MRPL13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.02017198
2central nervous system myelination (GO:0022010)6.02017198
3neuron cell-cell adhesion (GO:0007158)5.85133955
4dopamine biosynthetic process (GO:0042416)5.48041298
5proteasome assembly (GO:0043248)5.45448310
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.21009181
7dopamine transport (GO:0015872)5.17971357
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16576303
9ATP synthesis coupled proton transport (GO:0015986)4.97934101
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.97934101
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.71991200
12establishment of integrated proviral latency (GO:0075713)4.47972510
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.39847867
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.34441252
15CENP-A containing nucleosome assembly (GO:0034080)4.33243564
16chromatin remodeling at centromere (GO:0031055)4.30656564
17presynaptic membrane assembly (GO:0097105)4.30378825
18negative regulation of ligase activity (GO:0051352)4.29177930
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.29177930
20negative regulation of neurotransmitter transport (GO:0051589)4.28203937
21respiratory electron transport chain (GO:0022904)4.28203491
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.24703161
23regulation of dopamine metabolic process (GO:0042053)4.23473990
24regulation of catecholamine metabolic process (GO:0042069)4.23473990
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.19445364
26electron transport chain (GO:0022900)4.17844588
27mitochondrial respiratory chain complex assembly (GO:0033108)4.16663415
28ribosomal large subunit biogenesis (GO:0042273)4.11180466
29rRNA modification (GO:0000154)4.07194700
30regulation of mitochondrial translation (GO:0070129)4.05412200
31fatty acid elongation (GO:0030497)4.02360808
32presynaptic membrane organization (GO:0097090)4.01719267
33ribosomal small subunit assembly (GO:0000028)4.00329030
34regulation of cellular amino acid metabolic process (GO:0006521)3.98187050
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.98056640
36termination of RNA polymerase III transcription (GO:0006386)3.98056640
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.94188566
38NADH dehydrogenase complex assembly (GO:0010257)3.94188566
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94188566
40long-chain fatty acid biosynthetic process (GO:0042759)3.88755929
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.85258292
42transmission of nerve impulse (GO:0019226)3.84049780
43cotranslational protein targeting to membrane (GO:0006613)3.83946552
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79997639
45viral transcription (GO:0019083)3.78175362
46protein targeting to ER (GO:0045047)3.77734819
47translational termination (GO:0006415)3.77332258
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76071105
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76071105
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76071105
51mating behavior (GO:0007617)3.75469907
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.74697700
53chaperone-mediated protein transport (GO:0072321)3.74326502
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74076068
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74076068
56neuron recognition (GO:0008038)3.72348530
57synaptic transmission, dopaminergic (GO:0001963)3.71233009
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71020719
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70789817
60respiratory chain complex IV assembly (GO:0008535)3.68965257
61neuron remodeling (GO:0016322)3.66425334
62protein targeting to mitochondrion (GO:0006626)3.65951611
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63561290
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.63128904
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.63128904
66* translation (GO:0006412)3.63003640
67establishment of viral latency (GO:0019043)3.60367026
68protein neddylation (GO:0045116)3.59436452
69catecholamine transport (GO:0051937)3.59431320
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.58275896
71positive regulation of ligase activity (GO:0051351)3.58019975
72protein localization to endoplasmic reticulum (GO:0070972)3.56750761
73catechol-containing compound biosynthetic process (GO:0009713)3.55536345
74catecholamine biosynthetic process (GO:0042423)3.55536345
75maturation of SSU-rRNA (GO:0030490)3.54873664
76spliceosomal snRNP assembly (GO:0000387)3.53844933
77telomere maintenance via semi-conservative replication (GO:0032201)3.52523277
78positive regulation of synapse assembly (GO:0051965)3.52480748
79oxidative phosphorylation (GO:0006119)3.52275881
80cullin deneddylation (GO:0010388)3.51864930
81substantia nigra development (GO:0021762)3.51575589
82myelination (GO:0042552)3.50512015
83protein localization to mitochondrion (GO:0070585)3.48243838
84histone exchange (GO:0043486)3.46878463
85ensheathment of neurons (GO:0007272)3.44471543
86axon ensheathment (GO:0008366)3.44471543
87ribosomal small subunit biogenesis (GO:0042274)3.44460805
88glycerophospholipid catabolic process (GO:0046475)3.43137664
89cytochrome complex assembly (GO:0017004)3.40966045
90establishment of protein localization to mitochondrion (GO:0072655)3.40026691
91neuronal action potential propagation (GO:0019227)3.39727547
92regulation of ubiquitin-protein transferase activity (GO:0051438)3.39616033
93ionotropic glutamate receptor signaling pathway (GO:0035235)3.38155413
94purine nucleobase biosynthetic process (GO:0009113)3.37246417
95DNA replication checkpoint (GO:0000076)3.36462151
96neurotransmitter catabolic process (GO:0042135)3.36370828
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.36339370
98ATP biosynthetic process (GO:0006754)3.36076800
99translational initiation (GO:0006413)3.34555753
100DNA strand elongation involved in DNA replication (GO:0006271)3.33161706
101protein localization to synapse (GO:0035418)3.32946822
102glutamate receptor signaling pathway (GO:0007215)3.31343137
103rRNA methylation (GO:0031167)3.28460051
104mitotic metaphase plate congression (GO:0007080)3.28345214
105DNA damage response, detection of DNA damage (GO:0042769)3.27841577
106vocalization behavior (GO:0071625)3.27495219
107regulation of ligase activity (GO:0051340)3.27071503
108ribosome assembly (GO:0042255)3.25664051
109translational elongation (GO:0006414)3.25290765
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24228969
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24228969
112DNA replication-independent nucleosome organization (GO:0034724)3.23449005
113DNA replication-independent nucleosome assembly (GO:0006336)3.23449005
114pseudouridine synthesis (GO:0001522)3.22667931
115protein deneddylation (GO:0000338)3.22097290
116regulation of glutamate secretion (GO:0014048)3.21449504
117cellular component biogenesis (GO:0044085)3.19574431
118purine nucleoside triphosphate biosynthetic process (GO:0009145)3.18637310
119DNA strand elongation (GO:0022616)3.17234637
120histone mRNA metabolic process (GO:0008334)3.14030478
121regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13929677
122regulation of mitotic spindle checkpoint (GO:1903504)3.13929677
123DNA double-strand break processing (GO:0000729)3.13001490
124water-soluble vitamin biosynthetic process (GO:0042364)3.11929369
125regulation of vesicle fusion (GO:0031338)3.11634156
126rRNA processing (GO:0006364)3.10773553
127nucleobase biosynthetic process (GO:0046112)3.07924732
128regulation of protein kinase A signaling (GO:0010738)3.07592153
129response to cocaine (GO:0042220)3.03498055
130behavioral response to cocaine (GO:0048148)3.02312899
131negative regulation of protein ubiquitination (GO:0031397)3.01844439
132metaphase plate congression (GO:0051310)3.01521980
133intracellular protein transmembrane import (GO:0044743)3.01202249
134telomere maintenance via recombination (GO:0000722)3.00986955
135phenol-containing compound catabolic process (GO:0019336)3.00833530
136negative regulation of protein localization to cell surface (GO:2000009)3.00128361
137cellular response to epinephrine stimulus (GO:0071872)2.98938654
138positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.97942901
139neuron-neuron synaptic transmission (GO:0007270)2.97304855
140oligodendrocyte differentiation (GO:0048709)2.93677403
141regulation of collateral sprouting (GO:0048670)2.92976014
142postsynaptic membrane organization (GO:0001941)2.90838458
143axonal fasciculation (GO:0007413)2.90198970
144synaptic vesicle exocytosis (GO:0016079)2.88834828
145cholesterol biosynthetic process (GO:0006695)2.87561161
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.86087566
147hydrogen ion transmembrane transport (GO:1902600)2.84834154
148limb bud formation (GO:0060174)2.79401919
149adult walking behavior (GO:0007628)2.77470651
150regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74741299
151GTP biosynthetic process (GO:0006183)2.74672388
152response to epinephrine (GO:0071871)2.72829995
153ATP hydrolysis coupled proton transport (GO:0015991)2.72577169
154energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.72577169
155synaptic transmission, glutamatergic (GO:0035249)2.72157407
156response to redox state (GO:0051775)2.71204092
157exploration behavior (GO:0035640)2.70355755
158negative regulation of neurotransmitter secretion (GO:0046929)2.70094341
159alkaloid metabolic process (GO:0009820)2.69529902
160calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68368493
161negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68087187
162neurotransmitter uptake (GO:0001504)2.66638392
163negative regulation of axon extension (GO:0030517)2.65917292
164locomotory exploration behavior (GO:0035641)2.65494874
165response to histamine (GO:0034776)2.63728520
166proton transport (GO:0015992)2.63445453
167inner mitochondrial membrane organization (GO:0007007)2.63366720
168positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62739642
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62435293
170positive regulation of response to oxidative stress (GO:1902884)2.62025835
171positive regulation of cellular response to oxidative stress (GO:1900409)2.62025835
172dendritic spine morphogenesis (GO:0060997)2.61397889
173dopamine metabolic process (GO:0042417)2.58580474
174neurotransmitter biosynthetic process (GO:0042136)2.58549671
175hydrogen transport (GO:0006818)2.57901016
176neural nucleus development (GO:0048857)2.55098956
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54328894
178regulation of synaptic vesicle exocytosis (GO:2000300)2.51509414
179protein localization to cilium (GO:0061512)2.51411507
180purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.51200566
181regulation of synapse assembly (GO:0051963)2.51012430
182G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50779350
183sterol biosynthetic process (GO:0016126)2.50524026
184synapse assembly (GO:0007416)2.50435102
185histone H2B ubiquitination (GO:0033523)2.49508057
186regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46763801
187protein complex biogenesis (GO:0070271)2.46734737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.68247292
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.85657961
3EZH2_22144423_ChIP-Seq_EOC_Human4.79507092
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.47483380
5E2F7_22180533_ChIP-Seq_HELA_Human4.36480278
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.75988870
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.65518437
8GBX2_23144817_ChIP-Seq_PC3_Human3.56864764
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45175923
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43323644
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.31105263
12TAF15_26573619_Chip-Seq_HEK293_Human3.23950500
13* ETS1_20019798_ChIP-Seq_JURKAT_Human3.19624719
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.17285253
15ELK1_19687146_ChIP-ChIP_HELA_Human3.14350001
16JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03693315
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01330019
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89994119
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87357838
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76051624
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72412025
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65812292
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.63643538
24* VDR_23849224_ChIP-Seq_CD4+_Human2.62018088
25* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.56001189
26* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52926645
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51949352
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51795321
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50013255
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.47728524
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43599986
32EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43599986
33VDR_22108803_ChIP-Seq_LS180_Human2.42419693
34JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42231099
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41756949
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38165524
37FOXP3_21729870_ChIP-Seq_TREG_Human2.38081006
38BMI1_23680149_ChIP-Seq_NPCS_Mouse2.37163733
39MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33750184
40* DCP1A_22483619_ChIP-Seq_HELA_Human2.20473284
41ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19846320
42ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19552251
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19267786
44CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18626199
45CBX2_27304074_Chip-Seq_ESCs_Mouse2.15113142
46MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13684832
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12208045
48SRF_21415370_ChIP-Seq_HL-1_Mouse2.11866973
49SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07287716
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07016113
51EZH2_27294783_Chip-Seq_ESCs_Mouse2.06057179
52THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05906485
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04457533
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03901613
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00889314
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00750876
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00179472
58TTF2_22483619_ChIP-Seq_HELA_Human1.97981282
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97597874
60* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94846958
61AR_21909140_ChIP-Seq_LNCAP_Human1.91916765
62FUS_26573619_Chip-Seq_HEK293_Human1.91141454
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.90815701
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.88398440
65REST_21632747_ChIP-Seq_MESCs_Mouse1.87474053
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84639432
67XRN2_22483619_ChIP-Seq_HELA_Human1.84638351
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79245071
69P300_19829295_ChIP-Seq_ESCs_Human1.77603604
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76769116
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76709454
72GABP_19822575_ChIP-Seq_HepG2_Human1.76455355
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76102288
74IGF1R_20145208_ChIP-Seq_DFB_Human1.73977366
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73562374
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63140089
77MYC_18940864_ChIP-ChIP_HL60_Human1.62291461
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61564204
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61329626
80* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60252611
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.60118321
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59689036
83AR_21572438_ChIP-Seq_LNCaP_Human1.59263705
84ER_23166858_ChIP-Seq_MCF-7_Human1.58157817
85ZNF274_21170338_ChIP-Seq_K562_Hela1.57357776
86RNF2_27304074_Chip-Seq_NSC_Mouse1.56976264
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53999367
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52819238
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50090900
90* E2F1_21310950_ChIP-Seq_MCF-7_Human1.49134174
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46726543
92* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46252304
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.45907881
94SMAD4_21799915_ChIP-Seq_A2780_Human1.44540352
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43904248
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43210980
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41975639
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.40776566
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.40626036
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.38369886
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.37375932
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36014165
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35018621
104* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34525112
105DROSHA_22980978_ChIP-Seq_HELA_Human1.33383768
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29129636
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29096861
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29017679
109* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27335716
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.24927038
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24378523
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.23046466
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21937401
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21790281
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18178894
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17944338
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.15568544
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15067769
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14473890
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14196671
121MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13582353
122RING1B_27294783_Chip-Seq_ESCs_Mouse1.11015378
123RUNX2_22187159_ChIP-Seq_PCA_Human1.10469951
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10030090
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.09846635
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09723110
127NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09278559
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08831174
129JUN_21703547_ChIP-Seq_K562_Human1.08615439
130EWS_26573619_Chip-Seq_HEK293_Human1.07214189
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06693728
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06563609
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.06188722
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.04983674
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.04166416
136TP53_18474530_ChIP-ChIP_U2OS_Human1.02182131
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01904097
138RING1B_27294783_Chip-Seq_NPCs_Mouse1.01567786
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.00185148
140P300_18555785_Chip-Seq_ESCs_Mouse0.99991466
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.99713915
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99428387
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99103580
144KDM5A_27292631_Chip-Seq_BREAST_Human0.98904869
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.98789461
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97991209
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97705797
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97576291
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97044467
150AR_25329375_ChIP-Seq_VCAP_Human0.96745980
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96377394
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94817605
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94566119
154* TAL1_26923725_Chip-Seq_HPCs_Mouse0.94447728
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.94398384
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93983111
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93488143
158P53_22387025_ChIP-Seq_ESCs_Mouse0.92942923
159BCAT_22108803_ChIP-Seq_LS180_Human0.92796889
160E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92374755
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92123403
162KDM2B_26808549_Chip-Seq_REH_Human0.91661724
163FLI1_27457419_Chip-Seq_LIVER_Mouse0.91053632
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90678089
165* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90341910
166* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90341910
167ELF5_23300383_ChIP-Seq_T47D_Human0.87440983
168ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85922436
169PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85400293
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84036672
171RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81497889
172FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78427023
173* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76718848
174IRF1_19129219_ChIP-ChIP_H3396_Human0.75526568
175NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75115747
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75099826
177CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74509023
178SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74105482
179ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73850908
180TP53_22573176_ChIP-Seq_HFKS_Human0.70104024
181HTT_18923047_ChIP-ChIP_STHdh_Human0.69487093
182NOTCH1_21737748_ChIP-Seq_TLL_Human0.68395021
183MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.67698896
184* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.65476298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.83788582
2MP0003806_abnormal_nucleotide_metabolis4.04890169
3MP0008058_abnormal_DNA_repair3.98983959
4MP0010094_abnormal_chromosome_stability3.84908506
5MP0004957_abnormal_blastocyst_morpholog3.84816748
6MP0003693_abnormal_embryo_hatching3.75735852
7MP0001529_abnormal_vocalization3.43986132
8MP0001905_abnormal_dopamine_level3.32456862
9MP0006276_abnormal_autonomic_nervous3.14423702
10MP0003941_abnormal_skin_development2.98603089
11MP0004270_analgesia2.93601891
12MP0004859_abnormal_synaptic_plasticity2.90075478
13MP0003111_abnormal_nucleus_morphology2.87932990
14MP0003077_abnormal_cell_cycle2.87929234
15MP0003718_maternal_effect2.85570013
16MP0003635_abnormal_synaptic_transmissio2.78123916
17MP0009697_abnormal_copulation2.77956815
18MP0009745_abnormal_behavioral_response2.77770329
19MP0002064_seizures2.74688242
20MP0005409_darkened_coat_color2.65685183
21MP0008932_abnormal_embryonic_tissue2.61852256
22MP0005423_abnormal_somatic_nervous2.61704237
23MP0003186_abnormal_redox_activity2.60610779
24MP0001968_abnormal_touch/_nociception2.51283952
25MP0009379_abnormal_foot_pigmentation2.49638745
26MP0002272_abnormal_nervous_system2.47482743
27MP0006036_abnormal_mitochondrial_physio2.43353953
28MP0001486_abnormal_startle_reflex2.41954303
29MP0009046_muscle_twitch2.40943970
30MP0008007_abnormal_cellular_replicative2.35140212
31MP0001440_abnormal_grooming_behavior2.34801819
32MP0002572_abnormal_emotion/affect_behav2.31839596
33MP0003786_premature_aging2.29375116
34MP0000778_abnormal_nervous_system2.25540358
35MP0002736_abnormal_nociception_after2.21810790
36MP0003136_yellow_coat_color2.21547522
37MP0002063_abnormal_learning/memory/cond2.14580982
38MP0000920_abnormal_myelination2.13791066
39MP0006035_abnormal_mitochondrial_morpho2.11792442
40MP0002734_abnormal_mechanical_nocicepti2.07435275
41MP0004142_abnormal_muscle_tone2.03843242
42MP0001501_abnormal_sleep_pattern1.96264884
43MP0004742_abnormal_vestibular_system1.94897322
44MP0008057_abnormal_DNA_replication1.94578331
45MP0005171_absent_coat_pigmentation1.86647269
46MP0002733_abnormal_thermal_nociception1.84174919
47MP0005379_endocrine/exocrine_gland_phen1.84089605
48MP0002735_abnormal_chemical_nociception1.82921795
49MP0002067_abnormal_sensory_capabilities1.78097092
50MP0003329_amyloid_beta_deposits1.77221648
51MP0008877_abnormal_DNA_methylation1.76321279
52MP0001970_abnormal_pain_threshold1.75526370
53MP0001293_anophthalmia1.73794107
54MP0005084_abnormal_gallbladder_morpholo1.73278555
55MP0000372_irregular_coat_pigmentation1.69251890
56MP0002163_abnormal_gland_morphology1.66371258
57MP0004924_abnormal_behavior1.66240274
58MP0005386_behavior/neurological_phenoty1.66240274
59MP0001188_hyperpigmentation1.60656550
60MP0002184_abnormal_innervation1.60338371
61MP0005408_hypopigmentation1.57360657
62MP0002837_dystrophic_cardiac_calcinosis1.49364593
63MP0002557_abnormal_social/conspecific_i1.43015486
64MP0006072_abnormal_retinal_apoptosis1.40469456
65MP0005551_abnormal_eye_electrophysiolog1.40211038
66MP0002882_abnormal_neuron_morphology1.35178082
67MP0008995_early_reproductive_senescence1.34301668
68MP0008875_abnormal_xenobiotic_pharmacok1.33721094
69MP0002822_catalepsy1.33469564
70MP0004147_increased_porphyrin_level1.32193151
71MP0001485_abnormal_pinna_reflex1.31158949
72MP0000955_abnormal_spinal_cord1.30229836
73MP0001764_abnormal_homeostasis1.30210778
74MP0004885_abnormal_endolymph1.27497058
75MP0002066_abnormal_motor_capabilities/c1.25510566
76MP0003690_abnormal_glial_cell1.24730880
77MP0003315_abnormal_perineum_morphology1.22659558
78MP0006292_abnormal_olfactory_placode1.21939378
79MP0010030_abnormal_orbit_morphology1.20234138
80MP0000462_abnormal_digestive_system1.19983505
81MP0003634_abnormal_glial_cell1.19141266
82MP0003567_abnormal_fetal_cardiomyocyte1.19046339
83MP0002752_abnormal_somatic_nervous1.18335143
84MP0002210_abnormal_sex_determination1.17234679
85MP0003122_maternal_imprinting1.17164805
86MP0003938_abnormal_ear_development1.16265480
87MP0003011_delayed_dark_adaptation1.14655929
88MP0004145_abnormal_muscle_electrophysio1.14650515
89MP0002229_neurodegeneration1.14108723
90MP0000358_abnormal_cell_content/1.14006491
91MP0000350_abnormal_cell_proliferation1.12973356
92MP0002160_abnormal_reproductive_system1.10188851
93MP0001697_abnormal_embryo_size1.09799368
94MP0001984_abnormal_olfaction1.08304561
95MP0000631_abnormal_neuroendocrine_gland1.08266499
96MP0001963_abnormal_hearing_physiology1.07155482
97MP0001929_abnormal_gametogenesis1.07102730
98MP0002277_abnormal_respiratory_mucosa1.06954621
99MP0005410_abnormal_fertilization1.06655375
100MP0003890_abnormal_embryonic-extraembry1.06196511
101MP0003632_abnormal_nervous_system1.04483974
102MP0004215_abnormal_myocardial_fiber1.03370513
103MP0001727_abnormal_embryo_implantation1.03366088
104MP0000647_abnormal_sebaceous_gland1.02511323
105MP0001730_embryonic_growth_arrest1.00965360
106MP0001286_abnormal_eye_development0.99550897
107MP0004381_abnormal_hair_follicle0.98530465
108MP0001145_abnormal_male_reproductive0.98449655
109MP0000653_abnormal_sex_gland0.97945720
110MP0002102_abnormal_ear_morphology0.97073888
111MP0000026_abnormal_inner_ear0.96978825
112MP0003937_abnormal_limbs/digits/tail_de0.96707271
113MP0005332_abnormal_amino_acid0.96369652
114MP0001664_abnormal_digestion0.96134566
115MP0002152_abnormal_brain_morphology0.93728252
116MP0003121_genomic_imprinting0.92081791
117MP0005253_abnormal_eye_physiology0.91566725
118MP0008872_abnormal_physiological_respon0.91376209
119MP0003123_paternal_imprinting0.89476657
120MP0005646_abnormal_pituitary_gland0.88165894
121MP0003195_calcinosis0.86576715
122MP0005645_abnormal_hypothalamus_physiol0.85559595
123MP0002085_abnormal_embryonic_tissue0.85384845
124MP0002233_abnormal_nose_morphology0.85274554
125MP0005395_other_phenotype0.84352403
126MP0002282_abnormal_trachea_morphology0.81452445
127MP0005389_reproductive_system_phenotype0.81417540
128MP0008569_lethality_at_weaning0.81248515
129MP0000313_abnormal_cell_death0.81109975
130MP0002751_abnormal_autonomic_nervous0.80947867
131MP0001881_abnormal_mammary_gland0.80502694
132MP0003631_nervous_system_phenotype0.80396789
133MP0002638_abnormal_pupillary_reflex0.79383990
134MP0002080_prenatal_lethality0.78008444
135MP0005195_abnormal_posterior_eye0.77210059
136MP0002697_abnormal_eye_size0.76978076
137MP0003137_abnormal_impulse_conducting0.76417384
138MP0005380_embryogenesis_phenotype0.76410282
139MP0001672_abnormal_embryogenesis/_devel0.76410282
140MP0005499_abnormal_olfactory_system0.75687151
141MP0005394_taste/olfaction_phenotype0.75687151
142MP0004811_abnormal_neuron_physiology0.74457123
143MP0002084_abnormal_developmental_patter0.74284051
144MP0001502_abnormal_circadian_rhythm0.74077436
145MP0005535_abnormal_body_temperature0.73263283
146MP0000604_amyloidosis0.72597534
147MP0005085_abnormal_gallbladder_physiolo0.72239401
148MP0008789_abnormal_olfactory_epithelium0.71784855
149MP0002876_abnormal_thyroid_physiology0.71687645
150MP0005636_abnormal_mineral_homeostasis0.71351979
151MP0002111_abnormal_tail_morphology0.71149319
152MP0003119_abnormal_digestive_system0.70987158
153MP0001119_abnormal_female_reproductive0.69811672
154MP0001853_heart_inflammation0.68402680
155MP0002095_abnormal_skin_pigmentation0.66973476
156MP0004085_abnormal_heartbeat0.66788954
157MP0001986_abnormal_taste_sensitivity0.66788562
158MP0002069_abnormal_eating/drinking_beha0.66617483
159MP0002234_abnormal_pharynx_morphology0.66415046
160MP0005391_vision/eye_phenotype0.66288726
161MP0003950_abnormal_plasma_membrane0.66080986
162MP0001943_abnormal_respiration0.65226572
163MP0000751_myopathy0.65108445
164MP0005075_abnormal_melanosome_morpholog0.64351059
165MP0002295_abnormal_pulmonary_circulatio0.64238722
166MP0002938_white_spotting0.63875316
167MP0001346_abnormal_lacrimal_gland0.62265467
168MP0008874_decreased_physiological_sensi0.60272373
169MP0002090_abnormal_vision0.58555903
170MP0003633_abnormal_nervous_system0.57916211
171MP0000613_abnormal_salivary_gland0.57692284
172MP0004133_heterotaxia0.57205500

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)4.59943000
2Acute necrotizing encephalopathy (HP:0006965)4.56950420
3Neurofibrillary tangles (HP:0002185)4.21339215
4Cerebral inclusion bodies (HP:0100314)4.03764403
5Focal motor seizures (HP:0011153)4.02216021
6Sensory axonal neuropathy (HP:0003390)3.90314264
7Progressive macrocephaly (HP:0004481)3.90198731
8Mitochondrial inheritance (HP:0001427)3.88815488
9Abnormal mitochondria in muscle tissue (HP:0008316)3.78630559
10Myokymia (HP:0002411)3.64063628
11Parakeratosis (HP:0001036)3.52827034
12Acute encephalopathy (HP:0006846)3.49245159
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.32113528
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29587513
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29587513
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.27767518
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.27767518
18Macrocytic anemia (HP:0001972)3.18503568
19Optic disc pallor (HP:0000543)3.15999272
20Atonic seizures (HP:0010819)3.15435671
21Abnormal ciliary motility (HP:0012262)3.14076077
22Lactic acidosis (HP:0003128)3.13614113
23Increased hepatocellular lipid droplets (HP:0006565)3.13524728
24Increased serum lactate (HP:0002151)3.11105206
25Methylmalonic acidemia (HP:0002912)3.08861916
26Abnormality of methionine metabolism (HP:0010901)3.06774624
27Renal Fanconi syndrome (HP:0001994)3.01205757
28Focal seizures (HP:0007359)3.00800892
29Type I transferrin isoform profile (HP:0003642)2.96901068
30Abnormal number of erythroid precursors (HP:0012131)2.95822373
31Abnormality of cells of the erythroid lineage (HP:0012130)2.94256049
32Absent/shortened dynein arms (HP:0200106)2.93870559
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.93870559
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93026754
35Increased CSF lactate (HP:0002490)2.92391505
36Abnormal respiratory motile cilium physiology (HP:0012261)2.85661370
37Methylmalonic aciduria (HP:0012120)2.84003795
38Leukodystrophy (HP:0002415)2.83580786
39Congenital, generalized hypertrichosis (HP:0004540)2.83036160
40Reticulocytopenia (HP:0001896)2.82601611
41Pheochromocytoma (HP:0002666)2.81798663
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.81755538
43Abnormal respiratory motile cilium morphology (HP:0005938)2.77847100
44Abnormal respiratory epithelium morphology (HP:0012253)2.77847100
45Cerebral hemorrhage (HP:0001342)2.77646355
46Hepatocellular necrosis (HP:0001404)2.77634441
47Visual hallucinations (HP:0002367)2.72960983
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70561845
49Peripheral hypomyelination (HP:0007182)2.67156227
50Neuroendocrine neoplasm (HP:0100634)2.65798209
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64138417
52Progressive cerebellar ataxia (HP:0002073)2.62684248
53Lethargy (HP:0001254)2.60439074
54Hyperventilation (HP:0002883)2.57371969
55Broad-based gait (HP:0002136)2.56932791
56Respiratory difficulties (HP:0002880)2.54899720
57Reduced antithrombin III activity (HP:0001976)2.53981653
58Lipid accumulation in hepatocytes (HP:0006561)2.53707744
59Aplastic anemia (HP:0001915)2.52262803
60Abnormality of the corticospinal tract (HP:0002492)2.49569804
61Meckel diverticulum (HP:0002245)2.47839039
62Increased muscle lipid content (HP:0009058)2.47414800
63Oral leukoplakia (HP:0002745)2.46282851
64Hypothermia (HP:0002045)2.45864418
65Dysmetria (HP:0001310)2.41889274
66Abnormality of serum amino acid levels (HP:0003112)2.39579078
67Epileptic encephalopathy (HP:0200134)2.36401647
68Vaginal atresia (HP:0000148)2.35800064
69Abnormal protein glycosylation (HP:0012346)2.35041721
70Abnormal glycosylation (HP:0012345)2.35041721
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35041721
72Abnormal protein N-linked glycosylation (HP:0012347)2.35041721
73Abnormality of the ileum (HP:0001549)2.34107769
74Abnormality of the parathyroid morphology (HP:0011766)2.33729687
75Degeneration of anterior horn cells (HP:0002398)2.32943702
76Abnormality of the anterior horn cell (HP:0006802)2.32943702
77Amblyopia (HP:0000646)2.32704624
78Genital tract atresia (HP:0001827)2.31719346
79Dialeptic seizures (HP:0011146)2.30683016
80Abnormality of the labia minora (HP:0012880)2.29201138
81Megaloblastic anemia (HP:0001889)2.28963257
82Esotropia (HP:0000565)2.28422480
83Supranuclear gaze palsy (HP:0000605)2.27497049
84Abnormal pupillary function (HP:0007686)2.27196988
853-Methylglutaconic aciduria (HP:0003535)2.25042960
86Microvesicular hepatic steatosis (HP:0001414)2.24583195
87Abnormality of the preputium (HP:0100587)2.24356336
88Abnormality of chromosome stability (HP:0003220)2.23772059
89Absence seizures (HP:0002121)2.21910314
90Colon cancer (HP:0003003)2.21445475
91Retinal dysplasia (HP:0007973)2.19804651
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.19064589
93Abnormality of urine glucose concentration (HP:0011016)2.19003687
94Glycosuria (HP:0003076)2.19003687
95Cerebral edema (HP:0002181)2.18279185
96Delusions (HP:0000746)2.16600451
97Abnormality of placental membranes (HP:0011409)2.15591243
98Amniotic constriction ring (HP:0009775)2.15591243
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15467215
100Abnormality of alanine metabolism (HP:0010916)2.15467215
101Hyperalaninemia (HP:0003348)2.15467215
102CNS demyelination (HP:0007305)2.12398034
103Congenital ichthyosiform erythroderma (HP:0007431)2.11084709
104Pancreatic fibrosis (HP:0100732)2.10259069
105Pancreatic cysts (HP:0001737)2.10107517
106Respiratory failure (HP:0002878)2.09440754
107Generalized aminoaciduria (HP:0002909)2.08909419
108Hyperglycinemia (HP:0002154)2.07645642
109Abnormality of the axillary hair (HP:0100134)2.07436814
110Abnormality of secondary sexual hair (HP:0009888)2.07436814
111Pancytopenia (HP:0001876)2.06896224
112Febrile seizures (HP:0002373)2.06706812
113Increased intramyocellular lipid droplets (HP:0012240)2.06411940
114Exercise intolerance (HP:0003546)2.05806882
115Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05263639
116X-linked dominant inheritance (HP:0001423)2.03555866
117Abnormal lung lobation (HP:0002101)2.02230229
118Cupped ear (HP:0000378)2.01712258
119Alacrima (HP:0000522)2.01003788
120Chromsome breakage (HP:0040012)2.00511745
121Anxiety (HP:0000739)2.00499445
122True hermaphroditism (HP:0010459)1.98359582
123Sparse eyelashes (HP:0000653)1.98036628
124Gait imbalance (HP:0002141)1.97972326
125Polyphagia (HP:0002591)1.97304110
126Abnormality of glycolysis (HP:0004366)1.94152578
127Increased serum pyruvate (HP:0003542)1.94152578
128Abnormality of renal resorption (HP:0011038)1.93598586
129Pallor (HP:0000980)1.92805219
130Stenosis of the external auditory canal (HP:0000402)1.91305728
131Hypoglycemic coma (HP:0001325)1.91154175
132Hyperphosphaturia (HP:0003109)1.90666846
133Generalized tonic-clonic seizures (HP:0002069)1.90229599
134Medial flaring of the eyebrow (HP:0010747)1.89639569
135Anomalous pulmonary venous return (HP:0010772)1.87294484
136Rhinitis (HP:0012384)1.87112533
137Testicular atrophy (HP:0000029)1.87023808
138Spastic gait (HP:0002064)1.86684988
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.85790412
140Abnormality of vitamin B metabolism (HP:0004340)1.85531048
141J-shaped sella turcica (HP:0002680)1.83927263
142Birth length less than 3rd percentile (HP:0003561)1.83422962
143Molar tooth sign on MRI (HP:0002419)1.83414790
144Abnormality of midbrain morphology (HP:0002418)1.83414790
145Hyperthyroidism (HP:0000836)1.81400517
146Septo-optic dysplasia (HP:0100842)1.80904421
147Muscle hypertrophy of the lower extremities (HP:0008968)1.80596660
148Hepatic necrosis (HP:0002605)1.79677868
149Akinesia (HP:0002304)1.79582399
150Dicarboxylic aciduria (HP:0003215)1.77308558
151Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77308558
152Congenital primary aphakia (HP:0007707)1.76669168
153Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76606851
154Hypoplastic pelvis (HP:0008839)1.75629213
155Infantile muscular hypotonia (HP:0008947)1.75538570
156Duodenal stenosis (HP:0100867)1.75523308
157Small intestinal stenosis (HP:0012848)1.75523308
158Hemiparesis (HP:0001269)1.75003192
159Atelectasis (HP:0100750)1.74403400
160Progressive external ophthalmoplegia (HP:0000590)1.73126135
161Diminished movement (HP:0002374)1.71838707
162Insidious onset (HP:0003587)1.71833061
163Termporal pattern (HP:0011008)1.71833061
164Abnormality of the pulmonary veins (HP:0011718)1.71253367
165Blindness (HP:0000618)1.70868385
166Progressive inability to walk (HP:0002505)1.68838857
167Thickened helices (HP:0000391)1.68743686
168Sclerocornea (HP:0000647)1.68740324
169Increased circulating renin level (HP:0000848)1.68726778
170Chin dimple (HP:0010751)1.66589179
171Abnormality of sulfur amino acid metabolism (HP:0004339)1.66257927
172Exertional dyspnea (HP:0002875)1.65966171
173Drooling (HP:0002307)1.65917496
174Triphalangeal thumb (HP:0001199)1.64215789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.34413813
2BUB14.14312903
3PNCK4.11257026
4STK393.64791290
5CDK193.08322890
6CASK2.92300026
7EIF2AK12.81315780
8SRPK12.79099980
9CDC72.76154229
10NEK12.72017254
11ZAK2.56290783
12EIF2AK32.51888671
13EPHA42.51386338
14OXSR12.44770304
15TNIK2.39555262
16MAPKAPK52.34456828
17GRK52.27876957
18MAP3K122.14379027
19PLK32.10284707
20TTK2.05034870
21NTRK32.04531575
22FGR2.04364357
23TSSK61.95220095
24NUAK11.89688290
25MARK11.89098995
26CSNK1G31.86131551
27PLK41.85212748
28BRSK21.80171241
29NME11.80072582
30WEE11.79440704
31BCR1.78465420
32TRIM281.77400501
33RIPK41.72995145
34FES1.70476837
35MAP2K71.68783192
36MAP3K41.67405018
37WNK41.66428910
38MKNK11.65697803
39NTRK11.60542883
40MKNK21.57910877
41PKN11.57511182
42PLK21.54445654
43MAPK131.52733792
44MST41.51731940
45TAF11.51675511
46ARAF1.49800739
47GRK71.48169467
48CSNK1G21.44772979
49CAMK2B1.42616901
50PLK11.38728037
51ADRBK21.37397584
52UHMK11.36683933
53CSNK1G11.33637484
54BMPR1B1.31981440
55MAP2K41.31440931
56MAP3K91.28888134
57BCKDK1.26891538
58IRAK21.26729637
59PTK2B1.26111787
60CAMK2D1.25256628
61CAMK2A1.23662995
62PDK21.17745923
63BMPR21.15096661
64BRSK11.11856613
65MAP4K21.09961816
66MINK11.09815029
67ROCK21.09748926
68TLK11.07891937
69AURKB1.07061505
70STK161.04170541
71LIMK10.99777104
72TYRO30.99583231
73PBK0.97295005
74ERBB30.94547093
75CDK50.93741392
76EIF2AK20.93612305
77MAPK150.93353505
78ADRBK10.93076889
79IRAK10.92104348
80GRK60.88661851
81CSNK1A1L0.88369577
82CDK140.88151478
83PAK40.87016826
84MUSK0.86911247
85NTRK20.84649106
86WNK10.80173322
87ATR0.80007451
88CDK11A0.79691824
89DYRK20.79594277
90CCNB10.79138532
91STK38L0.78778469
92INSRR0.77293973
93CHEK20.76876225
94CDK150.75326805
95NEK60.74208984
96CDK180.72961304
97PRKD20.71545090
98PRKCQ0.71380551
99EPHB10.71380412
100CAMK2G0.69389945
101STK40.69216691
102PRKCG0.68918580
103CSNK2A20.68720911
104PRKCE0.67094312
105CSNK2A10.65993117
106CDK80.65845656
107PHKG20.65227172
108PHKG10.65227172
109AURKA0.64899781
110DYRK30.64807773
111ACVR1B0.64510316
112DYRK1A0.63240173
113MYLK0.60944516
114NEK20.60497529
115SCYL20.59805963
116NME20.56795758
117ABL20.55901935
118PRKACA0.53288497
119DAPK10.51854051
120MST1R0.51825864
121ERBB40.50721857
122ATM0.50278996
123TESK10.49748759
124PASK0.49003312
125FGFR20.46729458
126PAK60.46541290
127MET0.46406111
128RPS6KA50.46170892
129CHEK10.46161051
130FYN0.45937420
131CDK70.45415090
132VRK10.44958319
133STK30.44118594
134PAK30.43640658
135MAP3K20.43530206
136KSR20.42723189
137PIM20.42211578
138CSNK1E0.41461554
139ILK0.41062840
140MAP3K130.40328432
141RPS6KA40.40140954
142CDK30.39131866
143MOS0.38889360
144FGFR10.38639186
145BRAF0.36714165
146CAMK1G0.36314388
147CSNK1A10.33081627
148WNK30.32408997
149PRKG10.31934765
150PRKCI0.30756362
151FRK0.30425226
152STK110.29653981
153PRKCZ0.29509020
154GRK10.29285922
155DAPK30.28734224
156SIK20.28006304
157RET0.27902278
158EPHB20.27471829
159KDR0.26828999
160OBSCN0.26710323
161ALK0.26271539
162CDK10.26233819
163TGFBR10.25572228

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.90271499
2Parkinsons disease_Homo sapiens_hsa050124.00330598
3Alzheimers disease_Homo sapiens_hsa050103.36736183
4Mismatch repair_Homo sapiens_hsa034303.10334337
5Nicotine addiction_Homo sapiens_hsa050333.07175304
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95385522
7DNA replication_Homo sapiens_hsa030302.92163160
8Huntingtons disease_Homo sapiens_hsa050162.68383952
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59429707
10Homologous recombination_Homo sapiens_hsa034402.57315939
11Collecting duct acid secretion_Homo sapiens_hsa049662.52621932
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27481444
13Cardiac muscle contraction_Homo sapiens_hsa042602.21017771
14Serotonergic synapse_Homo sapiens_hsa047262.20197591
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19746762
16Fatty acid elongation_Homo sapiens_hsa000622.04773265
17Spliceosome_Homo sapiens_hsa030402.01568775
18Glutamatergic synapse_Homo sapiens_hsa047242.01413688
19Nucleotide excision repair_Homo sapiens_hsa034202.01407731
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98889889
21Synaptic vesicle cycle_Homo sapiens_hsa047211.92985988
22GABAergic synapse_Homo sapiens_hsa047271.89808080
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87259235
24Amphetamine addiction_Homo sapiens_hsa050311.85488640
25Steroid biosynthesis_Homo sapiens_hsa001001.81800833
26Base excision repair_Homo sapiens_hsa034101.75584188
27Taste transduction_Homo sapiens_hsa047421.71742807
28One carbon pool by folate_Homo sapiens_hsa006701.69196617
29Non-homologous end-joining_Homo sapiens_hsa034501.68935568
30Long-term depression_Homo sapiens_hsa047301.68273703
31RNA transport_Homo sapiens_hsa030131.68088613
32Pyrimidine metabolism_Homo sapiens_hsa002401.66147187
33Cocaine addiction_Homo sapiens_hsa050301.65464147
34Fanconi anemia pathway_Homo sapiens_hsa034601.64971707
35Morphine addiction_Homo sapiens_hsa050321.64413157
36* Ribosome_Homo sapiens_hsa030101.63924502
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61995274
38Dopaminergic synapse_Homo sapiens_hsa047281.59252068
39RNA degradation_Homo sapiens_hsa030181.57031867
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56593139
41Ether lipid metabolism_Homo sapiens_hsa005651.55853625
42Propanoate metabolism_Homo sapiens_hsa006401.55533580
43Basal transcription factors_Homo sapiens_hsa030221.52904631
44Vibrio cholerae infection_Homo sapiens_hsa051101.50844484
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49364536
46Long-term potentiation_Homo sapiens_hsa047201.48900744
47Phototransduction_Homo sapiens_hsa047441.47688716
48Protein export_Homo sapiens_hsa030601.47479288
49Circadian entrainment_Homo sapiens_hsa047131.46330983
50Axon guidance_Homo sapiens_hsa043601.39489922
51Folate biosynthesis_Homo sapiens_hsa007901.35153503
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34609740
53Salivary secretion_Homo sapiens_hsa049701.32280430
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32210909
55Pyruvate metabolism_Homo sapiens_hsa006201.31068669
56Renin secretion_Homo sapiens_hsa049241.25295837
57Cholinergic synapse_Homo sapiens_hsa047251.19970564
58Purine metabolism_Homo sapiens_hsa002301.19407490
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.19220615
60Cell cycle_Homo sapiens_hsa041101.18378994
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15274569
62Glutathione metabolism_Homo sapiens_hsa004801.14853716
63Rheumatoid arthritis_Homo sapiens_hsa053231.07118513
64Gastric acid secretion_Homo sapiens_hsa049711.05978828
65Calcium signaling pathway_Homo sapiens_hsa040201.05372332
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05328868
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05322145
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03376579
69Olfactory transduction_Homo sapiens_hsa047400.95267173
70African trypanosomiasis_Homo sapiens_hsa051430.94277944
71Gap junction_Homo sapiens_hsa045400.93760079
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90858257
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88430275
74Oxytocin signaling pathway_Homo sapiens_hsa049210.87702351
75GnRH signaling pathway_Homo sapiens_hsa049120.86699878
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84646468
77Tyrosine metabolism_Homo sapiens_hsa003500.83902570
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79362284
79Carbon metabolism_Homo sapiens_hsa012000.77903424
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77696423
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77492388
82Vitamin B6 metabolism_Homo sapiens_hsa007500.76536887
83Peroxisome_Homo sapiens_hsa041460.76283553
84Linoleic acid metabolism_Homo sapiens_hsa005910.75672251
85Insulin secretion_Homo sapiens_hsa049110.74236410
86Alcoholism_Homo sapiens_hsa050340.73875017
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.73805045
88Sphingolipid metabolism_Homo sapiens_hsa006000.73387031
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73023832
90Selenocompound metabolism_Homo sapiens_hsa004500.72134695
91Sulfur metabolism_Homo sapiens_hsa009200.70661145
92Melanogenesis_Homo sapiens_hsa049160.68550765
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67646584
94Proteasome_Homo sapiens_hsa030500.67386437
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66414345
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65920718
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63603844
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.62698358
99Butanoate metabolism_Homo sapiens_hsa006500.61942028
100Caffeine metabolism_Homo sapiens_hsa002320.60830053
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60092259
102Biosynthesis of amino acids_Homo sapiens_hsa012300.59096581
103Chemical carcinogenesis_Homo sapiens_hsa052040.58459293
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58066993
105mRNA surveillance pathway_Homo sapiens_hsa030150.57752339
106Sulfur relay system_Homo sapiens_hsa041220.56742423
107Pancreatic secretion_Homo sapiens_hsa049720.56660395
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56101305
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.55126762
110Tryptophan metabolism_Homo sapiens_hsa003800.55051374
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53408157
112Vitamin digestion and absorption_Homo sapiens_hsa049770.52596012
113p53 signaling pathway_Homo sapiens_hsa041150.50759012
114Fatty acid degradation_Homo sapiens_hsa000710.50736496
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50620330
116Phenylalanine metabolism_Homo sapiens_hsa003600.49385808
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.48696277
118N-Glycan biosynthesis_Homo sapiens_hsa005100.48272202
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47839250
120Ovarian steroidogenesis_Homo sapiens_hsa049130.47126331
121Phagosome_Homo sapiens_hsa041450.46703165
122Retinol metabolism_Homo sapiens_hsa008300.46650641
123Histidine metabolism_Homo sapiens_hsa003400.45690370
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45571344
125cAMP signaling pathway_Homo sapiens_hsa040240.43597113
126Ras signaling pathway_Homo sapiens_hsa040140.42483256
127RNA polymerase_Homo sapiens_hsa030200.41806714
128Choline metabolism in cancer_Homo sapiens_hsa052310.41352379
129Mineral absorption_Homo sapiens_hsa049780.40938963
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.40608803
131Hedgehog signaling pathway_Homo sapiens_hsa043400.39819683
132Fatty acid metabolism_Homo sapiens_hsa012120.39325250
133Nitrogen metabolism_Homo sapiens_hsa009100.39203466
134Metabolic pathways_Homo sapiens_hsa011000.38768683
135Estrogen signaling pathway_Homo sapiens_hsa049150.38742811
136beta-Alanine metabolism_Homo sapiens_hsa004100.37823109
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36257862
138Systemic lupus erythematosus_Homo sapiens_hsa053220.36112192
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.35829282
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35553176
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35010121
142Arachidonic acid metabolism_Homo sapiens_hsa005900.34656934
143Dorso-ventral axis formation_Homo sapiens_hsa043200.34211855
144Prion diseases_Homo sapiens_hsa050200.34084750
145Renal cell carcinoma_Homo sapiens_hsa052110.34061621
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.30847654
147Epstein-Barr virus infection_Homo sapiens_hsa051690.29118334
148Autoimmune thyroid disease_Homo sapiens_hsa053200.28829789
149Thyroid hormone synthesis_Homo sapiens_hsa049180.28096562
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26713089
151Regulation of autophagy_Homo sapiens_hsa041400.26599041
152Arginine and proline metabolism_Homo sapiens_hsa003300.25744027
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25452294
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24509561
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24494359
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24127244
157MAPK signaling pathway_Homo sapiens_hsa040100.23760885
158Wnt signaling pathway_Homo sapiens_hsa043100.22848268
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.21551642
160ErbB signaling pathway_Homo sapiens_hsa040120.19900033
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18538221
162Oocyte meiosis_Homo sapiens_hsa041140.18263408
163Dilated cardiomyopathy_Homo sapiens_hsa054140.16778345
164Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16331413
165Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16101301
166Fat digestion and absorption_Homo sapiens_hsa049750.13540575
167Pentose phosphate pathway_Homo sapiens_hsa000300.10830600
168TGF-beta signaling pathway_Homo sapiens_hsa043500.10089454
169Starch and sucrose metabolism_Homo sapiens_hsa005000.06972192

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