MRGPRX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.60151719
2melanin biosynthetic process (GO:0042438)8.46997230
3melanin metabolic process (GO:0006582)7.52728834
4acrosome reaction (GO:0007340)6.83584067
5secondary metabolite biosynthetic process (GO:0044550)6.68868642
6plasma membrane fusion (GO:0045026)6.29832748
7tyrosine metabolic process (GO:0006570)6.26236765
8sperm motility (GO:0030317)5.90839641
9keratinocyte proliferation (GO:0043616)5.52332754
10enteric nervous system development (GO:0048484)5.24200726
11keratinocyte development (GO:0003334)5.21754945
12negative regulation of chemokine production (GO:0032682)4.75007910
13negative regulation of stress fiber assembly (GO:0051497)4.70213494
14negative regulation of macroautophagy (GO:0016242)4.58008865
15pigment cell differentiation (GO:0050931)4.48739038
16desmosome organization (GO:0002934)4.47068315
17peptidyl-proline hydroxylation (GO:0019511)4.42253438
18regulation of cytokine production involved in inflammatory response (GO:1900015)4.35656697
19purine ribonucleotide transport (GO:0015868)4.35300462
20negative regulation of focal adhesion assembly (GO:0051895)4.30885174
21negative regulation of cell junction assembly (GO:1901889)4.30885174
22negative regulation of adherens junction organization (GO:1903392)4.30885174
23melanocyte differentiation (GO:0030318)4.27376617
24response to methylmercury (GO:0051597)4.25984377
25multicellular organism reproduction (GO:0032504)4.01093890
26purine nucleotide transport (GO:0015865)3.99070407
27rRNA methylation (GO:0031167)3.98559577
28spermatid development (GO:0007286)3.97200428
29negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.91276401
30rRNA modification (GO:0000154)3.80743370
31cell-substrate junction assembly (GO:0007044)3.69784384
32sperm-egg recognition (GO:0035036)3.69699140
33negative regulation of actin filament bundle assembly (GO:0032232)3.59729553
34sperm capacitation (GO:0048240)3.59575664
35protein localization to endosome (GO:0036010)3.58109600
36reproduction (GO:0000003)3.54712895
37chromosome condensation (GO:0030261)3.46021444
38binding of sperm to zona pellucida (GO:0007339)3.40915507
39DNA packaging (GO:0006323)3.40113494
40peptidyl-arginine omega-N-methylation (GO:0035247)3.38825008
41developmental pigmentation (GO:0048066)3.36345863
42peripheral nervous system development (GO:0007422)3.34846383
43adhesion of symbiont to host (GO:0044406)3.33593486
44basement membrane organization (GO:0071711)3.31636280
45regulation of integrin-mediated signaling pathway (GO:2001044)3.25805313
46hyaluronan catabolic process (GO:0030214)3.24089120
47spermatid nucleus differentiation (GO:0007289)3.21818194
48virion attachment to host cell (GO:0019062)3.21210995
49adhesion of symbiont to host cell (GO:0044650)3.21210995
50phenol-containing compound biosynthetic process (GO:0046189)3.21003043
51axon regeneration (GO:0031103)3.20949183
52calcium ion-dependent exocytosis (GO:0017156)3.20197893
53response to pheromone (GO:0019236)3.19380220
54neuron remodeling (GO:0016322)3.15735619
55sialylation (GO:0097503)3.14486814
56regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.14485109
57negative regulation of skeletal muscle tissue development (GO:0048642)3.13165769
58protein hydroxylation (GO:0018126)3.06839670
59cornea development in camera-type eye (GO:0061303)3.05002869
60spermatogenesis (GO:0007283)3.02441724
61regulation of hair follicle development (GO:0051797)3.00544756
62male gamete generation (GO:0048232)3.00487762
63negative regulation of glycoprotein biosynthetic process (GO:0010561)2.99619060
64single strand break repair (GO:0000012)2.96519065
65neural crest cell migration (GO:0001755)2.92207877
66protein polyglutamylation (GO:0018095)2.90453740
67regulation of keratinocyte proliferation (GO:0010837)2.90448605
68glomerular basement membrane development (GO:0032836)2.89653348
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89483710
70regulation of lipoprotein metabolic process (GO:0050746)2.86315192
714-hydroxyproline metabolic process (GO:0019471)2.82240301
72single fertilization (GO:0007338)2.80882183
73gamete generation (GO:0007276)2.79582844
74negative regulation of Rho protein signal transduction (GO:0035024)2.77910158
75positive regulation of hair follicle development (GO:0051798)2.77776781
76positive regulation of hair cycle (GO:0042635)2.77776781
77sexual reproduction (GO:0019953)2.76898595
78nucleoside transmembrane transport (GO:1901642)2.76753227
79endosome to melanosome transport (GO:0035646)2.75955872
80endosome to pigment granule transport (GO:0043485)2.75955872
81motile cilium assembly (GO:0044458)2.75854447
82cellular zinc ion homeostasis (GO:0006882)2.75224025
83cell-cell recognition (GO:0009988)2.74990330
84peptidyl-arginine methylation (GO:0018216)2.74164676
85peptidyl-arginine N-methylation (GO:0035246)2.74164676
86antigen processing and presentation via MHC class Ib (GO:0002475)2.74111772
87positive regulation of Rab GTPase activity (GO:0032851)2.72759482
88regulation of Rab GTPase activity (GO:0032313)2.72759482
89bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71697341
90phosphatidylethanolamine biosynthetic process (GO:0006646)2.70784865
91glomerular visceral epithelial cell development (GO:0072015)2.69549811
92seminiferous tubule development (GO:0072520)2.68392109
93regulation of skeletal muscle cell differentiation (GO:2001014)2.68025586
94glucose 6-phosphate metabolic process (GO:0051156)2.66821933
95microtubule depolymerization (GO:0007019)2.65933420
96membrane tubulation (GO:0097320)2.65636258
97histone arginine methylation (GO:0034969)2.65013929
98nucleotide transmembrane transport (GO:1901679)2.65003278
99adenine nucleotide transport (GO:0051503)2.64867328
100hemidesmosome assembly (GO:0031581)11.5339967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.48101963
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65845500
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.61355675
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48776926
5TP63_22573176_ChIP-Seq_HFKS_Human2.40093346
6LXR_22292898_ChIP-Seq_THP-1_Human2.29264381
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26221457
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14035579
9YY1_22570637_ChIP-Seq_MALME-3M_Human2.06874787
10TP63_17297297_ChIP-ChIP_HaCaT_Human10.3763292
11BCOR_27268052_Chip-Seq_Bcells_Human1.96135674
12P68_20966046_ChIP-Seq_HELA_Human1.88161615
13PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.85312111
14CTCF_20526341_ChIP-Seq_ESCs_Human1.74708484
15MITF_21258399_ChIP-Seq_MELANOMA_Human1.68446957
16SMC4_20622854_ChIP-Seq_HELA_Human1.62554489
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.58075849
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57109420
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55232018
20E2F1_20622854_ChIP-Seq_HELA_Human1.55181700
21JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54739836
22SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53084654
23BCL6_27268052_Chip-Seq_Bcells_Human1.53055534
24UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52509430
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50318051
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48031054
27PHF8_20622854_ChIP-Seq_HELA_Human1.44310369
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41456169
29CTCF_27219007_Chip-Seq_Bcells_Human1.38034896
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.36902249
31TET1_21490601_ChIP-Seq_MESCs_Mouse1.36149326
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.35965547
33* RAC3_21632823_ChIP-Seq_H3396_Human1.35857314
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33299578
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31780232
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31159550
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31068866
38GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.29849865
39CSB_26484114_Chip-Seq_FIBROBLAST_Human1.27153275
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25069328
41EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.24661825
42P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24512499
43KLF5_25053715_ChIP-Seq_YYC3_Human1.24102590
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21453071
45MYC_19829295_ChIP-Seq_ESCs_Human1.20763641
46TP53_22127205_ChIP-Seq_IMR90_Human1.19880338
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19274891
48P300_27268052_Chip-Seq_Bcells_Human1.19018179
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18417118
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18173056
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.17964049
52ETS1_21867929_ChIP-Seq_TH2_Mouse1.17725018
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17015293
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15975269
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15322124
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15107565
57TP63_23658742_ChIP-Seq_EP156T_Human1.13384018
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12532339
59RARA_24833708_ChIP-Seq_LIVER_Mouse1.11341153
60ERA_21632823_ChIP-Seq_H3396_Human1.10300946
61SCL_19346495_ChIP-Seq_HPC-7_Human1.08776952
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07417762
63CTCF_21964334_Chip-Seq_Bcells_Human1.06804166
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06335704
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03789048
66VDR_21846776_ChIP-Seq_THP-1_Human1.03045195
67RACK7_27058665_Chip-Seq_MCF-7_Human1.02747487
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.02530006
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.01263696
70CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99776957
71OCT4_19829295_ChIP-Seq_ESCs_Human0.99563554
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98883424
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98883424
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98877347
75ATF3_27146783_Chip-Seq_COLON_Human0.98480237
76RARB_24833708_ChIP-Seq_LIVER_Mouse0.98329607
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97799133
78P53_21459846_ChIP-Seq_SAOS-2_Human0.97291532
79SA1_27219007_Chip-Seq_Bcells_Human0.97034166
80YY1_21170310_ChIP-Seq_MESCs_Mouse0.94896386
81WDR5_24793694_ChIP-Seq_LNCAP_Human0.94236190
82ZNF263_19887448_ChIP-Seq_K562_Human0.92697746
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91476313
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91425291
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91372877
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90973239
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90278674
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89913116
89KLF4_19829295_ChIP-Seq_ESCs_Human0.89857223
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89077194
91NANOG_20526341_ChIP-Seq_ESCs_Human0.88917511
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.88502611
93STAT1_17558387_ChIP-Seq_HELA_Human0.87782194
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87753327
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.87083234
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86622631
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.86549195
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86435360
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85258398
100MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84878541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.82106013
2MP0000569_abnormal_digit_pigmentation5.89570377
3MP0000015_abnormal_ear_pigmentation5.05489503
4MP0005257_abnormal_intraocular_pressure4.97993442
5MP0005408_hypopigmentation4.90741054
6MP0003136_yellow_coat_color4.31549676
7MP0005075_abnormal_melanosome_morpholog4.29954046
8MP0004381_abnormal_hair_follicle4.29716435
9MP0000579_abnormal_nail_morphology3.84735218
10MP0005174_abnormal_tail_pigmentation3.63238384
11MP0002095_abnormal_skin_pigmentation3.49831400
12MP0005410_abnormal_fertilization2.85449529
13MP0008260_abnormal_autophagy2.80459327
14MP0000372_irregular_coat_pigmentation2.63835682
15MP0005058_abnormal_lysosome_morphology2.18914346
16MP0000371_diluted_coat_color2.09540644
17MP0009840_abnormal_foam_cell1.86590115
18MP0005377_hearing/vestibular/ear_phenot1.78273922
19MP0003878_abnormal_ear_physiology1.78273922
20MP0002075_abnormal_coat/hair_pigmentati1.76388136
21MP0002098_abnormal_vibrissa_morphology1.64904140
22MP0001324_abnormal_eye_pigmentation1.61363216
23MP0000467_abnormal_esophagus_morphology1.58664538
24MP0001186_pigmentation_phenotype1.58243423
25MP0002060_abnormal_skin_morphology1.57441500
26MP0003329_amyloid_beta_deposits1.52037973
27MP0003191_abnormal_cellular_cholesterol1.47875866
28MP0001849_ear_inflammation1.46977576
29MP0008438_abnormal_cutaneous_collagen1.34286219
30MP0003172_abnormal_lysosome_physiology1.33682177
31MP0002653_abnormal_ependyma_morphology1.30439382
32MP0002877_abnormal_melanocyte_morpholog1.19893734
33MP0004272_abnormal_basement_membrane1.11658922
34MP0001216_abnormal_epidermal_layer1.11183666
35MP0001348_abnormal_lacrimal_gland1.09347300
36MP0002796_impaired_skin_barrier1.09053521
37MP0005670_abnormal_white_adipose1.05695411
38MP0003453_abnormal_keratinocyte_physiol1.02565331
39MP0000762_abnormal_tongue_morphology1.01545940
40MP0000678_abnormal_parathyroid_gland1.00586993
41MP0010234_abnormal_vibrissa_follicle0.95988766
42MP0005275_abnormal_skin_tensile0.94161788
43MP0005197_abnormal_uvea_morphology0.92943904
44MP0003705_abnormal_hypodermis_morpholog0.89225369
45MP0000377_abnormal_hair_follicle0.87916484
46MP0005409_darkened_coat_color0.87822429
47MP0000367_abnormal_coat/_hair0.84210851
48MP0002090_abnormal_vision0.82961679
49MP0002938_white_spotting0.79964525
50MP0010771_integument_phenotype0.78893011
51MP0003698_abnormal_male_reproductive0.78436991
52MP0000604_amyloidosis0.73333791
53MP0005248_abnormal_Harderian_gland0.72986732
54MP0001929_abnormal_gametogenesis0.64695914
55MP0002909_abnormal_adrenal_gland0.64493349
56MP0006054_spinal_hemorrhage0.63483496
57MP0008004_abnormal_stomach_pH0.62916766
58MP0000427_abnormal_hair_cycle0.60736772
59MP0010678_abnormal_skin_adnexa0.60434250
60MP0009053_abnormal_anal_canal0.57983380
61MP0002177_abnormal_outer_ear0.55969376
62MP0000383_abnormal_hair_follicle0.54875533
63MP0005501_abnormal_skin_physiology0.54838522
64MP0003566_abnormal_cell_adhesion0.52766960
65MP0008932_abnormal_embryonic_tissue0.51997173
66MP0009278_abnormal_bone_marrow0.51167632
67MP0000647_abnormal_sebaceous_gland0.50586223
68MP0004742_abnormal_vestibular_system0.48422938
69MP0003634_abnormal_glial_cell0.48240831
70MP0000920_abnormal_myelination0.47512278
71MP0002161_abnormal_fertility/fecundity0.46239070
72MP0000627_abnormal_mammary_gland0.45334702
73MP0002234_abnormal_pharynx_morphology0.44941385
74MP0004147_increased_porphyrin_level0.44578931
75MP0003632_abnormal_nervous_system0.44513020
76MP0000749_muscle_degeneration0.43893788
77MP0005023_abnormal_wound_healing0.43209692
78MP0005451_abnormal_body_composition0.42807926
79MP0008770_decreased_survivor_rate0.42721545
80MP0000566_synostosis0.38967722
81MP0005379_endocrine/exocrine_gland_phen0.38450883
82MP0004885_abnormal_endolymph0.34635771
83MP0001756_abnormal_urination0.34506428
84MP0005193_abnormal_anterior_eye0.32139334
85MP0005464_abnormal_platelet_physiology0.31053322
86MP0002229_neurodegeneration0.30774741
87MP0000639_abnormal_adrenal_gland0.28837792
88MP0003091_abnormal_cell_migration0.28654498
89MP0009643_abnormal_urine_homeostasis0.28582224
90MP0001243_abnormal_dermal_layer0.28351992
91MP0003303_peritoneal_inflammation0.27899180
92MP0002751_abnormal_autonomic_nervous0.27589999
93MP0000733_abnormal_muscle_development0.27231363
94MP0003448_altered_tumor_morphology0.25801143
95MP0002998_abnormal_bone_remodeling0.25709068
96MP0004782_abnormal_surfactant_physiolog0.25141363
97MP0003718_maternal_effect0.24974180
98MP0002132_abnormal_respiratory_system0.24234186
99MP0000470_abnormal_stomach_morphology0.24225372
100MP0000003_abnormal_adipose_tissue0.24039197

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)8.00867895
2Patchy hypopigmentation of hair (HP:0011365)7.23422096
3Fragile nails (HP:0001808)6.81101689
4Milia (HP:0001056)6.52426071
5Atrophic scars (HP:0001075)5.57602434
6Onycholysis (HP:0001806)5.43219624
7Albinism (HP:0001022)5.39010702
8Plantar hyperkeratosis (HP:0007556)4.96579019
9Generalized hypopigmentation (HP:0007513)4.83590013
10Ocular albinism (HP:0001107)4.78398117
11Blue irides (HP:0000635)4.55557465
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.25147288
13Hypoplasia of the fovea (HP:0007750)4.25147288
14Iris hypopigmentation (HP:0007730)4.13126862
15Heterochromia iridis (HP:0001100)4.05776360
16Abnormality of nail color (HP:0100643)4.01528226
17Aplasia/Hypoplasia of the macula (HP:0008059)3.90873772
18Premature graying of hair (HP:0002216)3.89900073
19Pili torti (HP:0003777)3.89784087
20Spastic paraparesis (HP:0002313)3.72407733
21Amelogenesis imperfecta (HP:0000705)3.66383263
22Aplasia/Hypoplasia affecting the retina (HP:0008061)3.63077712
23Aplasia cutis congenita (HP:0001057)3.49254646
24Abnormal auditory evoked potentials (HP:0006958)3.33574097
25Hypopigmentation of the fundus (HP:0007894)3.31762931
26Peripheral hypomyelination (HP:0007182)3.28002366
27Nail dystrophy (HP:0008404)3.18839412
28Abnormality of the fovea (HP:0000493)3.13342375
29Thick nail (HP:0001805)3.12651456
30Alopecia of scalp (HP:0002293)3.08532993
31Nasolacrimal duct obstruction (HP:0000579)3.06141001
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.95565569
33Paraparesis (HP:0002385)2.95242169
34Palmoplantar hyperkeratosis (HP:0000972)2.92194243
35Abnormal hair laboratory examination (HP:0003328)2.90755851
36Diaphragmatic weakness (HP:0009113)2.78664109
37Ridged nail (HP:0001807)2.78571016
38Palmar hyperkeratosis (HP:0010765)2.70318185
39Neurofibrillary tangles (HP:0002185)2.69259278
40Abnormal blistering of the skin (HP:0008066)2.69059415
41Hypoplasia of the iris (HP:0007676)2.64797691
42Severe visual impairment (HP:0001141)2.57567173
43Lip pit (HP:0100267)2.56938808
44Cerebellar dysplasia (HP:0007033)2.49858984
45Cerebral inclusion bodies (HP:0100314)2.48529470
46Cerebral hypomyelination (HP:0006808)2.40168698
47Hypoplasia of dental enamel (HP:0006297)2.37141711
48Abnormality of the salivary glands (HP:0010286)2.35519084
49Asymmetric septal hypertrophy (HP:0001670)2.34779625
50Pterygium (HP:0001059)2.33517522
51Large for gestational age (HP:0001520)2.28569902
52Abnormality of the neuromuscular junction (HP:0003398)2.24033518
53Fatigable weakness (HP:0003473)2.24033518
54Selective tooth agenesis (HP:0001592)2.23891218
55Alacrima (HP:0000522)2.20596541
56Protrusio acetabuli (HP:0003179)2.18299646
57Upper limb muscle weakness (HP:0003484)2.14606813
58Natal tooth (HP:0000695)2.13045713
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11814915
60Absent epiphyses (HP:0010577)2.11814915
61Abnormality of the lacrimal duct (HP:0011481)2.11010511
62Generalized hypopigmentation of hair (HP:0011358)2.08048083
63Sparse eyelashes (HP:0000653)2.02849834
64Bilateral sensorineural hearing impairment (HP:0008619)2.01734978
65Achilles tendon contracture (HP:0001771)2.00097884
66Hypodontia (HP:0000668)1.99155364
67Spinal muscular atrophy (HP:0007269)1.98151208
68Type II lissencephaly (HP:0007260)1.95744683
69Abnormality of glycolipid metabolism (HP:0010969)1.95549333
70Abnormality of liposaccharide metabolism (HP:0010968)1.95549333
71Abnormality of glycosphingolipid metabolism (HP:0004343)1.95549333
72Carious teeth (HP:0000670)1.90881518
73Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88097619
74J-shaped sella turcica (HP:0002680)1.86391059
75Male infertility (HP:0003251)1.85412375
76Death in infancy (HP:0001522)1.84282049
77Recurrent corneal erosions (HP:0000495)1.83662144
78Increased neuronal autofluorescent lipopigment (HP:0002074)1.83636684
79Right ventricular cardiomyopathy (HP:0011663)1.83118586
80Hypotrichosis (HP:0001006)1.81573657
81Vacuolated lymphocytes (HP:0001922)1.76846550
82Morphological abnormality of the inner ear (HP:0011390)1.76366755
83Congenital sensorineural hearing impairment (HP:0008527)1.76071676
84Fragile skin (HP:0001030)1.74033480
85Increased cerebral lipofuscin (HP:0011813)1.74015197
86Lower limb hyperreflexia (HP:0002395)1.72170443
87Underdeveloped nasal alae (HP:0000430)1.71088283
88Weak cry (HP:0001612)1.70541676
89Stridor (HP:0010307)1.68618899
90Occipital encephalocele (HP:0002085)1.68406080
91Abnormality of the Achilles tendon (HP:0005109)1.67868412
92Conical tooth (HP:0000698)1.67842850
93Generalized aminoaciduria (HP:0002909)1.67132780
94Sparse scalp hair (HP:0002209)1.66663877
95Anterior segment dysgenesis (HP:0007700)1.66452002
96Insidious onset (HP:0003587)1.63709325
97Termporal pattern (HP:0011008)1.63709325
98Corneal erosion (HP:0200020)1.63017056
99Abnormality of the nasal septum (HP:0000419)1.61768186
100Abnormality of the nasolacrimal system (HP:0000614)1.60824538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF3.90587602
2MUSK3.71861265
3TESK13.48539710
4LMTK23.33726172
5PLK43.29275194
6PIM23.15672070
7DDR22.97216388
8TESK22.97059845
9KSR22.42326499
10MAP3K22.23138079
11NME22.10435058
12MAP4K22.08352044
13KDR2.06246003
14RIPK12.04922137
15PDK21.99774533
16TGFBR21.78693740
17ICK1.67200074
18PAK41.66582152
19MAPKAPK31.62992138
20LATS21.61829892
21MAP3K31.57265741
22TYRO31.53941594
23MST1R1.47119374
24WNK41.41536469
25INSRR1.36782166
26TRIB31.34635409
27RAF11.34614150
28SIK11.29366798
29RPS6KA21.28458484
30NTRK11.23721338
31PDPK11.18857251
32CDK121.17638938
33MET1.17356715
34MOS1.16138455
35MARK31.12476450
36PDK11.06554776
37STK38L1.06163868
38LATS11.04965745
39BRAF1.03396086
40ADRBK21.00958250
41EPHA20.97759376
42STK380.93948518
43PRKD30.91441151
44PLK20.90074477
45GRK70.87535081
46BMX0.85980187
47PBK0.83508928
48ERBB20.83070937
49MATK0.82019203
50VRK20.81244795
51PHKG20.79611333
52PHKG10.79611333
53PRKD10.78738784
54RPS6KA10.72514396
55TAOK30.71047364
56CDK30.69841614
57MAP3K80.68172601
58BTK0.66924043
59PDGFRA0.57092812
60PTK20.55904287
61FER0.55451942
62CSF1R0.55428086
63NEK60.54744882
64AKT20.53375659
65MAP3K60.52557169
66TGFBR10.52504358
67JAK30.52311581
68ERN10.51636064
69NEK20.50810472
70RPS6KA60.49639199
71IRAK30.49075859
72ZAK0.48563337
73PKN20.47850202
74MAP3K90.47823114
75GSK3A0.47291423
76MAP3K10.46657547
77MAP2K10.45677639
78CHUK0.45168485
79PTK2B0.44190373
80ABL20.44096200
81RPS6KL10.43885514
82RPS6KC10.43885514
83MAPK110.42399719
84ZAP700.41955842
85TRPM70.41755379
86CDK70.41653237
87MAPKAPK20.40548339
88MAP2K20.38183748
89TXK0.34622039
90AURKA0.33569554
91MAPKAPK50.30857983
92MAP2K60.30117947
93BCKDK0.29782976
94PIM10.28433936
95MTOR0.28177467
96PRKAA20.27515072
97PRKG20.27101473
98SRC0.25992520
99EPHB20.25382014
100RET0.23564585

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.56938638
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.05398328
3ECM-receptor interaction_Homo sapiens_hsa045123.12829865
4Lysosome_Homo sapiens_hsa041422.75060876
5Other glycan degradation_Homo sapiens_hsa005112.50778673
6Tyrosine metabolism_Homo sapiens_hsa003502.44099099
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.43508510
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39852081
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16761669
10Small cell lung cancer_Homo sapiens_hsa052222.14827460
11Fatty acid biosynthesis_Homo sapiens_hsa000611.87979903
12Nitrogen metabolism_Homo sapiens_hsa009101.73855577
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67558800
14ABC transporters_Homo sapiens_hsa020101.55419184
15Sulfur relay system_Homo sapiens_hsa041221.45714022
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40425511
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37910120
18Amoebiasis_Homo sapiens_hsa051461.37583318
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36939297
20Fructose and mannose metabolism_Homo sapiens_hsa000511.34399728
21Basal transcription factors_Homo sapiens_hsa030221.29528235
22Antigen processing and presentation_Homo sapiens_hsa046121.28477534
23Focal adhesion_Homo sapiens_hsa045101.24062628
24Toxoplasmosis_Homo sapiens_hsa051451.23886344
25Sulfur metabolism_Homo sapiens_hsa009201.22422354
26Fatty acid elongation_Homo sapiens_hsa000621.19408537
27Protein digestion and absorption_Homo sapiens_hsa049741.18199340
28Phagosome_Homo sapiens_hsa041451.18068711
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15169517
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13488267
31Galactose metabolism_Homo sapiens_hsa000521.12714403
32N-Glycan biosynthesis_Homo sapiens_hsa005101.11143548
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08294626
34Olfactory transduction_Homo sapiens_hsa047401.06870833
35Vitamin digestion and absorption_Homo sapiens_hsa049771.05878438
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03814128
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03767555
38Collecting duct acid secretion_Homo sapiens_hsa049661.02236907
39Melanogenesis_Homo sapiens_hsa049161.01197988
40Allograft rejection_Homo sapiens_hsa053300.99771164
41Graft-versus-host disease_Homo sapiens_hsa053320.98673667
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.98500238
43Autoimmune thyroid disease_Homo sapiens_hsa053200.95873808
44Synaptic vesicle cycle_Homo sapiens_hsa047210.95301556
45Dorso-ventral axis formation_Homo sapiens_hsa043200.92622393
46Hematopoietic cell lineage_Homo sapiens_hsa046400.91624939
47Sphingolipid metabolism_Homo sapiens_hsa006000.91410165
48Endocytosis_Homo sapiens_hsa041440.90723315
49Viral myocarditis_Homo sapiens_hsa054160.89879378
50Bladder cancer_Homo sapiens_hsa052190.88928624
51Malaria_Homo sapiens_hsa051440.88459578
52Prion diseases_Homo sapiens_hsa050200.85983373
53Vibrio cholerae infection_Homo sapiens_hsa051100.85717828
54Ribosome_Homo sapiens_hsa030100.84444694
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83306049
56Regulation of autophagy_Homo sapiens_hsa041400.82711364
57Acute myeloid leukemia_Homo sapiens_hsa052210.81159714
58ErbB signaling pathway_Homo sapiens_hsa040120.78590647
59Phototransduction_Homo sapiens_hsa047440.78428437
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78204884
61Renin-angiotensin system_Homo sapiens_hsa046140.77878694
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75946020
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.73147034
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67568871
65Melanoma_Homo sapiens_hsa052180.65342190
66Phenylalanine metabolism_Homo sapiens_hsa003600.64402886
67VEGF signaling pathway_Homo sapiens_hsa043700.63252027
68Adherens junction_Homo sapiens_hsa045200.63169067
69Steroid biosynthesis_Homo sapiens_hsa001000.61052707
70Folate biosynthesis_Homo sapiens_hsa007900.59690274
71Inositol phosphate metabolism_Homo sapiens_hsa005620.59410572
72Herpes simplex infection_Homo sapiens_hsa051680.57406396
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54199603
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53188602
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53050658
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51921274
77Insulin resistance_Homo sapiens_hsa049310.50662415
78Fatty acid metabolism_Homo sapiens_hsa012120.49431981
79HIF-1 signaling pathway_Homo sapiens_hsa040660.48240622
80HTLV-I infection_Homo sapiens_hsa051660.47264520
81Insulin signaling pathway_Homo sapiens_hsa049100.45756099
82Proteoglycans in cancer_Homo sapiens_hsa052050.43948726
83Influenza A_Homo sapiens_hsa051640.42769118
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41963104
85Pathways in cancer_Homo sapiens_hsa052000.41535328
86Type I diabetes mellitus_Homo sapiens_hsa049400.40525386
87RNA transport_Homo sapiens_hsa030130.40375452
88p53 signaling pathway_Homo sapiens_hsa041150.40364679
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36616436
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34989655
91Base excision repair_Homo sapiens_hsa034100.34037201
92Metabolic pathways_Homo sapiens_hsa011000.33527095
93Rheumatoid arthritis_Homo sapiens_hsa053230.31803821
94Butanoate metabolism_Homo sapiens_hsa006500.31432073
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29232580
96Notch signaling pathway_Homo sapiens_hsa043300.28152603
97Thyroid cancer_Homo sapiens_hsa052160.27511734
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26844450
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.24798440
100Starch and sucrose metabolism_Homo sapiens_hsa005000.24064572

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