MRPL28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitochondrial translation (GO:0070129)9.88707283
2regulation of oxidative phosphorylation (GO:0002082)9.02587513
3DNA double-strand break processing (GO:0000729)8.43384830
4formation of translation preinitiation complex (GO:0001731)7.47127785
5ribosomal small subunit assembly (GO:0000028)5.90856579
6cytochrome complex assembly (GO:0017004)5.84869391
7protein complex biogenesis (GO:0070271)5.76744124
8cellular copper ion homeostasis (GO:0006878)5.61361537
9maturation of SSU-rRNA (GO:0030490)5.54974917
10DNA catabolic process, exonucleolytic (GO:0000738)5.48883243
11mitochondrial respiratory chain complex assembly (GO:0033108)5.35588197
12DNA strand elongation involved in DNA replication (GO:0006271)4.78869927
13proteasome assembly (GO:0043248)4.78002955
14DNA replication checkpoint (GO:0000076)4.68390740
15copper ion homeostasis (GO:0055070)4.62055747
16telomere maintenance via semi-conservative replication (GO:0032201)4.61628029
17ribosomal large subunit biogenesis (GO:0042273)4.61233054
18cullin deneddylation (GO:0010388)4.53694140
19DNA strand elongation (GO:0022616)4.51598544
20protein maturation by protein folding (GO:0022417)4.46896748
21rRNA modification (GO:0000154)4.39111135
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36610994
23viral transcription (GO:0019083)4.28805510
24regulation of skeletal muscle cell differentiation (GO:2001014)4.27428919
25protein deneddylation (GO:0000338)4.19634645
26translational termination (GO:0006415)4.16962070
27copper ion transport (GO:0006825)4.15411734
28postreplication repair (GO:0006301)4.13585786
29negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.09797902
30peptidyl-arginine omega-N-methylation (GO:0035247)4.06065044
31translational initiation (GO:0006413)3.99959169
32nucleobase-containing small molecule interconversion (GO:0015949)3.99679696
33ATP synthesis coupled proton transport (GO:0015986)3.93855970
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93855970
35oxidative phosphorylation (GO:0006119)3.92373217
36proline biosynthetic process (GO:0006561)3.88475088
37telomere maintenance via recombination (GO:0000722)3.88363198
38rRNA methylation (GO:0031167)3.85218255
39ribosomal small subunit biogenesis (GO:0042274)3.80756033
40DNA replication initiation (GO:0006270)3.80574706
41GDP-mannose metabolic process (GO:0019673)3.80458920
42positive regulation of DNA repair (GO:0045739)3.79007785
43nucleobase biosynthetic process (GO:0046112)3.78686587
44regulation of histone H3-K27 methylation (GO:0061085)3.77646490
45translational elongation (GO:0006414)3.76129517
46protein targeting to mitochondrion (GO:0006626)3.72486662
47intra-S DNA damage checkpoint (GO:0031573)3.71889601
48respiratory electron transport chain (GO:0022904)3.71136042
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.71069716
50guanosine-containing compound biosynthetic process (GO:1901070)3.70714978
51establishment of viral latency (GO:0019043)3.70528089
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69813845
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.69606436
54COPI coating of Golgi vesicle (GO:0048205)3.64094610
55Golgi transport vesicle coating (GO:0048200)3.64094610
56cellular component biogenesis (GO:0044085)3.63559051
57cotranslational protein targeting to membrane (GO:0006613)3.63262988
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63086765
59electron transport chain (GO:0022900)3.60984590
60pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.60711950
61protein targeting to ER (GO:0045047)3.60027736
62DNA deamination (GO:0045006)3.58581307
63* translation (GO:0006412)3.57732101
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56571166
65establishment of integrated proviral latency (GO:0075713)3.55198825
66kinetochore assembly (GO:0051382)3.54960494
67prenylation (GO:0097354)3.53812022
68protein prenylation (GO:0018342)3.53812022
69histone arginine methylation (GO:0034969)3.52791400
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.50710672
71nuclear envelope reassembly (GO:0031468)3.49714335
72mitotic nuclear envelope reassembly (GO:0007084)3.49714335
73purine nucleobase biosynthetic process (GO:0009113)3.47121206
74CENP-A containing nucleosome assembly (GO:0034080)3.46723952
75establishment of protein localization to mitochondrion (GO:0072655)3.45636729
76viral mRNA export from host cell nucleus (GO:0046784)3.45588408
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44790790
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42759711
79mitotic recombination (GO:0006312)3.41562381
80transcription elongation from RNA polymerase III promoter (GO:0006385)3.41249430
81termination of RNA polymerase III transcription (GO:0006386)3.41249430
82protein localization to endoplasmic reticulum (GO:0070972)3.40536935
83pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.40394458
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40330144
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.40330144
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.40093644
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.38608974
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37929255
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37557250
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37557250
91chromatin remodeling at centromere (GO:0031055)3.35722999
92regulation of cellular amino acid metabolic process (GO:0006521)3.34443981
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.33896581
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33896581
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33530928
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33530928
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33530928
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31690295
99iron-sulfur cluster assembly (GO:0016226)3.30409841
100metallo-sulfur cluster assembly (GO:0031163)3.30409841
101UTP biosynthetic process (GO:0006228)3.30240403
1022-deoxyribonucleotide biosynthetic process (GO:0009265)3.28863492
103deoxyribose phosphate biosynthetic process (GO:0046385)3.28863492
104pseudouridine synthesis (GO:0001522)3.28352187
105translesion synthesis (GO:0019985)3.26416725
106cellular protein complex disassembly (GO:0043624)3.26318111
107pentose-phosphate shunt (GO:0006098)3.26089435
108signal transduction involved in cell cycle checkpoint (GO:0072395)3.26047209
109viral life cycle (GO:0019058)3.25045271
110CTP biosynthetic process (GO:0006241)3.24910559
111CTP metabolic process (GO:0046036)3.24910559
112purine nucleotide salvage (GO:0032261)3.24434577
1137-methylguanosine mRNA capping (GO:0006370)3.24103750
114protein localization to mitochondrion (GO:0070585)3.23980373
115negative regulation of RNA splicing (GO:0033119)3.22674566
116peptidyl-arginine N-methylation (GO:0035246)3.22120259
117peptidyl-arginine methylation (GO:0018216)3.22120259
118ribonucleoprotein complex biogenesis (GO:0022613)3.21060929
119nucleotide salvage (GO:0043173)3.21034389
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20736986
121negative regulation of ligase activity (GO:0051352)3.20736986
122kinetochore organization (GO:0051383)3.19976711
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19440323
124L-serine metabolic process (GO:0006563)3.18906472
125telomere maintenance via telomere lengthening (GO:0010833)3.18380317
126pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.18316442
127DNA unwinding involved in DNA replication (GO:0006268)3.17348708
128regulation of ubiquitin-protein transferase activity (GO:0051438)3.16199793
129regulation of translational fidelity (GO:0006450)3.15409361
130nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14778888
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13603962
132RNA capping (GO:0036260)3.12900864
1337-methylguanosine RNA capping (GO:0009452)3.12900864
134NADPH regeneration (GO:0006740)3.12018134
135pentose metabolic process (GO:0019321)3.10473145
136maturation of 5.8S rRNA (GO:0000460)3.09292899
137pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.08772100
138GTP biosynthetic process (GO:0006183)3.07458707
139chaperone-mediated protein transport (GO:0072321)3.07104267
140spliceosomal snRNP assembly (GO:0000387)3.06663618
141ribosome biogenesis (GO:0042254)3.06035947
142negative regulation of mRNA processing (GO:0050686)3.05391906
143NADH metabolic process (GO:0006734)3.03839315
144positive regulation of ligase activity (GO:0051351)3.03328011
145negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.03242864
146regulation of ligase activity (GO:0051340)3.03122572
147folic acid metabolic process (GO:0046655)3.02501097
148regulation of mammary gland epithelial cell proliferation (GO:0033599)3.02123759
149deoxyribonucleotide biosynthetic process (GO:0009263)3.00975612
150transcription-coupled nucleotide-excision repair (GO:0006283)3.00609538
151rRNA processing (GO:0006364)2.99099615
152fatty acid homeostasis (GO:0055089)2.99077817
153DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98920271
154glucose catabolic process (GO:0006007)2.96191391
155mitochondrial fusion (GO:0008053)2.93478430
156antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90305660
157nucleoside salvage (GO:0043174)2.90103450
158UTP metabolic process (GO:0046051)2.88049635
159IMP biosynthetic process (GO:0006188)2.85358055
160ribosome assembly (GO:0042255)2.84574435
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.83213427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.22964402
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.24904984
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09722659
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.93837583
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75340980
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.57393293
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.50964785
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.37805094
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.34436433
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.29726236
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10099222
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07190097
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96383800
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86128897
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80047887
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51602048
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41632377
18XRN2_22483619_ChIP-Seq_HELA_Human2.31783081
19VDR_23849224_ChIP-Seq_CD4+_Human2.29883508
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29763288
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29485419
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28950489
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27134814
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22975387
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22777759
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17947231
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.13130959
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12828908
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12828908
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12828908
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10254163
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03224821
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.00249386
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88720116
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.88416058
36* GABP_19822575_ChIP-Seq_HepG2_Human1.87372972
37DCP1A_22483619_ChIP-Seq_HELA_Human1.83705550
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83221978
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.83155202
40ZNF263_19887448_ChIP-Seq_K562_Human1.76316382
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72762525
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64211014
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63956805
44VDR_21846776_ChIP-Seq_THP-1_Human1.62112095
45TTF2_22483619_ChIP-Seq_HELA_Human1.62096545
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60206464
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59606105
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58077306
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57868798
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54832935
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54260470
52AR_21909140_ChIP-Seq_LNCAP_Human1.51594256
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49384615
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48287615
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.47147856
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46910555
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.45542780
58ELK1_19687146_ChIP-ChIP_HELA_Human1.44312256
59* LXR_22292898_ChIP-Seq_THP-1_Human1.44274997
60* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43693050
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43605446
62* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43359402
63CIITA_25753668_ChIP-Seq_RAJI_Human1.42912993
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41199015
65ZNF274_21170338_ChIP-Seq_K562_Hela1.37825566
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36270419
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35765377
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34547583
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32851303
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32850333
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32620829
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31848361
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.28733860
74MYC_18940864_ChIP-ChIP_HL60_Human1.27245514
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26943152
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26399950
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24958660
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23073212
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22566592
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22547333
81* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21621562
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18976690
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17367235
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16639691
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.16572530
86* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16299236
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16247988
88* P68_20966046_ChIP-Seq_HELA_Human1.16197404
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13699380
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13693388
91IGF1R_20145208_ChIP-Seq_DFB_Human1.13502586
92RACK7_27058665_Chip-Seq_MCF-7_Human1.12951651
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12890681
94* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11875287
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.11392306
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10530130
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10050142
98TFEB_21752829_ChIP-Seq_HELA_Human1.08775978
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08089682
100* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05490429
101CTCF_26484167_Chip-Seq_Bcells_Mouse1.04213019
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02750893
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02522825
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01915716
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01437931
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01292170
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01032910
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99327141
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98746718
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.98665076
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95129250
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92472889
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92259821
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.91985527
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.91169708
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89340845
117KDM5A_27292631_Chip-Seq_BREAST_Human0.89219422
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88910343
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87086832
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87014544
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85655461
122VDR_22108803_ChIP-Seq_LS180_Human0.80712070
123MYC_22102868_ChIP-Seq_BL_Human0.79069499
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78983911
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78752796
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78586440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005408_hypopigmentation5.32130321
2MP0002277_abnormal_respiratory_mucosa4.03966708
3MP0009379_abnormal_foot_pigmentation3.60634266
4MP0003693_abnormal_embryo_hatching3.59977001
5MP0010094_abnormal_chromosome_stability3.57842665
6MP0003136_yellow_coat_color3.53125220
7MP0004272_abnormal_basement_membrane3.48424513
8MP0005058_abnormal_lysosome_morphology3.48082003
9MP0005451_abnormal_body_composition3.36275735
10MP0008260_abnormal_autophagy3.23356095
11MP0003077_abnormal_cell_cycle3.12247528
12MP0004957_abnormal_blastocyst_morpholog3.05475732
13MP0003806_abnormal_nucleotide_metabolis2.97134301
14MP0008932_abnormal_embryonic_tissue2.87564530
15MP0008058_abnormal_DNA_repair2.82351946
16MP0008057_abnormal_DNA_replication2.75819393
17MP0002132_abnormal_respiratory_system2.73355065
18MP0002098_abnormal_vibrissa_morphology2.71213099
19MP0003111_abnormal_nucleus_morphology2.37222644
20MP0010030_abnormal_orbit_morphology2.36533641
21MP0006292_abnormal_olfactory_placode2.32354429
22MP0006036_abnormal_mitochondrial_physio2.27552246
23MP0008789_abnormal_olfactory_epithelium2.22783984
24MP0002396_abnormal_hematopoietic_system2.12110627
25MP0000371_diluted_coat_color2.09330933
26MP0001186_pigmentation_phenotype2.06603285
27MP0002877_abnormal_melanocyte_morpholog2.01901767
28MP0003123_paternal_imprinting2.00100102
29MP0003646_muscle_fatigue1.86140668
30MP0001849_ear_inflammation1.83763281
31MP0004233_abnormal_muscle_weight1.81216132
32MP0000462_abnormal_digestive_system1.80261659
33MP0009333_abnormal_splenocyte_physiolog1.74670662
34MP0003186_abnormal_redox_activity1.72262394
35MP0009840_abnormal_foam_cell1.70655426
36MP0001661_extended_life_span1.69505046
37MP0005499_abnormal_olfactory_system1.68275344
38MP0005394_taste/olfaction_phenotype1.68275344
39MP0000566_synostosis1.61829023
40MP0004185_abnormal_adipocyte_glucose1.57643740
41MP0005501_abnormal_skin_physiology1.52931112
42MP0004084_abnormal_cardiac_muscle1.50371382
43MP0003191_abnormal_cellular_cholesterol1.48974135
44MP0000749_muscle_degeneration1.44260079
45MP0003705_abnormal_hypodermis_morpholog1.43815123
46MP0000678_abnormal_parathyroid_gland1.37348525
47MP0008007_abnormal_cellular_replicative1.35641585
48MP0009278_abnormal_bone_marrow1.33188442
49MP0002075_abnormal_coat/hair_pigmentati1.32570515
50MP0001727_abnormal_embryo_implantation1.31429803
51MP0001730_embryonic_growth_arrest1.31120182
52MP0000537_abnormal_urethra_morphology1.30176613
53MP0000372_irregular_coat_pigmentation1.29016109
54MP0005330_cardiomyopathy1.26156870
55MP0004858_abnormal_nervous_system1.25174576
56MP0006072_abnormal_retinal_apoptosis1.24066512
57MP0005623_abnormal_meninges_morphology1.21832814
58MP0000750_abnormal_muscle_regeneration1.20356528
59MP0000350_abnormal_cell_proliferation1.19919768
60MP0003718_maternal_effect1.19525818
61MP0002751_abnormal_autonomic_nervous1.18661496
62MP0005171_absent_coat_pigmentation1.16735751
63MP0002837_dystrophic_cardiac_calcinosis1.14187443
64MP0005636_abnormal_mineral_homeostasis1.14132325
65MP0000858_altered_metastatic_potential1.12614193
66MP0002653_abnormal_ependyma_morphology1.12276667
67MP0004147_increased_porphyrin_level1.11927249
68MP0001697_abnormal_embryo_size1.07918463
69MP0009697_abnormal_copulation1.07614041
70MP0000313_abnormal_cell_death1.07524796
71MP0005384_cellular_phenotype1.07472481
72MP0006035_abnormal_mitochondrial_morpho1.04436812
73MP0003448_altered_tumor_morphology1.03541165
74MP0002282_abnormal_trachea_morphology1.01787924
75MP0005257_abnormal_intraocular_pressure1.01691582
76MP0004036_abnormal_muscle_relaxation0.98540961
77MP0003436_decreased_susceptibility_to0.98020517
78MP0001529_abnormal_vocalization0.97883349
79MP0003315_abnormal_perineum_morphology0.97554272
80MP0004133_heterotaxia0.97352300
81MP0005670_abnormal_white_adipose0.96781561
82MP0010352_gastrointestinal_tract_polyps0.93505717
83MP0005266_abnormal_metabolism0.92286598
84MP0004197_abnormal_fetal_growth/weight/0.91110272
85MP0003890_abnormal_embryonic-extraembry0.90770607
86MP0000343_altered_response_to0.90118570
87MP0002160_abnormal_reproductive_system0.88333650
88MP0000003_abnormal_adipose_tissue0.88235942
89MP0002163_abnormal_gland_morphology0.86292376
90MP0000049_abnormal_middle_ear0.84169251
91MP0002089_abnormal_postnatal_growth/wei0.84120318
92MP0005621_abnormal_cell_physiology0.82946217
93MP0000613_abnormal_salivary_gland0.81414233
94MP0003221_abnormal_cardiomyocyte_apopto0.80250408
95MP0002080_prenatal_lethality0.79156206
96MP0001853_heart_inflammation0.78455584
97MP0002019_abnormal_tumor_incidence0.77338603
98MP0002088_abnormal_embryonic_growth/wei0.76195454
99MP0005584_abnormal_enzyme/coenzyme_acti0.75510868
100MP0002796_impaired_skin_barrier0.75155740
101MP0000681_abnormal_thyroid_gland0.74714654
102MP0000639_abnormal_adrenal_gland0.74392126
103MP0005666_abnormal_adipose_tissue0.73369049
104MP0003137_abnormal_impulse_conducting0.72195827
105MP0005464_abnormal_platelet_physiology0.72164845
106MP0002085_abnormal_embryonic_tissue0.71452915
107MP0003942_abnormal_urinary_system0.70756863
108MP0005023_abnormal_wound_healing0.70007681
109MP0001346_abnormal_lacrimal_gland0.69967555
110MP0002102_abnormal_ear_morphology0.69630238
111MP0003786_premature_aging0.69033301
112MP0005319_abnormal_enzyme/_coenzyme0.68570575
113MP0008995_early_reproductive_senescence0.67765359
114MP0000747_muscle_weakness0.67551230
115MP0000358_abnormal_cell_content/0.66950579
116MP0000490_abnormal_crypts_of0.65767193
117MP0001243_abnormal_dermal_layer0.65398548
118MP0001881_abnormal_mammary_gland0.65017190
119MP0002938_white_spotting0.63800497
120MP0000759_abnormal_skeletal_muscle0.63313566
121MP0002086_abnormal_extraembryonic_tissu0.62026401
122MP0002722_abnormal_immune_system0.61935439
123MP0003453_abnormal_keratinocyte_physiol0.61310076
124MP0005332_abnormal_amino_acid0.61114216
125MP0002269_muscular_atrophy0.60366612
126MP0008873_increased_physiological_sensi0.60261145
127MP0000751_myopathy0.59791846
128MP0004142_abnormal_muscle_tone0.59549191
129MP0003566_abnormal_cell_adhesion0.59035088
130MP0009672_abnormal_birth_weight0.58731046
131MP0000598_abnormal_liver_morphology0.58605789
132MP0002429_abnormal_blood_cell0.58501874
133MP0003941_abnormal_skin_development0.58437844
134MP0005165_increased_susceptibility_to0.57902652
135MP0003121_genomic_imprinting0.57802540
136MP0003329_amyloid_beta_deposits0.57469354
137MP0005397_hematopoietic_system_phenotyp0.57421813
138MP0001545_abnormal_hematopoietic_system0.57421813
139MP0005083_abnormal_biliary_tract0.57363871
140MP0005375_adipose_tissue_phenotype0.56818070
141MP0002254_reproductive_system_inflammat0.56323332
142MP0005248_abnormal_Harderian_gland0.56312516
143MP0002233_abnormal_nose_morphology0.56207066
144MP0005381_digestive/alimentary_phenotyp0.55199428
145MP0001764_abnormal_homeostasis0.54959339
146MP0000685_abnormal_immune_system0.54223241
147MP0002210_abnormal_sex_determination0.54207244
148MP0004215_abnormal_myocardial_fiber0.54000968
149MP0001672_abnormal_embryogenesis/_devel0.52508277
150MP0005380_embryogenesis_phenotype0.52508277
151MP0003828_pulmonary_edema0.52506625
152MP0003984_embryonic_growth_retardation0.52300369
153MP0001145_abnormal_male_reproductive0.51426426
154MP0005085_abnormal_gallbladder_physiolo0.51377499

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.01546529
2Abnormal mitochondria in muscle tissue (HP:0008316)5.52537884
3Acute encephalopathy (HP:0006846)4.97887085
4Aplastic anemia (HP:0001915)4.74298916
5Progressive macrocephaly (HP:0004481)4.72635709
6Abnormality of cells of the erythroid lineage (HP:0012130)4.65458838
7Renal tubular acidosis (HP:0001947)4.62169190
8Mitochondrial inheritance (HP:0001427)4.54569681
9Breast hypoplasia (HP:0003187)4.50970256
10Cholecystitis (HP:0001082)4.36443328
11Abnormal gallbladder physiology (HP:0012438)4.36443328
12Abnormal number of erythroid precursors (HP:0012131)4.35240196
13Colon cancer (HP:0003003)4.18672846
14Increased CSF lactate (HP:0002490)4.14849662
15Microvesicular hepatic steatosis (HP:0001414)3.92393473
16Poor speech (HP:0002465)3.91802207
17Cerebral edema (HP:0002181)3.84504743
18Hepatocellular necrosis (HP:0001404)3.71774879
19Hepatic necrosis (HP:0002605)3.67525251
20Medulloblastoma (HP:0002885)3.66790271
21Ragged-red muscle fibers (HP:0003200)3.57729526
22Reticulocytopenia (HP:0001896)3.37151715
23Exercise intolerance (HP:0003546)3.36545142
24Macrocytic anemia (HP:0001972)3.30634422
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21744315
26Renal tubular dysfunction (HP:0000124)3.20932405
27Abnormality of the fetal cardiovascular system (HP:0010948)3.15365279
28Abnormal umbilical cord blood vessels (HP:0011403)3.15365279
29Single umbilical artery (HP:0001195)3.15365279
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01649463
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01649463
32Cerebral hypomyelination (HP:0006808)2.94590013
33Rough bone trabeculation (HP:0100670)2.93393035
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89053345
35Respiratory failure (HP:0002878)2.88626686
36Optic disc pallor (HP:0000543)2.76877780
37Lactic acidosis (HP:0003128)2.75185587
38Leukodystrophy (HP:0002415)2.73981669
39Multiple enchondromatosis (HP:0005701)2.72964540
40Neuroblastic tumors (HP:0004376)2.72336323
41Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.72336323
42Neuroblastoma (HP:0003006)2.72336323
43Primitive neuroectodermal tumor (HP:0030065)2.72336323
44Microretrognathia (HP:0000308)2.69831582
45Broad distal phalanx of finger (HP:0009836)2.68918751
46Testicular atrophy (HP:0000029)2.64465626
47Increased serum lactate (HP:0002151)2.63860724
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61321633
49Progressive muscle weakness (HP:0003323)2.59607174
50Vertebral compression fractures (HP:0002953)2.58547170
51Agnosia (HP:0010524)2.58418269
52Hypokinesia (HP:0002375)2.58222782
53Increased serum pyruvate (HP:0003542)2.58029376
54Abnormality of glycolysis (HP:0004366)2.58029376
55Myopathic facies (HP:0002058)2.56242036
56Trismus (HP:0000211)2.51772643
57Renal Fanconi syndrome (HP:0001994)2.48905569
58Abnormality of the umbilical cord (HP:0010881)2.48362671
59Achilles tendon contracture (HP:0001771)2.40755397
60Palpitations (HP:0001962)2.39067377
61Cholelithiasis (HP:0001081)2.33486651
62Abnormal glycosylation (HP:0012345)2.31535480
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31535480
64Abnormal protein N-linked glycosylation (HP:0012347)2.31535480
65Abnormal protein glycosylation (HP:0012346)2.31535480
66Pheochromocytoma (HP:0002666)2.31167973
67Exertional dyspnea (HP:0002875)2.31059760
68Hypertensive crisis (HP:0100735)2.28408918
69Neuroendocrine neoplasm (HP:0100634)2.27718098
70Carpal bone hypoplasia (HP:0001498)2.26940208
71Type I transferrin isoform profile (HP:0003642)2.26887915
72Abnormality of the anterior horn cell (HP:0006802)2.24596671
73Degeneration of anterior horn cells (HP:0002398)2.24596671
74Megaloblastic anemia (HP:0001889)2.24279120
75Esophageal neoplasm (HP:0100751)2.23578502
76Neoplasm of head and neck (HP:0012288)2.23578502
77Pallor (HP:0000980)2.20949472
78Neoplasm of the adrenal gland (HP:0100631)2.20194205
79Abnormal trabecular bone morphology (HP:0100671)2.18237874
80Abnormal lung lobation (HP:0002101)2.17012199
81Lethargy (HP:0001254)2.16473659
82Emotional lability (HP:0000712)2.14978879
83Maternal diabetes (HP:0009800)2.14481936
84Opisthotonus (HP:0002179)2.13224633
85Adenoma sebaceum (HP:0009720)2.13134127
86Angiofibromas (HP:0010615)2.13134127
87Abnormality of the Achilles tendon (HP:0005109)2.12955893
88Oral leukoplakia (HP:0002745)2.12175826
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.10719503
90Selective tooth agenesis (HP:0001592)2.10615172
91Increased hepatocellular lipid droplets (HP:0006565)2.10262292
92Petechiae (HP:0000967)2.09218481
93Lipid accumulation in hepatocytes (HP:0006561)2.06387045
94Ependymoma (HP:0002888)2.05982140
95Truncus arteriosus (HP:0001660)2.05693182
96Myoglobinuria (HP:0002913)2.01999011
97Abnormal gallbladder morphology (HP:0012437)2.01155875
98Nausea (HP:0002018)2.00300747
99Abnormality of reticulocytes (HP:0004312)1.99681468
100Secondary amenorrhea (HP:0000869)1.98747336
101Squamous cell carcinoma (HP:0002860)1.98464620
102Neoplasm of the rectum (HP:0100743)1.98178034
103Meckel diverticulum (HP:0002245)1.97012467
104Fasciculations (HP:0002380)1.94815763
105Down-sloping shoulders (HP:0200021)1.94556388
106Hypoplasia of the radius (HP:0002984)1.94270978
107Birth length less than 3rd percentile (HP:0003561)1.93334350
108Hyperacusis (HP:0010780)1.91673206
109Abnormalities of placenta or umbilical cord (HP:0001194)1.90786470
110Increased intramyocellular lipid droplets (HP:0012240)1.90512498
111Death in infancy (HP:0001522)1.90096186
112Prolonged neonatal jaundice (HP:0006579)1.89488679
113Respiratory difficulties (HP:0002880)1.88829626
114Reticulocytosis (HP:0001923)1.88622294
115Metabolic acidosis (HP:0001942)1.88060112
116Progressive external ophthalmoplegia (HP:0000590)1.86475509
117Abnormality of the ileum (HP:0001549)1.86296583
118Generalized aminoaciduria (HP:0002909)1.86227893
119Insomnia (HP:0100785)1.85898666
1203-Methylglutaconic aciduria (HP:0003535)1.84944484
121Entropion (HP:0000621)1.84494787
122Hepatosplenomegaly (HP:0001433)1.83946893
123Abnormality of the gallbladder (HP:0005264)1.83554292
124Unsteady gait (HP:0002317)1.81934644
125Rib fusion (HP:0000902)1.81309860
126Nonimmune hydrops fetalis (HP:0001790)1.81131591
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.80635126
128CNS demyelination (HP:0007305)1.80550486
129Rhabdomyosarcoma (HP:0002859)1.80297127
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79131487
131Dicarboxylic aciduria (HP:0003215)1.79131487
132Hypothermia (HP:0002045)1.78479281
133Progressive neurologic deterioration (HP:0002344)1.77149555
134Abnormality of the septum pellucidum (HP:0007375)1.77057773
135Amaurosis fugax (HP:0100576)1.76317172
136Abnormality of the tricuspid valve (HP:0001702)1.76311315
137Shawl scrotum (HP:0000049)1.76079430
138Calcaneovalgus deformity (HP:0001848)1.76036192
139Increased muscle lipid content (HP:0009058)1.75408812
140Abnormality of the diencephalon (HP:0010662)1.74645981
141Spastic paraparesis (HP:0002313)1.74255191
142High anterior hairline (HP:0009890)1.73437581
143Patellar aplasia (HP:0006443)1.73230022
144Pancytopenia (HP:0001876)1.71994150
145Conjunctival hamartoma (HP:0100780)1.70178915
146Absent septum pellucidum (HP:0001331)1.69875038
147Cortical visual impairment (HP:0100704)1.69781430
148Rhabdomyolysis (HP:0003201)1.69676011
149Ventricular tachycardia (HP:0004756)1.69434646
150Increased serum ferritin (HP:0003281)1.69280970
151Distal upper limb amyotrophy (HP:0007149)1.69182727
152Upper limb amyotrophy (HP:0009129)1.69182727
153Reduced antithrombin III activity (HP:0001976)1.68887537
154Ileus (HP:0002595)1.68245910
155Orthostatic hypotension (HP:0001278)1.66764511
156Septo-optic dysplasia (HP:0100842)1.66059539
157Delusions (HP:0000746)1.65812545
158Abnormality of alanine metabolism (HP:0010916)1.65634627
159Hyperalaninemia (HP:0003348)1.65634627
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65634627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.87286191
2VRK23.68509222
3TLK13.50424880
4TRIB32.64133857
5SMG12.57981124
6ARAF2.52782860
7IRAK32.38569471
8CDK1914.0208492
9BUB11.93159567
10MAP2K31.73235145
11SCYL21.64240367
12CDC71.63407720
13PLK41.58656993
14EPHB21.52866274
15SRPK11.38233131
16STK41.37281451
17STK161.37015156
18PDK21.34328549
19WEE11.26657323
20NME21.21888289
21ICK1.21645768
22ERN11.09229366
23MAP2K61.08331425
24ACVR1B1.07444878
25BRSK20.97630000
26EIF2AK10.96382128
27BCKDK0.92860626
28MYLK0.92311744
29RPS6KA50.87975729
30VRK10.87284909
31CDK80.86060145
32CDK11A0.86007329
33MAP3K30.83494551
34MAPKAPK30.78305361
35PRPF4B0.77356907
36PLK30.77083614
37EEF2K0.74081670
38IRAK10.73558460
39NME10.73535537
40NEK10.73167235
41TSSK60.71750517
42CDK40.69794922
43MAP3K120.67041979
44PRKD30.66775508
45PKN20.65198861
46PHKG20.65044840
47PHKG10.65044840
48EIF2AK30.65040017
49AURKA0.64698074
50AKT20.64330874
51CDK70.63263676
52MKNK10.61509950
53BRSK10.61039432
54MKNK20.60261784
55PLK10.59398574
56MAP2K40.56715069
57CSNK1G30.56708368
58TBK10.55522881
59RAF10.54594999
60CCNB10.54573588
61PAK60.52712593
62MAPK120.52125895
63TESK20.51868242
64DYRK30.51427631
65RPS6KA40.49891154
66TTN0.48571226
67IRAK20.48086071
68MAP2K70.47738824
69ILK0.46941176
70PAK40.46693299
71OBSCN0.46558806
72TESK10.46244029
73ABL20.45887198
74CAMK2G0.45213692
75LIMK10.45137302
76DAPK30.45001016
77CHEK20.44505896
78TTK0.43861333
79BCR0.43544881
80SIK10.42970627
81PBK0.42032226
82ZAK0.41749753
83PASK0.41572377
84PIM20.41170208
85DAPK10.40819079
86TRIM280.38904868
87MAP2K20.38699839
88SIK30.37228468
89MST1R0.36905427
90TGFBR10.36067081
91AURKB0.34461440
92BMX0.33765230
93PDK30.33513152
94PDK40.33513152
95ALK0.33271480
96CDK90.32744327
97CSNK1G10.32509943
98MAPK110.32239219
99CSNK1A1L0.31584388
100LMTK20.31015912
101ATR0.30280226
102BRAF0.29841407
103PRKG20.29436030
104KDR0.28513899
105KSR20.28330410
106MAP3K110.27471847
107LRRK20.27000413
108NEK60.26368150
109MAP3K80.25921636
110CSNK2A10.25188683
111RPS6KB20.23106306
112MAPK40.22020471
113CSNK2A20.21724582
114CDK20.20509125
115PRKCI0.19898447
116GRK70.19813601
117MET0.19658316
118CSNK1G20.18292454
119DYRK20.17645971
120MARK30.17410336
121CASK0.16033737
122PIM10.15942364
123STK38L0.15641261
124AKT30.15306242
125CDK180.14003881
126MAPK90.13940827
127PAK10.13877391
128ATM0.12490356
129MAPK130.12270359
130CDK150.11985988
131CDK140.10127800
132CHEK10.09307731
133CLK10.08883134
134TAOK20.08436668
135EPHA20.06917633
136PRKACG0.06661704
137PRKDC0.06484746

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.17344527
2* Ribosome_Homo sapiens_hsa030103.94192944
3Mismatch repair_Homo sapiens_hsa034303.91806939
4Proteasome_Homo sapiens_hsa030503.62187613
5Renin-angiotensin system_Homo sapiens_hsa046143.34350991
6Oxidative phosphorylation_Homo sapiens_hsa001903.28297526
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.21668972
8Parkinsons disease_Homo sapiens_hsa050123.08453032
9RNA polymerase_Homo sapiens_hsa030202.65393873
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46658669
11Base excision repair_Homo sapiens_hsa034102.30446716
12Pyrimidine metabolism_Homo sapiens_hsa002402.30432270
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.27262503
14Huntingtons disease_Homo sapiens_hsa050162.27115080
15Spliceosome_Homo sapiens_hsa030402.19357674
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16496219
17Homologous recombination_Homo sapiens_hsa034402.15131544
18RNA transport_Homo sapiens_hsa030132.08099253
19African trypanosomiasis_Homo sapiens_hsa051431.99469979
20Alzheimers disease_Homo sapiens_hsa050101.94763428
21Nucleotide excision repair_Homo sapiens_hsa034201.87322773
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84206057
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82657643
24Cardiac muscle contraction_Homo sapiens_hsa042601.65805180
25Sulfur relay system_Homo sapiens_hsa041221.64465877
26beta-Alanine metabolism_Homo sapiens_hsa004101.61085349
27Vitamin B6 metabolism_Homo sapiens_hsa007501.49035388
28Cell cycle_Homo sapiens_hsa041101.46551875
29One carbon pool by folate_Homo sapiens_hsa006701.34570318
30Other glycan degradation_Homo sapiens_hsa005111.27735160
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24385530
32Biosynthesis of amino acids_Homo sapiens_hsa012301.17633627
33N-Glycan biosynthesis_Homo sapiens_hsa005101.16687524
34Mineral absorption_Homo sapiens_hsa049781.15721696
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15089045
36Carbon metabolism_Homo sapiens_hsa012001.14920018
37RNA degradation_Homo sapiens_hsa030181.14737532
38Protein export_Homo sapiens_hsa030601.13431655
39Purine metabolism_Homo sapiens_hsa002301.12164748
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.07314758
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07097651
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04439807
43Systemic lupus erythematosus_Homo sapiens_hsa053221.02887337
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00448731
45Pyruvate metabolism_Homo sapiens_hsa006200.98569673
46Glutathione metabolism_Homo sapiens_hsa004800.97062804
47Non-homologous end-joining_Homo sapiens_hsa034500.93766190
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88173154
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.86830863
50Fanconi anemia pathway_Homo sapiens_hsa034600.86314475
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85575949
52Phenylalanine metabolism_Homo sapiens_hsa003600.84249846
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81118191
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.78704187
55Shigellosis_Homo sapiens_hsa051310.72605831
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.72540619
57Folate biosynthesis_Homo sapiens_hsa007900.70655978
58Synaptic vesicle cycle_Homo sapiens_hsa047210.69676223
59Basal transcription factors_Homo sapiens_hsa030220.68002405
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67714423
61Metabolic pathways_Homo sapiens_hsa011000.66518571
62Bladder cancer_Homo sapiens_hsa052190.65458719
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61930658
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.60401337
65Tyrosine metabolism_Homo sapiens_hsa003500.59200645
66Arginine and proline metabolism_Homo sapiens_hsa003300.57274342
67Arginine biosynthesis_Homo sapiens_hsa002200.57041555
68Fatty acid elongation_Homo sapiens_hsa000620.56943828
69Lysosome_Homo sapiens_hsa041420.55521184
70Fructose and mannose metabolism_Homo sapiens_hsa000510.54707746
71mRNA surveillance pathway_Homo sapiens_hsa030150.53464973
72p53 signaling pathway_Homo sapiens_hsa041150.52846776
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51892344
74Pentose phosphate pathway_Homo sapiens_hsa000300.51276580
75Viral carcinogenesis_Homo sapiens_hsa052030.51251527
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50343276
77Propanoate metabolism_Homo sapiens_hsa006400.48265180
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48233462
79Collecting duct acid secretion_Homo sapiens_hsa049660.47410124
80Selenocompound metabolism_Homo sapiens_hsa004500.47020197
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46482393
82Epstein-Barr virus infection_Homo sapiens_hsa051690.45998607
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43320433
84Steroid biosynthesis_Homo sapiens_hsa001000.42282843
85Fatty acid degradation_Homo sapiens_hsa000710.41587026
86Oocyte meiosis_Homo sapiens_hsa041140.39286968
87Apoptosis_Homo sapiens_hsa042100.36147564
88Sulfur metabolism_Homo sapiens_hsa009200.35522620
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35073159
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32780007
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31752418
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31518886
93Alcoholism_Homo sapiens_hsa050340.31401192
94Arachidonic acid metabolism_Homo sapiens_hsa005900.31262891
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29645561
96Peroxisome_Homo sapiens_hsa041460.28177569
97Salmonella infection_Homo sapiens_hsa051320.27692696
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26804883
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25346734
100Galactose metabolism_Homo sapiens_hsa000520.25151128
101Vibrio cholerae infection_Homo sapiens_hsa051100.24956320
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23618394
103Prion diseases_Homo sapiens_hsa050200.22863384
104Butanoate metabolism_Homo sapiens_hsa006500.21680042
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20563764
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20365882
107Chemical carcinogenesis_Homo sapiens_hsa052040.19148312
108Herpes simplex infection_Homo sapiens_hsa051680.17157830
109HTLV-I infection_Homo sapiens_hsa051660.16761557
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16630073
111Thyroid cancer_Homo sapiens_hsa052160.16590503
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16262304
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16099330
114Acute myeloid leukemia_Homo sapiens_hsa052210.16093030
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14830000
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14673122
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11250104
118Vitamin digestion and absorption_Homo sapiens_hsa049770.10537713
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09460826
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09310026
121Linoleic acid metabolism_Homo sapiens_hsa005910.09230199
122Histidine metabolism_Homo sapiens_hsa003400.06069506
123Fatty acid metabolism_Homo sapiens_hsa012120.05794342
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.05244786
125Tryptophan metabolism_Homo sapiens_hsa003800.04992044

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