MRPL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is a nuclear gene encoding a protein component of the 39S subunit of the mitochondrial ribosome. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.66283925
2chaperone-mediated protein transport (GO:0072321)4.20650779
3spliceosomal snRNP assembly (GO:0000387)4.18249893
4maturation of 5.8S rRNA (GO:0000460)4.08079142
5ribosomal small subunit assembly (GO:0000028)4.06580442
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.06333392
7establishment of integrated proviral latency (GO:0075713)3.93127959
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87522645
9purine nucleobase biosynthetic process (GO:0009113)3.86008705
10formation of translation preinitiation complex (GO:0001731)3.84639334
11nucleobase biosynthetic process (GO:0046112)3.82979856
12maturation of SSU-rRNA (GO:0030490)3.81814087
13protein targeting to mitochondrion (GO:0006626)3.80458388
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74183899
15signal transduction involved in DNA damage checkpoint (GO:0072422)3.62173472
16ribosomal small subunit biogenesis (GO:0042274)3.60541495
17signal transduction involved in cell cycle checkpoint (GO:0072395)3.57290331
18establishment of protein localization to mitochondrion (GO:0072655)3.54959025
19positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.51972654
20oxidative phosphorylation (GO:0006119)3.50864086
21viral transcription (GO:0019083)3.49632514
22ATP synthesis coupled proton transport (GO:0015986)3.49544162
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49544162
24serine family amino acid biosynthetic process (GO:0009070)3.48160834
25L-serine metabolic process (GO:0006563)3.46818924
26glycine metabolic process (GO:0006544)3.44140102
27protein localization to mitochondrion (GO:0070585)3.43459528
28mitochondrial respiratory chain complex assembly (GO:0033108)3.41149656
29cullin deneddylation (GO:0010388)3.41041617
30proteasome assembly (GO:0043248)3.40986107
31translational termination (GO:0006415)3.39810758
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38864376
33protein complex biogenesis (GO:0070271)3.36177108
34positive regulation of ligase activity (GO:0051351)3.33383508
35CENP-A containing nucleosome assembly (GO:0034080)3.32359239
36chromatin remodeling at centromere (GO:0031055)3.31702755
37L-methionine biosynthetic process (GO:0071265)3.30196180
38amino acid salvage (GO:0043102)3.30196180
39L-methionine salvage (GO:0071267)3.30196180
40folic acid-containing compound biosynthetic process (GO:0009396)3.29376848
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29128307
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29128307
43protein deneddylation (GO:0000338)3.28562013
44translational elongation (GO:0006414)3.28456894
45transcription from mitochondrial promoter (GO:0006390)3.27240490
46ribosomal large subunit biogenesis (GO:0042273)3.23158142
47ribonucleoprotein complex biogenesis (GO:0022613)3.22792001
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22180596
49establishment of viral latency (GO:0019043)3.21910286
50DNA deamination (GO:0045006)3.21677686
51regulation of ubiquitin-protein transferase activity (GO:0051438)3.21507225
52cellular protein complex disassembly (GO:0043624)3.20178687
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.19349412
54ribosome assembly (GO:0042255)3.16213347
55peptidyl-histidine modification (GO:0018202)3.15821505
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15132204
57L-phenylalanine metabolic process (GO:0006558)3.15132204
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14995594
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14569705
60pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14459850
61respiratory chain complex IV assembly (GO:0008535)3.14031549
62ribosome biogenesis (GO:0042254)3.13448467
63protein neddylation (GO:0045116)3.13244874
64pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.12323418
65metallo-sulfur cluster assembly (GO:0031163)3.11969390
66iron-sulfur cluster assembly (GO:0016226)3.11969390
67translational initiation (GO:0006413)3.11010698
68mitotic metaphase plate congression (GO:0007080)3.10931643
69inner mitochondrial membrane organization (GO:0007007)3.10361871
70IMP biosynthetic process (GO:0006188)3.09415488
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.08460913
72folic acid metabolic process (GO:0046655)3.08159962
73guanosine-containing compound biosynthetic process (GO:1901070)3.07214572
74regulation of ligase activity (GO:0051340)3.07121383
75lysine metabolic process (GO:0006553)3.06442453
76lysine catabolic process (GO:0006554)3.06442453
77branched-chain amino acid catabolic process (GO:0009083)3.03169207
78valine metabolic process (GO:0006573)3.03087701
79tricarboxylic acid cycle (GO:0006099)3.02979752
80pteridine-containing compound biosynthetic process (GO:0042559)3.00874068
81DNA strand elongation involved in DNA replication (GO:0006271)3.00050657
82quinone biosynthetic process (GO:1901663)2.98192334
83ubiquinone biosynthetic process (GO:0006744)2.98192334
84IMP metabolic process (GO:0046040)2.97685661
85termination of RNA polymerase III transcription (GO:0006386)2.97409639
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.97409639
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96289560
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95626813
89rRNA modification (GO:0000154)2.95304509
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.92107299
91L-phenylalanine catabolic process (GO:0006559)2.92107299
92cotranslational protein targeting to membrane (GO:0006613)2.90537426
93cellular component biogenesis (GO:0044085)2.89159576
94DNA strand elongation (GO:0022616)2.88933700
95DNA replication initiation (GO:0006270)2.88427842
96protein targeting to ER (GO:0045047)2.88108429
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87187899
98telomere maintenance via semi-conservative replication (GO:0032201)2.86606908
99serine family amino acid metabolic process (GO:0009069)2.85901287
100* translation (GO:0006412)2.85315584
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81360873
102ubiquinone metabolic process (GO:0006743)2.80212218
103DNA unwinding involved in DNA replication (GO:0006268)2.79587615
104regulation of cellular amino acid metabolic process (GO:0006521)2.77895044
105protein localization to endoplasmic reticulum (GO:0070972)2.77203865
106branched-chain amino acid metabolic process (GO:0009081)2.77094906
107glyoxylate metabolic process (GO:0046487)2.77072913
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76435037
109establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76126031
110rRNA processing (GO:0006364)2.75970511
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75559860
112NADH metabolic process (GO:0006734)2.71209891
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70349693
114negative regulation of ligase activity (GO:0051352)2.70349693
115sulfur amino acid biosynthetic process (GO:0000097)2.69786700
116respiratory electron transport chain (GO:0022904)2.69394713
117viral life cycle (GO:0019058)2.68969378
118AMP metabolic process (GO:0046033)2.68917232
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68728690
1202-oxoglutarate metabolic process (GO:0006103)2.67721712
121aromatic amino acid family catabolic process (GO:0009074)2.66855954
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66803527
123mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65277542
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.65277542
125NADH dehydrogenase complex assembly (GO:0010257)2.65277542
126rRNA metabolic process (GO:0016072)2.64555567
127intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63998434
128signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63998434
129indole-containing compound catabolic process (GO:0042436)2.63784960
130indolalkylamine catabolic process (GO:0046218)2.63784960
131tryptophan catabolic process (GO:0006569)2.63784960
132electron transport chain (GO:0022900)2.63625720
133regulation of mitochondrial translation (GO:0070129)2.63590360
134pseudouridine synthesis (GO:0001522)2.63431650
135fatty acid beta-oxidation (GO:0006635)2.63217838
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62402283
137signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62402283
138signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62402283
139kynurenine metabolic process (GO:0070189)2.61866499
140aspartate family amino acid metabolic process (GO:0009066)2.60176977
141methionine biosynthetic process (GO:0009086)2.60047642
142signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58562040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.74489174
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98268239
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96492031
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51737695
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.44270437
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21954420
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.19485332
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.99178902
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.98186938
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95143611
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93721096
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81988611
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75471513
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62816499
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58040465
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40412175
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39497182
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38452990
19VDR_23849224_ChIP-Seq_CD4+_Human2.37558570
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31548407
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28172605
22XRN2_22483619_ChIP-Seq_HELA_Human2.25266156
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24227250
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13705851
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10850206
26FOXP3_21729870_ChIP-Seq_TREG_Human2.08601265
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.07279366
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06184362
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04573897
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03769004
31* DCP1A_22483619_ChIP-Seq_HELA_Human2.01104091
32GABP_19822575_ChIP-Seq_HepG2_Human1.91289786
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86397240
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85839966
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83296210
36* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79072889
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.76421583
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74120716
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72975685
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.71324241
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70992154
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70246849
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69830538
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69827441
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69368796
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67831987
47AR_21909140_ChIP-Seq_LNCAP_Human1.62774135
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60397640
49ELK1_19687146_ChIP-ChIP_HELA_Human1.60381543
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58005266
51TTF2_22483619_ChIP-Seq_HELA_Human1.57157832
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56805223
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.55032203
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54701029
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52786553
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52708963
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44728244
58GATA1_22025678_ChIP-Seq_K562_Human1.44249341
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44239334
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44139529
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41597824
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38504993
63* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37223588
64CIITA_25753668_ChIP-Seq_RAJI_Human1.34844800
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33053908
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27496402
67ZNF263_19887448_ChIP-Seq_K562_Human1.26289513
68* KDM5A_27292631_Chip-Seq_BREAST_Human1.24984419
69* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.22575581
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.19172802
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17509536
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16067064
73* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13896874
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13703146
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11678352
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11517042
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11141943
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10560980
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09887327
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08071372
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05826218
82TFEB_21752829_ChIP-Seq_HELA_Human1.03896904
83MYC_22102868_ChIP-Seq_BL_Human1.03257343
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.03002588
85MYC_18940864_ChIP-ChIP_HL60_Human0.99814199
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98967813
87SPI1_23547873_ChIP-Seq_NB4_Human0.98725790
88* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97998702
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96205111
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95891937
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95774763
92LXR_22158963_ChIP-Seq_LIVER_Mouse0.95289478
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95275575
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95022237
95CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93972601
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.92209162
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.91807444
98* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91796104
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91430214
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90136058
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89524774
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89498998
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87956439
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87878244
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87594968
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.86036723
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85255808
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85231753
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84392354
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83061584
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82872517
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82657304
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79610738
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79395010
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.79394407
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79071705
117* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78408159
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.75998977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.62763330
2MP0002139_abnormal_hepatobiliary_system4.07389756
3MP0005360_urolithiasis3.21051759
4MP0009840_abnormal_foam_cell2.93417744
5MP0003693_abnormal_embryo_hatching2.87081556
6MP0006036_abnormal_mitochondrial_physio2.81726182
7MP0005085_abnormal_gallbladder_physiolo2.76058073
8MP0003186_abnormal_redox_activity2.71516221
9MP0005365_abnormal_bile_salt2.68252255
10MP0004957_abnormal_blastocyst_morpholog2.62614970
11MP0006292_abnormal_olfactory_placode2.59010838
12MP0003111_abnormal_nucleus_morphology2.37497133
13MP0010094_abnormal_chromosome_stability2.36580082
14MP0003077_abnormal_cell_cycle2.16625723
15MP0009697_abnormal_copulation2.12976274
16MP0008875_abnormal_xenobiotic_pharmacok2.09989718
17MP0008057_abnormal_DNA_replication2.08264047
18MP0003646_muscle_fatigue2.03868108
19MP0001764_abnormal_homeostasis2.00278507
20MP0001346_abnormal_lacrimal_gland1.97313015
21MP0000372_irregular_coat_pigmentation1.97063007
22MP0008058_abnormal_DNA_repair1.92040333
23MP0005451_abnormal_body_composition1.90683102
24MP0004147_increased_porphyrin_level1.85455584
25MP0001529_abnormal_vocalization1.84640535
26MP0005332_abnormal_amino_acid1.83724407
27MP0008007_abnormal_cellular_replicative1.81490558
28MP0006035_abnormal_mitochondrial_morpho1.79183254
29MP0003656_abnormal_erythrocyte_physiolo1.77634245
30MP0010030_abnormal_orbit_morphology1.74444612
31MP0003718_maternal_effect1.69920687
32MP0008789_abnormal_olfactory_epithelium1.64927857
33MP0001853_heart_inflammation1.62179121
34MP0009333_abnormal_splenocyte_physiolog1.61999152
35MP0010329_abnormal_lipoprotein_level1.57133361
36MP0003221_abnormal_cardiomyocyte_apopto1.55508275
37MP0000609_abnormal_liver_physiology1.48825177
38MP0002254_reproductive_system_inflammat1.46517894
39MP0002396_abnormal_hematopoietic_system1.45028048
40MP0000537_abnormal_urethra_morphology1.44848237
41MP0004084_abnormal_cardiac_muscle1.44742042
42MP0005319_abnormal_enzyme/_coenzyme1.41572469
43MP0002132_abnormal_respiratory_system1.36760644
44MP0005501_abnormal_skin_physiology1.34243894
45MP0002163_abnormal_gland_morphology1.33901579
46MP0001873_stomach_inflammation1.33706836
47MP0001293_anophthalmia1.32303342
48MP0004036_abnormal_muscle_relaxation1.31687295
49MP0003191_abnormal_cellular_cholesterol1.30717187
50MP0003763_abnormal_thymus_physiology1.29606605
51MP0005330_cardiomyopathy1.29371306
52MP0001730_embryonic_growth_arrest1.25917149
53MP0001666_abnormal_nutrient_absorption1.24085810
54MP0008995_early_reproductive_senescence1.21465640
55MP0005266_abnormal_metabolism1.21082500
56MP0003315_abnormal_perineum_morphology1.19002256
57MP0001835_abnormal_antigen_presentation1.16004015
58MP0005584_abnormal_enzyme/coenzyme_acti1.15021983
59MP0008932_abnormal_embryonic_tissue1.13094759
60MP0000749_muscle_degeneration1.12929546
61MP0002210_abnormal_sex_determination1.09904020
62MP0002938_white_spotting1.09795318
63MP0002085_abnormal_embryonic_tissue1.09486249
64MP0000689_abnormal_spleen_morphology1.09158710
65MP0002796_impaired_skin_barrier1.08584952
66MP0009643_abnormal_urine_homeostasis1.07931245
67MP0001881_abnormal_mammary_gland1.06961661
68MP0005394_taste/olfaction_phenotype1.06112455
69MP0005499_abnormal_olfactory_system1.06112455
70MP0005083_abnormal_biliary_tract1.05639582
71MP0002877_abnormal_melanocyte_morpholog1.05259707
72MP0001661_extended_life_span1.05012925
73MP0000598_abnormal_liver_morphology1.04467977
74MP0002269_muscular_atrophy1.04111104
75MP0005408_hypopigmentation1.02620582
76MP0001929_abnormal_gametogenesis1.02261736
77MP0001727_abnormal_embryo_implantation1.02054844
78MP0009672_abnormal_birth_weight1.01916571
79MP0003941_abnormal_skin_development0.98672901
80MP0002160_abnormal_reproductive_system0.98419061
81MP0000049_abnormal_middle_ear0.98224597
82MP0002722_abnormal_immune_system0.97161260
83MP0002234_abnormal_pharynx_morphology0.96426519
84MP0002088_abnormal_embryonic_growth/wei0.96003190
85MP0002118_abnormal_lipid_homeostasis0.95479357
86MP0003567_abnormal_fetal_cardiomyocyte0.95256159
87MP0003786_premature_aging0.94831712
88MP0000747_muscle_weakness0.94075507
89MP0002084_abnormal_developmental_patter0.93881914
90MP0005376_homeostasis/metabolism_phenot0.92465098
91MP0008469_abnormal_protein_level0.91495444
92MP0002398_abnormal_bone_marrow0.91405314
93MP0006054_spinal_hemorrhage0.91209246
94MP0001145_abnormal_male_reproductive0.90872652
95MP0000685_abnormal_immune_system0.90489563
96MP0005671_abnormal_response_to0.90451133
97MP0002751_abnormal_autonomic_nervous0.90116760
98MP0001919_abnormal_reproductive_system0.88880337
99MP0000653_abnormal_sex_gland0.88503766
100MP0002019_abnormal_tumor_incidence0.88231252
101MP0009379_abnormal_foot_pigmentation0.88142896
102MP0008877_abnormal_DNA_methylation0.87765894
103MP0009785_altered_susceptibility_to0.87253897
104MP0004019_abnormal_vitamin_homeostasis0.85259730
105MP0001800_abnormal_humoral_immune0.84465022
106MP0000750_abnormal_muscle_regeneration0.84353354
107MP0003123_paternal_imprinting0.83551942
108MP0000313_abnormal_cell_death0.83368874
109MP0003937_abnormal_limbs/digits/tail_de0.82892948
110MP0002429_abnormal_blood_cell0.81940760
111MP0002080_prenatal_lethality0.81419838
112MP0005075_abnormal_melanosome_morpholog0.80898811
113MP0002837_dystrophic_cardiac_calcinosis0.80421067
114MP0001697_abnormal_embryo_size0.79726012
115MP0002111_abnormal_tail_morphology0.79444120
116MP0002736_abnormal_nociception_after0.79112197
117MP0006072_abnormal_retinal_apoptosis0.78979192
118MP0005379_endocrine/exocrine_gland_phen0.77627933
119MP0000358_abnormal_cell_content/0.77130559
120MP0000350_abnormal_cell_proliferation0.76771878
121MP0005389_reproductive_system_phenotype0.76633330
122MP0003252_abnormal_bile_duct0.75735218
123MP0005058_abnormal_lysosome_morphology0.75211668
124MP0009763_increased_sensitivity_to0.74826253
125MP0005410_abnormal_fertilization0.74079210
126MP0005025_abnormal_response_to0.73928447
127MP0005636_abnormal_mineral_homeostasis0.73694933
128MP0002697_abnormal_eye_size0.73549705
129MP0004215_abnormal_myocardial_fiber0.73414398
130MP0005464_abnormal_platelet_physiology0.73020807
131MP0004130_abnormal_muscle_cell0.72492104
132MP0000751_myopathy0.72371016
133MP0005666_abnormal_adipose_tissue0.71539112
134MP0001544_abnormal_cardiovascular_syste0.71472186
135MP0005385_cardiovascular_system_phenoty0.71472186
136MP0001188_hyperpigmentation0.70886642
137MP0001672_abnormal_embryogenesis/_devel0.70539894
138MP0005380_embryogenesis_phenotype0.70539894
139MP0005670_abnormal_white_adipose0.70360735
140MP0001119_abnormal_female_reproductive0.69882816
141MP0002102_abnormal_ear_morphology0.69849831
142MP0000716_abnormal_immune_system0.69728972
143MP0003698_abnormal_male_reproductive0.69481985
144MP0002166_altered_tumor_susceptibility0.69257790
145MP0000490_abnormal_crypts_of0.69086945
146MP0008873_increased_physiological_sensi0.68873476
147MP0002233_abnormal_nose_morphology0.68697747
148MP0000343_altered_response_to0.68372246
149MP0002723_abnormal_immune_serum0.67200817
150MP0002277_abnormal_respiratory_mucosa0.67069263
151MP0003984_embryonic_growth_retardation0.66688235
152MP0004233_abnormal_muscle_weight0.66583060
153MP0001286_abnormal_eye_development0.65890385
154MP0000627_abnormal_mammary_gland0.62917584
155MP0000647_abnormal_sebaceous_gland0.61719834
156MP0003938_abnormal_ear_development0.60885360
157MP0004197_abnormal_fetal_growth/weight/0.60812962
158MP0002161_abnormal_fertility/fecundity0.60175535
159MP0010307_abnormal_tumor_latency0.57333963

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.20422621
2Hepatocellular necrosis (HP:0001404)3.96168309
3Microvesicular hepatic steatosis (HP:0001414)3.93930552
4Acute encephalopathy (HP:0006846)3.78987142
5Abnormality of glycolysis (HP:0004366)3.76788700
6Increased serum pyruvate (HP:0003542)3.76788700
7Acute necrotizing encephalopathy (HP:0006965)3.70106593
8Cerebral edema (HP:0002181)3.56488086
9Abnormal mitochondria in muscle tissue (HP:0008316)3.51771162
10Hyperglycinuria (HP:0003108)3.49776369
11Abnormality of fatty-acid metabolism (HP:0004359)3.49773912
12Increased CSF lactate (HP:0002490)3.49732699
13Hyperammonemia (HP:0001987)3.42102600
14Increased serum lactate (HP:0002151)3.40145091
15Hypobetalipoproteinemia (HP:0003563)3.37912038
16Abnormality of cells of the erythroid lineage (HP:0012130)3.37391864
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36725151
18Abnormality of serine family amino acid metabolism (HP:0010894)3.35710605
19Abnormality of glycine metabolism (HP:0010895)3.35710605
20Mitochondrial inheritance (HP:0001427)3.31738560
21Abnormal number of erythroid precursors (HP:0012131)3.29957244
22Rhabdomyolysis (HP:0003201)3.21988265
23Type I transferrin isoform profile (HP:0003642)3.17950534
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17920672
25Abnormality of alanine metabolism (HP:0010916)3.17920672
26Hyperalaninemia (HP:0003348)3.17920672
27Lactic acidosis (HP:0003128)3.17686415
28Hyperglycinemia (HP:0002154)3.16620848
29Birth length less than 3rd percentile (HP:0003561)3.16109094
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.14641334
31Dicarboxylic aciduria (HP:0003215)3.14641334
32Testicular atrophy (HP:0000029)3.12106949
33Myoglobinuria (HP:0002913)3.08005843
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04996993
35Lipid accumulation in hepatocytes (HP:0006561)3.03651207
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01751427
37Lethargy (HP:0001254)2.99142467
383-Methylglutaconic aciduria (HP:0003535)2.98531175
39Progressive macrocephaly (HP:0004481)2.91186945
40Increased muscle lipid content (HP:0009058)2.89364515
41Abnormality of serum amino acid levels (HP:0003112)2.88732756
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86262610
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86262610
44Hypoglycemic coma (HP:0001325)2.78703301
45Multiple enchondromatosis (HP:0005701)2.78347936
46Progressive muscle weakness (HP:0003323)2.66196603
47CNS demyelination (HP:0007305)2.64874357
48Reticulocytopenia (HP:0001896)2.63622941
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63275981
50Xanthomatosis (HP:0000991)2.62019586
51Exercise intolerance (HP:0003546)2.60732775
52Increased hepatocellular lipid droplets (HP:0006565)2.59908707
53Intrahepatic cholestasis (HP:0001406)2.59090291
54Reduced antithrombin III activity (HP:0001976)2.57132783
55Increased intramyocellular lipid droplets (HP:0012240)2.56096976
56Respiratory failure (HP:0002878)2.54485587
57Cerebral hypomyelination (HP:0006808)2.53576625
58Nausea (HP:0002018)2.51149048
59Abnormality of pyrimidine metabolism (HP:0004353)2.49174164
60Respiratory difficulties (HP:0002880)2.45128619
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44303368
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44074628
63Abnormal protein N-linked glycosylation (HP:0012347)2.44074628
64Abnormal protein glycosylation (HP:0012346)2.44074628
65Abnormal glycosylation (HP:0012345)2.44074628
66Meckel diverticulum (HP:0002245)2.42448478
67Generalized aminoaciduria (HP:0002909)2.39412428
68Proximal tubulopathy (HP:0000114)2.38756679
69Macrocytic anemia (HP:0001972)2.38686275
70Progressive external ophthalmoplegia (HP:0000590)2.36824155
71Abnormality of the ileum (HP:0001549)2.36649201
72Abnormality of methionine metabolism (HP:0010901)2.34629881
73Optic disc pallor (HP:0000543)2.32865286
74Ketosis (HP:0001946)2.32364457
75Hypolipoproteinemia (HP:0010981)2.31951522
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31837273
77Abnormality of the anterior horn cell (HP:0006802)2.30080649
78Degeneration of anterior horn cells (HP:0002398)2.30080649
79Metabolic acidosis (HP:0001942)2.29537660
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29418700
81Abnormality of the preputium (HP:0100587)2.27992800
82Hyperlipoproteinemia (HP:0010980)2.27020137
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25904484
84Methylmalonic acidemia (HP:0002912)2.24950150
85Abnormality of the heme biosynthetic pathway (HP:0010472)2.24482650
86Aplastic anemia (HP:0001915)2.23181253
87Thrombocytosis (HP:0001894)2.18287652
88Renal Fanconi syndrome (HP:0001994)2.16340284
89Brushfield spots (HP:0001088)2.13827897
90Ragged-red muscle fibers (HP:0003200)2.11884300
91Rough bone trabeculation (HP:0100670)2.11084042
92Hyperbilirubinemia (HP:0002904)2.08557025
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07756898
94Chromsome breakage (HP:0040012)2.07578949
95Pancytopenia (HP:0001876)2.05761930
96Prolonged partial thromboplastin time (HP:0003645)2.05147167
97Delayed CNS myelination (HP:0002188)2.04205087
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.03187489
99Megaloblastic anemia (HP:0001889)2.02473022
100Secondary amenorrhea (HP:0000869)2.02430020
101Vomiting (HP:0002013)2.00044613
102Abnormality of the fetal cardiovascular system (HP:0010948)1.99719402
103Abnormal umbilical cord blood vessels (HP:0011403)1.99719402
104Single umbilical artery (HP:0001195)1.99719402
105Microretrognathia (HP:0000308)1.99543197
106Aplasia/Hypoplasia of the uvula (HP:0010293)1.99536722
107Exercise-induced muscle cramps (HP:0003710)1.98012534
108Glycosuria (HP:0003076)1.97598819
109Abnormality of urine glucose concentration (HP:0011016)1.97598819
110Gliosis (HP:0002171)1.97328036
111Leukodystrophy (HP:0002415)1.97196530
112Gout (HP:0001997)1.96829750
113Exertional dyspnea (HP:0002875)1.94105778
114Breast hypoplasia (HP:0003187)1.93342289
115Cholecystitis (HP:0001082)1.93289587
116Abnormal gallbladder physiology (HP:0012438)1.93289587
117Abnormality of the umbilical cord (HP:0010881)1.92498156
118Spastic diplegia (HP:0001264)1.91232930
119Triphalangeal thumb (HP:0001199)1.90310049
120Oral leukoplakia (HP:0002745)1.90299279
121Deep venous thrombosis (HP:0002625)1.90155434
122Abnormality of reticulocytes (HP:0004312)1.89953119
123Emotional lability (HP:0000712)1.88199847
124Pallor (HP:0000980)1.86431414
125Death in infancy (HP:0001522)1.86307565
126Absent thumb (HP:0009777)1.85948452
127Horseshoe kidney (HP:0000085)1.84833171
128Spastic paraparesis (HP:0002313)1.84176602
129Ketoacidosis (HP:0001993)1.83513751
130Cleft eyelid (HP:0000625)1.83342011
131Renal cortical cysts (HP:0000803)1.83182993
132Cholelithiasis (HP:0001081)1.83034353
133Sparse eyelashes (HP:0000653)1.82866768
134Premature ovarian failure (HP:0008209)1.81881946
135Methylmalonic aciduria (HP:0012120)1.81870504
136Colon cancer (HP:0003003)1.80933407
137CNS hypomyelination (HP:0003429)1.70737197
138Cellular immunodeficiency (HP:0005374)1.67034952
139Abnormality of chromosome stability (HP:0003220)1.66983798
140Myelodysplasia (HP:0002863)1.64771787
141Facial cleft (HP:0002006)1.64234775
142Sensory axonal neuropathy (HP:0003390)1.63801330
143Trismus (HP:0000211)1.63002729
144Neoplasm of the adrenal gland (HP:0100631)1.58871613
145Carpal bone hypoplasia (HP:0001498)1.58072894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.82478145
2BUB13.86176581
3NME23.56725136
4BCKDK3.48163947
5STK162.99184589
6EIF2AK12.79067195
7WEE12.68436045
8EIF2AK32.36576794
9TRIM282.20815261
10PLK42.13851974
11VRK12.04041577
12TAF12.02794288
13ZAK1.99438831
14TSSK61.91753574
15EEF2K1.86355026
16IRAK31.83997647
17TESK11.71941144
18SRPK11.69428427
19RPS6KB21.68115698
20OBSCN1.64476666
21MAP4K11.62964078
22CDC71.56581249
23PDK31.56560695
24PDK41.56560695
25ARAF1.55034492
26DYRK31.54594903
27MAP2K31.49100796
28MAP3K91.47933344
29TESK21.47565305
30PKN21.46688843
31FLT31.45162406
32NEK11.44740733
33PBK1.44274930
34CCNB11.40587592
35STK101.36779681
36MAP3K111.34991682
37CSNK1G31.32023735
38NEK21.31600394
39TTK1.30720943
40DAPK11.28724659
41MAP3K121.25345984
42MST41.23768742
43MAP4K21.23216764
44MYLK1.22461595
45PIM21.18671678
46PLK11.18492305
47BRSK21.17176281
48AURKB1.16389381
49KDR1.12978482
50RPS6KA41.11386767
51STK41.08889206
52ACVR1B1.08257831
53TLK11.03578591
54CSNK1A1L1.01253020
55PASK1.00613812
56PINK11.00208709
57CSNK1G10.97839077
58PLK30.96806388
59SMG10.95590544
60JAK30.93726535
61TTN0.91903334
62TGFBR10.91324562
63PIM10.89500099
64PDK20.88221193
65MAP3K80.86339526
66MKNK10.85785412
67TBK10.84721447
68LRRK20.84626869
69TYK20.84493899
70NUAK10.84486502
71DYRK20.82804155
72IRAK40.81529607
73SCYL20.81330816
74MAPK110.80966958
75CDK40.80844371
76AURKA0.80146452
77TEC0.80064678
78ILK0.76388440
79GRK60.76067178
80MUSK0.74593266
81LMTK20.74406867
82MAP3K50.74038621
83NEK90.73930305
84MAP2K70.73672622
85BTK0.71821052
86EIF2AK20.71773871
87ATR0.71675401
88BRSK10.71616527
89CSNK1G20.71397481
90MAPKAPK30.71220157
91CDK70.69519117
92LIMK10.68804546
93TXK0.68378320
94CDK80.67902005
95TRIB30.67771774
96BRAF0.67231418
97ERBB30.66979955
98ZAP700.64778808
99CSNK2A10.61229028
100CSNK2A20.60440919
101IKBKB0.59658303
102PRKCI0.59495022
103NME10.57917311
104STK240.57589354
105SIK30.52845945
106PAK10.52787352
107EPHA20.52656909
108DAPK30.49912336
109ABL20.49301541
110MAP3K30.48680270
111BCR0.48380212
112CHEK20.48274054
113MAPKAPK50.47968992
114BMPR20.47373079
115MAP3K130.47130196
116CHEK10.46633320
117ATM0.46263073
118RPS6KA50.46024249
119KIT0.45711787
120WNK30.41826063
121MAP3K140.41586689
122MARK30.41476281
123PAK40.40895295
124CLK10.40752655
125CSF1R0.40743117
126TIE10.40708172
127AKT20.40079388
128CDK190.39832127
129ALK0.39347365
130LCK0.38931950
131CDK20.34305075
132MAPK40.34158249
133MST1R0.31157732
134CDK10.30489166
135MKNK20.29279620
136CAMK2G0.28592896
137CSNK1E0.28127749
138CDK140.24731206
139CDK11A0.23922576
140RAF10.23414693
141TAOK20.23406237

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.86925594
2* Ribosome_Homo sapiens_hsa030102.81156962
3RNA polymerase_Homo sapiens_hsa030202.52981707
4DNA replication_Homo sapiens_hsa030302.49470475
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44594632
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43617312
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36347400
8Propanoate metabolism_Homo sapiens_hsa006402.24200760
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12999243
10Fatty acid degradation_Homo sapiens_hsa000712.12771566
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09331750
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94600553
13Pyrimidine metabolism_Homo sapiens_hsa002401.83675900
14Mismatch repair_Homo sapiens_hsa034301.83670631
15Carbon metabolism_Homo sapiens_hsa012001.80885849
16Oxidative phosphorylation_Homo sapiens_hsa001901.78672926
17One carbon pool by folate_Homo sapiens_hsa006701.78631353
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.75083108
19Parkinsons disease_Homo sapiens_hsa050121.74991306
20Folate biosynthesis_Homo sapiens_hsa007901.74315096
21Biosynthesis of amino acids_Homo sapiens_hsa012301.66838113
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64511341
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.62513373
24Fatty acid elongation_Homo sapiens_hsa000621.61340653
25Fatty acid metabolism_Homo sapiens_hsa012121.59868996
26Spliceosome_Homo sapiens_hsa030401.54204873
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53009402
28Peroxisome_Homo sapiens_hsa041461.51302784
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.49740205
30RNA transport_Homo sapiens_hsa030131.47559628
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46812707
32Base excision repair_Homo sapiens_hsa034101.46621846
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43836158
34Pyruvate metabolism_Homo sapiens_hsa006201.42426663
35Nucleotide excision repair_Homo sapiens_hsa034201.38833963
36beta-Alanine metabolism_Homo sapiens_hsa004101.34432196
37Vitamin B6 metabolism_Homo sapiens_hsa007501.33295379
38Sulfur relay system_Homo sapiens_hsa041221.32653881
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32317921
40Non-homologous end-joining_Homo sapiens_hsa034501.31720409
41Selenocompound metabolism_Homo sapiens_hsa004501.31667956
42Pentose phosphate pathway_Homo sapiens_hsa000301.30873065
43Tryptophan metabolism_Homo sapiens_hsa003801.26571897
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25404065
45Butanoate metabolism_Homo sapiens_hsa006501.21918215
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21625955
47Homologous recombination_Homo sapiens_hsa034401.21527696
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18311189
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16811634
50Huntingtons disease_Homo sapiens_hsa050161.15178831
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12017475
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07904780
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04414368
54RNA degradation_Homo sapiens_hsa030181.01279441
55Arginine biosynthesis_Homo sapiens_hsa002200.99766381
56PPAR signaling pathway_Homo sapiens_hsa033200.96160389
57Alzheimers disease_Homo sapiens_hsa050100.94897142
58Glutathione metabolism_Homo sapiens_hsa004800.92179461
59Purine metabolism_Homo sapiens_hsa002300.91214344
60Arginine and proline metabolism_Homo sapiens_hsa003300.91207771
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90759170
62Phenylalanine metabolism_Homo sapiens_hsa003600.90236545
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87640582
64Cell cycle_Homo sapiens_hsa041100.86298485
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84676526
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82584222
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.81546341
68Metabolic pathways_Homo sapiens_hsa011000.81511363
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80109747
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79444066
71N-Glycan biosynthesis_Homo sapiens_hsa005100.79349043
72Sulfur metabolism_Homo sapiens_hsa009200.79122803
73Histidine metabolism_Homo sapiens_hsa003400.77757897
74Tyrosine metabolism_Homo sapiens_hsa003500.76866391
75Protein export_Homo sapiens_hsa030600.75067772
76Fructose and mannose metabolism_Homo sapiens_hsa000510.72845393
77Caffeine metabolism_Homo sapiens_hsa002320.71944415
78Chemical carcinogenesis_Homo sapiens_hsa052040.71771307
79Basal transcription factors_Homo sapiens_hsa030220.71504798
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71426244
81Galactose metabolism_Homo sapiens_hsa000520.65496876
82Starch and sucrose metabolism_Homo sapiens_hsa005000.63302257
83Steroid biosynthesis_Homo sapiens_hsa001000.61350706
84Retinol metabolism_Homo sapiens_hsa008300.61126825
85Nitrogen metabolism_Homo sapiens_hsa009100.59548549
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58277680
87Systemic lupus erythematosus_Homo sapiens_hsa053220.57527677
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56980442
89Oocyte meiosis_Homo sapiens_hsa041140.51966688
90Fanconi anemia pathway_Homo sapiens_hsa034600.51903696
91Vitamin digestion and absorption_Homo sapiens_hsa049770.51234713
92Epstein-Barr virus infection_Homo sapiens_hsa051690.48689769
93p53 signaling pathway_Homo sapiens_hsa041150.48048109
94Complement and coagulation cascades_Homo sapiens_hsa046100.47886179
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.46234360
96Fat digestion and absorption_Homo sapiens_hsa049750.42471161
97Primary immunodeficiency_Homo sapiens_hsa053400.41636177
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40273541
99Legionellosis_Homo sapiens_hsa051340.38126710
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35874907
101Cardiac muscle contraction_Homo sapiens_hsa042600.32328478
102mRNA surveillance pathway_Homo sapiens_hsa030150.30085427
103Vibrio cholerae infection_Homo sapiens_hsa051100.27161455
104Herpes simplex infection_Homo sapiens_hsa051680.26812869
105Antigen processing and presentation_Homo sapiens_hsa046120.26702818
106Fatty acid biosynthesis_Homo sapiens_hsa000610.26635721
107Regulation of autophagy_Homo sapiens_hsa041400.25707224
108Alcoholism_Homo sapiens_hsa050340.23716053
109Thyroid cancer_Homo sapiens_hsa052160.21731116
110Viral carcinogenesis_Homo sapiens_hsa052030.17179005
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14259701
112Collecting duct acid secretion_Homo sapiens_hsa049660.12647544
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12579206
114Shigellosis_Homo sapiens_hsa051310.11243470
115HTLV-I infection_Homo sapiens_hsa051660.06034063
116Phototransduction_Homo sapiens_hsa047440.05945345
117TGF-beta signaling pathway_Homo sapiens_hsa043500.03202475

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