MRPL36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.63446742
2DNA deamination (GO:0045006)6.18904415
3viral transcription (GO:0019083)5.40648496
4translational termination (GO:0006415)5.28027170
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23301834
6ribosomal small subunit biogenesis (GO:0042274)5.19420983
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.11912980
8proteasome assembly (GO:0043248)5.06220572
9cotranslational protein targeting to membrane (GO:0006613)5.05128106
10protein targeting to ER (GO:0045047)5.00038353
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85467227
12ATP synthesis coupled proton transport (GO:0015986)4.85467227
13protein localization to endoplasmic reticulum (GO:0070972)4.81556233
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.72492514
15translational elongation (GO:0006414)4.68947720
16ribosomal large subunit biogenesis (GO:0042273)4.56769293
17maturation of SSU-rRNA (GO:0030490)4.56158833
18telomere maintenance via semi-conservative replication (GO:0032201)4.28123942
19* translation (GO:0006412)4.19943534
20translational initiation (GO:0006413)4.17795179
21viral life cycle (GO:0019058)4.13452573
22cellular protein complex disassembly (GO:0043624)4.12704289
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.08248691
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07985069
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07367261
26DNA strand elongation involved in DNA replication (GO:0006271)4.05591509
27respiratory electron transport chain (GO:0022904)4.02071133
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.01236938
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.01236938
30NADH dehydrogenase complex assembly (GO:0010257)4.01236938
31regulation of mitochondrial translation (GO:0070129)4.01006178
32chaperone-mediated protein transport (GO:0072321)4.00799387
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.99321635
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.95625702
35regulation of cellular amino acid metabolic process (GO:0006521)3.94658022
36electron transport chain (GO:0022900)3.91678370
37respiratory chain complex IV assembly (GO:0008535)3.91353581
38protein complex biogenesis (GO:0070271)3.90600238
39rRNA methylation (GO:0031167)3.90432408
40termination of RNA polymerase III transcription (GO:0006386)3.86340001
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.86340001
42ribonucleoprotein complex biogenesis (GO:0022613)3.86095174
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84600124
44DNA strand elongation (GO:0022616)3.84435416
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78759386
46antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.78400150
47formation of translation preinitiation complex (GO:0001731)3.75282669
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74649284
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71925914
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71925914
51negative regulation of ligase activity (GO:0051352)3.70894421
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70894421
53telomere maintenance via recombination (GO:0000722)3.69331771
54oxidative phosphorylation (GO:0006119)3.68808722
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.68725097
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68725097
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.68725097
58positive regulation of ligase activity (GO:0051351)3.68416261
59pseudouridine synthesis (GO:0001522)3.68342340
60mitochondrial respiratory chain complex assembly (GO:0033108)3.68226200
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66092979
62cellular component biogenesis (GO:0044085)3.64955583
63chromatin remodeling at centromere (GO:0031055)3.63534368
64peptidyl-histidine modification (GO:0018202)3.62477739
65CENP-A containing nucleosome assembly (GO:0034080)3.62124948
66inner mitochondrial membrane organization (GO:0007007)3.58100419
67establishment of integrated proviral latency (GO:0075713)3.57007841
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56343360
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.56343360
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52711702
71protein targeting to mitochondrion (GO:0006626)3.49944439
72protein complex disassembly (GO:0043241)3.49852186
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.49810028
74GTP biosynthetic process (GO:0006183)3.49203311
75nucleobase biosynthetic process (GO:0046112)3.46146755
76cytochrome complex assembly (GO:0017004)3.46026766
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.42753353
787-methylguanosine mRNA capping (GO:0006370)3.41799535
79rRNA processing (GO:0006364)3.40271131
80establishment of protein localization to mitochondrion (GO:0072655)3.39290529
81RNA capping (GO:0036260)3.36771681
827-methylguanosine RNA capping (GO:0009452)3.36771681
83macromolecular complex disassembly (GO:0032984)3.36667055
84purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36508339
85ribosome assembly (GO:0042255)3.35469645
86mitochondrial transport (GO:0006839)3.33662889
87ATP biosynthetic process (GO:0006754)3.33216299
88purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.32996240
89DNA replication initiation (GO:0006270)3.32662055
90regulation of ligase activity (GO:0051340)3.31859054
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.31538915
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28673831
93rRNA modification (GO:0000154)3.28539207
94DNA damage response, detection of DNA damage (GO:0042769)3.27949732
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27612825
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27612825
97maturation of 5.8S rRNA (GO:0000460)3.27328511
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26772275
99guanosine-containing compound biosynthetic process (GO:1901070)3.26037337
100rRNA metabolic process (GO:0016072)3.25447042
101purine nucleobase biosynthetic process (GO:0009113)3.25419998
102protein deneddylation (GO:0000338)3.23995920
103cullin deneddylation (GO:0010388)3.21628672
104UTP biosynthetic process (GO:0006228)3.21431950
105spliceosomal snRNP assembly (GO:0000387)3.21307104
106protein targeting to membrane (GO:0006612)3.21027610
107mitotic recombination (GO:0006312)3.20348154
108hydrogen ion transmembrane transport (GO:1902600)3.17955409
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16215366
110telomere maintenance via telomere lengthening (GO:0010833)3.16059998
111iron-sulfur cluster assembly (GO:0016226)3.14815126
112metallo-sulfur cluster assembly (GO:0031163)3.14815126
113nucleobase-containing small molecule interconversion (GO:0015949)3.14485364
114transcription-coupled nucleotide-excision repair (GO:0006283)3.12907078
115intracellular protein transmembrane import (GO:0044743)3.12840603
116protein neddylation (GO:0045116)3.12529240
117ribosome biogenesis (GO:0042254)3.11796994
118ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10967677
119viral mRNA export from host cell nucleus (GO:0046784)3.10526838
120protein localization to mitochondrion (GO:0070585)3.10354626
121establishment of viral latency (GO:0019043)3.09648568
122nuclear-transcribed mRNA catabolic process (GO:0000956)3.09468793
123regulation of cellular amine metabolic process (GO:0033238)3.09112555
124protein-cofactor linkage (GO:0018065)3.07560340
125transcription from mitochondrial promoter (GO:0006390)3.06962719
126DNA double-strand break processing (GO:0000729)3.05399037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73744521
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57116709
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.29870115
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.29321054
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.17474998
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.00367311
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.98347623
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.59299052
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53639570
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.52154146
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25896124
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16008153
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12471298
14ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12008722
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78192039
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76784471
17VDR_23849224_ChIP-Seq_CD4+_Human2.72123567
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71183853
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63184136
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55584690
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.49399721
22DCP1A_22483619_ChIP-Seq_HELA_Human2.39072624
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38339494
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36621922
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33285691
26XRN2_22483619_ChIP-Seq_HELA_Human2.31488013
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23771287
28FOXP3_21729870_ChIP-Seq_TREG_Human2.22944381
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18747402
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17022445
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10511221
32ELK1_19687146_ChIP-ChIP_HELA_Human2.09771234
33* GABP_19822575_ChIP-Seq_HepG2_Human2.09640050
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07233382
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05860138
36* YY1_21170310_ChIP-Seq_MESCs_Mouse2.02219670
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99405747
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99046427
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97019107
40TTF2_22483619_ChIP-Seq_HELA_Human1.93921902
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78971646
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71887358
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70354798
44* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67924723
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53226655
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48760537
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48010600
48* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45973106
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44790408
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42911518
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42432856
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42369078
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.38167924
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.32639814
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29818801
56SPI1_23547873_ChIP-Seq_NB4_Human1.28767894
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23830516
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22485010
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20457802
60CIITA_25753668_ChIP-Seq_RAJI_Human1.18745438
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13783220
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.13654549
63MYC_18940864_ChIP-ChIP_HL60_Human1.12062359
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11494675
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11428476
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10907003
67AR_21909140_ChIP-Seq_LNCAP_Human1.09768365
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08375854
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07844522
70KDM5A_27292631_Chip-Seq_BREAST_Human1.06885685
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06607279
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05616624
73TFEB_21752829_ChIP-Seq_HELA_Human1.03056126
74CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99923395
75* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99202391
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98406643
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97725694
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97022006
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94518664
80IRF8_22096565_ChIP-ChIP_GC-B_Human0.93534150
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93199402
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92532264
83STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92191966
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91140459
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90054856
86EWS_26573619_Chip-Seq_HEK293_Human0.89810511
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89581573
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89018716
89IRF8_21731497_ChIP-ChIP_J774_Mouse0.87200384
90VDR_22108803_ChIP-Seq_LS180_Human0.86095438
91IRF1_19129219_ChIP-ChIP_H3396_Human0.85718940
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85233923
93ELF5_23300383_ChIP-Seq_T47D_Human0.83695845
94* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83250646
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.82951227
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82567954
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82259309
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79849760
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.79457230
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79132013
101* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79119847
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79029224
103FOXM1_23109430_ChIP-Seq_U2OS_Human0.78142036
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77903229
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77901735
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77831563
107BP1_19119308_ChIP-ChIP_Hs578T_Human0.77638563
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75729464
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.75635758
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75604675
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75591429
112ZNF274_21170338_ChIP-Seq_K562_Hela0.75590966
113TP53_22573176_ChIP-Seq_HFKS_Human0.72874477
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72392347
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.71197662
116FUS_26573619_Chip-Seq_HEK293_Human0.70186416
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.68832796
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.67756531
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67291147
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66878647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.30151458
2MP0009379_abnormal_foot_pigmentation3.84090245
3MP0004957_abnormal_blastocyst_morpholog3.37431550
4MP0002132_abnormal_respiratory_system3.13543065
5MP0003806_abnormal_nucleotide_metabolis3.10523993
6MP0003186_abnormal_redox_activity2.94041367
7MP0006036_abnormal_mitochondrial_physio2.86619303
8MP0010094_abnormal_chromosome_stability2.76329502
9MP0008057_abnormal_DNA_replication2.75887110
10MP0002396_abnormal_hematopoietic_system2.57885788
11MP0008058_abnormal_DNA_repair2.51103996
12MP0003077_abnormal_cell_cycle2.46714721
13MP0001986_abnormal_taste_sensitivity2.46609431
14MP0004147_increased_porphyrin_level2.39247082
15MP0003111_abnormal_nucleus_morphology2.30606028
16MP0002163_abnormal_gland_morphology2.13249470
17MP0001835_abnormal_antigen_presentation2.12481624
18MP0008932_abnormal_embryonic_tissue2.08545986
19MP0009785_altered_susceptibility_to2.01043557
20MP0003763_abnormal_thymus_physiology2.00123302
21MP0006072_abnormal_retinal_apoptosis1.99716721
22MP0002837_dystrophic_cardiac_calcinosis1.97633285
23MP0009333_abnormal_splenocyte_physiolog1.96489878
24MP0000490_abnormal_crypts_of1.96325480
25MP0002148_abnormal_hypersensitivity_rea1.91859066
26MP0006035_abnormal_mitochondrial_morpho1.91272141
27MP0005671_abnormal_response_to1.89660299
28MP0000372_irregular_coat_pigmentation1.80260323
29MP0005075_abnormal_melanosome_morpholog1.79405769
30MP0003724_increased_susceptibility_to1.79176498
31MP0001853_heart_inflammation1.69339010
32MP0005379_endocrine/exocrine_gland_phen1.69299393
33MP0001529_abnormal_vocalization1.64524598
34MP0003718_maternal_effect1.60776814
35MP0008007_abnormal_cellular_replicative1.58412087
36MP0003941_abnormal_skin_development1.57029526
37MP0005025_abnormal_response_to1.53742776
38MP0005174_abnormal_tail_pigmentation1.53693050
39MP0003786_premature_aging1.53448538
40MP0006054_spinal_hemorrhage1.47174473
41MP0005397_hematopoietic_system_phenotyp1.41175334
42MP0001545_abnormal_hematopoietic_system1.41175334
43MP0009697_abnormal_copulation1.39704075
44MP0005000_abnormal_immune_tolerance1.39507710
45MP0003315_abnormal_perineum_morphology1.37039665
46MP0001764_abnormal_homeostasis1.35573699
47MP0002398_abnormal_bone_marrow1.35479942
48MP0003011_delayed_dark_adaptation1.33938078
49MP0000685_abnormal_immune_system1.31355140
50MP0003656_abnormal_erythrocyte_physiolo1.29786677
51MP0002420_abnormal_adaptive_immunity1.29069327
52MP0002736_abnormal_nociception_after1.28846724
53MP0000689_abnormal_spleen_morphology1.28038932
54MP0002722_abnormal_immune_system1.27231465
55MP0002210_abnormal_sex_determination1.27179521
56MP0008789_abnormal_olfactory_epithelium1.26468950
57MP0001819_abnormal_immune_cell1.26130493
58MP0002723_abnormal_immune_serum1.23119131
59MP0008875_abnormal_xenobiotic_pharmacok1.20793888
60MP0001905_abnormal_dopamine_level1.19741696
61MP0002419_abnormal_innate_immunity1.19699945
62MP0002429_abnormal_blood_cell1.19382871
63MP0005410_abnormal_fertilization1.18481502
64MP0005330_cardiomyopathy1.17296368
65MP0002095_abnormal_skin_pigmentation1.16993266
66MP0000716_abnormal_immune_system1.16946252
67MP0002452_abnormal_antigen_presenting1.16642258
68MP0001800_abnormal_humoral_immune1.16260882
69MP0003436_decreased_susceptibility_to1.15087626
70MP0000358_abnormal_cell_content/1.12751485
71MP0001929_abnormal_gametogenesis1.11851926
72MP0001293_anophthalmia1.11355125
73MP0005332_abnormal_amino_acid1.10795815
74MP0008995_early_reproductive_senescence1.10351511
75MP0000015_abnormal_ear_pigmentation1.09804297
76MP0002019_abnormal_tumor_incidence1.09240621
77MP0001984_abnormal_olfaction1.09052012
78MP0000313_abnormal_cell_death1.08210356
79MP0002638_abnormal_pupillary_reflex1.06648719
80MP0000049_abnormal_middle_ear1.06202830
81MP0010030_abnormal_orbit_morphology1.06009098
82MP0003646_muscle_fatigue1.05140393
83MP0005084_abnormal_gallbladder_morpholo1.04402029
84MP0003866_abnormal_defecation1.03454589
85MP0005636_abnormal_mineral_homeostasis1.02224742
86MP0000858_altered_metastatic_potential1.01786005
87MP0005253_abnormal_eye_physiology1.00358511
88MP0008469_abnormal_protein_level1.00116779
89MP0002405_respiratory_system_inflammati0.99232767
90MP0001145_abnormal_male_reproductive0.98920924
91MP0003195_calcinosis0.98404502
92MP0000653_abnormal_sex_gland0.97950209
93MP0003136_yellow_coat_color0.97788918
94MP0002160_abnormal_reproductive_system0.97301449
95MP0004142_abnormal_muscle_tone0.95739091
96MP0000749_muscle_degeneration0.95529796
97MP0000703_abnormal_thymus_morphology0.92723906
98MP0001188_hyperpigmentation0.91621894
99MP0003123_paternal_imprinting0.91567921
100MP0005409_darkened_coat_color0.91273999
101MP0008872_abnormal_physiological_respon0.91187494
102MP0004145_abnormal_muscle_electrophysio0.90137811
103MP0002876_abnormal_thyroid_physiology0.89561896
104MP0001919_abnormal_reproductive_system0.88530994
105MP0002102_abnormal_ear_morphology0.87886172
106MP0002277_abnormal_respiratory_mucosa0.87801591
107MP0005646_abnormal_pituitary_gland0.87022119
108MP0001845_abnormal_inflammatory_respons0.86299930
109MP0001730_embryonic_growth_arrest0.86223842
110MP0001697_abnormal_embryo_size0.85338446
111MP0002938_white_spotting0.85201238
112MP0003567_abnormal_fetal_cardiomyocyte0.84943656
113MP0000631_abnormal_neuroendocrine_gland0.84851859
114MP0009250_abnormal_appendicular_skeleto0.84800503
115MP0004215_abnormal_myocardial_fiber0.83988309
116MP0001542_abnormal_bone_strength0.82601270
117MP0001881_abnormal_mammary_gland0.81009743
118MP0003698_abnormal_male_reproductive0.80998724
119MP0005266_abnormal_metabolism0.80896534
120MP0003937_abnormal_limbs/digits/tail_de0.79583564
121MP0006292_abnormal_olfactory_placode0.79540555
122MP0001790_abnormal_immune_system0.78499725
123MP0005387_immune_system_phenotype0.78499725
124MP0005408_hypopigmentation0.78421463
125MP0000350_abnormal_cell_proliferation0.77270000
126MP0002234_abnormal_pharynx_morphology0.77253752
127MP0004808_abnormal_hematopoietic_stem0.76523586
128MP0005389_reproductive_system_phenotype0.76128061
129MP0010155_abnormal_intestine_physiology0.73906551
130MP0001485_abnormal_pinna_reflex0.73529508
131MP0009046_muscle_twitch0.73500040
132MP0005395_other_phenotype0.73452025
133MP0000465_gastrointestinal_hemorrhage0.72933137
134MP0008877_abnormal_DNA_methylation0.72293013
135MP0001968_abnormal_touch/_nociception0.71919539
136MP0001727_abnormal_embryo_implantation0.70887429
137MP0003221_abnormal_cardiomyocyte_apopto0.69205904
138MP0000681_abnormal_thyroid_gland0.68820349
139MP0008260_abnormal_autophagy0.68444792
140MP0002090_abnormal_vision0.68101947
141MP0005499_abnormal_olfactory_system0.67289506
142MP0005394_taste/olfaction_phenotype0.67289506
143MP0002282_abnormal_trachea_morphology0.67099728
144MP0005551_abnormal_eye_electrophysiolog0.67007151
145MP0002080_prenatal_lethality0.64419380
146MP0005645_abnormal_hypothalamus_physiol0.64299377
147MP0002233_abnormal_nose_morphology0.63393807
148MP0003936_abnormal_reproductive_system0.63016843
149MP0001119_abnormal_female_reproductive0.61711402
150MP0000750_abnormal_muscle_regeneration0.60966976

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.43975558
2Abnormal number of erythroid precursors (HP:0012131)5.24867536
3Acute necrotizing encephalopathy (HP:0006965)5.16153042
4Mitochondrial inheritance (HP:0001427)5.11872045
5Hepatocellular necrosis (HP:0001404)4.92992749
6Abnormal mitochondria in muscle tissue (HP:0008316)4.85139114
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.69964349
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.69964349
9Hepatic necrosis (HP:0002605)4.68012094
10Increased CSF lactate (HP:0002490)4.64702606
11Increased hepatocellular lipid droplets (HP:0006565)4.54774094
12Reticulocytopenia (HP:0001896)4.25950277
13Acute encephalopathy (HP:0006846)4.22008054
14Lipid accumulation in hepatocytes (HP:0006561)4.21990082
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.15861019
16Progressive macrocephaly (HP:0004481)4.11810340
17Renal Fanconi syndrome (HP:0001994)3.92660338
18Increased serum lactate (HP:0002151)3.77356901
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.76175699
203-Methylglutaconic aciduria (HP:0003535)3.75097422
21Type I transferrin isoform profile (HP:0003642)3.72616646
22Increased intramyocellular lipid droplets (HP:0012240)3.63722927
23Exertional dyspnea (HP:0002875)3.61387927
24Aplastic anemia (HP:0001915)3.60419269
25Lactic acidosis (HP:0003128)3.40252177
26Macrocytic anemia (HP:0001972)3.38671709
27Exercise intolerance (HP:0003546)3.24199510
28Increased muscle lipid content (HP:0009058)3.22625958
29Respiratory failure (HP:0002878)3.15389353
30Pallor (HP:0000980)3.12066637
31Abnormality of glycolysis (HP:0004366)3.08330716
32Increased serum pyruvate (HP:0003542)3.08330716
33Respiratory difficulties (HP:0002880)2.95553409
34Cerebral edema (HP:0002181)2.90332814
35Reduced antithrombin III activity (HP:0001976)2.84727952
36Oral leukoplakia (HP:0002745)2.82238997
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77626414
38Abnormal protein N-linked glycosylation (HP:0012347)2.77626414
39Abnormal protein glycosylation (HP:0012346)2.77626414
40Abnormal glycosylation (HP:0012345)2.77626414
41Birth length less than 3rd percentile (HP:0003561)2.74005184
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.69910877
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63805532
44Methylmalonic acidemia (HP:0002912)2.61772365
45Abnormality of alanine metabolism (HP:0010916)2.61360110
46Hyperalaninemia (HP:0003348)2.61360110
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61360110
48Microvesicular hepatic steatosis (HP:0001414)2.59461587
49Cerebral hypomyelination (HP:0006808)2.54463774
50Thrombocytosis (HP:0001894)2.49323219
51Generalized aminoaciduria (HP:0002909)2.48522548
52Abnormality of renal resorption (HP:0011038)2.40774849
53Amniotic constriction ring (HP:0009775)2.39437594
54Abnormality of placental membranes (HP:0011409)2.39437594
55Leukodystrophy (HP:0002415)2.37351266
56Optic disc pallor (HP:0000543)2.37239672
57Poor head control (HP:0002421)2.32951891
58Abnormality of methionine metabolism (HP:0010901)2.32944893
59IgM deficiency (HP:0002850)2.30433552
60CNS demyelination (HP:0007305)2.27183377
61Pancytopenia (HP:0001876)2.26658888
62Abnormality of urine glucose concentration (HP:0011016)2.26644990
63Glycosuria (HP:0003076)2.26644990
64X-linked dominant inheritance (HP:0001423)2.26547235
65Meckel diverticulum (HP:0002245)2.24379143
66Microretrognathia (HP:0000308)2.23669047
67Aplasia/hypoplasia of the uterus (HP:0008684)2.20605034
68Rough bone trabeculation (HP:0100670)2.18426084
69Petechiae (HP:0000967)2.17773571
70Abnormality of the ileum (HP:0001549)2.14722223
71Testicular atrophy (HP:0000029)2.11795547
72Emotional lability (HP:0000712)2.11723285
73Muscle fiber atrophy (HP:0100295)2.10874503
74Nausea (HP:0002018)2.10262493
75Multiple enchondromatosis (HP:0005701)2.04708220
76Abnormality of serum amino acid levels (HP:0003112)2.03591607
7711 pairs of ribs (HP:0000878)2.03122957
78Hyperphosphaturia (HP:0003109)2.02944491
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.02307986
80Sensory axonal neuropathy (HP:0003390)2.01996363
81Congenital, generalized hypertrichosis (HP:0004540)2.00064727
82Breast hypoplasia (HP:0003187)1.98612253
83Type 2 muscle fiber atrophy (HP:0003554)1.98229764
84Premature graying of hair (HP:0002216)1.97453700
85Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93463333
86Colon cancer (HP:0003003)1.93149962
87Carpal bone hypoplasia (HP:0001498)1.91724149
88Lethargy (HP:0001254)1.91633042
89Hyperglycinemia (HP:0002154)1.88187923
90Neutropenia (HP:0001875)1.88111493
91Severe visual impairment (HP:0001141)1.87609273
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85351501
93Ragged-red muscle fibers (HP:0003200)1.84333265
94Elevated erythrocyte sedimentation rate (HP:0003565)1.83778466
95Dicarboxylic aciduria (HP:0003215)1.80221938
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80221938
97Blindness (HP:0000618)1.78818895
98Cleft eyelid (HP:0000625)1.75506013
99Secondary amenorrhea (HP:0000869)1.75023596
100Megaloblastic anemia (HP:0001889)1.72845628
101Hypoplasia of the uterus (HP:0000013)1.71225809
102Gliosis (HP:0002171)1.71006359
103Hypothermia (HP:0002045)1.70367666
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69539875
105Absent thumb (HP:0009777)1.68513835
106Sparse eyelashes (HP:0000653)1.68275257
107Pancreatic cysts (HP:0001737)1.67040709
108Hypoplasia of the pons (HP:0012110)1.66439643
109IgG deficiency (HP:0004315)1.65542938
110Abnormal trabecular bone morphology (HP:0100671)1.65355707
111Methylmalonic aciduria (HP:0012120)1.64871781
112Abnormality of the preputium (HP:0100587)1.63911393
113Abnormality of chromosome stability (HP:0003220)1.63639845
114Recurrent abscess formation (HP:0002722)1.63409290
115Abnormal pupillary function (HP:0007686)1.62774127
116Abnormality of the pons (HP:0007361)1.61131990
117Hypoglycemic coma (HP:0001325)1.60820135
118Bone marrow hypocellularity (HP:0005528)1.59196599
119Palpitations (HP:0001962)1.58703511
120CNS hypomyelination (HP:0003429)1.58186246
121Pulmonary fibrosis (HP:0002206)1.57563383
122Abnormality of the anterior horn cell (HP:0006802)1.57030374
123Degeneration of anterior horn cells (HP:0002398)1.57030374
124Hypoplasia of the radius (HP:0002984)1.57024131
125Progressive muscle weakness (HP:0003323)1.56763880
126Abnormality of reticulocytes (HP:0004312)1.56384102
127Abnormality of T cell physiology (HP:0011840)1.56240784
128Vomiting (HP:0002013)1.55050919
129Triphalangeal thumb (HP:0001199)1.54542014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.96219517
2STK164.36830501
3NME24.29744096
4EIF2AK33.67395396
5BUB13.62558212
6EIF2AK13.54805370
7WEE12.96349597
8PIM22.88351128
9VRK12.58165664
10PDK22.30395802
11NME12.09112829
12NUAK11.88294046
13MAP3K121.85213509
14BRSK21.78957097
15ARAF1.78279427
16TLK11.66169984
17TESK21.65325818
18PBK1.61815773
19SRPK11.61245703
20KDR1.59317326
21ACVR1B1.46242355
22PINK11.43678063
23MAP3K111.43607951
24BCKDK1.43092074
25MST41.42529179
26CDC71.39304722
27TNIK1.38694205
28MKNK11.36887866
29TRIM281.36738660
30TSSK61.36555365
31MAP4K21.34385362
32MYLK1.29836242
33TAF11.29038516
34TEC1.29008650
35PLK41.23977006
36MAP4K11.18642461
37IRAK41.18599072
38BRAF1.14115051
39MKNK21.10184331
40RPS6KA41.06308584
41TXK1.02484710
42CSNK1G11.02152035
43PASK1.01629210
44CDK191.00290767
45ABL21.00210282
46RPS6KB20.99647639
47EIF2AK20.99562487
48CCNB10.98888924
49BLK0.98773045
50SCYL20.94370949
51CDK80.93547240
52CSNK1G20.93393807
53BTK0.93275519
54ZAK0.91921654
55DYRK30.89815033
56WNK30.89671100
57AURKA0.88811366
58CSNK1A1L0.87453629
59ZAP700.85491816
60PLK10.84579326
61IRAK30.84396621
62AURKB0.84046097
63MUSK0.82799477
64BRSK10.80598595
65NEK10.76797284
66CSNK2A10.74838060
67BMPR1B0.73127570
68CHEK20.71947791
69CDK70.71013040
70GRK10.69937254
71KIT0.69579937
72MST1R0.69120825
73MAPKAPK50.68719218
74TESK10.68115195
75CSNK2A20.67937992
76ATR0.67878740
77PIK3CG0.67870103
78OBSCN0.67246590
79MAP2K70.65705186
80PLK20.64830461
81RPS6KA50.63195146
82LYN0.62235867
83SYK0.60194645
84PAK40.59951160
85CLK10.59795347
86IKBKB0.59646776
87FLT30.58909059
88TBK10.58306553
89LIMK10.56346476
90ILK0.55367894
91MAPKAPK30.53719633
92DAPK10.53437407
93MARK30.53361821
94PLK30.52306279
95FRK0.52057513
96MAP2K30.51210832
97PAK10.51071812
98NEK20.50737634
99ADRBK20.46852282
100DYRK20.46195630
101INSRR0.46060447
102CHEK10.45904752
103DAPK30.45840208
104PIM10.45405301
105STK40.44680339
106PRKCI0.43440291
107TYK20.43420695
108IKBKE0.42987957
109RPS6KA60.42892748
110RPS6KC10.41291565
111RPS6KL10.41291565
112PNCK0.40788678
113ATM0.40413855
114STK38L0.40377518
115OXSR10.40010137
116NLK0.39540901
117CSNK1G30.39096549
118ERBB30.38892048
119TGFBR10.38617318
120TTK0.37220602
121LRRK20.36422718
122CAMKK20.35671258
123RAF10.35586699
124YES10.35584949
125MAP3K80.35243229
126CSNK1A10.34659220
127STK240.34094661
128CSNK1E0.32407649
129WNK40.32081191
130PRKCD0.31921969
131STK390.31425944
132MAPK40.30680829
133PHKG10.29586978
134PHKG20.29586978
135PRKCG0.29012709
136GRK50.28651748

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.09995128
2Proteasome_Homo sapiens_hsa030504.64939564
3DNA replication_Homo sapiens_hsa030303.85032662
4Oxidative phosphorylation_Homo sapiens_hsa001903.53208656
5RNA polymerase_Homo sapiens_hsa030203.35810740
6Parkinsons disease_Homo sapiens_hsa050123.21985403
7Protein export_Homo sapiens_hsa030603.19716955
8Mismatch repair_Homo sapiens_hsa034303.12272672
9Pyrimidine metabolism_Homo sapiens_hsa002402.61278629
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43564162
11Homologous recombination_Homo sapiens_hsa034402.40466755
12Huntingtons disease_Homo sapiens_hsa050162.34318051
13Spliceosome_Homo sapiens_hsa030402.28035953
14Base excision repair_Homo sapiens_hsa034102.26870777
15Nucleotide excision repair_Homo sapiens_hsa034202.25621341
16Alzheimers disease_Homo sapiens_hsa050102.13988006
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.00596054
18RNA transport_Homo sapiens_hsa030131.66594219
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66487242
20Basal transcription factors_Homo sapiens_hsa030221.45789233
21Folate biosynthesis_Homo sapiens_hsa007901.44169413
22Non-homologous end-joining_Homo sapiens_hsa034501.42356713
23Purine metabolism_Homo sapiens_hsa002301.42312848
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41775687
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40447180
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33808061
27RNA degradation_Homo sapiens_hsa030181.32845974
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30618583
29Fanconi anemia pathway_Homo sapiens_hsa034601.28058895
30One carbon pool by folate_Homo sapiens_hsa006701.27996814
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14941945
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11195717
33Sulfur relay system_Homo sapiens_hsa041221.07962660
34Pentose phosphate pathway_Homo sapiens_hsa000301.07241740
35Cell cycle_Homo sapiens_hsa041101.05865138
36Cardiac muscle contraction_Homo sapiens_hsa042600.97951104
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93233404
38Glutathione metabolism_Homo sapiens_hsa004800.93154641
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92022092
40N-Glycan biosynthesis_Homo sapiens_hsa005100.82630283
41Vitamin B6 metabolism_Homo sapiens_hsa007500.82364310
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.78051485
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78040320
44Primary immunodeficiency_Homo sapiens_hsa053400.76241652
45Other glycan degradation_Homo sapiens_hsa005110.76204472
46Epstein-Barr virus infection_Homo sapiens_hsa051690.75593744
47Selenocompound metabolism_Homo sapiens_hsa004500.74113261
48Metabolic pathways_Homo sapiens_hsa011000.73986152
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.73160192
50Antigen processing and presentation_Homo sapiens_hsa046120.70766440
51Fatty acid elongation_Homo sapiens_hsa000620.69841002
52Arachidonic acid metabolism_Homo sapiens_hsa005900.68992015
53Sulfur metabolism_Homo sapiens_hsa009200.66828039
54Carbon metabolism_Homo sapiens_hsa012000.66266850
55Steroid biosynthesis_Homo sapiens_hsa001000.63994123
56Allograft rejection_Homo sapiens_hsa053300.62347409
57p53 signaling pathway_Homo sapiens_hsa041150.61871200
58Butanoate metabolism_Homo sapiens_hsa006500.59532133
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59482240
60Legionellosis_Homo sapiens_hsa051340.59410226
61Galactose metabolism_Homo sapiens_hsa000520.58924841
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56955780
63Fructose and mannose metabolism_Homo sapiens_hsa000510.55888786
64Systemic lupus erythematosus_Homo sapiens_hsa053220.51820603
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51766372
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51633335
67Chemical carcinogenesis_Homo sapiens_hsa052040.50984707
68Herpes simplex infection_Homo sapiens_hsa051680.49445713
69Biosynthesis of amino acids_Homo sapiens_hsa012300.49117143
70Asthma_Homo sapiens_hsa053100.47958416
71Pyruvate metabolism_Homo sapiens_hsa006200.46058629
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45308182
73Oocyte meiosis_Homo sapiens_hsa041140.44861861
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44424457
75Graft-versus-host disease_Homo sapiens_hsa053320.43963588
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42904631
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42783655
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41758209
79Vibrio cholerae infection_Homo sapiens_hsa051100.41752125
80Regulation of autophagy_Homo sapiens_hsa041400.40717481
81beta-Alanine metabolism_Homo sapiens_hsa004100.39644174
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.39390742
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36697959
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35958496
85Phototransduction_Homo sapiens_hsa047440.35650897
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34701023
87Peroxisome_Homo sapiens_hsa041460.34612382
88Tryptophan metabolism_Homo sapiens_hsa003800.33616789
89Hematopoietic cell lineage_Homo sapiens_hsa046400.33569746
90Linoleic acid metabolism_Homo sapiens_hsa005910.33492740
91mRNA surveillance pathway_Homo sapiens_hsa030150.33286124
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32135128
93Autoimmune thyroid disease_Homo sapiens_hsa053200.30422097
94Rheumatoid arthritis_Homo sapiens_hsa053230.30410793
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29956871
96Collecting duct acid secretion_Homo sapiens_hsa049660.29491529
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28717196
98Nitrogen metabolism_Homo sapiens_hsa009100.28070706
99Type I diabetes mellitus_Homo sapiens_hsa049400.27841325
100Fatty acid degradation_Homo sapiens_hsa000710.27599624
101Fatty acid metabolism_Homo sapiens_hsa012120.26768197
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25938085
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25731133
104Measles_Homo sapiens_hsa051620.25463358
105Phenylalanine metabolism_Homo sapiens_hsa003600.25428282
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.25236571
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.25209973
108Shigellosis_Homo sapiens_hsa051310.24267093
109Arginine and proline metabolism_Homo sapiens_hsa003300.23942817
110Sphingolipid metabolism_Homo sapiens_hsa006000.23240378
111Renin-angiotensin system_Homo sapiens_hsa046140.23023484
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22888172
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22489628
114Retinol metabolism_Homo sapiens_hsa008300.22224907
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.22130021
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21464724
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20697161
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.19437094
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18965459
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18642856
121Propanoate metabolism_Homo sapiens_hsa006400.18495361
122Arginine biosynthesis_Homo sapiens_hsa002200.16842271
123Phagosome_Homo sapiens_hsa041450.16360095
124Vitamin digestion and absorption_Homo sapiens_hsa049770.16193688
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14692420
126Caffeine metabolism_Homo sapiens_hsa002320.12728928
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12671242
128Tyrosine metabolism_Homo sapiens_hsa003500.12031763
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.10800929
130Viral carcinogenesis_Homo sapiens_hsa052030.10079480

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