MRGPRD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential (GO:0019228)9.09885683
2urinary tract smooth muscle contraction (GO:0014848)8.94641572
3regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)8.92372780
4negative regulation of complement activation (GO:0045916)8.91587410
5behavioral response to pain (GO:0048266)8.61303734
6negative regulation of dendrite morphogenesis (GO:0050774)8.12600194
7bundle of His cell to Purkinje myocyte communication (GO:0086069)7.92400617
8adenosine metabolic process (GO:0046085)7.53465256
9negative regulation of protein activation cascade (GO:2000258)7.46565884
10peristalsis (GO:0030432)6.85373785
11response to pain (GO:0048265)6.62929184
12positive regulation of synaptic transmission, GABAergic (GO:0032230)6.57461446
13negative regulation of humoral immune response (GO:0002921)6.17504746
14positive regulation of muscle hypertrophy (GO:0014742)5.88900433
15positive regulation of cardiac muscle hypertrophy (GO:0010613)5.88900433
16membrane depolarization during action potential (GO:0086010)5.73227724
17negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.62361270
18phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.52742933
19negative regulation of dendrite development (GO:2000171)5.25319535
20response to ATP (GO:0033198)5.23625943
21positive regulation of amino acid transport (GO:0051957)5.10939384
22regulation of platelet aggregation (GO:0090330)5.01837070
23enteric nervous system development (GO:0048484)5.00924583
24peripheral nervous system neuron development (GO:0048935)4.80431335
25neurofilament cytoskeleton organization (GO:0060052)4.76583674
26regulation of collateral sprouting (GO:0048670)4.64321180
27proline transport (GO:0015824)4.52662316
28cellular response to prostaglandin stimulus (GO:0071379)4.49185127
29neuromuscular synaptic transmission (GO:0007274)4.48301128
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.37951124
31cell communication involved in cardiac conduction (GO:0086065)4.37576844
32detection of temperature stimulus involved in sensory perception (GO:0050961)4.33776710
33detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.33776710
34action potential (GO:0001508)4.31173389
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.17190407
36membrane repolarization (GO:0086009)4.13982504
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.12725323
38detection of temperature stimulus (GO:0016048)4.11697695
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.11615659
40regulation of sensory perception (GO:0051931)4.03337136
41regulation of sensory perception of pain (GO:0051930)4.03337136
42potassium ion export (GO:0071435)4.03223678
43regulation of homotypic cell-cell adhesion (GO:0034110)3.80348084
44acrosome reaction (GO:0007340)3.74002119
45regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.70152430
46detection of mechanical stimulus involved in sensory perception (GO:0050974)3.67992793
47phasic smooth muscle contraction (GO:0014821)3.66582352
48cellular potassium ion homeostasis (GO:0030007)3.64100902
49alanine transport (GO:0032328)3.62559165
50glycosphingolipid biosynthetic process (GO:0006688)3.60658085
51negative regulation of sodium ion transport (GO:0010766)3.59263194
52cytokine production involved in immune response (GO:0002367)3.57606459
53sodium ion transmembrane transport (GO:0035725)3.57003006
54multicellular organismal response to stress (GO:0033555)3.52823526
55synaptic vesicle maturation (GO:0016188)3.50251606
56purinergic nucleotide receptor signaling pathway (GO:0035590)3.47832894
57establishment of mitochondrion localization (GO:0051654)3.46160125
58sensory perception of taste (GO:0050909)3.44462136
59regulation of cardiac muscle hypertrophy (GO:0010611)3.41412914
60cell migration in hindbrain (GO:0021535)3.41316530
61glutamate secretion (GO:0014047)3.35766730
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.35640861
63sodium ion export (GO:0071436)3.35116142
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.30540040
65regulation of membrane depolarization (GO:0003254)3.30090542
66regulation of muscle hypertrophy (GO:0014743)3.26500671
67regulation of amyloid precursor protein catabolic process (GO:1902991)3.19096790
68dopamine receptor signaling pathway (GO:0007212)3.18088276
69negative regulation of microtubule polymerization (GO:0031115)3.15472701
70axon cargo transport (GO:0008088)3.14538080
71calcium ion-dependent exocytosis (GO:0017156)3.09882288
72vesicle transport along microtubule (GO:0047496)3.07473856
73membrane depolarization (GO:0051899)3.05535023
74sleep (GO:0030431)3.04474817
75regulation of cell communication by electrical coupling (GO:0010649)2.95629225
76glycine transport (GO:0015816)2.91471906
77regulation of amino acid transport (GO:0051955)2.90763553
78regulation of potassium ion transmembrane transporter activity (GO:1901016)2.90349827
79cellular sodium ion homeostasis (GO:0006883)2.88509759
80positive regulation of potassium ion transport (GO:0043268)2.84910962
81regulation of dopamine secretion (GO:0014059)2.83980168
82positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.83238366
83regulation of synaptic transmission, GABAergic (GO:0032228)2.80097759
84positive regulation of calcium-mediated signaling (GO:0050850)2.80002176
85organelle transport along microtubule (GO:0072384)2.79796540
86retinal ganglion cell axon guidance (GO:0031290)2.79395806
87purinergic receptor signaling pathway (GO:0035587)2.77918855
88response to cold (GO:0009409)2.76644109
89regulation of potassium ion transmembrane transport (GO:1901379)2.76584296
90membrane budding (GO:0006900)2.76028830
91positive regulation of calcium ion transport into cytosol (GO:0010524)2.75454057
92response to water (GO:0009415)2.74020720
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.71858594
94positive regulation of amine transport (GO:0051954)2.68510234
95regulation of synaptic vesicle exocytosis (GO:2000300)2.66682799
96regulation of cardiac muscle contraction (GO:0055117)2.63337740
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62777349
98mitochondrion transport along microtubule (GO:0047497)2.62777349
99neuronal action potential propagation (GO:0019227)2.61862580
100regulation of sodium ion transmembrane transporter activity (GO:2000649)2.61560601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.49345110
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.23668630
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.03014634
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81226406
5ZNF263_19887448_ChIP-Seq_K562_Human2.68669494
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48377726
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45743380
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43022824
9EGR1_19032775_ChIP-ChIP_M12_Human2.33039511
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30258850
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.30064429
12GBX2_23144817_ChIP-Seq_PC3_Human2.29255340
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28057938
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27318591
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27318591
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26028515
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.23634540
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22642036
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.16516335
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08787368
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96640546
22SMAD4_21799915_ChIP-Seq_A2780_Human1.96497176
23REST_21632747_ChIP-Seq_MESCs_Mouse1.90269498
24GATA1_22025678_ChIP-Seq_K562_Human1.86093939
25EZH2_22144423_ChIP-Seq_EOC_Human1.74443283
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.70709603
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.69821227
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67958480
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63963987
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.59323856
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55950970
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.51768734
33TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51726569
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50303987
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49389402
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48894792
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46302531
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46191005
39TAF15_26573619_Chip-Seq_HEK293_Human1.44211040
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44167445
41AHR_22903824_ChIP-Seq_MCF-7_Human1.43703396
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.38836952
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38494791
44* CTCF_27219007_Chip-Seq_Bcells_Human1.38375361
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35212726
46BCAT_22108803_ChIP-Seq_LS180_Human1.32815479
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30398471
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.29193627
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28485966
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.28283823
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.28031520
52SMAD4_21741376_ChIP-Seq_HESCs_Human1.27305347
53ZNF274_21170338_ChIP-Seq_K562_Hela1.27148172
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27049567
55* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23468275
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20619248
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19901305
58AR_21572438_ChIP-Seq_LNCaP_Human1.18816365
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.18479143
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15856318
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14553559
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.14186989
63KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.14073731
64P300_19829295_ChIP-Seq_ESCs_Human1.12887510
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.12407901
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11728408
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.10606847
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09918879
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.07469789
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03951279
71SOX2_20726797_ChIP-Seq_SW620_Human1.03564710
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.02616981
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01961792
74NANOG_19829295_ChIP-Seq_ESCs_Human1.01813250
75SOX2_19829295_ChIP-Seq_ESCs_Human1.01813250
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01563855
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01563855
78IGF1R_20145208_ChIP-Seq_DFB_Human1.01558408
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01369359
80STAT3_23295773_ChIP-Seq_U87_Human1.01065145
81AR_19668381_ChIP-Seq_PC3_Human1.00814028
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00669549
83KDM2B_26808549_Chip-Seq_K562_Human0.99881258
84DROSHA_22980978_ChIP-Seq_HELA_Human0.96776507
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96272146
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94088104
87TCF4_22108803_ChIP-Seq_LS180_Human0.93156714
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92979274
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92796424
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91863993
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91507902
92KDM2B_26808549_Chip-Seq_REH_Human0.90972877
93* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90014395
94ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89008874
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88606248
96OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87754189
97CJUN_26792858_Chip-Seq_BT549_Human0.87578448
98AR_25329375_ChIP-Seq_VCAP_Human0.87394561
99KLF4_19829295_ChIP-Seq_ESCs_Human0.86037517
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84887412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception9.36613512
2* MP0001968_abnormal_touch/_nociception8.67110233
3* MP0002736_abnormal_nociception_after7.97254983
4MP0001986_abnormal_taste_sensitivity5.15604037
5* MP0002733_abnormal_thermal_nociception4.39589660
6* MP0001970_abnormal_pain_threshold3.66745210
7* MP0002734_abnormal_mechanical_nocicepti3.56265985
8MP0004270_analgesia3.44990918
9MP0006276_abnormal_autonomic_nervous3.08044930
10MP0003656_abnormal_erythrocyte_physiolo2.93524733
11MP0004858_abnormal_nervous_system2.82752380
12* MP0002272_abnormal_nervous_system2.23655678
13MP0004859_abnormal_synaptic_plasticity1.86944671
14* MP0002067_abnormal_sensory_capabilities1.78701191
15MP0002751_abnormal_autonomic_nervous1.58640252
16MP0001270_distended_abdomen1.56387357
17MP0003329_amyloid_beta_deposits1.51205422
18MP0003635_abnormal_synaptic_transmissio1.42676628
19MP0002184_abnormal_innervation1.40403141
20MP0005083_abnormal_biliary_tract1.32971254
21MP0003806_abnormal_nucleotide_metabolis1.29563924
22MP0002837_dystrophic_cardiac_calcinosis1.25114026
23MP0004811_abnormal_neuron_physiology1.24227138
24MP0000955_abnormal_spinal_cord1.11596574
25MP0001348_abnormal_lacrimal_gland1.10995348
26MP0010234_abnormal_vibrissa_follicle1.09301610
27* MP0010771_integument_phenotype1.07643752
28MP0000604_amyloidosis1.05478122
29MP0003880_abnormal_central_pattern1.03457033
30MP0002064_seizures1.01252831
31MP0005423_abnormal_somatic_nervous0.92604294
32MP0008260_abnormal_autophagy0.91850219
33MP0001299_abnormal_eye_distance/0.91632379
34MP0002063_abnormal_learning/memory/cond0.87750275
35MP0008874_decreased_physiological_sensi0.86736337
36MP0001984_abnormal_olfaction0.82629936
37MP0004130_abnormal_muscle_cell0.82205602
38MP0009745_abnormal_behavioral_response0.81758021
39MP0003633_abnormal_nervous_system0.80314233
40MP0009046_muscle_twitch0.78995804
41MP0000579_abnormal_nail_morphology0.77296221
42MP0003045_fibrosis0.76789037
43MP0000427_abnormal_hair_cycle0.76136746
44MP0000749_muscle_degeneration0.75900273
45MP0000538_abnormal_urinary_bladder0.75227668
46MP0000747_muscle_weakness0.73084568
47MP0001727_abnormal_embryo_implantation0.72499760
48MP0002909_abnormal_adrenal_gland0.71558688
49MP0002572_abnormal_emotion/affect_behav0.69808852
50MP0004036_abnormal_muscle_relaxation0.69059582
51MP0003634_abnormal_glial_cell0.68840963
52* MP0002882_abnormal_neuron_morphology0.67207795
53MP0000534_abnormal_ureter_morphology0.66030871
54MP0000920_abnormal_myelination0.65743617
55MP0008961_abnormal_basal_metabolism0.65735434
56MP0003868_abnormal_feces_composition0.65037130
57MP0000778_abnormal_nervous_system0.65019158
58MP0003172_abnormal_lysosome_physiology0.64263643
59MP0000569_abnormal_digit_pigmentation0.63443006
60MP0003631_nervous_system_phenotype0.60366204
61MP0004185_abnormal_adipocyte_glucose0.59831205
62MP0000751_myopathy0.59384094
63MP0005464_abnormal_platelet_physiology0.58008659
64MP0001661_extended_life_span0.57638393
65MP0002066_abnormal_motor_capabilities/c0.55749410
66MP0001440_abnormal_grooming_behavior0.54334788
67MP0002972_abnormal_cardiac_muscle0.49996535
68MP0009697_abnormal_copulation0.49293067
69MP0002229_neurodegeneration0.47142042
70MP0005165_increased_susceptibility_to0.46921726
71MP0004084_abnormal_cardiac_muscle0.46138520
72MP0001664_abnormal_digestion0.45693619
73MP0009379_abnormal_foot_pigmentation0.44838484
74MP0000681_abnormal_thyroid_gland0.44204180
75MP0004215_abnormal_myocardial_fiber0.43470886
76MP0003137_abnormal_impulse_conducting0.42877789
77MP0001905_abnormal_dopamine_level0.42720084
78MP0004142_abnormal_muscle_tone0.42009656
79MP0010386_abnormal_urinary_bladder0.41030360
80MP0004085_abnormal_heartbeat0.40492817
81MP0005535_abnormal_body_temperature0.39001489
82MP0009780_abnormal_chondrocyte_physiolo0.37306270
83MP0004924_abnormal_behavior0.37191642
84MP0005386_behavior/neurological_phenoty0.37191642
85MP0002282_abnormal_trachea_morphology0.34730391
86MP0002557_abnormal_social/conspecific_i0.34052642
87MP0002269_muscular_atrophy0.33668226
88MP0003183_abnormal_peptide_metabolism0.33283282
89MP0002752_abnormal_somatic_nervous0.33035394
90MP0005584_abnormal_enzyme/coenzyme_acti0.31142606
91MP0000230_abnormal_systemic_arterial0.31127080
92MP0003300_gastrointestinal_ulcer0.30381415
93MP0008569_lethality_at_weaning0.30168311
94MP0003632_abnormal_nervous_system0.29837911
95MP0001756_abnormal_urination0.29788467
96MP0005595_abnormal_vascular_smooth0.27697193
97MP0001943_abnormal_respiration0.26960704
98MP0003075_altered_response_to0.26311253
99MP0000639_abnormal_adrenal_gland0.25406174
100MP0005187_abnormal_penis_morphology0.24854253

Predicted human phenotypes

RankGene SetZ-score
1Dysautonomia (HP:0002459)7.05745406
2Ulnar claw (HP:0001178)6.85981455
3Abnormality of pain sensation (HP:0010832)6.34157876
4Impaired pain sensation (HP:0007328)6.34157876
5Insidious onset (HP:0003587)5.58176190
6Termporal pattern (HP:0011008)5.58176190
7Pheochromocytoma (HP:0002666)4.94726629
8Segmental peripheral demyelination/remyelination (HP:0003481)4.88482724
9Action tremor (HP:0002345)4.62258596
10Neuroendocrine neoplasm (HP:0100634)4.49279122
11Myokymia (HP:0002411)4.21691927
12Hammertoe (HP:0001765)4.15870813
13Distal arthrogryposis (HP:0005684)4.04548315
14Abnormal autonomic nervous system physiology (HP:0012332)4.04452742
15Ankle clonus (HP:0011448)3.71108814
16Onion bulb formation (HP:0003383)3.64380950
17Steppage gait (HP:0003376)3.54560224
18Focal seizures (HP:0007359)3.54299264
19Foot dorsiflexor weakness (HP:0009027)3.52298255
20Hypomagnesemia (HP:0002917)3.46002944
21Failure to thrive in infancy (HP:0001531)3.44637361
22Abnormality of magnesium homeostasis (HP:0004921)3.27379844
23Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.23265764
24Thoracolumbar scoliosis (HP:0002944)3.22569627
25Distal sensory impairment (HP:0002936)3.21004708
26Supranuclear gaze palsy (HP:0000605)3.19710257
27Myotonia (HP:0002486)3.16662226
28Atonic seizures (HP:0010819)3.14290593
29Abnormality of the foot musculature (HP:0001436)3.12436575
30Irregular epiphyses (HP:0010582)3.04016101
31Hypothermia (HP:0002045)2.99399499
32Abnormality of the vocal cords (HP:0008777)2.96557515
33Potter facies (HP:0002009)2.96464308
34Facial shape deformation (HP:0011334)2.96464308
35Submucous cleft hard palate (HP:0000176)2.95157506
36Abnormality of the corticospinal tract (HP:0002492)2.92281812
37Hypoventilation (HP:0002791)2.90925698
38Urinary urgency (HP:0000012)2.85182504
39Hyporeflexia of lower limbs (HP:0002600)2.74443464
40Hypercortisolism (HP:0001578)2.71844665
41Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.71235807
42Cerebral hemorrhage (HP:0001342)2.68673871
43Bradycardia (HP:0001662)2.68660240
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68120183
45Neoplasm of the peripheral nervous system (HP:0100007)2.58375656
46Visual hallucinations (HP:0002367)2.57334865
47Torticollis (HP:0000473)2.55988573
48Aplasia/Hypoplasia of the brainstem (HP:0007362)2.35763823
49Hypoplasia of the brainstem (HP:0002365)2.35763823
50Ventricular fibrillation (HP:0001663)2.35758829
51Peripheral hypomyelination (HP:0007182)2.35460352
52Spastic gait (HP:0002064)2.34775597
53Abnormality of the ischium (HP:0003174)2.33381681
54Axonal loss (HP:0003447)2.29559924
55Dialeptic seizures (HP:0011146)2.27917511
56Decreased motor nerve conduction velocity (HP:0003431)2.27801872
57Areflexia of lower limbs (HP:0002522)2.26772366
58Clonus (HP:0002169)2.26336118
59Impaired proprioception (HP:0010831)2.25377316
60Anosmia (HP:0000458)2.23275732
61Febrile seizures (HP:0002373)2.18162158
62Chin dimple (HP:0010751)2.17158417
63Lower limb muscle weakness (HP:0007340)2.16953807
64Craniofacial dystonia (HP:0012179)2.16685658
65Thyroid carcinoma (HP:0002890)2.16597422
66Overlapping toe (HP:0001845)2.11880696
67Absence seizures (HP:0002121)2.10190256
68Abnormality of the lower motor neuron (HP:0002366)2.08870956
69Urinary bladder sphincter dysfunction (HP:0002839)2.08098473
70Abnormality of calcium-phosphate metabolism (HP:0100530)2.07803697
71Postural tremor (HP:0002174)2.04973914
72Abnormality of the parathyroid morphology (HP:0011766)2.04034825
73Absent phalangeal crease (HP:0006109)2.00331038
74Adducted thumb (HP:0001181)1.99253793
75Bowel diverticulosis (HP:0005222)1.99024886
76Focal dystonia (HP:0004373)1.98279759
77Hand muscle atrophy (HP:0009130)1.97396749
78Paraplegia (HP:0010550)1.95529613
79Neonatal onset (HP:0003623)1.93760478
80Generalized tonic-clonic seizures (HP:0002069)1.93184301
81Knee flexion contracture (HP:0006380)1.92004267
82Autoamputation (HP:0001218)1.91304773
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90830071
84Abnormality of femoral epiphyses (HP:0006499)1.90830071
85Progressive cerebellar ataxia (HP:0002073)1.90186139
86Lower limb asymmetry (HP:0100559)1.88168256
87Lumbar hyperlordosis (HP:0002938)1.87163552
88Increased CSF protein (HP:0002922)1.86561284
89Aqueductal stenosis (HP:0002410)1.85655544
90Abnormality of the epiphysis of the femoral head (HP:0010574)1.84596641
91Peripheral demyelination (HP:0011096)1.84517810
92Rapidly progressive (HP:0003678)1.82310988
93Neuroblastic tumors (HP:0004376)1.81585768
94Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.81585768
95Neuroblastoma (HP:0003006)1.81585768
96Primitive neuroectodermal tumor (HP:0030065)1.81585768
97Spastic paraplegia (HP:0001258)1.81096591
98Papilledema (HP:0001085)1.79095078
99Mask-like facies (HP:0000298)1.78409237
100Glomerulonephritis (HP:0000099)1.78008824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.12101261
2MAP3K94.54482466
3KSR23.76949992
4MARK33.22568453
5GRK53.18201080
6MAP3K22.92887738
7LIMK12.67819527
8MINK12.64920831
9LMTK22.54272776
10NTRK12.47931957
11DAPK22.44722118
12RET2.35824218
13NTRK32.28142051
14MAP3K122.07475268
15ARAF2.02854356
16EPHA31.99072428
17PAK61.85083247
18PRKD31.82286438
19FRK1.55659626
20LATS21.48975712
21MAP2K41.44018199
22MAP3K11.42520519
23PRKG21.39215826
24MAP2K11.33247541
25RPS6KA21.29749220
26YES11.27347934
27CAMKK21.18813983
28SGK4941.10810855
29SGK2231.10810855
30FER1.09340705
31PHKG21.06052861
32PHKG11.06052861
33PDK11.04627106
34EPHB11.04616813
35CDK141.02191797
36FLT31.01259614
37CDK50.99687139
38NEK10.99088040
39MAP3K40.94779695
40PTK20.92470674
41FGFR30.91010993
42UHMK10.85730753
43FGFR20.83701138
44MAP2K70.83063930
45MAP2K20.80568448
46PRKCZ0.78425492
47PINK10.76922234
48MET0.76799423
49PDPK10.72599151
50SGK20.71679177
51FGFR40.71225176
52SCYL20.69946386
53PAK30.65653547
54CAMKK10.64834819
55CSNK1G20.64286613
56STK390.61065675
57SIK30.59588256
58KSR10.59495130
59DAPK10.58716127
60MAP3K130.55113977
61MAP3K110.54369715
62PDGFRB0.51768074
63JAK10.51469031
64PTK2B0.49597811
65CSNK1A1L0.48743862
66PRKCH0.47984881
67CAMK2A0.47851423
68CSNK1G30.47195885
69RAF10.47149720
70SGK30.46779282
71PLK20.45916535
72MATK0.45850582
73WNK10.45224123
74PDGFRA0.45113487
75ADRBK10.44932919
76HIPK20.44340689
77CAMK2D0.41628008
78DYRK20.41490996
79MARK10.41321804
80CDC42BPA0.40357008
81PRKCG0.39680459
82PRKCE0.39538422
83JAK20.37838545
84PRKCD0.37365763
85WNK40.37004859
86CDK180.36044090
87MAPK100.35349723
88TRPM70.33691597
89MAPK40.33570956
90FYN0.33557097
91LRRK20.33553474
92ROCK10.33348199
93PRKCA0.32994986
94PDK40.32851158
95PDK30.32851158
96SRC0.32351653
97AURKA0.31037221
98BLK0.30630727
99MAPKAPK30.30380573
100CDK150.30208045

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.01077262
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.99530714
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.54554643
4Synaptic vesicle cycle_Homo sapiens_hsa047212.89275245
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.63238179
6Insulin secretion_Homo sapiens_hsa049112.09382296
7Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.94040292
8Steroid biosynthesis_Homo sapiens_hsa001001.88999305
9Taste transduction_Homo sapiens_hsa047421.84904348
10Salivary secretion_Homo sapiens_hsa049701.60919083
11Thyroid cancer_Homo sapiens_hsa052161.58621656
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57625224
13Long-term potentiation_Homo sapiens_hsa047201.57515589
14Glutamatergic synapse_Homo sapiens_hsa047241.55132789
15Olfactory transduction_Homo sapiens_hsa047401.49884358
16Dopaminergic synapse_Homo sapiens_hsa047281.47040681
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45803554
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42901557
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39585454
20Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.38703738
21Dorso-ventral axis formation_Homo sapiens_hsa043201.35858421
22Cholinergic synapse_Homo sapiens_hsa047251.33333479
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.31716490
24Glycerolipid metabolism_Homo sapiens_hsa005611.29976769
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27301184
26Circadian entrainment_Homo sapiens_hsa047131.25496429
27GnRH signaling pathway_Homo sapiens_hsa049121.25267740
28Thyroid hormone synthesis_Homo sapiens_hsa049181.20774937
29Mineral absorption_Homo sapiens_hsa049781.20083351
30Collecting duct acid secretion_Homo sapiens_hsa049661.15982772
31Glioma_Homo sapiens_hsa052141.15496407
32Vibrio cholerae infection_Homo sapiens_hsa051101.15034737
33Long-term depression_Homo sapiens_hsa047301.13689878
34Pancreatic secretion_Homo sapiens_hsa049721.13032568
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12481877
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11304105
37Choline metabolism in cancer_Homo sapiens_hsa052311.09685794
38Cardiac muscle contraction_Homo sapiens_hsa042601.07047134
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06937800
40Bile secretion_Homo sapiens_hsa049761.06448814
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04087890
42Serotonergic synapse_Homo sapiens_hsa047261.02287034
43Gap junction_Homo sapiens_hsa045401.02107645
44Gastric acid secretion_Homo sapiens_hsa049710.99342718
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.97745507
46VEGF signaling pathway_Homo sapiens_hsa043700.95695407
47GABAergic synapse_Homo sapiens_hsa047270.94809951
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93662568
49Calcium signaling pathway_Homo sapiens_hsa040200.92462449
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.90853974
51Melanogenesis_Homo sapiens_hsa049160.90598746
52Type II diabetes mellitus_Homo sapiens_hsa049300.90355415
53Salmonella infection_Homo sapiens_hsa051320.89336419
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.88155279
55mTOR signaling pathway_Homo sapiens_hsa041500.85302911
56Protein digestion and absorption_Homo sapiens_hsa049740.83784007
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.83344391
58Estrogen signaling pathway_Homo sapiens_hsa049150.83283149
59Phagosome_Homo sapiens_hsa041450.81604115
60Melanoma_Homo sapiens_hsa052180.81426146
61Viral myocarditis_Homo sapiens_hsa054160.81144849
62Insulin signaling pathway_Homo sapiens_hsa049100.80830981
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77500872
64ErbB signaling pathway_Homo sapiens_hsa040120.75243981
65Morphine addiction_Homo sapiens_hsa050320.75124754
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.74572181
67Rap1 signaling pathway_Homo sapiens_hsa040150.74571084
68African trypanosomiasis_Homo sapiens_hsa051430.73267941
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73010772
70Endometrial cancer_Homo sapiens_hsa052130.71369415
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70829150
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69365094
73Oxytocin signaling pathway_Homo sapiens_hsa049210.68746767
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66126478
75Amoebiasis_Homo sapiens_hsa051460.64333733
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63156189
77Complement and coagulation cascades_Homo sapiens_hsa046100.63121958
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62743742
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60772535
80Endocytosis_Homo sapiens_hsa041440.59740551
81Oocyte meiosis_Homo sapiens_hsa041140.58207869
82Nicotine addiction_Homo sapiens_hsa050330.57610552
83Regulation of autophagy_Homo sapiens_hsa041400.57172786
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57029980
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55897545
86Prolactin signaling pathway_Homo sapiens_hsa049170.51199852
87Amphetamine addiction_Homo sapiens_hsa050310.50980200
88Axon guidance_Homo sapiens_hsa043600.50642790
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48499022
90Renin secretion_Homo sapiens_hsa049240.44218433
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43799326
92Pyruvate metabolism_Homo sapiens_hsa006200.43768615
93Prion diseases_Homo sapiens_hsa050200.41651935
94Shigellosis_Homo sapiens_hsa051310.39267685
95Non-small cell lung cancer_Homo sapiens_hsa052230.39010261
96Bladder cancer_Homo sapiens_hsa052190.37250071
97Fatty acid elongation_Homo sapiens_hsa000620.36166042
98Caffeine metabolism_Homo sapiens_hsa002320.35184403
99Butanoate metabolism_Homo sapiens_hsa006500.34608409
100Ras signaling pathway_Homo sapiens_hsa040140.33064291

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