MRPL38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.37945466
2GDP-mannose metabolic process (GO:0019673)5.10048245
3glycine metabolic process (GO:0006544)4.84284679
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.83052288
5L-phenylalanine metabolic process (GO:0006558)4.83052288
6lysine metabolic process (GO:0006553)4.67181509
7lysine catabolic process (GO:0006554)4.67181509
8regulation of mitochondrial translation (GO:0070129)4.61317559
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.48601041
10L-phenylalanine catabolic process (GO:0006559)4.48601041
11glyoxylate metabolic process (GO:0046487)4.32272524
12protein maturation by protein folding (GO:0022417)4.31343588
13peptidyl-arginine omega-N-methylation (GO:0035247)4.27875058
14serine family amino acid biosynthetic process (GO:0009070)4.24985507
15cysteine metabolic process (GO:0006534)4.17788115
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.14329710
17serine family amino acid catabolic process (GO:0009071)4.13969115
18folic acid-containing compound biosynthetic process (GO:0009396)4.12081774
19serine family amino acid metabolic process (GO:0009069)4.11910055
20kynurenine metabolic process (GO:0070189)3.96439034
21ribosomal small subunit biogenesis (GO:0042274)3.93529922
22aromatic amino acid family catabolic process (GO:0009074)3.91923676
23DNA deamination (GO:0045006)3.88427384
24metallo-sulfur cluster assembly (GO:0031163)3.86669834
25iron-sulfur cluster assembly (GO:0016226)3.86669834
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82141495
27sulfur amino acid catabolic process (GO:0000098)3.74895139
28NADH metabolic process (GO:0006734)3.72899553
29L-serine metabolic process (GO:0006563)3.70376448
30folic acid metabolic process (GO:0046655)3.67992130
31aspartate family amino acid catabolic process (GO:0009068)3.65742864
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63792596
33proteasome assembly (GO:0043248)3.62491805
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60386932
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58714659
36histone arginine methylation (GO:0034969)3.55357218
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54950972
38negative regulation of ligase activity (GO:0051352)3.54950972
39homocysteine metabolic process (GO:0050667)3.52521956
40indole-containing compound catabolic process (GO:0042436)3.51893909
41indolalkylamine catabolic process (GO:0046218)3.51893909
42tryptophan catabolic process (GO:0006569)3.51893909
43urea metabolic process (GO:0019627)3.51837188
44urea cycle (GO:0000050)3.51837188
45amino-acid betaine metabolic process (GO:0006577)3.50866128
462-oxoglutarate metabolic process (GO:0006103)3.50043062
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49893589
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46608824
49regulation of cellular amino acid metabolic process (GO:0006521)3.45599426
50tetrahydrofolate metabolic process (GO:0046653)3.45201049
51protein targeting to mitochondrion (GO:0006626)3.44057635
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.43216462
53alpha-linolenic acid metabolic process (GO:0036109)3.43211239
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42542697
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.42173695
56chaperone-mediated protein transport (GO:0072321)3.40659087
57DNA strand elongation (GO:0022616)3.39261446
58alpha-amino acid catabolic process (GO:1901606)3.38342661
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37570391
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37570391
61negative regulation of fibrinolysis (GO:0051918)3.37558279
62pyrimidine nucleotide catabolic process (GO:0006244)3.37044322
63peptidyl-arginine methylation (GO:0018216)3.36744999
64peptidyl-arginine N-methylation (GO:0035246)3.36744999
65one-carbon metabolic process (GO:0006730)3.36239814
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34452673
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34452673
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34452673
69imidazole-containing compound metabolic process (GO:0052803)3.34414947
70bile acid biosynthetic process (GO:0006699)3.34084509
71pteridine-containing compound biosynthetic process (GO:0042559)3.34034209
72tryptophan metabolic process (GO:0006568)3.33802779
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.33689687
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33689687
75pseudouridine synthesis (GO:0001522)3.33621005
76ATP synthesis coupled proton transport (GO:0015986)3.33455200
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33455200
78telomere maintenance via semi-conservative replication (GO:0032201)3.30283081
79nucleobase-containing small molecule interconversion (GO:0015949)3.29965525
80nitrogen cycle metabolic process (GO:0071941)3.28121025
81establishment of integrated proviral latency (GO:0075713)3.27693768
82ethanol oxidation (GO:0006069)3.24434932
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.24115917
84transcription from mitochondrial promoter (GO:0006390)3.23576305
85oxidative phosphorylation (GO:0006119)3.21434362
86nucleobase biosynthetic process (GO:0046112)3.19901084
87guanosine-containing compound biosynthetic process (GO:1901070)3.19227856
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17676037
89oxaloacetate metabolic process (GO:0006107)3.16860841
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16209153
91tricarboxylic acid cycle (GO:0006099)3.16139573
92cellular amino acid catabolic process (GO:0009063)3.15297754
93rRNA modification (GO:0000154)3.14026231
94regulation of protein activation cascade (GO:2000257)3.12349076
95establishment of viral latency (GO:0019043)3.11744267
96valine metabolic process (GO:0006573)3.11505165
97establishment of protein localization to mitochondrion (GO:0072655)3.11133513
98negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.09718596
99deoxyribose phosphate biosynthetic process (GO:0046385)3.08693378
1002-deoxyribonucleotide biosynthetic process (GO:0009265)3.08693378
101purine nucleobase biosynthetic process (GO:0009113)3.08576228
102rRNA transcription (GO:0009303)3.07740330
103pentose metabolic process (GO:0019321)3.07389437
104pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07201029
105positive regulation of ligase activity (GO:0051351)3.06346596
106ribonucleoprotein complex biogenesis (GO:0022613)3.06334192
107deoxyribonucleotide catabolic process (GO:0009264)3.06259352
108regulation of translational termination (GO:0006449)3.04981617
109respiratory electron transport chain (GO:0022904)3.04552441
110UTP biosynthetic process (GO:0006228)3.04402490
111regulation of translational fidelity (GO:0006450)3.04195521
112pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03860694
113cellular modified amino acid catabolic process (GO:0042219)3.03428602
114ribosome biogenesis (GO:0042254)3.01754207
115formation of translation preinitiation complex (GO:0001731)3.01270936
116aromatic amino acid family metabolic process (GO:0009072)3.01021154
117high-density lipoprotein particle remodeling (GO:0034375)3.00080453
118folic acid-containing compound metabolic process (GO:0006760)2.99943585
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99530349
120regulation of triglyceride catabolic process (GO:0010896)2.99371431
121proline biosynthetic process (GO:0006561)2.99020768
122negative regulation of B cell apoptotic process (GO:0002903)2.97701251
123termination of RNA polymerase III transcription (GO:0006386)2.97259268
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.97259268
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97145576
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97145576
127fatty acid beta-oxidation (GO:0006635)2.96494936
128electron transport chain (GO:0022900)2.96475987
129acetyl-CoA metabolic process (GO:0006084)2.95962256
130aspartate family amino acid metabolic process (GO:0009066)2.95832145
131deoxyribose phosphate catabolic process (GO:0046386)2.95377688
132regulation of fibrinolysis (GO:0051917)2.95100323
133branched-chain amino acid catabolic process (GO:0009083)2.94325811
134tricarboxylic acid metabolic process (GO:0072350)2.94038794
135regulation of complement activation (GO:0030449)2.93744844
136negative regulation of fatty acid biosynthetic process (GO:0045717)2.92978422
137carnitine metabolic process (GO:0009437)2.92519392
138protein localization to mitochondrion (GO:0070585)2.90370013
139negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90198322
140negative regulation of cholesterol transport (GO:0032375)2.89994361
141negative regulation of sterol transport (GO:0032372)2.89994361
142monosaccharide biosynthetic process (GO:0046364)2.89765869
143nuclear envelope reassembly (GO:0031468)2.89581882
144mitotic nuclear envelope reassembly (GO:0007084)2.89581882
145maturation of SSU-rRNA (GO:0030490)2.89074732
146proline metabolic process (GO:0006560)2.88100988
147COPI coating of Golgi vesicle (GO:0048205)2.87857601
148Golgi transport vesicle coating (GO:0048200)2.87857601
149sulfur amino acid biosynthetic process (GO:0000097)2.86045640
150complement activation, alternative pathway (GO:0006957)2.85718255
151regulation of ubiquitin-protein transferase activity (GO:0051438)2.85520234
152pentose-phosphate shunt (GO:0006098)2.85378803
153viral mRNA export from host cell nucleus (GO:0046784)2.83835134
154GTP biosynthetic process (GO:0006183)2.83304629
155ribosomal small subunit assembly (GO:0000028)2.82705420
156peptidyl-histidine modification (GO:0018202)2.82342224
157viral transcription (GO:0019083)2.82161621
158cellular ketone body metabolic process (GO:0046950)2.81650902
159nucleoside salvage (GO:0043174)2.80753966
160positive regulation of cell cycle arrest (GO:0071158)2.80049326
161spliceosomal snRNP assembly (GO:0000387)2.79877416
162rRNA processing (GO:0006364)2.79641953
163gluconeogenesis (GO:0006094)2.79493069
164organic acid catabolic process (GO:0016054)2.79436251
165carboxylic acid catabolic process (GO:0046395)2.79436251
166pteridine-containing compound metabolic process (GO:0042558)2.79237097
167hexose biosynthetic process (GO:0019319)2.78779058
168bile acid metabolic process (GO:0008206)2.78579596
169translational elongation (GO:0006414)2.77813486
170short-chain fatty acid metabolic process (GO:0046459)2.77654160
171branched-chain amino acid metabolic process (GO:0009081)2.77513411
172regulation of ligase activity (GO:0051340)2.77387523
173aldehyde catabolic process (GO:0046185)2.77329863
174DNA strand elongation involved in DNA replication (GO:0006271)2.75542513
175translational termination (GO:0006415)2.75338767
176fatty acid oxidation (GO:0019395)2.75131642
177regulation of cholesterol homeostasis (GO:2000188)2.74754889
178chaperone-mediated protein complex assembly (GO:0051131)2.74532449
179IMP biosynthetic process (GO:0006188)2.73232376
180acylglycerol homeostasis (GO:0055090)2.73214642
181triglyceride homeostasis (GO:0070328)2.73214642
182DNA unwinding involved in DNA replication (GO:0006268)2.72406561
183protein carboxylation (GO:0018214)2.71082209
184peptidyl-glutamic acid carboxylation (GO:0017187)2.71082209
185dicarboxylic acid metabolic process (GO:0043648)2.70031404
186sulfur amino acid metabolic process (GO:0000096)2.69681609
187glutamate metabolic process (GO:0006536)2.68117900
1884-hydroxyproline metabolic process (GO:0019471)2.67455118
189lipid oxidation (GO:0034440)2.67019766
190fatty acid catabolic process (GO:0009062)2.65054000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.95410812
2E2F7_22180533_ChIP-Seq_HELA_Human4.17393769
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95053447
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.63026136
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.59086459
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.21331653
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.13003849
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53570513
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.45012873
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35608514
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35501590
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25863320
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.23917333
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.18636109
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16502617
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.10361901
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05968540
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.02120473
19XRN2_22483619_ChIP-Seq_HELA_Human1.99677968
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96689099
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90418103
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89661598
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.88335420
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.86391620
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86162200
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85230865
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85071332
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82455314
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74441968
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70536075
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67388069
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66998302
33ZNF263_19887448_ChIP-Seq_K562_Human1.66611593
34DCP1A_22483619_ChIP-Seq_HELA_Human1.64399888
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60865789
36GABP_19822575_ChIP-Seq_HepG2_Human1.60706359
37AR_21909140_ChIP-Seq_LNCAP_Human1.59736279
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53324974
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52819975
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48129075
41MYC_22102868_ChIP-Seq_BL_Human1.47703502
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41814042
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41091898
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40629197
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40492218
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.39540831
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38962528
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36382836
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36143233
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36085131
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36036876
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35353556
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34572635
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.34448443
55FOXP3_21729870_ChIP-Seq_TREG_Human1.34132275
56* VDR_23849224_ChIP-Seq_CD4+_Human1.33403370
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33259677
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.31939264
59RACK7_27058665_Chip-Seq_MCF-7_Human1.29331767
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.28841810
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27455092
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24620008
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24413041
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22582910
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21995502
66TTF2_22483619_ChIP-Seq_HELA_Human1.21760528
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21534016
68* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20047760
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19439617
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18979226
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18262723
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18120152
73KDM5A_27292631_Chip-Seq_BREAST_Human1.17778029
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.16335531
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16001273
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15898039
77BCL6_27268052_Chip-Seq_Bcells_Human1.14693196
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14053642
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.13613247
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13586325
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13573596
82CIITA_25753668_ChIP-Seq_RAJI_Human1.12739126
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12583530
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12121964
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11970615
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11801798
87MAF_26560356_Chip-Seq_TH2_Human1.11767870
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09694596
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09616656
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09126798
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08047121
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07500748
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06826411
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06540777
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06536880
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06385041
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.06331526
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06223519
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05817246
100* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05759967
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04921818
102* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04303840
103TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03391928
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03102095
105VDR_21846776_ChIP-Seq_THP-1_Human1.02303243
106RARB_24833708_ChIP-Seq_LIVER_Mouse1.02134511
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01939886
108ATF3_27146783_Chip-Seq_COLON_Human1.01591928
109* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00729538
110CLOCK_20551151_ChIP-Seq_293T_Human1.00487394
111LXR_22292898_ChIP-Seq_THP-1_Human0.96114815
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94993606
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.94268979
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.93491454
115* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93486219
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.91925407
117P68_20966046_ChIP-Seq_HELA_Human0.90214791
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89976149
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88634699
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88393441
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85863989
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.84369103
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84143763
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83983073
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83389338
126PHF8_20622854_ChIP-Seq_HELA_Human0.83115145
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82217088
128BCOR_27268052_Chip-Seq_Bcells_Human0.81959756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.83733260
2MP0005360_urolithiasis5.26623809
3MP0003806_abnormal_nucleotide_metabolis4.92519146
4MP0005085_abnormal_gallbladder_physiolo4.44459446
5MP0005365_abnormal_bile_salt4.11904938
6MP0008875_abnormal_xenobiotic_pharmacok3.09640554
7MP0009840_abnormal_foam_cell2.99987128
8MP0005083_abnormal_biliary_tract2.73864803
9MP0005058_abnormal_lysosome_morphology2.69439917
10MP0008260_abnormal_autophagy2.50603653
11MP0005332_abnormal_amino_acid2.43842806
12MP0003252_abnormal_bile_duct2.37032762
13MP0009333_abnormal_splenocyte_physiolog2.36097649
14MP0010329_abnormal_lipoprotein_level2.30151939
15MP0003693_abnormal_embryo_hatching2.25985548
16MP0004957_abnormal_blastocyst_morpholog2.09771298
17MP0006036_abnormal_mitochondrial_physio2.04822784
18MP0003705_abnormal_hypodermis_morpholog1.90113358
19MP0003186_abnormal_redox_activity1.89233002
20MP0005319_abnormal_enzyme/_coenzyme1.88430507
21MP0003191_abnormal_cellular_cholesterol1.78913914
22MP0001666_abnormal_nutrient_absorption1.78646332
23MP0000609_abnormal_liver_physiology1.76228593
24MP0004185_abnormal_adipocyte_glucose1.70200385
25MP0005670_abnormal_white_adipose1.68417329
26MP0003646_muscle_fatigue1.67810091
27MP0010234_abnormal_vibrissa_follicle1.65867328
28MP0000678_abnormal_parathyroid_gland1.65217642
29MP0002138_abnormal_hepatobiliary_system1.62556876
30MP0003111_abnormal_nucleus_morphology1.62401690
31MP0001661_extended_life_span1.58643784
32MP0003195_calcinosis1.58437847
33MP0001764_abnormal_homeostasis1.55661710
34MP0001873_stomach_inflammation1.46474557
35MP0003077_abnormal_cell_cycle1.45992196
36MP0004019_abnormal_vitamin_homeostasis1.45211997
37MP0009643_abnormal_urine_homeostasis1.43966991
38MP0002837_dystrophic_cardiac_calcinosis1.43930873
39MP0002796_impaired_skin_barrier1.43360913
40MP0004858_abnormal_nervous_system1.42462995
41MP0002269_muscular_atrophy1.39264001
42MP0010094_abnormal_chromosome_stability1.37489423
43MP0002118_abnormal_lipid_homeostasis1.36266559
44MP0000759_abnormal_skeletal_muscle1.35216862
45MP0006035_abnormal_mitochondrial_morpho1.34055520
46MP0005330_cardiomyopathy1.32957793
47MP0000372_irregular_coat_pigmentation1.31592485
48MP0001730_embryonic_growth_arrest1.30674663
49MP0010352_gastrointestinal_tract_polyps1.28808645
50MP0001727_abnormal_embryo_implantation1.28216051
51MP0005266_abnormal_metabolism1.24903733
52MP0004145_abnormal_muscle_electrophysio1.24506961
53MP0003656_abnormal_erythrocyte_physiolo1.23694200
54MP0000598_abnormal_liver_morphology1.23429819
55MP0003763_abnormal_thymus_physiology1.23284198
56MP0000490_abnormal_crypts_of1.22699480
57MP0002877_abnormal_melanocyte_morpholog1.22042070
58MP0003315_abnormal_perineum_morphology1.21485778
59MP0005584_abnormal_enzyme/coenzyme_acti1.19406246
60MP0004084_abnormal_cardiac_muscle1.17427610
61MP0000750_abnormal_muscle_regeneration1.12918858
62MP0000003_abnormal_adipose_tissue1.11017991
63MP0005075_abnormal_melanosome_morpholog1.09598837
64MP0003221_abnormal_cardiomyocyte_apopto1.08517763
65MP0005666_abnormal_adipose_tissue1.07681747
66MP0009278_abnormal_bone_marrow1.05251259
67MP0002249_abnormal_larynx_morphology1.05074171
68MP0001849_ear_inflammation1.02215508
69MP0003172_abnormal_lysosome_physiology1.01646433
70MP0002132_abnormal_respiratory_system1.01487012
71MP0002163_abnormal_gland_morphology1.00534829
72MP0001881_abnormal_mammary_gland0.99464757
73MP0005636_abnormal_mineral_homeostasis0.96334784
74MP0000358_abnormal_cell_content/0.94393261
75MP0000537_abnormal_urethra_morphology0.93518214
76MP0003718_maternal_effect0.92683689
77MP0000703_abnormal_thymus_morphology0.92602387
78MP0000858_altered_metastatic_potential0.92579093
79MP0005380_embryogenesis_phenotype0.88591291
80MP0001672_abnormal_embryogenesis/_devel0.88591291
81MP0003984_embryonic_growth_retardation0.87764803
82MP0010030_abnormal_orbit_morphology0.87587478
83MP0002080_prenatal_lethality0.87367917
84MP0002254_reproductive_system_inflammat0.87254597
85MP0004087_abnormal_muscle_fiber0.87174979
86MP0005451_abnormal_body_composition0.87044838
87MP0008007_abnormal_cellular_replicative0.87036512
88MP0004233_abnormal_muscle_weight0.86288579
89MP0002088_abnormal_embryonic_growth/wei0.86029208
90MP0000749_muscle_degeneration0.85783992
91MP0002396_abnormal_hematopoietic_system0.83970579
92MP0001697_abnormal_embryo_size0.83304465
93MP0005376_homeostasis/metabolism_phenot0.83262732
94MP0008932_abnormal_embryonic_tissue0.83215591
95MP0002429_abnormal_blood_cell0.83026348
96MP0000350_abnormal_cell_proliferation0.82790191
97MP0009697_abnormal_copulation0.82281368
98MP0005384_cellular_phenotype0.80740731
99MP0000681_abnormal_thyroid_gland0.80447036
100MP0001756_abnormal_urination0.80410220
101MP0000733_abnormal_muscle_development0.80296425
102MP0010630_abnormal_cardiac_muscle0.80188015
103MP0002722_abnormal_immune_system0.79888969
104MP0001346_abnormal_lacrimal_gland0.79613189
105MP0001905_abnormal_dopamine_level0.78719678
106MP0005375_adipose_tissue_phenotype0.78150382
107MP0009672_abnormal_birth_weight0.77931468
108MP0002106_abnormal_muscle_physiology0.77373501
109MP0002398_abnormal_bone_marrow0.77210713
110MP0008058_abnormal_DNA_repair0.76448594
111MP0005165_increased_susceptibility_to0.76324026
112MP0005671_abnormal_response_to0.75788256
113MP0003566_abnormal_cell_adhesion0.75358119
114MP0003868_abnormal_feces_composition0.74320522
115MP0001853_heart_inflammation0.74076487
116MP0003567_abnormal_fetal_cardiomyocyte0.72217052
117MP0003123_paternal_imprinting0.72046112
118MP0005220_abnormal_exocrine_pancreas0.71565872
119MP0000747_muscle_weakness0.71029333
120MP0004215_abnormal_myocardial_fiber0.71005796
121MP0008057_abnormal_DNA_replication0.70811318
122MP0005023_abnormal_wound_healing0.70567181
123MP0004197_abnormal_fetal_growth/weight/0.69635954
124MP0000689_abnormal_spleen_morphology0.68283691
125MP0009763_increased_sensitivity_to0.68206268
126MP0003075_altered_response_to0.68109244
127MP0002086_abnormal_extraembryonic_tissu0.67947607
128MP0009053_abnormal_anal_canal0.67672803
129MP0009642_abnormal_blood_homeostasis0.67646441
130MP0004133_heterotaxia0.67005599
131MP0002078_abnormal_glucose_homeostasis0.66894527
132MP0002019_abnormal_tumor_incidence0.66329659
133MP0004130_abnormal_muscle_cell0.65934459
134MP0005647_abnormal_sex_gland0.65733650
135MP0004147_increased_porphyrin_level0.65382591
136MP0000751_myopathy0.64977457
137MP0002970_abnormal_white_adipose0.64788262
138MP0008469_abnormal_protein_level0.64355006
139MP0002653_abnormal_ependyma_morphology0.63516276
140MP0005501_abnormal_skin_physiology0.62978618
141MP0008775_abnormal_heart_ventricle0.62764007
142MP0004036_abnormal_muscle_relaxation0.62014026
143MP0005385_cardiovascular_system_phenoty0.61656011
144MP0001544_abnormal_cardiovascular_syste0.61656011
145MP0000313_abnormal_cell_death0.60891665
146MP0003011_delayed_dark_adaptation0.58954153
147MP0003786_premature_aging0.58841316

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.02096673
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.81717082
3Intrahepatic cholestasis (HP:0001406)4.58003310
4Hypobetalipoproteinemia (HP:0003563)4.55378792
5Hyperammonemia (HP:0001987)4.52501386
6Hyperglycinuria (HP:0003108)4.25820421
7Microvesicular hepatic steatosis (HP:0001414)4.18513142
8Deep venous thrombosis (HP:0002625)4.10363966
9Hyperglycinemia (HP:0002154)3.95288594
10Ketosis (HP:0001946)3.84681952
11Abnormality of glycine metabolism (HP:0010895)3.83586787
12Abnormality of serine family amino acid metabolism (HP:0010894)3.83586787
13Xanthomatosis (HP:0000991)3.79134397
14Abnormal mitochondria in muscle tissue (HP:0008316)3.74220616
15Abnormality of pyrimidine metabolism (HP:0004353)3.71249021
16Hypoglycemic coma (HP:0001325)3.65955173
17Mitochondrial inheritance (HP:0001427)3.54902676
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.47686169
19Dicarboxylic aciduria (HP:0003215)3.47686169
20Abnormality of fatty-acid metabolism (HP:0004359)3.46918659
21Hypolipoproteinemia (HP:0010981)3.35770175
22Acute necrotizing encephalopathy (HP:0006965)3.32550305
23Microretrognathia (HP:0000308)3.31774058
24Rhabdomyolysis (HP:0003201)3.25572028
25Myopathic facies (HP:0002058)3.24570326
26Testicular atrophy (HP:0000029)3.24497962
27Myoglobinuria (HP:0002913)3.22616482
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.22560101
29Ketoacidosis (HP:0001993)3.19314898
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16065070
31Exercise intolerance (HP:0003546)3.09416221
32Abnormality of serum amino acid levels (HP:0003112)3.04574098
33Type I transferrin isoform profile (HP:0003642)3.03313830
34Hepatic necrosis (HP:0002605)3.02374413
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.02328402
36Lethargy (HP:0001254)3.01157193
37Cerebral edema (HP:0002181)2.99332422
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97979374
39Abnormality of methionine metabolism (HP:0010901)2.97376330
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94317613
41Prolonged partial thromboplastin time (HP:0003645)2.92595955
42Multiple enchondromatosis (HP:0005701)2.86498007
43Exercise-induced myalgia (HP:0003738)2.86139736
44Gout (HP:0001997)2.82846914
45Abnormality of nucleobase metabolism (HP:0010932)2.80080217
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.77803746
47Ragged-red muscle fibers (HP:0003200)2.74929977
48Hyperlipoproteinemia (HP:0010980)2.74224514
49Hypoalphalipoproteinemia (HP:0003233)2.73871877
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.73721301
51Abnormal protein N-linked glycosylation (HP:0012347)2.69672080
52Abnormal protein glycosylation (HP:0012346)2.69672080
53Abnormal glycosylation (HP:0012345)2.69672080
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69672080
55Complement deficiency (HP:0004431)2.65384882
56Metabolic acidosis (HP:0001942)2.64704382
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64371563
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64371563
59Late onset (HP:0003584)2.64220055
60Oral leukoplakia (HP:0002745)2.62488898
61Hyperbilirubinemia (HP:0002904)2.60342857
62Nausea (HP:0002018)2.58351543
63Increased muscle lipid content (HP:0009058)2.57025114
64Increased hepatocellular lipid droplets (HP:0006565)2.56335924
65Spastic diplegia (HP:0001264)2.53803610
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53649176
67Generalized aminoaciduria (HP:0002909)2.51680645
68Hepatocellular necrosis (HP:0001404)2.51596799
69Cerebral hypomyelination (HP:0006808)2.51340381
70Delayed CNS myelination (HP:0002188)2.48508003
71Abnormality of cells of the erythroid lineage (HP:0012130)2.46557305
72Nemaline bodies (HP:0003798)2.43441646
73Distal lower limb muscle weakness (HP:0009053)2.43302162
74Increased serum lactate (HP:0002151)2.42724190
75Reduced antithrombin III activity (HP:0001976)2.41455371
76Lactic acidosis (HP:0003128)2.40546853
77Rough bone trabeculation (HP:0100670)2.40515976
78Progressive muscle weakness (HP:0003323)2.39850614
79Muscle fiber inclusion bodies (HP:0100299)2.39163693
80Progressive macrocephaly (HP:0004481)2.38827059
81Abnormal number of erythroid precursors (HP:0012131)2.37990334
82Trismus (HP:0000211)2.36799335
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.35923403
84Abnormality of purine metabolism (HP:0004352)2.34495815
85Hypokinesia (HP:0002375)2.32632159
86Emotional lability (HP:0000712)2.32052121
87Abnormality of the common coagulation pathway (HP:0010990)2.31420093
88Abnormality of the intrinsic pathway (HP:0010989)2.31300209
89Acute encephalopathy (HP:0006846)2.29916440
90Fat malabsorption (HP:0002630)2.28437545
91Cholelithiasis (HP:0001081)2.27363511
92Broad distal phalanx of finger (HP:0009836)2.22377013
93Muscle stiffness (HP:0003552)2.21069942
94Vomiting (HP:0002013)2.20829684
95Respiratory failure (HP:0002878)2.17664183
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17637888
97Abnormal cartilage morphology (HP:0002763)2.17208413
98Seborrheic dermatitis (HP:0001051)2.16551358
99Respiratory difficulties (HP:0002880)2.16473893
100Abnormal gallbladder physiology (HP:0012438)2.16165901
101Cholecystitis (HP:0001082)2.16165901
102Epidermoid cyst (HP:0200040)2.15502823
103Aplastic anemia (HP:0001915)2.14826367
104Neonatal onset (HP:0003623)2.14776897
105Progressive external ophthalmoplegia (HP:0000590)2.12230991
106Hyperuricemia (HP:0002149)2.11738789
107Increased purine levels (HP:0004368)2.11738789
108Proximal tubulopathy (HP:0000114)2.11333833
109Palpitations (HP:0001962)2.11251600
110Progressive microcephaly (HP:0000253)2.11136717
111Abnormality of transition element cation homeostasis (HP:0011030)2.10711143
112Bulbar palsy (HP:0001283)2.09894851
113Hypertensive crisis (HP:0100735)2.09597871
114Abnormality of glycolysis (HP:0004366)2.09391613
115Increased serum pyruvate (HP:0003542)2.09391613
116Abnormality of complement system (HP:0005339)2.08982523
117Renal Fanconi syndrome (HP:0001994)2.08528398
118Increased CSF lactate (HP:0002490)2.07874264
119Abnormality of iron homeostasis (HP:0011031)2.07623208
120CNS demyelination (HP:0007305)2.07600920
121Opisthotonus (HP:0002179)2.06490727
122Increased serum ferritin (HP:0003281)2.05747843
123Abnormal gallbladder morphology (HP:0012437)2.05249234
124Increased intramyocellular lipid droplets (HP:0012240)2.04638244
125Malnutrition (HP:0004395)2.03731762
126Hypercholesterolemia (HP:0003124)2.02052931
127Lipid accumulation in hepatocytes (HP:0006561)2.01370856
128Brushfield spots (HP:0001088)1.98181690
129Hepatocellular carcinoma (HP:0001402)1.96381492
130Right ventricular cardiomyopathy (HP:0011663)1.96001249
131Stridor (HP:0010307)1.94685384
132Distal lower limb amyotrophy (HP:0008944)1.94411865
133Reticulocytopenia (HP:0001896)1.93615089
134Abnormality of reticulocytes (HP:0004312)1.93571213
135Reticulocytosis (HP:0001923)1.93546533
136Achilles tendon contracture (HP:0001771)1.93467283
137Glycosuria (HP:0003076)1.93359243
138Abnormality of urine glucose concentration (HP:0011016)1.93359243
139Secondary amenorrhea (HP:0000869)1.92072595
140Death in infancy (HP:0001522)1.92025797
1413-Methylglutaconic aciduria (HP:0003535)1.91106037
142Megaloblastic anemia (HP:0001889)1.90124341
143Cerebral palsy (HP:0100021)1.90021323
144Methylmalonic aciduria (HP:0012120)1.89485717
145Ventricular tachycardia (HP:0004756)1.89021310
146Abnormality of the gallbladder (HP:0005264)1.88682306
147Abnormality of the Achilles tendon (HP:0005109)1.87836701
148Adenoma sebaceum (HP:0009720)1.86284943
149Angiofibromas (HP:0010615)1.86284943
150Pancytopenia (HP:0001876)1.85831970
151Dysphonia (HP:0001618)1.82152131
152Premature ovarian failure (HP:0008209)1.81620452
153Abnormal trabecular bone morphology (HP:0100671)1.81216457
154Spastic paraparesis (HP:0002313)1.80713277
155Fasciculations (HP:0002380)1.80566698
156Hepatosplenomegaly (HP:0001433)1.79471954
157Gliosis (HP:0002171)1.75819682
158Abnormality of the umbilical cord (HP:0010881)1.75271623
159Generalized amyotrophy (HP:0003700)1.73416592
160Esophageal neoplasm (HP:0100751)1.73411406
161Neoplasm of head and neck (HP:0012288)1.73411406
162Selective tooth agenesis (HP:0001592)1.72606448
163Hyperacusis (HP:0010780)1.71862299
164Paralysis (HP:0003470)1.70159127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.17833009
2VRK24.22395930
3SMG13.15879028
4PKN23.15362744
5ERN12.99578829
6EIF2AK12.89381326
7NEK12.82793677
8TRIB32.69455272
9BUB12.64660081
10WEE12.49955630
11NME22.46822914
12MAP3K112.20820574
13FLT32.07633340
14CDC72.03918901
15MAP3K102.00312671
16PDK31.91697084
17PDK41.91697084
18IRAK31.90522806
19MAP2K31.87808437
20KDR1.85152972
21EPHA21.79960652
22ARAF1.78967371
23SCYL21.74411006
24NEK21.69989463
25EEF2K1.53691912
26FGFR41.53114278
27RPS6KB21.48875148
28TESK21.47806679
29TTK1.40675962
30PBK1.30016324
31SIK11.29065216
32TTN1.28192328
33LIMK11.27675934
34DAPK11.26744819
35LRRK21.24409471
36MAP3K31.24187693
37MAPKAPK31.23339712
38MAP3K81.21630212
39ACVR1B1.21538492
40STK161.20076530
41CDK41.20051594
42PIM21.16450301
43PLK11.14329728
44TSSK61.13660195
45TLK11.13514747
46MAP2K61.13507757
47CDK71.09454729
48PAK41.07113868
49STK38L1.06235573
50EIF2AK31.05671893
51TESK11.05517756
52MAPK111.01191790
53AURKA1.00221694
54AURKB0.99335762
55RPS6KA40.98908777
56TAOK20.98547582
57DYRK30.97468632
58LATS20.90713205
59PTK60.88177662
60BRSK20.84557844
61MAP2K20.83927653
62STK100.82898900
63TGFBR10.82414442
64PASK0.81143605
65PHKG20.80442133
66PHKG10.80442133
67CDK80.79437306
68CDK120.78632447
69ILK0.78582684
70LMTK20.78256088
71ZAK0.76845556
72SRPK10.76428715
73ATR0.74745899
74PRPF4B0.74516629
75CSNK1G30.73371047
76PDK20.72475248
77NME10.72290835
78SIK30.71218689
79ABL20.70300327
80MTOR0.66654048
81MST40.65944073
82PINK10.63751001
83STK40.61693433
84DAPK30.60917690
85CAMK2G0.58896901
86MAP3K50.57473544
87GRK60.56627251
88BRSK10.54267491
89MUSK0.54170493
90BRAF0.53569269
91ICK0.53528402
92VRK10.53294969
93AKT20.52615743
94PRKCI0.51350615
95CSNK2A20.51031372
96PAK10.50854284
97TAOK10.50555121
98CSNK1A1L0.50204145
99OBSCN0.48511832
100RIPK10.47396108
101MAP3K10.46187290
102CHEK10.44550459
103DYRK1B0.44324154
104CCNB10.43988859
105MST1R0.43768754
106CSNK2A10.43492763
107ZAP700.43103422
108RPS6KA50.42043701
109MATK0.41904600
110CDK90.41282205
111MYLK0.40441782
112MAP4K10.39062397
113PIM10.38147852
114TNK20.37902265
115CDK11A0.37592921
116ALK0.36534886
117ERBB40.35936384
118CDK20.35823003
119TBK10.35611283
120TYK20.34653384
121CHEK20.33974528
122CDK140.33163189
123IRAK20.32579326
124CDK60.32427442
125CDK150.31344503
126MAPKAPK20.31061207
127PRKD30.29555705
128MAP3K70.29292912
129PDPK10.29167232
130NEK90.27677980

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25530598
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.85779148
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82034256
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.70166296
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47371731
6Fatty acid degradation_Homo sapiens_hsa000712.38674368
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36656467
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27916398
9Arginine biosynthesis_Homo sapiens_hsa002202.26336595
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25286765
11One carbon pool by folate_Homo sapiens_hsa006702.18189496
12Propanoate metabolism_Homo sapiens_hsa006402.18137247
13Carbon metabolism_Homo sapiens_hsa012002.13842339
14Biosynthesis of amino acids_Homo sapiens_hsa012302.11827672
15DNA replication_Homo sapiens_hsa030302.01025929
16Nitrogen metabolism_Homo sapiens_hsa009101.95964849
17Tryptophan metabolism_Homo sapiens_hsa003801.93778290
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.92895893
19Sulfur relay system_Homo sapiens_hsa041221.90086203
20Pyruvate metabolism_Homo sapiens_hsa006201.89293900
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.82378880
22Selenocompound metabolism_Homo sapiens_hsa004501.82073247
23Ribosome_Homo sapiens_hsa030101.80009045
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.66051265
25Folate biosynthesis_Homo sapiens_hsa007901.61818551
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61675877
27Mismatch repair_Homo sapiens_hsa034301.57313193
28Fatty acid metabolism_Homo sapiens_hsa012121.56521877
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56378202
30Peroxisome_Homo sapiens_hsa041461.56046442
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52556736
32Proteasome_Homo sapiens_hsa030501.52433995
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48507828
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47749548
35Butanoate metabolism_Homo sapiens_hsa006501.45948576
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40449144
37Pentose phosphate pathway_Homo sapiens_hsa000301.39769874
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34812233
39Complement and coagulation cascades_Homo sapiens_hsa046101.34655127
40Other glycan degradation_Homo sapiens_hsa005111.33410602
41PPAR signaling pathway_Homo sapiens_hsa033201.32188421
42beta-Alanine metabolism_Homo sapiens_hsa004101.30247834
43Phenylalanine metabolism_Homo sapiens_hsa003601.26709985
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26625042
45Pyrimidine metabolism_Homo sapiens_hsa002401.19637614
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19439250
47Chemical carcinogenesis_Homo sapiens_hsa052041.15021058
48N-Glycan biosynthesis_Homo sapiens_hsa005101.13289012
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13054354
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12973860
51Non-homologous end-joining_Homo sapiens_hsa034501.11712450
52Arginine and proline metabolism_Homo sapiens_hsa003301.10149950
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06462298
54Fat digestion and absorption_Homo sapiens_hsa049751.06068205
55Caffeine metabolism_Homo sapiens_hsa002321.05646066
56RNA transport_Homo sapiens_hsa030131.05340593
57RNA polymerase_Homo sapiens_hsa030201.03110311
58Glutathione metabolism_Homo sapiens_hsa004801.01715568
59Tyrosine metabolism_Homo sapiens_hsa003500.99581485
60Starch and sucrose metabolism_Homo sapiens_hsa005000.97517748
61Spliceosome_Homo sapiens_hsa030400.94493150
62Base excision repair_Homo sapiens_hsa034100.94087570
63Histidine metabolism_Homo sapiens_hsa003400.92346059
64Nucleotide excision repair_Homo sapiens_hsa034200.84309992
65Fructose and mannose metabolism_Homo sapiens_hsa000510.83644591
66Parkinsons disease_Homo sapiens_hsa050120.82431786
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79879589
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79752654
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79220500
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.79153607
71Primary immunodeficiency_Homo sapiens_hsa053400.78842749
72Bile secretion_Homo sapiens_hsa049760.78757806
73Retinol metabolism_Homo sapiens_hsa008300.77788402
74Galactose metabolism_Homo sapiens_hsa000520.77711165
75Epstein-Barr virus infection_Homo sapiens_hsa051690.73039022
76Lysine degradation_Homo sapiens_hsa003100.72368137
77Fanconi anemia pathway_Homo sapiens_hsa034600.72167270
78Oxidative phosphorylation_Homo sapiens_hsa001900.68597228
79Homologous recombination_Homo sapiens_hsa034400.68157852
80Sulfur metabolism_Homo sapiens_hsa009200.67310281
81Metabolic pathways_Homo sapiens_hsa011000.65054448
82Vibrio cholerae infection_Homo sapiens_hsa051100.64018028
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.63112846
84Vitamin B6 metabolism_Homo sapiens_hsa007500.62392589
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62272360
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60314210
87Huntingtons disease_Homo sapiens_hsa050160.55747932
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54805241
89Fatty acid elongation_Homo sapiens_hsa000620.52816871
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52598525
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52246727
92Glycerolipid metabolism_Homo sapiens_hsa005610.49101598
93Staphylococcus aureus infection_Homo sapiens_hsa051500.45702121
94Vitamin digestion and absorption_Homo sapiens_hsa049770.45080749
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.42167862
96ABC transporters_Homo sapiens_hsa020100.42112534
97Cell cycle_Homo sapiens_hsa041100.41857300
98Purine metabolism_Homo sapiens_hsa002300.40113008
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34932716
100RNA degradation_Homo sapiens_hsa030180.33967062
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33406393
102Herpes simplex infection_Homo sapiens_hsa051680.32413512
103p53 signaling pathway_Homo sapiens_hsa041150.31892988
104Fatty acid biosynthesis_Homo sapiens_hsa000610.31346675
105Viral carcinogenesis_Homo sapiens_hsa052030.30968738
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30366533
107Shigellosis_Homo sapiens_hsa051310.29356014
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29174445
109Systemic lupus erythematosus_Homo sapiens_hsa053220.28875242
110HTLV-I infection_Homo sapiens_hsa051660.28159229
111Bladder cancer_Homo sapiens_hsa052190.28109546
112Alzheimers disease_Homo sapiens_hsa050100.26509815
113Cardiac muscle contraction_Homo sapiens_hsa042600.26443740
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.22546140
115Acute myeloid leukemia_Homo sapiens_hsa052210.22413775
116Apoptosis_Homo sapiens_hsa042100.22380165
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21320984
118Glucagon signaling pathway_Homo sapiens_hsa049220.19354838
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18265117
120Lysosome_Homo sapiens_hsa041420.17251480
121Alcoholism_Homo sapiens_hsa050340.16194768
122Thyroid cancer_Homo sapiens_hsa052160.14385055
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.13636994
124mRNA surveillance pathway_Homo sapiens_hsa030150.12679149
125Oocyte meiosis_Homo sapiens_hsa041140.10493562
126Viral myocarditis_Homo sapiens_hsa054160.09946100
127Basal transcription factors_Homo sapiens_hsa030220.09804337
128Insulin signaling pathway_Homo sapiens_hsa049100.07879518
129Collecting duct acid secretion_Homo sapiens_hsa049660.07750930
130Prion diseases_Homo sapiens_hsa050200.07655469

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