MRPL3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.98630786
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.54878277
3cytidine metabolic process (GO:0046087)6.49326992
4cytidine catabolic process (GO:0006216)6.49326992
5cytidine deamination (GO:0009972)6.49326992
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.93240675
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.14742705
8water-soluble vitamin biosynthetic process (GO:0042364)4.78066409
9signal peptide processing (GO:0006465)4.75141732
10purine-containing compound salvage (GO:0043101)4.65201391
11activated T cell proliferation (GO:0050798)4.44067457
12rRNA modification (GO:0000154)4.17098303
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06964164
14ATP synthesis coupled proton transport (GO:0015986)4.03191612
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.03191612
16IMP biosynthetic process (GO:0006188)3.99983715
17peptidyl-histidine modification (GO:0018202)3.85188797
18antigen processing and presentation via MHC class Ib (GO:0002475)3.79773696
19regulation of chronic inflammatory response (GO:0002676)3.79405276
20purine nucleotide salvage (GO:0032261)3.79031507
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.73336394
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.73336394
23protein neddylation (GO:0045116)3.67103313
24regulation of activation of Janus kinase activity (GO:0010533)3.61035320
25adenosine metabolic process (GO:0046085)3.57230163
26regulation of cellular amino acid metabolic process (GO:0006521)3.56929759
27production of molecular mediator involved in inflammatory response (GO:0002532)3.56639197
28organic cation transport (GO:0015695)3.52794903
29cullin deneddylation (GO:0010388)3.48446638
30inner mitochondrial membrane organization (GO:0007007)3.47656335
31metallo-sulfur cluster assembly (GO:0031163)3.47557797
32iron-sulfur cluster assembly (GO:0016226)3.47557797
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40637411
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.34742918
35mast cell activation involved in immune response (GO:0002279)3.32449395
36mast cell degranulation (GO:0043303)3.32449395
37cytolysis (GO:0019835)3.32071192
38nucleobase biosynthetic process (GO:0046112)3.30661278
39purine nucleobase biosynthetic process (GO:0009113)3.29504366
40preassembly of GPI anchor in ER membrane (GO:0016254)3.22754410
41protein deneddylation (GO:0000338)3.21589729
42proteasome assembly (GO:0043248)3.19453354
43chaperone-mediated protein transport (GO:0072321)3.19203387
44GPI anchor metabolic process (GO:0006505)3.15278174
45rRNA methylation (GO:0031167)3.15173968
46negative regulation by host of viral transcription (GO:0043922)3.12938471
47GPI anchor biosynthetic process (GO:0006506)3.10526444
48negative regulation of T cell apoptotic process (GO:0070233)3.09788274
49positive regulation of translational initiation (GO:0045948)3.09036145
50piRNA metabolic process (GO:0034587)3.09017399
51urate metabolic process (GO:0046415)3.07864991
52dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.00881804
53serotonin receptor signaling pathway (GO:0007210)3.00591380
54respiratory chain complex IV assembly (GO:0008535)2.99340838
55regulation of meiosis I (GO:0060631)2.99132935
56pyrimidine nucleoside catabolic process (GO:0046135)2.97149637
57nucleotide salvage (GO:0043173)2.97118941
58GMP metabolic process (GO:0046037)2.96019993
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94987711
60IMP metabolic process (GO:0046040)2.92071765
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90701803
62negative regulation of telomere maintenance (GO:0032205)2.86620145
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86449141
64regulation of cellular amine metabolic process (GO:0033238)2.85121634
65regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.80692262
66behavioral response to nicotine (GO:0035095)2.80096688
67protoporphyrinogen IX biosynthetic process (GO:0006782)2.80088068
68intracellular protein transmembrane import (GO:0044743)2.79671884
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78049419
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78049419
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78049419
72protein-cofactor linkage (GO:0018065)2.76648290
73positive regulation of interleukin-8 secretion (GO:2000484)2.76452544
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75891689
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75891689
76pteridine-containing compound biosynthetic process (GO:0042559)2.71087145
77electron transport chain (GO:0022900)2.70203871
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69404693
79negative regulation of viral genome replication (GO:0045071)2.69269835
80positive regulation of defense response to virus by host (GO:0002230)2.69018224
81regulation of interleukin-8 secretion (GO:2000482)2.68361928
82leukotriene biosynthetic process (GO:0019370)2.67679726
83tRNA modification (GO:0006400)2.67623467
84cellular ketone body metabolic process (GO:0046950)2.67038063
85respiratory electron transport chain (GO:0022904)2.65685886
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63610748
87signal transduction involved in DNA damage checkpoint (GO:0072422)2.63610748
88eosinophil chemotaxis (GO:0048245)2.62735461
89cytochrome complex assembly (GO:0017004)2.62647748
90negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60466855
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60315758
92tRNA processing (GO:0008033)2.59211759
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.59059757
94protein homotrimerization (GO:0070207)2.57721385
95protein complex biogenesis (GO:0070271)2.56735152
96pyrimidine ribonucleoside metabolic process (GO:0046131)2.55588042
97negative regulation of ligase activity (GO:0051352)2.55456580
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55456580
99positive regulation of histone H3-K4 methylation (GO:0051571)2.55055547
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53978252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.41070645
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80899089
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.64364552
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38589417
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.21182229
6VDR_22108803_ChIP-Seq_LS180_Human3.16700066
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99313029
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.91713168
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91496012
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80062333
11VDR_23849224_ChIP-Seq_CD4+_Human2.73332910
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68026241
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49359634
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48173733
15IGF1R_20145208_ChIP-Seq_DFB_Human2.42163326
16ZNF274_21170338_ChIP-Seq_K562_Hela2.27736393
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.19100860
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13254777
19FOXP3_21729870_ChIP-Seq_TREG_Human2.02561310
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.96899710
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95725462
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89635383
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.84522289
24GATA1_22025678_ChIP-Seq_K562_Human1.83849582
25GBX2_23144817_ChIP-Seq_PC3_Human1.83316407
26E2F7_22180533_ChIP-Seq_HELA_Human1.83015756
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81638839
28TP53_22573176_ChIP-Seq_HFKS_Human1.76474119
29TAF15_26573619_Chip-Seq_HEK293_Human1.76182074
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71392531
31EWS_26573619_Chip-Seq_HEK293_Human1.69716937
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.66449881
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.59028433
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57607357
35ELK1_19687146_ChIP-ChIP_HELA_Human1.55358015
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54980229
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53060847
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52687930
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47293157
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47174316
41ER_23166858_ChIP-Seq_MCF-7_Human1.46671222
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45071475
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.41869235
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41564214
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.39903575
46MYC_18940864_ChIP-ChIP_HL60_Human1.37470830
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.37011744
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34233281
49GABP_19822575_ChIP-Seq_HepG2_Human1.33438448
50AR_20517297_ChIP-Seq_VCAP_Human1.33203983
51P300_19829295_ChIP-Seq_ESCs_Human1.32925169
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30988051
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.27438359
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27438359
55GATA3_26560356_Chip-Seq_TH2_Human1.26293157
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25172352
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23988327
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.20693730
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19742619
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19256449
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19038718
62CBP_20019798_ChIP-Seq_JUKART_Human1.19038718
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18131577
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17763418
65NANOG_19829295_ChIP-Seq_ESCs_Human1.16418476
66SOX2_19829295_ChIP-Seq_ESCs_Human1.16418476
67DCP1A_22483619_ChIP-Seq_HELA_Human1.16087048
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11836336
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11387579
70MYB_26560356_Chip-Seq_TH2_Human1.10295095
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.10283137
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07240861
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03471883
74IRF1_19129219_ChIP-ChIP_H3396_Human1.01466544
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01339038
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01109989
77ERG_20517297_ChIP-Seq_VCAP_Human0.98795563
78GATA3_26560356_Chip-Seq_TH1_Human0.97560610
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96829137
80NANOG_20526341_ChIP-Seq_ESCs_Human0.95209758
81MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92888261
82ELK1_22589737_ChIP-Seq_MCF10A_Human0.92347966
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92256139
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.92172489
85TTF2_22483619_ChIP-Seq_HELA_Human0.91955538
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91603950
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90304535
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89181838
89STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88837033
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.88472724
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88348871
92NCOR_22424771_ChIP-Seq_293T_Human0.88263863
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.88185506
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86919233
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86271067
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.86251865
97TCF4_22108803_ChIP-Seq_LS180_Human0.85667849
98MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85461658
99E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85071864
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84560007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.24772396
2MP0008877_abnormal_DNA_methylation3.36743804
3MP0003195_calcinosis3.20804978
4MP0004147_increased_porphyrin_level3.02400101
5MP0002254_reproductive_system_inflammat3.00804301
6MP0003763_abnormal_thymus_physiology2.62290571
7MP0002876_abnormal_thyroid_physiology2.52667753
8MP0009697_abnormal_copulation2.45311574
9MP0002102_abnormal_ear_morphology2.41017916
10MP0003693_abnormal_embryo_hatching2.35581099
11MP0002736_abnormal_nociception_after2.26549514
12MP0001835_abnormal_antigen_presentation2.20541296
13MP0009785_altered_susceptibility_to2.04084527
14MP0002090_abnormal_vision1.92651875
15MP0000569_abnormal_digit_pigmentation1.87179878
16MP0005645_abnormal_hypothalamus_physiol1.84760636
17MP0002148_abnormal_hypersensitivity_rea1.84591002
18MP0003436_decreased_susceptibility_to1.79082801
19MP0002166_altered_tumor_susceptibility1.76460347
20MP0001873_stomach_inflammation1.71604057
21MP0008872_abnormal_physiological_respon1.68145265
22MP0005084_abnormal_gallbladder_morpholo1.68088095
23MP0006072_abnormal_retinal_apoptosis1.66230605
24MP0008058_abnormal_DNA_repair1.66059153
25MP0003567_abnormal_fetal_cardiomyocyte1.65906906
26MP0008995_early_reproductive_senescence1.60641288
27MP0006035_abnormal_mitochondrial_morpho1.58162111
28MP0001790_abnormal_immune_system1.53717758
29MP0005387_immune_system_phenotype1.53717758
30MP0001905_abnormal_dopamine_level1.51117951
31MP0002006_tumorigenesis1.47248465
32MP0003186_abnormal_redox_activity1.44253266
33MP0005377_hearing/vestibular/ear_phenot1.41922760
34MP0003878_abnormal_ear_physiology1.41922760
35MP0001919_abnormal_reproductive_system1.40219090
36MP0001968_abnormal_touch/_nociception1.40143166
37MP0003718_maternal_effect1.36817206
38MP0003866_abnormal_defecation1.36190188
39MP0002138_abnormal_hepatobiliary_system1.34611701
40MP0005253_abnormal_eye_physiology1.34041576
41MP0000372_irregular_coat_pigmentation1.33836783
42MP0001188_hyperpigmentation1.33330458
43MP0006036_abnormal_mitochondrial_physio1.33038045
44MP0005551_abnormal_eye_electrophysiolog1.32117937
45MP0005000_abnormal_immune_tolerance1.31029269
46MP0005310_abnormal_salivary_gland1.30385996
47MP0002139_abnormal_hepatobiliary_system1.26024730
48MP0004742_abnormal_vestibular_system1.22898732
49MP0005647_abnormal_sex_gland1.21370831
50MP0010094_abnormal_chromosome_stability1.19904403
51MP0010386_abnormal_urinary_bladder1.19765294
52MP0003786_premature_aging1.19471039
53MP0009333_abnormal_splenocyte_physiolog1.18574001
54MP0005646_abnormal_pituitary_gland1.17974580
55MP0005332_abnormal_amino_acid1.16215463
56MP0003011_delayed_dark_adaptation1.14241394
57MP0000371_diluted_coat_color1.13376516
58MP0005636_abnormal_mineral_homeostasis1.13002874
59MP0003787_abnormal_imprinting1.10514767
60MP0005085_abnormal_gallbladder_physiolo1.10479520
61MP0002638_abnormal_pupillary_reflex1.10176931
62MP0002420_abnormal_adaptive_immunity1.08724357
63MP0001819_abnormal_immune_cell1.06260807
64MP0001727_abnormal_embryo_implantation1.04158202
65MP0001501_abnormal_sleep_pattern1.02336031
66MP0003950_abnormal_plasma_membrane1.00247541
67MP0003724_increased_susceptibility_to0.99748183
68MP0001800_abnormal_humoral_immune0.98654158
69MP0005410_abnormal_fertilization0.96690457
70MP0002277_abnormal_respiratory_mucosa0.95036357
71MP0002938_white_spotting0.93350271
72MP0006276_abnormal_autonomic_nervous0.92402451
73MP0009764_decreased_sensitivity_to0.92017920
74MP0002064_seizures0.90937542
75MP0005365_abnormal_bile_salt0.90770803
76MP0002095_abnormal_skin_pigmentation0.90710763
77MP0002723_abnormal_immune_serum0.89707650
78MP0002210_abnormal_sex_determination0.88424537
79MP0005389_reproductive_system_phenotype0.87942614
80MP0000015_abnormal_ear_pigmentation0.86302074
81MP0005075_abnormal_melanosome_morpholog0.85002535
82MP0004957_abnormal_blastocyst_morpholog0.82845974
83MP0004215_abnormal_myocardial_fiber0.82205972
84MP0001984_abnormal_olfaction0.81655461
85MP0009745_abnormal_behavioral_response0.81567348
86MP0003806_abnormal_nucleotide_metabolis0.81389496
87MP0001970_abnormal_pain_threshold0.81339826
88MP0004142_abnormal_muscle_tone0.81313688
89MP0000685_abnormal_immune_system0.80353663
90MP0000358_abnormal_cell_content/0.80145767
91MP0005167_abnormal_blood-brain_barrier0.79350903
92MP0009046_muscle_twitch0.78914169
93MP0010155_abnormal_intestine_physiology0.78832110
94MP0002398_abnormal_bone_marrow0.76428636
95MP0005408_hypopigmentation0.75648217
96MP0009765_abnormal_xenobiotic_induced0.75541931
97MP0002272_abnormal_nervous_system0.74258945
98MP0000490_abnormal_crypts_of0.73781871
99MP0002163_abnormal_gland_morphology0.72728799
100MP0006082_CNS_inflammation0.71914532

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)7.02676512
2Hyperalaninemia (HP:0003348)7.02676512
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.02676512
4Aplastic anemia (HP:0001915)5.00663661
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.92516798
6Testicular atrophy (HP:0000029)4.79744165
7Autoimmune thrombocytopenia (HP:0001973)4.55660431
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.55192903
9Autoimmune hemolytic anemia (HP:0001890)4.27122751
10Visual hallucinations (HP:0002367)4.05498532
11Increased cerebral lipofuscin (HP:0011813)3.95251991
12Dyschromatopsia (HP:0007641)3.57113694
13Methylmalonic acidemia (HP:0002912)3.44474028
14Central scotoma (HP:0000603)3.11753394
15Acute necrotizing encephalopathy (HP:0006965)3.10999696
16Tetraparesis (HP:0002273)3.09167832
173-Methylglutaconic aciduria (HP:0003535)3.08987895
18Increased CSF lactate (HP:0002490)3.02414957
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94325711
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94325711
21Spastic diplegia (HP:0001264)2.90398981
22Abnormality of T cell physiology (HP:0011840)2.88715302
23Methylmalonic aciduria (HP:0012120)2.86207204
24Renal cortical cysts (HP:0000803)2.80446925
25Abnormality of serum amino acid levels (HP:0003112)2.73848951
26Abnormality of midbrain morphology (HP:0002418)2.73260748
27Molar tooth sign on MRI (HP:0002419)2.73260748
28Abnormal mitochondria in muscle tissue (HP:0008316)2.72857335
29Mitochondrial inheritance (HP:0001427)2.71826389
30Abnormality of T cells (HP:0002843)2.69987080
31Hypoproteinemia (HP:0003075)2.65066212
32Cerebral palsy (HP:0100021)2.63651006
33Short tibia (HP:0005736)2.61502605
34Megaloblastic anemia (HP:0001889)2.60499229
35Increased serum lactate (HP:0002151)2.56944126
36Hepatocellular necrosis (HP:0001404)2.55362145
37Progressive macrocephaly (HP:0004481)2.55157333
38Acute encephalopathy (HP:0006846)2.51064694
39Scotoma (HP:0000575)2.48707286
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.41522211
41Prostate neoplasm (HP:0100787)2.34297672
42Opisthotonus (HP:0002179)2.31091843
43Abnormality of the vitamin B12 metabolism (HP:0004341)2.30731490
44Increased serum pyruvate (HP:0003542)2.30504967
45Abnormality of vitamin B metabolism (HP:0004340)2.29969341
46Hepatic necrosis (HP:0002605)2.29432138
47Abnormal albumin level (HP:0012116)2.27237585
48Hypoalbuminemia (HP:0003073)2.27237585
49Gout (HP:0001997)2.23273603
50Abolished electroretinogram (ERG) (HP:0000550)2.20293097
51Lactic acidosis (HP:0003128)2.18927333
52T lymphocytopenia (HP:0005403)2.18479216
53Abnormality of purine metabolism (HP:0004352)2.18345763
54IgG deficiency (HP:0004315)2.17845257
55Cerebral edema (HP:0002181)2.17215802
56Abnormality of the renal cortex (HP:0011035)2.15469614
57Congenital stationary night blindness (HP:0007642)2.10960454
58Abnormality of T cell number (HP:0011839)2.07390615
59Severe combined immunodeficiency (HP:0004430)2.05727753
60Recurrent viral infections (HP:0004429)2.04997895
61Cutaneous melanoma (HP:0012056)2.01949218
62Pancytopenia (HP:0001876)2.01561717
63Lethargy (HP:0001254)2.00791799
64Parakeratosis (HP:0001036)1.94440251
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93378043
66Nephronophthisis (HP:0000090)1.86765527
67Thyroid-stimulating hormone excess (HP:0002925)1.86582398
68Reduced antithrombin III activity (HP:0001976)1.84692092
69Abnormality of glycolysis (HP:0004366)1.84644547
70Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84236788
71Optic disc pallor (HP:0000543)1.80302485
72Oligomenorrhea (HP:0000876)1.79685556
73Respiratory failure (HP:0002878)1.78996999
74Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78201384
75Dicarboxylic aciduria (HP:0003215)1.78201384
76Microvesicular hepatic steatosis (HP:0001414)1.77392012
77Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75942098
78Increased hepatocellular lipid droplets (HP:0006565)1.70854883
79Constricted visual fields (HP:0001133)1.70546286
80Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70416675
81Hypomagnesemia (HP:0002917)1.70088558
82Choreoathetosis (HP:0001266)1.69482731
83Prominent metopic ridge (HP:0005487)1.67322114
84Type I transferrin isoform profile (HP:0003642)1.67043376
85Abnormality of the prostate (HP:0008775)1.65307143
86Poor suck (HP:0002033)1.65002011
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.64584118
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.64233751
89Homocystinuria (HP:0002156)1.64093270
90Abnormality of homocysteine metabolism (HP:0010919)1.64093270
91Chronic bronchitis (HP:0004469)1.63810996
92Abnormality of methionine metabolism (HP:0010901)1.63768461
93Type 2 muscle fiber atrophy (HP:0003554)1.62930217
94Palpitations (HP:0001962)1.62735532
95Microretrognathia (HP:0000308)1.61833084
96Asplenia (HP:0001746)1.61728789
97Hypobetalipoproteinemia (HP:0003563)1.60911712
98Cortical visual impairment (HP:0100704)1.59213511
99Medial flaring of the eyebrow (HP:0010747)1.57824865
100Amniotic constriction ring (HP:0009775)1.57540608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.46825751
2TESK23.96233714
3NEK12.95257486
4ZAK2.83630777
5TXK2.68438726
6TSSK62.27653163
7ADRBK22.22205152
8DAPK22.17423207
9MAP3K122.17106190
10NUAK12.15323686
11MST42.01536183
12INSRR1.99284358
13TLK11.94385195
14BMPR21.91736970
15KDR1.88664914
16BUB11.88332141
17PDK21.80299427
18BCKDK1.78943198
19WNK41.67588418
20PNCK1.63973505
21MAP4K11.61248518
22GRK11.50957850
23TNIK1.45057916
24TAOK31.36645425
25LATS11.32785298
26MYLK1.30031732
27VRK21.29695800
28MAP3K111.29061282
29IKBKB1.20908177
30ACVR1B1.20618045
31TESK11.18404588
32FRK1.17211336
33PRKG21.12838902
34LIMK11.08780227
35STK161.08668799
36TAF11.05709375
37WNK31.04476458
38CHEK21.03404548
39DAPK11.00371217
40VRK10.98585399
41PAK30.93578497
42NME10.93517304
43PASK0.89055502
44WEE10.85425030
45PBK0.84295246
46CAMKK20.83546001
47BMPR1B0.81619087
48FES0.81483783
49DYRK20.81200857
50CAMK2D0.79757201
51TRPM70.75443166
52CDK80.71317564
53CDC70.70677611
54CSNK1A10.67976255
55PHKG10.67480923
56PHKG20.67480923
57TEC0.67426795
58ERBB30.65801271
59PIK3CG0.64333719
60ITK0.63638474
61KIT0.62769059
62EIF2AK30.62605577
63CDK190.60676305
64CSNK1A1L0.59856048
65STK390.59422565
66PLK30.59255615
67AURKA0.59186966
68MAPK130.58755345
69CASK0.58751161
70MAP2K60.58433758
71OXSR10.57472924
72CAMK2A0.57383568
73GRK70.57236703
74EIF2AK10.56939655
75AURKB0.55947987
76LCK0.55462561
77FGFR10.54779711
78CAMK2G0.54677010
79PIM10.54493963
80IKBKE0.54343956
81CSNK2A10.53542732
82GRK60.53044807
83SYK0.51611297
84PRKCQ0.51371642
85TYRO30.49424204
86PRKG10.49270611
87TRIM280.48344161
88RPS6KB10.48032443
89LYN0.47904488
90PRKCE0.47609493
91CSNK1G30.47595144
92STK30.47421012
93BRSK10.47104874
94PRKACA0.46703168
95CSNK2A20.46401290
96CSNK1G20.44746880
97ZAP700.44259994
98OBSCN0.42039709
99MAP2K70.40559881
100PRKCA0.40405970

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.00376856
2Protein export_Homo sapiens_hsa030603.98347940
3Oxidative phosphorylation_Homo sapiens_hsa001903.02072877
4Parkinsons disease_Homo sapiens_hsa050122.64354321
5RNA polymerase_Homo sapiens_hsa030202.34943187
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34153741
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31409220
8Sulfur metabolism_Homo sapiens_hsa009202.06381616
9RNA degradation_Homo sapiens_hsa030182.05582144
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00092302
11Mismatch repair_Homo sapiens_hsa034301.78903033
12Primary immunodeficiency_Homo sapiens_hsa053401.77950095
13Antigen processing and presentation_Homo sapiens_hsa046121.77217213
14Basal transcription factors_Homo sapiens_hsa030221.74396939
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67201654
16Ribosome_Homo sapiens_hsa030101.66769356
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64365586
18Alzheimers disease_Homo sapiens_hsa050101.60090233
19Huntingtons disease_Homo sapiens_hsa050161.59555450
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54875755
21One carbon pool by folate_Homo sapiens_hsa006701.53346797
22Homologous recombination_Homo sapiens_hsa034401.51784122
23Propanoate metabolism_Homo sapiens_hsa006401.51072265
24Pyrimidine metabolism_Homo sapiens_hsa002401.44883963
25Vitamin B6 metabolism_Homo sapiens_hsa007501.42690235
26Folate biosynthesis_Homo sapiens_hsa007901.40695073
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40556438
28Steroid biosynthesis_Homo sapiens_hsa001001.39245052
29Graft-versus-host disease_Homo sapiens_hsa053321.38767675
30Spliceosome_Homo sapiens_hsa030401.38304422
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32473096
32Selenocompound metabolism_Homo sapiens_hsa004501.29945841
33Purine metabolism_Homo sapiens_hsa002301.27344740
34Type I diabetes mellitus_Homo sapiens_hsa049401.26741549
35Butanoate metabolism_Homo sapiens_hsa006501.24674596
36Phototransduction_Homo sapiens_hsa047441.23089854
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18405685
38Regulation of autophagy_Homo sapiens_hsa041401.17111351
39Fanconi anemia pathway_Homo sapiens_hsa034601.16358957
40Nucleotide excision repair_Homo sapiens_hsa034201.15444179
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13423382
42Tryptophan metabolism_Homo sapiens_hsa003801.11511047
43DNA replication_Homo sapiens_hsa030301.11438222
44Base excision repair_Homo sapiens_hsa034101.07977387
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.07405837
46Allograft rejection_Homo sapiens_hsa053301.06213285
47Linoleic acid metabolism_Homo sapiens_hsa005911.02785922
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.01028013
49Asthma_Homo sapiens_hsa053101.00099632
50Cardiac muscle contraction_Homo sapiens_hsa042600.97548684
51Caffeine metabolism_Homo sapiens_hsa002320.96090632
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92628689
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92533154
54RNA transport_Homo sapiens_hsa030130.91725835
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88696365
56Peroxisome_Homo sapiens_hsa041460.87205379
57Autoimmune thyroid disease_Homo sapiens_hsa053200.86684844
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86198507
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83533169
60Chemical carcinogenesis_Homo sapiens_hsa052040.83216051
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79478412
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77647539
63Hematopoietic cell lineage_Homo sapiens_hsa046400.77063224
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74203677
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73634301
66N-Glycan biosynthesis_Homo sapiens_hsa005100.72216786
67mRNA surveillance pathway_Homo sapiens_hsa030150.70453131
68Metabolic pathways_Homo sapiens_hsa011000.69553183
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.69174297
70Retinol metabolism_Homo sapiens_hsa008300.68994242
71Rheumatoid arthritis_Homo sapiens_hsa053230.66670330
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65663638
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65401505
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.64964748
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62384641
76Fatty acid elongation_Homo sapiens_hsa000620.56310908
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.55609668
78Ether lipid metabolism_Homo sapiens_hsa005650.54771371
79Pyruvate metabolism_Homo sapiens_hsa006200.52906042
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51174040
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50079945
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50055542
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.48767439
84Arachidonic acid metabolism_Homo sapiens_hsa005900.48303869
85Circadian rhythm_Homo sapiens_hsa047100.46854563
86Sphingolipid metabolism_Homo sapiens_hsa006000.45033075
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40676890
88Legionellosis_Homo sapiens_hsa051340.40049814
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38980537
90Nitrogen metabolism_Homo sapiens_hsa009100.38878770
91Glutathione metabolism_Homo sapiens_hsa004800.36181370
92Collecting duct acid secretion_Homo sapiens_hsa049660.34686219
93Serotonergic synapse_Homo sapiens_hsa047260.34453350
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34360809
95T cell receptor signaling pathway_Homo sapiens_hsa046600.34002939
96Fat digestion and absorption_Homo sapiens_hsa049750.33418424
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.31434718
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31246624
99ABC transporters_Homo sapiens_hsa020100.30725314
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29286335

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