MRFAP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.26083435
2nucleobase catabolic process (GO:0046113)4.89538372
3neuron cell-cell adhesion (GO:0007158)4.70497405
4presynaptic membrane assembly (GO:0097105)4.04434730
5establishment of mitochondrion localization (GO:0051654)3.82652915
6positive regulation of mitochondrial fission (GO:0090141)3.80937495
7sequestering of actin monomers (GO:0042989)3.78632893
8presynaptic membrane organization (GO:0097090)3.76051561
9vocalization behavior (GO:0071625)3.75357257
10gamma-aminobutyric acid transport (GO:0015812)3.75164144
11DNA double-strand break processing (GO:0000729)3.68678811
12negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.61195493
13nonmotile primary cilium assembly (GO:0035058)3.56715186
14postsynaptic membrane organization (GO:0001941)3.53612650
15neural tube formation (GO:0001841)3.47396386
16protein localization to cilium (GO:0061512)3.43378793
17regulation of synaptic vesicle exocytosis (GO:2000300)3.33882893
18ubiquinone metabolic process (GO:0006743)3.33265496
19DNA damage response, detection of DNA damage (GO:0042769)3.29716008
20axonal fasciculation (GO:0007413)3.27910256
21hippocampus development (GO:0021766)3.25999528
22intraciliary transport (GO:0042073)3.25845641
23regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.25555870
24protein localization to synapse (GO:0035418)3.25403046
25synapse assembly (GO:0007416)3.22377811
26neuron recognition (GO:0008038)3.19110395
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.18628507
28synaptic vesicle maturation (GO:0016188)3.16528221
29behavioral response to nicotine (GO:0035095)3.10048151
30cerebral cortex radially oriented cell migration (GO:0021799)3.07656778
31glycosphingolipid biosynthetic process (GO:0006688)3.04813374
32cullin deneddylation (GO:0010388)3.03469968
33limb bud formation (GO:0060174)3.03247602
34forebrain neuron differentiation (GO:0021879)3.01940905
35ribonucleoprotein complex disassembly (GO:0032988)2.96647995
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95782080
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95782080
38calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.94315728
39negative regulation of oligodendrocyte differentiation (GO:0048715)2.94106847
40ubiquinone biosynthetic process (GO:0006744)2.93388739
41auditory behavior (GO:0031223)2.92279880
42protein deneddylation (GO:0000338)2.91248275
43regulation of synaptic vesicle transport (GO:1902803)2.90946484
44negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89902501
45protein-cofactor linkage (GO:0018065)2.87924226
46neurotransmitter-gated ion channel clustering (GO:0072578)2.86078842
47regulation of development, heterochronic (GO:0040034)2.84043672
48proteasome assembly (GO:0043248)2.83823524
49glutamate receptor signaling pathway (GO:0007215)2.83629790
50transmission of nerve impulse (GO:0019226)2.81519310
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81064391
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77137186
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76818442
54positive regulation of oligodendrocyte differentiation (GO:0048714)2.76220544
55histone H2A acetylation (GO:0043968)2.73826718
56retinal ganglion cell axon guidance (GO:0031290)2.73022317
57organelle disassembly (GO:1903008)2.71750625
58cell migration in hindbrain (GO:0021535)2.71591114
59neurofilament cytoskeleton organization (GO:0060052)2.70805814
60regulation of cilium movement (GO:0003352)2.69538615
61synaptic transmission, glutamatergic (GO:0035249)2.69215551
62neurotransmitter secretion (GO:0007269)2.68643082
63olfactory bulb development (GO:0021772)2.68570919
64synaptic vesicle exocytosis (GO:0016079)2.68548035
65negative regulation of DNA recombination (GO:0045910)2.68459487
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65389130
67response to pheromone (GO:0019236)2.64638506
68regulation of mRNA splicing, via spliceosome (GO:0048024)2.63395089
69chaperone-mediated protein transport (GO:0072321)2.62041824
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59654877
71anterograde axon cargo transport (GO:0008089)2.58567731
72cytoskeleton-dependent intracellular transport (GO:0030705)2.57700208
73peptidyl-cysteine modification (GO:0018198)2.56268610
74positive regulation of synapse assembly (GO:0051965)2.55028193
75protein complex biogenesis (GO:0070271)2.54835958
76startle response (GO:0001964)2.54629010
77regulation of synapse structural plasticity (GO:0051823)2.54185802
78neuronal action potential propagation (GO:0019227)2.53281375
79establishment of melanosome localization (GO:0032401)2.50246398
80microtubule-based transport (GO:0010970)2.49943343
81mitochondrion transport along microtubule (GO:0047497)2.48500403
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48500403
83neuron-neuron synaptic transmission (GO:0007270)2.48291866
84central nervous system projection neuron axonogenesis (GO:0021952)2.47544479
85short-term memory (GO:0007614)2.47375301
86protein neddylation (GO:0045116)2.47044565
87regulation of oligodendrocyte differentiation (GO:0048713)2.46998249
88glial cell proliferation (GO:0014009)2.46269234
89mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.46192231
90positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46192231
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45269394
92mechanosensory behavior (GO:0007638)2.45138236
93de novo posttranslational protein folding (GO:0051084)2.44481144
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42654551
95amino acid salvage (GO:0043102)2.41996218
96L-methionine salvage (GO:0071267)2.41996218
97L-methionine biosynthetic process (GO:0071265)2.41996218
98somite development (GO:0061053)2.41617272
99mRNA splice site selection (GO:0006376)2.40227600
100dendrite morphogenesis (GO:0048813)2.40056303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.29785598
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12536236
3ZNF274_21170338_ChIP-Seq_K562_Hela2.98951545
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91958214
5EZH2_22144423_ChIP-Seq_EOC_Human2.82177083
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76692237
7IGF1R_20145208_ChIP-Seq_DFB_Human2.76150370
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.71877095
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56007525
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55842905
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50143589
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48646750
13TAF15_26573619_Chip-Seq_HEK293_Human2.41047427
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40725306
15GBX2_23144817_ChIP-Seq_PC3_Human2.38539525
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35485193
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.32924224
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13255698
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10901053
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04371151
21FUS_26573619_Chip-Seq_HEK293_Human2.02487263
22EWS_26573619_Chip-Seq_HEK293_Human2.01911663
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.00763843
24VDR_22108803_ChIP-Seq_LS180_Human1.94587778
25RNF2_27304074_Chip-Seq_NSC_Mouse1.88821180
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.84277440
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79831527
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77350505
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74423041
30ELK1_19687146_ChIP-ChIP_HELA_Human1.69185041
31P300_19829295_ChIP-Seq_ESCs_Human1.66929044
32REST_21632747_ChIP-Seq_MESCs_Mouse1.66660864
33* VDR_23849224_ChIP-Seq_CD4+_Human1.62369363
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.59739847
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54476644
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53155443
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50018194
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49613930
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.48654123
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47181547
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.46799429
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46778331
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44516275
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44253241
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42630577
46IRF1_19129219_ChIP-ChIP_H3396_Human1.41731374
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40504062
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36828117
49FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36354122
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32577100
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.30869354
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30854381
53CBP_20019798_ChIP-Seq_JUKART_Human1.29063074
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29063074
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28733909
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27735523
57MYC_18940864_ChIP-ChIP_HL60_Human1.25835917
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24661707
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22391023
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21399901
61* GABP_19822575_ChIP-Seq_HepG2_Human1.21187304
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21130460
63SMAD4_21799915_ChIP-Seq_A2780_Human1.19884258
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13903199
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.13506233
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13354532
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13147196
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.11010891
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10802735
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09787848
71FOXP3_21729870_ChIP-Seq_TREG_Human1.09384320
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09374072
73ER_23166858_ChIP-Seq_MCF-7_Human1.08900534
74TP53_22573176_ChIP-Seq_HFKS_Human1.08855742
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.08436255
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.08332196
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.06782080
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06702880
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06602852
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06081507
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05453734
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04937619
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03314587
84AR_25329375_ChIP-Seq_VCAP_Human1.03156604
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00847431
86RUNX2_22187159_ChIP-Seq_PCA_Human0.96331735
87NANOG_18555785_Chip-Seq_ESCs_Mouse0.95755801
88SOX9_26525672_Chip-Seq_HEART_Mouse0.94223584
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.94099305
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.94087455
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.94036682
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93646173
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91194473
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90519134
95JUN_21703547_ChIP-Seq_K562_Human0.89277335
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89271151
97STAT3_23295773_ChIP-Seq_U87_Human0.88404610
98DCP1A_22483619_ChIP-Seq_HELA_Human0.88251497
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88249753
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88023313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.68158384
2MP0001529_abnormal_vocalization3.20493377
3MP0003122_maternal_imprinting3.17564841
4MP0004859_abnormal_synaptic_plasticity2.89284596
5MP0001984_abnormal_olfaction2.48544769
6MP0001188_hyperpigmentation2.46938147
7MP0004270_analgesia2.46454008
8MP0003121_genomic_imprinting2.42918287
9MP0002736_abnormal_nociception_after2.41263235
10MP0005499_abnormal_olfactory_system2.34449736
11MP0005394_taste/olfaction_phenotype2.34449736
12MP0000778_abnormal_nervous_system2.32172694
13MP0008789_abnormal_olfactory_epithelium2.29354998
14MP0002102_abnormal_ear_morphology2.29117355
15MP0003787_abnormal_imprinting2.18873443
16MP0001968_abnormal_touch/_nociception2.17551895
17MP0008877_abnormal_DNA_methylation2.16198094
18MP0003635_abnormal_synaptic_transmissio2.13271444
19MP0005645_abnormal_hypothalamus_physiol2.09725816
20MP0005423_abnormal_somatic_nervous2.07318900
21MP0002822_catalepsy2.07180772
22MP0006276_abnormal_autonomic_nervous2.04409794
23MP0002272_abnormal_nervous_system1.91658550
24MP0002063_abnormal_learning/memory/cond1.90320788
25MP0009745_abnormal_behavioral_response1.89060078
26MP0009046_muscle_twitch1.87945431
27MP0008995_early_reproductive_senescence1.84270189
28MP0002638_abnormal_pupillary_reflex1.73403607
29MP0005646_abnormal_pituitary_gland1.71905752
30MP0002734_abnormal_mechanical_nocicepti1.67904790
31MP0002572_abnormal_emotion/affect_behav1.63683545
32MP0002735_abnormal_chemical_nociception1.63221274
33MP0001486_abnormal_startle_reflex1.59133659
34MP0002064_seizures1.55857781
35MP0004142_abnormal_muscle_tone1.55442720
36MP0004885_abnormal_endolymph1.55415603
37MP0004133_heterotaxia1.52911171
38MP0000955_abnormal_spinal_cord1.51052749
39MP0003011_delayed_dark_adaptation1.50325491
40MP0006072_abnormal_retinal_apoptosis1.49232553
41MP0002184_abnormal_innervation1.49121557
42MP0000631_abnormal_neuroendocrine_gland1.48438281
43MP0000049_abnormal_middle_ear1.43722971
44MP0004811_abnormal_neuron_physiology1.43336984
45MP0002234_abnormal_pharynx_morphology1.43034380
46MP0006292_abnormal_olfactory_placode1.42093217
47MP0002557_abnormal_social/conspecific_i1.42026566
48MP0005253_abnormal_eye_physiology1.40587649
49MP0002653_abnormal_ependyma_morphology1.36446725
50MP0002067_abnormal_sensory_capabilities1.31592931
51MP0002751_abnormal_autonomic_nervous1.31148445
52MP0002882_abnormal_neuron_morphology1.29280950
53MP0005386_behavior/neurological_phenoty1.29179982
54MP0004924_abnormal_behavior1.29179982
55MP0003221_abnormal_cardiomyocyte_apopto1.27255411
56MP0001905_abnormal_dopamine_level1.21939684
57MP0003938_abnormal_ear_development1.21767318
58MP0008058_abnormal_DNA_repair1.19723902
59MP0003567_abnormal_fetal_cardiomyocyte1.19595311
60MP0005551_abnormal_eye_electrophysiolog1.18190887
61MP0004147_increased_porphyrin_level1.15859289
62MP0001970_abnormal_pain_threshold1.12165959
63MP0002752_abnormal_somatic_nervous1.11724845
64MP0003119_abnormal_digestive_system1.09008594
65MP0001502_abnormal_circadian_rhythm1.08559676
66MP0002152_abnormal_brain_morphology1.08274862
67MP0000566_synostosis1.08052189
68MP0001177_atelectasis1.07643096
69MP0002733_abnormal_thermal_nociception1.02762168
70MP0004742_abnormal_vestibular_system1.02481479
71MP0002233_abnormal_nose_morphology1.01885410
72MP0005187_abnormal_penis_morphology1.01270633
73MP0002066_abnormal_motor_capabilities/c0.99351638
74MP0003861_abnormal_nervous_system0.96307973
75MP0006035_abnormal_mitochondrial_morpho0.96133262
76MP0001986_abnormal_taste_sensitivity0.95798912
77MP0002909_abnormal_adrenal_gland0.95447054
78MP0003937_abnormal_limbs/digits/tail_de0.92565568
79MP0001293_anophthalmia0.90218577
80MP0000026_abnormal_inner_ear0.89888293
81MP0003890_abnormal_embryonic-extraembry0.88803845
82MP0002069_abnormal_eating/drinking_beha0.87957521
83MP0005084_abnormal_gallbladder_morpholo0.86628093
84MP0005391_vision/eye_phenotype0.84509855
85MP0000647_abnormal_sebaceous_gland0.83289092
86MP0001299_abnormal_eye_distance/0.82431918
87MP0002229_neurodegeneration0.79039145
88MP0001963_abnormal_hearing_physiology0.76719681
89MP0003755_abnormal_palate_morphology0.76005310
90MP0005248_abnormal_Harderian_gland0.73616626
91MP0003137_abnormal_impulse_conducting0.69584506
92MP0005195_abnormal_posterior_eye0.69403109
93MP0008569_lethality_at_weaning0.68187039
94MP0001270_distended_abdomen0.66876623
95MP0003698_abnormal_male_reproductive0.65593816
96MP0002210_abnormal_sex_determination0.63368708
97MP0010386_abnormal_urinary_bladder0.62599030
98MP0003786_premature_aging0.62422813
99MP0001764_abnormal_homeostasis0.61053605
100MP0002081_perinatal_lethality0.60648511

Predicted human phenotypes

RankGene SetZ-score
1Gait imbalance (HP:0002141)3.92561889
2Medial flaring of the eyebrow (HP:0010747)3.64039046
3Congenital primary aphakia (HP:0007707)3.60598148
4Nephrogenic diabetes insipidus (HP:0009806)3.55504397
5Abnormality of the labia minora (HP:0012880)3.23506697
6Amyotrophic lateral sclerosis (HP:0007354)3.21948220
7Cortical dysplasia (HP:0002539)3.18052684
8True hermaphroditism (HP:0010459)3.08805109
9Polyphagia (HP:0002591)3.04519746
10Myokymia (HP:0002411)3.04406007
11Genital tract atresia (HP:0001827)2.93828331
12Vaginal atresia (HP:0000148)2.92379568
13Drooling (HP:0002307)2.90623264
14Limb dystonia (HP:0002451)2.90437902
15Atrophy/Degeneration involving motor neurons (HP:0007373)2.82208039
16Hyperglycinemia (HP:0002154)2.72127465
17Excessive salivation (HP:0003781)2.67911084
18Focal motor seizures (HP:0011153)2.65836081
19Pancreatic cysts (HP:0001737)2.65135347
20Lissencephaly (HP:0001339)2.64651534
21Pancreatic fibrosis (HP:0100732)2.57728975
22Specific learning disability (HP:0001328)2.57282041
23Poor suck (HP:0002033)2.55987024
24Thyroid-stimulating hormone excess (HP:0002925)2.46223986
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44013473
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.44013473
27Methylmalonic acidemia (HP:0002912)2.42939688
28Acute necrotizing encephalopathy (HP:0006965)2.42712866
29Abnormality of the corticospinal tract (HP:0002492)2.42507043
30Abnormality of the lower motor neuron (HP:0002366)2.40396618
31Poor coordination (HP:0002370)2.39000583
32Urinary urgency (HP:0000012)2.35753532
33Split foot (HP:0001839)2.31496757
34Shoulder girdle muscle weakness (HP:0003547)2.30293246
35Broad-based gait (HP:0002136)2.29238485
36Abnormal mitochondria in muscle tissue (HP:0008316)2.23664761
37Intestinal atresia (HP:0011100)2.22970621
38Focal seizures (HP:0007359)2.22559812
39Pachygyria (HP:0001302)2.21214610
40Decreased testicular size (HP:0008734)2.17304374
41Atonic seizures (HP:0010819)2.16860106
42Epileptic encephalopathy (HP:0200134)2.15823754
43Increased hepatocellular lipid droplets (HP:0006565)2.14850271
44Hyperventilation (HP:0002883)2.14569955
45Dyskinesia (HP:0100660)2.13773330
46Tubulointerstitial nephritis (HP:0001970)2.13753097
47Nephronophthisis (HP:0000090)2.12660095
48Retinal dysplasia (HP:0007973)2.12495699
49Progressive macrocephaly (HP:0004481)2.11015214
50Acute encephalopathy (HP:0006846)2.09777456
51Mitochondrial inheritance (HP:0001427)2.08415573
52Molar tooth sign on MRI (HP:0002419)2.08067735
53Abnormality of midbrain morphology (HP:0002418)2.08067735
54Abnormality of the musculature of the pelvis (HP:0001469)2.07619685
55Abnormality of the hip-girdle musculature (HP:0001445)2.07619685
56Postaxial hand polydactyly (HP:0001162)2.05504191
57Failure to thrive in infancy (HP:0001531)2.05438135
58Broad foot (HP:0001769)2.04216775
593-Methylglutaconic aciduria (HP:0003535)2.02404468
60Cerebral hypomyelination (HP:0006808)2.01487373
61Increased CSF lactate (HP:0002490)2.01322834
62Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00113323
63Hypoplasia of the brainstem (HP:0002365)2.00113323
64Impaired vibration sensation in the lower limbs (HP:0002166)1.99645223
65Progressive inability to walk (HP:0002505)1.99382247
66Absent speech (HP:0001344)1.99349115
67Febrile seizures (HP:0002373)1.99120931
68Abnormality of the anterior horn cell (HP:0006802)1.97369998
69Degeneration of anterior horn cells (HP:0002398)1.97369998
70Muscular hypotonia of the trunk (HP:0008936)1.96659497
71Volvulus (HP:0002580)1.93324763
72CNS hypomyelination (HP:0003429)1.92479406
73Hypsarrhythmia (HP:0002521)1.90696534
74Spastic tetraplegia (HP:0002510)1.89557952
75Spastic gait (HP:0002064)1.89540774
76Esotropia (HP:0000565)1.89338014
77Neonatal respiratory distress (HP:0002643)1.86632307
78Morphological abnormality of the pyramidal tract (HP:0002062)1.86412104
79Lipid accumulation in hepatocytes (HP:0006561)1.85895250
80Occipital encephalocele (HP:0002085)1.85118264
81Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82370277
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82370277
83EEG with generalized epileptiform discharges (HP:0011198)1.81178257
84Hepatocellular necrosis (HP:0001404)1.79938533
85Abnormal eating behavior (HP:0100738)1.79919667
86Ankle clonus (HP:0011448)1.79241613
87Aplasia/hypoplasia of the uterus (HP:0008684)1.79192549
88Epileptiform EEG discharges (HP:0011182)1.78727223
89Short tibia (HP:0005736)1.78661607
90Postnatal microcephaly (HP:0005484)1.78415650
91Sclerocornea (HP:0000647)1.77372486
92Postaxial foot polydactyly (HP:0001830)1.76976774
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75771891
94Abnormality of alanine metabolism (HP:0010916)1.75771891
95Hyperalaninemia (HP:0003348)1.75771891
96Inability to walk (HP:0002540)1.74725525
97Renal cortical cysts (HP:0000803)1.74317531
98Anencephaly (HP:0002323)1.74232766
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73747358
100Methylmalonic aciduria (HP:0012120)1.71510759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.14577905
2MARK14.08910129
3CASK3.38633042
4MAP3K43.16017423
5TRIM283.13815134
6MAP2K72.84667905
7MAP4K22.70598876
8SRPK12.68773309
9WNK32.66193688
10ERBB32.52099914
11MAPK132.30643366
12EPHA42.22347496
13DYRK22.18277549
14CSNK1G21.82634423
15MINK11.74684875
16CSNK1G31.67852258
17PINK11.67786707
18TSSK61.57912790
19SIK31.55446388
20PLK21.52727910
21TNIK1.51010034
22NTRK21.50080713
23UHMK11.45780463
24CSNK1A1L1.43755640
25CSNK1G11.42319011
26BCKDK1.40805998
27EPHA31.38574447
28STK161.38419762
29SIK21.38185842
30DYRK31.35282979
31RPS6KA41.24295653
32PRKCG1.21011086
33CDK191.10592799
34LIMK11.06275777
35MAP2K41.04810387
36BMPR1B1.04180768
37PAK31.01839611
38MKNK10.99085120
39EIF2AK10.97450282
40KSR10.96516910
41NTRK30.95484402
42NEK10.90752894
43PAK60.89555287
44MKNK20.88337902
45DYRK1B0.85701783
46DYRK1A0.84213405
47VRK10.83637778
48PLK40.82140563
49CDK50.81841661
50PLK30.80995423
51PRKCE0.80217917
52CDK140.74515834
53EIF2AK30.72319846
54CCNB10.71910012
55TESK10.68328376
56CAMK2A0.67577038
57CAMK2B0.64391136
58CDK180.63033943
59SGK4940.62856016
60SGK2230.62856016
61ADRBK20.61924351
62CAMKK20.61830988
63PKN10.59006562
64GRK10.57327198
65CSNK1A10.55199346
66MAP3K120.55195862
67MAP3K50.55038595
68CSNK1E0.52745121
69TESK20.51062679
70CDK150.50610766
71RPS6KA50.50132675
72STK38L0.50073553
73PHKG20.48480375
74PHKG10.48480375
75WNK40.47850552
76PLK10.47191399
77CDK11A0.47118924
78PRKCZ0.46798329
79NUAK10.46269188
80STK390.46033143
81CSNK1D0.44629857
82DAPK20.41837834
83INSRR0.40526894
84ZAK0.39179376
85SGK20.37847442
86PRKD30.37712034
87PRKACB0.37570330
88OXSR10.36921536
89PRKACA0.36111322
90NME10.35865758
91BRD40.34157958
92TAOK30.32958980
93GRK70.32059979
94CSNK2A10.30563069
95ATM0.30390217
96CAMK2G0.29447975
97PNCK0.29271642
98EPHB20.28978635
99CAMKK10.28437842
100AURKA0.28282617

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.56823041
2Protein export_Homo sapiens_hsa030603.44487883
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73193681
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.72164341
5Oxidative phosphorylation_Homo sapiens_hsa001902.66771652
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45314503
7Parkinsons disease_Homo sapiens_hsa050122.30482457
8GABAergic synapse_Homo sapiens_hsa047272.22691734
9Synaptic vesicle cycle_Homo sapiens_hsa047212.09906651
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01058561
11Collecting duct acid secretion_Homo sapiens_hsa049661.93111090
12Steroid biosynthesis_Homo sapiens_hsa001001.92209477
13Butanoate metabolism_Homo sapiens_hsa006501.90621326
14Proteasome_Homo sapiens_hsa030501.90092782
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84162850
16Spliceosome_Homo sapiens_hsa030401.82904121
17Phototransduction_Homo sapiens_hsa047441.77770238
18RNA polymerase_Homo sapiens_hsa030201.77260346
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73149045
20Basal transcription factors_Homo sapiens_hsa030221.61070732
21Morphine addiction_Homo sapiens_hsa050321.57711306
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55052744
23Huntingtons disease_Homo sapiens_hsa050161.54834644
24Propanoate metabolism_Homo sapiens_hsa006401.52896400
25Dopaminergic synapse_Homo sapiens_hsa047281.52378573
26Glutamatergic synapse_Homo sapiens_hsa047241.46433607
27Alzheimers disease_Homo sapiens_hsa050101.44491956
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39391021
29Circadian entrainment_Homo sapiens_hsa047131.36723669
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33667988
31Cocaine addiction_Homo sapiens_hsa050301.30850460
32Amphetamine addiction_Homo sapiens_hsa050311.29603188
33RNA degradation_Homo sapiens_hsa030181.26974254
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26647585
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23860764
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21253547
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18788341
38Non-homologous end-joining_Homo sapiens_hsa034501.18019676
39Taste transduction_Homo sapiens_hsa047421.15129726
40RNA transport_Homo sapiens_hsa030131.14561397
41Cardiac muscle contraction_Homo sapiens_hsa042601.12510971
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12112936
43Oocyte meiosis_Homo sapiens_hsa041141.12082766
44Vibrio cholerae infection_Homo sapiens_hsa051101.11188516
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11043742
46Fatty acid elongation_Homo sapiens_hsa000621.06860608
47Regulation of autophagy_Homo sapiens_hsa041401.03366398
48Fanconi anemia pathway_Homo sapiens_hsa034601.02222038
49Axon guidance_Homo sapiens_hsa043601.01913371
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01886355
51Peroxisome_Homo sapiens_hsa041461.00081945
52mRNA surveillance pathway_Homo sapiens_hsa030150.98829436
53Base excision repair_Homo sapiens_hsa034100.98109094
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97756283
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97442146
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87732515
57Mismatch repair_Homo sapiens_hsa034300.87069307
58Circadian rhythm_Homo sapiens_hsa047100.83683572
59Serotonergic synapse_Homo sapiens_hsa047260.81172566
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76949030
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76632928
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76278083
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.75564099
64Nucleotide excision repair_Homo sapiens_hsa034200.71920880
65beta-Alanine metabolism_Homo sapiens_hsa004100.68333798
66Cholinergic synapse_Homo sapiens_hsa047250.67976184
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63467536
68Olfactory transduction_Homo sapiens_hsa047400.61776233
69Alcoholism_Homo sapiens_hsa050340.61176089
70Ether lipid metabolism_Homo sapiens_hsa005650.61043574
71Purine metabolism_Homo sapiens_hsa002300.59122740
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58940681
73Long-term depression_Homo sapiens_hsa047300.58844170
74Folate biosynthesis_Homo sapiens_hsa007900.58827228
75Selenocompound metabolism_Homo sapiens_hsa004500.58579028
76Metabolic pathways_Homo sapiens_hsa011000.55617390
77Hedgehog signaling pathway_Homo sapiens_hsa043400.55454805
78Pyruvate metabolism_Homo sapiens_hsa006200.51843326
79Pyrimidine metabolism_Homo sapiens_hsa002400.50752096
80Insulin secretion_Homo sapiens_hsa049110.47766977
81Gap junction_Homo sapiens_hsa045400.44502981
82Biosynthesis of amino acids_Homo sapiens_hsa012300.44373430
83Fatty acid metabolism_Homo sapiens_hsa012120.42924749
84Arginine and proline metabolism_Homo sapiens_hsa003300.39026425
85Hippo signaling pathway_Homo sapiens_hsa043900.38702661
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38539234
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32311479
88Carbon metabolism_Homo sapiens_hsa012000.31435562
89Cell cycle_Homo sapiens_hsa041100.30656113
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27321539
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27018938
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26634284
93cAMP signaling pathway_Homo sapiens_hsa040240.26206146
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25565904
95Linoleic acid metabolism_Homo sapiens_hsa005910.25075764
96Long-term potentiation_Homo sapiens_hsa047200.24946644
97Ras signaling pathway_Homo sapiens_hsa040140.23316144
98Phenylalanine metabolism_Homo sapiens_hsa003600.20666620
99Wnt signaling pathway_Homo sapiens_hsa043100.20356394
100Homologous recombination_Homo sapiens_hsa034400.17362420

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