormal_orbit_morphology0.73221547
103MP0005379_endocrine/exocrine_gland_phen0.73073652
104MP0003699_abnormal_female_reproductive0.72657725
105MP0009672_abnormal_birth_weight0.72566539
106MP0008775_abnormal_heart_ventricle0.72308001
107MP0002090_abnormal_vision0.71869244
108MP0005319_abnormal_enzyme/_coenzyme0.71832072
109MP0004197_abnormal_fetal_growth/weight/0.70697757
110MP0004215_abnormal_myocardial_fiber0.70075500
111MP0002638_abnormal_pupillary_reflex0.70063249
112MP0002938_white_spotting0.69828921
113MP0000631_abnormal_neuroendocrine_gland0.69356074
114MP0001881_abnormal_mammary_gland0.68915463
115MP0000750_abnormal_muscle_regeneration0.68426602
116MP0005376_homeostasis/metabolism_phenot0.68301703
117MP0000689_abnormal_spleen_morphology0.67338867
118MP0004084_abnormal_cardiac_muscle0.66568956
119MP0001727_abnormal_embryo_implantation0.66044607
120MP0003763_abnormal_thymus_physiology0.66026237
121MP0010352_gastrointestinal_tract_polyps0.64584553
122MP0000598_abnormal_liver_morphology0.64484267
123MP0002722_abnormal_immune_system0.64387138
124MP0000703_abnormal_thymus_morphology0.64281262
125MP0001919_abnormal_reproductive_system0.63299551
126MP0003890_abnormal_embryonic-extraembry0.62931079
127MP0001286_abnormal_eye_development0.62505400
128MP0009840_abnormal_foam_cell0.61921160
129MP0005646_abnormal_pituitary_gland0.61013982
130MP0004142_abnormal_muscle_tone0.59289390
131MP0002269_muscular_atrophy0.58839404
132MP0002233_abnormal_nose_morphology0.58346640
133MP0002095_abnormal_skin_pigmentation0.57459218
134MP0000537_abnormal_urethra_morphology0.56619814
135MP0001293_anophthalmia0.56551658
136MP0005621_abnormal_cell_physiology0.55934911

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.98766727
2Abnormality of cells of the erythroid lineage (HP:0012130)4.07557233
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.00108731
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.00108731
5Abnormal number of erythroid precursors (HP:0012131)3.95668123
6Oral leukoplakia (HP:0002745)3.91508319
7Increased hepatocellular lipid droplets (HP:0006565)3.80475906
8Abnormality of alanine metabolism (HP:0010916)3.76894290
9Hyperalaninemia (HP:0003348)3.76894290
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.76894290
11Hepatocellular necrosis (HP:0001404)3.72639696
12Increased CSF lactate (HP:0002490)3.72037742
13* Increased serum lactate (HP:0002151)3.64501160
14Lipid accumulation in hepatocytes (HP:0006561)3.62073434
15Hepatic necrosis (HP:0002605)3.60658945
16Mitochondrial inheritance (HP:0001427)3.58144289
17Acute necrotizing encephalopathy (HP:0006965)3.56181100
18Breast hypoplasia (HP:0003187)3.53209378
19Abnormal mitochondria in muscle tissue (HP:0008316)3.48190076
20Reticulocytopenia (HP:0001896)3.48175088
21Abnormality of glycolysis (HP:0004366)3.40474123
22Increased serum pyruvate (HP:0003542)3.40474123
23Cerebral hypomyelination (HP:0006808)3.31158010
24Acute encephalopathy (HP:0006846)3.23811417
253-Methylglutaconic aciduria (HP:0003535)3.15960706
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07736666
27Microvesicular hepatic steatosis (HP:0001414)3.06076732
28Microretrognathia (HP:0000308)3.04189044
29Lactic acidosis (HP:0003128)3.03820891
30Macrocytic anemia (HP:0001972)3.00919289
31Rough bone trabeculation (HP:0100670)2.94782190
32Hyperglycinemia (HP:0002154)2.90388090
33Aplastic anemia (HP:0001915)2.87819355
34Increased intramyocellular lipid droplets (HP:0012240)2.81134970
35Colon cancer (HP:0003003)2.80278606
36Abnormality of methionine metabolism (HP:0010901)2.78109745
37Carpal bone hypoplasia (HP:0001498)2.76592002
38CNS demyelination (HP:0007305)2.74475450
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74340503
40Progressive macrocephaly (HP:0004481)2.72810523
41Multiple enchondromatosis (HP:0005701)2.71730556
42Cerebral edema (HP:0002181)2.71321113
43Patellar aplasia (HP:0006443)2.69321248
44Selective tooth agenesis (HP:0001592)2.68538586
45Abnormality of the anterior horn cell (HP:0006802)2.65560984
46Degeneration of anterior horn cells (HP:0002398)2.65560984
47Aplasia/Hypoplasia of the patella (HP:0006498)2.61843422
48Abnormality of serum amino acid levels (HP:0003112)2.60100151
49Generalized aminoaciduria (HP:0002909)2.59029227
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.55373076
51Pallor (HP:0000980)2.54613120
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51749971
53Abnormal protein N-linked glycosylation (HP:0012347)2.51749971
54Abnormal protein glycosylation (HP:0012346)2.51749971
55Abnormal glycosylation (HP:0012345)2.51749971
56Increased muscle lipid content (HP:0009058)2.50072534
57Megaloblastic anemia (HP:0001889)2.47353948
58Leukodystrophy (HP:0002415)2.44618981
59Exercise intolerance (HP:0003546)2.44418803
60Nausea (HP:0002018)2.43827537
61Respiratory difficulties (HP:0002880)2.40478501
62Premature ovarian failure (HP:0008209)2.40172286
63Exertional dyspnea (HP:0002875)2.39281781
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36502138
65Secondary amenorrhea (HP:0000869)2.34454014
66Abnormal spermatogenesis (HP:0008669)2.34425018
67Abnormality of the preputium (HP:0100587)2.32007216
68Optic disc pallor (HP:0000543)2.31964589
69Renal Fanconi syndrome (HP:0001994)2.31641235
70Pancytopenia (HP:0001876)2.30545880
71Methylmalonic acidemia (HP:0002912)2.27522478
72Hypoglycemic coma (HP:0001325)2.26297272
73Hypobetalipoproteinemia (HP:0003563)2.26020248
74Impulsivity (HP:0100710)2.24304891
75Lethargy (HP:0001254)2.23151471
76Premature graying of hair (HP:0002216)2.22532754
77Respiratory failure (HP:0002878)2.22383051
78Abnormality of pyrimidine metabolism (HP:0004353)2.20571949
79Glycosuria (HP:0003076)2.18910357
80Abnormality of urine glucose concentration (HP:0011016)2.18910357
81Palpitations (HP:0001962)2.18574276
82CNS hypomyelination (HP:0003429)2.16589032
83Emotional lability (HP:0000712)2.16486549
84Type I transferrin isoform profile (HP:0003642)2.16305179
85Chromsome breakage (HP:0040012)2.16187855
86Abnormality of chromosome stability (HP:0003220)2.15686272
87Horseshoe kidney (HP:0000085)2.14854904
88Absent thumb (HP:0009777)2.14245279
89Renal cortical cysts (HP:0000803)2.13966566
90Cellular immunodeficiency (HP:0005374)2.13764305
91Methylmalonic aciduria (HP:0012120)2.11051592
92Abnormal trabecular bone morphology (HP:0100671)2.09207964
93Abnormality of the labia minora (HP:0012880)2.07455581
94Exercise-induced muscle cramps (HP:0003710)2.05992135
95Abnormality of serine family amino acid metabolism (HP:0010894)2.05990775
96Abnormality of glycine metabolism (HP:0010895)2.05990775
97Hyperglycinuria (HP:0003108)2.05847394
98Meckel diverticulum (HP:0002245)2.04114735
99Unsteady gait (HP:0002317)2.03818338
100Amniotic constriction ring (HP:0009775)2.01743860
101Abnormality of placental membranes (HP:0011409)2.01743860
102Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01700975
10311 pairs of ribs (HP:0000878)2.00766400
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.98278703
105Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97976051
106Dicarboxylic aciduria (HP:0003215)1.97976051
107Trismus (HP:0000211)1.96897131
108Abnormality of renal resorption (HP:0011038)1.94723814
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94354426
110Medulloblastoma (HP:0002885)1.93904783
111Progressive muscle weakness (HP:0003323)1.93301874
112Gliosis (HP:0002171)1.93260966
113Bone marrow hypocellularity (HP:0005528)1.92954183
114Abnormality of the ileum (HP:0001549)1.90641081
115Ragged-red muscle fibers (HP:0003200)1.89509128
116Neoplasm of the pancreas (HP:0002894)1.88379584
117Poikiloderma (HP:0001029)1.87883493
118Entropion (HP:0000621)1.86176575
119Reduced antithrombin III activity (HP:0001976)1.84108931
120Abnormality of midbrain morphology (HP:0002418)1.82708534
121Molar tooth sign on MRI (HP:0002419)1.82708534
122Sloping forehead (HP:0000340)1.81800127
123Pancreatic cysts (HP:0001737)1.81401658
124Rhabdomyosarcoma (HP:0002859)1.81210540
125Abnormal lung lobation (HP:0002101)1.79807108
126Type 2 muscle fiber atrophy (HP:0003554)1.78647238
127X-linked dominant inheritance (HP:0001423)1.74738660
128Neuroendocrine neoplasm (HP:0100634)1.73878903
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.71746670
130Abnormality of the pons (HP:0007361)1.70133665
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69297559
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65728196
133Duodenal stenosis (HP:0100867)1.65052231
134Small intestinal stenosis (HP:0012848)1.65052231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.00759232
2WEE14.39983647
3EIF2AK14.05967449
4STK163.68359122
5CDC73.39720517
6MST43.18126714
7NME22.84055941
8ACVR1B2.79855722
9EIF2AK32.66308996
10PLK42.57537393
11SRPK12.51199055
12VRK22.46911202
13BRSK22.45533071
14NEK12.37120692
15VRK12.25943930
16NEK22.16548532
17TLK12.10457343
18TTK2.07428930
19MAP4K22.01089659
20TSSK62.00880604
21PLK11.99193973
22BRSK11.90599277
23BCKDK1.74937745
24TRIM281.73630298
25TESK21.69260497
26AURKB1.56231041
27PDK31.48206941
28PDK41.48206941
29PLK31.47570733
30AURKA1.44658695
31DYRK31.39996255
32CCNB11.37828038
33ATR1.37193562
34ERBB31.34871455
35NME11.27978980
36WNK31.27159164
37CHEK21.22558869
38CDK71.21169772
39SCYL21.21045860
40ZAK1.20264830
41MKNK11.17599158
42BRAF1.17585293
43CDK81.14829265
44MKNK21.03677857
45TNIK0.96022079
46RPS6KA40.95737070
47EIF2AK20.93663769
48KDR0.92102558
49CHEK10.90359953
50PASK0.89766825
51RPS6KB20.86444898
52PIM20.85621692
53MAP3K80.81411795
54CDK40.81127425
55BCR0.79795673
56CSNK2A10.79511318
57FRK0.78544454
58CSNK2A20.77201827
59PAK40.77002264
60PBK0.73089286
61MAP3K40.71686625
62ATM0.65899507
63TGFBR10.65094404
64PINK10.64485903
65PHKG10.64375049
66PHKG20.64375049
67PDK20.62618437
68WNK40.62558021
69TAF10.62336080
70MAPKAPK30.62186349
71STK40.61813321
72CLK10.61812358
73CDK20.61199552
74TAOK20.60918291
75PAK10.58565464
76ABL20.58537595
77PLK20.57755812
78MAP3K120.57387798
79CDK30.57014650
80GRK10.55578566
81MAP2K70.55381311
82STK38L0.54943883
83TESK10.54823135
84DYRK20.54474035
85MELK0.54439438
86IRAK30.54334113
87ERBB40.52808059
88STK30.52689929
89STK390.52348004
90NLK0.51066378
91MAP3K110.50266130
92CSNK1A1L0.50038391
93MST1R0.47521703
94CSNK1G20.47480628
95EPHA20.46817825
96CDK10.46203268
97CSNK1G30.44478672
98MAP3K50.43955089
99RPS6KA50.43322789
100ALK0.42948114
101NUAK10.42736719
102ILK0.42315444
103LIMK10.40685903
104MUSK0.40164000
105PRKCI0.39524275
106NEK90.38331606
107OBSCN0.37962264
108FGFR10.37444220
109DAPK10.37019538
110TEC0.36860516
111OXSR10.36759850
112BMPR1B0.36448648
113CDK190.35434166
114ADRBK20.35323382
115DAPK30.35090425
116PIM10.35082626
117STK100.33603202
118PNCK0.32943222
119LRRK20.32220028
120AKT20.32003476
121ARAF0.30192169
122CSNK1E0.29204030
123BMPR20.28957212
124MAPKAPK50.28671943
125AKT30.27969675
126MYLK0.27087058
127MAP3K60.27052581
128CDK120.25930334
129IRAK40.25119536
130CSNK1G10.24702013
131MAP2K30.20189657
132STK240.19979285
133PRKDC0.19611249

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22539254
2Proteasome_Homo sapiens_hsa030504.11712136
3Ribosome_Homo sapiens_hsa030103.49837478
4RNA polymerase_Homo sapiens_hsa030203.49780532
5Mismatch repair_Homo sapiens_hsa034303.47219565
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.39585121
7Spliceosome_Homo sapiens_hsa030402.81368103
8Pyrimidine metabolism_Homo sapiens_hsa002402.70016803
9RNA transport_Homo sapiens_hsa030132.68236050
10Homologous recombination_Homo sapiens_hsa034402.60176769
11Base excision repair_Homo sapiens_hsa034102.59805343
12Nucleotide excision repair_Homo sapiens_hsa034202.59750499
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28185642
14One carbon pool by folate_Homo sapiens_hsa006702.20996573
15Cell cycle_Homo sapiens_hsa041102.06307365
16Basal transcription factors_Homo sapiens_hsa030221.92461352
17Parkinsons disease_Homo sapiens_hsa050121.89521279
18Oxidative phosphorylation_Homo sapiens_hsa001901.88169083
19RNA degradation_Homo sapiens_hsa030181.74521186
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69589182
21Non-homologous end-joining_Homo sapiens_hsa034501.68188832
22Fanconi anemia pathway_Homo sapiens_hsa034601.66069868
23Huntingtons disease_Homo sapiens_hsa050161.53817773
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.52582381
25Folate biosynthesis_Homo sapiens_hsa007901.51251059
26Purine metabolism_Homo sapiens_hsa002301.51245279
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41487319
28Sulfur relay system_Homo sapiens_hsa041221.39799233
29Vitamin B6 metabolism_Homo sapiens_hsa007501.39048966
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33223050
31Biosynthesis of amino acids_Homo sapiens_hsa012301.31960586
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31276603
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29130704
34Protein export_Homo sapiens_hsa030601.29098843
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.26850105
36Pentose phosphate pathway_Homo sapiens_hsa000301.24528331
37Carbon metabolism_Homo sapiens_hsa012001.23365435
38Sulfur metabolism_Homo sapiens_hsa009201.21315923
39Fatty acid elongation_Homo sapiens_hsa000621.15235059
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12678707
41Selenocompound metabolism_Homo sapiens_hsa004501.11165432
42mRNA surveillance pathway_Homo sapiens_hsa030151.05870733
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03995113
44p53 signaling pathway_Homo sapiens_hsa041151.03719537
45Systemic lupus erythematosus_Homo sapiens_hsa053221.02951494
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00763696
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99074688
48Alzheimers disease_Homo sapiens_hsa050100.97321743
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95848219
50Pyruvate metabolism_Homo sapiens_hsa006200.90878180
51Steroid biosynthesis_Homo sapiens_hsa001000.88788455
52Glutathione metabolism_Homo sapiens_hsa004800.85194455
53Epstein-Barr virus infection_Homo sapiens_hsa051690.84693515
54Propanoate metabolism_Homo sapiens_hsa006400.81802884
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79794913
56Fructose and mannose metabolism_Homo sapiens_hsa000510.78812546
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.76892370
58Oocyte meiosis_Homo sapiens_hsa041140.73296370
59Metabolic pathways_Homo sapiens_hsa011000.69098943
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65348801
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64352999
62Regulation of autophagy_Homo sapiens_hsa041400.58284485
63Peroxisome_Homo sapiens_hsa041460.55685627
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55628963
65Fatty acid degradation_Homo sapiens_hsa000710.50449196
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49327506
67Cardiac muscle contraction_Homo sapiens_hsa042600.48477895
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47685237
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45300579
70Herpes simplex infection_Homo sapiens_hsa051680.44250705
71N-Glycan biosynthesis_Homo sapiens_hsa005100.43002029
72Galactose metabolism_Homo sapiens_hsa000520.42528495
73Arginine and proline metabolism_Homo sapiens_hsa003300.42054861
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.40704608
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39759575
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36807593
77Collecting duct acid secretion_Homo sapiens_hsa049660.36589447
78Caffeine metabolism_Homo sapiens_hsa002320.36142619
79Nitrogen metabolism_Homo sapiens_hsa009100.35851929
80Viral carcinogenesis_Homo sapiens_hsa052030.35383226
81Butanoate metabolism_Homo sapiens_hsa006500.33953573
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.33234371
83Antigen processing and presentation_Homo sapiens_hsa046120.33201669
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31690221
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30869938
86beta-Alanine metabolism_Homo sapiens_hsa004100.30626675
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24944903
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23944122
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21928949
90Legionellosis_Homo sapiens_hsa051340.21593511
91Alcoholism_Homo sapiens_hsa050340.21407994
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20080733
93Tyrosine metabolism_Homo sapiens_hsa003500.19976185
94Thyroid cancer_Homo sapiens_hsa052160.19446390
95Vitamin digestion and absorption_Homo sapiens_hsa049770.18851757
96Renin-angiotensin system_Homo sapiens_hsa046140.17950968
97Chemical carcinogenesis_Homo sapiens_hsa052040.17800749
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16679966
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16259248
100Retinol metabolism_Homo sapiens_hsa008300.14211938
101Fat digestion and absorption_Homo sapiens_hsa049750.13808065
102Tryptophan metabolism_Homo sapiens_hsa003800.13469342
103HTLV-I infection_Homo sapiens_hsa051660.12603137
104Phototransduction_Homo sapiens_hsa047440.12556432
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12278435
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11193807
107Arginine biosynthesis_Homo sapiens_hsa002200.10932278
108Fatty acid metabolism_Homo sapiens_hsa012120.10479129
109Linoleic acid metabolism_Homo sapiens_hsa005910.09977884
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.09558060
111Phenylalanine metabolism_Homo sapiens_hsa003600.08893452
112Circadian rhythm_Homo sapiens_hsa047100.07193751

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